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49	deal	_	_	_	_	_	_	_	_
50	with	_	_	_	_	_	_	_	_
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77	developing	_	_	_	_	_	_	_	_
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161	systems	_	_	_	_	_	_	_	_
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76	(	_	_	_	_	_	_	_	_
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78	)	_	_	_	_	_	_	_	_
79	implemented	_	_	_	_	_	_	_	_
80	travel	_	_	_	_	_	_	_	_
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83	that	_	_	_	_	_	_	_	_
84	non	_	_	_	_	_	_	_	_
85	-	_	_	_	_	_	_	_	_
86	residents	_	_	_	_	_	_	_	_
87	were	_	_	_	_	_	_	_	_
88	required	_	_	_	_	_	_	_	_
89	to	_	_	_	_	_	_	_	_
90	have	_	_	_	_	_	_	_	_
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95	province	_	_	_	_	_	_	_	_
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101	a	_	_	_	_	_	_	_	_
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106	data	_	_	_	_	_	_	_	_
107	describing	_	_	_	_	_	_	_	BeginSeg=Yes
108	the	_	_	_	_	_	_	_	_
109	number	_	_	_	_	_	_	_	_
110	of	_	_	_	_	_	_	_	_
111	active	_	_	_	_	_	_	_	_
112	COVID-19	_	_	_	_	_	_	_	_
113	cases	_	_	_	_	_	_	_	_
114	in	_	_	_	_	_	_	_	_
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117	March	_	_	_	_	_	_	_	_
118	14	_	_	_	_	_	_	_	_
119	th	_	_	_	_	_	_	_	_
120	-May	_	_	_	_	_	_	_	_
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125	then	_	_	_	_	_	_	_	_
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135	May	_	_	_	_	_	_	_	_
136	4	_	_	_	_	_	_	_	_
137	th	_	_	_	_	_	_	_	_
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157	70	_	_	_	_	_	_	_	_
158	%	_	_	_	_	_	_	_	_
159	reduction	_	_	_	_	_	_	_	_
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162	daily	_	_	_	_	_	_	_	_
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167	pre	_	_	_	_	_	_	_	_
168	-	_	_	_	_	_	_	_	_
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170	levels	_	_	_	_	_	_	_	_
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173	:	_	_	_	_	_	_	_	_
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186	been	_	_	_	_	_	_	_	_
187	12.4	_	_	_	_	_	_	_	_
188	times	_	_	_	_	_	_	_	_
189	higher	_	_	_	_	_	_	_	_
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218	show	_	_	_	_	_	_	_	_
219	how	_	_	_	_	_	_	_	BeginSeg=Yes
220	the	_	_	_	_	_	_	_	_
221	NL	_	_	_	_	_	_	_	_
222	COVID-19	_	_	_	_	_	_	_	_
223	outbreak	_	_	_	_	_	_	_	_
224	could	_	_	_	_	_	_	_	_
225	have	_	_	_	_	_	_	_	_
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227	had	_	_	_	_	_	_	_	_
228	the	_	_	_	_	_	_	_	_
229	travel	_	_	_	_	_	_	_	_
230	restrictions	_	_	_	_	_	_	_	_
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232	been	_	_	_	_	_	_	_	_
233	implemented	_	_	_	_	_	_	_	_
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242	the	_	_	_	_	_	_	_	_
243	local	_	_	_	_	_	_	_	_
244	dynamics	_	_	_	_	_	_	_	_
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246	the	_	_	_	_	_	_	_	_
247	epidemic	_	_	_	_	_	_	_	_
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257	a	_	_	_	_	_	_	_	_
258	plausible	_	_	_	_	_	_	_	_
259	reason	_	_	_	_	_	_	_	_
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261	there	_	_	_	_	_	_	_	_
262	were	_	_	_	_	_	_	_	_
263	so	_	_	_	_	_	_	_	_
264	few	_	_	_	_	_	_	_	_
265	reported	_	_	_	_	_	_	_	_
266	COVID-19	_	_	_	_	_	_	_	_
267	cases	_	_	_	_	_	_	_	_
268	in	_	_	_	_	_	_	_	_
269	NL	_	_	_	_	_	_	_	_
270	in	_	_	_	_	_	_	_	_
271	the	_	_	_	_	_	_	_	_
272	9	_	_	_	_	_	_	_	_
273	weeks	_	_	_	_	_	_	_	_
274	after	_	_	_	_	_	_	_	_
275	May	_	_	_	_	_	_	_	_
276	4	_	_	_	_	_	_	_	_
277	th	_	_	_	_	_	_	_	_
278	.	_	_	_	_	_	_	_	_

# newdoc_id = 04863be13c7778ac3779da61eba8b49a510d9f40
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7	contribute	_	_	_	_	_	_	_	_
8	to	_	_	_	_	_	_	_	_
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10	control	_	_	_	_	_	_	_	_
11	of	_	_	_	_	_	_	_	_
12	COVID-19	_	_	_	_	_	_	_	_
13	outbreaks	_	_	_	_	_	_	_	_
14	.	_	_	_	_	_	_	_	_
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16	,	_	_	_	_	_	_	_	_
17	it	_	_	_	_	_	_	_	_
18	remains	_	_	_	_	_	_	_	_
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30	efficiency	_	_	_	_	_	_	_	_
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36	address	_	_	_	_	_	_	_	_
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38	issue	_	_	_	_	_	_	_	_
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42	control	_	_	_	_	_	_	_	_
43	strategies	_	_	_	_	_	_	_	_
44	for	_	_	_	_	_	_	_	_
45	SARS	_	_	_	_	_	_	_	_
46	-	_	_	_	_	_	_	_	_
47	CoV-2	_	_	_	_	_	_	_	_
48	in	_	_	_	_	_	_	_	_
49	a	_	_	_	_	_	_	_	_
50	real	_	_	_	_	_	_	_	_
51	-	_	_	_	_	_	_	_	_
52	world	_	_	_	_	_	_	_	_

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12	Fitbit	_	_	_	_	_	_	_	_
13	,	_	_	_	_	_	_	_	_
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34	little	_	_	_	_	_	_	_	_
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37	about	_	_	_	_	_	_	_	_
38-39	seniors'	_	_	_	_	_	_	_	_
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52	investigates	_	_	_	_	_	_	_	_
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91	decisions	_	_	_	_	_	_	_	_
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114	output	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	wearable	_	_	_	_	_	_	_	_
117	devices	_	_	_	_	_	_	_	_
118	is	_	_	_	_	_	_	_	BeginSeg=Yes
119	the	_	_	_	_	_	_	_	_
120	main	_	_	_	_	_	_	_	_
121	deterring	_	_	_	_	_	_	_	_
122	element	_	_	_	_	_	_	_	_
123	.	_	_	_	_	_	_	_	_
124	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
125	,	_	_	_	_	_	_	_	_
126	we	_	_	_	_	_	_	_	_
127	explored	_	_	_	_	_	_	_	_
128	the	_	_	_	_	_	_	_	_
129	role	_	_	_	_	_	_	_	_
130	of	_	_	_	_	_	_	_	_
131	two	_	_	_	_	_	_	_	_
132	important	_	_	_	_	_	_	_	_
133	elements	_	_	_	_	_	_	_	_
134	:	_	_	_	_	_	_	_	_
135-136	seniors'	_	_	_	_	_	_	_	_
135	seniors	_	_	_	_	_	_	_	BeginSeg=Yes
136	'	_	_	_	_	_	_	_	_
137	cognitive	_	_	_	_	_	_	_	_
138	age	_	_	_	_	_	_	_	_
139	,	_	_	_	_	_	_	_	_
140	and	_	_	_	_	_	_	_	_
141	the	_	_	_	_	_	_	_	_
142	influence	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	their	_	_	_	_	_	_	_	_
145	subjective	_	_	_	_	_	_	_	_
146	well	_	_	_	_	_	_	_	_
147	-	_	_	_	_	_	_	_	_
148	being	_	_	_	_	_	_	_	_
149	on	_	_	_	_	_	_	_	_
150	their	_	_	_	_	_	_	_	_
151	adoption	_	_	_	_	_	_	_	_
152	behavior	_	_	_	_	_	_	_	_
153	.	_	_	_	_	_	_	_	_
154	Results	_	_	_	_	_	_	_	BeginSeg=Yes
155	demonstrated	_	_	_	_	_	_	_	_
156	that	_	_	_	_	_	_	_	BeginSeg=Yes
157	cognitive	_	_	_	_	_	_	_	_
158	age	_	_	_	_	_	_	_	_
159	does	_	_	_	_	_	_	_	_
160	not	_	_	_	_	_	_	_	_
161	significantly	_	_	_	_	_	_	_	_
162	impact	_	_	_	_	_	_	_	_
163	use	_	_	_	_	_	_	_	_
164	intention	_	_	_	_	_	_	_	_
165	by	_	_	_	_	_	_	_	_
166	itself	_	_	_	_	_	_	_	_
167	;	_	_	_	_	_	_	_	_
168	nonetheless	_	_	_	_	_	_	_	BeginSeg=Yes
169	,	_	_	_	_	_	_	_	_
170	subjective	_	_	_	_	_	_	_	_
171	wellbeing	_	_	_	_	_	_	_	_
172	moderates	_	_	_	_	_	_	_	_
173	its	_	_	_	_	_	_	_	_
174	effect	_	_	_	_	_	_	_	_
175	.	_	_	_	_	_	_	_	_
176	This	_	_	_	_	_	_	_	BeginSeg=Yes
177	result	_	_	_	_	_	_	_	_
178	revealed	_	_	_	_	_	_	_	_
179	an	_	_	_	_	_	_	_	_
180	interesting	_	_	_	_	_	_	_	_
181	finding	_	_	_	_	_	_	_	_
182	,	_	_	_	_	_	_	_	_
183	which	_	_	_	_	_	_	_	BeginSeg=Yes
184	is	_	_	_	_	_	_	_	_
185	that	_	_	_	_	_	_	_	_
186	the	_	_	_	_	_	_	_	_
187	influence	_	_	_	_	_	_	_	_
188	of	_	_	_	_	_	_	_	_
189	cognitive	_	_	_	_	_	_	_	_
190	age	_	_	_	_	_	_	_	_
191	on	_	_	_	_	_	_	_	_
192-193	seniors'	_	_	_	_	_	_	_	_
192	seniors	_	_	_	_	_	_	_	_
193	'	_	_	_	_	_	_	_	_
194	use	_	_	_	_	_	_	_	_
195	intention	_	_	_	_	_	_	_	_
196	depends	_	_	_	_	_	_	_	_
197	on	_	_	_	_	_	_	_	_
198-199	seniors'	_	_	_	_	_	_	_	_
198	seniors	_	_	_	_	_	_	_	_
199	'	_	_	_	_	_	_	_	_
200	level	_	_	_	_	_	_	_	_
201	of	_	_	_	_	_	_	_	_
202	subjective	_	_	_	_	_	_	_	_
203	well	_	_	_	_	_	_	_	_
204	-	_	_	_	_	_	_	_	_
205	being	_	_	_	_	_	_	_	_
206	.	_	_	_	_	_	_	_	_
207	When	_	_	_	_	_	_	_	BeginSeg=Yes
208-209	seniors'	_	_	_	_	_	_	_	_
208	seniors	_	_	_	_	_	_	_	_
209	'	_	_	_	_	_	_	_	_
210	subjective	_	_	_	_	_	_	_	_
211	well	_	_	_	_	_	_	_	_
212	-	_	_	_	_	_	_	_	_
213	being	_	_	_	_	_	_	_	_
214	is	_	_	_	_	_	_	_	_
215	low	_	_	_	_	_	_	_	_
216	,	_	_	_	_	_	_	_	_
217	surprisingly	_	_	_	_	_	_	_	BeginSeg=Yes
218	,	_	_	_	_	_	_	_	_
219	cognitive	_	_	_	_	_	_	_	_
220	age	_	_	_	_	_	_	_	_
221	increases	_	_	_	_	_	_	_	_
222-223	seniors'	_	_	_	_	_	_	_	_
222	seniors	_	_	_	_	_	_	_	_
223	'	_	_	_	_	_	_	_	_
224	intention	_	_	_	_	_	_	_	_
225	to	_	_	_	_	_	_	_	BeginSeg=Yes
226	use	_	_	_	_	_	_	_	_
227	the	_	_	_	_	_	_	_	_
228	device	_	_	_	_	_	_	_	_
229	.	_	_	_	_	_	_	_	_
230	These	_	_	_	_	_	_	_	BeginSeg=Yes
231	findings	_	_	_	_	_	_	_	_
232	provide	_	_	_	_	_	_	_	_
233	interesting	_	_	_	_	_	_	_	_
234	implications	_	_	_	_	_	_	_	_
235	for	_	_	_	_	_	_	_	_
236	practice	_	_	_	_	_	_	_	_
237	and	_	_	_	_	_	_	_	_
238	future	_	_	_	_	_	_	_	_
239	research	_	_	_	_	_	_	_	_
240	.	_	_	_	_	_	_	_	_

# newdoc_id = 066178ded1d6d540be366e6468bc01e78e605a81
1	Genotyping	_	_	_	_	_	_	_	BeginSeg=Yes
2	of	_	_	_	_	_	_	_	_
3	avian	_	_	_	_	_	_	_	_
4	infectious	_	_	_	_	_	_	_	_
5	bronchitis	_	_	_	_	_	_	_	_
6	virus	_	_	_	_	_	_	_	_
7	(	_	_	_	_	_	_	_	_
8	IBV	_	_	_	_	_	_	_	_
9	)	_	_	_	_	_	_	_	_
10	was	_	_	_	_	_	_	_	_
11	performed	_	_	_	_	_	_	_	_
12	on	_	_	_	_	_	_	_	_
13	trachea	_	_	_	_	_	_	_	_
14	and	_	_	_	_	_	_	_	_
15	kidney	_	_	_	_	_	_	_	_
16	samples	_	_	_	_	_	_	_	_
17	of	_	_	_	_	_	_	_	_
18	six	_	_	_	_	_	_	_	_
19	chickens	_	_	_	_	_	_	_	_
20	obtained	_	_	_	_	_	_	_	BeginSeg=Yes
21	from	_	_	_	_	_	_	_	_
22	a	_	_	_	_	_	_	_	_
23	single	_	_	_	_	_	_	_	_
24	farm	_	_	_	_	_	_	_	_
25	in	_	_	_	_	_	_	_	_
26	Japan	_	_	_	_	_	_	_	_
27	.	_	_	_	_	_	_	_	_
28	Using	_	_	_	_	_	_	_	BeginSeg=Yes
29	two	_	_	_	_	_	_	_	_
30	primer	_	_	_	_	_	_	_	_
31	sets	_	_	_	_	_	_	_	_
32	targeting	_	_	_	_	_	_	_	BeginSeg=Yes
33	the	_	_	_	_	_	_	_	_
34	spike	_	_	_	_	_	_	_	_
35	(	_	_	_	_	_	_	_	_
36	S	_	_	_	_	_	_	_	_
37	)	_	_	_	_	_	_	_	_
38	protein	_	_	_	_	_	_	_	_
39	gene	_	_	_	_	_	_	_	_
40	,	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	BeginSeg=Yes
42	S1	_	_	_	_	_	_	_	_
43	and	_	_	_	_	_	_	_	_
44	S2	_	_	_	_	_	_	_	_
45	regions	_	_	_	_	_	_	_	_
46	of	_	_	_	_	_	_	_	_
47	DNA	_	_	_	_	_	_	_	_
48	fragments	_	_	_	_	_	_	_	_
49	were	_	_	_	_	_	_	_	_
50	amplified	_	_	_	_	_	_	_	_
51	.	_	_	_	_	_	_	_	_
52	Sequences	_	_	_	_	_	_	_	BeginSeg=Yes
53	of	_	_	_	_	_	_	_	_
54	amplified	_	_	_	_	_	_	_	_
55	S1	_	_	_	_	_	_	_	_
56	fragments	_	_	_	_	_	_	_	_
57	extracted	_	_	_	_	_	_	_	BeginSeg=Yes
58	from	_	_	_	_	_	_	_	_
59	both	_	_	_	_	_	_	_	_
60	organs	_	_	_	_	_	_	_	_
61	were	_	_	_	_	_	_	_	BeginSeg=Yes
62	identical	_	_	_	_	_	_	_	_
63	among	_	_	_	_	_	_	_	_
64	the	_	_	_	_	_	_	_	_
65	six	_	_	_	_	_	_	_	_
66	chickens	_	_	_	_	_	_	_	_
67	,	_	_	_	_	_	_	_	_
68	showing	_	_	_	_	_	_	_	BeginSeg=Yes
69	a	_	_	_	_	_	_	_	_
70	JP	_	_	_	_	_	_	_	_
71	-	_	_	_	_	_	_	_	_
72	I	_	_	_	_	_	_	_	_
73	genotype	_	_	_	_	_	_	_	_
74	.	_	_	_	_	_	_	_	_
75	Sequences	_	_	_	_	_	_	_	BeginSeg=Yes
76	of	_	_	_	_	_	_	_	_
77	amplified	_	_	_	_	_	_	_	_
78	S2	_	_	_	_	_	_	_	_
79	fragments	_	_	_	_	_	_	_	_
80	differed	_	_	_	_	_	_	_	_
81	between	_	_	_	_	_	_	_	_
82	trachea	_	_	_	_	_	_	_	_
83	and	_	_	_	_	_	_	_	_
84	kidney	_	_	_	_	_	_	_	_
85	samples	_	_	_	_	_	_	_	_
86	.	_	_	_	_	_	_	_	_
87	The	_	_	_	_	_	_	_	BeginSeg=Yes
88	kidney	_	_	_	_	_	_	_	_
89	profile	_	_	_	_	_	_	_	_
90	showed	_	_	_	_	_	_	_	_
91	a	_	_	_	_	_	_	_	_
92	group	_	_	_	_	_	_	_	_
93	IV	_	_	_	_	_	_	_	_
94	genotype	_	_	_	_	_	_	_	_
95	,	_	_	_	_	_	_	_	_
96	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
97	the	_	_	_	_	_	_	_	_
98	trachea	_	_	_	_	_	_	_	_
99	profile	_	_	_	_	_	_	_	_
100	showed	_	_	_	_	_	_	_	_
101	an	_	_	_	_	_	_	_	_
102	unclassified	_	_	_	_	_	_	_	_
103	group	_	_	_	_	_	_	_	_
104	.	_	_	_	_	_	_	_	_
105	This	_	_	_	_	_	_	_	BeginSeg=Yes
106	result	_	_	_	_	_	_	_	_
107	showed	_	_	_	_	_	_	_	_
108	that	_	_	_	_	_	_	_	BeginSeg=Yes
109	two	_	_	_	_	_	_	_	_
110	different	_	_	_	_	_	_	_	_
111	IBVs	_	_	_	_	_	_	_	_
112	infected	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	six	_	_	_	_	_	_	_	_
115	chickens	_	_	_	_	_	_	_	_
116	.	_	_	_	_	_	_	_	_
117	The	_	_	_	_	_	_	_	BeginSeg=Yes
118	first	_	_	_	_	_	_	_	_
119	IBV	_	_	_	_	_	_	_	_
120	infection	_	_	_	_	_	_	_	_
121	induced	_	_	_	_	_	_	_	_
122	poor	_	_	_	_	_	_	_	_
123	protective	_	_	_	_	_	_	_	_
124	immunity	_	_	_	_	_	_	_	_
125	in	_	_	_	_	_	_	_	_
126	this	_	_	_	_	_	_	_	_
127	farm	_	_	_	_	_	_	_	_
128	,	_	_	_	_	_	_	_	_
129	permitting	_	_	_	_	_	_	_	BeginSeg=Yes
130	a	_	_	_	_	_	_	_	_
131	second	_	_	_	_	_	_	_	_
132	IBV	_	_	_	_	_	_	_	_
133	infection	_	_	_	_	_	_	_	_
134	to	_	_	_	_	_	_	_	_
135	occur	_	_	_	_	_	_	_	_
136	.	_	_	_	_	_	_	_	_

# newdoc_id = 08792e906a1020ea71007183b91e581d378a9261
1	In	_	_	_	_	_	_	_	BeginSeg=Yes
2	the	_	_	_	_	_	_	_	_
3	time	_	_	_	_	_	_	_	_
4	of	_	_	_	_	_	_	_	_
5	COVID-19	_	_	_	_	_	_	_	_
6	epidemic	_	_	_	_	_	_	_	_
7	,	_	_	_	_	_	_	_	_
8	Italy	_	_	_	_	_	_	_	_
9	was	_	_	_	_	_	_	_	_
10	found	_	_	_	_	_	_	_	_
11	unprepared	_	_	_	_	_	_	_	_
12	to	_	_	_	_	_	_	_	_
13	manage	_	_	_	_	_	_	_	_
14	lockdown	_	_	_	_	_	_	_	_
15	patients	_	_	_	_	_	_	_	_
16	with	_	_	_	_	_	_	_	_
17	chronic	_	_	_	_	_	_	_	_
18	diseases	_	_	_	_	_	_	_	_
19	,	_	_	_	_	_	_	_	_
20	due	_	_	_	_	_	_	_	BeginSeg=Yes
21	to	_	_	_	_	_	_	_	_
22	limited	_	_	_	_	_	_	_	_
23	availability	_	_	_	_	_	_	_	_
24	and	_	_	_	_	_	_	_	_
25	diffusion	_	_	_	_	_	_	_	_
26	of	_	_	_	_	_	_	_	_
27	large	_	_	_	_	_	_	_	_
28	-	_	_	_	_	_	_	_	_
29	scale	_	_	_	_	_	_	_	_
30	telemedicine	_	_	_	_	_	_	_	_
31	solutions	_	_	_	_	_	_	_	_
32	.	_	_	_	_	_	_	_	_
33	The	_	_	_	_	_	_	_	BeginSeg=Yes
34	scattered	_	_	_	_	_	_	_	_
35	distribution	_	_	_	_	_	_	_	_
36	and	_	_	_	_	_	_	_	_
37	heterogeneity	_	_	_	_	_	_	_	_
38	of	_	_	_	_	_	_	_	_
39	available	_	_	_	_	_	_	_	_
40	tools	_	_	_	_	_	_	_	_
41	,	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
43	lack	_	_	_	_	_	_	_	_
44	of	_	_	_	_	_	_	_	_
45	integration	_	_	_	_	_	_	_	_
46	with	_	_	_	_	_	_	_	_
47	the	_	_	_	_	_	_	_	_
48	electronic	_	_	_	_	_	_	_	_
49	health	_	_	_	_	_	_	_	_
50	record	_	_	_	_	_	_	_	_
51	of	_	_	_	_	_	_	_	_
52	the	_	_	_	_	_	_	_	_
53	national	_	_	_	_	_	_	_	_
54	health	_	_	_	_	_	_	_	_
55	system	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	the	_	_	_	_	_	_	_	_
58	poor	_	_	_	_	_	_	_	_
59	interconnection	_	_	_	_	_	_	_	_
60	between	_	_	_	_	_	_	_	_
61	telemedicine	_	_	_	_	_	_	_	_
62	services	_	_	_	_	_	_	_	_
63	operating	_	_	_	_	_	_	_	BeginSeg=Yes
64	at	_	_	_	_	_	_	_	_
65	different	_	_	_	_	_	_	_	_
66	levels	_	_	_	_	_	_	_	_
67	,	_	_	_	_	_	_	_	_
68	the	_	_	_	_	_	_	_	BeginSeg=Yes
69	lack	_	_	_	_	_	_	_	_
70	of	_	_	_	_	_	_	_	_
71	a	_	_	_	_	_	_	_	_
72	real	_	_	_	_	_	_	_	_
73	multidisciplinary	_	_	_	_	_	_	_	_
74	approach	_	_	_	_	_	_	_	_
75	to	_	_	_	_	_	_	_	_
76	the	_	_	_	_	_	_	_	_
77-78	patient's	_	_	_	_	_	_	_	_
77	patient	_	_	_	_	_	_	_	_
78	's	_	_	_	_	_	_	_	_
79	management	_	_	_	_	_	_	_	_
80	,	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	heavy	_	_	_	_	_	_	_	_
83	privacy	_	_	_	_	_	_	_	_
84	regulations	_	_	_	_	_	_	_	_
85	,	_	_	_	_	_	_	_	_
86	and	_	_	_	_	_	_	_	_
87	lack	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
89	clear	_	_	_	_	_	_	_	_
90	guidelines	_	_	_	_	_	_	_	_
91	,	_	_	_	_	_	_	_	_
92	together	_	_	_	_	_	_	_	_
93	with	_	_	_	_	_	_	_	_
94	the	_	_	_	_	_	_	_	_
95	lack	_	_	_	_	_	_	_	_
96	of	_	_	_	_	_	_	_	_
97	reimbursement	_	_	_	_	_	_	_	_
98	,	_	_	_	_	_	_	_	_
99	all	_	_	_	_	_	_	_	_
100	hinder	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	implementation	_	_	_	_	_	_	_	_
103	of	_	_	_	_	_	_	_	_
104	effective	_	_	_	_	_	_	_	_
105	telemedicine	_	_	_	_	_	_	_	_
106	solutions	_	_	_	_	_	_	_	_
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109	-	_	_	_	_	_	_	_	_
110	term	_	_	_	_	_	_	_	_
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111	patients	_	_	_	_	_	_	_	_
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113	management	_	_	_	_	_	_	_	_
114	.	_	_	_	_	_	_	_	_
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116	COVID-19	_	_	_	_	_	_	_	_
117	epidemic	_	_	_	_	_	_	_	_
118	should	_	_	_	_	_	_	_	_
119	help	_	_	_	_	_	_	_	_
120	promote	_	_	_	_	_	_	_	_
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124	a	_	_	_	_	_	_	_	_
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128	telemedicine	_	_	_	_	_	_	_	_
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130	in	_	_	_	_	_	_	_	_
131	the	_	_	_	_	_	_	_	_
132	armamentarium	_	_	_	_	_	_	_	_
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136	services	_	_	_	_	_	_	_	_
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139	must	_	_	_	_	_	_	_	_
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150	on	_	_	_	_	_	_	_	_
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152	react	_	_	_	_	_	_	_	_
153	to	_	_	_	_	_	_	_	_
154	an	_	_	_	_	_	_	_	_
155	emergency	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_

# newdoc_id = 08cd7c215584f4c46d198988d3b3feb276067552
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7	Syndrome	_	_	_	_	_	_	_	_
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15	Middle	_	_	_	_	_	_	_	_
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72	other	_	_	_	_	_	_	_	_
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96	humans	_	_	_	_	_	_	_	_
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107	in	_	_	_	_	_	_	_	BeginSeg=Yes
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119	compare	_	_	_	_	_	_	_	_
120	the	_	_	_	_	_	_	_	_
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122	animal	_	_	_	_	_	_	_	_
123	models	_	_	_	_	_	_	_	_
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125	have	_	_	_	_	_	_	_	_
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129	study	_	_	_	_	_	_	_	_
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134	MERS	_	_	_	_	_	_	_	_
135	-	_	_	_	_	_	_	_	_
136	CoV.	_	_	_	_	_	_	_	_
137	SARS	_	_	_	_	_	_	_	BeginSeg=Yes
138	-	_	_	_	_	_	_	_	_
139	CoV	_	_	_	_	_	_	_	_
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141	shown	_	_	_	_	_	_	_	_
142	to	_	_	_	_	_	_	_	_
143	infect	_	_	_	_	_	_	_	_
144	rhesus	_	_	_	_	_	_	_	_
145	macaques	_	_	_	_	_	_	_	_
146	[	_	_	_	_	_	_	_	_
147	22	_	_	_	_	_	_	_	_
148	,	_	_	_	_	_	_	_	_
149	23	_	_	_	_	_	_	_	_
150	]	_	_	_	_	_	_	_	_
151	cynomolgus	_	_	_	_	_	_	_	_
152	macaques	_	_	_	_	_	_	_	_
153	[	_	_	_	_	_	_	_	_
154	22	_	_	_	_	_	_	_	_
155	]	_	_	_	_	_	_	_	_
156	[	_	_	_	_	_	_	_	_
157	23	_	_	_	_	_	_	_	_
158	]	_	_	_	_	_	_	_	_
159	[	_	_	_	_	_	_	_	_
160	24	_	_	_	_	_	_	_	_
161	]	_	_	_	_	_	_	_	_
162	[	_	_	_	_	_	_	_	_
163	25	_	_	_	_	_	_	_	_
164	]	_	_	_	_	_	_	_	_
165	[	_	_	_	_	_	_	_	_
166	26	_	_	_	_	_	_	_	_
167	]	_	_	_	_	_	_	_	_
168	and	_	_	_	_	_	_	_	_
169	African	_	_	_	_	_	_	_	_
170	green	_	_	_	_	_	_	_	_
171	monkeys	_	_	_	_	_	_	_	_
172	(	_	_	_	_	_	_	_	_
173	AGMs	_	_	_	_	_	_	_	_
174	)	_	_	_	_	_	_	_	_
175	[	_	_	_	_	_	_	_	_
176	22	_	_	_	_	_	_	_	_
177	]	_	_	_	_	_	_	_	_
178	.	_	_	_	_	_	_	_	_
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180	signs	_	_	_	_	_	_	_	_
181	,	_	_	_	_	_	_	_	_
182	viral	_	_	_	_	_	_	_	_
183	replication	_	_	_	_	_	_	_	_
184	and	_	_	_	_	_	_	_	_
185	pathology	_	_	_	_	_	_	_	_
186	depended	_	_	_	_	_	_	_	_
187	upon	_	_	_	_	_	_	_	_
188	the	_	_	_	_	_	_	_	_
189	species	_	_	_	_	_	_	_	_
190	.	_	_	_	_	_	_	_	_
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192	is	_	_	_	_	_	_	_	_
193	at	_	_	_	_	_	_	_	_
194	least	_	_	_	_	_	_	_	_
195	one	_	_	_	_	_	_	_	_
196	report	_	_	_	_	_	_	_	_
197	of	_	_	_	_	_	_	_	_
198	pneumonitis	_	_	_	_	_	_	_	_
199	in	_	_	_	_	_	_	_	_
200	each	_	_	_	_	_	_	_	_
201	species	_	_	_	_	_	_	_	_
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203	the	_	_	_	_	_	_	_	_
204	findings	_	_	_	_	_	_	_	_
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206	non	_	_	_	_	_	_	_	_
207	-	_	_	_	_	_	_	_	_
208	human	_	_	_	_	_	_	_	_
209	primates	_	_	_	_	_	_	_	_
210	(	_	_	_	_	_	_	_	_
211	NHPs	_	_	_	_	_	_	_	_
212	)	_	_	_	_	_	_	_	_
213	were	_	_	_	_	_	_	_	_
214	variable	_	_	_	_	_	_	_	_
215	,	_	_	_	_	_	_	_	_
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217	because	_	_	_	_	_	_	_	_
218	of	_	_	_	_	_	_	_	_
219	genetic	_	_	_	_	_	_	_	_
220	Gretebeck	_	_	_	_	_	_	_	_
221	and	_	_	_	_	_	_	_	_
222	Subbarao	_	_	_	_	_	_	_	_

# newdoc_id = 0982121b27ae7070996973d0c3d892fe432e8b2a
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2	Surgical	_	_	_	_	_	_	_	BeginSeg=Yes
3	site	_	_	_	_	_	_	_	_
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8	are	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	commonest	_	_	_	_	_	_	_	_
11	healthcare	_	_	_	_	_	_	_	_
12	associated	_	_	_	_	_	_	_	_
13	infections	_	_	_	_	_	_	_	_
14	.	_	_	_	_	_	_	_	_
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16	severely	_	_	_	_	_	_	_	_
17	compromise	_	_	_	_	_	_	_	_
18	patient	_	_	_	_	_	_	_	_
19	safety	_	_	_	_	_	_	_	_
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22	a	_	_	_	_	_	_	_	_
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25	on	_	_	_	_	_	_	_	_
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27	resources	_	_	_	_	_	_	_	_
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37	life	_	_	_	_	_	_	_	_
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40	incidence	_	_	_	_	_	_	_	_
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45	as	_	_	_	_	_	_	_	_
46	high	_	_	_	_	_	_	_	_
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48	10	_	_	_	_	_	_	_	_
49	%	_	_	_	_	_	_	_	_
50	after	_	_	_	_	_	_	_	_
51	colorectal	_	_	_	_	_	_	_	_
52	procedures	_	_	_	_	_	_	_	_
53	.	_	_	_	_	_	_	_	_
54	The	_	_	_	_	_	_	_	BeginSeg=Yes
55	laparoscopic	_	_	_	_	_	_	_	_
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60	used	_	_	_	_	_	_	_	_
61	to	_	_	_	_	_	_	_	BeginSeg=Yes
62	undertake	_	_	_	_	_	_	_	_
63	colorectal	_	_	_	_	_	_	_	_
64	procedures	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
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68	advantages	_	_	_	_	_	_	_	_
69	over	_	_	_	_	_	_	_	_
70	the	_	_	_	_	_	_	_	_
71	traditional	_	_	_	_	_	_	_	_
72	open	_	_	_	_	_	_	_	_
73	approach	_	_	_	_	_	_	_	_
74	with	_	_	_	_	_	_	_	_
75	smaller	_	_	_	_	_	_	_	_
76	incisions	_	_	_	_	_	_	_	_
77	,	_	_	_	_	_	_	_	_
78	shorter	_	_	_	_	_	_	_	_
79	hospital	_	_	_	_	_	_	_	_
80	stay	_	_	_	_	_	_	_	_
81	and	_	_	_	_	_	_	_	_
82	equal	_	_	_	_	_	_	_	_
83	oncological	_	_	_	_	_	_	_	_
84	outcomes	_	_	_	_	_	_	_	_
85	.	_	_	_	_	_	_	_	_
86	The	_	_	_	_	_	_	_	BeginSeg=Yes
87	aim	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
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90	meta	_	_	_	_	_	_	_	_
91	-	_	_	_	_	_	_	_	_
92	analysis	_	_	_	_	_	_	_	_
93	was	_	_	_	_	_	_	_	_
94	to	_	_	_	_	_	_	_	_
95	evaluate	_	_	_	_	_	_	_	_
96	whether	_	_	_	_	_	_	_	_
97	the	_	_	_	_	_	_	_	_
98	laparoscopic	_	_	_	_	_	_	_	_
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100	for	_	_	_	_	_	_	_	_
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119	RCTs	_	_	_	_	_	_	_	_
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186	pathologies	_	_	_	_	_	_	_	_
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191	rectal	_	_	_	_	_	_	_	_
192	cancer	_	_	_	_	_	_	_	_
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194	inflammatory	_	_	_	_	_	_	_	_
195	bowel	_	_	_	_	_	_	_	_
196	disease	_	_	_	_	_	_	_	_
197	and	_	_	_	_	_	_	_	_
198	familial	_	_	_	_	_	_	_	_
199	adenomatous	_	_	_	_	_	_	_	_
200	polyposis	_	_	_	_	_	_	_	_
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262	surgery	_	_	_	_	_	_	_	_
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272	-	_	_	_	_	_	_	_	_
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275	p	_	_	_	_	_	_	_	_
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278	)	_	_	_	_	_	_	_	_
279	.	_	_	_	_	_	_	_	_
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283	surgery	_	_	_	_	_	_	_	_
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285	lowers	_	_	_	_	_	_	_	_
286	the	_	_	_	_	_	_	_	_
287	incidence	_	_	_	_	_	_	_	_
288	of	_	_	_	_	_	_	_	_
289	SSI	_	_	_	_	_	_	_	_
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291	to	_	_	_	_	_	_	_	_
292	open	_	_	_	_	_	_	_	_
293	surgery	_	_	_	_	_	_	_	_
294	.	_	_	_	_	_	_	_	_

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3	paper	_	_	_	_	_	_	_	_
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5	authors	_	_	_	_	_	_	_	_
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11	a	_	_	_	_	_	_	_	_
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90	also	_	_	_	_	_	_	_	_
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95	that	_	_	_	_	_	_	_	_
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98	to	_	_	_	_	_	_	_	_
99	a	_	_	_	_	_	_	_	_
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110	of	_	_	_	_	_	_	_	_
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74	2020	_	_	_	_	_	_	_	_
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86	to	_	_	_	_	_	_	_	_
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90	,	_	_	_	_	_	_	_	_
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98	coagulation	_	_	_	_	_	_	_	_
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118	man	_	_	_	_	_	_	_	_
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123	by	_	_	_	_	_	_	_	_
124	bilateral	_	_	_	_	_	_	_	_
125	pulmonary	_	_	_	_	_	_	_	_
126	embolism	_	_	_	_	_	_	_	_
127	LEARNING	_	_	_	_	_	_	_	BeginSeg=Yes
128	POINTS	_	_	_	_	_	_	_	_
129	•SARS	_	_	_	_	_	_	_	BeginSeg=Yes
130	-	_	_	_	_	_	_	_	_
131	CoV-2	_	_	_	_	_	_	_	_
132	is	_	_	_	_	_	_	_	_
133	a	_	_	_	_	_	_	_	_
134	novel	_	_	_	_	_	_	_	_
135	infectious	_	_	_	_	_	_	_	_
136	agent	_	_	_	_	_	_	_	_
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138	causes	_	_	_	_	_	_	_	_
139	COVID-19	_	_	_	_	_	_	_	_
140	,	_	_	_	_	_	_	_	_
141	which	_	_	_	_	_	_	_	BeginSeg=Yes
142	can	_	_	_	_	_	_	_	_
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144	in	_	_	_	_	_	_	_	_
145	several	_	_	_	_	_	_	_	_
146	ways	_	_	_	_	_	_	_	_
147	,	_	_	_	_	_	_	_	_
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149	endothelial	_	_	_	_	_	_	_	_
150	cells	_	_	_	_	_	_	_	_
151	and	_	_	_	_	_	_	_	_
152	most	_	_	_	_	_	_	_	_
153	organs	_	_	_	_	_	_	_	_
154	.	_	_	_	_	_	_	_	_
155	•There	_	_	_	_	_	_	_	BeginSeg=Yes
156	is	_	_	_	_	_	_	_	_
157	growing	_	_	_	_	_	_	_	_
158	evidenc	_	_	_	_	_	_	_	_
159	that	_	_	_	_	_	_	_	BeginSeg=Yes
160	SARS	_	_	_	_	_	_	_	_
161	-	_	_	_	_	_	_	_	_
162	CoV-2-mediated	_	_	_	_	_	_	_	_
163	endothelial	_	_	_	_	_	_	_	_
164	damage	_	_	_	_	_	_	_	_
165	is	_	_	_	_	_	_	_	_
166	due	_	_	_	_	_	_	_	_
167	to	_	_	_	_	_	_	_	_
168	direct	_	_	_	_	_	_	_	_
169	viral	_	_	_	_	_	_	_	_
170	injury	_	_	_	_	_	_	_	_
171	and	_	_	_	_	_	_	_	_
172	the	_	_	_	_	_	_	_	_
173	systemic	_	_	_	_	_	_	_	_
174	inflammatory	_	_	_	_	_	_	_	_
175	response	_	_	_	_	_	_	_	_
176	,	_	_	_	_	_	_	_	_
177	possibly	_	_	_	_	_	_	_	_
178	together	_	_	_	_	_	_	_	_
179	with	_	_	_	_	_	_	_	_
180	a	_	_	_	_	_	_	_	_
181	cytokine	_	_	_	_	_	_	_	_
182	storm	_	_	_	_	_	_	_	_
183	.	_	_	_	_	_	_	_	_
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185	endothelial	_	_	_	_	_	_	_	_
186	damage	_	_	_	_	_	_	_	_
187	can	_	_	_	_	_	_	_	_
188	manifest	_	_	_	_	_	_	_	_
189	as	_	_	_	_	_	_	_	_
190	thromboembolic	_	_	_	_	_	_	_	_
191	disease	_	_	_	_	_	_	_	_
192	,	_	_	_	_	_	_	_	_
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194	as	_	_	_	_	_	_	_	_
195	pulmonary	_	_	_	_	_	_	_	_
196	thromboembolism	_	_	_	_	_	_	_	_
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199	anti	_	_	_	_	_	_	_	_
200	-	_	_	_	_	_	_	_	_
201	thrombotic	_	_	_	_	_	_	_	_
202	preventive	_	_	_	_	_	_	_	_
203	strategies	_	_	_	_	_	_	_	_
204	should	_	_	_	_	_	_	_	_
205	be	_	_	_	_	_	_	_	_
206	followed	_	_	_	_	_	_	_	_
207	,	_	_	_	_	_	_	_	_
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209	proper	_	_	_	_	_	_	_	_
210	screening	_	_	_	_	_	_	_	_
211	and	_	_	_	_	_	_	_	_
212	treatment	_	_	_	_	_	_	_	_
213	for	_	_	_	_	_	_	_	_
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215	complications	_	_	_	_	_	_	_	_
216	should	_	_	_	_	_	_	_	_
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218	implemented	_	_	_	_	_	_	_	_
219	.	_	_	_	_	_	_	_	_

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90	+	_	_	_	_	_	_	_	_
91	874	_	_	_	_	_	_	_	_
92	ANT	_	_	_	_	_	_	_	_
93	genetic	_	_	_	_	_	_	_	_
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110	higher	_	_	_	_	_	_	_	_
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275	in	_	_	_	_	_	_	_	_
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277	subjects	_	_	_	_	_	_	_	_
278	.	_	_	_	_	_	_	_	_

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62	the	_	_	_	_	_	_	_	_
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28	fibrinolysis	_	_	_	_	_	_	_	_
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30	and	_	_	_	_	_	_	_	_
31	immunity	_	_	_	_	_	_	_	_
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34	recent	_	_	_	_	_	_	_	_
35	years	_	_	_	_	_	_	_	_
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37	a	_	_	_	_	_	_	_	_
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39	of	_	_	_	_	_	_	_	_
40	these	_	_	_	_	_	_	_	_
41	enzymes	_	_	_	_	_	_	_	_
42	has	_	_	_	_	_	_	_	_
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50	plasma	_	_	_	_	_	_	_	_
51	membranes	_	_	_	_	_	_	_	_
52	,	_	_	_	_	_	_	_	_
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69	terminal	_	_	_	_	_	_	_	_
70	transmembrane	_	_	_	_	_	_	_	_
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114	to	_	_	_	_	_	_	_	_
115	processes	_	_	_	_	_	_	_	_
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142	their	_	_	_	_	_	_	_	_
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144	substrates	_	_	_	_	_	_	_	_
145	,	_	_	_	_	_	_	_	_
146	and	_	_	_	_	_	_	_	_
147	their	_	_	_	_	_	_	_	_
148	contributions	_	_	_	_	_	_	_	_
149	to	_	_	_	_	_	_	_	_
150	disease	_	_	_	_	_	_	_	_
151	.	_	_	_	_	_	_	_	_

# newdoc_id = 0a789bc7f1713d549288d3effb72ff34cd3b0ab0
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2	:	_	_	_	_	_	_	_	_
3	Host	_	_	_	_	_	_	_	BeginSeg=Yes
4	proteases	_	_	_	_	_	_	_	_
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6	been	_	_	_	_	_	_	_	_
7	shown	_	_	_	_	_	_	_	_
8	to	_	_	_	_	_	_	_	_
9	play	_	_	_	_	_	_	_	_
10	important	_	_	_	_	_	_	_	_
11	roles	_	_	_	_	_	_	_	_
12	in	_	_	_	_	_	_	_	_
13	many	_	_	_	_	_	_	_	_
14	viral	_	_	_	_	_	_	_	_
15	activities	_	_	_	_	_	_	_	_
16	such	_	_	_	_	_	_	_	BeginSeg=Yes
17	as	_	_	_	_	_	_	_	_
18	entry	_	_	_	_	_	_	_	_
19	,	_	_	_	_	_	_	_	_
20	uncoating	_	_	_	_	_	_	_	_
21	,	_	_	_	_	_	_	_	_
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24	production	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
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27	induction	_	_	_	_	_	_	_	_
28	.	_	_	_	_	_	_	_	_
29	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
30	,	_	_	_	_	_	_	_	_
31	these	_	_	_	_	_	_	_	_
32	cellular	_	_	_	_	_	_	_	_
33	proteases	_	_	_	_	_	_	_	_
34	are	_	_	_	_	_	_	_	_
35	putative	_	_	_	_	_	_	_	_
36	targets	_	_	_	_	_	_	_	_
37	for	_	_	_	_	_	_	_	_
38	the	_	_	_	_	_	_	_	_
39	development	_	_	_	_	_	_	_	_
40	of	_	_	_	_	_	_	_	_
41	antivirals	_	_	_	_	_	_	_	_
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43	inhibit	_	_	_	_	_	_	_	_
44	their	_	_	_	_	_	_	_	_
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48	proteases	_	_	_	_	_	_	_	_
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50	been	_	_	_	_	_	_	_	_
51	described	_	_	_	_	_	_	_	_
52	to	_	_	_	_	_	_	_	_
53	play	_	_	_	_	_	_	_	_
54	essential	_	_	_	_	_	_	_	_
55	roles	_	_	_	_	_	_	_	_
56	in	_	_	_	_	_	_	_	_
57	Ebola	_	_	_	_	_	_	_	_
58	,	_	_	_	_	_	_	_	_
59	HCV	_	_	_	_	_	_	_	_
60	,	_	_	_	_	_	_	_	_
61	HIV	_	_	_	_	_	_	_	_
62	and	_	_	_	_	_	_	_	_
63	influenza	_	_	_	_	_	_	_	_
64	,	_	_	_	_	_	_	_	_
65	such	_	_	_	_	_	_	_	BeginSeg=Yes
66	that	_	_	_	_	_	_	_	_
67	specific	_	_	_	_	_	_	_	_
68	protease	_	_	_	_	_	_	_	_
69	inhibitors	_	_	_	_	_	_	_	_
70	are	_	_	_	_	_	_	_	_
71	able	_	_	_	_	_	_	_	_
72	to	_	_	_	_	_	_	_	_
73	reduce	_	_	_	_	_	_	_	_
74	infection	_	_	_	_	_	_	_	_
75	.	_	_	_	_	_	_	_	_
76	RSV	_	_	_	_	_	_	_	BeginSeg=Yes
77	utilizes	_	_	_	_	_	_	_	_
78	a	_	_	_	_	_	_	_	_
79	host	_	_	_	_	_	_	_	_
80	protease	_	_	_	_	_	_	_	_
81	in	_	_	_	_	_	_	_	_
82	its	_	_	_	_	_	_	_	_
83	replication	_	_	_	_	_	_	_	_
84	cycle	_	_	_	_	_	_	_	_
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86	its	_	_	_	_	_	_	_	_
87	potential	_	_	_	_	_	_	_	_
88	as	_	_	_	_	_	_	_	_
89	antiviral	_	_	_	_	_	_	_	_
90	target	_	_	_	_	_	_	_	_
91	is	_	_	_	_	_	_	_	_
92	unknown	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_
94	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
95	,	_	_	_	_	_	_	_	_
96	we	_	_	_	_	_	_	_	_
97	evaluated	_	_	_	_	_	_	_	_
98	the	_	_	_	_	_	_	_	_
99	effect	_	_	_	_	_	_	_	_
100	of	_	_	_	_	_	_	_	_
101	protease	_	_	_	_	_	_	_	_
102	inhibitors	_	_	_	_	_	_	_	_
103	on	_	_	_	_	_	_	_	_
104	RSV	_	_	_	_	_	_	_	_
105	infection	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	To	_	_	_	_	_	_	_	BeginSeg=Yes
108	measure	_	_	_	_	_	_	_	_
109	the	_	_	_	_	_	_	_	_
110	sensitivity	_	_	_	_	_	_	_	_
111	of	_	_	_	_	_	_	_	_
112	RSV	_	_	_	_	_	_	_	_
113	infection	_	_	_	_	_	_	_	_
114	to	_	_	_	_	_	_	_	_
115	protease	_	_	_	_	_	_	_	_
116	inhibitors	_	_	_	_	_	_	_	_
117	,	_	_	_	_	_	_	_	_
118	cells	_	_	_	_	_	_	_	BeginSeg=Yes
119	were	_	_	_	_	_	_	_	_
120	infected	_	_	_	_	_	_	_	_
121	with	_	_	_	_	_	_	_	_
122	RSV	_	_	_	_	_	_	_	_
123	and	_	_	_	_	_	_	_	BeginSeg=Yes
124	incubated	_	_	_	_	_	_	_	_
125	for	_	_	_	_	_	_	_	_
126	18	_	_	_	_	_	_	_	_
127	h	_	_	_	_	_	_	_	_
128	in	_	_	_	_	_	_	_	_
129	the	_	_	_	_	_	_	_	_
130	presence	_	_	_	_	_	_	_	_
131	or	_	_	_	_	_	_	_	_
132	absence	_	_	_	_	_	_	_	_
133	of	_	_	_	_	_	_	_	_
134	the	_	_	_	_	_	_	_	_
135	inhibitors	_	_	_	_	_	_	_	_
136	.	_	_	_	_	_	_	_	_
137	Cells	_	_	_	_	_	_	_	BeginSeg=Yes
138	were	_	_	_	_	_	_	_	_
139	fixed	_	_	_	_	_	_	_	_
140	,	_	_	_	_	_	_	_	_
141	stained	_	_	_	_	_	_	_	_
142	and	_	_	_	_	_	_	_	_
143	studied	_	_	_	_	_	_	_	_
144	using	_	_	_	_	_	_	_	BeginSeg=Yes
145	fluorescence	_	_	_	_	_	_	_	_
146	microscopy	_	_	_	_	_	_	_	_
147	.	_	_	_	_	_	_	_	_
148	Results	_	_	_	_	_	_	_	BeginSeg=Yes
149	:	_	_	_	_	_	_	_	_
150	Several	_	_	_	_	_	_	_	BeginSeg=Yes
151	protease	_	_	_	_	_	_	_	_
152	inhibitors	_	_	_	_	_	_	_	_
153	,	_	_	_	_	_	_	_	_
154	representing	_	_	_	_	_	_	_	BeginSeg=Yes
155	different	_	_	_	_	_	_	_	_
156	classes	_	_	_	_	_	_	_	_
157	of	_	_	_	_	_	_	_	_
158	proteases	_	_	_	_	_	_	_	_
159	(	_	_	_	_	_	_	_	BeginSeg=Yes
160	AEBSF	_	_	_	_	_	_	_	_
161	,	_	_	_	_	_	_	_	_
162	Pepstatin	_	_	_	_	_	_	_	_
163	A	_	_	_	_	_	_	_	_
164	,	_	_	_	_	_	_	_	_
165	E-64	_	_	_	_	_	_	_	_
166	,	_	_	_	_	_	_	_	_
167	TPCK	_	_	_	_	_	_	_	_
168	,	_	_	_	_	_	_	_	_
169	PMSF	_	_	_	_	_	_	_	_
170	and	_	_	_	_	_	_	_	_
171	aprotinin	_	_	_	_	_	_	_	_
172	)	_	_	_	_	_	_	_	_
173	,	_	_	_	_	_	_	_	_
174	were	_	_	_	_	_	_	_	BeginSeg=Yes
175	tested	_	_	_	_	_	_	_	_
176	for	_	_	_	_	_	_	_	_
177	inhibitory	_	_	_	_	_	_	_	_
178	effects	_	_	_	_	_	_	_	_
179	on	_	_	_	_	_	_	_	_
180	an	_	_	_	_	_	_	_	_
181	RSV	_	_	_	_	_	_	_	_
182	A2	_	_	_	_	_	_	_	_
183	infection	_	_	_	_	_	_	_	_
184	of	_	_	_	_	_	_	_	_
185	HEp-2	_	_	_	_	_	_	_	_
186	cells	_	_	_	_	_	_	_	_
187	.	_	_	_	_	_	_	_	_
188	Different	_	_	_	_	_	_	_	BeginSeg=Yes
189	treatment	_	_	_	_	_	_	_	_
190	durations	_	_	_	_	_	_	_	_
191	,	_	_	_	_	_	_	_	_
192	ranging	_	_	_	_	_	_	_	BeginSeg=Yes
193	from	_	_	_	_	_	_	_	_
194	1	_	_	_	_	_	_	_	_
195	h	_	_	_	_	_	_	_	_
196	prior	_	_	_	_	_	_	_	_
197	to	_	_	_	_	_	_	_	_
198	inoculation	_	_	_	_	_	_	_	_
199	and	_	_	_	_	_	_	_	BeginSeg=Yes
200	continuing	_	_	_	_	_	_	_	_
201	for	_	_	_	_	_	_	_	_
202	18	_	_	_	_	_	_	_	_
203	h	_	_	_	_	_	_	_	_
204	during	_	_	_	_	_	_	_	_
205	the	_	_	_	_	_	_	_	_
206	assay	_	_	_	_	_	_	_	_
207	,	_	_	_	_	_	_	_	_
208	were	_	_	_	_	_	_	_	BeginSeg=Yes
209	evaluated	_	_	_	_	_	_	_	_
210	.	_	_	_	_	_	_	_	_
211	Of	_	_	_	_	_	_	_	BeginSeg=Yes
212	all	_	_	_	_	_	_	_	_
213	the	_	_	_	_	_	_	_	_
214	inhibitors	_	_	_	_	_	_	_	_
215	tested	_	_	_	_	_	_	_	BeginSeg=Yes
216	,	_	_	_	_	_	_	_	_
217	AEBSF	_	_	_	_	_	_	_	BeginSeg=Yes
218	and	_	_	_	_	_	_	_	_
219	TPCK	_	_	_	_	_	_	_	_
220	significantly	_	_	_	_	_	_	_	_
221	decreased	_	_	_	_	_	_	_	_
222	RSV	_	_	_	_	_	_	_	_
223	infection	_	_	_	_	_	_	_	_
224	.	_	_	_	_	_	_	_	_
225	To	_	_	_	_	_	_	_	BeginSeg=Yes
226	ascertain	_	_	_	_	_	_	_	_
227	that	_	_	_	_	_	_	_	BeginSeg=Yes
228	the	_	_	_	_	_	_	_	_
229	observed	_	_	_	_	_	_	_	_
230	effect	_	_	_	_	_	_	_	_
231	of	_	_	_	_	_	_	_	_
232	AEBSF	_	_	_	_	_	_	_	_
233	was	_	_	_	_	_	_	_	_
234	not	_	_	_	_	_	_	_	_
235	a	_	_	_	_	_	_	_	_
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237	feature	_	_	_	_	_	_	_	_
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239	to	_	_	_	_	_	_	_	_
240	HEp-2	_	_	_	_	_	_	_	_
241	cells	_	_	_	_	_	_	_	_
242	,	_	_	_	_	_	_	_	_
243	A549	_	_	_	_	_	_	_	BeginSeg=Yes
244	and	_	_	_	_	_	_	_	_
245	BEAS-2B	_	_	_	_	_	_	_	_
246	cells	_	_	_	_	_	_	_	_
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249	used	_	_	_	_	_	_	_	_
250	.	_	_	_	_	_	_	_	_
251	Similar	_	_	_	_	_	_	_	BeginSeg=Yes
252	to	_	_	_	_	_	_	_	_
253	HEp-2	_	_	_	_	_	_	_	_
254	,	_	_	_	_	_	_	_	_
255	an	_	_	_	_	_	_	_	_
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257	complete	_	_	_	_	_	_	_	_
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259	in	_	_	_	_	_	_	_	_
260	the	_	_	_	_	_	_	_	_
261	number	_	_	_	_	_	_	_	_
262	of	_	_	_	_	_	_	_	_
263	RSV	_	_	_	_	_	_	_	_
264	infected	_	_	_	_	_	_	_	_
265	cells	_	_	_	_	_	_	_	_
266	after	_	_	_	_	_	_	_	_
267	18	_	_	_	_	_	_	_	_
268	h	_	_	_	_	_	_	_	_
269	of	_	_	_	_	_	_	_	_
270	incubation	_	_	_	_	_	_	_	_
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272	observed	_	_	_	_	_	_	_	_
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275	effect	_	_	_	_	_	_	_	_
276	was	_	_	_	_	_	_	_	_
277	dose	_	_	_	_	_	_	_	_
278	-	_	_	_	_	_	_	_	_
279	dependent	_	_	_	_	_	_	_	_
280	.	_	_	_	_	_	_	_	_
281	To	_	_	_	_	_	_	_	BeginSeg=Yes
282	gain	_	_	_	_	_	_	_	_
283	insight	_	_	_	_	_	_	_	_
284	into	_	_	_	_	_	_	_	_
285	the	_	_	_	_	_	_	_	_
286	mechanism	_	_	_	_	_	_	_	_
287	of	_	_	_	_	_	_	_	_
288	this	_	_	_	_	_	_	_	_
289	inhibition	_	_	_	_	_	_	_	_
290	,	_	_	_	_	_	_	_	_
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292	treatment	_	_	_	_	_	_	_	_
293	was	_	_	_	_	_	_	_	_
294	applied	_	_	_	_	_	_	_	_
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296	different	_	_	_	_	_	_	_	_
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299	an	_	_	_	_	_	_	_	_
300	infection	_	_	_	_	_	_	_	_
301	cycle	_	_	_	_	_	_	_	_
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303	pre-	_	_	_	_	_	_	_	_
304	,	_	_	_	_	_	_	_	_
305	peri	_	_	_	_	_	_	_	_
306	-	_	_	_	_	_	_	_	_
307	and	_	_	_	_	_	_	_	_
308	post	_	_	_	_	_	_	_	_
309	-	_	_	_	_	_	_	_	_
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311	treatment	_	_	_	_	_	_	_	_
312	)	_	_	_	_	_	_	_	_
313	.	_	_	_	_	_	_	_	_
314	The	_	_	_	_	_	_	_	BeginSeg=Yes
315	results	_	_	_	_	_	_	_	_
316	from	_	_	_	_	_	_	_	_
317	these	_	_	_	_	_	_	_	_
318	experiments	_	_	_	_	_	_	_	_
319	indicate	_	_	_	_	_	_	_	_
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321	AEBSF	_	_	_	_	_	_	_	_
322	is	_	_	_	_	_	_	_	_
323	mainly	_	_	_	_	_	_	_	_
324	active	_	_	_	_	_	_	_	_
325	during	_	_	_	_	_	_	_	_
326	the	_	_	_	_	_	_	_	_
327	early	_	_	_	_	_	_	_	_
328	entry	_	_	_	_	_	_	_	_
329	phase	_	_	_	_	_	_	_	_
330	of	_	_	_	_	_	_	_	_
331	RSV	_	_	_	_	_	_	_	_
332	.	_	_	_	_	_	_	_	_
333	The	_	_	_	_	_	_	_	BeginSeg=Yes
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335	effect	_	_	_	_	_	_	_	_
336	was	_	_	_	_	_	_	_	_
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338	observed	_	_	_	_	_	_	_	_
339	with	_	_	_	_	_	_	_	_
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344	-	_	_	_	_	_	_	_	_
345	2	_	_	_	_	_	_	_	_
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347	A2000/3	_	_	_	_	_	_	_	_
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349	4	_	_	_	_	_	_	_	_
350	,	_	_	_	_	_	_	_	_
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352	that	_	_	_	_	_	_	_	BeginSeg=Yes
353	this	_	_	_	_	_	_	_	_
354	is	_	_	_	_	_	_	_	_
355	a	_	_	_	_	_	_	_	_
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360	.	_	_	_	_	_	_	_	_
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362	:	_	_	_	_	_	_	_	_
363	RSV	_	_	_	_	_	_	_	BeginSeg=Yes
364	infection	_	_	_	_	_	_	_	_
365	can	_	_	_	_	_	_	_	_
366	be	_	_	_	_	_	_	_	_
367	inhibited	_	_	_	_	_	_	_	_
368	by	_	_	_	_	_	_	_	_
369	broad	_	_	_	_	_	_	_	_
370	serine	_	_	_	_	_	_	_	_
371	protease	_	_	_	_	_	_	_	_
372	inhibitors	_	_	_	_	_	_	_	_
373	,	_	_	_	_	_	_	_	_
374	AEBSF	_	_	_	_	_	_	_	_
375	and	_	_	_	_	_	_	_	_
376	TPCK	_	_	_	_	_	_	_	_
377	.	_	_	_	_	_	_	_	_
378	We	_	_	_	_	_	_	_	BeginSeg=Yes
379	confirmed	_	_	_	_	_	_	_	_
380	that	_	_	_	_	_	_	_	BeginSeg=Yes
381	AEBSF	_	_	_	_	_	_	_	_
382	inhibition	_	_	_	_	_	_	_	_
383	is	_	_	_	_	_	_	_	_
384	independent	_	_	_	_	_	_	_	_
385	of	_	_	_	_	_	_	_	_
386	the	_	_	_	_	_	_	_	_
387	cell	_	_	_	_	_	_	_	_
388	line	_	_	_	_	_	_	_	_
389	used	_	_	_	_	_	_	_	BeginSeg=Yes
390	or	_	_	_	_	_	_	_	_
391	RSV	_	_	_	_	_	_	_	_
392	strain	_	_	_	_	_	_	_	_
393	.	_	_	_	_	_	_	_	_
394	The	_	_	_	_	_	_	_	BeginSeg=Yes
395	time	_	_	_	_	_	_	_	_
396	point	_	_	_	_	_	_	_	_
397	at	_	_	_	_	_	_	_	BeginSeg=Yes
398	which	_	_	_	_	_	_	_	_
399	treatment	_	_	_	_	_	_	_	_
400	with	_	_	_	_	_	_	_	_
401	the	_	_	_	_	_	_	_	_
402	inhibitor	_	_	_	_	_	_	_	_
403	was	_	_	_	_	_	_	_	_
404	most	_	_	_	_	_	_	_	_
405	potent	_	_	_	_	_	_	_	_
406	,	_	_	_	_	_	_	_	_
407	was	_	_	_	_	_	_	_	BeginSeg=Yes
408	found	_	_	_	_	_	_	_	_
409	to	_	_	_	_	_	_	_	_
410	coincide	_	_	_	_	_	_	_	_
411	with	_	_	_	_	_	_	_	_
412	the	_	_	_	_	_	_	_	_
413	expected	_	_	_	_	_	_	_	_
414	moment	_	_	_	_	_	_	_	_
415	of	_	_	_	_	_	_	_	_
416	entry	_	_	_	_	_	_	_	_
417	of	_	_	_	_	_	_	_	_
418	the	_	_	_	_	_	_	_	_
419	virion	_	_	_	_	_	_	_	_
420	with	_	_	_	_	_	_	_	_
421	the	_	_	_	_	_	_	_	_
422	host	_	_	_	_	_	_	_	_
423	cell	_	_	_	_	_	_	_	_
424	.	_	_	_	_	_	_	_	_

# newdoc_id = 0a91a01d3b6084bfd02cacba098af54c2e38f374
1	Basing	_	_	_	_	_	_	_	BeginSeg=Yes
2	on	_	_	_	_	_	_	_	_
3	existence	_	_	_	_	_	_	_	_
4	of	_	_	_	_	_	_	_	_
5	the	_	_	_	_	_	_	_	_
6	mathematically	_	_	_	_	_	_	_	_
7	sequential	_	_	_	_	_	_	_	_
8	reduction	_	_	_	_	_	_	_	_
9	of	_	_	_	_	_	_	_	_
10	the	_	_	_	_	_	_	_	_
11	three	_	_	_	_	_	_	_	_
12	-	_	_	_	_	_	_	_	_
13	compartmental	_	_	_	_	_	_	_	_
14	(	_	_	_	_	_	_	_	BeginSeg=Yes
15	Susceptible	_	_	_	_	_	_	_	_
16	-	_	_	_	_	_	_	_	_
17	Infected	_	_	_	_	_	_	_	_
18	-	_	_	_	_	_	_	_	_
19	Recovered	_	_	_	_	_	_	_	_
20	/	_	_	_	_	_	_	_	_
21	Removed	_	_	_	_	_	_	_	_
22	)	_	_	_	_	_	_	_	_
23	model	_	_	_	_	_	_	_	BeginSeg=Yes
24	to	_	_	_	_	_	_	_	_
25	the	_	_	_	_	_	_	_	_
26	Verhulst	_	_	_	_	_	_	_	_
27	(	_	_	_	_	_	_	_	_
28	logistic	_	_	_	_	_	_	_	_
29	)	_	_	_	_	_	_	_	_
30	equation	_	_	_	_	_	_	_	_
31	with	_	_	_	_	_	_	_	_
32	the	_	_	_	_	_	_	_	_
33	parameters	_	_	_	_	_	_	_	_
34	determined	_	_	_	_	_	_	_	BeginSeg=Yes
35	by	_	_	_	_	_	_	_	_
36	the	_	_	_	_	_	_	_	_
37	basic	_	_	_	_	_	_	_	_
38	characteristic	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	epidemic	_	_	_	_	_	_	_	_
41	process	_	_	_	_	_	_	_	_
42	,	_	_	_	_	_	_	_	_
43	this	_	_	_	_	_	_	_	BeginSeg=Yes
44	model	_	_	_	_	_	_	_	_
45	is	_	_	_	_	_	_	_	_
46	tested	_	_	_	_	_	_	_	_
47	in	_	_	_	_	_	_	_	_
48	application	_	_	_	_	_	_	_	_
49	to	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	recent	_	_	_	_	_	_	_	_
52	data	_	_	_	_	_	_	_	_
53	on	_	_	_	_	_	_	_	_
54	COVID-19	_	_	_	_	_	_	_	_
55	outbreak	_	_	_	_	_	_	_	_
56	reported	_	_	_	_	_	_	_	BeginSeg=Yes
57	by	_	_	_	_	_	_	_	_
58	the	_	_	_	_	_	_	_	_
59	European	_	_	_	_	_	_	_	_
60	Centre	_	_	_	_	_	_	_	_
61	for	_	_	_	_	_	_	_	_
62	Disease	_	_	_	_	_	_	_	_
63	Prevention	_	_	_	_	_	_	_	_
64	and	_	_	_	_	_	_	_	_
65	Control	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	It	_	_	_	_	_	_	_	BeginSeg=Yes
68	is	_	_	_	_	_	_	_	_
69	shown	_	_	_	_	_	_	_	_
70	that	_	_	_	_	_	_	_	_
71	such	_	_	_	_	_	_	_	_
72	a	_	_	_	_	_	_	_	_
73	simple	_	_	_	_	_	_	_	_
74	model	_	_	_	_	_	_	_	_
75	adequately	_	_	_	_	_	_	_	_
76	reproduces	_	_	_	_	_	_	_	_
77	the	_	_	_	_	_	_	_	_
78	epidemic	_	_	_	_	_	_	_	_
79	dynamics	_	_	_	_	_	_	_	_
80	not	_	_	_	_	_	_	_	_
81	only	_	_	_	_	_	_	_	_
82	qualitatively	_	_	_	_	_	_	_	_
83	but	_	_	_	_	_	_	_	_
84	for	_	_	_	_	_	_	_	_
85	a	_	_	_	_	_	_	_	_
86	number	_	_	_	_	_	_	_	_
87	of	_	_	_	_	_	_	_	_
88	countries	_	_	_	_	_	_	_	_
89	quantitatively	_	_	_	_	_	_	_	_
90	with	_	_	_	_	_	_	_	_
91	a	_	_	_	_	_	_	_	_
92	high	_	_	_	_	_	_	_	_
93	degree	_	_	_	_	_	_	_	_
94	of	_	_	_	_	_	_	_	_
95	correlation	_	_	_	_	_	_	_	_
96	that	_	_	_	_	_	_	_	BeginSeg=Yes
97	allows	_	_	_	_	_	_	_	_
98	to	_	_	_	_	_	_	_	_
99	use	_	_	_	_	_	_	_	_
100	it	_	_	_	_	_	_	_	_
101	for	_	_	_	_	_	_	_	_
102	predictive	_	_	_	_	_	_	_	_
103	estimations	_	_	_	_	_	_	_	_
104	.	_	_	_	_	_	_	_	_
105	In	_	_	_	_	_	_	_	BeginSeg=Yes
106	addition	_	_	_	_	_	_	_	_
107	,	_	_	_	_	_	_	_	_
108	some	_	_	_	_	_	_	_	_
109	features	_	_	_	_	_	_	_	_
110	of	_	_	_	_	_	_	_	_
111	SIR	_	_	_	_	_	_	_	_
112	model	_	_	_	_	_	_	_	_
113	are	_	_	_	_	_	_	_	_
114	discussed	_	_	_	_	_	_	_	_
115	in	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	_
117	context	_	_	_	_	_	_	_	_
118	,	_	_	_	_	_	_	_	_
119	how	_	_	_	_	_	_	_	BeginSeg=Yes
120	its	_	_	_	_	_	_	_	_
121	parameters	_	_	_	_	_	_	_	_
122	and	_	_	_	_	_	_	_	_
123	conditions	_	_	_	_	_	_	_	_
124	reflect	_	_	_	_	_	_	_	_
125	measures	_	_	_	_	_	_	_	_
126	attempted	_	_	_	_	_	_	_	BeginSeg=Yes
127	for	_	_	_	_	_	_	_	_
128	the	_	_	_	_	_	_	_	_
129	disease	_	_	_	_	_	_	_	_
130	growth	_	_	_	_	_	_	_	_
131	prevention	_	_	_	_	_	_	_	_
132	that	_	_	_	_	_	_	_	BeginSeg=Yes
133	is	_	_	_	_	_	_	_	_
134	also	_	_	_	_	_	_	_	_
135	clearly	_	_	_	_	_	_	_	_
136	indicated	_	_	_	_	_	_	_	_
137	by	_	_	_	_	_	_	_	_
138	deviations	_	_	_	_	_	_	_	_
139	from	_	_	_	_	_	_	_	_
140	such	_	_	_	_	_	_	_	_
141	model	_	_	_	_	_	_	_	_
142	solutions	_	_	_	_	_	_	_	_
143	.	_	_	_	_	_	_	_	_

# newdoc_id = 0b47e798d50ce617982cb6f89dc887fb829b0fe2
1	Background	_	_	_	_	_	_	_	BeginSeg=Yes
2	:	_	_	_	_	_	_	_	_
3	Due	_	_	_	_	_	_	_	BeginSeg=Yes
4	to	_	_	_	_	_	_	_	_
5	the	_	_	_	_	_	_	_	_
6	covid-19	_	_	_	_	_	_	_	_
7	outbreak	_	_	_	_	_	_	_	_
8	,	_	_	_	_	_	_	_	_
9	social	_	_	_	_	_	_	_	_
10	distancing	_	_	_	_	_	_	_	_
11	measures	_	_	_	_	_	_	_	_
12	were	_	_	_	_	_	_	_	_
13	imposed	_	_	_	_	_	_	_	_
14	to	_	_	_	_	_	_	_	BeginSeg=Yes
15	control	_	_	_	_	_	_	_	_
16	the	_	_	_	_	_	_	_	_
17	spread	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	the	_	_	_	_	_	_	_	_
20	pandemic	_	_	_	_	_	_	_	_
21	.	_	_	_	_	_	_	_	_
22	However	_	_	_	_	_	_	_	BeginSeg=Yes
23	,	_	_	_	_	_	_	_	_
24	isolation	_	_	_	_	_	_	_	_
25	may	_	_	_	_	_	_	_	_
26	affect	_	_	_	_	_	_	_	_
27	negatively	_	_	_	_	_	_	_	_
28	the	_	_	_	_	_	_	_	_
29	psychological	_	_	_	_	_	_	_	_
30	well	_	_	_	_	_	_	_	_
31	-	_	_	_	_	_	_	_	_
32	being	_	_	_	_	_	_	_	_
33	and	_	_	_	_	_	_	_	_
34	impair	_	_	_	_	_	_	_	_
35	sleep	_	_	_	_	_	_	_	_
36	quality	_	_	_	_	_	_	_	_
37	.	_	_	_	_	_	_	_	_
38	Our	_	_	_	_	_	_	_	BeginSeg=Yes
39	aim	_	_	_	_	_	_	_	_
40	was	_	_	_	_	_	_	_	_
41	to	_	_	_	_	_	_	_	_
42	evaluate	_	_	_	_	_	_	_	_
43	the	_	_	_	_	_	_	_	_
44	sleep	_	_	_	_	_	_	_	_
45	quality	_	_	_	_	_	_	_	_
46	of	_	_	_	_	_	_	_	_
47	respiratory	_	_	_	_	_	_	_	_
48	patients	_	_	_	_	_	_	_	_
49	during	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	covid-19	_	_	_	_	_	_	_	_
52	pandemic	_	_	_	_	_	_	_	_
53	lockdown	_	_	_	_	_	_	_	_
54	.	_	_	_	_	_	_	_	_

# newdoc_id = 0b5b490f075aa99ce120a49126ba2ebd1e86dba7
1	Immunological	_	_	_	_	_	_	_	BeginSeg=Yes
2	impairment	_	_	_	_	_	_	_	_
3	by	_	_	_	_	_	_	_	_
4	porcine	_	_	_	_	_	_	_	_
5	circovirus	_	_	_	_	_	_	_	_
6	type	_	_	_	_	_	_	_	_
7	2	_	_	_	_	_	_	_	_
8	(	_	_	_	_	_	_	_	_
9	PCV2	_	_	_	_	_	_	_	_
10	)	_	_	_	_	_	_	_	_
11	infection	_	_	_	_	_	_	_	_
12	is	_	_	_	_	_	_	_	_
13	well	_	_	_	_	_	_	_	_
14	documented	_	_	_	_	_	_	_	_
15	in	_	_	_	_	_	_	_	_
16	pigs	_	_	_	_	_	_	_	_
17	suffering	_	_	_	_	_	_	_	BeginSeg=Yes
18	from	_	_	_	_	_	_	_	_
19	postweaning	_	_	_	_	_	_	_	_
20	multisystemic	_	_	_	_	_	_	_	_
21	wasting	_	_	_	_	_	_	_	_
22	syndrome	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
24	Nonetheless	_	_	_	_	_	_	_	BeginSeg=Yes
25	,	_	_	_	_	_	_	_	_
26	little	_	_	_	_	_	_	_	_
27	is	_	_	_	_	_	_	_	_
28	known	_	_	_	_	_	_	_	_
29	about	_	_	_	_	_	_	_	_
30	immune	_	_	_	_	_	_	_	_
31	status	_	_	_	_	_	_	_	_
32	of	_	_	_	_	_	_	_	_
33	pigs	_	_	_	_	_	_	_	_
34	that	_	_	_	_	_	_	_	BeginSeg=Yes
35	remain	_	_	_	_	_	_	_	_
36	PCV2	_	_	_	_	_	_	_	_
37	subclinically	_	_	_	_	_	_	_	_
38	infected	_	_	_	_	_	_	_	_
39	.	_	_	_	_	_	_	_	_
40	Thus	_	_	_	_	_	_	_	BeginSeg=Yes
41	,	_	_	_	_	_	_	_	_
42	seven	_	_	_	_	_	_	_	_
43	pigs	_	_	_	_	_	_	_	_
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45	infected	_	_	_	_	_	_	_	_
46	in	_	_	_	_	_	_	_	_
47	an	_	_	_	_	_	_	_	_
48	experimental	_	_	_	_	_	_	_	_
49	inoculation	_	_	_	_	_	_	_	_
50	and	_	_	_	_	_	_	_	_
51	without	_	_	_	_	_	_	_	_
52	developing	_	_	_	_	_	_	_	_
53	disease	_	_	_	_	_	_	_	_
54	and	_	_	_	_	_	_	_	BeginSeg=Yes
55	nine	_	_	_	_	_	_	_	_
56	control	_	_	_	_	_	_	_	_
57	non	_	_	_	_	_	_	_	_
58	-	_	_	_	_	_	_	_	_
59	inoculated	_	_	_	_	_	_	_	_
60	pigs	_	_	_	_	_	_	_	_
61	were	_	_	_	_	_	_	_	_
62	examined	_	_	_	_	_	_	_	_
63	.	_	_	_	_	_	_	_	_
64	Serological	_	_	_	_	_	_	_	BeginSeg=Yes
65	,	_	_	_	_	_	_	_	_
66	virological	_	_	_	_	_	_	_	_
67	and	_	_	_	_	_	_	_	_
68	immunological	_	_	_	_	_	_	_	_
69	determinations	_	_	_	_	_	_	_	_
70	were	_	_	_	_	_	_	_	_
71	done	_	_	_	_	_	_	_	_
72	throughout	_	_	_	_	_	_	_	_
73	ten	_	_	_	_	_	_	_	_
74	weeks	_	_	_	_	_	_	_	_
75	post	_	_	_	_	_	_	_	_
76	-	_	_	_	_	_	_	_	_
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78	(	_	_	_	_	_	_	_	_
79	PI	_	_	_	_	_	_	_	_
80	)	_	_	_	_	_	_	_	_
81	.	_	_	_	_	_	_	_	_
82	At	_	_	_	_	_	_	_	BeginSeg=Yes
83	week	_	_	_	_	_	_	_	_
84	3	_	_	_	_	_	_	_	_
85	PI	_	_	_	_	_	_	_	_
86	,	_	_	_	_	_	_	_	_
87	inoculated	_	_	_	_	_	_	_	_
88	animals	_	_	_	_	_	_	_	_
89	presented	_	_	_	_	_	_	_	_
90	the	_	_	_	_	_	_	_	_
91	peak	_	_	_	_	_	_	_	_
92	of	_	_	_	_	_	_	_	_
93	viremia	_	_	_	_	_	_	_	_
94	and	_	_	_	_	_	_	_	BeginSeg=Yes
95	produced	_	_	_	_	_	_	_	_
96	higher	_	_	_	_	_	_	_	_
97	levels	_	_	_	_	_	_	_	_
98	of	_	_	_	_	_	_	_	_
99	IL-10	_	_	_	_	_	_	_	_
100	than	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	controls	_	_	_	_	_	_	_	_
103	;	_	_	_	_	_	_	_	_
104	correlation	_	_	_	_	_	_	_	BeginSeg=Yes
105	between	_	_	_	_	_	_	_	_
106	viral	_	_	_	_	_	_	_	_
107	load	_	_	_	_	_	_	_	_
108	and	_	_	_	_	_	_	_	_
109	IL-10	_	_	_	_	_	_	_	_
110	amounts	_	_	_	_	_	_	_	_
111	was	_	_	_	_	_	_	_	_
112	observed	_	_	_	_	_	_	_	_
113	(	_	_	_	_	_	_	_	BeginSeg=Yes
114	p	_	_	_	_	_	_	_	_
115	<	_	_	_	_	_	_	_	_
116	0.05	_	_	_	_	_	_	_	_
117	)	_	_	_	_	_	_	_	_
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143	of	_	_	_	_	_	_	_	_
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150	.	_	_	_	_	_	_	_	_
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152	summary	_	_	_	_	_	_	_	_
153	,	_	_	_	_	_	_	_	_
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155	PCV2-infected	_	_	_	_	_	_	_	_
156	pigs	_	_	_	_	_	_	_	_
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158	a	_	_	_	_	_	_	_	_
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161	IL-10	_	_	_	_	_	_	_	_
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41	mitigate	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
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52	DHCPS	_	_	_	_	_	_	_	_
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63	safe	_	_	_	_	_	_	_	_
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67	dental	_	_	_	_	_	_	_	_
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71	normalcy	_	_	_	_	_	_	_	_
72	.	_	_	_	_	_	_	_	_
73	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
74	topic	_	_	_	_	_	_	_	_
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76	as	_	_	_	_	_	_	_	_
77	fit	_	_	_	_	_	_	_	_
78	testing	_	_	_	_	_	_	_	_
79	,	_	_	_	_	_	_	_	_
80	contact	_	_	_	_	_	_	_	_
81	tracing	_	_	_	_	_	_	_	_
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84	health	_	_	_	_	_	_	_	_
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88	discussed	_	_	_	_	_	_	_	_
89	and	_	_	_	_	_	_	_	BeginSeg=Yes
90	experience	_	_	_	_	_	_	_	_
91	of	_	_	_	_	_	_	_	_
92	such	_	_	_	_	_	_	_	_
93	measures	_	_	_	_	_	_	_	_
94	is	_	_	_	_	_	_	_	_
95	shared	_	_	_	_	_	_	_	_
96	.	_	_	_	_	_	_	_	_
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99	hoped	_	_	_	_	_	_	_	_
100	that	_	_	_	_	_	_	_	_
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102	the	_	_	_	_	_	_	_	_
103	time	_	_	_	_	_	_	_	_
104	new	_	_	_	_	_	_	_	_
105	evidence	_	_	_	_	_	_	_	_
106	based	_	_	_	_	_	_	_	_
107	data	_	_	_	_	_	_	_	_
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109	generated	_	_	_	_	_	_	_	_
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111	communications	_	_	_	_	_	_	_	_
112	may	_	_	_	_	_	_	_	_
113	help	_	_	_	_	_	_	_	_
114	spread	_	_	_	_	_	_	_	_
115	awareness	_	_	_	_	_	_	_	_
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117	help	_	_	_	_	_	_	_	_
118	setup	_	_	_	_	_	_	_	_
119	clinical	_	_	_	_	_	_	_	_
120	protocols	_	_	_	_	_	_	_	_
121	for	_	_	_	_	_	_	_	_
122	other	_	_	_	_	_	_	_	_
123	tertiary	_	_	_	_	_	_	_	_
124	care	_	_	_	_	_	_	_	_
125	settings	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_

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8	been	_	_	_	_	_	_	_	_
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11	verified	_	_	_	_	_	_	_	_
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14	very	_	_	_	_	_	_	_	_
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21	bacteria	_	_	_	_	_	_	_	_
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23	fungi	_	_	_	_	_	_	_	_
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36	even	_	_	_	_	_	_	_	_
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96	this	_	_	_	_	_	_	_	_
97	paper	_	_	_	_	_	_	_	_
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167	equipment	_	_	_	_	_	_	_	_
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170	bioaerosols	_	_	_	_	_	_	_	_
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68	,	_	_	_	_	_	_	_	_
69	pericytes	_	_	_	_	_	_	_	_
70	provoke	_	_	_	_	_	_	_	_
71	immune	_	_	_	_	_	_	_	_
72	cells	_	_	_	_	_	_	_	_
73	to	_	_	_	_	_	_	_	_
74	regulate	_	_	_	_	_	_	_	_
75	neuro	_	_	_	_	_	_	_	_
76	-	_	_	_	_	_	_	_	_
77	inflammatory	_	_	_	_	_	_	_	_
78	conditions	_	_	_	_	_	_	_	_
79	.	_	_	_	_	_	_	_	_
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81	of	_	_	_	_	_	_	_	_
82	pericytes	_	_	_	_	_	_	_	_
83	in	_	_	_	_	_	_	_	_
84	distinct	_	_	_	_	_	_	_	_
85	neurologic	_	_	_	_	_	_	_	_
86	disorders	_	_	_	_	_	_	_	_
87	intensifies	_	_	_	_	_	_	_	_
88	blood	_	_	_	_	_	_	_	_
89	-	_	_	_	_	_	_	_	_
90	brain	_	_	_	_	_	_	_	_
91	barrier	_	_	_	_	_	_	_	_
92	permeability	_	_	_	_	_	_	_	_
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94	leads	_	_	_	_	_	_	_	_
95	to	_	_	_	_	_	_	_	_
96	vascular	_	_	_	_	_	_	_	_
97	dementia	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	The	_	_	_	_	_	_	_	BeginSeg=Yes
100	therapeutic	_	_	_	_	_	_	_	_
101	potential	_	_	_	_	_	_	_	_
102	of	_	_	_	_	_	_	_	_
103	pericytes	_	_	_	_	_	_	_	_
104	is	_	_	_	_	_	_	_	_
105	originated	_	_	_	_	_	_	_	_
106	from	_	_	_	_	_	_	_	_
107	the	_	_	_	_	_	_	_	_
108	unique	_	_	_	_	_	_	_	_
109	morphological	_	_	_	_	_	_	_	_
110	shape	_	_	_	_	_	_	_	_
111	,	_	_	_	_	_	_	_	_
112	location	_	_	_	_	_	_	_	_
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114	and	_	_	_	_	_	_	_	_
115	their	_	_	_	_	_	_	_	_
116	ability	_	_	_	_	_	_	_	_
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118	providing	_	_	_	_	_	_	_	_
119	vast	_	_	_	_	_	_	_	_
120	paracrine	_	_	_	_	_	_	_	_
121	and	_	_	_	_	_	_	_	_
122	juxtacrine	_	_	_	_	_	_	_	_
123	interactions	_	_	_	_	_	_	_	_
124	.	_	_	_	_	_	_	_	_
125	A	_	_	_	_	_	_	_	BeginSeg=Yes
126	subset	_	_	_	_	_	_	_	_
127	of	_	_	_	_	_	_	_	_
128	pericytes	_	_	_	_	_	_	_	_
129	possesses	_	_	_	_	_	_	_	_
130	multipotentiality	_	_	_	_	_	_	_	_
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132	exhibit	_	_	_	_	_	_	_	_
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136	capacity	_	_	_	_	_	_	_	_
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145	review	_	_	_	_	_	_	_	_
146	article	_	_	_	_	_	_	_	_
147	aimed	_	_	_	_	_	_	_	_
148	to	_	_	_	_	_	_	_	_
149	highlight	_	_	_	_	_	_	_	_
150	the	_	_	_	_	_	_	_	_
151	critical	_	_	_	_	_	_	_	_
152	role	_	_	_	_	_	_	_	_
153	of	_	_	_	_	_	_	_	_
154	pericytes	_	_	_	_	_	_	_	_
155	in	_	_	_	_	_	_	_	_
156	restoration	_	_	_	_	_	_	_	_
157	of	_	_	_	_	_	_	_	_
158	the	_	_	_	_	_	_	_	_
159	blood	_	_	_	_	_	_	_	_
160	-	_	_	_	_	_	_	_	_
161	brain	_	_	_	_	_	_	_	_
162	barrier	_	_	_	_	_	_	_	_
163	after	_	_	_	_	_	_	_	_
164	injury	_	_	_	_	_	_	_	_
165	by	_	_	_	_	_	_	_	BeginSeg=Yes
166	focusing	_	_	_	_	_	_	_	_
167	on	_	_	_	_	_	_	_	_
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169	dynamics	_	_	_	_	_	_	_	_
170	of	_	_	_	_	_	_	_	_
171	pericytes	_	_	_	_	_	_	_	_
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173	cross	_	_	_	_	_	_	_	_
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175	talk	_	_	_	_	_	_	_	_
176	with	_	_	_	_	_	_	_	_
177	other	_	_	_	_	_	_	_	_
178	cell	_	_	_	_	_	_	_	_
179	types	_	_	_	_	_	_	_	_
180	.	_	_	_	_	_	_	_	_

# newdoc_id = 123589feb77f17e27c7b93326aaae484bff34424
1	This	_	_	_	_	_	_	_	BeginSeg=Yes
2	study	_	_	_	_	_	_	_	_
3	is	_	_	_	_	_	_	_	_
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6	defining	_	_	_	_	_	_	_	_
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11	set	_	_	_	_	_	_	_	_
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14	factors	_	_	_	_	_	_	_	_
15	and	_	_	_	_	_	_	_	_
16	childhood	_	_	_	_	_	_	_	_
17	HFMD	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	_
19	then	_	_	_	_	_	_	_	_
20	at	_	_	_	_	_	_	_	_
21	estimating	_	_	_	_	_	_	_	_
22	the	_	_	_	_	_	_	_	_
23	related	_	_	_	_	_	_	_	_
24	effect	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	The	_	_	_	_	_	_	_	BeginSeg=Yes
27	16	_	_	_	_	_	_	_	_
28	environmental	_	_	_	_	_	_	_	_
29	factors	_	_	_	_	_	_	_	_
30	included	_	_	_	_	_	_	_	_
31	meteorological	_	_	_	_	_	_	_	_
32	,	_	_	_	_	_	_	_	_
33	air	_	_	_	_	_	_	_	_
34	pollution	_	_	_	_	_	_	_	_
35	,	_	_	_	_	_	_	_	_
36	and	_	_	_	_	_	_	_	_
37	sunspot	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
39	A	_	_	_	_	_	_	_	BeginSeg=Yes
40	traditional	_	_	_	_	_	_	_	_
41	TSR	_	_	_	_	_	_	_	_
42	modified	_	_	_	_	_	_	_	BeginSeg=Yes
43	by	_	_	_	_	_	_	_	BeginSeg=Yes
44	using	_	_	_	_	_	_	_	_
45	susceptible	_	_	_	_	_	_	_	_
46	-	_	_	_	_	_	_	_	_
47	infectious	_	_	_	_	_	_	_	_
48	-	_	_	_	_	_	_	_	_
49	recovery	_	_	_	_	_	_	_	_
50	models	_	_	_	_	_	_	_	_
51	and	_	_	_	_	_	_	_	_
52	distribution	_	_	_	_	_	_	_	_
53	lag	_	_	_	_	_	_	_	_
54	nonlinear	_	_	_	_	_	_	_	_
55	model	_	_	_	_	_	_	_	_
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57	applied	_	_	_	_	_	_	_	_
58	to	_	_	_	_	_	_	_	BeginSeg=Yes
59	estimate	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	short	_	_	_	_	_	_	_	_
62	-	_	_	_	_	_	_	_	_
63	term	_	_	_	_	_	_	_	_
64	effects	_	_	_	_	_	_	_	_
65	of	_	_	_	_	_	_	_	_
66	daily	_	_	_	_	_	_	_	_
67	environmental	_	_	_	_	_	_	_	_
68	factors	_	_	_	_	_	_	_	_
69	on	_	_	_	_	_	_	_	_
70	children	_	_	_	_	_	_	_	_
71	HFMD	_	_	_	_	_	_	_	_
72	occurrence	_	_	_	_	_	_	_	_
73	in	_	_	_	_	_	_	_	_
74	2014	_	_	_	_	_	_	_	_
75	-	_	_	_	_	_	_	_	_
76	2018	_	_	_	_	_	_	_	_
77	with	_	_	_	_	_	_	_	_
78	adjustment	_	_	_	_	_	_	_	_
79	of	_	_	_	_	_	_	_	_
80	potential	_	_	_	_	_	_	_	_
81	confounding	_	_	_	_	_	_	_	_
82	factors	_	_	_	_	_	_	_	_
83	.	_	_	_	_	_	_	_	_
84	A	_	_	_	_	_	_	_	BeginSeg=Yes
85	total	_	_	_	_	_	_	_	_
86	of	_	_	_	_	_	_	_	_
87	70,027	_	_	_	_	_	_	_	_
88	children	_	_	_	_	_	_	_	_
89	aged	_	_	_	_	_	_	_	_
90	0	_	_	_	_	_	_	_	_
91	-	_	_	_	_	_	_	_	_
92	15	_	_	_	_	_	_	_	_
93	years	_	_	_	_	_	_	_	_
94	with	_	_	_	_	_	_	_	_
95	HFMD	_	_	_	_	_	_	_	_
96	were	_	_	_	_	_	_	_	_
97	enrolled	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	No	_	_	_	_	_	_	_	BeginSeg=Yes
100	significant	_	_	_	_	_	_	_	_
101	effect	_	_	_	_	_	_	_	_
102	was	_	_	_	_	_	_	_	_
103	observed	_	_	_	_	_	_	_	_
104	for	_	_	_	_	_	_	_	_
105	daily	_	_	_	_	_	_	_	_
106	sunspot	_	_	_	_	_	_	_	_
107	numbers	_	_	_	_	_	_	_	_
108	and	_	_	_	_	_	_	_	_
109	average	_	_	_	_	_	_	_	_
110	visibility	_	_	_	_	_	_	_	_
111	.	_	_	_	_	_	_	_	_
112	We	_	_	_	_	_	_	_	BeginSeg=Yes
113	found	_	_	_	_	_	_	_	_
114	positive	_	_	_	_	_	_	_	_
115	effects	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	the	_	_	_	_	_	_	_	_
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119	average	_	_	_	_	_	_	_	_
120	temperature	_	_	_	_	_	_	_	_
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123	an	_	_	_	_	_	_	_	_
124	approximately	_	_	_	_	_	_	_	_
125	m	_	_	_	_	_	_	_	_
126	-	_	_	_	_	_	_	_	_
127	shaped	_	_	_	_	_	_	_	_
128	curve	_	_	_	_	_	_	_	_
129	of	_	_	_	_	_	_	_	_
130	the	_	_	_	_	_	_	_	_
131	overall	_	_	_	_	_	_	_	_
132	cumulative	_	_	_	_	_	_	_	_
133	relationship	_	_	_	_	_	_	_	_
134	,	_	_	_	_	_	_	_	_
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136	at	_	_	_	_	_	_	_	_
137	25.6	_	_	_	_	_	_	_	_
138	°	_	_	_	_	_	_	_	_
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146	)	_	_	_	_	_	_	_	_
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148	1.45	_	_	_	_	_	_	_	_
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150	95	_	_	_	_	_	_	_	_
151	%	_	_	_	_	_	_	_	_
152	confidence	_	_	_	_	_	_	_	_
153	intervals	_	_	_	_	_	_	_	_
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155	-	_	_	_	_	_	_	_	_
156	1.73	_	_	_	_	_	_	_	_
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158	.	_	_	_	_	_	_	_	_
159	The	_	_	_	_	_	_	_	BeginSeg=Yes
160	largest	_	_	_	_	_	_	_	_
161	RR	_	_	_	_	_	_	_	_
162	value	_	_	_	_	_	_	_	_
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164	hot	_	_	_	_	_	_	_	_
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167	achieved	_	_	_	_	_	_	_	_
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259	confirm	_	_	_	_	_	_	_	_
260	these	_	_	_	_	_	_	_	_
261	findings	_	_	_	_	_	_	_	_
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44	South	_	_	_	_	_	_	_	_
45	Korea	_	_	_	_	_	_	_	_
46	during	_	_	_	_	_	_	_	_
47	2010/11	_	_	_	_	_	_	_	_
48	were	_	_	_	_	_	_	_	BeginSeg=Yes
49	analyzed	_	_	_	_	_	_	_	_
50	using	_	_	_	_	_	_	_	BeginSeg=Yes
51	RT	_	_	_	_	_	_	_	_
52	-	_	_	_	_	_	_	_	_
53	PCR	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	revealing	_	_	_	_	_	_	_	BeginSeg=Yes
56	a	_	_	_	_	_	_	_	_
57	PEDV	_	_	_	_	_	_	_	_
58	infection	_	_	_	_	_	_	_	_
59	rate	_	_	_	_	_	_	_	_
60	of	_	_	_	_	_	_	_	_
61	9.75	_	_	_	_	_	_	_	_
62	%	_	_	_	_	_	_	_	_
63	(	_	_	_	_	_	_	_	_
64	28/287	_	_	_	_	_	_	_	_
65	)	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	PEDV	_	_	_	_	_	_	_	BeginSeg=Yes
68	positive	_	_	_	_	_	_	_	_
69	samples	_	_	_	_	_	_	_	_
70	were	_	_	_	_	_	_	_	_
71	distributed	_	_	_	_	_	_	_	_
72	throughout	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	mainland	_	_	_	_	_	_	_	_
75	of	_	_	_	_	_	_	_	_
76	South	_	_	_	_	_	_	_	_
77	Korea	_	_	_	_	_	_	_	_
78	,	_	_	_	_	_	_	_	_
79	clustering	_	_	_	_	_	_	_	BeginSeg=Yes
80	at	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	northern	_	_	_	_	_	_	_	_
83	border	_	_	_	_	_	_	_	_
84	adjacent	_	_	_	_	_	_	_	_
85	to	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	Demilitarized	_	_	_	_	_	_	_	_
88	Zone	_	_	_	_	_	_	_	_
89	(	_	_	_	_	_	_	_	_
90	DMZ	_	_	_	_	_	_	_	_
91	)	_	_	_	_	_	_	_	_
92	and	_	_	_	_	_	_	_	_
93	in	_	_	_	_	_	_	_	_
94	mountainous	_	_	_	_	_	_	_	_
95	regions	_	_	_	_	_	_	_	_
96	.	_	_	_	_	_	_	_	_
97	PEDV	_	_	_	_	_	_	_	BeginSeg=Yes
98	in	_	_	_	_	_	_	_	_
99	wild	_	_	_	_	_	_	_	_
100	boar	_	_	_	_	_	_	_	_
101	was	_	_	_	_	_	_	_	_
102	genetically	_	_	_	_	_	_	_	_
103	similar	_	_	_	_	_	_	_	_
104	to	_	_	_	_	_	_	_	_
105	Chinese	_	_	_	_	_	_	_	_
106	PEDV	_	_	_	_	_	_	_	_
107	strains	_	_	_	_	_	_	_	_
108	in	_	_	_	_	_	_	_	_
109	phylogenetic	_	_	_	_	_	_	_	_
110	investigations	_	_	_	_	_	_	_	_
111	.	_	_	_	_	_	_	_	_
112	Our	_	_	_	_	_	_	_	BeginSeg=Yes
113	results	_	_	_	_	_	_	_	_
114	indicated	_	_	_	_	_	_	_	_
115	that	_	_	_	_	_	_	_	BeginSeg=Yes
116	PEDV	_	_	_	_	_	_	_	_
117	is	_	_	_	_	_	_	_	_
118	circulating	_	_	_	_	_	_	_	_
119	in	_	_	_	_	_	_	_	_
120	the	_	_	_	_	_	_	_	_
121	wild	_	_	_	_	_	_	_	_
122	boar	_	_	_	_	_	_	_	_
123	and	_	_	_	_	_	_	_	BeginSeg=Yes
124	provided	_	_	_	_	_	_	_	_
125	a	_	_	_	_	_	_	_	_
126	novel	_	_	_	_	_	_	_	_
127	knowledge	_	_	_	_	_	_	_	_
128	into	_	_	_	_	_	_	_	_
129	epidemiology	_	_	_	_	_	_	_	_
130	of	_	_	_	_	_	_	_	_
131	PEDV	_	_	_	_	_	_	_	_
132	infection	_	_	_	_	_	_	_	_
133	.	_	_	_	_	_	_	_	_

# newdoc_id = 1735d918984252bfb2ef6e6615c9f1b5d8cebac6
1	Poly(A	_	_	_	_	_	_	_	BeginSeg=Yes
2	)	_	_	_	_	_	_	_	_
3	tails	_	_	_	_	_	_	_	_
4	are	_	_	_	_	_	_	_	_
5	functionally	_	_	_	_	_	_	_	_
6	important	_	_	_	_	_	_	_	_
7	features	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	_
9	all	_	_	_	_	_	_	_	_
10	picornavirus	_	_	_	_	_	_	_	_
11	RNA	_	_	_	_	_	_	_	_
12	genomes	_	_	_	_	_	_	_	_
13	.	_	_	_	_	_	_	_	_
14	Some	_	_	_	_	_	_	_	BeginSeg=Yes
15	viruses	_	_	_	_	_	_	_	_
16	have	_	_	_	_	_	_	_	_
17	genomes	_	_	_	_	_	_	_	_
18	with	_	_	_	_	_	_	_	_
19	relatively	_	_	_	_	_	_	_	_
20	short	_	_	_	_	_	_	_	_
21	poly(A	_	_	_	_	_	_	_	_
22	)	_	_	_	_	_	_	_	_
23	tails	_	_	_	_	_	_	_	_
24	(	_	_	_	_	_	_	_	BeginSeg=Yes
25	encephalomyocarditis	_	_	_	_	_	_	_	_
26	virus	_	_	_	_	_	_	_	_
27	)	_	_	_	_	_	_	_	_
28	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
29	others	_	_	_	_	_	_	_	_
30	have	_	_	_	_	_	_	_	_
31	genomes	_	_	_	_	_	_	_	_
32	with	_	_	_	_	_	_	_	_
33	longer	_	_	_	_	_	_	_	_
34	poly(A	_	_	_	_	_	_	_	_
35	)	_	_	_	_	_	_	_	_
36	tails	_	_	_	_	_	_	_	_
37	(	_	_	_	_	_	_	_	BeginSeg=Yes
38	polioviruses	_	_	_	_	_	_	_	_
39	and	_	_	_	_	_	_	_	_
40	rhinoviruses	_	_	_	_	_	_	_	_
41	)	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
43	Here	_	_	_	_	_	_	_	BeginSeg=Yes
44	we	_	_	_	_	_	_	_	_
45	review	_	_	_	_	_	_	_	_
46	the	_	_	_	_	_	_	_	_
47	polyadenylation	_	_	_	_	_	_	_	_
48	of	_	_	_	_	_	_	_	_
49	picornavirus	_	_	_	_	_	_	_	_
50	RNA	_	_	_	_	_	_	_	_
51	as	_	_	_	_	_	_	_	BeginSeg=Yes
52	it	_	_	_	_	_	_	_	_
53	relates	_	_	_	_	_	_	_	_
54	to	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	structure	_	_	_	_	_	_	_	_
57	and	_	_	_	_	_	_	_	_
58	function	_	_	_	_	_	_	_	_
59	of	_	_	_	_	_	_	_	_
60	3D	_	_	_	_	_	_	_	_
61	pol	_	_	_	_	_	_	_	_
62	.	_	_	_	_	_	_	_	_
63	Poliovirus	_	_	_	_	_	_	_	BeginSeg=Yes
64	3D	_	_	_	_	_	_	_	_
65	pol	_	_	_	_	_	_	_	_
66	uses	_	_	_	_	_	_	_	_
67	template	_	_	_	_	_	_	_	_
68	-	_	_	_	_	_	_	_	_
69	dependent	_	_	_	_	_	_	_	_
70	reiterative	_	_	_	_	_	_	_	_
71	transcription	_	_	_	_	_	_	_	_
72	mechanisms	_	_	_	_	_	_	_	_
73	as	_	_	_	_	_	_	_	BeginSeg=Yes
74	it	_	_	_	_	_	_	_	_
75	replicates	_	_	_	_	_	_	_	_
76	the	_	_	_	_	_	_	_	_
77	poly(A	_	_	_	_	_	_	_	_
78	)	_	_	_	_	_	_	_	_
79	tails	_	_	_	_	_	_	_	_
80	of	_	_	_	_	_	_	_	_
81	viral	_	_	_	_	_	_	_	_
82	RNA	_	_	_	_	_	_	_	_
83	(	_	_	_	_	_	_	_	_
84	Steil	_	_	_	_	_	_	_	_
85	et	_	_	_	_	_	_	_	_
86	al	_	_	_	_	_	_	_	_
87	.	_	_	_	_	_	_	_	_
88	,	_	_	_	_	_	_	_	_
89	2010	_	_	_	_	_	_	_	_
90	)	_	_	_	_	_	_	_	_
91	.	_	_	_	_	_	_	_	_
92	These	_	_	_	_	_	_	_	BeginSeg=Yes
93	mechanisms	_	_	_	_	_	_	_	_
94	are	_	_	_	_	_	_	_	_
95	analogous	_	_	_	_	_	_	_	_
96	to	_	_	_	_	_	_	_	_
97	those	_	_	_	_	_	_	_	_
98	involved	_	_	_	_	_	_	_	BeginSeg=Yes
99	in	_	_	_	_	_	_	_	_
100	the	_	_	_	_	_	_	_	_
101	polyadenylation	_	_	_	_	_	_	_	_
102	of	_	_	_	_	_	_	_	_
103	vesicular	_	_	_	_	_	_	_	_
104	stomatitis	_	_	_	_	_	_	_	_
105	virus	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	influenza	_	_	_	_	_	_	_	_
108	virus	_	_	_	_	_	_	_	_
109	mRNAs	_	_	_	_	_	_	_	_
110	.	_	_	_	_	_	_	_	_
111	3D	_	_	_	_	_	_	_	BeginSeg=Yes
112	pol	_	_	_	_	_	_	_	_
113	residues	_	_	_	_	_	_	_	_
114	intimately	_	_	_	_	_	_	_	BeginSeg=Yes
115	associated	_	_	_	_	_	_	_	_
116	with	_	_	_	_	_	_	_	_
117	viral	_	_	_	_	_	_	_	_
118	RNA	_	_	_	_	_	_	_	_
119	templates	_	_	_	_	_	_	_	_
120	and	_	_	_	_	_	_	_	_
121	products	_	_	_	_	_	_	_	_
122	regulate	_	_	_	_	_	_	_	BeginSeg=Yes
123	the	_	_	_	_	_	_	_	_
124	size	_	_	_	_	_	_	_	_
125	of	_	_	_	_	_	_	_	_
126	poly(A	_	_	_	_	_	_	_	_
127	)	_	_	_	_	_	_	_	_
128	tails	_	_	_	_	_	_	_	_
129	in	_	_	_	_	_	_	_	_
130	viral	_	_	_	_	_	_	_	_
131	RNA	_	_	_	_	_	_	_	_
132	(	_	_	_	_	_	_	_	_
133	Kempf	_	_	_	_	_	_	_	_
134	et	_	_	_	_	_	_	_	_
135	al	_	_	_	_	_	_	_	_
136	.	_	_	_	_	_	_	_	_
137	,	_	_	_	_	_	_	_	_
138	2013	_	_	_	_	_	_	_	_
139	)	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	Consistent	_	_	_	_	_	_	_	BeginSeg=Yes
142	with	_	_	_	_	_	_	_	_
143	their	_	_	_	_	_	_	_	_
144	ancient	_	_	_	_	_	_	_	_
145	evolutionary	_	_	_	_	_	_	_	_
146	origins	_	_	_	_	_	_	_	_
147	,	_	_	_	_	_	_	_	_
148	picornavirus	_	_	_	_	_	_	_	BeginSeg=Yes
149	3D	_	_	_	_	_	_	_	_
150	pol	_	_	_	_	_	_	_	_
151	and	_	_	_	_	_	_	_	_
152	telomerase	_	_	_	_	_	_	_	_
153	reverse	_	_	_	_	_	_	_	_
154	transcriptase	_	_	_	_	_	_	_	_
155	(	_	_	_	_	_	_	_	_
156	TERT	_	_	_	_	_	_	_	_
157	)	_	_	_	_	_	_	_	_
158	share	_	_	_	_	_	_	_	_
159	structural	_	_	_	_	_	_	_	_
160	and	_	_	_	_	_	_	_	_
161	functional	_	_	_	_	_	_	_	_
162	features	_	_	_	_	_	_	_	_
163	.	_	_	_	_	_	_	_	_
164	Structurally	_	_	_	_	_	_	_	BeginSeg=Yes
165	,	_	_	_	_	_	_	_	_
166	both	_	_	_	_	_	_	_	_
167	3D	_	_	_	_	_	_	_	_
168	pol	_	_	_	_	_	_	_	_
169	and	_	_	_	_	_	_	_	_
170	TERT	_	_	_	_	_	_	_	_
171	assume	_	_	_	_	_	_	_	_
172	a	_	_	_	_	_	_	_	_
173	"	_	_	_	_	_	_	_	_
174	right	_	_	_	_	_	_	_	_
175	-	_	_	_	_	_	_	_	_
176	hand	_	_	_	_	_	_	_	_
177	"	_	_	_	_	_	_	_	_
178	conformation	_	_	_	_	_	_	_	_
179	with	_	_	_	_	_	_	_	_
180	thumb	_	_	_	_	_	_	_	_
181	,	_	_	_	_	_	_	_	_
182	palm	_	_	_	_	_	_	_	_
183	and	_	_	_	_	_	_	_	_
184	fingers	_	_	_	_	_	_	_	_
185	domains	_	_	_	_	_	_	_	_
186	encircling	_	_	_	_	_	_	_	BeginSeg=Yes
187	templates	_	_	_	_	_	_	_	_
188	and	_	_	_	_	_	_	_	_
189	products	_	_	_	_	_	_	_	_
190	.	_	_	_	_	_	_	_	_
191	Functionally	_	_	_	_	_	_	_	BeginSeg=Yes
192	,	_	_	_	_	_	_	_	_
193	both	_	_	_	_	_	_	_	_
194	3D	_	_	_	_	_	_	_	_
195	pol	_	_	_	_	_	_	_	_
196	and	_	_	_	_	_	_	_	_
197	TERT	_	_	_	_	_	_	_	_
198	use	_	_	_	_	_	_	_	_
199	template	_	_	_	_	_	_	_	_
200	-	_	_	_	_	_	_	_	_
201	dependent	_	_	_	_	_	_	_	_
202	reiterative	_	_	_	_	_	_	_	_
203	transcription	_	_	_	_	_	_	_	_
204	mechanisms	_	_	_	_	_	_	_	_
205	to	_	_	_	_	_	_	_	BeginSeg=Yes
206	synthesize	_	_	_	_	_	_	_	_
207	repetitive	_	_	_	_	_	_	_	_
208	sequences	_	_	_	_	_	_	_	_
209	:	_	_	_	_	_	_	_	_
210	poly(A	_	_	_	_	_	_	_	BeginSeg=Yes
211	)	_	_	_	_	_	_	_	_
212	tails	_	_	_	_	_	_	_	_
213	in	_	_	_	_	_	_	_	_
214	the	_	_	_	_	_	_	_	_
215	case	_	_	_	_	_	_	_	_
216	of	_	_	_	_	_	_	_	_
217	picornavirus	_	_	_	_	_	_	_	_
218	RNA	_	_	_	_	_	_	_	_
219	genomes	_	_	_	_	_	_	_	_
220	and	_	_	_	_	_	_	_	_
221	DNA	_	_	_	_	_	_	_	_
222	telomeres	_	_	_	_	_	_	_	_
223	in	_	_	_	_	_	_	_	_
224	the	_	_	_	_	_	_	_	_
225	case	_	_	_	_	_	_	_	_
226	of	_	_	_	_	_	_	_	_
227	eukaryotic	_	_	_	_	_	_	_	_
228	chromosomes	_	_	_	_	_	_	_	_
229	.	_	_	_	_	_	_	_	_
230	Thus	_	_	_	_	_	_	_	BeginSeg=Yes
231	,	_	_	_	_	_	_	_	_
232	picornaviruses	_	_	_	_	_	_	_	_
233	and	_	_	_	_	_	_	_	_
234	their	_	_	_	_	_	_	_	_
235	eukaryotic	_	_	_	_	_	_	_	_
236	hosts	_	_	_	_	_	_	_	_
237	(	_	_	_	_	_	_	_	BeginSeg=Yes
238	humans	_	_	_	_	_	_	_	_
239	and	_	_	_	_	_	_	_	_
240	animals	_	_	_	_	_	_	_	_
241	)	_	_	_	_	_	_	_	_
242	maintain	_	_	_	_	_	_	_	BeginSeg=Yes
243	the	_	_	_	_	_	_	_	_
244	3	_	_	_	_	_	_	_	_
245	ends	_	_	_	_	_	_	_	_
246	of	_	_	_	_	_	_	_	_
247	their	_	_	_	_	_	_	_	_
248	respective	_	_	_	_	_	_	_	_
249	genomes	_	_	_	_	_	_	_	_
250	via	_	_	_	_	_	_	_	_
251	evolutionarily	_	_	_	_	_	_	_	_
252	related	_	_	_	_	_	_	_	_
253	mechanisms	_	_	_	_	_	_	_	_
254	.	_	_	_	_	_	_	_	_

# newdoc_id = 180a37cecacf1df23085e9dc702d07342c9c0ce2
1	We	_	_	_	_	_	_	_	BeginSeg=Yes
2	present	_	_	_	_	_	_	_	_
3	an	_	_	_	_	_	_	_	_
4	epidemic	_	_	_	_	_	_	_	_
5	model	_	_	_	_	_	_	_	_
6	capable	_	_	_	_	_	_	_	_
7	of	_	_	_	_	_	_	_	_
8	describing	_	_	_	_	_	_	_	_
9	key	_	_	_	_	_	_	_	_
10	features	_	_	_	_	_	_	_	_
11	of	_	_	_	_	_	_	_	_
12	the	_	_	_	_	_	_	_	_
13	present	_	_	_	_	_	_	_	_
14	Covid-19	_	_	_	_	_	_	_	_
15	pandemic	_	_	_	_	_	_	_	_
16	.	_	_	_	_	_	_	_	_
17	While	_	_	_	_	_	_	_	BeginSeg=Yes
18	capturing	_	_	_	_	_	_	_	_
19	several	_	_	_	_	_	_	_	_
20	qualitative	_	_	_	_	_	_	_	_
21	properties	_	_	_	_	_	_	_	_
22	of	_	_	_	_	_	_	_	_
23	the	_	_	_	_	_	_	_	_
24	virus	_	_	_	_	_	_	_	_
25	spreading	_	_	_	_	_	_	_	_
26	,	_	_	_	_	_	_	_	_
27	it	_	_	_	_	_	_	_	BeginSeg=Yes
28	allows	_	_	_	_	_	_	_	_
29	to	_	_	_	_	_	_	_	_
30	compute	_	_	_	_	_	_	_	_
31	the	_	_	_	_	_	_	_	_
32	basic	_	_	_	_	_	_	_	_
33	reproduction	_	_	_	_	_	_	_	_
34	number	_	_	_	_	_	_	_	_
35	,	_	_	_	_	_	_	_	_
36	the	_	_	_	_	_	_	_	_
37	number	_	_	_	_	_	_	_	_
38	of	_	_	_	_	_	_	_	_
39	deaths	_	_	_	_	_	_	_	_
40	due	_	_	_	_	_	_	_	_
41	to	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
43	virus	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	_
45	various	_	_	_	_	_	_	_	_
46	other	_	_	_	_	_	_	_	_
47	statistics	_	_	_	_	_	_	_	_
48	.	_	_	_	_	_	_	_	_
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50	integrations	_	_	_	_	_	_	_	_
51	are	_	_	_	_	_	_	_	_
52	used	_	_	_	_	_	_	_	_
53	to	_	_	_	_	_	_	_	BeginSeg=Yes
54	illustrate	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	relevance	_	_	_	_	_	_	_	_
57	of	_	_	_	_	_	_	_	_
58	quarantine	_	_	_	_	_	_	_	_
59	and	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	role	_	_	_	_	_	_	_	_
62	of	_	_	_	_	_	_	_	_
63	care	_	_	_	_	_	_	_	_
64	houses	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_

# newdoc_id = 1b154ff0f22d4ac97b61cc3fbc65a21020010468
1	Air	_	_	_	_	_	_	_	BeginSeg=Yes
2	pollution	_	_	_	_	_	_	_	_
3	is	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	most	_	_	_	_	_	_	_	_
6	significant	_	_	_	_	_	_	_	_
7	environmental	_	_	_	_	_	_	_	_
8	risk	_	_	_	_	_	_	_	_
9	factor	_	_	_	_	_	_	_	_
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11	all	_	_	_	_	_	_	_	_
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13	cause	_	_	_	_	_	_	_	_
14	mortality	_	_	_	_	_	_	_	_
15	,	_	_	_	_	_	_	_	_
16	and	_	_	_	_	_	_	_	BeginSeg=Yes
17	it	_	_	_	_	_	_	_	_
18	has	_	_	_	_	_	_	_	_
19	caused	_	_	_	_	_	_	_	_
20	substantial	_	_	_	_	_	_	_	_
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26	years	_	_	_	_	_	_	_	_
27	and	_	_	_	_	_	_	_	_
28	economic	_	_	_	_	_	_	_	_
29	loss	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	Air	_	_	_	_	_	_	_	BeginSeg=Yes
32	pollution	_	_	_	_	_	_	_	_
33	intensified	_	_	_	_	_	_	_	_
34	the	_	_	_	_	_	_	_	_
35	mortality	_	_	_	_	_	_	_	_
36	during	_	_	_	_	_	_	_	_
37	past	_	_	_	_	_	_	_	_
38	pandemics	_	_	_	_	_	_	_	_
39	,	_	_	_	_	_	_	_	_
40	Spanish	_	_	_	_	_	_	_	_
41	flu	_	_	_	_	_	_	_	_
42	in	_	_	_	_	_	_	_	_
43	1918	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	_
45	SARS	_	_	_	_	_	_	_	_
46	-	_	_	_	_	_	_	_	_
47	CoV-1	_	_	_	_	_	_	_	_
48	in	_	_	_	_	_	_	_	_
49	2003	_	_	_	_	_	_	_	_
50	.	_	_	_	_	_	_	_	_
51	It	_	_	_	_	_	_	_	BeginSeg=Yes
52	increases	_	_	_	_	_	_	_	_
53	host	_	_	_	_	_	_	_	_
54	susceptibility	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	_
56	virulence	_	_	_	_	_	_	_	_
57	of	_	_	_	_	_	_	_	_
58	respiratory	_	_	_	_	_	_	_	_
59	infections	_	_	_	_	_	_	_	_
60	and	_	_	_	_	_	_	_	BeginSeg=Yes
61	reduces	_	_	_	_	_	_	_	_
62	viral	_	_	_	_	_	_	_	_
63	clearance	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
65	Thus	_	_	_	_	_	_	_	BeginSeg=Yes
66	,	_	_	_	_	_	_	_	_
67	a	_	_	_	_	_	_	_	_
68	question	_	_	_	_	_	_	_	_
69	arises	_	_	_	_	_	_	_	_
70	whether	_	_	_	_	_	_	_	_
71	there	_	_	_	_	_	_	_	_
72	will	_	_	_	_	_	_	_	_
73	be	_	_	_	_	_	_	_	_
74	any	_	_	_	_	_	_	_	_
75	impact	_	_	_	_	_	_	_	_
76	of	_	_	_	_	_	_	_	_
77	air	_	_	_	_	_	_	_	_
78	pollution	_	_	_	_	_	_	_	_
79	on	_	_	_	_	_	_	_	_
80	the	_	_	_	_	_	_	_	_
81	current	_	_	_	_	_	_	_	_
82	pandemic	_	_	_	_	_	_	_	_
83	coronavirus	_	_	_	_	_	_	_	_
84	disease	_	_	_	_	_	_	_	_
85	2019	_	_	_	_	_	_	_	_
86	(	_	_	_	_	_	_	_	_
87	COVID-19	_	_	_	_	_	_	_	_
88	)	_	_	_	_	_	_	_	_
89	?	_	_	_	_	_	_	_	_
90	Thus	_	_	_	_	_	_	_	BeginSeg=Yes
91	far	_	_	_	_	_	_	_	_
92	,	_	_	_	_	_	_	_	_
93	history	_	_	_	_	_	_	_	_
94	and	_	_	_	_	_	_	_	_
95	science	_	_	_	_	_	_	_	_
96	are	_	_	_	_	_	_	_	_
97	directing	_	_	_	_	_	_	_	_
98	towards	_	_	_	_	_	_	_	_
99	an	_	_	_	_	_	_	_	_
100	immense	_	_	_	_	_	_	_	_
101	potential	_	_	_	_	_	_	_	_
102	impact	_	_	_	_	_	_	_	_
103	of	_	_	_	_	_	_	_	_
104	air	_	_	_	_	_	_	_	_
105	pollution	_	_	_	_	_	_	_	_
106	on	_	_	_	_	_	_	_	_
107	the	_	_	_	_	_	_	_	_
108	COVID-19	_	_	_	_	_	_	_	_
109	pandemic	_	_	_	_	_	_	_	_
110	.	_	_	_	_	_	_	_	_
111	Some	_	_	_	_	_	_	_	BeginSeg=Yes
112	of	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	devastated	_	_	_	_	_	_	_	_
115	countries	_	_	_	_	_	_	_	_
116	with	_	_	_	_	_	_	_	_
117	the	_	_	_	_	_	_	_	_
118	current	_	_	_	_	_	_	_	_
119	pandemic	_	_	_	_	_	_	_	_
120	are	_	_	_	_	_	_	_	_
121	those	_	_	_	_	_	_	_	_
122	with	_	_	_	_	_	_	_	_
123	a	_	_	_	_	_	_	_	_
124	poor	_	_	_	_	_	_	_	_
125	air	_	_	_	_	_	_	_	_
126	quality	_	_	_	_	_	_	_	_
127	index	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	Further	_	_	_	_	_	_	_	BeginSeg=Yes
130	epidemiological	_	_	_	_	_	_	_	_
131	and	_	_	_	_	_	_	_	_
132	ecological	_	_	_	_	_	_	_	_
133	studies	_	_	_	_	_	_	_	_
134	are	_	_	_	_	_	_	_	_
135	necessary	_	_	_	_	_	_	_	_
136	to	_	_	_	_	_	_	_	BeginSeg=Yes
137	confirm	_	_	_	_	_	_	_	_
138	this	_	_	_	_	_	_	_	_
139	association	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	Also	_	_	_	_	_	_	_	BeginSeg=Yes
142	,	_	_	_	_	_	_	_	_
143	countries	_	_	_	_	_	_	_	_
144	must	_	_	_	_	_	_	_	_
145	mobilize	_	_	_	_	_	_	_	_
146	funding	_	_	_	_	_	_	_	_
147	for	_	_	_	_	_	_	_	_
148	mitigation	_	_	_	_	_	_	_	_
149	of	_	_	_	_	_	_	_	_
150	air	_	_	_	_	_	_	_	_
151	pollution	_	_	_	_	_	_	_	_
152	to	_	_	_	_	_	_	_	BeginSeg=Yes
153	benefit	_	_	_	_	_	_	_	_
154	environmental	_	_	_	_	_	_	_	_
155	health	_	_	_	_	_	_	_	_
156	and	_	_	_	_	_	_	_	BeginSeg=Yes
157	ameliorate	_	_	_	_	_	_	_	_
158	its	_	_	_	_	_	_	_	_
159	potential	_	_	_	_	_	_	_	_
160	effects	_	_	_	_	_	_	_	_
161	on	_	_	_	_	_	_	_	_
162	pandemics	_	_	_	_	_	_	_	_
163	of	_	_	_	_	_	_	_	_
164	the	_	_	_	_	_	_	_	_
165	future	_	_	_	_	_	_	_	_
166	.	_	_	_	_	_	_	_	_

# newdoc_id = 1b8a085682d10dad4baf90417a8cbcde144cc8c9
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	evaluation	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	infectious	_	_	_	_	_	_	_	_
5	and	_	_	_	_	_	_	_	_
6	noninfectious	_	_	_	_	_	_	_	_
7	disease	_	_	_	_	_	_	_	_
8	management	_	_	_	_	_	_	_	_
9	can	_	_	_	_	_	_	_	_
10	be	_	_	_	_	_	_	_	_
11	done	_	_	_	_	_	_	_	_
12	through	_	_	_	_	_	_	_	_
13	the	_	_	_	_	_	_	_	_
14	use	_	_	_	_	_	_	_	_
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16	a	_	_	_	_	_	_	_	_
17	time	_	_	_	_	_	_	_	_
18	series	_	_	_	_	_	_	_	_
19	analysis	_	_	_	_	_	_	_	_
20	.	_	_	_	_	_	_	_	_
21	In	_	_	_	_	_	_	_	BeginSeg=Yes
22	this	_	_	_	_	_	_	_	_
23	study	_	_	_	_	_	_	_	_
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25	we	_	_	_	_	_	_	_	_
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27	to	_	_	_	_	_	_	_	_
28	measure	_	_	_	_	_	_	_	_
29	the	_	_	_	_	_	_	_	_
30	results	_	_	_	_	_	_	_	_
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32	prevent	_	_	_	_	_	_	_	_
33	intervention	_	_	_	_	_	_	_	_
34	effects	_	_	_	_	_	_	_	_
35	on	_	_	_	_	_	_	_	_
36	the	_	_	_	_	_	_	_	_
37	disease	_	_	_	_	_	_	_	_
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39	Clinical	_	_	_	_	_	_	_	BeginSeg=Yes
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48	techniques	_	_	_	_	_	_	_	_
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71	.	_	_	_	_	_	_	_	_
72	This	_	_	_	_	_	_	_	BeginSeg=Yes
73	analytical	_	_	_	_	_	_	_	_
74	tool	_	_	_	_	_	_	_	_
75	offers	_	_	_	_	_	_	_	_
76	a	_	_	_	_	_	_	_	_
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78	contribution	_	_	_	_	_	_	_	_
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80	researchers	_	_	_	_	_	_	_	_
81	and	_	_	_	_	_	_	_	_
82	healthcare	_	_	_	_	_	_	_	_
83	managers	_	_	_	_	_	_	_	_
84	in	_	_	_	_	_	_	_	_
85	the	_	_	_	_	_	_	_	_
86	evaluation	_	_	_	_	_	_	_	_
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88	healthcare	_	_	_	_	_	_	_	_
89	interventions	_	_	_	_	_	_	_	_
90	in	_	_	_	_	_	_	_	_
91	specific	_	_	_	_	_	_	_	_
92	populations	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_

# newdoc_id = 1be50b82b258db680534fd344a0da386ee461361
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2	viral	_	_	_	_	_	_	_	_
3	adaptation	_	_	_	_	_	_	_	_
4	is	_	_	_	_	_	_	_	_
5	a	_	_	_	_	_	_	_	_
6	powerful	_	_	_	_	_	_	_	_
7	technique	_	_	_	_	_	_	_	_
8	employed	_	_	_	_	_	_	_	BeginSeg=Yes
9	to	_	_	_	_	_	_	_	BeginSeg=Yes
10	study	_	_	_	_	_	_	_	_
11	the	_	_	_	_	_	_	_	_
12	ways	_	_	_	_	_	_	_	_
13	viruses	_	_	_	_	_	_	_	BeginSeg=Yes
14	may	_	_	_	_	_	_	_	_
15	overcome	_	_	_	_	_	_	_	_
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18	pressures	_	_	_	_	_	_	_	_
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20	reduce	_	_	_	_	_	_	_	_
21	viral	_	_	_	_	_	_	_	_
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23	.	_	_	_	_	_	_	_	_
24	Here	_	_	_	_	_	_	_	BeginSeg=Yes
25	,	_	_	_	_	_	_	_	_
26	we	_	_	_	_	_	_	_	_
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28	methods	_	_	_	_	_	_	_	_
29	for	_	_	_	_	_	_	_	_
30	in	_	_	_	_	_	_	_	_
31	vitro	_	_	_	_	_	_	_	_
32	serial	_	_	_	_	_	_	_	_
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34	of	_	_	_	_	_	_	_	_
35	Middle	_	_	_	_	_	_	_	_
36	East	_	_	_	_	_	_	_	_
37	respiratory	_	_	_	_	_	_	_	_
38	syndrome	_	_	_	_	_	_	_	_
39	coronavirus	_	_	_	_	_	_	_	_
40	(	_	_	_	_	_	_	_	_
41	MERS	_	_	_	_	_	_	_	_
42	-	_	_	_	_	_	_	_	_
43	CoV	_	_	_	_	_	_	_	_
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45	to	_	_	_	_	_	_	_	BeginSeg=Yes
46	select	_	_	_	_	_	_	_	_
47	for	_	_	_	_	_	_	_	_
48	mutations	_	_	_	_	_	_	_	_
49	which	_	_	_	_	_	_	_	BeginSeg=Yes
50	increase	_	_	_	_	_	_	_	_
51	replication	_	_	_	_	_	_	_	_
52	on	_	_	_	_	_	_	_	_
53	semi	_	_	_	_	_	_	_	_
54	-	_	_	_	_	_	_	_	_
55	permissive	_	_	_	_	_	_	_	_
56	cell	_	_	_	_	_	_	_	_
57	lines	_	_	_	_	_	_	_	_
58	as	_	_	_	_	_	_	_	BeginSeg=Yes
59	described	_	_	_	_	_	_	_	_
60	in	_	_	_	_	_	_	_	_
61	Letko	_	_	_	_	_	_	_	_
62	et	_	_	_	_	_	_	_	_
63	al	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
65	,	_	_	_	_	_	_	_	_
66	Cell	_	_	_	_	_	_	_	_
67	Rep	_	_	_	_	_	_	_	_
68	24	_	_	_	_	_	_	_	_
69	,	_	_	_	_	_	_	_	_
70	1730	_	_	_	_	_	_	_	_
71	-	_	_	_	_	_	_	_	_
72	1737	_	_	_	_	_	_	_	_
73	,	_	_	_	_	_	_	_	_
74	2018	_	_	_	_	_	_	_	_

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1	Compared	_	_	_	_	_	_	_	BeginSeg=Yes
2	with	_	_	_	_	_	_	_	_
3	temperate	_	_	_	_	_	_	_	_
4	areas	_	_	_	_	_	_	_	_
5	,	_	_	_	_	_	_	_	_
6	the	_	_	_	_	_	_	_	BeginSeg=Yes
7	understanding	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	_
9	seasonal	_	_	_	_	_	_	_	_
10	variations	_	_	_	_	_	_	_	_
11	of	_	_	_	_	_	_	_	_
12	influenza	_	_	_	_	_	_	_	_
13	infections	_	_	_	_	_	_	_	_
14	is	_	_	_	_	_	_	_	_
15	lacking	_	_	_	_	_	_	_	_
16	in	_	_	_	_	_	_	_	_
17	subtropical	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	_
19	tropical	_	_	_	_	_	_	_	_
20	regions	_	_	_	_	_	_	_	_
21	.	_	_	_	_	_	_	_	_
22	Insufficient	_	_	_	_	_	_	_	BeginSeg=Yes
23	information	_	_	_	_	_	_	_	_
24	about	_	_	_	_	_	_	_	_
25	viral	_	_	_	_	_	_	_	_
26	activity	_	_	_	_	_	_	_	_
27	increases	_	_	_	_	_	_	_	_
28	the	_	_	_	_	_	_	_	_
29	difficulty	_	_	_	_	_	_	_	_
30	of	_	_	_	_	_	_	_	BeginSeg=Yes
31	forecasting	_	_	_	_	_	_	_	_
32	the	_	_	_	_	_	_	_	_
33	disease	_	_	_	_	_	_	_	_
34	burden	_	_	_	_	_	_	_	_
35	and	_	_	_	_	_	_	_	BeginSeg=Yes
36	thus	_	_	_	_	_	_	_	_
37	hampers	_	_	_	_	_	_	_	_
38	official	_	_	_	_	_	_	_	_
39	preparation	_	_	_	_	_	_	_	_
40	efforts	_	_	_	_	_	_	_	_
41	.	_	_	_	_	_	_	_	_
42	Here	_	_	_	_	_	_	_	BeginSeg=Yes
43	we	_	_	_	_	_	_	_	_
44	identified	_	_	_	_	_	_	_	_
45	potential	_	_	_	_	_	_	_	_
46	meteorological	_	_	_	_	_	_	_	_
47	factors	_	_	_	_	_	_	_	_
48	that	_	_	_	_	_	_	_	BeginSeg=Yes
49	drove	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	seasonal	_	_	_	_	_	_	_	_
52	variations	_	_	_	_	_	_	_	_
53	in	_	_	_	_	_	_	_	_
54	influenza	_	_	_	_	_	_	_	_
55	infections	_	_	_	_	_	_	_	_
56	in	_	_	_	_	_	_	_	_
57	a	_	_	_	_	_	_	_	_
58	subtropical	_	_	_	_	_	_	_	_
59	city	_	_	_	_	_	_	_	_
60	,	_	_	_	_	_	_	_	_
61	Hong	_	_	_	_	_	_	_	_
62	Kong	_	_	_	_	_	_	_	_
63	.	_	_	_	_	_	_	_	_
64	We	_	_	_	_	_	_	_	BeginSeg=Yes
65	fitted	_	_	_	_	_	_	_	_
66	the	_	_	_	_	_	_	_	_
67	meteorological	_	_	_	_	_	_	_	_
68	data	_	_	_	_	_	_	_	_
69	and	_	_	_	_	_	_	_	_
70	influenza	_	_	_	_	_	_	_	_
71	mortality	_	_	_	_	_	_	_	_
72	data	_	_	_	_	_	_	_	_
73	from	_	_	_	_	_	_	_	_
74	2002	_	_	_	_	_	_	_	_
75	to	_	_	_	_	_	_	_	_
76	2009	_	_	_	_	_	_	_	_
77	in	_	_	_	_	_	_	_	_
78	a	_	_	_	_	_	_	_	_
79	Susceptible	_	_	_	_	_	_	_	_
80	-	_	_	_	_	_	_	_	_
81	Infected	_	_	_	_	_	_	_	_
82	-	_	_	_	_	_	_	_	_
83	Recovered	_	_	_	_	_	_	_	_
84	model	_	_	_	_	_	_	_	_
85	.	_	_	_	_	_	_	_	_
86	From	_	_	_	_	_	_	_	BeginSeg=Yes
87	the	_	_	_	_	_	_	_	_
88	results	_	_	_	_	_	_	_	_
89	,	_	_	_	_	_	_	_	_
90	air	_	_	_	_	_	_	_	_
91	temperature	_	_	_	_	_	_	_	_
92	was	_	_	_	_	_	_	_	_
93	a	_	_	_	_	_	_	_	_
94	common	_	_	_	_	_	_	_	_
95	significant	_	_	_	_	_	_	_	_
96	driver	_	_	_	_	_	_	_	_
97	of	_	_	_	_	_	_	_	_
98	seasonal	_	_	_	_	_	_	_	_
99	patterns	_	_	_	_	_	_	_	_
100	and	_	_	_	_	_	_	_	BeginSeg=Yes
101	cold	_	_	_	_	_	_	_	_
102	temperature	_	_	_	_	_	_	_	_
103	was	_	_	_	_	_	_	_	_
104	associated	_	_	_	_	_	_	_	_
105	with	_	_	_	_	_	_	_	_
106	an	_	_	_	_	_	_	_	_
107	increase	_	_	_	_	_	_	_	_
108	in	_	_	_	_	_	_	_	_
109	transmission	_	_	_	_	_	_	_	_
110	intensity	_	_	_	_	_	_	_	_
111	for	_	_	_	_	_	_	_	_
112	most	_	_	_	_	_	_	_	_
113	of	_	_	_	_	_	_	_	_
114	the	_	_	_	_	_	_	_	_
115	influenza	_	_	_	_	_	_	_	_
116	epidemics	_	_	_	_	_	_	_	_
117	.	_	_	_	_	_	_	_	_
118	Except	_	_	_	_	_	_	_	BeginSeg=Yes
119	2004	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	the	_	_	_	_	_	_	_	_
122	fitted	_	_	_	_	_	_	_	_
123	models	_	_	_	_	_	_	_	_
124	with	_	_	_	_	_	_	_	_
125	significant	_	_	_	_	_	_	_	_
126	meteorological	_	_	_	_	_	_	_	_
127	factors	_	_	_	_	_	_	_	_
128	could	_	_	_	_	_	_	_	_
129	account	_	_	_	_	_	_	_	_
130	for	_	_	_	_	_	_	_	_
131	more	_	_	_	_	_	_	_	_
132	than	_	_	_	_	_	_	_	_
133	10	_	_	_	_	_	_	_	_
134	%	_	_	_	_	_	_	_	_
135	of	_	_	_	_	_	_	_	_
136	the	_	_	_	_	_	_	_	_
137	variance	_	_	_	_	_	_	_	_
138	in	_	_	_	_	_	_	_	_
139	additional	_	_	_	_	_	_	_	_
140	to	_	_	_	_	_	_	_	_
141	the	_	_	_	_	_	_	_	_
142	null	_	_	_	_	_	_	_	_
143	model	_	_	_	_	_	_	_	_
144	.	_	_	_	_	_	_	_	_
145	Rainfall	_	_	_	_	_	_	_	BeginSeg=Yes
146	was	_	_	_	_	_	_	_	_
147	also	_	_	_	_	_	_	_	_
148	found	_	_	_	_	_	_	_	_
149	to	_	_	_	_	_	_	_	_
150	be	_	_	_	_	_	_	_	_
151	a	_	_	_	_	_	_	_	_
152	significant	_	_	_	_	_	_	_	_
153	driver	_	_	_	_	_	_	_	_
154	of	_	_	_	_	_	_	_	_
155	seasonal	_	_	_	_	_	_	_	_
156	influenza	_	_	_	_	_	_	_	_
157	,	_	_	_	_	_	_	_	_
158	although	_	_	_	_	_	_	_	BeginSeg=Yes
159	results	_	_	_	_	_	_	_	_
160	were	_	_	_	_	_	_	_	_
161	less	_	_	_	_	_	_	_	_
162	robust	_	_	_	_	_	_	_	_
163	.	_	_	_	_	_	_	_	_
164	The	_	_	_	_	_	_	_	BeginSeg=Yes
165	identified	_	_	_	_	_	_	_	_
166	meteorological	_	_	_	_	_	_	_	_
167	indicators	_	_	_	_	_	_	_	_
168	could	_	_	_	_	_	_	_	_
169	alert	_	_	_	_	_	_	_	_
170	officials	_	_	_	_	_	_	_	_
171	to	_	_	_	_	_	_	_	_
172	take	_	_	_	_	_	_	_	_
173	appropriate	_	_	_	_	_	_	_	_
174	control	_	_	_	_	_	_	_	_
175	measures	_	_	_	_	_	_	_	_
176	for	_	_	_	_	_	_	_	_
177	influenza	_	_	_	_	_	_	_	_
178	epidemics	_	_	_	_	_	_	_	_
179	,	_	_	_	_	_	_	_	_
180	such	_	_	_	_	_	_	_	BeginSeg=Yes
181	as	_	_	_	_	_	_	_	_
182	enhancing	_	_	_	_	_	_	_	_
183	vaccination	_	_	_	_	_	_	_	_
184	activities	_	_	_	_	_	_	_	_
185	before	_	_	_	_	_	_	_	_
186	cold	_	_	_	_	_	_	_	_
187	seasons	_	_	_	_	_	_	_	_
188	.	_	_	_	_	_	_	_	_
189	Further	_	_	_	_	_	_	_	BeginSeg=Yes
190	studies	_	_	_	_	_	_	_	_
191	are	_	_	_	_	_	_	_	_
192	required	_	_	_	_	_	_	_	_
193	to	_	_	_	_	_	_	_	BeginSeg=Yes
194	fully	_	_	_	_	_	_	_	_
195	justify	_	_	_	_	_	_	_	_
196	the	_	_	_	_	_	_	_	_
197	associations	_	_	_	_	_	_	_	_
198	.	_	_	_	_	_	_	_	_

# newdoc_id = 1ea8699c1a259ed2a4c0d1c70e1c842eac6c2063
1	Avian	_	_	_	_	_	_	_	BeginSeg=Yes
2	metapneumovirus	_	_	_	_	_	_	_	_
3	(	_	_	_	_	_	_	_	_
4	aMPV	_	_	_	_	_	_	_	_
5	)	_	_	_	_	_	_	_	_
6	is	_	_	_	_	_	_	_	_
7	one	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	major	_	_	_	_	_	_	_	_
11	causes	_	_	_	_	_	_	_	_
12	of	_	_	_	_	_	_	_	_
13	serious	_	_	_	_	_	_	_	_
14	respiratory	_	_	_	_	_	_	_	_
15	infections	_	_	_	_	_	_	_	_
16	of	_	_	_	_	_	_	_	_
17	poultry	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	BeginSeg=Yes
19	leads	_	_	_	_	_	_	_	_
20	to	_	_	_	_	_	_	_	_
21	considerable	_	_	_	_	_	_	_	_
22	economic	_	_	_	_	_	_	_	_
23	losses	_	_	_	_	_	_	_	_
24	to	_	_	_	_	_	_	_	_
25	food	_	_	_	_	_	_	_	_
26	animal	_	_	_	_	_	_	_	_
27	production	_	_	_	_	_	_	_	_
28	worldwide	_	_	_	_	_	_	_	_
29	.	_	_	_	_	_	_	_	_
30	Here	_	_	_	_	_	_	_	BeginSeg=Yes
31	,	_	_	_	_	_	_	_	_
32	we	_	_	_	_	_	_	_	_
33	show	_	_	_	_	_	_	_	_
34	that	_	_	_	_	_	_	_	BeginSeg=Yes
35	double	_	_	_	_	_	_	_	_
36	stranded	_	_	_	_	_	_	_	_
37	short	_	_	_	_	_	_	_	_
38	interfering	_	_	_	_	_	_	_	_
39	RNA	_	_	_	_	_	_	_	_
40	(	_	_	_	_	_	_	_	_
41	siRNA	_	_	_	_	_	_	_	_
42	)	_	_	_	_	_	_	_	_
43	molecules	_	_	_	_	_	_	_	_
44	corresponding	_	_	_	_	_	_	_	BeginSeg=Yes
45	to	_	_	_	_	_	_	_	_
46	aMPV	_	_	_	_	_	_	_	_
47	phosphoprotein	_	_	_	_	_	_	_	_
48	(	_	_	_	_	_	_	_	_
49	P	_	_	_	_	_	_	_	_
50	)	_	_	_	_	_	_	_	_
51	gene	_	_	_	_	_	_	_	_
52	silence	_	_	_	_	_	_	_	BeginSeg=Yes
53	P	_	_	_	_	_	_	_	_
54	RNA	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	_
56	protein	_	_	_	_	_	_	_	_
57	expression	_	_	_	_	_	_	_	_
58	.	_	_	_	_	_	_	_	_
59	These	_	_	_	_	_	_	_	BeginSeg=Yes
60	siRNAs	_	_	_	_	_	_	_	_
61	broadly	_	_	_	_	_	_	_	_
62	reduced	_	_	_	_	_	_	_	_
63	the	_	_	_	_	_	_	_	_
64	expression	_	_	_	_	_	_	_	_
65	of	_	_	_	_	_	_	_	_
66	other	_	_	_	_	_	_	_	_
67	viral	_	_	_	_	_	_	_	_
68	proteins	_	_	_	_	_	_	_	_
69	in	_	_	_	_	_	_	_	_
70	addition	_	_	_	_	_	_	_	_
71	to	_	_	_	_	_	_	_	_
72	P	_	_	_	_	_	_	_	_
73	,	_	_	_	_	_	_	_	_
74	but	_	_	_	_	_	_	_	BeginSeg=Yes
75	did	_	_	_	_	_	_	_	_
76	not	_	_	_	_	_	_	_	_
77	have	_	_	_	_	_	_	_	_
78	a	_	_	_	_	_	_	_	_
79	discernable	_	_	_	_	_	_	_	_
80	effect	_	_	_	_	_	_	_	_
81	on	_	_	_	_	_	_	_	_
82	cellular	_	_	_	_	_	_	_	_
83	protein	_	_	_	_	_	_	_	_
84	expression	_	_	_	_	_	_	_	_
85	.	_	_	_	_	_	_	_	_
86	The	_	_	_	_	_	_	_	BeginSeg=Yes
87	exposure	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
89	cells	_	_	_	_	_	_	_	_
90	to	_	_	_	_	_	_	_	_
91	P	_	_	_	_	_	_	_	_
92	-	_	_	_	_	_	_	_	_
93	specific	_	_	_	_	_	_	_	_
94	siRNAs	_	_	_	_	_	_	_	_
95	also	_	_	_	_	_	_	_	_
96	led	_	_	_	_	_	_	_	_
97	to	_	_	_	_	_	_	_	_
98	inhibition	_	_	_	_	_	_	_	_
99	of	_	_	_	_	_	_	_	_
100	virus	_	_	_	_	_	_	_	_
101	replication	_	_	_	_	_	_	_	_
102	as	_	_	_	_	_	_	_	BeginSeg=Yes
103	evidenced	_	_	_	_	_	_	_	_
104	by	_	_	_	_	_	_	_	_
105	marked	_	_	_	_	_	_	_	_
106	reduction	_	_	_	_	_	_	_	_
107	in	_	_	_	_	_	_	_	_
108	the	_	_	_	_	_	_	_	_
109	progeny	_	_	_	_	_	_	_	_
110	virion	_	_	_	_	_	_	_	_
111	titers	_	_	_	_	_	_	_	_
112	.	_	_	_	_	_	_	_	_
113	Taken	_	_	_	_	_	_	_	BeginSeg=Yes
114	together	_	_	_	_	_	_	_	_
115	,	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	BeginSeg=Yes
117	findings	_	_	_	_	_	_	_	_
118	suggest	_	_	_	_	_	_	_	_
119	that	_	_	_	_	_	_	_	BeginSeg=Yes
120	exogenous	_	_	_	_	_	_	_	_
121	P	_	_	_	_	_	_	_	_
122	silencing	_	_	_	_	_	_	_	_
123	siRNAs	_	_	_	_	_	_	_	_
124	can	_	_	_	_	_	_	_	_
125	inhibit	_	_	_	_	_	_	_	_
126	aMPV	_	_	_	_	_	_	_	_
127	replication	_	_	_	_	_	_	_	_
128	with	_	_	_	_	_	_	_	_
129	potential	_	_	_	_	_	_	_	_
130	implications	_	_	_	_	_	_	_	_
131	in	_	_	_	_	_	_	_	_
132	the	_	_	_	_	_	_	_	_
133	design	_	_	_	_	_	_	_	_
134	of	_	_	_	_	_	_	_	_
135	novel	_	_	_	_	_	_	_	_
136	siRNA	_	_	_	_	_	_	_	_
137	based	_	_	_	_	_	_	_	_
138	prophylactics	_	_	_	_	_	_	_	_
139	.	_	_	_	_	_	_	_	_

# newdoc_id = 1f2bbc79b56c51c0ae26ced2d7d8ccf10360fa72
1	Ribonuclease	_	_	_	_	_	_	_	BeginSeg=Yes
2	L	_	_	_	_	_	_	_	_
3	(	_	_	_	_	_	_	_	_
4	RNase	_	_	_	_	_	_	_	_
5	L	_	_	_	_	_	_	_	_
6	)	_	_	_	_	_	_	_	_
7	is	_	_	_	_	_	_	_	_
8	a	_	_	_	_	_	_	_	_
9	metal	_	_	_	_	_	_	_	_
10	-	_	_	_	_	_	_	_	_
11	ion	_	_	_	_	_	_	_	_
12	-	_	_	_	_	_	_	_	_
13	independent	_	_	_	_	_	_	_	_
14	endoribonuclease	_	_	_	_	_	_	_	_
15	associated	_	_	_	_	_	_	_	BeginSeg=Yes
16	with	_	_	_	_	_	_	_	_
17	antiviral	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	_
19	antibacterial	_	_	_	_	_	_	_	_
20	defense	_	_	_	_	_	_	_	_
21	,	_	_	_	_	_	_	_	_
22	cancer	_	_	_	_	_	_	_	_
23	and	_	_	_	_	_	_	_	_
24	lifespan	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	Despite	_	_	_	_	_	_	_	BeginSeg=Yes
27	the	_	_	_	_	_	_	_	_
28	biological	_	_	_	_	_	_	_	_
29	significance	_	_	_	_	_	_	_	_
30	of	_	_	_	_	_	_	_	_
31	RNase	_	_	_	_	_	_	_	_
32	L	_	_	_	_	_	_	_	_
33	,	_	_	_	_	_	_	_	_
34	the	_	_	_	_	_	_	_	BeginSeg=Yes
35	RNAs	_	_	_	_	_	_	_	_
36	cleaved	_	_	_	_	_	_	_	BeginSeg=Yes
37	by	_	_	_	_	_	_	_	_
38	this	_	_	_	_	_	_	_	_
39	enzyme	_	_	_	_	_	_	_	_
40	are	_	_	_	_	_	_	_	BeginSeg=Yes
41	poorly	_	_	_	_	_	_	_	_
42	defined	_	_	_	_	_	_	_	_
43	.	_	_	_	_	_	_	_	_
44	In	_	_	_	_	_	_	_	BeginSeg=Yes
45	this	_	_	_	_	_	_	_	_
46	study	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	we	_	_	_	_	_	_	_	_
49	used	_	_	_	_	_	_	_	_
50	deep	_	_	_	_	_	_	_	_
51	sequencing	_	_	_	_	_	_	_	_
52	methods	_	_	_	_	_	_	_	_
53	to	_	_	_	_	_	_	_	BeginSeg=Yes
54	reveal	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	frequency	_	_	_	_	_	_	_	_
57	and	_	_	_	_	_	_	_	_
58	location	_	_	_	_	_	_	_	_
59	of	_	_	_	_	_	_	_	_
60	RNase	_	_	_	_	_	_	_	_
61	L	_	_	_	_	_	_	_	_
62	cleavage	_	_	_	_	_	_	_	_
63	sites	_	_	_	_	_	_	_	_
64	within	_	_	_	_	_	_	_	_
65	host	_	_	_	_	_	_	_	_
66	and	_	_	_	_	_	_	_	_
67	viral	_	_	_	_	_	_	_	_
68	RNAs	_	_	_	_	_	_	_	_
69	.	_	_	_	_	_	_	_	_
70	To	_	_	_	_	_	_	_	BeginSeg=Yes
71	make	_	_	_	_	_	_	_	_
72	cDNA	_	_	_	_	_	_	_	_
73	libraries	_	_	_	_	_	_	_	_
74	,	_	_	_	_	_	_	_	_
75	we	_	_	_	_	_	_	_	BeginSeg=Yes
76	exploited	_	_	_	_	_	_	_	_
77	the	_	_	_	_	_	_	_	_
78	2	_	_	_	_	_	_	_	_
79	0	_	_	_	_	_	_	_	_
80	,	_	_	_	_	_	_	_	_
81	3	_	_	_	_	_	_	_	_
82	0	_	_	_	_	_	_	_	_
83	-cyclic	_	_	_	_	_	_	_	_
84	phosphate	_	_	_	_	_	_	_	_
85	at	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	end	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
89	RNA	_	_	_	_	_	_	_	_
90	fragments	_	_	_	_	_	_	_	_
91	produced	_	_	_	_	_	_	_	BeginSeg=Yes
92	by	_	_	_	_	_	_	_	_
93	RNase	_	_	_	_	_	_	_	_
94	L	_	_	_	_	_	_	_	_
95	and	_	_	_	_	_	_	_	_
96	other	_	_	_	_	_	_	_	_
97	metal	_	_	_	_	_	_	_	_
98	-	_	_	_	_	_	_	_	_
99	ion	_	_	_	_	_	_	_	_
100	-	_	_	_	_	_	_	_	_
101	independent	_	_	_	_	_	_	_	_
102	endoribonucleases	_	_	_	_	_	_	_	_
103	.	_	_	_	_	_	_	_	_
104	We	_	_	_	_	_	_	_	BeginSeg=Yes
105	optimized	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	validated	_	_	_	_	_	_	_	_
108	2	_	_	_	_	_	_	_	_
109	0	_	_	_	_	_	_	_	_
110	,	_	_	_	_	_	_	_	_
111	3	_	_	_	_	_	_	_	_
112	0	_	_	_	_	_	_	_	_
113	-cyclic	_	_	_	_	_	_	_	_
114	phosphate	_	_	_	_	_	_	_	_
115	cDNA	_	_	_	_	_	_	_	_
116	synthesis	_	_	_	_	_	_	_	_
117	and	_	_	_	_	_	_	_	_
118	Illumina	_	_	_	_	_	_	_	_
119	sequencing	_	_	_	_	_	_	_	_
120	methods	_	_	_	_	_	_	_	_
121	using	_	_	_	_	_	_	_	BeginSeg=Yes
122	viral	_	_	_	_	_	_	_	_
123	RNAs	_	_	_	_	_	_	_	_
124	cleaved	_	_	_	_	_	_	_	BeginSeg=Yes
125	with	_	_	_	_	_	_	_	_
126	purified	_	_	_	_	_	_	_	_
127	RNase	_	_	_	_	_	_	_	_
128	L	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	viral	_	_	_	_	_	_	_	BeginSeg=Yes
131	RNAs	_	_	_	_	_	_	_	_
132	cleaved	_	_	_	_	_	_	_	BeginSeg=Yes
133	with	_	_	_	_	_	_	_	_
134	purified	_	_	_	_	_	_	_	_
135	RNase	_	_	_	_	_	_	_	_
136	A	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	BeginSeg=Yes
138	RNA	_	_	_	_	_	_	_	_
139	from	_	_	_	_	_	_	_	_
140	uninfected	_	_	_	_	_	_	_	_
141	and	_	_	_	_	_	_	_	_
142	poliovirus	_	_	_	_	_	_	_	_
143	-	_	_	_	_	_	_	_	_
144	infected	_	_	_	_	_	_	_	_
145	HeLa	_	_	_	_	_	_	_	_
146	cells	_	_	_	_	_	_	_	_
147	.	_	_	_	_	_	_	_	_
148	Using	_	_	_	_	_	_	_	BeginSeg=Yes
149	these	_	_	_	_	_	_	_	_
150	methods	_	_	_	_	_	_	_	_
151	,	_	_	_	_	_	_	_	_
152	we	_	_	_	_	_	_	_	BeginSeg=Yes
153	identified	_	_	_	_	_	_	_	_
154	(	_	_	_	_	_	_	_	_
155	i	_	_	_	_	_	_	_	_
156	)	_	_	_	_	_	_	_	_
157	discrete	_	_	_	_	_	_	_	_
158	regions	_	_	_	_	_	_	_	_
159	of	_	_	_	_	_	_	_	_
160	hepatitis	_	_	_	_	_	_	_	_
161	C	_	_	_	_	_	_	_	_
162	virus	_	_	_	_	_	_	_	_
163	and	_	_	_	_	_	_	_	_
164	poliovirus	_	_	_	_	_	_	_	_
165	RNA	_	_	_	_	_	_	_	_
166	genomes	_	_	_	_	_	_	_	_
167	that	_	_	_	_	_	_	_	BeginSeg=Yes
168	were	_	_	_	_	_	_	_	_
169	profoundly	_	_	_	_	_	_	_	_
170	susceptible	_	_	_	_	_	_	_	_
171	to	_	_	_	_	_	_	_	_
172	RNase	_	_	_	_	_	_	_	_
173	L	_	_	_	_	_	_	_	_
174	and	_	_	_	_	_	_	_	_
175	other	_	_	_	_	_	_	_	_
176	single	_	_	_	_	_	_	_	_
177	-	_	_	_	_	_	_	_	_
178	strand	_	_	_	_	_	_	_	_
179	specific	_	_	_	_	_	_	_	_
180	endoribonucleases	_	_	_	_	_	_	_	_
181	,	_	_	_	_	_	_	_	_
182	(	_	_	_	_	_	_	_	BeginSeg=Yes
183	ii	_	_	_	_	_	_	_	_
184	)	_	_	_	_	_	_	_	_
185	RNase	_	_	_	_	_	_	_	_
186	L	_	_	_	_	_	_	_	_
187	-	_	_	_	_	_	_	_	_
188	dependent	_	_	_	_	_	_	_	_
189	and	_	_	_	_	_	_	_	_
190	RNase	_	_	_	_	_	_	_	_
191	L	_	_	_	_	_	_	_	_
192	-	_	_	_	_	_	_	_	_
193	independent	_	_	_	_	_	_	_	_
194	cleavage	_	_	_	_	_	_	_	_
195	sites	_	_	_	_	_	_	_	_
196	within	_	_	_	_	_	_	_	_
197	ribosomal	_	_	_	_	_	_	_	_
198	RNAs	_	_	_	_	_	_	_	_
199	(	_	_	_	_	_	_	_	_
200	rRNAs	_	_	_	_	_	_	_	_
201	)	_	_	_	_	_	_	_	_
202	and	_	_	_	_	_	_	_	_
203	(	_	_	_	_	_	_	_	_
204	iii	_	_	_	_	_	_	_	_
205	)	_	_	_	_	_	_	_	_
206	2	_	_	_	_	_	_	_	_
207	0	_	_	_	_	_	_	_	_
208	,	_	_	_	_	_	_	_	_
209	3	_	_	_	_	_	_	_	_
210	0	_	_	_	_	_	_	_	_
211	-cyclic	_	_	_	_	_	_	_	_
212	phosphates	_	_	_	_	_	_	_	_
213	at	_	_	_	_	_	_	_	_
214	the	_	_	_	_	_	_	_	_
215	ends	_	_	_	_	_	_	_	_
216	of	_	_	_	_	_	_	_	_
217	5S	_	_	_	_	_	_	_	_
218	rRNA	_	_	_	_	_	_	_	_
219	and	_	_	_	_	_	_	_	_
220	U6	_	_	_	_	_	_	_	_
221	snRNA	_	_	_	_	_	_	_	_
222	.	_	_	_	_	_	_	_	_
223	Monitoring	_	_	_	_	_	_	_	BeginSeg=Yes
224	the	_	_	_	_	_	_	_	_
225	frequency	_	_	_	_	_	_	_	_
226	and	_	_	_	_	_	_	_	_
227	location	_	_	_	_	_	_	_	_
228	of	_	_	_	_	_	_	_	_
229	metal	_	_	_	_	_	_	_	_
230	-	_	_	_	_	_	_	_	_
231	ion	_	_	_	_	_	_	_	_
232	-	_	_	_	_	_	_	_	_
233	independent	_	_	_	_	_	_	_	_
234	endoribonuclease	_	_	_	_	_	_	_	_
235	cleavage	_	_	_	_	_	_	_	_
236	sites	_	_	_	_	_	_	_	_
237	within	_	_	_	_	_	_	_	_
238	host	_	_	_	_	_	_	_	_
239	and	_	_	_	_	_	_	_	_
240	viral	_	_	_	_	_	_	_	_
241	RNAs	_	_	_	_	_	_	_	_
242	reveals	_	_	_	_	_	_	_	_
243	,	_	_	_	_	_	_	_	_
244	in	_	_	_	_	_	_	_	BeginSeg=Yes
245	part	_	_	_	_	_	_	_	_
246	,	_	_	_	_	_	_	_	_
247	how	_	_	_	_	_	_	_	_
248	these	_	_	_	_	_	_	_	_
249	enzymes	_	_	_	_	_	_	_	_
250	contribute	_	_	_	_	_	_	_	_
251	to	_	_	_	_	_	_	_	_
252	health	_	_	_	_	_	_	_	_
253	and	_	_	_	_	_	_	_	_
254	disease	_	_	_	_	_	_	_	_
255	.	_	_	_	_	_	_	_	_

# newdoc_id = 1f7c4b6fc91f3143baa4824a7f8050f16d9bcccd
1	Background	_	_	_	_	_	_	_	BeginSeg=Yes
2	:	_	_	_	_	_	_	_	_
3	Porcine	_	_	_	_	_	_	_	BeginSeg=Yes
4	reproductive	_	_	_	_	_	_	_	_
5	and	_	_	_	_	_	_	_	_
6	respiratory	_	_	_	_	_	_	_	_
7	syndrome	_	_	_	_	_	_	_	_
8	(	_	_	_	_	_	_	_	_
9	PRRS	_	_	_	_	_	_	_	_
10	)	_	_	_	_	_	_	_	_
11	viruses	_	_	_	_	_	_	_	_
12	are	_	_	_	_	_	_	_	_
13	a	_	_	_	_	_	_	_	_
14	major	_	_	_	_	_	_	_	_
15	cause	_	_	_	_	_	_	_	_
16	of	_	_	_	_	_	_	_	_
17	disease	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	_
19	economic	_	_	_	_	_	_	_	_
20	loss	_	_	_	_	_	_	_	_
21	in	_	_	_	_	_	_	_	_
22	pigs	_	_	_	_	_	_	_	_
23	worldwide	_	_	_	_	_	_	_	_
24	.	_	_	_	_	_	_	_	_
25	High	_	_	_	_	_	_	_	BeginSeg=Yes
26	genetic	_	_	_	_	_	_	_	_
27	diversity	_	_	_	_	_	_	_	_
28	among	_	_	_	_	_	_	_	_
29	PRRSV	_	_	_	_	_	_	_	_
30	strains	_	_	_	_	_	_	_	_
31	is	_	_	_	_	_	_	_	_
32	problematic	_	_	_	_	_	_	_	_
33	for	_	_	_	_	_	_	_	_
34	successful	_	_	_	_	_	_	_	_
35	disease	_	_	_	_	_	_	_	_
36	control	_	_	_	_	_	_	_	_
37	by	_	_	_	_	_	_	_	_
38	vaccination	_	_	_	_	_	_	_	_
39	.	_	_	_	_	_	_	_	_
40	Mosaic	_	_	_	_	_	_	_	BeginSeg=Yes
41	DNA	_	_	_	_	_	_	_	_
42	and	_	_	_	_	_	_	_	_
43	vaccinia	_	_	_	_	_	_	_	_
44	(	_	_	_	_	_	_	_	_
45	VACV	_	_	_	_	_	_	_	_
46	)	_	_	_	_	_	_	_	_
47	vaccines	_	_	_	_	_	_	_	_
48	were	_	_	_	_	_	_	_	_
49	developed	_	_	_	_	_	_	_	_
50	in	_	_	_	_	_	_	_	BeginSeg=Yes
51	order	_	_	_	_	_	_	_	_
52	to	_	_	_	_	_	_	_	_
53	improve	_	_	_	_	_	_	_	_
54	protection	_	_	_	_	_	_	_	_
55	against	_	_	_	_	_	_	_	_
56	heterologous	_	_	_	_	_	_	_	_
57	PRRSV	_	_	_	_	_	_	_	_
58	strains	_	_	_	_	_	_	_	_
59	.	_	_	_	_	_	_	_	_
60	Methods	_	_	_	_	_	_	_	BeginSeg=Yes
61	:	_	_	_	_	_	_	_	_
62	Piglets	_	_	_	_	_	_	_	BeginSeg=Yes
63	were	_	_	_	_	_	_	_	_
64	primed	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	_
66	boosted	_	_	_	_	_	_	_	_
67	with	_	_	_	_	_	_	_	_
68	GP5-Mosaic	_	_	_	_	_	_	_	_
69	DNA	_	_	_	_	_	_	_	_
70	vaccine	_	_	_	_	_	_	_	_
71	and	_	_	_	_	_	_	_	_
72	recombinant	_	_	_	_	_	_	_	_
73	GP5-Mosaic	_	_	_	_	_	_	_	_
74	VACV	_	_	_	_	_	_	_	_
75	(	_	_	_	_	_	_	_	_
76	rGP5-Mosaic	_	_	_	_	_	_	_	_
77	VACV	_	_	_	_	_	_	_	_
78	)	_	_	_	_	_	_	_	_
79	,	_	_	_	_	_	_	_	_
80	respectively	_	_	_	_	_	_	_	_
81	.	_	_	_	_	_	_	_	_
82	Pigs	_	_	_	_	_	_	_	BeginSeg=Yes
83	vaccinated	_	_	_	_	_	_	_	BeginSeg=Yes
84	with	_	_	_	_	_	_	_	_
85	rGP5-WT	_	_	_	_	_	_	_	_
86	(	_	_	_	_	_	_	_	_
87	VR2332	_	_	_	_	_	_	_	_
88	)	_	_	_	_	_	_	_	_
89	DNA	_	_	_	_	_	_	_	_
90	and	_	_	_	_	_	_	_	_
91	rGP5-WT	_	_	_	_	_	_	_	_
92	VACV	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	or	_	_	_	_	_	_	_	_
95	empty	_	_	_	_	_	_	_	_
96	vector	_	_	_	_	_	_	_	_
97	DNA	_	_	_	_	_	_	_	_
98	and	_	_	_	_	_	_	_	_
99	empty	_	_	_	_	_	_	_	_
100	VACV	_	_	_	_	_	_	_	_
101	respectively	_	_	_	_	_	_	_	_
102	,	_	_	_	_	_	_	_	_
103	served	_	_	_	_	_	_	_	BeginSeg=Yes
104	as	_	_	_	_	_	_	_	_
105	controls	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	Virus	_	_	_	_	_	_	_	BeginSeg=Yes
108	challenge	_	_	_	_	_	_	_	_
109	was	_	_	_	_	_	_	_	_
110	given	_	_	_	_	_	_	_	_
111	to	_	_	_	_	_	_	_	_
112	separate	_	_	_	_	_	_	_	_
113	groups	_	_	_	_	_	_	_	_
114	of	_	_	_	_	_	_	_	_
115	vaccinated	_	_	_	_	_	_	_	_
116	pigs	_	_	_	_	_	_	_	_
117	with	_	_	_	_	_	_	_	_
118	VR2332	_	_	_	_	_	_	_	_
119	or	_	_	_	_	_	_	_	_
120	MN184C.	_	_	_	_	_	_	_	_
121	Necropsies	_	_	_	_	_	_	_	BeginSeg=Yes
122	were	_	_	_	_	_	_	_	_
123	performed	_	_	_	_	_	_	_	_
124	14	_	_	_	_	_	_	_	_
125	days	_	_	_	_	_	_	_	_
126	after	_	_	_	_	_	_	_	_
127	challenge	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	Results	_	_	_	_	_	_	_	BeginSeg=Yes
130	:	_	_	_	_	_	_	_	_
131	Vaccination	_	_	_	_	_	_	_	BeginSeg=Yes
132	with	_	_	_	_	_	_	_	_
133	the	_	_	_	_	_	_	_	_
134	GP5-Mosaic	_	_	_	_	_	_	_	_
135	-	_	_	_	_	_	_	_	_
136	based	_	_	_	_	_	_	_	_
137	vaccines	_	_	_	_	_	_	_	_
138	resulted	_	_	_	_	_	_	_	_
139	in	_	_	_	_	_	_	_	_
140	cellular	_	_	_	_	_	_	_	_
141	reactivity	_	_	_	_	_	_	_	_
142	and	_	_	_	_	_	_	_	_
143	higher	_	_	_	_	_	_	_	_
144	levels	_	_	_	_	_	_	_	_
145	of	_	_	_	_	_	_	_	_
146	neutralizing	_	_	_	_	_	_	_	_
147	antibodies	_	_	_	_	_	_	_	_
148	to	_	_	_	_	_	_	_	_
149	both	_	_	_	_	_	_	_	_
150	VR2332	_	_	_	_	_	_	_	_
151	and	_	_	_	_	_	_	_	_
152	MN184C	_	_	_	_	_	_	_	_
153	PRRSV	_	_	_	_	_	_	_	_
154	strains	_	_	_	_	_	_	_	_
155	.	_	_	_	_	_	_	_	_
156	In	_	_	_	_	_	_	_	BeginSeg=Yes
157	contrast	_	_	_	_	_	_	_	_
158	,	_	_	_	_	_	_	_	_
159	vaccination	_	_	_	_	_	_	_	_
160	of	_	_	_	_	_	_	_	_
161	animals	_	_	_	_	_	_	_	_
162	with	_	_	_	_	_	_	_	_
163	the	_	_	_	_	_	_	_	_
164	GP5-WT	_	_	_	_	_	_	_	_
165	vaccines	_	_	_	_	_	_	_	_
166	induced	_	_	_	_	_	_	_	_
167	responses	_	_	_	_	_	_	_	_
168	only	_	_	_	_	_	_	_	_
169	to	_	_	_	_	_	_	_	_
170	VR2332	_	_	_	_	_	_	_	_
171	.	_	_	_	_	_	_	_	_
172	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
173	,	_	_	_	_	_	_	_	_
174	vaccination	_	_	_	_	_	_	_	_
175	with	_	_	_	_	_	_	_	_
176	the	_	_	_	_	_	_	_	_
177	GP5-Mosaic	_	_	_	_	_	_	_	_
178	based	_	_	_	_	_	_	_	_
179	vaccines	_	_	_	_	_	_	_	_
180	resulted	_	_	_	_	_	_	_	_
181	in	_	_	_	_	_	_	_	_
182	protection	_	_	_	_	_	_	_	_
183	against	_	_	_	_	_	_	_	_
184	challenge	_	_	_	_	_	_	_	_
185	with	_	_	_	_	_	_	_	_
186	two	_	_	_	_	_	_	_	_
187	heterologous	_	_	_	_	_	_	_	_
188	virus	_	_	_	_	_	_	_	_
189	strains	_	_	_	_	_	_	_	_
190	,	_	_	_	_	_	_	_	_
191	as	_	_	_	_	_	_	_	BeginSeg=Yes
192	demonstrated	_	_	_	_	_	_	_	_
193	by	_	_	_	_	_	_	_	_
194	the	_	_	_	_	_	_	_	_
195	significantly	_	_	_	_	_	_	_	_
196	lower	_	_	_	_	_	_	_	_
197	viral	_	_	_	_	_	_	_	_
198	loads	_	_	_	_	_	_	_	_
199	in	_	_	_	_	_	_	_	_
200	serum	_	_	_	_	_	_	_	_
201	,	_	_	_	_	_	_	_	_
202	tissues	_	_	_	_	_	_	_	_
203	,	_	_	_	_	_	_	_	_
204	porcine	_	_	_	_	_	_	_	_
205	alveolar	_	_	_	_	_	_	_	_
206	macrophages	_	_	_	_	_	_	_	_
207	(	_	_	_	_	_	_	_	_
208	PAMs	_	_	_	_	_	_	_	_
209	)	_	_	_	_	_	_	_	_
210	,	_	_	_	_	_	_	_	_
211	and	_	_	_	_	_	_	_	_
212	bronchoalveolar	_	_	_	_	_	_	_	_
213	lavage	_	_	_	_	_	_	_	_
214	(	_	_	_	_	_	_	_	_
215	BAL	_	_	_	_	_	_	_	_
216	)	_	_	_	_	_	_	_	_
217	fluids	_	_	_	_	_	_	_	_
218	,	_	_	_	_	_	_	_	_
219	and	_	_	_	_	_	_	_	_
220	less	_	_	_	_	_	_	_	_
221	severe	_	_	_	_	_	_	_	_
222	lung	_	_	_	_	_	_	_	_
223	lesions	_	_	_	_	_	_	_	_
224	after	_	_	_	_	_	_	_	_
225	challenge	_	_	_	_	_	_	_	_
226	with	_	_	_	_	_	_	_	_
227	either	_	_	_	_	_	_	_	_
228	MN184C	_	_	_	_	_	_	_	_
229	or	_	_	_	_	_	_	_	_
230	VR2332	_	_	_	_	_	_	_	_
231	,	_	_	_	_	_	_	_	_
232	which	_	_	_	_	_	_	_	BeginSeg=Yes
233	have	_	_	_	_	_	_	_	_
234	only	_	_	_	_	_	_	_	_
235	85	_	_	_	_	_	_	_	_
236	%	_	_	_	_	_	_	_	_
237	identity	_	_	_	_	_	_	_	_
238	.	_	_	_	_	_	_	_	_
239	In	_	_	_	_	_	_	_	BeginSeg=Yes
240	contrast	_	_	_	_	_	_	_	_
241	,	_	_	_	_	_	_	_	_
242	significant	_	_	_	_	_	_	_	_
243	protection	_	_	_	_	_	_	_	_
244	by	_	_	_	_	_	_	_	_
245	the	_	_	_	_	_	_	_	_
246	GP5-WT	_	_	_	_	_	_	_	_
247	based	_	_	_	_	_	_	_	_
248	vaccines	_	_	_	_	_	_	_	_
249	was	_	_	_	_	_	_	_	_
250	only	_	_	_	_	_	_	_	_
251	achieved	_	_	_	_	_	_	_	_
252	against	_	_	_	_	_	_	_	_
253	the	_	_	_	_	_	_	_	_
254	VR2332	_	_	_	_	_	_	_	_
255	strain	_	_	_	_	_	_	_	_
256	.	_	_	_	_	_	_	_	_
257	Conclusions	_	_	_	_	_	_	_	BeginSeg=Yes
258	:	_	_	_	_	_	_	_	_
259	GP5-Mosaic	_	_	_	_	_	_	_	BeginSeg=Yes
260	vaccines	_	_	_	_	_	_	_	_
261	,	_	_	_	_	_	_	_	_
262	using	_	_	_	_	_	_	_	BeginSeg=Yes
263	a	_	_	_	_	_	_	_	_
264	DNA	_	_	_	_	_	_	_	_
265	-	_	_	_	_	_	_	_	_
266	prime	_	_	_	_	_	_	_	_
267	/	_	_	_	_	_	_	_	_
268	VACV	_	_	_	_	_	_	_	_
269	boost	_	_	_	_	_	_	_	_
270	regimen	_	_	_	_	_	_	_	_
271	,	_	_	_	_	_	_	_	_
272	conferred	_	_	_	_	_	_	_	BeginSeg=Yes
273	protection	_	_	_	_	_	_	_	_
274	in	_	_	_	_	_	_	_	_
275	pigs	_	_	_	_	_	_	_	_
276	against	_	_	_	_	_	_	_	_
277	heterologous	_	_	_	_	_	_	_	_
278	viruses	_	_	_	_	_	_	_	_
279	.	_	_	_	_	_	_	_	_

# newdoc_id = 202409fc9fbc3fdc1a7dd3ef3e690880287c117c
1	Localization	_	_	_	_	_	_	_	BeginSeg=Yes
2	of	_	_	_	_	_	_	_	_
3	neutralizing	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	serotype	_	_	_	_	_	_	_	_
6	specific	_	_	_	_	_	_	_	_
7	epitopes	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	_
9	infectious	_	_	_	_	_	_	_	_
10	bronchitis	_	_	_	_	_	_	_	_
11	virus	_	_	_	_	_	_	_	_
12	has	_	_	_	_	_	_	_	_
13	been	_	_	_	_	_	_	_	_
14	difficult	_	_	_	_	_	_	_	_
15	because	_	_	_	_	_	_	_	BeginSeg=Yes
16	these	_	_	_	_	_	_	_	_
17	epitopes	_	_	_	_	_	_	_	_
18	are	_	_	_	_	_	_	_	_
19	conformationally	_	_	_	_	_	_	_	_
20	dependent	_	_	_	_	_	_	_	_
21	.	_	_	_	_	_	_	_	_
22	We	_	_	_	_	_	_	_	BeginSeg=Yes
23	identified	_	_	_	_	_	_	_	_
24	amino	_	_	_	_	_	_	_	_
25	acids	_	_	_	_	_	_	_	_
26	involved	_	_	_	_	_	_	_	BeginSeg=Yes
27	in	_	_	_	_	_	_	_	_
28	a	_	_	_	_	_	_	_	_
29	serotype	_	_	_	_	_	_	_	_
30	specific	_	_	_	_	_	_	_	_
31	,	_	_	_	_	_	_	_	_
32	conformationally	_	_	_	_	_	_	_	_
33	dependent	_	_	_	_	_	_	_	_
34	epitope	_	_	_	_	_	_	_	_
35	by	_	_	_	_	_	_	_	BeginSeg=Yes
36	analysis	_	_	_	_	_	_	_	_
37	of	_	_	_	_	_	_	_	_
38	the	_	_	_	_	_	_	_	_
39	S1	_	_	_	_	_	_	_	_
40	gene	_	_	_	_	_	_	_	_
41	of	_	_	_	_	_	_	_	_
42	13	_	_	_	_	_	_	_	_
43	monoclonal	_	_	_	_	_	_	_	_
44	antibody	_	_	_	_	_	_	_	_
45	-	_	_	_	_	_	_	_	_
46	neutralization	_	_	_	_	_	_	_	_
47	-	_	_	_	_	_	_	_	_
48	resistant	_	_	_	_	_	_	_	_
49	mutants	_	_	_	_	_	_	_	_
50	.	_	_	_	_	_	_	_	_
51	Substitutions	_	_	_	_	_	_	_	BeginSeg=Yes
52	in	_	_	_	_	_	_	_	_
53	the	_	_	_	_	_	_	_	_
54	predicted	_	_	_	_	_	_	_	_
55	amino	_	_	_	_	_	_	_	_
56	acid	_	_	_	_	_	_	_	_
57	sequence	_	_	_	_	_	_	_	_
58	of	_	_	_	_	_	_	_	_
59	these	_	_	_	_	_	_	_	_
60	mutants	_	_	_	_	_	_	_	_
61	were	_	_	_	_	_	_	_	_
62	located	_	_	_	_	_	_	_	_
63	at	_	_	_	_	_	_	_	_
64	residues	_	_	_	_	_	_	_	_
65	304	_	_	_	_	_	_	_	_
66	and/or	_	_	_	_	_	_	_	_
67	386	_	_	_	_	_	_	_	_
68	.	_	_	_	_	_	_	_	_
69	Most	_	_	_	_	_	_	_	BeginSeg=Yes
70	of	_	_	_	_	_	_	_	_
71	the	_	_	_	_	_	_	_	_
72	substitutions	_	_	_	_	_	_	_	_
73	at	_	_	_	_	_	_	_	_
74	residue	_	_	_	_	_	_	_	_
75	304	_	_	_	_	_	_	_	_
76	were	_	_	_	_	_	_	_	_
77	from	_	_	_	_	_	_	_	_
78	threonine	_	_	_	_	_	_	_	_
79	to	_	_	_	_	_	_	_	_
80	isoleucine	_	_	_	_	_	_	_	_
81	,	_	_	_	_	_	_	_	_
82	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
83	the	_	_	_	_	_	_	_	_
84	substitutions	_	_	_	_	_	_	_	_
85	at	_	_	_	_	_	_	_	_
86	residue	_	_	_	_	_	_	_	_
87	386	_	_	_	_	_	_	_	_
88	were	_	_	_	_	_	_	_	_
89	from	_	_	_	_	_	_	_	_
90	arginine	_	_	_	_	_	_	_	_
91	to	_	_	_	_	_	_	_	_
92	proline	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	histidine	_	_	_	_	_	_	_	_
95	,	_	_	_	_	_	_	_	_
96	cysteine	_	_	_	_	_	_	_	_
97	,	_	_	_	_	_	_	_	_
98	or	_	_	_	_	_	_	_	_
99	tryptophan	_	_	_	_	_	_	_	_
100	.	_	_	_	_	_	_	_	_
101	Based	_	_	_	_	_	_	_	BeginSeg=Yes
102	on	_	_	_	_	_	_	_	_
103	this	_	_	_	_	_	_	_	_
104	data	_	_	_	_	_	_	_	_
105	,	_	_	_	_	_	_	_	_
106	it	_	_	_	_	_	_	_	BeginSeg=Yes
107	appears	_	_	_	_	_	_	_	_
108	that	_	_	_	_	_	_	_	_
109	AA	_	_	_	_	_	_	_	_
110	residues	_	_	_	_	_	_	_	_
111	at	_	_	_	_	_	_	_	_
112	304	_	_	_	_	_	_	_	_
113	and	_	_	_	_	_	_	_	_
114	386	_	_	_	_	_	_	_	_
115	on	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	_
117	S1	_	_	_	_	_	_	_	_
118	glycoprotein	_	_	_	_	_	_	_	_
119	are	_	_	_	_	_	_	_	_
120	involved	_	_	_	_	_	_	_	_
121	in	_	_	_	_	_	_	_	_
122	a	_	_	_	_	_	_	_	_
123	virus	_	_	_	_	_	_	_	_
124	neutralizing	_	_	_	_	_	_	_	_
125	serotype	_	_	_	_	_	_	_	_
126	specific	_	_	_	_	_	_	_	_
127	epitope	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_

# newdoc_id = 24c534c1f480d949f6ceeab0a60c1d7958ee34af
1	Topic	_	_	_	_	_	_	_	BeginSeg=Yes
2	modeling	_	_	_	_	_	_	_	_
3	is	_	_	_	_	_	_	_	_
4	frequently	_	_	_	_	_	_	_	_
5	employed	_	_	_	_	_	_	_	_
6	for	_	_	_	_	_	_	_	BeginSeg=Yes
7	discovering	_	_	_	_	_	_	_	_
8	structures	_	_	_	_	_	_	_	_
9	(	_	_	_	_	_	_	_	_
10	or	_	_	_	_	_	_	_	_
11	patterns	_	_	_	_	_	_	_	_
12	)	_	_	_	_	_	_	_	_
13	in	_	_	_	_	_	_	_	_
14	a	_	_	_	_	_	_	_	_
15	corpus	_	_	_	_	_	_	_	_
16	of	_	_	_	_	_	_	_	_
17	documents	_	_	_	_	_	_	_	_
18	.	_	_	_	_	_	_	_	_
19	Its	_	_	_	_	_	_	_	BeginSeg=Yes
20	utility	_	_	_	_	_	_	_	_
21	in	_	_	_	_	_	_	_	_
22	text	_	_	_	_	_	_	_	_
23	-	_	_	_	_	_	_	_	_
24	mining	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	document	_	_	_	_	_	_	_	_
27	retrieval	_	_	_	_	_	_	_	_
28	tasks	_	_	_	_	_	_	_	_
29	in	_	_	_	_	_	_	_	_
30	various	_	_	_	_	_	_	_	_
31	fields	_	_	_	_	_	_	_	_
32	of	_	_	_	_	_	_	_	_
33	scientific	_	_	_	_	_	_	_	_
34	research	_	_	_	_	_	_	_	_
35	is	_	_	_	_	_	_	_	_
36	rather	_	_	_	_	_	_	_	_
37	well	_	_	_	_	_	_	_	_
38	known	_	_	_	_	_	_	_	_
39	.	_	_	_	_	_	_	_	_
40	An	_	_	_	_	_	_	_	BeginSeg=Yes
41	unsupervised	_	_	_	_	_	_	_	_
42	machine	_	_	_	_	_	_	_	_
43	learning	_	_	_	_	_	_	_	_
44	approach	_	_	_	_	_	_	_	_
45	,	_	_	_	_	_	_	_	_
46	Latent	_	_	_	_	_	_	_	_
47	Dirichlet	_	_	_	_	_	_	_	_
48	Allocation	_	_	_	_	_	_	_	_
49	(	_	_	_	_	_	_	_	_
50	LDA	_	_	_	_	_	_	_	_
51	)	_	_	_	_	_	_	_	_
52	has	_	_	_	_	_	_	_	_
53	particularly	_	_	_	_	_	_	_	_
54	been	_	_	_	_	_	_	_	_
55	utilized	_	_	_	_	_	_	_	_
56	for	_	_	_	_	_	_	_	BeginSeg=Yes
57	identifying	_	_	_	_	_	_	_	_
58	latent	_	_	_	_	_	_	_	_
59	(	_	_	_	_	_	_	_	_
60	or	_	_	_	_	_	_	_	_
61	hidden	_	_	_	_	_	_	_	_
62	)	_	_	_	_	_	_	_	_
63	topics	_	_	_	_	_	_	_	_
64	in	_	_	_	_	_	_	_	_
65	document	_	_	_	_	_	_	_	_
66	collections	_	_	_	_	_	_	_	_
67	and	_	_	_	_	_	_	_	BeginSeg=Yes
68	for	_	_	_	_	_	_	_	_
69	deciphering	_	_	_	_	_	_	_	_
70	the	_	_	_	_	_	_	_	_
71	words	_	_	_	_	_	_	_	_
72	that	_	_	_	_	_	_	_	BeginSeg=Yes
73	define	_	_	_	_	_	_	_	_
74	one	_	_	_	_	_	_	_	_
75	or	_	_	_	_	_	_	_	_
76	more	_	_	_	_	_	_	_	_
77	topics	_	_	_	_	_	_	_	_
78	using	_	_	_	_	_	_	_	BeginSeg=Yes
79	a	_	_	_	_	_	_	_	_
80	generative	_	_	_	_	_	_	_	_
81	statistical	_	_	_	_	_	_	_	_
82	model	_	_	_	_	_	_	_	_
83	.	_	_	_	_	_	_	_	_
84	Here	_	_	_	_	_	_	_	BeginSeg=Yes
85	we	_	_	_	_	_	_	_	_
86	describe	_	_	_	_	_	_	_	_
87	how	_	_	_	_	_	_	_	BeginSeg=Yes
88	SARS	_	_	_	_	_	_	_	_
89	-	_	_	_	_	_	_	_	_
90	CoV-2	_	_	_	_	_	_	_	_
91	genomic	_	_	_	_	_	_	_	_
92	mutation	_	_	_	_	_	_	_	_
93	profiles	_	_	_	_	_	_	_	_
94	can	_	_	_	_	_	_	_	_
95	be	_	_	_	_	_	_	_	_
96	structured	_	_	_	_	_	_	_	_
97	into	_	_	_	_	_	_	_	_
98	a	_	_	_	_	_	_	_	_
99	'	_	_	_	_	_	_	_	_
100	Bag	_	_	_	_	_	_	_	_
101	of	_	_	_	_	_	_	_	_
102	Words	_	_	_	_	_	_	_	_
103	'	_	_	_	_	_	_	_	_
104	to	_	_	_	_	_	_	_	BeginSeg=Yes
105	enable	_	_	_	_	_	_	_	_
106	identification	_	_	_	_	_	_	_	_
107	of	_	_	_	_	_	_	_	_
108	signatures	_	_	_	_	_	_	_	_
109	(	_	_	_	_	_	_	_	_
110	topics	_	_	_	_	_	_	_	_
111	)	_	_	_	_	_	_	_	_
112	and	_	_	_	_	_	_	_	_
113	their	_	_	_	_	_	_	_	_
114	probabilistic	_	_	_	_	_	_	_	_
115	distribution	_	_	_	_	_	_	_	_
116	across	_	_	_	_	_	_	_	_
117	various	_	_	_	_	_	_	_	_
118	genomes	_	_	_	_	_	_	_	_
119	using	_	_	_	_	_	_	_	BeginSeg=Yes
120	LDA	_	_	_	_	_	_	_	_
121	.	_	_	_	_	_	_	_	_
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276	-	_	_	_	_	_	_	_	_
277	CoV-2	_	_	_	_	_	_	_	_
278	genomes	_	_	_	_	_	_	_	_
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286	.	_	_	_	_	_	_	_	_

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13	points	_	_	_	_	_	_	_	_
14	in	_	_	_	_	_	_	_	_
15	R	_	_	_	_	_	_	_	_
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17	.	_	_	_	_	_	_	_	_
18	A	_	_	_	_	_	_	_	BeginSeg=Yes
19	triangulation	_	_	_	_	_	_	_	_
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21	a	_	_	_	_	_	_	_	_
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23	polyhedron	_	_	_	_	_	_	_	_
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25	a	_	_	_	_	_	_	_	_
26	decomposition	_	_	_	_	_	_	_	_
27	into	_	_	_	_	_	_	_	_
28	a	_	_	_	_	_	_	_	_
29	finite	_	_	_	_	_	_	_	_
30	number	_	_	_	_	_	_	_	_
31	of	_	_	_	_	_	_	_	_
32	3-simplices	_	_	_	_	_	_	_	_
33	such	_	_	_	_	_	_	_	BeginSeg=Yes
34	that	_	_	_	_	_	_	_	_
35	any	_	_	_	_	_	_	_	_
36	two	_	_	_	_	_	_	_	_
37	intersect	_	_	_	_	_	_	_	_
38	in	_	_	_	_	_	_	_	_
39	a	_	_	_	_	_	_	_	_
40	common	_	_	_	_	_	_	_	_
41	face	_	_	_	_	_	_	_	_
42	or	_	_	_	_	_	_	_	BeginSeg=Yes
43	are	_	_	_	_	_	_	_	_
44	disjoint	_	_	_	_	_	_	_	_
45	.	_	_	_	_	_	_	_	_
46	A	_	_	_	_	_	_	_	BeginSeg=Yes
47	simplicial	_	_	_	_	_	_	_	_
48	dissection	_	_	_	_	_	_	_	_
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50	a	_	_	_	_	_	_	_	_
51	decomposition	_	_	_	_	_	_	_	_
52	into	_	_	_	_	_	_	_	_
53	a	_	_	_	_	_	_	_	_
54	finite	_	_	_	_	_	_	_	_
55	number	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	3-simplices	_	_	_	_	_	_	_	_
58	such	_	_	_	_	_	_	_	BeginSeg=Yes
59	that	_	_	_	_	_	_	_	_
60	no	_	_	_	_	_	_	_	_
61	two	_	_	_	_	_	_	_	_
62	share	_	_	_	_	_	_	_	_
63	an	_	_	_	_	_	_	_	_
64	interior	_	_	_	_	_	_	_	_
65	point	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	We	_	_	_	_	_	_	_	BeginSeg=Yes
68	present	_	_	_	_	_	_	_	_
69	an	_	_	_	_	_	_	_	_
70	algorithm	_	_	_	_	_	_	_	_
71	to	_	_	_	_	_	_	_	BeginSeg=Yes
72	classify	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	simplicial	_	_	_	_	_	_	_	_
75	dissections	_	_	_	_	_	_	_	_
76	of	_	_	_	_	_	_	_	_
77	a	_	_	_	_	_	_	_	_
78	regular	_	_	_	_	_	_	_	_
79	polyhedron	_	_	_	_	_	_	_	_
80	under	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	symmetry	_	_	_	_	_	_	_	_
83	group	_	_	_	_	_	_	_	_
84	of	_	_	_	_	_	_	_	_
85	the	_	_	_	_	_	_	_	_
86	prolyhedron	_	_	_	_	_	_	_	_
87	.	_	_	_	_	_	_	_	_

# newdoc_id = 273377715ca866a5763943b5b86583bf6d6f91f1
1	For	_	_	_	_	_	_	_	BeginSeg=Yes
2	infectious	_	_	_	_	_	_	_	_
3	-	_	_	_	_	_	_	_	_
4	disease	_	_	_	_	_	_	_	_
5	outbreaks	_	_	_	_	_	_	_	_
6	,	_	_	_	_	_	_	_	_
7	clinical	_	_	_	_	_	_	_	_
8	solutions	_	_	_	_	_	_	_	_
9	typically	_	_	_	_	_	_	_	_
10	focus	_	_	_	_	_	_	_	_
11	on	_	_	_	_	_	_	_	_
12	efficient	_	_	_	_	_	_	_	_
13	pathogen	_	_	_	_	_	_	_	_
14	destruction	_	_	_	_	_	_	_	_
15	.	_	_	_	_	_	_	_	_
16	However	_	_	_	_	_	_	_	BeginSeg=Yes
17	,	_	_	_	_	_	_	_	_
18	the	_	_	_	_	_	_	_	_
19	COVID-19	_	_	_	_	_	_	_	_
20	pandemic	_	_	_	_	_	_	_	_
21	provides	_	_	_	_	_	_	_	_
22	a	_	_	_	_	_	_	_	_
23	reminder	_	_	_	_	_	_	_	_
24	that	_	_	_	_	_	_	_	BeginSeg=Yes
25	infectious	_	_	_	_	_	_	_	_
26	diseases	_	_	_	_	_	_	_	_
27	are	_	_	_	_	_	_	_	_
28	complex	_	_	_	_	_	_	_	_
29	,	_	_	_	_	_	_	_	_
30	multisystem	_	_	_	_	_	_	_	_
31	conditions	_	_	_	_	_	_	_	_
32	,	_	_	_	_	_	_	_	_
33	and	_	_	_	_	_	_	_	BeginSeg=Yes
34	a	_	_	_	_	_	_	_	_
35	holistic	_	_	_	_	_	_	_	_
36	understanding	_	_	_	_	_	_	_	_
37	will	_	_	_	_	_	_	_	_
38	be	_	_	_	_	_	_	_	_
39	necessary	_	_	_	_	_	_	_	_
40	to	_	_	_	_	_	_	_	BeginSeg=Yes
41	maximize	_	_	_	_	_	_	_	_
42	survival	_	_	_	_	_	_	_	_
43	.	_	_	_	_	_	_	_	_
44	For	_	_	_	_	_	_	_	BeginSeg=Yes
45	COVID-19	_	_	_	_	_	_	_	_
46	and	_	_	_	_	_	_	_	_
47	all	_	_	_	_	_	_	_	_
48	other	_	_	_	_	_	_	_	_
49	infectious	_	_	_	_	_	_	_	_
50	diseases	_	_	_	_	_	_	_	_
51	,	_	_	_	_	_	_	_	_
52	metabolic	_	_	_	_	_	_	_	_
53	processes	_	_	_	_	_	_	_	_
54	are	_	_	_	_	_	_	_	_
55	intimately	_	_	_	_	_	_	_	_
56	connected	_	_	_	_	_	_	_	_
57	to	_	_	_	_	_	_	_	_
58	the	_	_	_	_	_	_	_	_
59	mechanisms	_	_	_	_	_	_	_	_
60	of	_	_	_	_	_	_	_	_
61	disease	_	_	_	_	_	_	_	_
62	pathogenesis	_	_	_	_	_	_	_	_
63	and	_	_	_	_	_	_	_	_
64	the	_	_	_	_	_	_	_	_
65	resulting	_	_	_	_	_	_	_	_
66	pathology	_	_	_	_	_	_	_	_
67	and	_	_	_	_	_	_	_	_
68	pathophysiology	_	_	_	_	_	_	_	_
69	,	_	_	_	_	_	_	_	_
70	as	_	_	_	_	_	_	_	_
71	well	_	_	_	_	_	_	_	_
72	as	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	host	_	_	_	_	_	_	_	_
75	defence	_	_	_	_	_	_	_	_
76	response	_	_	_	_	_	_	_	_
77	to	_	_	_	_	_	_	_	_
78	the	_	_	_	_	_	_	_	_
79	infection	_	_	_	_	_	_	_	_
80	.	_	_	_	_	_	_	_	_
81	Here	_	_	_	_	_	_	_	BeginSeg=Yes
82	,	_	_	_	_	_	_	_	_
83	I	_	_	_	_	_	_	_	_
84	examine	_	_	_	_	_	_	_	_
85	the	_	_	_	_	_	_	_	_
86	relationship	_	_	_	_	_	_	_	_
87	between	_	_	_	_	_	_	_	_
88	metabolism	_	_	_	_	_	_	_	_
89	and	_	_	_	_	_	_	_	_
90	COVID-19	_	_	_	_	_	_	_	_
91	.	_	_	_	_	_	_	_	_
92	I	_	_	_	_	_	_	_	BeginSeg=Yes
93	discuss	_	_	_	_	_	_	_	_
94	why	_	_	_	_	_	_	_	_
95	preexisting	_	_	_	_	_	_	_	_
96	metabolic	_	_	_	_	_	_	_	_
97	abnormalities	_	_	_	_	_	_	_	_
98	,	_	_	_	_	_	_	_	_
99	such	_	_	_	_	_	_	_	BeginSeg=Yes
100	as	_	_	_	_	_	_	_	_
101	type	_	_	_	_	_	_	_	_
102	2	_	_	_	_	_	_	_	_
103	diabetes	_	_	_	_	_	_	_	_
104	and	_	_	_	_	_	_	_	_
105	hypertension	_	_	_	_	_	_	_	_
106	,	_	_	_	_	_	_	_	_
107	may	_	_	_	_	_	_	_	BeginSeg=Yes
108	be	_	_	_	_	_	_	_	_
109	important	_	_	_	_	_	_	_	_
110	risk	_	_	_	_	_	_	_	_
111	factors	_	_	_	_	_	_	_	_
112	for	_	_	_	_	_	_	_	_
113	severe	_	_	_	_	_	_	_	_
114	and	_	_	_	_	_	_	_	_
115	critical	_	_	_	_	_	_	_	_
116	cases	_	_	_	_	_	_	_	_
117	of	_	_	_	_	_	_	_	_
118	infection	_	_	_	_	_	_	_	_
119	,	_	_	_	_	_	_	_	_
120	highlighting	_	_	_	_	_	_	_	BeginSeg=Yes
121	parallels	_	_	_	_	_	_	_	_
122	between	_	_	_	_	_	_	_	_
123	the	_	_	_	_	_	_	_	_
124	pathophysiology	_	_	_	_	_	_	_	_
125	of	_	_	_	_	_	_	_	_
126	these	_	_	_	_	_	_	_	_
127	metabolic	_	_	_	_	_	_	_	_
128	abnormalities	_	_	_	_	_	_	_	_
129	and	_	_	_	_	_	_	_	_
130	the	_	_	_	_	_	_	_	_
131	disease	_	_	_	_	_	_	_	_
132	course	_	_	_	_	_	_	_	_
133	of	_	_	_	_	_	_	_	_
134	COVID-19	_	_	_	_	_	_	_	_
135	.	_	_	_	_	_	_	_	_
136	I	_	_	_	_	_	_	_	BeginSeg=Yes
137	also	_	_	_	_	_	_	_	_
138	discuss	_	_	_	_	_	_	_	_
139	how	_	_	_	_	_	_	_	_
140	metabolism	_	_	_	_	_	_	_	_
141	at	_	_	_	_	_	_	_	_
142	the	_	_	_	_	_	_	_	_
143	cellular	_	_	_	_	_	_	_	_
144	,	_	_	_	_	_	_	_	_
145	tissue	_	_	_	_	_	_	_	_
146	and	_	_	_	_	_	_	_	_
147	organ	_	_	_	_	_	_	_	_
148	levels	_	_	_	_	_	_	_	_
149	might	_	_	_	_	_	_	_	_
150	be	_	_	_	_	_	_	_	_
151	harnessed	_	_	_	_	_	_	_	_
152	to	_	_	_	_	_	_	_	BeginSeg=Yes
153	promote	_	_	_	_	_	_	_	_
154	defence	_	_	_	_	_	_	_	_
155	against	_	_	_	_	_	_	_	_
156	the	_	_	_	_	_	_	_	_
157	infection	_	_	_	_	_	_	_	_
158	,	_	_	_	_	_	_	_	_
159	with	_	_	_	_	_	_	_	BeginSeg=Yes
160	a	_	_	_	_	_	_	_	_
161	focus	_	_	_	_	_	_	_	_
162	on	_	_	_	_	_	_	_	_
163	disease	_	_	_	_	_	_	_	_
164	-	_	_	_	_	_	_	_	_
165	tolerance	_	_	_	_	_	_	_	_
166	mechanisms	_	_	_	_	_	_	_	_
167	,	_	_	_	_	_	_	_	_
168	and	_	_	_	_	_	_	_	BeginSeg=Yes
169	speculate	_	_	_	_	_	_	_	_
170	on	_	_	_	_	_	_	_	_
171	the	_	_	_	_	_	_	_	_
172	long	_	_	_	_	_	_	_	_
173	-	_	_	_	_	_	_	_	_
174	term	_	_	_	_	_	_	_	_
175	metabolic	_	_	_	_	_	_	_	_
176	consequences	_	_	_	_	_	_	_	_
177	for	_	_	_	_	_	_	_	_
178	survivors	_	_	_	_	_	_	_	_
179	of	_	_	_	_	_	_	_	_
180	COVID-19	_	_	_	_	_	_	_	_
181	.	_	_	_	_	_	_	_	_

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2	:	_	_	_	_	_	_	_	_
3	Existing	_	_	_	_	_	_	_	BeginSeg=Yes
4	standard	_	_	_	_	_	_	_	_
5	non	_	_	_	_	_	_	_	_
6	-	_	_	_	_	_	_	_	_
7	molecular	_	_	_	_	_	_	_	_
8	diagnostic	_	_	_	_	_	_	_	_
9	methods	_	_	_	_	_	_	_	_
10	such	_	_	_	_	_	_	_	BeginSeg=Yes
11	as	_	_	_	_	_	_	_	_
12	viral	_	_	_	_	_	_	_	_
13	culture	_	_	_	_	_	_	_	_
14	and	_	_	_	_	_	_	_	_
15	immunofluorescent	_	_	_	_	_	_	_	_
16	(	_	_	_	_	_	_	_	_
17	DFA	_	_	_	_	_	_	_	_
18	)	_	_	_	_	_	_	_	_
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26	or	_	_	_	_	_	_	_	_
27	limited	_	_	_	_	_	_	_	_
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33	assays	_	_	_	_	_	_	_	_
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37	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
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51	diagnosis	_	_	_	_	_	_	_	_
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53	respiratory	_	_	_	_	_	_	_	_
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55	pathogens	_	_	_	_	_	_	_	_
56	.	_	_	_	_	_	_	_	_
57	Methods	_	_	_	_	_	_	_	BeginSeg=Yes
58	:	_	_	_	_	_	_	_	_
59	A	_	_	_	_	_	_	_	BeginSeg=Yes
60	GeXP	_	_	_	_	_	_	_	_
61	-	_	_	_	_	_	_	_	_
62	based	_	_	_	_	_	_	_	_
63	multiplex	_	_	_	_	_	_	_	_
64	RT	_	_	_	_	_	_	_	_
65	-	_	_	_	_	_	_	_	_
66	PCR	_	_	_	_	_	_	_	_
67	assay	_	_	_	_	_	_	_	_
68	(	_	_	_	_	_	_	_	_
69	GeXP	_	_	_	_	_	_	_	_
70	assay	_	_	_	_	_	_	_	_
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75	detect	_	_	_	_	_	_	_	_
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80	virus	_	_	_	_	_	_	_	_
81	types	_	_	_	_	_	_	_	_
82	/	_	_	_	_	_	_	_	_
83	subtypes	_	_	_	_	_	_	_	_
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86	sets	_	_	_	_	_	_	_	_
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90	were	_	_	_	_	_	_	_	_
91	used	_	_	_	_	_	_	_	_
92	to	_	_	_	_	_	_	_	BeginSeg=Yes
93	initiate	_	_	_	_	_	_	_	_
94	the	_	_	_	_	_	_	_	_
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96	-	_	_	_	_	_	_	_	_
97	PCR	_	_	_	_	_	_	_	_
98	,	_	_	_	_	_	_	_	_
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106	used	_	_	_	_	_	_	_	_
107	for	_	_	_	_	_	_	_	_
108	the	_	_	_	_	_	_	_	_
109	subsequent	_	_	_	_	_	_	_	_
110	cycles	_	_	_	_	_	_	_	_
111	of	_	_	_	_	_	_	_	_
112	the	_	_	_	_	_	_	_	_
113	RT	_	_	_	_	_	_	_	_
114	-	_	_	_	_	_	_	_	_
115	PCR	_	_	_	_	_	_	_	_
116	.	_	_	_	_	_	_	_	_
117	The	_	_	_	_	_	_	_	BeginSeg=Yes
118	specificity	_	_	_	_	_	_	_	_
119	of	_	_	_	_	_	_	_	_
120	the	_	_	_	_	_	_	_	_
121	GeXP	_	_	_	_	_	_	_	_
122	assay	_	_	_	_	_	_	_	_
123	was	_	_	_	_	_	_	_	_
124	examined	_	_	_	_	_	_	_	_
125	with	_	_	_	_	_	_	_	_
126	positive	_	_	_	_	_	_	_	_
127	controls	_	_	_	_	_	_	_	_
128	for	_	_	_	_	_	_	_	_
129	each	_	_	_	_	_	_	_	_
130	virus	_	_	_	_	_	_	_	_
131	type	_	_	_	_	_	_	_	_
132	/	_	_	_	_	_	_	_	_
133	subtype	_	_	_	_	_	_	_	_
134	.	_	_	_	_	_	_	_	_
135	The	_	_	_	_	_	_	_	BeginSeg=Yes
136	sensitivity	_	_	_	_	_	_	_	_
137	was	_	_	_	_	_	_	_	_
138	evaluated	_	_	_	_	_	_	_	_
139	by	_	_	_	_	_	_	_	BeginSeg=Yes
140	performing	_	_	_	_	_	_	_	_
141	the	_	_	_	_	_	_	_	_
142	assay	_	_	_	_	_	_	_	_
143	on	_	_	_	_	_	_	_	_
144	serial	_	_	_	_	_	_	_	_
145	ten	_	_	_	_	_	_	_	_
146	-	_	_	_	_	_	_	_	_
147	fold	_	_	_	_	_	_	_	_
148	dilutions	_	_	_	_	_	_	_	_
149	of	_	_	_	_	_	_	_	_
150	in	_	_	_	_	_	_	_	_
151	vitro	_	_	_	_	_	_	_	_
152	-	_	_	_	_	_	_	_	_
153	transcribed	_	_	_	_	_	_	_	_
154	RNA	_	_	_	_	_	_	_	_
155	of	_	_	_	_	_	_	_	_
156	all	_	_	_	_	_	_	_	_
157	RNA	_	_	_	_	_	_	_	_
158	viruses	_	_	_	_	_	_	_	_
159	and	_	_	_	_	_	_	_	_
160	the	_	_	_	_	_	_	_	_
161	plasmids	_	_	_	_	_	_	_	_
162	containing	_	_	_	_	_	_	_	BeginSeg=Yes
163	the	_	_	_	_	_	_	_	_
164	Adv	_	_	_	_	_	_	_	_
165	and	_	_	_	_	_	_	_	_
166	HBoV	_	_	_	_	_	_	_	_
167	target	_	_	_	_	_	_	_	_
168	sequence	_	_	_	_	_	_	_	_
169	.	_	_	_	_	_	_	_	_
170	GeXP	_	_	_	_	_	_	_	BeginSeg=Yes
171	assay	_	_	_	_	_	_	_	_
172	was	_	_	_	_	_	_	_	_
173	further	_	_	_	_	_	_	_	_
174	evaluated	_	_	_	_	_	_	_	_
175	using	_	_	_	_	_	_	_	BeginSeg=Yes
176	126	_	_	_	_	_	_	_	_
177	clinical	_	_	_	_	_	_	_	_
178	specimens	_	_	_	_	_	_	_	_
179	and	_	_	_	_	_	_	_	BeginSeg=Yes
180	compared	_	_	_	_	_	_	_	_
181	with	_	_	_	_	_	_	_	_
182	Luminex	_	_	_	_	_	_	_	_
183	xTAG	_	_	_	_	_	_	_	_
184	RVP	_	_	_	_	_	_	_	_
185	Fast	_	_	_	_	_	_	_	_
186	assay	_	_	_	_	_	_	_	_
187	.	_	_	_	_	_	_	_	_
188	Results	_	_	_	_	_	_	_	BeginSeg=Yes
189	:	_	_	_	_	_	_	_	_
190	The	_	_	_	_	_	_	_	BeginSeg=Yes
191	GeXP	_	_	_	_	_	_	_	_
192	assay	_	_	_	_	_	_	_	_
193	achieved	_	_	_	_	_	_	_	_
194	a	_	_	_	_	_	_	_	_
195	sensitivity	_	_	_	_	_	_	_	_
196	of	_	_	_	_	_	_	_	_
197	20	_	_	_	_	_	_	_	_
198	-	_	_	_	_	_	_	_	_
199	200	_	_	_	_	_	_	_	_
200	copies	_	_	_	_	_	_	_	_
201	for	_	_	_	_	_	_	_	_
202	a	_	_	_	_	_	_	_	_
203	single	_	_	_	_	_	_	_	_
204	virus	_	_	_	_	_	_	_	_
205	and	_	_	_	_	_	_	_	_
206	1000	_	_	_	_	_	_	_	_
207	copies	_	_	_	_	_	_	_	_
208	when	_	_	_	_	_	_	_	BeginSeg=Yes
209	all	_	_	_	_	_	_	_	_
210	of	_	_	_	_	_	_	_	_
211	the	_	_	_	_	_	_	_	_
212	16	_	_	_	_	_	_	_	_
213	pre	_	_	_	_	_	_	_	_
214	-	_	_	_	_	_	_	_	_
215	mixed	_	_	_	_	_	_	_	_
216	viral	_	_	_	_	_	_	_	_
217	targets	_	_	_	_	_	_	_	_
218	were	_	_	_	_	_	_	_	_
219	present	_	_	_	_	_	_	_	_
220	.	_	_	_	_	_	_	_	_
221	Analyses	_	_	_	_	_	_	_	BeginSeg=Yes
222	of	_	_	_	_	_	_	_	_
223	126	_	_	_	_	_	_	_	_
224	clinical	_	_	_	_	_	_	_	_
225	specimens	_	_	_	_	_	_	_	_
226	using	_	_	_	_	_	_	_	BeginSeg=Yes
227	the	_	_	_	_	_	_	_	_
228	GeXP	_	_	_	_	_	_	_	_
229	assay	_	_	_	_	_	_	_	_
230	demonstrated	_	_	_	_	_	_	_	BeginSeg=Yes
231	that	_	_	_	_	_	_	_	BeginSeg=Yes
232	GeXP	_	_	_	_	_	_	_	_
233	assay	_	_	_	_	_	_	_	_
234	and	_	_	_	_	_	_	_	_
235	the	_	_	_	_	_	_	_	_
236	RVP	_	_	_	_	_	_	_	_
237	Fast	_	_	_	_	_	_	_	_
238	assay	_	_	_	_	_	_	_	_
239	were	_	_	_	_	_	_	_	_
240	in	_	_	_	_	_	_	_	_
241	complete	_	_	_	_	_	_	_	_
242	agreement	_	_	_	_	_	_	_	_
243	for	_	_	_	_	_	_	_	_
244	109/126	_	_	_	_	_	_	_	_
245	(	_	_	_	_	_	_	_	_
246	88.51	_	_	_	_	_	_	_	_
247	%	_	_	_	_	_	_	_	_
248	)	_	_	_	_	_	_	_	_
249	of	_	_	_	_	_	_	_	_
250	the	_	_	_	_	_	_	_	_
251	specimens	_	_	_	_	_	_	_	_
252	.	_	_	_	_	_	_	_	_
253	GeXP	_	_	_	_	_	_	_	BeginSeg=Yes
254	assay	_	_	_	_	_	_	_	_
255	was	_	_	_	_	_	_	_	_
256	more	_	_	_	_	_	_	_	_
257	sensitive	_	_	_	_	_	_	_	_
258	than	_	_	_	_	_	_	_	_
259	the	_	_	_	_	_	_	_	_
260	RVP	_	_	_	_	_	_	_	_
261	Fast	_	_	_	_	_	_	_	_
262	assay	_	_	_	_	_	_	_	_
263	for	_	_	_	_	_	_	_	_
264	the	_	_	_	_	_	_	_	_
265	detection	_	_	_	_	_	_	_	_
266	of	_	_	_	_	_	_	_	_
267	HRV	_	_	_	_	_	_	_	_
268	and	_	_	_	_	_	_	_	_
269	PIV3	_	_	_	_	_	_	_	_
270	,	_	_	_	_	_	_	_	_
271	and	_	_	_	_	_	_	_	_
272	slightly	_	_	_	_	_	_	_	_
273	less	_	_	_	_	_	_	_	_
274	sensitive	_	_	_	_	_	_	_	_
275	for	_	_	_	_	_	_	_	_
276	the	_	_	_	_	_	_	_	_
277	detection	_	_	_	_	_	_	_	_
278	of	_	_	_	_	_	_	_	_
279	HMPV	_	_	_	_	_	_	_	_
280	,	_	_	_	_	_	_	_	_
281	Adv	_	_	_	_	_	_	_	_
282	,	_	_	_	_	_	_	_	_
283	RSVB	_	_	_	_	_	_	_	_
284	and	_	_	_	_	_	_	_	_
285	HBoV.	_	_	_	_	_	_	_	_
286	The	_	_	_	_	_	_	_	BeginSeg=Yes
287	whole	_	_	_	_	_	_	_	_
288	process	_	_	_	_	_	_	_	_
289	of	_	_	_	_	_	_	_	_
290	the	_	_	_	_	_	_	_	_
291	GeXP	_	_	_	_	_	_	_	_
292	assay	_	_	_	_	_	_	_	_
293	for	_	_	_	_	_	_	_	_
294	the	_	_	_	_	_	_	_	_
295	detection	_	_	_	_	_	_	_	_
296	of	_	_	_	_	_	_	_	_
297	12	_	_	_	_	_	_	_	_
298	samples	_	_	_	_	_	_	_	_
299	was	_	_	_	_	_	_	_	_
300	completed	_	_	_	_	_	_	_	_
301	within	_	_	_	_	_	_	_	_
302	2.5	_	_	_	_	_	_	_	_
303	hours	_	_	_	_	_	_	_	_
304	.	_	_	_	_	_	_	_	_
305	Conclusions	_	_	_	_	_	_	_	BeginSeg=Yes
306	:	_	_	_	_	_	_	_	_
307	In	_	_	_	_	_	_	_	BeginSeg=Yes
308	conclusion	_	_	_	_	_	_	_	_
309	,	_	_	_	_	_	_	_	_
310	the	_	_	_	_	_	_	_	_
311	GeXP	_	_	_	_	_	_	_	_
312	assay	_	_	_	_	_	_	_	_
313	is	_	_	_	_	_	_	_	_
314	a	_	_	_	_	_	_	_	_
315	rapid	_	_	_	_	_	_	_	_
316	,	_	_	_	_	_	_	_	_
317	cost	_	_	_	_	_	_	_	_
318	-	_	_	_	_	_	_	_	_
319	effective	_	_	_	_	_	_	_	_
320	,	_	_	_	_	_	_	_	_
321	sensitive	_	_	_	_	_	_	_	_
322	,	_	_	_	_	_	_	_	_
323	specific	_	_	_	_	_	_	_	_
324	and	_	_	_	_	_	_	_	_
325	high	_	_	_	_	_	_	_	_
326	throughput	_	_	_	_	_	_	_	_
327	method	_	_	_	_	_	_	_	_
328	for	_	_	_	_	_	_	_	_
329	the	_	_	_	_	_	_	_	_
330	detection	_	_	_	_	_	_	_	_
331	of	_	_	_	_	_	_	_	_
332	respiratory	_	_	_	_	_	_	_	_
333	virus	_	_	_	_	_	_	_	_
334	infections	_	_	_	_	_	_	_	_
335	.	_	_	_	_	_	_	_	_

# newdoc_id = 2a35cb9b73eda5248a85c9d84532b651ab8a3b3a
1	Improved	_	_	_	_	_	_	_	BeginSeg=Yes
2	diagnostic	_	_	_	_	_	_	_	_
3	tools	_	_	_	_	_	_	_	_
4	for	_	_	_	_	_	_	_	_
5	rapid	_	_	_	_	_	_	_	_
6	detection	_	_	_	_	_	_	_	_
7	,	_	_	_	_	_	_	_	_
8	quantitation	_	_	_	_	_	_	_	_
9	,	_	_	_	_	_	_	_	_
10	and	_	_	_	_	_	_	_	_
11	subgrouping	_	_	_	_	_	_	_	_
12	of	_	_	_	_	_	_	_	_
13	human	_	_	_	_	_	_	_	_
14	respiratory	_	_	_	_	_	_	_	_
15	syncytial	_	_	_	_	_	_	_	_
16	virus	_	_	_	_	_	_	_	_
17	(	_	_	_	_	_	_	_	_
18	RSV	_	_	_	_	_	_	_	_
19	)	_	_	_	_	_	_	_	_
20	are	_	_	_	_	_	_	_	_
21	needed	_	_	_	_	_	_	_	_
22	to	_	_	_	_	_	_	_	BeginSeg=Yes
23	aid	_	_	_	_	_	_	_	_
24	the	_	_	_	_	_	_	_	_
25	development	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	evaluation	_	_	_	_	_	_	_	_
28	of	_	_	_	_	_	_	_	_
29	novel	_	_	_	_	_	_	_	_
30	intervention	_	_	_	_	_	_	_	_
31	strategies	_	_	_	_	_	_	_	_
32	.	_	_	_	_	_	_	_	_
33	A	_	_	_	_	_	_	_	BeginSeg=Yes
34	quantitative	_	_	_	_	_	_	_	_
35	real	_	_	_	_	_	_	_	_
36	-	_	_	_	_	_	_	_	_
37	time	_	_	_	_	_	_	_	_
38	RT	_	_	_	_	_	_	_	_
39	-	_	_	_	_	_	_	_	_
40	PCR	_	_	_	_	_	_	_	_
41	using	_	_	_	_	_	_	_	BeginSeg=Yes
42	specific	_	_	_	_	_	_	_	_
43	locked	_	_	_	_	_	_	_	_
44	nucleic	_	_	_	_	_	_	_	_
45	acid	_	_	_	_	_	_	_	_
46	(	_	_	_	_	_	_	_	_
47	LNA	_	_	_	_	_	_	_	_
48	)	_	_	_	_	_	_	_	_
49	probes	_	_	_	_	_	_	_	_
50	was	_	_	_	_	_	_	_	BeginSeg=Yes
51	developed	_	_	_	_	_	_	_	_
52	to	_	_	_	_	_	_	_	BeginSeg=Yes
53	identify	_	_	_	_	_	_	_	_
54	RSV	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	BeginSeg=Yes
56	to	_	_	_	_	_	_	_	_
57	distinguish	_	_	_	_	_	_	_	_
58	RSV	_	_	_	_	_	_	_	_
59	subgroups	_	_	_	_	_	_	_	_
60	A	_	_	_	_	_	_	_	_
61	and	_	_	_	_	_	_	_	_
62	B	_	_	_	_	_	_	_	_
63	(	_	_	_	_	_	_	_	_
64	RSV	_	_	_	_	_	_	_	_
65	LNA	_	_	_	_	_	_	_	_
66	assay	_	_	_	_	_	_	_	_
67	)	_	_	_	_	_	_	_	_
68	.	_	_	_	_	_	_	_	_
69	RSV	_	_	_	_	_	_	_	BeginSeg=Yes
70	subgroup	_	_	_	_	_	_	_	_
71	diversity	_	_	_	_	_	_	_	_
72	and	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	relationship	_	_	_	_	_	_	_	_
75	between	_	_	_	_	_	_	_	_
76	viral	_	_	_	_	_	_	_	_
77	load	_	_	_	_	_	_	_	_
78	and	_	_	_	_	_	_	_	_
79	disease	_	_	_	_	_	_	_	_
80	severity	_	_	_	_	_	_	_	_
81	in	_	_	_	_	_	_	_	_
82	confirmed	_	_	_	_	_	_	_	_
83	RSV	_	_	_	_	_	_	_	_
84	infections	_	_	_	_	_	_	_	_
85	were	_	_	_	_	_	_	_	_
86	also	_	_	_	_	_	_	_	_
87	explored	_	_	_	_	_	_	_	_
88	.	_	_	_	_	_	_	_	_
89	264	_	_	_	_	_	_	_	BeginSeg=Yes
90	archived	_	_	_	_	_	_	_	_
91	respiratory	_	_	_	_	_	_	_	_
92	specimens	_	_	_	_	_	_	_	_
93	from	_	_	_	_	_	_	_	_
94	pediatric	_	_	_	_	_	_	_	_
95	patients	_	_	_	_	_	_	_	_
96	were	_	_	_	_	_	_	_	_
97	tested	_	_	_	_	_	_	_	_
98	in	_	_	_	_	_	_	_	_
99	parallel	_	_	_	_	_	_	_	_
100	using	_	_	_	_	_	_	_	BeginSeg=Yes
101	the	_	_	_	_	_	_	_	_
102	commercial	_	_	_	_	_	_	_	_
103	multiplex	_	_	_	_	_	_	_	_
104	Seeplex	_	_	_	_	_	_	_	_
105	TM	_	_	_	_	_	_	_	_
106	RV	_	_	_	_	_	_	_	_
107	detection	_	_	_	_	_	_	_	_
108	kit	_	_	_	_	_	_	_	_
109	(	_	_	_	_	_	_	_	_
110	Seegene	_	_	_	_	_	_	_	_
111	)	_	_	_	_	_	_	_	_
112	and	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	novel	_	_	_	_	_	_	_	_
115	RSV	_	_	_	_	_	_	_	_
116	LNA	_	_	_	_	_	_	_	_
117	assay	_	_	_	_	_	_	_	_
118	.	_	_	_	_	_	_	_	_
119	The	_	_	_	_	_	_	_	BeginSeg=Yes
120	LNA	_	_	_	_	_	_	_	_
121	assay	_	_	_	_	_	_	_	_
122	demonstrated	_	_	_	_	_	_	_	_
123	a	_	_	_	_	_	_	_	_
124	significantly	_	_	_	_	_	_	_	_
125	higher	_	_	_	_	_	_	_	_
126	sensitivity	_	_	_	_	_	_	_	_
127	than	_	_	_	_	_	_	_	_
128	Seeplex	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	improving	_	_	_	_	_	_	_	BeginSeg=Yes
131	overall	_	_	_	_	_	_	_	_
132	detection	_	_	_	_	_	_	_	_
133	rates	_	_	_	_	_	_	_	_
134	from	_	_	_	_	_	_	_	_
135	24	_	_	_	_	_	_	_	_
136	%	_	_	_	_	_	_	_	_
137	(	_	_	_	_	_	_	_	BeginSeg=Yes
138	64/264	_	_	_	_	_	_	_	_
139	)	_	_	_	_	_	_	_	_
140	to	_	_	_	_	_	_	_	BeginSeg=Yes
141	32	_	_	_	_	_	_	_	_
142	%	_	_	_	_	_	_	_	_
143	(	_	_	_	_	_	_	_	BeginSeg=Yes
144	84/264	_	_	_	_	_	_	_	_
145	)	_	_	_	_	_	_	_	_
146	.	_	_	_	_	_	_	_	_
147	Detection	_	_	_	_	_	_	_	BeginSeg=Yes
148	limits	_	_	_	_	_	_	_	_
149	of	_	_	_	_	_	_	_	_
150	9.0	_	_	_	_	_	_	_	_
151	×	_	_	_	_	_	_	_	_
152	10	_	_	_	_	_	_	_	_
153	1	_	_	_	_	_	_	_	_
154	and	_	_	_	_	_	_	_	_
155	6.0	_	_	_	_	_	_	_	_
156	×	_	_	_	_	_	_	_	_
157	10	_	_	_	_	_	_	_	_
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105	,	_	_	_	_	_	_	_	_
106	lockdown	_	_	_	_	_	_	_	_
107	,	_	_	_	_	_	_	_	_
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109	past	_	_	_	_	_	_	_	_
110	couple	_	_	_	_	_	_	_	_
111	of	_	_	_	_	_	_	_	_
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113	.	_	_	_	_	_	_	_	_
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115	geographically	_	_	_	_	_	_	_	_
116	close	_	_	_	_	_	_	_	_
117	,	_	_	_	_	_	_	_	_
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119	neighboring	_	_	_	_	_	_	_	_
120	countries	_	_	_	_	_	_	_	_
121	reacted	_	_	_	_	_	_	_	_
122	differently	_	_	_	_	_	_	_	_
123	to	_	_	_	_	_	_	_	_
124	one	_	_	_	_	_	_	_	_
125	another	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_
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128	instance	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	Denmark	_	_	_	_	_	_	_	_
131	and	_	_	_	_	_	_	_	_
132	Sweden	_	_	_	_	_	_	_	_
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136	many	_	_	_	_	_	_	_	_
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138	,	_	_	_	_	_	_	_	_
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140	poles	_	_	_	_	_	_	_	_
141	apart	_	_	_	_	_	_	_	_
142	on	_	_	_	_	_	_	_	_
143	the	_	_	_	_	_	_	_	_
144	decision	_	_	_	_	_	_	_	_
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146	by	_	_	_	_	_	_	_	_
147	their	_	_	_	_	_	_	_	_
148	respective	_	_	_	_	_	_	_	_
149	governments	_	_	_	_	_	_	_	_
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154-155	nation's	_	_	_	_	_	_	_	_
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155	's	_	_	_	_	_	_	_	_
156	support	_	_	_	_	_	_	_	_
157	was	_	_	_	_	_	_	_	_
158	mostly	_	_	_	_	_	_	_	_
159	unanimous	_	_	_	_	_	_	_	_
160	,	_	_	_	_	_	_	_	_
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162	the	_	_	_	_	_	_	_	_
163	South	_	_	_	_	_	_	_	_
164	Asian	_	_	_	_	_	_	_	_
165	neighboring	_	_	_	_	_	_	_	_
166	countries	_	_	_	_	_	_	_	_
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174	and	_	_	_	_	_	_	_	_
175	resentment	_	_	_	_	_	_	_	_
176	.	_	_	_	_	_	_	_	_
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179	tends	_	_	_	_	_	_	_	_
180	to	_	_	_	_	_	_	_	_
181	detect	_	_	_	_	_	_	_	_
182	and	_	_	_	_	_	_	_	_
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185	polarity	_	_	_	_	_	_	_	_
186	and	_	_	_	_	_	_	_	_
187	emotions	_	_	_	_	_	_	_	_
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189	during	_	_	_	_	_	_	_	_
190	the	_	_	_	_	_	_	_	_
191	initial	_	_	_	_	_	_	_	_
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202	language	_	_	_	_	_	_	_	_
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204	(	_	_	_	_	_	_	_	_
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206	)	_	_	_	_	_	_	_	_
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210	techniques	_	_	_	_	_	_	_	_
211	on	_	_	_	_	_	_	_	_
212	Twitter	_	_	_	_	_	_	_	_
213	posts	_	_	_	_	_	_	_	_
214	.	_	_	_	_	_	_	_	_
215	Deep	_	_	_	_	_	_	_	BeginSeg=Yes
216	long	_	_	_	_	_	_	_	_
217	short	_	_	_	_	_	_	_	_
218	-	_	_	_	_	_	_	_	_
219	term	_	_	_	_	_	_	_	_
220	memory	_	_	_	_	_	_	_	_
221	(	_	_	_	_	_	_	_	_
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223	)	_	_	_	_	_	_	_	_
224	models	_	_	_	_	_	_	_	_
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227	estimating	_	_	_	_	_	_	_	_
228	the	_	_	_	_	_	_	_	_
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230	polarity	_	_	_	_	_	_	_	_
231	and	_	_	_	_	_	_	_	_
232	emotions	_	_	_	_	_	_	_	_
233	from	_	_	_	_	_	_	_	_
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240	achieve	_	_	_	_	_	_	_	_
241	state	_	_	_	_	_	_	_	_
242	-	_	_	_	_	_	_	_	_
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250	the	_	_	_	_	_	_	_	_
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252	dataset	_	_	_	_	_	_	_	_
253	.	_	_	_	_	_	_	_	_
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255	use	_	_	_	_	_	_	_	_
256	of	_	_	_	_	_	_	_	_
257	emoticons	_	_	_	_	_	_	_	_
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261	and	_	_	_	_	_	_	_	_
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263	way	_	_	_	_	_	_	_	_
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265	validating	_	_	_	_	_	_	_	_
266	the	_	_	_	_	_	_	_	_
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268	deep	_	_	_	_	_	_	_	_
269	learning	_	_	_	_	_	_	_	_
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272	tweets	_	_	_	_	_	_	_	_
273	extracted	_	_	_	_	_	_	_	BeginSeg=Yes
274	from	_	_	_	_	_	_	_	_
275	Twitter	_	_	_	_	_	_	_	_
276	.	_	_	_	_	_	_	_	_

# newdoc_id = 2c08714eb56aedc24e6e4243784ca66870a234c1
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2	of	_	_	_	_	_	_	_	_
3	today	_	_	_	_	_	_	_	_
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27	future	_	_	_	_	_	_	_	_
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30	kinds	_	_	_	_	_	_	_	_
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35	prevail	_	_	_	_	_	_	_	_
36	in	_	_	_	_	_	_	_	_
37	the	_	_	_	_	_	_	_	_
38	society	_	_	_	_	_	_	_	_
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43	generation	_	_	_	_	_	_	_	_
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48	.	_	_	_	_	_	_	_	_
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50	and	_	_	_	_	_	_	_	_
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59	transformation	_	_	_	_	_	_	_	_
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61	be	_	_	_	_	_	_	_	_
62	able	_	_	_	_	_	_	_	_
63	to	_	_	_	_	_	_	_	_
64	meet	_	_	_	_	_	_	_	_
65	the	_	_	_	_	_	_	_	_
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77	COVID-19	_	_	_	_	_	_	_	_
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79	has	_	_	_	_	_	_	_	_
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83	forced	_	_	_	_	_	_	_	_
84	schools	_	_	_	_	_	_	_	_
85	and	_	_	_	_	_	_	_	_
86	education	_	_	_	_	_	_	_	_
87	indeed	_	_	_	_	_	_	_	_
88	to	_	_	_	_	_	_	_	_
89	engage	_	_	_	_	_	_	_	_
90	in	_	_	_	_	_	_	_	_
91	such	_	_	_	_	_	_	_	_
92	a	_	_	_	_	_	_	_	_
93	transformation	_	_	_	_	_	_	_	_
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100	the	_	_	_	_	_	_	_	_
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187	at	_	_	_	_	_	_	_	_
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201	them	_	_	_	_	_	_	_	_
202	with	_	_	_	_	_	_	_	_
203	important	_	_	_	_	_	_	_	_
204	skills	_	_	_	_	_	_	_	_
205	and	_	_	_	_	_	_	_	_
206	competencies	_	_	_	_	_	_	_	_
207	for	_	_	_	_	_	_	_	_
208	their	_	_	_	_	_	_	_	_
209	digital	_	_	_	_	_	_	_	_
210	futures	_	_	_	_	_	_	_	_
211	but	_	_	_	_	_	_	_	BeginSeg=Yes
212	also	_	_	_	_	_	_	_	_
213	for	_	_	_	_	_	_	_	_
214	the	_	_	_	_	_	_	_	_
215	purpose	_	_	_	_	_	_	_	_
216	of	_	_	_	_	_	_	_	_
217	arousing	_	_	_	_	_	_	_	_
218	their	_	_	_	_	_	_	_	_
219	interest	_	_	_	_	_	_	_	_
220	in	_	_	_	_	_	_	_	_
221	this	_	_	_	_	_	_	_	_
222	important	_	_	_	_	_	_	_	_
223	field	_	_	_	_	_	_	_	_
224	,	_	_	_	_	_	_	_	_
225	maybe	_	_	_	_	_	_	_	_
226	even	_	_	_	_	_	_	_	_
227	as	_	_	_	_	_	_	_	_
228	a	_	_	_	_	_	_	_	_
229	career	_	_	_	_	_	_	_	_
230	option	_	_	_	_	_	_	_	_
231	.	_	_	_	_	_	_	_	_

# newdoc_id = 2d0664c3be770994d502f1d1baae42684652aad4
1	Vaccination	_	_	_	_	_	_	_	BeginSeg=Yes
2	is	_	_	_	_	_	_	_	_
3	one	_	_	_	_	_	_	_	_
4	of	_	_	_	_	_	_	_	_
5	the	_	_	_	_	_	_	_	_
6	cheapest	_	_	_	_	_	_	_	_
7	health	_	_	_	_	_	_	_	_
8	-	_	_	_	_	_	_	_	_
9	care	_	_	_	_	_	_	_	_
10	interventions	_	_	_	_	_	_	_	_
11	that	_	_	_	_	_	_	_	BeginSeg=Yes
12	have	_	_	_	_	_	_	_	_
13	saved	_	_	_	_	_	_	_	_
14	more	_	_	_	_	_	_	_	_
15	lives	_	_	_	_	_	_	_	_
16	than	_	_	_	_	_	_	_	_
17	any	_	_	_	_	_	_	_	_
18	other	_	_	_	_	_	_	_	_
19	drugs	_	_	_	_	_	_	_	_
20	or	_	_	_	_	_	_	_	_
21	therapies	_	_	_	_	_	_	_	_
22	.	_	_	_	_	_	_	_	_
23	Due	_	_	_	_	_	_	_	BeginSeg=Yes
24	to	_	_	_	_	_	_	_	_
25	successful	_	_	_	_	_	_	_	_
26	immunization	_	_	_	_	_	_	_	_
27	programs	_	_	_	_	_	_	_	_
28	we	_	_	_	_	_	_	_	BeginSeg=Yes
29	rarely	_	_	_	_	_	_	_	_
30	hear	_	_	_	_	_	_	_	_
31	about	_	_	_	_	_	_	_	_
32	some	_	_	_	_	_	_	_	_
33	of	_	_	_	_	_	_	_	_
34	the	_	_	_	_	_	_	_	_
35	common	_	_	_	_	_	_	_	_
36	diseases	_	_	_	_	_	_	_	_
37	of	_	_	_	_	_	_	_	_
38	the	_	_	_	_	_	_	_	_
39	early	_	_	_	_	_	_	_	_
40	twentieth	_	_	_	_	_	_	_	_
41	century	_	_	_	_	_	_	_	_
42	including	_	_	_	_	_	_	_	BeginSeg=Yes
43	small	_	_	_	_	_	_	_	_
44	pox	_	_	_	_	_	_	_	_
45	and	_	_	_	_	_	_	_	_
46	polio	_	_	_	_	_	_	_	_
47	.	_	_	_	_	_	_	_	_
48	Vaccination	_	_	_	_	_	_	_	BeginSeg=Yes
49	programs	_	_	_	_	_	_	_	_
50	have	_	_	_	_	_	_	_	_
51	also	_	_	_	_	_	_	_	_
52	helped	_	_	_	_	_	_	_	_
53	to	_	_	_	_	_	_	_	_
54	increase	_	_	_	_	_	_	_	_
55	food	_	_	_	_	_	_	_	_
56	production	_	_	_	_	_	_	_	_
57	notably	_	_	_	_	_	_	_	_
58	poultry	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	cattle	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	and	_	_	_	_	_	_	_	_
63	milk	_	_	_	_	_	_	_	_
64	production	_	_	_	_	_	_	_	_
65	due	_	_	_	_	_	_	_	BeginSeg=Yes
66	to	_	_	_	_	_	_	_	_
67	lower	_	_	_	_	_	_	_	_
68	incidence	_	_	_	_	_	_	_	_
69	of	_	_	_	_	_	_	_	_
70	infectious	_	_	_	_	_	_	_	_
71	diseases	_	_	_	_	_	_	_	_
72	in	_	_	_	_	_	_	_	_
73	farm	_	_	_	_	_	_	_	_
74	animals	_	_	_	_	_	_	_	_
75	.	_	_	_	_	_	_	_	_
76	Though	_	_	_	_	_	_	_	BeginSeg=Yes
77	vaccination	_	_	_	_	_	_	_	_
78	programs	_	_	_	_	_	_	_	_
79	have	_	_	_	_	_	_	_	_
80	eradicated	_	_	_	_	_	_	_	_
81	several	_	_	_	_	_	_	_	_
82	diseases	_	_	_	_	_	_	_	_
83	and	_	_	_	_	_	_	_	BeginSeg=Yes
84	increased	_	_	_	_	_	_	_	_
85	the	_	_	_	_	_	_	_	_
86	quality	_	_	_	_	_	_	_	_
87	of	_	_	_	_	_	_	_	_
88	life	_	_	_	_	_	_	_	_
89	there	_	_	_	_	_	_	_	BeginSeg=Yes
90	are	_	_	_	_	_	_	_	_
91	several	_	_	_	_	_	_	_	_
92	diseases	_	_	_	_	_	_	_	_
93	that	_	_	_	_	_	_	_	_
94	have	_	_	_	_	_	_	_	_
95	no	_	_	_	_	_	_	_	_
96	effective	_	_	_	_	_	_	_	_
97	vaccines	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	Currently	_	_	_	_	_	_	_	BeginSeg=Yes
100	there	_	_	_	_	_	_	_	_
101	are	_	_	_	_	_	_	_	_
102	no	_	_	_	_	_	_	_	_
103	vaccines	_	_	_	_	_	_	_	_
104	for	_	_	_	_	_	_	_	_
105	cancer	_	_	_	_	_	_	_	_
106	,	_	_	_	_	_	_	_	_
107	neurodegenerative	_	_	_	_	_	_	_	_
108	diseases	_	_	_	_	_	_	_	_
109	,	_	_	_	_	_	_	_	_
110	autoimmune	_	_	_	_	_	_	_	_
111	diseases	_	_	_	_	_	_	_	_
112	,	_	_	_	_	_	_	_	_
113	as	_	_	_	_	_	_	_	_
114	well	_	_	_	_	_	_	_	_
115	as	_	_	_	_	_	_	_	_
116	infectious	_	_	_	_	_	_	_	_
117	diseases	_	_	_	_	_	_	_	_
118	like	_	_	_	_	_	_	_	_
119	tuberculosis	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	AIDS	_	_	_	_	_	_	_	_
122	,	_	_	_	_	_	_	_	_
123	and	_	_	_	_	_	_	_	_
124	parasitic	_	_	_	_	_	_	_	_
125	diseases	_	_	_	_	_	_	_	_
126	including	_	_	_	_	_	_	_	BeginSeg=Yes
127	malaria	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	Abuse	_	_	_	_	_	_	_	BeginSeg=Yes
130	of	_	_	_	_	_	_	_	_
131	antibiotics	_	_	_	_	_	_	_	_
132	has	_	_	_	_	_	_	_	_
133	resulted	_	_	_	_	_	_	_	_
134	in	_	_	_	_	_	_	_	_
135	the	_	_	_	_	_	_	_	_
136	generation	_	_	_	_	_	_	_	_
137	of	_	_	_	_	_	_	_	_
138	several	_	_	_	_	_	_	_	_
139	antibiotic	_	_	_	_	_	_	_	_
140	-	_	_	_	_	_	_	_	_
141	resistant	_	_	_	_	_	_	_	_
142	bacterial	_	_	_	_	_	_	_	_
143	strains	_	_	_	_	_	_	_	_
144	;	_	_	_	_	_	_	_	_
145	hence	_	_	_	_	_	_	_	BeginSeg=Yes
146	there	_	_	_	_	_	_	_	_
147	is	_	_	_	_	_	_	_	_
148	a	_	_	_	_	_	_	_	_
149	need	_	_	_	_	_	_	_	_
150	to	_	_	_	_	_	_	_	_
151	develop	_	_	_	_	_	_	_	_
152	novel	_	_	_	_	_	_	_	_
153	vaccines	_	_	_	_	_	_	_	_
154	for	_	_	_	_	_	_	_	_
155	antibiotic	_	_	_	_	_	_	_	_
156	-	_	_	_	_	_	_	_	_
157	resistant	_	_	_	_	_	_	_	_
158	microorganisms	_	_	_	_	_	_	_	_
159	.	_	_	_	_	_	_	_	_
160	Changes	_	_	_	_	_	_	_	BeginSeg=Yes
161	in	_	_	_	_	_	_	_	_
162	climate	_	_	_	_	_	_	_	_
163	is	_	_	_	_	_	_	_	_
164	another	_	_	_	_	_	_	_	_
165	concern	_	_	_	_	_	_	_	_
166	for	_	_	_	_	_	_	_	_
167	vaccinologists	_	_	_	_	_	_	_	_
168	.	_	_	_	_	_	_	_	_
169	Climate	_	_	_	_	_	_	_	BeginSeg=Yes
170	change	_	_	_	_	_	_	_	_
171	could	_	_	_	_	_	_	_	_
172	lead	_	_	_	_	_	_	_	_
173	to	_	_	_	_	_	_	_	_
174	generation	_	_	_	_	_	_	_	_
175	of	_	_	_	_	_	_	_	_
176	new	_	_	_	_	_	_	_	_
177	strains	_	_	_	_	_	_	_	_
178	of	_	_	_	_	_	_	_	_
179	infectious	_	_	_	_	_	_	_	_
180	microorganisms	_	_	_	_	_	_	_	_
181	that	_	_	_	_	_	_	_	BeginSeg=Yes
182	would	_	_	_	_	_	_	_	_
183	require	_	_	_	_	_	_	_	_
184	development	_	_	_	_	_	_	_	_
185	of	_	_	_	_	_	_	_	_
186	novel	_	_	_	_	_	_	_	_
187	vaccines	_	_	_	_	_	_	_	_
188	.	_	_	_	_	_	_	_	_
189	Use	_	_	_	_	_	_	_	BeginSeg=Yes
190	of	_	_	_	_	_	_	_	_
191	conventional	_	_	_	_	_	_	_	_
192	vaccination	_	_	_	_	_	_	_	_
193	strategies	_	_	_	_	_	_	_	_
194	to	_	_	_	_	_	_	_	BeginSeg=Yes
195	develop	_	_	_	_	_	_	_	_
196	vaccines	_	_	_	_	_	_	_	_
197	has	_	_	_	_	_	_	_	BeginSeg=Yes
198	severe	_	_	_	_	_	_	_	_
199	limitations	_	_	_	_	_	_	_	_
200	;	_	_	_	_	_	_	_	_
201	hence	_	_	_	_	_	_	_	BeginSeg=Yes
202	innovative	_	_	_	_	_	_	_	_
203	strategies	_	_	_	_	_	_	_	_
204	are	_	_	_	_	_	_	_	_
205	essential	_	_	_	_	_	_	_	_
206	in	_	_	_	_	_	_	_	_
207	the	_	_	_	_	_	_	_	_
208	development	_	_	_	_	_	_	_	_
209	of	_	_	_	_	_	_	_	_
210	novel	_	_	_	_	_	_	_	_
211	and	_	_	_	_	_	_	_	_
212	effective	_	_	_	_	_	_	_	_
213	vaccines	_	_	_	_	_	_	_	_
214	.	_	_	_	_	_	_	_	_

# newdoc_id = 2d9482a26d740c255bf3108d1c628e97fae3cc7a
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	canine	_	_	_	_	_	_	_	_
3	respiratory	_	_	_	_	_	_	_	_
4	coronavirus	_	_	_	_	_	_	_	_
5	(	_	_	_	_	_	_	_	_
6	CRCoV	_	_	_	_	_	_	_	_
7	)	_	_	_	_	_	_	_	_
8	K37	_	_	_	_	_	_	_	_
9	strain	_	_	_	_	_	_	_	_
10	of	_	_	_	_	_	_	_	_
11	the	_	_	_	_	_	_	_	_
12	family	_	_	_	_	_	_	_	_
13	Coronaviridae	_	_	_	_	_	_	_	_
14	,	_	_	_	_	_	_	_	_
15	group	_	_	_	_	_	_	_	_
16	2	_	_	_	_	_	_	_	_
17	,	_	_	_	_	_	_	_	_
18	was	_	_	_	_	_	_	_	_
19	isolated	_	_	_	_	_	_	_	_
20	in	_	_	_	_	_	_	_	_
21	South	_	_	_	_	_	_	_	_
22	Korea	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
24	Its	_	_	_	_	_	_	_	BeginSeg=Yes
25	genome	_	_	_	_	_	_	_	_
26	was	_	_	_	_	_	_	_	_
27	analyzed	_	_	_	_	_	_	_	_
28	by	_	_	_	_	_	_	_	_
29	nucleotide	_	_	_	_	_	_	_	_
30	sequencing	_	_	_	_	_	_	_	_
31	and	_	_	_	_	_	_	_	BeginSeg=Yes
32	was	_	_	_	_	_	_	_	_
33	determined	_	_	_	_	_	_	_	_
34	to	_	_	_	_	_	_	_	_
35	have	_	_	_	_	_	_	_	_
36	31,029	_	_	_	_	_	_	_	_
37	bp	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
39	The	_	_	_	_	_	_	_	BeginSeg=Yes
40	small	_	_	_	_	_	_	_	_
41	open	_	_	_	_	_	_	_	_
42	reading	_	_	_	_	_	_	_	_
43	frames	_	_	_	_	_	_	_	_
44	situated	_	_	_	_	_	_	_	BeginSeg=Yes
45	between	_	_	_	_	_	_	_	_
46	the	_	_	_	_	_	_	_	_
47	spike	_	_	_	_	_	_	_	_
48	and	_	_	_	_	_	_	_	_
49	envelope	_	_	_	_	_	_	_	_
50	genes	_	_	_	_	_	_	_	_
51	of	_	_	_	_	_	_	_	_
52	most	_	_	_	_	_	_	_	_
53	of	_	_	_	_	_	_	_	_
54	the	_	_	_	_	_	_	_	_
55	CRCoV	_	_	_	_	_	_	_	_
56	strains	_	_	_	_	_	_	_	_
57	(	_	_	_	_	_	_	_	BeginSeg=Yes
58	except	_	_	_	_	_	_	_	_
59	the	_	_	_	_	_	_	_	_
60	CRCoV	_	_	_	_	_	_	_	_
61	4180	_	_	_	_	_	_	_	_
62	strain	_	_	_	_	_	_	_	_
63	)	_	_	_	_	_	_	_	_
64	were	_	_	_	_	_	_	_	BeginSeg=Yes
65	found	_	_	_	_	_	_	_	_
66	to	_	_	_	_	_	_	_	_
67	encode	_	_	_	_	_	_	_	_
68	three	_	_	_	_	_	_	_	_
69	nonstructural	_	_	_	_	_	_	_	_
70	proteins	_	_	_	_	_	_	_	_
71	(	_	_	_	_	_	_	_	BeginSeg=Yes
72	4.9	_	_	_	_	_	_	_	_
73	kDa	_	_	_	_	_	_	_	_
74	,	_	_	_	_	_	_	_	_
75	2.7	_	_	_	_	_	_	_	_
76	kDa	_	_	_	_	_	_	_	_
77	,	_	_	_	_	_	_	_	_
78	and	_	_	_	_	_	_	_	_
79	12.8	_	_	_	_	_	_	_	_
80	kDa	_	_	_	_	_	_	_	_
81	)	_	_	_	_	_	_	_	_
82	,	_	_	_	_	_	_	_	_
83	while	_	_	_	_	_	_	_	BeginSeg=Yes
84	those	_	_	_	_	_	_	_	_
85	of	_	_	_	_	_	_	_	_
86	bovine	_	_	_	_	_	_	_	_
87	coronavirus	_	_	_	_	_	_	_	_
88	(	_	_	_	_	_	_	_	_
89	BCoV	_	_	_	_	_	_	_	_
90	)	_	_	_	_	_	_	_	_
91	encode	_	_	_	_	_	_	_	_
92	another	_	_	_	_	_	_	_	_
93	three	_	_	_	_	_	_	_	_
94	nonstructural	_	_	_	_	_	_	_	_
95	proteins	_	_	_	_	_	_	_	_
96	(	_	_	_	_	_	_	_	BeginSeg=Yes
97	4.9	_	_	_	_	_	_	_	_
98	kDa	_	_	_	_	_	_	_	_
99	,	_	_	_	_	_	_	_	_
100	4.8	_	_	_	_	_	_	_	_
101	kDa	_	_	_	_	_	_	_	_
102	,	_	_	_	_	_	_	_	_
103	and	_	_	_	_	_	_	_	_
104	12.7	_	_	_	_	_	_	_	_
105	kDa	_	_	_	_	_	_	_	_
106	)	_	_	_	_	_	_	_	_
107	and	_	_	_	_	_	_	_	BeginSeg=Yes
108	those	_	_	_	_	_	_	_	_
109	of	_	_	_	_	_	_	_	_
110	a	_	_	_	_	_	_	_	_
111	recently	_	_	_	_	_	_	_	_
112	isolated	_	_	_	_	_	_	_	_
113	bovine	_	_	_	_	_	_	_	_
114	respiratory	_	_	_	_	_	_	_	_
115	coronavirus	_	_	_	_	_	_	_	_
116	(	_	_	_	_	_	_	_	_
117	BRCoV	_	_	_	_	_	_	_	_
118	)	_	_	_	_	_	_	_	_
119	were	_	_	_	_	_	_	_	_
120	found	_	_	_	_	_	_	_	_
121	to	_	_	_	_	_	_	_	_
122	encode	_	_	_	_	_	_	_	_
123	only	_	_	_	_	_	_	_	_
124	two	_	_	_	_	_	_	_	_
125	nonstructural	_	_	_	_	_	_	_	_
126	proteins	_	_	_	_	_	_	_	_
127	(	_	_	_	_	_	_	_	BeginSeg=Yes
128	4.9	_	_	_	_	_	_	_	_
129	kDa	_	_	_	_	_	_	_	_
130	and	_	_	_	_	_	_	_	_
131	12.7	_	_	_	_	_	_	_	_
132	kDa	_	_	_	_	_	_	_	_
133	)	_	_	_	_	_	_	_	_
134	.	_	_	_	_	_	_	_	_
135	The	_	_	_	_	_	_	_	BeginSeg=Yes
136	differences	_	_	_	_	_	_	_	_
137	in	_	_	_	_	_	_	_	_
138	the	_	_	_	_	_	_	_	_
139	genes	_	_	_	_	_	_	_	_
140	encoding	_	_	_	_	_	_	_	BeginSeg=Yes
141	these	_	_	_	_	_	_	_	_
142	small	_	_	_	_	_	_	_	_
143	nonstructural	_	_	_	_	_	_	_	_
144	proteins	_	_	_	_	_	_	_	_
145	may	_	_	_	_	_	_	_	BeginSeg=Yes
146	be	_	_	_	_	_	_	_	_
147	associated	_	_	_	_	_	_	_	_
148	with	_	_	_	_	_	_	_	_
149	the	_	_	_	_	_	_	_	_
150	emergence	_	_	_	_	_	_	_	_
151	of	_	_	_	_	_	_	_	_
152	highly	_	_	_	_	_	_	_	_
153	similar	_	_	_	_	_	_	_	_
154	viruses	_	_	_	_	_	_	_	_
155	in	_	_	_	_	_	_	_	_
156	different	_	_	_	_	_	_	_	_
157	hosts	_	_	_	_	_	_	_	_
158	.	_	_	_	_	_	_	_	_

# newdoc_id = 2dd56fdde263e4c8b6a2e54123a89b858a1ecf46
1	Human	_	_	_	_	_	_	_	BeginSeg=Yes
2	coronavirus	_	_	_	_	_	_	_	_
3	HKU1	_	_	_	_	_	_	_	_
4	(	_	_	_	_	_	_	_	_
5	HCoV	_	_	_	_	_	_	_	_
6	-	_	_	_	_	_	_	_	_
7	HKU1	_	_	_	_	_	_	_	_
8	)	_	_	_	_	_	_	_	_
9	,	_	_	_	_	_	_	_	_
10	which	_	_	_	_	_	_	_	BeginSeg=Yes
11	mainly	_	_	_	_	_	_	_	_
12	causes	_	_	_	_	_	_	_	_
13	acute	_	_	_	_	_	_	_	_
14	selflimited	_	_	_	_	_	_	_	_
15	respiratory	_	_	_	_	_	_	_	_
16	-	_	_	_	_	_	_	_	_
17	tract	_	_	_	_	_	_	_	_
18	infections	_	_	_	_	_	_	_	_
19	,	_	_	_	_	_	_	_	_
20	belongs	_	_	_	_	_	_	_	BeginSeg=Yes
21	to	_	_	_	_	_	_	_	_
22	group	_	_	_	_	_	_	_	_
23	A	_	_	_	_	_	_	_	_
24	of	_	_	_	_	_	_	_	_
25	the	_	_	_	_	_	_	_	_
26	Betacoronavirus	_	_	_	_	_	_	_	_
27	genus	_	_	_	_	_	_	_	_
28	.	_	_	_	_	_	_	_	_
29	Coronavirus	_	_	_	_	_	_	_	BeginSeg=Yes
30	genomes	_	_	_	_	_	_	_	_
31	encode	_	_	_	_	_	_	_	_
32	16	_	_	_	_	_	_	_	_
33	nonstructural	_	_	_	_	_	_	_	_
34	proteins	_	_	_	_	_	_	_	_
35	(	_	_	_	_	_	_	_	_
36	nsp1	_	_	_	_	_	_	_	_
37	-	_	_	_	_	_	_	_	_
38	16	_	_	_	_	_	_	_	_
39	)	_	_	_	_	_	_	_	_
40	,	_	_	_	_	_	_	_	_
41	which	_	_	_	_	_	_	_	BeginSeg=Yes
42	assemble	_	_	_	_	_	_	_	_
43	into	_	_	_	_	_	_	_	_
44	a	_	_	_	_	_	_	_	_
45	large	_	_	_	_	_	_	_	_
46	replication	_	_	_	_	_	_	_	_
47	-	_	_	_	_	_	_	_	_
48	transcription	_	_	_	_	_	_	_	_
49	complex	_	_	_	_	_	_	_	_
50	mediating	_	_	_	_	_	_	_	_
51	virus	_	_	_	_	_	_	_	_
52	propagation	_	_	_	_	_	_	_	_
53	.	_	_	_	_	_	_	_	_
54	Nonstructural	_	_	_	_	_	_	_	BeginSeg=Yes
55	protein	_	_	_	_	_	_	_	_
56	9	_	_	_	_	_	_	_	_
57	,	_	_	_	_	_	_	_	_
58	which	_	_	_	_	_	_	_	BeginSeg=Yes
59	binds	_	_	_	_	_	_	_	_
60	to	_	_	_	_	_	_	_	_
61	the	_	_	_	_	_	_	_	_
62	single	_	_	_	_	_	_	_	_
63	-	_	_	_	_	_	_	_	_
64	stranded	_	_	_	_	_	_	_	_
65	DNA	_	_	_	_	_	_	_	_
66	/	_	_	_	_	_	_	_	_
67	RNA	_	_	_	_	_	_	_	_
68	,	_	_	_	_	_	_	_	_
69	has	_	_	_	_	_	_	_	BeginSeg=Yes
70	been	_	_	_	_	_	_	_	_
71	shown	_	_	_	_	_	_	_	_
72	to	_	_	_	_	_	_	_	_
73	be	_	_	_	_	_	_	_	_
74	indispensible	_	_	_	_	_	_	_	_
75	for	_	_	_	_	_	_	_	_
76	viral	_	_	_	_	_	_	_	_
77	replication	_	_	_	_	_	_	_	_
78	.	_	_	_	_	_	_	_	_
79	Interestingly	_	_	_	_	_	_	_	BeginSeg=Yes
80	,	_	_	_	_	_	_	_	_
81	a	_	_	_	_	_	_	_	_
82	functional	_	_	_	_	_	_	_	_
83	mutant	_	_	_	_	_	_	_	_
84	(	_	_	_	_	_	_	_	BeginSeg=Yes
85	N60	_	_	_	_	_	_	_	_
86	K	_	_	_	_	_	_	_	_
87	)	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	BeginSeg=Yes
89	nsp9	_	_	_	_	_	_	_	_
90	was	_	_	_	_	_	_	_	_
91	identified	_	_	_	_	_	_	_	_
92	to	_	_	_	_	_	_	_	_
93	compensate	_	_	_	_	_	_	_	_
94	for	_	_	_	_	_	_	_	_
95	a	_	_	_	_	_	_	_	_
96	6	_	_	_	_	_	_	_	_
97	nt	_	_	_	_	_	_	_	_
98	insertion	_	_	_	_	_	_	_	_
99	mutation	_	_	_	_	_	_	_	_
100	of	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	3	_	_	_	_	_	_	_	_
103	0	_	_	_	_	_	_	_	_
104	-untranslated	_	_	_	_	_	_	_	_
105	region	_	_	_	_	_	_	_	_
106	(	_	_	_	_	_	_	_	_
107	UTR	_	_	_	_	_	_	_	_
108	)	_	_	_	_	_	_	_	_
109	,	_	_	_	_	_	_	_	_
110	which	_	_	_	_	_	_	_	BeginSeg=Yes
111	is	_	_	_	_	_	_	_	_
112	critical	_	_	_	_	_	_	_	_
113	for	_	_	_	_	_	_	_	_
114	viral	_	_	_	_	_	_	_	_
115	RNA	_	_	_	_	_	_	_	_
116	synthesis	_	_	_	_	_	_	_	_
117	.	_	_	_	_	_	_	_	_
118	It	_	_	_	_	_	_	_	BeginSeg=Yes
119	has	_	_	_	_	_	_	_	_
120	been	_	_	_	_	_	_	_	_
121	proposed	_	_	_	_	_	_	_	_
122	that	_	_	_	_	_	_	_	_
123	the	_	_	_	_	_	_	_	_
124	N60	_	_	_	_	_	_	_	_
125	K	_	_	_	_	_	_	_	_
126	mutation	_	_	_	_	_	_	_	_
127	may	_	_	_	_	_	_	_	_
128	cause	_	_	_	_	_	_	_	_
129	certain	_	_	_	_	_	_	_	_
130	conformational	_	_	_	_	_	_	_	_
131	changes	_	_	_	_	_	_	_	_
132	of	_	_	_	_	_	_	_	_
133	nsp9	_	_	_	_	_	_	_	_
134	to	_	_	_	_	_	_	_	BeginSeg=Yes
135	rescue	_	_	_	_	_	_	_	_
136	the	_	_	_	_	_	_	_	_
137	defective	_	_	_	_	_	_	_	_
138	insertion	_	_	_	_	_	_	_	_
139	mutant	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	To	_	_	_	_	_	_	_	BeginSeg=Yes
142	further	_	_	_	_	_	_	_	_
143	investigate	_	_	_	_	_	_	_	_
144	the	_	_	_	_	_	_	_	_
145	underlying	_	_	_	_	_	_	_	_
146	structural	_	_	_	_	_	_	_	_
147	mechanism	_	_	_	_	_	_	_	_
148	,	_	_	_	_	_	_	_	_
149	the	_	_	_	_	_	_	_	BeginSeg=Yes
150	N60	_	_	_	_	_	_	_	_
151	K	_	_	_	_	_	_	_	_
152	mutant	_	_	_	_	_	_	_	_
153	of	_	_	_	_	_	_	_	_
154	nsp9	_	_	_	_	_	_	_	_
155	from	_	_	_	_	_	_	_	_
156	HCoV	_	_	_	_	_	_	_	_
157	-	_	_	_	_	_	_	_	_
158	HKU1	_	_	_	_	_	_	_	_
159	was	_	_	_	_	_	_	_	_
160	successfully	_	_	_	_	_	_	_	_
161	crystallized	_	_	_	_	_	_	_	_
162	in	_	_	_	_	_	_	_	_
163	this	_	_	_	_	_	_	_	_
164	study	_	_	_	_	_	_	_	_
165	.	_	_	_	_	_	_	_	_
166	The	_	_	_	_	_	_	_	BeginSeg=Yes
167	crystals	_	_	_	_	_	_	_	_
168	diffracted	_	_	_	_	_	_	_	_
169	to	_	_	_	_	_	_	_	_
170	2.6	_	_	_	_	_	_	_	_
171	Å	_	_	_	_	_	_	_	_
172	resolution	_	_	_	_	_	_	_	_
173	and	_	_	_	_	_	_	_	BeginSeg=Yes
174	belonged	_	_	_	_	_	_	_	_
175	to	_	_	_	_	_	_	_	_
176	space	_	_	_	_	_	_	_	_
177	group	_	_	_	_	_	_	_	_
178	P2	_	_	_	_	_	_	_	_
179	1	_	_	_	_	_	_	_	_
180	2	_	_	_	_	_	_	_	_
181	1	_	_	_	_	_	_	_	_
182	2	_	_	_	_	_	_	_	_
183	1	_	_	_	_	_	_	_	_
184	,	_	_	_	_	_	_	_	_
185	with	_	_	_	_	_	_	_	_
186	unit	_	_	_	_	_	_	_	_
187	-	_	_	_	_	_	_	_	_
188	cell	_	_	_	_	_	_	_	_
189	parameters	_	_	_	_	_	_	_	_
190	a	_	_	_	_	_	_	_	_
191	=	_	_	_	_	_	_	_	_
192	31.9	_	_	_	_	_	_	_	_
193	,	_	_	_	_	_	_	_	_
194	b	_	_	_	_	_	_	_	_
195	=	_	_	_	_	_	_	_	_
196	85.0	_	_	_	_	_	_	_	_
197	,	_	_	_	_	_	_	_	_
198	c	_	_	_	_	_	_	_	_
199	=	_	_	_	_	_	_	_	_
200	95.0	_	_	_	_	_	_	_	_
201	Å	_	_	_	_	_	_	_	_
202	.	_	_	_	_	_	_	_	_
203	Two	_	_	_	_	_	_	_	BeginSeg=Yes
204	molecules	_	_	_	_	_	_	_	_
205	were	_	_	_	_	_	_	_	_
206	identified	_	_	_	_	_	_	_	_
207	per	_	_	_	_	_	_	_	_
208	asymmetric	_	_	_	_	_	_	_	_
209	unit	_	_	_	_	_	_	_	_
210	.	_	_	_	_	_	_	_	_

# newdoc_id = 2dfa1f27d87881bc93d1521011a48c234f500113
1	Background	_	_	_	_	_	_	_	BeginSeg=Yes
2	The	_	_	_	_	_	_	_	BeginSeg=Yes
3	objectives	_	_	_	_	_	_	_	_
4	of	_	_	_	_	_	_	_	_
5	this	_	_	_	_	_	_	_	_
6	study	_	_	_	_	_	_	_	_
7	were	_	_	_	_	_	_	_	_
8	to	_	_	_	_	_	_	_	_
9	analyze	_	_	_	_	_	_	_	_
10	the	_	_	_	_	_	_	_	_
11	clinical	_	_	_	_	_	_	_	_
12	features	_	_	_	_	_	_	_	_
13	of	_	_	_	_	_	_	_	_
14	coronavirus	_	_	_	_	_	_	_	_
15	disease	_	_	_	_	_	_	_	_
16	2019	_	_	_	_	_	_	_	_
17	and	_	_	_	_	_	_	_	BeginSeg=Yes
18	evaluate	_	_	_	_	_	_	_	_
19	the	_	_	_	_	_	_	_	_
20	diagnosis	_	_	_	_	_	_	_	_
21	and	_	_	_	_	_	_	_	_
22	treatment	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
24	Methods	_	_	_	_	_	_	_	BeginSeg=Yes
25	A	_	_	_	_	_	_	_	BeginSeg=Yes
26	retrospective	_	_	_	_	_	_	_	_
27	analysis	_	_	_	_	_	_	_	_
28	of	_	_	_	_	_	_	_	_
29	the	_	_	_	_	_	_	_	_
30	clinical	_	_	_	_	_	_	_	_
31	manifestation	_	_	_	_	_	_	_	_
32	and	_	_	_	_	_	_	_	_
33	auxiliary	_	_	_	_	_	_	_	_
34	examination	_	_	_	_	_	_	_	_
35	of	_	_	_	_	_	_	_	_
36	19	_	_	_	_	_	_	_	_
37	patients	_	_	_	_	_	_	_	_
38	with	_	_	_	_	_	_	_	_
39	COVID-19	_	_	_	_	_	_	_	_
40	from	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	_
42	Liyuan	_	_	_	_	_	_	_	_
43	Hospital	_	_	_	_	_	_	_	_
44	intensive	_	_	_	_	_	_	_	_
45	care	_	_	_	_	_	_	_	_
46	unit	_	_	_	_	_	_	_	_
47	(	_	_	_	_	_	_	_	_
48	ICU	_	_	_	_	_	_	_	_
49	)	_	_	_	_	_	_	_	_
50	between	_	_	_	_	_	_	_	_
51	January	_	_	_	_	_	_	_	_
52	16	_	_	_	_	_	_	_	_
53	,	_	_	_	_	_	_	_	_
54	2020	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	_
56	February	_	_	_	_	_	_	_	_
57	20	_	_	_	_	_	_	_	_
58	,	_	_	_	_	_	_	_	_
59	2020	_	_	_	_	_	_	_	_
60	was	_	_	_	_	_	_	_	_
61	undertaken	_	_	_	_	_	_	_	_
62	.	_	_	_	_	_	_	_	_
63	Results	_	_	_	_	_	_	_	BeginSeg=Yes
64	There	_	_	_	_	_	_	_	BeginSeg=Yes
65	were	_	_	_	_	_	_	_	_
66	11	_	_	_	_	_	_	_	_
67	male	_	_	_	_	_	_	_	_
68	and	_	_	_	_	_	_	_	_
69	8	_	_	_	_	_	_	_	_
70	female	_	_	_	_	_	_	_	_
71	cases	_	_	_	_	_	_	_	_
72	among	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	patients	_	_	_	_	_	_	_	_
75	.	_	_	_	_	_	_	_	_
76	The	_	_	_	_	_	_	_	BeginSeg=Yes
77	median	_	_	_	_	_	_	_	_
78	(	_	_	_	_	_	_	_	_
79	range	_	_	_	_	_	_	_	_
80	)	_	_	_	_	_	_	_	_
81	age	_	_	_	_	_	_	_	_
82	was	_	_	_	_	_	_	_	_
83	73	_	_	_	_	_	_	_	_
84	(	_	_	_	_	_	_	_	BeginSeg=Yes
85	38	_	_	_	_	_	_	_	_
86	-	_	_	_	_	_	_	_	_
87	91	_	_	_	_	_	_	_	_
88	)	_	_	_	_	_	_	_	_
89	years	_	_	_	_	_	_	_	BeginSeg=Yes
90	.	_	_	_	_	_	_	_	_
91	Of	_	_	_	_	_	_	_	BeginSeg=Yes
92	these	_	_	_	_	_	_	_	_
93	patients	_	_	_	_	_	_	_	_
94	,	_	_	_	_	_	_	_	_
95	8	_	_	_	_	_	_	_	_
96	(	_	_	_	_	_	_	_	BeginSeg=Yes
97	42.1	_	_	_	_	_	_	_	_
98	%	_	_	_	_	_	_	_	_
99	)	_	_	_	_	_	_	_	_
100	had	_	_	_	_	_	_	_	BeginSeg=Yes
101	died	_	_	_	_	_	_	_	_
102	and	_	_	_	_	_	_	_	BeginSeg=Yes
103	the	_	_	_	_	_	_	_	_
104	median	_	_	_	_	_	_	_	_
105	duration	_	_	_	_	_	_	_	_
106	from	_	_	_	_	_	_	_	_
107	ICU	_	_	_	_	_	_	_	_
108	admission	_	_	_	_	_	_	_	_
109	to	_	_	_	_	_	_	_	_
110	death	_	_	_	_	_	_	_	_
111	was	_	_	_	_	_	_	_	_
112	2	_	_	_	_	_	_	_	_
113	(	_	_	_	_	_	_	_	BeginSeg=Yes
114	interquartile	_	_	_	_	_	_	_	_
115	range	_	_	_	_	_	_	_	_
116	(	_	_	_	_	_	_	_	_
117	IQR	_	_	_	_	_	_	_	_
118	)	_	_	_	_	_	_	_	_
119	:	_	_	_	_	_	_	_	_
120	1	_	_	_	_	_	_	_	_
121	-	_	_	_	_	_	_	_	_
122	10.75	_	_	_	_	_	_	_	_
123	)	_	_	_	_	_	_	_	_
124	days	_	_	_	_	_	_	_	BeginSeg=Yes
125	.	_	_	_	_	_	_	_	_
126	Seven	_	_	_	_	_	_	_	BeginSeg=Yes
127	of	_	_	_	_	_	_	_	_
128	these	_	_	_	_	_	_	_	_
129	8	_	_	_	_	_	_	_	_
130	patients	_	_	_	_	_	_	_	_
131	had	_	_	_	_	_	_	_	_
132	underlying	_	_	_	_	_	_	_	_
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38	.	_	_	_	_	_	_	_	_
39	We	_	_	_	_	_	_	_	BeginSeg=Yes
40	propose	_	_	_	_	_	_	_	_
41	Smart	_	_	_	_	_	_	_	_
42	Pooling	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	a	_	_	_	_	_	_	_	_
45	machine	_	_	_	_	_	_	_	_
46	learning	_	_	_	_	_	_	_	_
47	method	_	_	_	_	_	_	_	_
48	that	_	_	_	_	_	_	_	BeginSeg=Yes
49	uses	_	_	_	_	_	_	_	_
50	sociodemographic	_	_	_	_	_	_	_	_
51	data	_	_	_	_	_	_	_	_
52	from	_	_	_	_	_	_	_	_
53	patients	_	_	_	_	_	_	_	_
54	to	_	_	_	_	_	_	_	BeginSeg=Yes
55	increase	_	_	_	_	_	_	_	_
56	the	_	_	_	_	_	_	_	_
57	efficiency	_	_	_	_	_	_	_	_
58	of	_	_	_	_	_	_	_	_
59	pooled	_	_	_	_	_	_	_	_
60	molecular	_	_	_	_	_	_	_	_
61	testing	_	_	_	_	_	_	_	_
62	for	_	_	_	_	_	_	_	_
63	COVID-19	_	_	_	_	_	_	_	_
64	by	_	_	_	_	_	_	_	BeginSeg=Yes
65	arranging	_	_	_	_	_	_	_	_
66	samples	_	_	_	_	_	_	_	_
67	into	_	_	_	_	_	_	_	_
68	all	_	_	_	_	_	_	_	_
69	-	_	_	_	_	_	_	_	_
70	negative	_	_	_	_	_	_	_	_
71	pools	_	_	_	_	_	_	_	_
72	.	_	_	_	_	_	_	_	_
73	We	_	_	_	_	_	_	_	BeginSeg=Yes
74	show	_	_	_	_	_	_	_	_
75	efficiency	_	_	_	_	_	_	_	_
76	gains	_	_	_	_	_	_	_	_
77	of	_	_	_	_	_	_	_	_
78	42	_	_	_	_	_	_	_	_
79	%	_	_	_	_	_	_	_	_
80	with	_	_	_	_	_	_	_	_
81	respect	_	_	_	_	_	_	_	_
82	to	_	_	_	_	_	_	_	_
83	individual	_	_	_	_	_	_	_	_
84	testing	_	_	_	_	_	_	_	_
85	at	_	_	_	_	_	_	_	_
86	disease	_	_	_	_	_	_	_	_
87	prevalence	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
89	up	_	_	_	_	_	_	_	_
90	to	_	_	_	_	_	_	_	_
91	25	_	_	_	_	_	_	_	_
92	%	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	a	_	_	_	_	_	_	_	_
95	regime	_	_	_	_	_	_	_	_
96	in	_	_	_	_	_	_	_	BeginSeg=Yes
97	which	_	_	_	_	_	_	_	_
98	two	_	_	_	_	_	_	_	_
99	-	_	_	_	_	_	_	_	_
100	step	_	_	_	_	_	_	_	_
101	pooling	_	_	_	_	_	_	_	_
102	offers	_	_	_	_	_	_	_	_
103	marginal	_	_	_	_	_	_	_	_
104	efficiency	_	_	_	_	_	_	_	_
105	gains	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	Additionally	_	_	_	_	_	_	_	BeginSeg=Yes
108	,	_	_	_	_	_	_	_	_
109	we	_	_	_	_	_	_	_	_
110	calculate	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	possible	_	_	_	_	_	_	_	_
113	efficiency	_	_	_	_	_	_	_	_
114	gains	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	one	_	_	_	_	_	_	_	_
117	-	_	_	_	_	_	_	_	_
118	and	_	_	_	_	_	_	_	_
119	two	_	_	_	_	_	_	_	_
120	-	_	_	_	_	_	_	_	_
121	dimensional	_	_	_	_	_	_	_	_
122	two	_	_	_	_	_	_	_	_
123	-	_	_	_	_	_	_	_	_
124	step	_	_	_	_	_	_	_	_
125	pooling	_	_	_	_	_	_	_	_
126	strategies	_	_	_	_	_	_	_	_
127	and	_	_	_	_	_	_	_	BeginSeg=Yes
128	present	_	_	_	_	_	_	_	_
129	the	_	_	_	_	_	_	_	_
130	optimal	_	_	_	_	_	_	_	_
131	strategies	_	_	_	_	_	_	_	_
132	for	_	_	_	_	_	_	_	_
133	disease	_	_	_	_	_	_	_	_
134	prevalences	_	_	_	_	_	_	_	_
135	up	_	_	_	_	_	_	_	_
136	to	_	_	_	_	_	_	_	_
137	25	_	_	_	_	_	_	_	_
138	%	_	_	_	_	_	_	_	_
139	.	_	_	_	_	_	_	_	_
140	We	_	_	_	_	_	_	_	BeginSeg=Yes
141	discuss	_	_	_	_	_	_	_	_
142	practical	_	_	_	_	_	_	_	_
143	limitations	_	_	_	_	_	_	_	_
144	to	_	_	_	_	_	_	_	BeginSeg=Yes
145	conduct	_	_	_	_	_	_	_	_
146	pooling	_	_	_	_	_	_	_	_
147	in	_	_	_	_	_	_	_	_
148	the	_	_	_	_	_	_	_	_
149	laboratory	_	_	_	_	_	_	_	_
150	.	_	_	_	_	_	_	_	_

# newdoc_id = 3053729be9dadd6180b0b30ed2048dec12bd0401
1	Gastroenteritis	_	_	_	_	_	_	_	BeginSeg=Yes
2	is	_	_	_	_	_	_	_	_
3	a	_	_	_	_	_	_	_	_
4	common	_	_	_	_	_	_	_	_
5	illness	_	_	_	_	_	_	_	_
6	causing	_	_	_	_	_	_	_	BeginSeg=Yes
7	considerable	_	_	_	_	_	_	_	_
8	morbidity	_	_	_	_	_	_	_	_
9	and	_	_	_	_	_	_	_	_
10	mortality	_	_	_	_	_	_	_	_
11	worldwide	_	_	_	_	_	_	_	_
12	.	_	_	_	_	_	_	_	_
13	Despite	_	_	_	_	_	_	_	BeginSeg=Yes
14	improvements	_	_	_	_	_	_	_	_
15	in	_	_	_	_	_	_	_	_
16	detection	_	_	_	_	_	_	_	_
17	methods	_	_	_	_	_	_	_	_
18	,	_	_	_	_	_	_	_	_
19	a	_	_	_	_	_	_	_	BeginSeg=Yes
20	significant	_	_	_	_	_	_	_	_
21	diagnostic	_	_	_	_	_	_	_	_
22	gap	_	_	_	_	_	_	_	_
23	still	_	_	_	_	_	_	_	_
24	remains	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	Human	_	_	_	_	_	_	_	BeginSeg=Yes
27	bocavirus	_	_	_	_	_	_	_	_
28	(	_	_	_	_	_	_	_	_
29	HBoV)s	_	_	_	_	_	_	_	_
30	,	_	_	_	_	_	_	_	_
31	which	_	_	_	_	_	_	_	BeginSeg=Yes
32	are	_	_	_	_	_	_	_	_
33	associated	_	_	_	_	_	_	_	_
34	with	_	_	_	_	_	_	_	_
35	respiratory	_	_	_	_	_	_	_	_
36	infections	_	_	_	_	_	_	_	_
37	,	_	_	_	_	_	_	_	_
38	have	_	_	_	_	_	_	_	BeginSeg=Yes
39	also	_	_	_	_	_	_	_	_
40	frequently	_	_	_	_	_	_	_	_
41	been	_	_	_	_	_	_	_	_
42	detected	_	_	_	_	_	_	_	_
43	in	_	_	_	_	_	_	_	_
44	stool	_	_	_	_	_	_	_	_
45	samples	_	_	_	_	_	_	_	_
46	in	_	_	_	_	_	_	_	_
47	cases	_	_	_	_	_	_	_	_
48	of	_	_	_	_	_	_	_	_
49	gastroenteritis	_	_	_	_	_	_	_	_
50	,	_	_	_	_	_	_	_	_
51	and	_	_	_	_	_	_	_	BeginSeg=Yes
52	a	_	_	_	_	_	_	_	_
53	tentative	_	_	_	_	_	_	_	_
54	association	_	_	_	_	_	_	_	_
55	between	_	_	_	_	_	_	_	_
56	HBoVs	_	_	_	_	_	_	_	_
57	,	_	_	_	_	_	_	_	_
58	and	_	_	_	_	_	_	_	_
59	in	_	_	_	_	_	_	_	_
60	particular	_	_	_	_	_	_	_	_
61	type-2	_	_	_	_	_	_	_	_
62	HBoVs	_	_	_	_	_	_	_	_
63	,	_	_	_	_	_	_	_	_
64	and	_	_	_	_	_	_	_	_
65	gastroenteritis	_	_	_	_	_	_	_	_
66	has	_	_	_	_	_	_	_	_
67	previously	_	_	_	_	_	_	_	_
68	been	_	_	_	_	_	_	_	_
69	made	_	_	_	_	_	_	_	_
70	.	_	_	_	_	_	_	_	_
71	The	_	_	_	_	_	_	_	BeginSeg=Yes
72	aim	_	_	_	_	_	_	_	_
73	of	_	_	_	_	_	_	_	_
74	this	_	_	_	_	_	_	_	_
75	study	_	_	_	_	_	_	_	_
76	was	_	_	_	_	_	_	_	_
77	to	_	_	_	_	_	_	_	_
78	determine	_	_	_	_	_	_	_	_
79	the	_	_	_	_	_	_	_	_
80	role	_	_	_	_	_	_	_	_
81	of	_	_	_	_	_	_	_	_
82	HBoVs	_	_	_	_	_	_	_	_
83	in	_	_	_	_	_	_	_	_
84	gastroenteritis	_	_	_	_	_	_	_	_
85	,	_	_	_	_	_	_	_	_
86	using	_	_	_	_	_	_	_	BeginSeg=Yes
87	archived	_	_	_	_	_	_	_	_
88	DNA	_	_	_	_	_	_	_	_
89	samples	_	_	_	_	_	_	_	_
90	from	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
92	case	_	_	_	_	_	_	_	_
93	-	_	_	_	_	_	_	_	_
94	control	_	_	_	_	_	_	_	_
95	Infectious	_	_	_	_	_	_	_	_
96	Intestinal	_	_	_	_	_	_	_	_
97	Disease	_	_	_	_	_	_	_	_
98	Study	_	_	_	_	_	_	_	_
99	(	_	_	_	_	_	_	_	_
100	IID	_	_	_	_	_	_	_	_
101	)	_	_	_	_	_	_	_	_
102	.	_	_	_	_	_	_	_	_
103	DNA	_	_	_	_	_	_	_	BeginSeg=Yes
104	extracted	_	_	_	_	_	_	_	BeginSeg=Yes
105	from	_	_	_	_	_	_	_	_
106	stool	_	_	_	_	_	_	_	_
107	samples	_	_	_	_	_	_	_	_
108	from	_	_	_	_	_	_	_	_
109	2,256	_	_	_	_	_	_	_	_
110	cases	_	_	_	_	_	_	_	_
111	and	_	_	_	_	_	_	_	_
112	2,124	_	_	_	_	_	_	_	_
113	controls	_	_	_	_	_	_	_	_
114	were	_	_	_	_	_	_	_	BeginSeg=Yes
115	tested	_	_	_	_	_	_	_	_
116	for	_	_	_	_	_	_	_	_
117	the	_	_	_	_	_	_	_	_
118	presence	_	_	_	_	_	_	_	_
119	of	_	_	_	_	_	_	_	_
120	HBoV	_	_	_	_	_	_	_	_
121	DNA	_	_	_	_	_	_	_	_
122	.	_	_	_	_	_	_	_	_
123	All	_	_	_	_	_	_	_	BeginSeg=Yes
124	samples	_	_	_	_	_	_	_	_
125	were	_	_	_	_	_	_	_	_
126	screened	_	_	_	_	_	_	_	_
127	in	_	_	_	_	_	_	_	_
128	a	_	_	_	_	_	_	_	_
129	real	_	_	_	_	_	_	_	_
130	time	_	_	_	_	_	_	_	_
131	PCR	_	_	_	_	_	_	_	_
132	pan	_	_	_	_	_	_	_	_
133	-	_	_	_	_	_	_	_	_
134	HBoV	_	_	_	_	_	_	_	_
135	assay	_	_	_	_	_	_	_	_
136	,	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	BeginSeg=Yes
138	positive	_	_	_	_	_	_	_	_
139	samples	_	_	_	_	_	_	_	_
140	were	_	_	_	_	_	_	_	_
141	then	_	_	_	_	_	_	_	_
142	tested	_	_	_	_	_	_	_	_
143	in	_	_	_	_	_	_	_	_
144	genotype	_	_	_	_	_	_	_	_
145	1	_	_	_	_	_	_	_	_
146	to	_	_	_	_	_	_	_	_
147	3-specific	_	_	_	_	_	_	_	_
148	assays	_	_	_	_	_	_	_	_
149	.	_	_	_	_	_	_	_	_
150	HBoV	_	_	_	_	_	_	_	BeginSeg=Yes
151	was	_	_	_	_	_	_	_	_
152	detected	_	_	_	_	_	_	_	_
153	in	_	_	_	_	_	_	_	_
154	7.4	_	_	_	_	_	_	_	_
155	%	_	_	_	_	_	_	_	_
156	but	_	_	_	_	_	_	_	BeginSeg=Yes
157	no	_	_	_	_	_	_	_	_
158	significantly	_	_	_	_	_	_	_	_
159	different	_	_	_	_	_	_	_	_
160	prevalence	_	_	_	_	_	_	_	_
161	was	_	_	_	_	_	_	_	_
162	observed	_	_	_	_	_	_	_	_
163	between	_	_	_	_	_	_	_	_
164	cases	_	_	_	_	_	_	_	_
165	and	_	_	_	_	_	_	_	_
166	controls	_	_	_	_	_	_	_	_
167	.	_	_	_	_	_	_	_	_
168	In	_	_	_	_	_	_	_	BeginSeg=Yes
169	the	_	_	_	_	_	_	_	_
170	genotype	_	_	_	_	_	_	_	_
171	-	_	_	_	_	_	_	_	_
172	specific	_	_	_	_	_	_	_	_
173	assays	_	_	_	_	_	_	_	_
174	106	_	_	_	_	_	_	_	_
175	of	_	_	_	_	_	_	_	_
176	the	_	_	_	_	_	_	_	_
177	324	_	_	_	_	_	_	_	_
178	HBoV	_	_	_	_	_	_	_	_
179	-	_	_	_	_	_	_	_	_
180	positive	_	_	_	_	_	_	_	_
181	samples	_	_	_	_	_	_	_	_
182	were	_	_	_	_	_	_	_	_
183	genotyped	_	_	_	_	_	_	_	_
184	,	_	_	_	_	_	_	_	_
185	with	_	_	_	_	_	_	_	BeginSeg=Yes
186	HBoV-1	_	_	_	_	_	_	_	_
187	predominantly	_	_	_	_	_	_	_	_
188	found	_	_	_	_	_	_	_	_
189	in	_	_	_	_	_	_	_	_
190	controls	_	_	_	_	_	_	_	_
191	whilst	_	_	_	_	_	_	_	BeginSeg=Yes
192	HBoV-2	_	_	_	_	_	_	_	_
193	was	_	_	_	_	_	_	_	_
194	more	_	_	_	_	_	_	_	_
195	frequently	_	_	_	_	_	_	_	_
196	associated	_	_	_	_	_	_	_	_
197	with	_	_	_	_	_	_	_	_
198	cases	_	_	_	_	_	_	_	_
199	of	_	_	_	_	_	_	_	_
200	gastroenteritis	_	_	_	_	_	_	_	_
201	(	_	_	_	_	_	_	_	BeginSeg=Yes
202	p,0.01	_	_	_	_	_	_	_	_
203	)	_	_	_	_	_	_	_	_
204	.	_	_	_	_	_	_	_	_

# newdoc_id = 3083c8b34f2b52c612601c0cedbd397681f79d46
1	Wildlife	_	_	_	_	_	_	_	BeginSeg=Yes
2	are	_	_	_	_	_	_	_	_
3	frequently	_	_	_	_	_	_	_	_
4	a	_	_	_	_	_	_	_	_
5	neglected	_	_	_	_	_	_	_	_
6	component	_	_	_	_	_	_	_	_
7	of	_	_	_	_	_	_	_	_
8	One	_	_	_	_	_	_	_	_
9	Health	_	_	_	_	_	_	_	_
10	;	_	_	_	_	_	_	_	_
11	however	_	_	_	_	_	_	_	BeginSeg=Yes
12	,	_	_	_	_	_	_	_	_
13	the	_	_	_	_	_	_	_	_
14	linkages	_	_	_	_	_	_	_	_
15	between	_	_	_	_	_	_	_	_
16	the	_	_	_	_	_	_	_	_
17	health	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	wildlife	_	_	_	_	_	_	_	_
20	and	_	_	_	_	_	_	_	_
21	human	_	_	_	_	_	_	_	_
22	,	_	_	_	_	_	_	_	_
23	domestic	_	_	_	_	_	_	_	_
24	animal	_	_	_	_	_	_	_	_
25	,	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	environmental	_	_	_	_	_	_	_	_
28	health	_	_	_	_	_	_	_	_
29	are	_	_	_	_	_	_	_	_
30	clear	_	_	_	_	_	_	_	_
31	.	_	_	_	_	_	_	_	_
32	The	_	_	_	_	_	_	_	BeginSeg=Yes
33	majority	_	_	_	_	_	_	_	_
34	of	_	_	_	_	_	_	_	_
35	emerging	_	_	_	_	_	_	_	_
36	zoonotic	_	_	_	_	_	_	_	_
37	diseases	_	_	_	_	_	_	_	_
38	are	_	_	_	_	_	_	_	_
39	linked	_	_	_	_	_	_	_	_
40	to	_	_	_	_	_	_	_	_
41	wildlife	_	_	_	_	_	_	_	_
42	,	_	_	_	_	_	_	_	_
43	primarily	_	_	_	_	_	_	_	BeginSeg=Yes
44	driven	_	_	_	_	_	_	_	_
45	by	_	_	_	_	_	_	_	_
46	anthropogenic	_	_	_	_	_	_	_	_
47	land	_	_	_	_	_	_	_	_
48	changes	_	_	_	_	_	_	_	_
49	.	_	_	_	_	_	_	_	_
50	Despite	_	_	_	_	_	_	_	BeginSeg=Yes
51	this	_	_	_	_	_	_	_	_
52	risk	_	_	_	_	_	_	_	_
53	,	_	_	_	_	_	_	_	_
54	wildlife	_	_	_	_	_	_	_	BeginSeg=Yes
55	have	_	_	_	_	_	_	_	_
56	important	_	_	_	_	_	_	_	_
57	links	_	_	_	_	_	_	_	_
58	to	_	_	_	_	_	_	_	_
59	people	_	_	_	_	_	_	_	_
60	as	_	_	_	_	_	_	_	_
61	environmental	_	_	_	_	_	_	_	_
62	indicators	_	_	_	_	_	_	_	_
63	,	_	_	_	_	_	_	_	_
64	food	_	_	_	_	_	_	_	_
65	security	_	_	_	_	_	_	_	_
66	and	_	_	_	_	_	_	_	_
67	safety	_	_	_	_	_	_	_	_
68	,	_	_	_	_	_	_	_	_
69	and	_	_	_	_	_	_	_	_
70	through	_	_	_	_	_	_	_	_
71	human	_	_	_	_	_	_	_	_
72	livelihoods	_	_	_	_	_	_	_	_
73	.	_	_	_	_	_	_	_	_
74	This	_	_	_	_	_	_	_	BeginSeg=Yes
75	chapter	_	_	_	_	_	_	_	_
76	will	_	_	_	_	_	_	_	_
77	describe	_	_	_	_	_	_	_	_
78	these	_	_	_	_	_	_	_	_
79	linkages	_	_	_	_	_	_	_	_
80	and	_	_	_	_	_	_	_	BeginSeg=Yes
81	demonstrate	_	_	_	_	_	_	_	_
82	the	_	_	_	_	_	_	_	_
83	need	_	_	_	_	_	_	_	_
84	to	_	_	_	_	_	_	_	BeginSeg=Yes
85	understand	_	_	_	_	_	_	_	_
86	these	_	_	_	_	_	_	_	_
87	linkages	_	_	_	_	_	_	_	_
88	through	_	_	_	_	_	_	_	_
89	targeted	_	_	_	_	_	_	_	_
90	surveillance	_	_	_	_	_	_	_	_
91	and	_	_	_	_	_	_	_	_
92	understanding	_	_	_	_	_	_	_	_
93	the	_	_	_	_	_	_	_	_
94	ecology	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	wildlife	_	_	_	_	_	_	_	_
97	diseases	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	While	_	_	_	_	_	_	_	BeginSeg=Yes
100	the	_	_	_	_	_	_	_	_
101	management	_	_	_	_	_	_	_	_
102	of	_	_	_	_	_	_	_	_
103	wildlife	_	_	_	_	_	_	_	_
104	diseases	_	_	_	_	_	_	_	_
105	presents	_	_	_	_	_	_	_	_
106	a	_	_	_	_	_	_	_	_
107	significant	_	_	_	_	_	_	_	_
108	challenge	_	_	_	_	_	_	_	_
109	,	_	_	_	_	_	_	_	_
110	such	_	_	_	_	_	_	_	BeginSeg=Yes
111	practices	_	_	_	_	_	_	_	_
112	will	_	_	_	_	_	_	_	_
113	greatly	_	_	_	_	_	_	_	_
114	improve	_	_	_	_	_	_	_	_
115	the	_	_	_	_	_	_	_	_
116	health	_	_	_	_	_	_	_	_
117	of	_	_	_	_	_	_	_	_
118	people	_	_	_	_	_	_	_	_
119	,	_	_	_	_	_	_	_	_
120	domestic	_	_	_	_	_	_	_	_
121	animals	_	_	_	_	_	_	_	_
122	,	_	_	_	_	_	_	_	_
123	wildlife	_	_	_	_	_	_	_	_
124	and	_	_	_	_	_	_	_	_
125	the	_	_	_	_	_	_	_	_
126	environment	_	_	_	_	_	_	_	_
127	.	_	_	_	_	_	_	_	_

# newdoc_id = 308feddda1dfd44c1ebb38dcc2d06bb6b2d5dddf
1	This	_	_	_	_	_	_	_	BeginSeg=Yes
2	research	_	_	_	_	_	_	_	_
3	examines	_	_	_	_	_	_	_	_
4	whether	_	_	_	_	_	_	_	_
5	cities	_	_	_	_	_	_	_	_
6	are	_	_	_	_	_	_	_	_
7	getting	_	_	_	_	_	_	_	_
8	more	_	_	_	_	_	_	_	_
9	equally	_	_	_	_	_	_	_	_
10	accessible	_	_	_	_	_	_	_	_
11	and	_	_	_	_	_	_	_	_
12	connected	_	_	_	_	_	_	_	_
13	via	_	_	_	_	_	_	_	_
14	high	_	_	_	_	_	_	_	_
15	-	_	_	_	_	_	_	_	_
16	speed	_	_	_	_	_	_	_	_
17	rail	_	_	_	_	_	_	_	_
18	(	_	_	_	_	_	_	_	_
19	HSR	_	_	_	_	_	_	_	_
20	)	_	_	_	_	_	_	_	_
21	in	_	_	_	_	_	_	_	_
22	China	_	_	_	_	_	_	_	_
23	over	_	_	_	_	_	_	_	_
24	the	_	_	_	_	_	_	_	_
25	period	_	_	_	_	_	_	_	_
26	from	_	_	_	_	_	_	_	_
27	2010	_	_	_	_	_	_	_	_
28	to	_	_	_	_	_	_	_	_
29	2015	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	Existing	_	_	_	_	_	_	_	BeginSeg=Yes
32	studies	_	_	_	_	_	_	_	_
33	mainly	_	_	_	_	_	_	_	_
34	use	_	_	_	_	_	_	_	_
35	network	_	_	_	_	_	_	_	_
36	centralities	_	_	_	_	_	_	_	_
37	to	_	_	_	_	_	_	_	BeginSeg=Yes
38	describe	_	_	_	_	_	_	_	_
39	the	_	_	_	_	_	_	_	_
40	spatial	_	_	_	_	_	_	_	_
41	pattern	_	_	_	_	_	_	_	_
42	of	_	_	_	_	_	_	_	_
43	HSR	_	_	_	_	_	_	_	_
44	network	_	_	_	_	_	_	_	_
45	without	_	_	_	_	_	_	_	BeginSeg=Yes
46	measuring	_	_	_	_	_	_	_	_
47	the	_	_	_	_	_	_	_	_
48	spatial	_	_	_	_	_	_	_	_
49	disparity	_	_	_	_	_	_	_	_
50	of	_	_	_	_	_	_	_	_
51	these	_	_	_	_	_	_	_	_
52	centralities	_	_	_	_	_	_	_	_
53	,	_	_	_	_	_	_	_	_
54	and	_	_	_	_	_	_	_	BeginSeg=Yes
55	most	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	them	_	_	_	_	_	_	_	_
58	rely	_	_	_	_	_	_	_	_
59	on	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	infrastructure	_	_	_	_	_	_	_	_
62	network	_	_	_	_	_	_	_	_
63	and	_	_	_	_	_	_	_	BeginSeg=Yes
64	thus	_	_	_	_	_	_	_	_
65	fail	_	_	_	_	_	_	_	_
66	to	_	_	_	_	_	_	_	_
67	incorporate	_	_	_	_	_	_	_	_
68	HSR	_	_	_	_	_	_	_	_
69	service	_	_	_	_	_	_	_	_
70	quality	_	_	_	_	_	_	_	_
71	in	_	_	_	_	_	_	_	_
72	the	_	_	_	_	_	_	_	_
73	centrality	_	_	_	_	_	_	_	_
74	measures	_	_	_	_	_	_	_	_
75	.	_	_	_	_	_	_	_	_
76	Using	_	_	_	_	_	_	_	BeginSeg=Yes
77	HSR	_	_	_	_	_	_	_	_
78	timetable	_	_	_	_	_	_	_	_
79	data	_	_	_	_	_	_	_	_
80	,	_	_	_	_	_	_	_	_
81	we	_	_	_	_	_	_	_	BeginSeg=Yes
82	incorporate	_	_	_	_	_	_	_	_
83	both	_	_	_	_	_	_	_	_
84	scheduled	_	_	_	_	_	_	_	_
85	travel	_	_	_	_	_	_	_	_
86	time	_	_	_	_	_	_	_	_
87	and	_	_	_	_	_	_	_	_
88	daily	_	_	_	_	_	_	_	_
89	frequency	_	_	_	_	_	_	_	_
90	of	_	_	_	_	_	_	_	_
91	each	_	_	_	_	_	_	_	_
92	origin	_	_	_	_	_	_	_	_
93	-	_	_	_	_	_	_	_	_
94	destination	_	_	_	_	_	_	_	_
95	city	_	_	_	_	_	_	_	_
96	pair	_	_	_	_	_	_	_	_
97	into	_	_	_	_	_	_	_	_
98	three	_	_	_	_	_	_	_	_
99	centrality	_	_	_	_	_	_	_	_
100	measures	_	_	_	_	_	_	_	_
101	and	_	_	_	_	_	_	_	BeginSeg=Yes
102	further	_	_	_	_	_	_	_	_
103	quantify	_	_	_	_	_	_	_	_
104	their	_	_	_	_	_	_	_	_
105	inequalities	_	_	_	_	_	_	_	_
106	using	_	_	_	_	_	_	_	BeginSeg=Yes
107-108	Theil's	_	_	_	_	_	_	_	_
107	Theil	_	_	_	_	_	_	_	_
108	's	_	_	_	_	_	_	_	_
109	T	_	_	_	_	_	_	_	_
110	index	_	_	_	_	_	_	_	_
111	.	_	_	_	_	_	_	_	_
112	We	_	_	_	_	_	_	_	BeginSeg=Yes
113	find	_	_	_	_	_	_	_	_
114	that	_	_	_	_	_	_	_	BeginSeg=Yes
115	as	_	_	_	_	_	_	_	BeginSeg=Yes
116	the	_	_	_	_	_	_	_	_
117	HSR	_	_	_	_	_	_	_	_
118	network	_	_	_	_	_	_	_	_
119	expands	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	cities	_	_	_	_	_	_	_	BeginSeg=Yes
122	appear	_	_	_	_	_	_	_	_
123	to	_	_	_	_	_	_	_	_
124	be	_	_	_	_	_	_	_	_
125	more	_	_	_	_	_	_	_	_
126	equal	_	_	_	_	_	_	_	_
127	in	_	_	_	_	_	_	_	_
128	terms	_	_	_	_	_	_	_	_
129	of	_	_	_	_	_	_	_	_
130	accessibility	_	_	_	_	_	_	_	_
131	,	_	_	_	_	_	_	_	_
132	but	_	_	_	_	_	_	_	BeginSeg=Yes
133	their	_	_	_	_	_	_	_	_
134	disparities	_	_	_	_	_	_	_	_
135	in	_	_	_	_	_	_	_	_
136	connectivity	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	_
138	transitivity	_	_	_	_	_	_	_	_
139	depend	_	_	_	_	_	_	_	_
140	on	_	_	_	_	_	_	_	_
141	the	_	_	_	_	_	_	_	_
142	dimensions	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	comparison	_	_	_	_	_	_	_	_
145	.	_	_	_	_	_	_	_	_
146	In	_	_	_	_	_	_	_	BeginSeg=Yes
147	general	_	_	_	_	_	_	_	_
148	,	_	_	_	_	_	_	_	_
149	although	_	_	_	_	_	_	_	BeginSeg=Yes
150	the	_	_	_	_	_	_	_	_
151	difference	_	_	_	_	_	_	_	_
152	between	_	_	_	_	_	_	_	_
153	economic	_	_	_	_	_	_	_	_
154	regions	_	_	_	_	_	_	_	_
155	or	_	_	_	_	_	_	_	_
156	between	_	_	_	_	_	_	_	_
157	megalopolises	_	_	_	_	_	_	_	_
158	has	_	_	_	_	_	_	_	_
159	reduced	_	_	_	_	_	_	_	_
160	,	_	_	_	_	_	_	_	_
161	small	_	_	_	_	_	_	_	BeginSeg=Yes
162	/	_	_	_	_	_	_	_	_
163	medium	_	_	_	_	_	_	_	_
164	-	_	_	_	_	_	_	_	_
165	sized	_	_	_	_	_	_	_	_
166	cities	_	_	_	_	_	_	_	_
167	not	_	_	_	_	_	_	_	BeginSeg=Yes
168	belonging	_	_	_	_	_	_	_	_
169	to	_	_	_	_	_	_	_	_
170	any	_	_	_	_	_	_	_	_
171	major	_	_	_	_	_	_	_	_
172	city	_	_	_	_	_	_	_	_
173	cluster	_	_	_	_	_	_	_	_
174	are	_	_	_	_	_	_	_	BeginSeg=Yes
175	further	_	_	_	_	_	_	_	_
176	lagged	_	_	_	_	_	_	_	_
177	behind	_	_	_	_	_	_	_	_
178	in	_	_	_	_	_	_	_	_
179	HSR	_	_	_	_	_	_	_	_
180	development	_	_	_	_	_	_	_	_
181	.	_	_	_	_	_	_	_	_
182	The	_	_	_	_	_	_	_	BeginSeg=Yes
183	difference	_	_	_	_	_	_	_	_
184	between	_	_	_	_	_	_	_	_
185	core	_	_	_	_	_	_	_	_
186	and	_	_	_	_	_	_	_	_
187	non	_	_	_	_	_	_	_	_
188	-	_	_	_	_	_	_	_	_
189	core	_	_	_	_	_	_	_	_
190	cities	_	_	_	_	_	_	_	_
191	in	_	_	_	_	_	_	_	_
192	the	_	_	_	_	_	_	_	_
193	same	_	_	_	_	_	_	_	_
194	megalopolises	_	_	_	_	_	_	_	_
195	has	_	_	_	_	_	_	_	_
196	decreased	_	_	_	_	_	_	_	_
197	despite	_	_	_	_	_	_	_	BeginSeg=Yes
198	that	_	_	_	_	_	_	_	_
199	non	_	_	_	_	_	_	_	_
200	-	_	_	_	_	_	_	_	_
201	core	_	_	_	_	_	_	_	_
202	cities	_	_	_	_	_	_	_	_
203	are	_	_	_	_	_	_	_	_
204	increasingly	_	_	_	_	_	_	_	_
205	relying	_	_	_	_	_	_	_	_
206	on	_	_	_	_	_	_	_	_
207	core	_	_	_	_	_	_	_	_
208	cities	_	_	_	_	_	_	_	_
209	to	_	_	_	_	_	_	_	BeginSeg=Yes
210	access	_	_	_	_	_	_	_	_
211	other	_	_	_	_	_	_	_	_
212	regions	_	_	_	_	_	_	_	_
213	.	_	_	_	_	_	_	_	_

# newdoc_id = 30d2d2d37c2a884db55ab21d1cbd92abcff95fa2
1	Angiotensin	_	_	_	_	_	_	_	BeginSeg=Yes
2	II	_	_	_	_	_	_	_	_
3	(	_	_	_	_	_	_	_	_
4	Ang	_	_	_	_	_	_	_	_
5	II	_	_	_	_	_	_	_	_
6	)	_	_	_	_	_	_	_	_
7	plays	_	_	_	_	_	_	_	_
8	an	_	_	_	_	_	_	_	_
9	important	_	_	_	_	_	_	_	_
10	role	_	_	_	_	_	_	_	_
11	in	_	_	_	_	_	_	_	_
12	cardiomyocyte	_	_	_	_	_	_	_	_
13	hypertrophy	_	_	_	_	_	_	_	_
14	.	_	_	_	_	_	_	_	_
15	The	_	_	_	_	_	_	_	BeginSeg=Yes
16	combined	_	_	_	_	_	_	_	_
17	effect	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	hepatocyte	_	_	_	_	_	_	_	_
20	growth	_	_	_	_	_	_	_	_
21	factor	_	_	_	_	_	_	_	_
22	(	_	_	_	_	_	_	_	_
23	HGF	_	_	_	_	_	_	_	_
24	)	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	Ang	_	_	_	_	_	_	_	_
27	II	_	_	_	_	_	_	_	_
28	on	_	_	_	_	_	_	_	_
29	cardiomyocytes	_	_	_	_	_	_	_	_
30	is	_	_	_	_	_	_	_	_
31	unknown	_	_	_	_	_	_	_	_
32	.	_	_	_	_	_	_	_	_
33	The	_	_	_	_	_	_	_	BeginSeg=Yes
34	present	_	_	_	_	_	_	_	_
35	study	_	_	_	_	_	_	_	_
36	was	_	_	_	_	_	_	_	_
37	designed	_	_	_	_	_	_	_	_
38	to	_	_	_	_	_	_	_	BeginSeg=Yes
39	determine	_	_	_	_	_	_	_	_
40	the	_	_	_	_	_	_	_	_
41	effect	_	_	_	_	_	_	_	_
42	of	_	_	_	_	_	_	_	_
43	HGF	_	_	_	_	_	_	_	_
44	on	_	_	_	_	_	_	_	_
45	cardiomyocyte	_	_	_	_	_	_	_	_
46	hypertrophy	_	_	_	_	_	_	_	_
47	and	_	_	_	_	_	_	_	BeginSeg=Yes
48	to	_	_	_	_	_	_	_	_
49	explore	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	combined	_	_	_	_	_	_	_	_
52	effect	_	_	_	_	_	_	_	_
53	of	_	_	_	_	_	_	_	_
54	HGF	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	_
56	Ang	_	_	_	_	_	_	_	_
57	II	_	_	_	_	_	_	_	_
58	on	_	_	_	_	_	_	_	_
59	cardiomyocyte	_	_	_	_	_	_	_	_
60	hypertrophy	_	_	_	_	_	_	_	_
61	.	_	_	_	_	_	_	_	_
62	Primary	_	_	_	_	_	_	_	BeginSeg=Yes
63	cardiomyocytes	_	_	_	_	_	_	_	_
64	were	_	_	_	_	_	_	_	_
65	isolated	_	_	_	_	_	_	_	_
66	from	_	_	_	_	_	_	_	_
67	neonatal	_	_	_	_	_	_	_	_
68	rat	_	_	_	_	_	_	_	_
69	hearts	_	_	_	_	_	_	_	_
70	and	_	_	_	_	_	_	_	BeginSeg=Yes
71	cultured	_	_	_	_	_	_	_	_
72	in	_	_	_	_	_	_	_	_
73	vitro	_	_	_	_	_	_	_	_
74	.	_	_	_	_	_	_	_	_
75	Cells	_	_	_	_	_	_	_	BeginSeg=Yes
76	were	_	_	_	_	_	_	_	_
77	treated	_	_	_	_	_	_	_	_
78	with	_	_	_	_	_	_	_	_
79	Ang	_	_	_	_	_	_	_	_
80	II	_	_	_	_	_	_	_	_
81	(	_	_	_	_	_	_	_	BeginSeg=Yes
82	1	_	_	_	_	_	_	_	_
83	µM	_	_	_	_	_	_	_	_
84	)	_	_	_	_	_	_	_	_
85	alone	_	_	_	_	_	_	_	BeginSeg=Yes
86	,	_	_	_	_	_	_	_	_
87	HGF	_	_	_	_	_	_	_	_
88	(	_	_	_	_	_	_	_	BeginSeg=Yes
89	10	_	_	_	_	_	_	_	_
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75	CoViD-19	_	_	_	_	_	_	_	_
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89	innate	_	_	_	_	_	_	_	_
90	immune	_	_	_	_	_	_	_	_
91	response	_	_	_	_	_	_	_	_
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102	compounds	_	_	_	_	_	_	_	_
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111	main	_	_	_	_	_	_	_	_
112	interactions	_	_	_	_	_	_	_	_
113	in	_	_	_	_	_	_	_	_
114	inhibitor	_	_	_	_	_	_	_	_
115	-	_	_	_	_	_	_	_	_
116	enzyme	_	_	_	_	_	_	_	_
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120	docking	_	_	_	_	_	_	_	_
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125	Autodock	_	_	_	_	_	_	_	_
126	Vina	_	_	_	_	_	_	_	_
127	.	_	_	_	_	_	_	_	_
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142	protease	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	coronavirus	_	_	_	_	_	_	_	_
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148	lepidine	_	_	_	_	_	_	_	_
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150	,	_	_	_	_	_	_	_	_
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152	folic	_	_	_	_	_	_	_	_
153	acid	_	_	_	_	_	_	_	_
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158	enzyme	_	_	_	_	_	_	_	_
159	,	_	_	_	_	_	_	_	_
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161	hydrogen	_	_	_	_	_	_	_	_
162	bonds	_	_	_	_	_	_	_	_
163	have	_	_	_	_	_	_	_	_
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167	1.69	_	_	_	_	_	_	_	_
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183	strategy	_	_	_	_	_	_	_	_
184	for	_	_	_	_	_	_	_	_
185	CoViD-19	_	_	_	_	_	_	_	_
186	.	_	_	_	_	_	_	_	_

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88	;	_	_	_	_	_	_	_	_
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90	the	_	_	_	_	_	_	_	_
91	Huaxi	_	_	_	_	_	_	_	_
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96	(	_	_	_	_	_	_	_	_
97	HEI	_	_	_	_	_	_	_	_
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107	experienced	_	_	_	_	_	_	_	_
108	high	_	_	_	_	_	_	_	_
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113	/	_	_	_	_	_	_	_	_
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118	the	_	_	_	_	_	_	_	_
119	COVID-19	_	_	_	_	_	_	_	_
120	outbreak	_	_	_	_	_	_	_	_
121	.	_	_	_	_	_	_	_	_
122	Respondents	_	_	_	_	_	_	_	BeginSeg=Yes
123	who	_	_	_	_	_	_	_	BeginSeg=Yes
124	worried	_	_	_	_	_	_	_	_
125	about	_	_	_	_	_	_	_	_
126	their	_	_	_	_	_	_	_	_
127	physical	_	_	_	_	_	_	_	_
128	health	_	_	_	_	_	_	_	_
129	and	_	_	_	_	_	_	_	BeginSeg=Yes
130	those	_	_	_	_	_	_	_	_
131	who	_	_	_	_	_	_	_	BeginSeg=Yes
132	had	_	_	_	_	_	_	_	_
133	COVID-19	_	_	_	_	_	_	_	_
134	infected	_	_	_	_	_	_	_	_
135	friends	_	_	_	_	_	_	_	_
136	or	_	_	_	_	_	_	_	_
137	close	_	_	_	_	_	_	_	_
138	relatives	_	_	_	_	_	_	_	_
139	were	_	_	_	_	_	_	_	BeginSeg=Yes
140	more	_	_	_	_	_	_	_	_
141	likely	_	_	_	_	_	_	_	_
142	to	_	_	_	_	_	_	_	_
143	have	_	_	_	_	_	_	_	_
144	high	_	_	_	_	_	_	_	_
145	HEI	_	_	_	_	_	_	_	_
146	levels	_	_	_	_	_	_	_	_
147	,	_	_	_	_	_	_	_	_
148	than	_	_	_	_	_	_	_	_
149	those	_	_	_	_	_	_	_	_
150	without	_	_	_	_	_	_	_	_
151	these	_	_	_	_	_	_	_	_
152	characteristics	_	_	_	_	_	_	_	_
153	.	_	_	_	_	_	_	_	_
154	Further	_	_	_	_	_	_	_	BeginSeg=Yes
155	,	_	_	_	_	_	_	_	_
156	family	_	_	_	_	_	_	_	_
157	relationship	_	_	_	_	_	_	_	_
158	was	_	_	_	_	_	_	_	_
159	found	_	_	_	_	_	_	_	_
160	to	_	_	_	_	_	_	_	_
161	have	_	_	_	_	_	_	_	_
162	an	_	_	_	_	_	_	_	_
163	independent	_	_	_	_	_	_	_	_
164	protective	_	_	_	_	_	_	_	_
165	effect	_	_	_	_	_	_	_	_
166	against	_	_	_	_	_	_	_	_
167	high	_	_	_	_	_	_	_	_
168	HEI	_	_	_	_	_	_	_	_
169	levels	_	_	_	_	_	_	_	_
170	.	_	_	_	_	_	_	_	_
171	Their	_	_	_	_	_	_	_	BeginSeg=Yes
172	main	_	_	_	_	_	_	_	_
173	concerns	_	_	_	_	_	_	_	_
174	were	_	_	_	_	_	_	_	_
175	that	_	_	_	_	_	_	_	_
176	their	_	_	_	_	_	_	_	_
177	families	_	_	_	_	_	_	_	_
178	would	_	_	_	_	_	_	_	_
179	not	_	_	_	_	_	_	_	_
180	be	_	_	_	_	_	_	_	_
181	cared	_	_	_	_	_	_	_	_
182	for	_	_	_	_	_	_	_	_
183	and	_	_	_	_	_	_	_	_
184	that	_	_	_	_	_	_	_	_
185	they	_	_	_	_	_	_	_	_
186	would	_	_	_	_	_	_	_	_
187	not	_	_	_	_	_	_	_	_
188	be	_	_	_	_	_	_	_	_
189	able	_	_	_	_	_	_	_	_
190	to	_	_	_	_	_	_	_	_
191	work	_	_	_	_	_	_	_	_
192	properly	_	_	_	_	_	_	_	_
193	.	_	_	_	_	_	_	_	_
194	Compared	_	_	_	_	_	_	_	BeginSeg=Yes
195	to	_	_	_	_	_	_	_	_
196	respondents	_	_	_	_	_	_	_	_
197	with	_	_	_	_	_	_	_	_
198	clear	_	_	_	_	_	_	_	_
199	emotional	_	_	_	_	_	_	_	_
200	problems	_	_	_	_	_	_	_	_
201	,	_	_	_	_	_	_	_	_
202	those	_	_	_	_	_	_	_	BeginSeg=Yes
203	with	_	_	_	_	_	_	_	_
204	somewhat	_	_	_	_	_	_	_	_
205	hidden	_	_	_	_	_	_	_	_
206	emotional	_	_	_	_	_	_	_	_
207	issues	_	_	_	_	_	_	_	_
208	adopted	_	_	_	_	_	_	_	_
209	more	_	_	_	_	_	_	_	_
210	positive	_	_	_	_	_	_	_	_
211	coping	_	_	_	_	_	_	_	_
212	measures	_	_	_	_	_	_	_	_
213	.	_	_	_	_	_	_	_	_
214	Conclusions	_	_	_	_	_	_	_	BeginSeg=Yes
215	.	_	_	_	_	_	_	_	_
216	About	_	_	_	_	_	_	_	BeginSeg=Yes
217	a	_	_	_	_	_	_	_	_
218	quarter	_	_	_	_	_	_	_	_
219	of	_	_	_	_	_	_	_	_
220	medical	_	_	_	_	_	_	_	_
221	staff	_	_	_	_	_	_	_	_
222	experienced	_	_	_	_	_	_	_	_
223	psychological	_	_	_	_	_	_	_	_
224	problems	_	_	_	_	_	_	_	_
225	during	_	_	_	_	_	_	_	_
226	the	_	_	_	_	_	_	_	_
227	pandemic	_	_	_	_	_	_	_	_
228	of	_	_	_	_	_	_	_	_
229	COVID-19	_	_	_	_	_	_	_	_
230	.	_	_	_	_	_	_	_	_
231	The	_	_	_	_	_	_	_	BeginSeg=Yes
232	psychological	_	_	_	_	_	_	_	_
233	impact	_	_	_	_	_	_	_	_
234	of	_	_	_	_	_	_	_	_
235	stressful	_	_	_	_	_	_	_	_
236	events	_	_	_	_	_	_	_	_
237	was	_	_	_	_	_	_	_	_
238	related	_	_	_	_	_	_	_	_
239	to	_	_	_	_	_	_	_	_
240	worrying	_	_	_	_	_	_	_	_
241	about	_	_	_	_	_	_	_	_
242	their	_	_	_	_	_	_	_	_
243	physical	_	_	_	_	_	_	_	_
244	health	_	_	_	_	_	_	_	_
245	,	_	_	_	_	_	_	_	_
246	having	_	_	_	_	_	_	_	_
247	close	_	_	_	_	_	_	_	_
248	COVID-19	_	_	_	_	_	_	_	_
249	infected	_	_	_	_	_	_	_	_
250	acquaintances	_	_	_	_	_	_	_	_
251	and	_	_	_	_	_	_	_	_
252	family	_	_	_	_	_	_	_	_
253	relationship	_	_	_	_	_	_	_	_
254	issues	_	_	_	_	_	_	_	_
255	.	_	_	_	_	_	_	_	_
256	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
257	,	_	_	_	_	_	_	_	_
258	the	_	_	_	_	_	_	_	_
259	psychological	_	_	_	_	_	_	_	_
260	supprot	_	_	_	_	_	_	_	_
261	for	_	_	_	_	_	_	_	_
262	medical	_	_	_	_	_	_	_	_
263	staff	_	_	_	_	_	_	_	_
264	fighting	_	_	_	_	_	_	_	_
265	in	_	_	_	_	_	_	_	_
266	the	_	_	_	_	_	_	_	_
267	COVID-19	_	_	_	_	_	_	_	_
268	pandemic	_	_	_	_	_	_	_	_
269	may	_	_	_	_	_	_	_	_
270	be	_	_	_	_	_	_	_	_
271	needed	_	_	_	_	_	_	_	_
272	.	_	_	_	_	_	_	_	_

# newdoc_id = 351d20dcf8e841056a5e9884ab688e120db82620
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2	infectious	_	_	_	_	_	_	_	_
3	bronchitis	_	_	_	_	_	_	_	_
4	(	_	_	_	_	_	_	_	_
5	IB	_	_	_	_	_	_	_	_
6	)	_	_	_	_	_	_	_	_
7	is	_	_	_	_	_	_	_	_
8	a	_	_	_	_	_	_	_	_
9	major	_	_	_	_	_	_	_	_
10	cause	_	_	_	_	_	_	_	_
11	of	_	_	_	_	_	_	_	_
12	economic	_	_	_	_	_	_	_	_
13	losses	_	_	_	_	_	_	_	_
14	in	_	_	_	_	_	_	_	_
15	poultry	_	_	_	_	_	_	_	_
16	industry	_	_	_	_	_	_	_	_
17	.	_	_	_	_	_	_	_	_
18	The	_	_	_	_	_	_	_	BeginSeg=Yes
19	IB	_	_	_	_	_	_	_	_
20	virus	_	_	_	_	_	_	_	_
21	primarily	_	_	_	_	_	_	_	_
22	affects	_	_	_	_	_	_	_	_
23	respiratory	_	_	_	_	_	_	_	_
24	tract	_	_	_	_	_	_	_	_
25	,	_	_	_	_	_	_	_	_
26	but	_	_	_	_	_	_	_	BeginSeg=Yes
27	various	_	_	_	_	_	_	_	_
28	strains	_	_	_	_	_	_	_	_
29	differ	_	_	_	_	_	_	_	_
30	in	_	_	_	_	_	_	_	_
31	their	_	_	_	_	_	_	_	_
32	tropism	_	_	_	_	_	_	_	_
33	for	_	_	_	_	_	_	_	_
34	other	_	_	_	_	_	_	_	_
35	target	_	_	_	_	_	_	_	_
36	organs	_	_	_	_	_	_	_	_
37	such	_	_	_	_	_	_	_	BeginSeg=Yes
38	as	_	_	_	_	_	_	_	_
39	kidney	_	_	_	_	_	_	_	_
40	and	_	_	_	_	_	_	_	_
41	alimentary	_	_	_	_	_	_	_	_
42	tract	_	_	_	_	_	_	_	_
43	.	_	_	_	_	_	_	_	_
44	The	_	_	_	_	_	_	_	BeginSeg=Yes
45	objective	_	_	_	_	_	_	_	_
46	of	_	_	_	_	_	_	_	_
47	this	_	_	_	_	_	_	_	_
48	study	_	_	_	_	_	_	_	_
49	was	_	_	_	_	_	_	_	_
50	to	_	_	_	_	_	_	_	_
51	estimate	_	_	_	_	_	_	_	_
52	the	_	_	_	_	_	_	_	_
53	pathogenicity	_	_	_	_	_	_	_	_
54	of	_	_	_	_	_	_	_	_
55	Iranian	_	_	_	_	_	_	_	_
56	IBV	_	_	_	_	_	_	_	_
57	variant	_	_	_	_	_	_	_	_
58	(	_	_	_	_	_	_	_	_
59	IR-1	_	_	_	_	_	_	_	_
60	)	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	which	_	_	_	_	_	_	_	BeginSeg=Yes
63	is	_	_	_	_	_	_	_	_
64	limited	_	_	_	_	_	_	_	_
65	exclusively	_	_	_	_	_	_	_	_
66	to	_	_	_	_	_	_	_	_
67	Iran	_	_	_	_	_	_	_	_
68	.	_	_	_	_	_	_	_	_
69	Specific	_	_	_	_	_	_	_	BeginSeg=Yes
70	pathogen	_	_	_	_	_	_	_	_
71	free	_	_	_	_	_	_	_	_
72	chicks	_	_	_	_	_	_	_	_
73	were	_	_	_	_	_	_	_	_
74	inoculated	_	_	_	_	_	_	_	_
75	intranasally	_	_	_	_	_	_	_	_
76	.	_	_	_	_	_	_	_	_
77	Sera	_	_	_	_	_	_	_	BeginSeg=Yes
78	,	_	_	_	_	_	_	_	_
79	fecal	_	_	_	_	_	_	_	_
80	swabs	_	_	_	_	_	_	_	_
81	and	_	_	_	_	_	_	_	_
82	different	_	_	_	_	_	_	_	_
83	tissue	_	_	_	_	_	_	_	_
84	samples	_	_	_	_	_	_	_	_
85	were	_	_	_	_	_	_	_	_
86	collected	_	_	_	_	_	_	_	_
87	on	_	_	_	_	_	_	_	_
88	different	_	_	_	_	_	_	_	_
89	days	_	_	_	_	_	_	_	_
90	post	_	_	_	_	_	_	_	_
91	infection	_	_	_	_	_	_	_	_
92	(	_	_	_	_	_	_	_	_
93	DPI	_	_	_	_	_	_	_	_
94	)	_	_	_	_	_	_	_	_
95	.	_	_	_	_	_	_	_	_
96	Clinical	_	_	_	_	_	_	_	BeginSeg=Yes
97	signs	_	_	_	_	_	_	_	_
98	,	_	_	_	_	_	_	_	_
99	gross	_	_	_	_	_	_	_	_
100	pathology	_	_	_	_	_	_	_	_
101	and	_	_	_	_	_	_	_	_
102	histological	_	_	_	_	_	_	_	_
103	changes	_	_	_	_	_	_	_	_
104	were	_	_	_	_	_	_	_	_
105	recorded	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	The	_	_	_	_	_	_	_	BeginSeg=Yes
108	viral	_	_	_	_	_	_	_	_
109	load	_	_	_	_	_	_	_	_
110	was	_	_	_	_	_	_	_	_
111	quantified	_	_	_	_	_	_	_	_
112	in	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	RNA	_	_	_	_	_	_	_	_
115	extractions	_	_	_	_	_	_	_	_
116	from	_	_	_	_	_	_	_	_
117	different	_	_	_	_	_	_	_	_
118	tissue	_	_	_	_	_	_	_	_
119	samples	_	_	_	_	_	_	_	_
120	using	_	_	_	_	_	_	_	BeginSeg=Yes
121	real	_	_	_	_	_	_	_	_
122	-	_	_	_	_	_	_	_	_
123	time	_	_	_	_	_	_	_	_
124	PCR	_	_	_	_	_	_	_	_
125	.	_	_	_	_	_	_	_	_
126	Anti	_	_	_	_	_	_	_	BeginSeg=Yes
127	-	_	_	_	_	_	_	_	_
128	IBV	_	_	_	_	_	_	_	_
129	antibodies	_	_	_	_	_	_	_	_
130	were	_	_	_	_	_	_	_	_
131	detected	_	_	_	_	_	_	_	_
132	in	_	_	_	_	_	_	_	_
133	serum	_	_	_	_	_	_	_	_
134	samples	_	_	_	_	_	_	_	_
135	.	_	_	_	_	_	_	_	_
136	The	_	_	_	_	_	_	_	BeginSeg=Yes
137	IgG	_	_	_	_	_	_	_	_
138	antibody	_	_	_	_	_	_	_	_
139	were	_	_	_	_	_	_	_	_
140	found	_	_	_	_	_	_	_	_
141	on	_	_	_	_	_	_	_	_
142	21	_	_	_	_	_	_	_	_
143	and	_	_	_	_	_	_	_	_
144	28	_	_	_	_	_	_	_	_
145	DPI	_	_	_	_	_	_	_	_
146	.	_	_	_	_	_	_	_	_
147	Severe	_	_	_	_	_	_	_	BeginSeg=Yes
148	histological	_	_	_	_	_	_	_	_
149	lesions	_	_	_	_	_	_	_	_
150	were	_	_	_	_	_	_	_	_
151	observed	_	_	_	_	_	_	_	_
152	in	_	_	_	_	_	_	_	_
153	the	_	_	_	_	_	_	_	_
154	trachea	_	_	_	_	_	_	_	_
155	and	_	_	_	_	_	_	_	_
156	lung	_	_	_	_	_	_	_	_
157	while	_	_	_	_	_	_	_	BeginSeg=Yes
158	the	_	_	_	_	_	_	_	_
159	lesions	_	_	_	_	_	_	_	_
160	in	_	_	_	_	_	_	_	_
161	kidney	_	_	_	_	_	_	_	_
162	were	_	_	_	_	_	_	_	_
163	appeared	_	_	_	_	_	_	_	_
164	to	_	_	_	_	_	_	_	_
165	be	_	_	_	_	_	_	_	_
166	milder	_	_	_	_	_	_	_	_
167	.	_	_	_	_	_	_	_	_
168	Viral	_	_	_	_	_	_	_	BeginSeg=Yes
169	RNA	_	_	_	_	_	_	_	_
170	was	_	_	_	_	_	_	_	_
171	detected	_	_	_	_	_	_	_	_
172	in	_	_	_	_	_	_	_	_
173	all	_	_	_	_	_	_	_	_
174	tested	_	_	_	_	_	_	_	_
175	tissues	_	_	_	_	_	_	_	_
176	from	_	_	_	_	_	_	_	_
177	1	_	_	_	_	_	_	_	_
178	DPI	_	_	_	_	_	_	_	_
179	to	_	_	_	_	_	_	_	_
180	the	_	_	_	_	_	_	_	_
181	last	_	_	_	_	_	_	_	_
182	day	_	_	_	_	_	_	_	_
183	of	_	_	_	_	_	_	_	_
184	the	_	_	_	_	_	_	_	_
185	experiment	_	_	_	_	_	_	_	_
186	.	_	_	_	_	_	_	_	_
187	The	_	_	_	_	_	_	_	BeginSeg=Yes
188	highest	_	_	_	_	_	_	_	_
189	viral	_	_	_	_	_	_	_	_
190	load	_	_	_	_	_	_	_	_
191	was	_	_	_	_	_	_	_	_
192	measured	_	_	_	_	_	_	_	_
193	in	_	_	_	_	_	_	_	_
194	the	_	_	_	_	_	_	_	_
195	trachea	_	_	_	_	_	_	_	_
196	and	_	_	_	_	_	_	_	_
197	feces	_	_	_	_	_	_	_	_
198	on	_	_	_	_	_	_	_	_
199	1	_	_	_	_	_	_	_	_
200	st	_	_	_	_	_	_	_	_
201	and	_	_	_	_	_	_	_	_
202	5	_	_	_	_	_	_	_	_
203	th	_	_	_	_	_	_	_	_
204	DPI	_	_	_	_	_	_	_	_
205	,	_	_	_	_	_	_	_	_
206	respectively	_	_	_	_	_	_	_	_
207	.	_	_	_	_	_	_	_	_
208	It	_	_	_	_	_	_	_	BeginSeg=Yes
209	can	_	_	_	_	_	_	_	_
210	be	_	_	_	_	_	_	_	_
211	concluded	_	_	_	_	_	_	_	_
212	the	_	_	_	_	_	_	_	BeginSeg=Yes
213	IR-1	_	_	_	_	_	_	_	_
214	had	_	_	_	_	_	_	_	_
215	broad	_	_	_	_	_	_	_	_
216	tropism	_	_	_	_	_	_	_	_
217	for	_	_	_	_	_	_	_	_
218	respiratory	_	_	_	_	_	_	_	_
219	tract	_	_	_	_	_	_	_	_
220	,	_	_	_	_	_	_	_	_
221	digestive	_	_	_	_	_	_	_	_
222	system	_	_	_	_	_	_	_	_
223	,	_	_	_	_	_	_	_	_
224	and	_	_	_	_	_	_	_	_
225	renal	_	_	_	_	_	_	_	_
226	tissue	_	_	_	_	_	_	_	_
227	,	_	_	_	_	_	_	_	_
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229	its	_	_	_	_	_	_	_	_
230	epitheliotropic	_	_	_	_	_	_	_	_
231	nature	_	_	_	_	_	_	_	_
232	,	_	_	_	_	_	_	_	_
233	but	_	_	_	_	_	_	_	BeginSeg=Yes
234	it	_	_	_	_	_	_	_	_
235	caused	_	_	_	_	_	_	_	_
236	the	_	_	_	_	_	_	_	_
237	most	_	_	_	_	_	_	_	_
238	severe	_	_	_	_	_	_	_	_
239	lesions	_	_	_	_	_	_	_	_
240	in	_	_	_	_	_	_	_	_
241	the	_	_	_	_	_	_	_	_
242	respiratory	_	_	_	_	_	_	_	_
243	tract	_	_	_	_	_	_	_	_
244	.	_	_	_	_	_	_	_	_
245	This	_	_	_	_	_	_	_	BeginSeg=Yes
246	was	_	_	_	_	_	_	_	_
247	the	_	_	_	_	_	_	_	_
248	first	_	_	_	_	_	_	_	_
249	pathogenicity	_	_	_	_	_	_	_	_
250	study	_	_	_	_	_	_	_	_
251	of	_	_	_	_	_	_	_	_
252	Iranian	_	_	_	_	_	_	_	_
253	IR-1	_	_	_	_	_	_	_	_
254	IBV	_	_	_	_	_	_	_	_
255	.	_	_	_	_	_	_	_	_
256	Further	_	_	_	_	_	_	_	BeginSeg=Yes
257	knowledge	_	_	_	_	_	_	_	_
258	of	_	_	_	_	_	_	_	_
259	IBV	_	_	_	_	_	_	_	_
260	pathogenesis	_	_	_	_	_	_	_	_
261	provides	_	_	_	_	_	_	_	_
262	the	_	_	_	_	_	_	_	_
263	groundwork	_	_	_	_	_	_	_	_
264	to	_	_	_	_	_	_	_	BeginSeg=Yes
265	inform	_	_	_	_	_	_	_	_
266	more	_	_	_	_	_	_	_	_
267	effective	_	_	_	_	_	_	_	_
268	prevention	_	_	_	_	_	_	_	_
269	practices	_	_	_	_	_	_	_	_
270	.	_	_	_	_	_	_	_	_

# newdoc_id = 351fca8e4bd7321d75ec0227794deb0db3567540
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2	epidemic	_	_	_	_	_	_	_	_
3	diarrhea	_	_	_	_	_	_	_	_
4	virus	_	_	_	_	_	_	_	_
5	(	_	_	_	_	_	_	_	_
6	PEDV	_	_	_	_	_	_	_	_
7	)	_	_	_	_	_	_	_	_
8	,	_	_	_	_	_	_	_	_
9	which	_	_	_	_	_	_	_	BeginSeg=Yes
10	emerged	_	_	_	_	_	_	_	_
11	in	_	_	_	_	_	_	_	_
12	the	_	_	_	_	_	_	_	_
13	United	_	_	_	_	_	_	_	_
14	States	_	_	_	_	_	_	_	_
15	in	_	_	_	_	_	_	_	_
16	2013	_	_	_	_	_	_	_	_
17	,	_	_	_	_	_	_	_	_
18	has	_	_	_	_	_	_	_	BeginSeg=Yes
19	spread	_	_	_	_	_	_	_	_
20	throughout	_	_	_	_	_	_	_	_
21	North	_	_	_	_	_	_	_	_
22	America	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
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25	availability	_	_	_	_	_	_	_	_
26	of	_	_	_	_	_	_	_	_
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28	complete	_	_	_	_	_	_	_	_
29	genomes	_	_	_	_	_	_	_	_
30	worldwide	_	_	_	_	_	_	_	_
31	has	_	_	_	_	_	_	_	_
32	impeded	_	_	_	_	_	_	_	_
33	our	_	_	_	_	_	_	_	_
34	understanding	_	_	_	_	_	_	_	_
35	of	_	_	_	_	_	_	_	_
36	PEDV	_	_	_	_	_	_	_	_
37	introduction	_	_	_	_	_	_	_	_
38	into	_	_	_	_	_	_	_	_
39	the	_	_	_	_	_	_	_	_
40	United	_	_	_	_	_	_	_	_
41	States	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
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44	determine	_	_	_	_	_	_	_	_
45	the	_	_	_	_	_	_	_	_
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47	between	_	_	_	_	_	_	_	_
48	the	_	_	_	_	_	_	_	_
49	North	_	_	_	_	_	_	_	_
50	American	_	_	_	_	_	_	_	_
51	strains	_	_	_	_	_	_	_	_
52	and	_	_	_	_	_	_	_	_
53	global	_	_	_	_	_	_	_	_
54	emerging	_	_	_	_	_	_	_	_
55	and	_	_	_	_	_	_	_	_
56	historic	_	_	_	_	_	_	_	_
57	PEDV	_	_	_	_	_	_	_	_
58	strains	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	we	_	_	_	_	_	_	_	BeginSeg=Yes
61	sequenced	_	_	_	_	_	_	_	_
62	and	_	_	_	_	_	_	_	_
63	analyzed	_	_	_	_	_	_	_	_
64	complete	_	_	_	_	_	_	_	_
65	genomes	_	_	_	_	_	_	_	_
66	of	_	_	_	_	_	_	_	_
67	74	_	_	_	_	_	_	_	_
68	strains	_	_	_	_	_	_	_	_
69	from	_	_	_	_	_	_	_	_
70	North	_	_	_	_	_	_	_	_
71	America	_	_	_	_	_	_	_	_
72	;	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	BeginSeg=Yes
74	strains	_	_	_	_	_	_	_	_
75	clustered	_	_	_	_	_	_	_	_
76	into	_	_	_	_	_	_	_	_
77	2	_	_	_	_	_	_	_	_
78	distinct	_	_	_	_	_	_	_	_
79	clades	_	_	_	_	_	_	_	_
80	.	_	_	_	_	_	_	_	_
81	Compared	_	_	_	_	_	_	_	BeginSeg=Yes
82	with	_	_	_	_	_	_	_	_
83	the	_	_	_	_	_	_	_	_
84	initially	_	_	_	_	_	_	_	_
85	reported	_	_	_	_	_	_	_	_
86	virulent	_	_	_	_	_	_	_	_
87	US	_	_	_	_	_	_	_	_
88	PEDV	_	_	_	_	_	_	_	_
89	strains	_	_	_	_	_	_	_	_
90	,	_	_	_	_	_	_	_	_
91	7	_	_	_	_	_	_	_	BeginSeg=Yes
92	(	_	_	_	_	_	_	_	BeginSeg=Yes
93	9.7	_	_	_	_	_	_	_	_
94	%	_	_	_	_	_	_	_	_
95	)	_	_	_	_	_	_	_	_
96	strains	_	_	_	_	_	_	_	BeginSeg=Yes
97	from	_	_	_	_	_	_	_	_
98	4	_	_	_	_	_	_	_	_
99	states	_	_	_	_	_	_	_	_
100	contained	_	_	_	_	_	_	_	_
101	insertions	_	_	_	_	_	_	_	_
102	and	_	_	_	_	_	_	_	_
103	deletions	_	_	_	_	_	_	_	_
104	in	_	_	_	_	_	_	_	_
105	the	_	_	_	_	_	_	_	_
106	spike	_	_	_	_	_	_	_	_
107	gene	_	_	_	_	_	_	_	_
108	(	_	_	_	_	_	_	_	_
109	S	_	_	_	_	_	_	_	_
110	INDELs	_	_	_	_	_	_	_	_
111	)	_	_	_	_	_	_	_	_
112	.	_	_	_	_	_	_	_	_
113	These	_	_	_	_	_	_	_	BeginSeg=Yes
114	S	_	_	_	_	_	_	_	_
115	INDEL	_	_	_	_	_	_	_	_
116	strains	_	_	_	_	_	_	_	_
117	share	_	_	_	_	_	_	_	_
118	99.8%-100	_	_	_	_	_	_	_	_
119	%	_	_	_	_	_	_	_	_
120	nt	_	_	_	_	_	_	_	_
121	identity	_	_	_	_	_	_	_	_
122	with	_	_	_	_	_	_	_	_
123	each	_	_	_	_	_	_	_	_
124	other	_	_	_	_	_	_	_	_
125	and	_	_	_	_	_	_	_	_
126	96.2%-96.7	_	_	_	_	_	_	_	_
127	%	_	_	_	_	_	_	_	_
128	nt	_	_	_	_	_	_	_	_
129	identity	_	_	_	_	_	_	_	_
130	with	_	_	_	_	_	_	_	_
131	the	_	_	_	_	_	_	_	_
132	initial	_	_	_	_	_	_	_	_
133	US	_	_	_	_	_	_	_	_
134	strains	_	_	_	_	_	_	_	_
135	.	_	_	_	_	_	_	_	_
136	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
137	,	_	_	_	_	_	_	_	_
138	the	_	_	_	_	_	_	_	_
139	S	_	_	_	_	_	_	_	_
140	IN	_	_	_	_	_	_	_	_
141	-	_	_	_	_	_	_	_	_
142	DEL	_	_	_	_	_	_	_	_
143	strains	_	_	_	_	_	_	_	_
144	form	_	_	_	_	_	_	_	_
145	a	_	_	_	_	_	_	_	_
146	distinct	_	_	_	_	_	_	_	_
147	cluster	_	_	_	_	_	_	_	_
148	within	_	_	_	_	_	_	_	_
149	North	_	_	_	_	_	_	_	_
150	American	_	_	_	_	_	_	_	_
151	clade	_	_	_	_	_	_	_	_
152	II	_	_	_	_	_	_	_	_
153	,	_	_	_	_	_	_	_	_
154	sharing	_	_	_	_	_	_	_	_
155	98.6%-100	_	_	_	_	_	_	_	_
156	%	_	_	_	_	_	_	_	_
157	nt	_	_	_	_	_	_	_	_
158	identity	_	_	_	_	_	_	_	_
159	overall	_	_	_	_	_	_	_	_
160	.	_	_	_	_	_	_	_	_
161	In	_	_	_	_	_	_	_	BeginSeg=Yes
162	the	_	_	_	_	_	_	_	_
163	United	_	_	_	_	_	_	_	_
164	States	_	_	_	_	_	_	_	_
165	,	_	_	_	_	_	_	_	_
166	the	_	_	_	_	_	_	_	_
167	S	_	_	_	_	_	_	_	_
168	INDEL	_	_	_	_	_	_	_	_
169	and	_	_	_	_	_	_	_	_
170	original	_	_	_	_	_	_	_	_
171	PEDV	_	_	_	_	_	_	_	_
172	strains	_	_	_	_	_	_	_	_
173	are	_	_	_	_	_	_	_	_
174	cocirculating	_	_	_	_	_	_	_	_
175	and	_	_	_	_	_	_	_	BeginSeg=Yes
176	could	_	_	_	_	_	_	_	_
177	have	_	_	_	_	_	_	_	_
178	been	_	_	_	_	_	_	_	_
179	introduced	_	_	_	_	_	_	_	_
180	simultaneously	_	_	_	_	_	_	_	_
181	.	_	_	_	_	_	_	_	_

# newdoc_id = 36d1ce29e9a96454ecd03db6c5e970052cb82abb
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2	this	_	_	_	_	_	_	_	_
3	study	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	the	_	_	_	_	_	_	_	_
6	susceptibility	_	_	_	_	_	_	_	_
7	of	_	_	_	_	_	_	_	_
8	porcine	_	_	_	_	_	_	_	_
9	peripheral	_	_	_	_	_	_	_	_
10	blood	_	_	_	_	_	_	_	_
11	monocytes	_	_	_	_	_	_	_	_
12	(	_	_	_	_	_	_	_	_
13	BMo	_	_	_	_	_	_	_	_
14	)	_	_	_	_	_	_	_	_
15	,	_	_	_	_	_	_	_	_
16	peritoneal	_	_	_	_	_	_	_	_
17	macrophages	_	_	_	_	_	_	_	_
18	(	_	_	_	_	_	_	_	_
19	PMf	_	_	_	_	_	_	_	_
20	)	_	_	_	_	_	_	_	_
21	and	_	_	_	_	_	_	_	_
22	alveolar	_	_	_	_	_	_	_	_
23	macrophages	_	_	_	_	_	_	_	_
24	(	_	_	_	_	_	_	_	_
25	AMf	_	_	_	_	_	_	_	_
26	)	_	_	_	_	_	_	_	_
27	to	_	_	_	_	_	_	_	_
28	PRRSV	_	_	_	_	_	_	_	_
29	was	_	_	_	_	_	_	_	_
30	examined	_	_	_	_	_	_	_	_
31	.	_	_	_	_	_	_	_	_
32	To	_	_	_	_	_	_	_	BeginSeg=Yes
33	test	_	_	_	_	_	_	_	_
34	the	_	_	_	_	_	_	_	_
35	effect	_	_	_	_	_	_	_	_
36	of	_	_	_	_	_	_	_	_
37	differentiation	_	_	_	_	_	_	_	_
38	and	_	_	_	_	_	_	_	_
39	activation	_	_	_	_	_	_	_	_
40	on	_	_	_	_	_	_	_	_
41	their	_	_	_	_	_	_	_	_
42	susceptibility	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	AMf	_	_	_	_	_	_	_	BeginSeg=Yes
45	and	_	_	_	_	_	_	_	_
46	BMo	_	_	_	_	_	_	_	_
47	were	_	_	_	_	_	_	_	_
48	aged	_	_	_	_	_	_	_	_
49	,	_	_	_	_	_	_	_	_
50	cultivated	_	_	_	_	_	_	_	BeginSeg=Yes
51	in	_	_	_	_	_	_	_	_
52	either	_	_	_	_	_	_	_	_
53	adhesion	_	_	_	_	_	_	_	_
54	or	_	_	_	_	_	_	_	_
55	suspension	_	_	_	_	_	_	_	_
56	and	_	_	_	_	_	_	_	BeginSeg=Yes
57	treated	_	_	_	_	_	_	_	_
58	with	_	_	_	_	_	_	_	_
59	bacterial	_	_	_	_	_	_	_	_
60	lipopolysaccharide	_	_	_	_	_	_	_	_
61	(	_	_	_	_	_	_	_	_
62	LPS	_	_	_	_	_	_	_	_
63	)	_	_	_	_	_	_	_	_
64	and	_	_	_	_	_	_	_	_
65	phorbol	_	_	_	_	_	_	_	_
66	myristate	_	_	_	_	_	_	_	_
67	acetate	_	_	_	_	_	_	_	_
68	(	_	_	_	_	_	_	_	_
69	PMA	_	_	_	_	_	_	_	_
70	)	_	_	_	_	_	_	_	_
71	.	_	_	_	_	_	_	_	_
72	It	_	_	_	_	_	_	_	BeginSeg=Yes
73	was	_	_	_	_	_	_	_	_
74	found	_	_	_	_	_	_	_	_
75	that	_	_	_	_	_	_	_	_
76	freshly	_	_	_	_	_	_	_	_
77	isolated	_	_	_	_	_	_	_	_
78	PMf	_	_	_	_	_	_	_	_
79	and	_	_	_	_	_	_	_	_
80	BMo	_	_	_	_	_	_	_	_
81	were	_	_	_	_	_	_	_	_
82	non	_	_	_	_	_	_	_	_
83	-	_	_	_	_	_	_	_	_
84	permissive	_	_	_	_	_	_	_	_
85	to	_	_	_	_	_	_	_	_
86	PRRSV	_	_	_	_	_	_	_	_
87	.	_	_	_	_	_	_	_	_
88	PMf	_	_	_	_	_	_	_	BeginSeg=Yes
89	remained	_	_	_	_	_	_	_	_
90	refractory	_	_	_	_	_	_	_	_
91	but	_	_	_	_	_	_	_	BeginSeg=Yes
92	a	_	_	_	_	_	_	_	_
93	few	_	_	_	_	_	_	_	_
94	BMo	_	_	_	_	_	_	_	_
95	became	_	_	_	_	_	_	_	_
96	susceptible	_	_	_	_	_	_	_	_
97	after	_	_	_	_	_	_	_	_
98	1	_	_	_	_	_	_	_	_
99	day	_	_	_	_	_	_	_	_
100	cultivation	_	_	_	_	_	_	_	_
101	.	_	_	_	_	_	_	_	_
102	AMf	_	_	_	_	_	_	_	BeginSeg=Yes
103	were	_	_	_	_	_	_	_	_
104	permissive	_	_	_	_	_	_	_	_
105	with	_	_	_	_	_	_	_	_
106	a	_	_	_	_	_	_	_	_
107	significant	_	_	_	_	_	_	_	_
108	increase	_	_	_	_	_	_	_	_
109	of	_	_	_	_	_	_	_	_
110	their	_	_	_	_	_	_	_	_
111	susceptibility	_	_	_	_	_	_	_	_
112	after	_	_	_	_	_	_	_	_
113	one	_	_	_	_	_	_	_	_
114	day	_	_	_	_	_	_	_	_
115	cultivation	_	_	_	_	_	_	_	_
116	.	_	_	_	_	_	_	_	_
117	In	_	_	_	_	_	_	_	BeginSeg=Yes
118	a	_	_	_	_	_	_	_	_
119	binding	_	_	_	_	_	_	_	_
120	assay	_	_	_	_	_	_	_	_
121	,	_	_	_	_	_	_	_	_
122	it	_	_	_	_	_	_	_	_
123	was	_	_	_	_	_	_	_	_
124	demonstrated	_	_	_	_	_	_	_	_
125	that	_	_	_	_	_	_	_	_
126	the	_	_	_	_	_	_	_	_
127	attachment	_	_	_	_	_	_	_	_
128	of	_	_	_	_	_	_	_	_
129	biotinylated	_	_	_	_	_	_	_	_
130	PRRSV	_	_	_	_	_	_	_	_
131	to	_	_	_	_	_	_	_	_
132	AMf	_	_	_	_	_	_	_	_
133	is	_	_	_	_	_	_	_	_
134	much	_	_	_	_	_	_	_	_
135	more	_	_	_	_	_	_	_	_
136	efficient	_	_	_	_	_	_	_	_
137	than	_	_	_	_	_	_	_	_
138	to	_	_	_	_	_	_	_	_
139	PMf	_	_	_	_	_	_	_	_
140	and	_	_	_	_	_	_	_	_
141	BMo	_	_	_	_	_	_	_	_
142	.	_	_	_	_	_	_	_	_
143	Two	_	_	_	_	_	_	_	BeginSeg=Yes
144	monoclonal	_	_	_	_	_	_	_	_
145	antibodies	_	_	_	_	_	_	_	_
146	(	_	_	_	_	_	_	_	_
147	Mabs	_	_	_	_	_	_	_	_
148	)	_	_	_	_	_	_	_	_
149	41D3	_	_	_	_	_	_	_	_
150	and	_	_	_	_	_	_	_	_
151	41D5	_	_	_	_	_	_	_	_
152	which	_	_	_	_	_	_	_	BeginSeg=Yes
153	block	_	_	_	_	_	_	_	_
154	PRRSV	_	_	_	_	_	_	_	_
155	infection	_	_	_	_	_	_	_	_
156	of	_	_	_	_	_	_	_	_
157	AMf	_	_	_	_	_	_	_	_
158	and	_	_	_	_	_	_	_	BeginSeg=Yes
159	are	_	_	_	_	_	_	_	_
160	directed	_	_	_	_	_	_	_	_
161	against	_	_	_	_	_	_	_	_
162	a	_	_	_	_	_	_	_	_
163	candidate	_	_	_	_	_	_	_	_
164	receptor	_	_	_	_	_	_	_	_
165	for	_	_	_	_	_	_	_	_
166	PRRSV	_	_	_	_	_	_	_	_
167	only	_	_	_	_	_	_	_	BeginSeg=Yes
168	reacted	_	_	_	_	_	_	_	_
169	with	_	_	_	_	_	_	_	_
170	the	_	_	_	_	_	_	_	_
171	cell	_	_	_	_	_	_	_	_
172	membrane	_	_	_	_	_	_	_	_
173	of	_	_	_	_	_	_	_	_
174	AMf	_	_	_	_	_	_	_	_
175	.	_	_	_	_	_	_	_	_
176	PMA	_	_	_	_	_	_	_	BeginSeg=Yes
177	treatment	_	_	_	_	_	_	_	_
178	of	_	_	_	_	_	_	_	_
179	AMf	_	_	_	_	_	_	_	_
180	blocked	_	_	_	_	_	_	_	_
181	PRRSV	_	_	_	_	_	_	_	_
182	replication	_	_	_	_	_	_	_	_
183	in	_	_	_	_	_	_	_	_
184	the	_	_	_	_	_	_	_	_
185	cells	_	_	_	_	_	_	_	_
186	in	_	_	_	_	_	_	_	_
187	a	_	_	_	_	_	_	_	_
188	dose	_	_	_	_	_	_	_	_
189	-	_	_	_	_	_	_	_	_
190	dependent	_	_	_	_	_	_	_	_
191	manner	_	_	_	_	_	_	_	_
192	.	_	_	_	_	_	_	_	_
193	The	_	_	_	_	_	_	_	BeginSeg=Yes
194	blocking	_	_	_	_	_	_	_	_
195	effect	_	_	_	_	_	_	_	_
196	of	_	_	_	_	_	_	_	_
197	PMA	_	_	_	_	_	_	_	_
198	decreased	_	_	_	_	_	_	_	_
199	after	_	_	_	_	_	_	_	_
200	9	_	_	_	_	_	_	_	_
201	h	_	_	_	_	_	_	_	_
202	continuous	_	_	_	_	_	_	_	_
203	pre	_	_	_	_	_	_	_	_
204	-	_	_	_	_	_	_	_	_
205	treatment	_	_	_	_	_	_	_	_
206	and	_	_	_	_	_	_	_	BeginSeg=Yes
207	diminished	_	_	_	_	_	_	_	_
208	after	_	_	_	_	_	_	_	_
209	24	_	_	_	_	_	_	_	_
210	h	_	_	_	_	_	_	_	_
211	continuous	_	_	_	_	_	_	_	_
212	pre	_	_	_	_	_	_	_	_
213	-	_	_	_	_	_	_	_	_
214	treatment	_	_	_	_	_	_	_	_
215	.	_	_	_	_	_	_	_	_
216	PMA	_	_	_	_	_	_	_	BeginSeg=Yes
217	treatment	_	_	_	_	_	_	_	_
218	did	_	_	_	_	_	_	_	_
219	not	_	_	_	_	_	_	_	_
220	affect	_	_	_	_	_	_	_	_
221	the	_	_	_	_	_	_	_	_
222	binding	_	_	_	_	_	_	_	_
223	of	_	_	_	_	_	_	_	_
224	PRRSV	_	_	_	_	_	_	_	_
225	and	_	_	_	_	_	_	_	_
226	MAb	_	_	_	_	_	_	_	_
227	41D3	_	_	_	_	_	_	_	_
228	and	_	_	_	_	_	_	_	_
229	41D5	_	_	_	_	_	_	_	_
230	to	_	_	_	_	_	_	_	_
231	AMf	_	_	_	_	_	_	_	_
232	.	_	_	_	_	_	_	_	_
233	Direct	_	_	_	_	_	_	_	BeginSeg=Yes
234	or	_	_	_	_	_	_	_	_
235	indirect	_	_	_	_	_	_	_	_
236	treatment	_	_	_	_	_	_	_	_
237	of	_	_	_	_	_	_	_	_
238	AMf	_	_	_	_	_	_	_	_
239	and	_	_	_	_	_	_	_	_
240	BMo	_	_	_	_	_	_	_	_
241	with	_	_	_	_	_	_	_	_
242	LPS	_	_	_	_	_	_	_	_
243	or	_	_	_	_	_	_	_	_
244	cultivation	_	_	_	_	_	_	_	_
245	in	_	_	_	_	_	_	_	_
246	suspension	_	_	_	_	_	_	_	_
247	did	_	_	_	_	_	_	_	_
248	not	_	_	_	_	_	_	_	_
249	significantly	_	_	_	_	_	_	_	_
250	affect	_	_	_	_	_	_	_	_
251	their	_	_	_	_	_	_	_	_
252	susceptibility	_	_	_	_	_	_	_	_
253	.	_	_	_	_	_	_	_	_
254	These	_	_	_	_	_	_	_	BeginSeg=Yes
255	results	_	_	_	_	_	_	_	_
256	provide	_	_	_	_	_	_	_	_
257	clear	_	_	_	_	_	_	_	_
258	evidence	_	_	_	_	_	_	_	_
259	that	_	_	_	_	_	_	_	BeginSeg=Yes
260	PRRSV	_	_	_	_	_	_	_	_
261	has	_	_	_	_	_	_	_	_
262	a	_	_	_	_	_	_	_	_
263	strongly	_	_	_	_	_	_	_	_
264	restricted	_	_	_	_	_	_	_	_
265	tropism	_	_	_	_	_	_	_	_
266	for	_	_	_	_	_	_	_	_
267	only	_	_	_	_	_	_	_	_
268	some	_	_	_	_	_	_	_	_
269	sub	_	_	_	_	_	_	_	_
270	-	_	_	_	_	_	_	_	_
271	populations	_	_	_	_	_	_	_	_
272	of	_	_	_	_	_	_	_	_
273	porcine	_	_	_	_	_	_	_	_
274	monocytes	_	_	_	_	_	_	_	_
275	/	_	_	_	_	_	_	_	_
276	macrophages	_	_	_	_	_	_	_	_
277	and	_	_	_	_	_	_	_	BeginSeg=Yes
278	that	_	_	_	_	_	_	_	_
279	some	_	_	_	_	_	_	_	_
280	specific	_	_	_	_	_	_	_	_
281	states	_	_	_	_	_	_	_	_
282	of	_	_	_	_	_	_	_	_
283	differentiation	_	_	_	_	_	_	_	_
284	and	_	_	_	_	_	_	_	_
285	activation	_	_	_	_	_	_	_	_
286	of	_	_	_	_	_	_	_	_
287	monocytes	_	_	_	_	_	_	_	_
288	/	_	_	_	_	_	_	_	_
289	macrophages	_	_	_	_	_	_	_	_
290	considerably	_	_	_	_	_	_	_	_
291	affect	_	_	_	_	_	_	_	_
292	their	_	_	_	_	_	_	_	_
293	susceptibility	_	_	_	_	_	_	_	_
294	.	_	_	_	_	_	_	_	_

# newdoc_id = 3835ee8683c9c63e71a30ea92a36903117d467b9
1	As	_	_	_	_	_	_	_	BeginSeg=Yes
2	the	_	_	_	_	_	_	_	_
3	ongoing	_	_	_	_	_	_	_	_
4	COVID-19	_	_	_	_	_	_	_	_
5	pandemic	_	_	_	_	_	_	_	_
6	posed	_	_	_	_	_	_	_	_
7	a	_	_	_	_	_	_	_	_
8	huge	_	_	_	_	_	_	_	_
9	challenge	_	_	_	_	_	_	_	_
10	to	_	_	_	_	_	_	_	_
11	global	_	_	_	_	_	_	_	_
12	public	_	_	_	_	_	_	_	_
13	health	_	_	_	_	_	_	_	_
14	,	_	_	_	_	_	_	_	_
15	emphasis	_	_	_	_	_	_	_	BeginSeg=Yes
16	on	_	_	_	_	_	_	_	_
17	personal	_	_	_	_	_	_	_	_
18	hygiene	_	_	_	_	_	_	_	_
19	caused	_	_	_	_	_	_	_	_
20	extraordinary	_	_	_	_	_	_	_	_
21	daily	_	_	_	_	_	_	_	_
22	use	_	_	_	_	_	_	_	_
23	of	_	_	_	_	_	_	_	_
24	detergents	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	household	_	_	_	_	_	_	_	_
27	cleaning	_	_	_	_	_	_	_	_
28	products	_	_	_	_	_	_	_	_
29	.	_	_	_	_	_	_	_	_
30	Since	_	_	_	_	_	_	_	BeginSeg=Yes
31	antibacterial	_	_	_	_	_	_	_	_
32	cleaning	_	_	_	_	_	_	_	_
33	products	_	_	_	_	_	_	_	_
34	have	_	_	_	_	_	_	_	_
35	the	_	_	_	_	_	_	_	_
36	capacity	_	_	_	_	_	_	_	_
37	to	_	_	_	_	_	_	_	BeginSeg=Yes
38	change	_	_	_	_	_	_	_	_
39	the	_	_	_	_	_	_	_	_
40	environmental	_	_	_	_	_	_	_	_
41	microbiome	_	_	_	_	_	_	_	_
42	,	_	_	_	_	_	_	_	_
43	increased	_	_	_	_	_	_	_	BeginSeg=Yes
44	exposure	_	_	_	_	_	_	_	_
45	to	_	_	_	_	_	_	_	_
46	household	_	_	_	_	_	_	_	_
47	disinfectants	_	_	_	_	_	_	_	_
48	could	_	_	_	_	_	_	_	_
49	be	_	_	_	_	_	_	_	_
50	associated	_	_	_	_	_	_	_	_
51	with	_	_	_	_	_	_	_	_
52	alterations	_	_	_	_	_	_	_	_
53	in	_	_	_	_	_	_	_	_
54	human	_	_	_	_	_	_	_	_
55	microbiota	_	_	_	_	_	_	_	_
56	composition	_	_	_	_	_	_	_	_
57	and	_	_	_	_	_	_	_	_
58	function	_	_	_	_	_	_	_	_
59	.	_	_	_	_	_	_	_	_
60	Moreover	_	_	_	_	_	_	_	BeginSeg=Yes
61	,	_	_	_	_	_	_	_	_
62	the	_	_	_	_	_	_	_	_
63	emerging	_	_	_	_	_	_	_	_
64	links	_	_	_	_	_	_	_	_
65	between	_	_	_	_	_	_	_	_
66	household	_	_	_	_	_	_	_	_
67	cleaning	_	_	_	_	_	_	_	_
68	products	_	_	_	_	_	_	_	_
69	and	_	_	_	_	_	_	_	_
70	occurrence	_	_	_	_	_	_	_	_
71	of	_	_	_	_	_	_	_	_
72	non	_	_	_	_	_	_	_	_
73	-	_	_	_	_	_	_	_	_
74	communicable	_	_	_	_	_	_	_	_
75	diseases	_	_	_	_	_	_	_	_
76	and	_	_	_	_	_	_	_	_
77	antibiotic	_	_	_	_	_	_	_	_
78	resistance	_	_	_	_	_	_	_	_
79	may	_	_	_	_	_	_	_	_
80	involve	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	gut	_	_	_	_	_	_	_	_
83	microbiome	_	_	_	_	_	_	_	_
84	.	_	_	_	_	_	_	_	_
85	The	_	_	_	_	_	_	_	BeginSeg=Yes
86	mediating	_	_	_	_	_	_	_	_
87	effects	_	_	_	_	_	_	_	_
88	of	_	_	_	_	_	_	_	_
89	disturbed	_	_	_	_	_	_	_	_
90	gut	_	_	_	_	_	_	_	_
91	microbiota	_	_	_	_	_	_	_	_
92	on	_	_	_	_	_	_	_	_
93	associations	_	_	_	_	_	_	_	_
94	between	_	_	_	_	_	_	_	_
95	home	_	_	_	_	_	_	_	_
96	use	_	_	_	_	_	_	_	_
97	of	_	_	_	_	_	_	_	_
98	cleaning	_	_	_	_	_	_	_	_
99	products	_	_	_	_	_	_	_	_
100	and	_	_	_	_	_	_	_	_
101	life	_	_	_	_	_	_	_	_
102	-	_	_	_	_	_	_	_	_
103	long	_	_	_	_	_	_	_	_
104	health	_	_	_	_	_	_	_	_
105	consequences	_	_	_	_	_	_	_	_
106	have	_	_	_	_	_	_	_	_
107	been	_	_	_	_	_	_	_	_
108	documented	_	_	_	_	_	_	_	_
109	in	_	_	_	_	_	_	_	_
110	some	_	_	_	_	_	_	_	_
111	observational	_	_	_	_	_	_	_	_
112	studies	_	_	_	_	_	_	_	_
113	.	_	_	_	_	_	_	_	_
114	Regarding	_	_	_	_	_	_	_	BeginSeg=Yes
115	the	_	_	_	_	_	_	_	_
116	evidence	_	_	_	_	_	_	_	_
117	associated	_	_	_	_	_	_	_	_
118	reduction	_	_	_	_	_	_	_	_
119	in	_	_	_	_	_	_	_	_
120	exposure	_	_	_	_	_	_	_	_
121	to	_	_	_	_	_	_	_	_
122	non	_	_	_	_	_	_	_	_
123	-	_	_	_	_	_	_	_	_
124	pathogenic	_	_	_	_	_	_	_	_
125	commensal	_	_	_	_	_	_	_	_
126	bacteria	_	_	_	_	_	_	_	_
127	and	_	_	_	_	_	_	_	_
128	gut	_	_	_	_	_	_	_	_
129	dysbiosis	_	_	_	_	_	_	_	_
130	,	_	_	_	_	_	_	_	_
131	further	_	_	_	_	_	_	_	BeginSeg=Yes
132	study	_	_	_	_	_	_	_	_
133	is	_	_	_	_	_	_	_	_
134	required	_	_	_	_	_	_	_	_
135	to	_	_	_	_	_	_	_	BeginSeg=Yes
136	assess	_	_	_	_	_	_	_	_
137	the	_	_	_	_	_	_	_	_
138	effect	_	_	_	_	_	_	_	_
139	of	_	_	_	_	_	_	_	_
140	massive	_	_	_	_	_	_	_	_
141	use	_	_	_	_	_	_	_	_
142	of	_	_	_	_	_	_	_	_
143	cleaning	_	_	_	_	_	_	_	_
144	products	_	_	_	_	_	_	_	_
145	during	_	_	_	_	_	_	_	_
146	COVID-19	_	_	_	_	_	_	_	_
147	pandemic	_	_	_	_	_	_	_	_
148	on	_	_	_	_	_	_	_	_
149	long	_	_	_	_	_	_	_	_
150	-	_	_	_	_	_	_	_	_
151	term	_	_	_	_	_	_	_	_
152	host	_	_	_	_	_	_	_	_
153	health	_	_	_	_	_	_	_	_
154	mediated	_	_	_	_	_	_	_	BeginSeg=Yes
155	by	_	_	_	_	_	_	_	_
156	the	_	_	_	_	_	_	_	_
157	altered	_	_	_	_	_	_	_	_
158	microbiota	_	_	_	_	_	_	_	_
159	.	_	_	_	_	_	_	_	_
160	In	_	_	_	_	_	_	_	BeginSeg=Yes
161	this	_	_	_	_	_	_	_	_
162	context	_	_	_	_	_	_	_	_
163	,	_	_	_	_	_	_	_	_
164	recommendations	_	_	_	_	_	_	_	_
165	to	_	_	_	_	_	_	_	BeginSeg=Yes
166	consume	_	_	_	_	_	_	_	_
167	probiotics	_	_	_	_	_	_	_	_
168	and	_	_	_	_	_	_	_	_
169	fermented	_	_	_	_	_	_	_	_
170	foods	_	_	_	_	_	_	_	_
171	might	_	_	_	_	_	_	_	BeginSeg=Yes
172	reverse	_	_	_	_	_	_	_	_
173	the	_	_	_	_	_	_	_	_
174	consequences	_	_	_	_	_	_	_	_
175	by	_	_	_	_	_	_	_	BeginSeg=Yes
176	alleviating	_	_	_	_	_	_	_	_
177	dysbiosis	_	_	_	_	_	_	_	_
178	.	_	_	_	_	_	_	_	_

# newdoc_id = 38824de74c353c895d96ee1a20ce43956363ff9b
1	Viruses	_	_	_	_	_	_	_	BeginSeg=Yes
2	use	_	_	_	_	_	_	_	_
3	cell	_	_	_	_	_	_	_	_
4	machinery	_	_	_	_	_	_	_	_
5	to	_	_	_	_	_	_	_	BeginSeg=Yes
6	replicate	_	_	_	_	_	_	_	_
7	their	_	_	_	_	_	_	_	_
8	genome	_	_	_	_	_	_	_	_
9	and	_	_	_	_	_	_	_	BeginSeg=Yes
10	produce	_	_	_	_	_	_	_	_
11	viral	_	_	_	_	_	_	_	_
12	proteins	_	_	_	_	_	_	_	_
13	.	_	_	_	_	_	_	_	_
14	For	_	_	_	_	_	_	_	BeginSeg=Yes
15	this	_	_	_	_	_	_	_	_
16	reason	_	_	_	_	_	_	_	_
17	,	_	_	_	_	_	_	_	_
18	several	_	_	_	_	_	_	_	_
19	intracellular	_	_	_	_	_	_	_	_
20	factors	_	_	_	_	_	_	_	_
21	,	_	_	_	_	_	_	_	_
22	including	_	_	_	_	_	_	_	BeginSeg=Yes
23	the	_	_	_	_	_	_	_	_
24	redox	_	_	_	_	_	_	_	_
25	state	_	_	_	_	_	_	_	_
26	,	_	_	_	_	_	_	_	_
27	might	_	_	_	_	_	_	_	BeginSeg=Yes
28	directly	_	_	_	_	_	_	_	_
29	or	_	_	_	_	_	_	_	_
30	indirectly	_	_	_	_	_	_	_	_
31	affect	_	_	_	_	_	_	_	_
32	the	_	_	_	_	_	_	_	_
33	progression	_	_	_	_	_	_	_	_
34	and	_	_	_	_	_	_	_	_
35	outcome	_	_	_	_	_	_	_	_
36	of	_	_	_	_	_	_	_	_
37	viral	_	_	_	_	_	_	_	_
38	infection	_	_	_	_	_	_	_	_
39	.	_	_	_	_	_	_	_	_
40	In	_	_	_	_	_	_	_	BeginSeg=Yes
41	physiological	_	_	_	_	_	_	_	_
42	conditions	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	the	_	_	_	_	_	_	_	_
45	redox	_	_	_	_	_	_	_	_
46	balance	_	_	_	_	_	_	_	_
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213	by	_	_	_	_	_	_	_	_
214	a	_	_	_	_	_	_	_	_
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218	,	_	_	_	_	_	_	_	_
219	like	_	_	_	_	_	_	_	_
220	COVID-19	_	_	_	_	_	_	_	_
221	.	_	_	_	_	_	_	_	_

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201	in	_	_	_	_	_	_	_	_
202	the	_	_	_	_	_	_	_	_
203	elderly	_	_	_	_	_	_	_	_
204	.	_	_	_	_	_	_	_	_

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3	work	_	_	_	_	_	_	_	_
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12	and	_	_	_	_	_	_	_	_
13	spread	_	_	_	_	_	_	_	_
14	of	_	_	_	_	_	_	_	_
15	coronavirus	_	_	_	_	_	_	_	_
16	disease	_	_	_	_	_	_	_	_
17	2019	_	_	_	_	_	_	_	_
18	or	_	_	_	_	_	_	_	_
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20	.	_	_	_	_	_	_	_	_
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22	model	_	_	_	_	_	_	_	_
23	features	_	_	_	_	_	_	_	_
24	delay	_	_	_	_	_	_	_	_
25	terms	_	_	_	_	_	_	_	_
26	to	_	_	_	_	_	_	_	BeginSeg=Yes
27	account	_	_	_	_	_	_	_	_
28	for	_	_	_	_	_	_	_	_
29	(	_	_	_	_	_	_	_	_
30	a	_	_	_	_	_	_	_	_
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33	time	_	_	_	_	_	_	_	_
34	lapse	_	_	_	_	_	_	_	_
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36	latency	_	_	_	_	_	_	_	_
37	period	_	_	_	_	_	_	_	_
38	between	_	_	_	_	_	_	_	_
39	contracting	_	_	_	_	_	_	_	_
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41	disease	_	_	_	_	_	_	_	_
42	and	_	_	_	_	_	_	_	_
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46	and	_	_	_	_	_	_	_	_
47	(	_	_	_	_	_	_	_	_
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51	time	_	_	_	_	_	_	_	_
52	lag	_	_	_	_	_	_	_	_
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54	testing	_	_	_	_	_	_	_	_
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57	the	_	_	_	_	_	_	_	_
58	virus	_	_	_	_	_	_	_	_
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60	to	_	_	_	_	_	_	_	_
61	the	_	_	_	_	_	_	_	_
62	limited	_	_	_	_	_	_	_	_
63	numbers	_	_	_	_	_	_	_	_
64	of	_	_	_	_	_	_	_	_
65	testing	_	_	_	_	_	_	_	_
66	facilities	_	_	_	_	_	_	_	_
67	currently	_	_	_	_	_	_	_	_
68	available	_	_	_	_	_	_	_	_
69	.	_	_	_	_	_	_	_	_
70	We	_	_	_	_	_	_	_	BeginSeg=Yes
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75	introduces	_	_	_	_	_	_	_	_
76	a	_	_	_	_	_	_	_	_
77	significant	_	_	_	_	_	_	_	_
78	disparity	_	_	_	_	_	_	_	_
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80	the	_	_	_	_	_	_	_	_
81	actual	_	_	_	_	_	_	_	_
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83	reported	_	_	_	_	_	_	_	_
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86	trajectories	_	_	_	_	_	_	_	_
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88	cases	_	_	_	_	_	_	_	_
89	in	_	_	_	_	_	_	_	_
90	a	_	_	_	_	_	_	_	_
91	particular	_	_	_	_	_	_	_	_
92	region	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_
94	Specifically	_	_	_	_	_	_	_	BeginSeg=Yes
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100	lag	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	actual	_	_	_	_	_	_	_	_
103	histories	_	_	_	_	_	_	_	_
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105	a	_	_	_	_	_	_	_	_
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107	days	_	_	_	_	_	_	_	_
108	.	_	_	_	_	_	_	_	_
109	Hence	_	_	_	_	_	_	_	BeginSeg=Yes
110	,	_	_	_	_	_	_	_	_
111	to	_	_	_	_	_	_	_	BeginSeg=Yes
112	minimize	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	spread	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	_
117	disease	_	_	_	_	_	_	_	_
118	,	_	_	_	_	_	_	_	_
119	lockdowns	_	_	_	_	_	_	_	BeginSeg=Yes
120	and	_	_	_	_	_	_	_	_
121	similarly	_	_	_	_	_	_	_	_
122	drastic	_	_	_	_	_	_	_	_
123	social	_	_	_	_	_	_	_	_
124	isolation	_	_	_	_	_	_	_	_
125	measures	_	_	_	_	_	_	_	_
126	need	_	_	_	_	_	_	_	_
127	to	_	_	_	_	_	_	_	_
128	be	_	_	_	_	_	_	_	_
129	imposed	_	_	_	_	_	_	_	_
130	some	_	_	_	_	_	_	_	BeginSeg=Yes
131	time	_	_	_	_	_	_	_	_
132	before	_	_	_	_	_	_	_	_
133	the	_	_	_	_	_	_	_	_
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138	their	_	_	_	_	_	_	_	_
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140	values	_	_	_	_	_	_	_	_
141	.	_	_	_	_	_	_	_	_
142	We	_	_	_	_	_	_	_	BeginSeg=Yes
143	then	_	_	_	_	_	_	_	_
144	account	_	_	_	_	_	_	_	_
145	for	_	_	_	_	_	_	_	_
146	the	_	_	_	_	_	_	_	_
147	social	_	_	_	_	_	_	_	_
148	reality	_	_	_	_	_	_	_	_
149	that	_	_	_	_	_	_	_	BeginSeg=Yes
150	lockdowns	_	_	_	_	_	_	_	_
151	can	_	_	_	_	_	_	_	_
152	only	_	_	_	_	_	_	_	_
153	be	_	_	_	_	_	_	_	_
154	of	_	_	_	_	_	_	_	_
155	a	_	_	_	_	_	_	_	_
156	limited	_	_	_	_	_	_	_	_
157	duration	_	_	_	_	_	_	_	_
158	in	_	_	_	_	_	_	_	_
159	view	_	_	_	_	_	_	_	_
160	of	_	_	_	_	_	_	_	_
161	practical	_	_	_	_	_	_	_	_
162	considerations	_	_	_	_	_	_	_	_
163	.	_	_	_	_	_	_	_	_
164	We	_	_	_	_	_	_	_	BeginSeg=Yes
165	find	_	_	_	_	_	_	_	_
166	that	_	_	_	_	_	_	_	BeginSeg=Yes
167	the	_	_	_	_	_	_	_	_
168	most	_	_	_	_	_	_	_	_
169	effective	_	_	_	_	_	_	_	_
170	interval	_	_	_	_	_	_	_	_
171	for	_	_	_	_	_	_	_	BeginSeg=Yes
172	imposing	_	_	_	_	_	_	_	_
173	such	_	_	_	_	_	_	_	_
174	a	_	_	_	_	_	_	_	_
175	limited	_	_	_	_	_	_	_	_
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177	time	_	_	_	_	_	_	_	_
178	lockdown	_	_	_	_	_	_	_	_
179	is	_	_	_	_	_	_	_	BeginSeg=Yes
180	one	_	_	_	_	_	_	_	_
181	where	_	_	_	_	_	_	_	BeginSeg=Yes
182	the	_	_	_	_	_	_	_	_
183	midpoint	_	_	_	_	_	_	_	_
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185	the	_	_	_	_	_	_	_	_
186	lockdown	_	_	_	_	_	_	_	_
187	period	_	_	_	_	_	_	_	_
188	coincides	_	_	_	_	_	_	_	_
189	with	_	_	_	_	_	_	_	_
190	the	_	_	_	_	_	_	_	_
191	actual	_	_	_	_	_	_	_	_
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194	the	_	_	_	_	_	_	_	_
195	spread	_	_	_	_	_	_	_	_
196	of	_	_	_	_	_	_	_	_
197	the	_	_	_	_	_	_	_	_
198	disease	_	_	_	_	_	_	_	_
199	in	_	_	_	_	_	_	_	_
200	the	_	_	_	_	_	_	_	_
201	absence	_	_	_	_	_	_	_	_
202	of	_	_	_	_	_	_	_	_
203	the	_	_	_	_	_	_	_	_
204	lockdown	_	_	_	_	_	_	_	_
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206	We	_	_	_	_	_	_	_	BeginSeg=Yes
207	further	_	_	_	_	_	_	_	_
208	show	_	_	_	_	_	_	_	_
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210	the	_	_	_	_	_	_	_	_
211	true	_	_	_	_	_	_	_	_
212	effectivity	_	_	_	_	_	_	_	_
213	of	_	_	_	_	_	_	_	BeginSeg=Yes
214	imposing	_	_	_	_	_	_	_	_
215	a	_	_	_	_	_	_	_	_
216	lockdown	_	_	_	_	_	_	_	_
217	may	_	_	_	_	_	_	_	BeginSeg=Yes
218	be	_	_	_	_	_	_	_	_
219	misrepresented	_	_	_	_	_	_	_	_
220	and	_	_	_	_	_	_	_	_
221	grossly	_	_	_	_	_	_	_	_
222	underestimated	_	_	_	_	_	_	_	_
223	by	_	_	_	_	_	_	_	_
224	the	_	_	_	_	_	_	_	_
225	reported	_	_	_	_	_	_	_	_
226	case	_	_	_	_	_	_	_	_
227	trajectories	_	_	_	_	_	_	_	_
228	in	_	_	_	_	_	_	_	_
229	the	_	_	_	_	_	_	_	_
230	days	_	_	_	_	_	_	_	_
231	following	_	_	_	_	_	_	_	BeginSeg=Yes
232	the	_	_	_	_	_	_	_	_
233	action	_	_	_	_	_	_	_	_
234	.	_	_	_	_	_	_	_	_

# newdoc_id = 3a8a064e3c2e791777f54f39a797baf90c97b653
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2	COVID-19	_	_	_	_	_	_	_	_
3	epidemic	_	_	_	_	_	_	_	_
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5	resulted	_	_	_	_	_	_	_	_
6	in	_	_	_	_	_	_	_	_
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8	hospitals	_	_	_	_	_	_	_	_
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10	practices	_	_	_	_	_	_	_	_
11	to	_	_	_	_	_	_	_	_
12	cancel	_	_	_	_	_	_	_	_
13	in	_	_	_	_	_	_	_	_
14	-	_	_	_	_	_	_	_	_
15	person	_	_	_	_	_	_	_	_
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17	clinic	_	_	_	_	_	_	_	_
18	visits	_	_	_	_	_	_	_	_
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25	receive	_	_	_	_	_	_	_	_
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27	critical	_	_	_	_	_	_	_	_
28	longitudinal	_	_	_	_	_	_	_	_
29	care	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	Out	_	_	_	_	_	_	_	BeginSeg=Yes
32	of	_	_	_	_	_	_	_	_
33	necessity	_	_	_	_	_	_	_	_
34	,	_	_	_	_	_	_	_	_
35	most	_	_	_	_	_	_	_	_
36	practices	_	_	_	_	_	_	_	_
37	have	_	_	_	_	_	_	_	_
38	been	_	_	_	_	_	_	_	_
39	encouraged	_	_	_	_	_	_	_	_
40	to	_	_	_	_	_	_	_	_
41	use	_	_	_	_	_	_	_	_
42	telemedicine	_	_	_	_	_	_	_	_
43	as	_	_	_	_	_	_	_	_
44	a	_	_	_	_	_	_	_	_
45	method	_	_	_	_	_	_	_	_
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47	maintain	_	_	_	_	_	_	_	_
48	a	_	_	_	_	_	_	_	_
49	continuum	_	_	_	_	_	_	_	_
50	of	_	_	_	_	_	_	_	_
51	care	_	_	_	_	_	_	_	_
52	with	_	_	_	_	_	_	_	_
53	their	_	_	_	_	_	_	_	_
54	patients	_	_	_	_	_	_	_	_
55	.	_	_	_	_	_	_	_	_
56	As	_	_	_	_	_	_	_	BeginSeg=Yes
57	a	_	_	_	_	_	_	_	_
58	result	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	prevalence	_	_	_	_	_	_	_	_
62	of	_	_	_	_	_	_	_	_
63	telemedicine	_	_	_	_	_	_	_	_
64	has	_	_	_	_	_	_	_	_
65	grown	_	_	_	_	_	_	_	_
66	rapidly	_	_	_	_	_	_	_	_
67	during	_	_	_	_	_	_	_	_
68	this	_	_	_	_	_	_	_	_
69	pandemic	_	_	_	_	_	_	_	_
70	,	_	_	_	_	_	_	_	_
71	without	_	_	_	_	_	_	_	BeginSeg=Yes
72	allowing	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	physicians	_	_	_	_	_	_	_	_
75	and	_	_	_	_	_	_	_	_
76	patients	_	_	_	_	_	_	_	_
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78	be	_	_	_	_	_	_	_	_
79	adequately	_	_	_	_	_	_	_	_
80	educated	_	_	_	_	_	_	_	_
81	on	_	_	_	_	_	_	_	_
82	how	_	_	_	_	_	_	_	_
83	best	_	_	_	_	_	_	_	_
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85	utilize	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	services	_	_	_	_	_	_	_	_
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90	is	_	_	_	_	_	_	_	_
91	a	_	_	_	_	_	_	_	_
92	steep	_	_	_	_	_	_	_	_
93	learning	_	_	_	_	_	_	_	_
94	curve	_	_	_	_	_	_	_	_
95	as	_	_	_	_	_	_	_	_
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97	have	_	_	_	_	_	_	_	_
98	learned	_	_	_	_	_	_	_	_
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100	and	_	_	_	_	_	_	_	BeginSeg=Yes
101	our	_	_	_	_	_	_	_	_
102	goal	_	_	_	_	_	_	_	_
103	is	_	_	_	_	_	_	_	_
104	to	_	_	_	_	_	_	_	_
105	provide	_	_	_	_	_	_	_	_
106	guidelines	_	_	_	_	_	_	_	_
107	for	_	_	_	_	_	_	_	_
108	both	_	_	_	_	_	_	_	_
109	patients	_	_	_	_	_	_	_	_
110	and	_	_	_	_	_	_	_	_
111	physicians	_	_	_	_	_	_	_	_
112	,	_	_	_	_	_	_	_	_
113	as	_	_	_	_	_	_	_	_
114	well	_	_	_	_	_	_	_	_
115	as	_	_	_	_	_	_	_	_
116	a	_	_	_	_	_	_	_	_
117	valuable	_	_	_	_	_	_	_	_
118	patient	_	_	_	_	_	_	_	_
119	handout	_	_	_	_	_	_	_	_
120	in	_	_	_	_	_	_	_	_
121	preparation	_	_	_	_	_	_	_	_
122	for	_	_	_	_	_	_	_	_
123	their	_	_	_	_	_	_	_	_
124	visit	_	_	_	_	_	_	_	_
125	.	_	_	_	_	_	_	_	_

# newdoc_id = 3dc5bf516803b9db568e51276d44ce5f1562d098
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2	current	_	_	_	_	_	_	_	_
3	explosive	_	_	_	_	_	_	_	_
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5	of	_	_	_	_	_	_	_	_
6	coronavirus	_	_	_	_	_	_	_	_
7	is	_	_	_	_	_	_	_	_
8	posing	_	_	_	_	_	_	_	_
9	serious	_	_	_	_	_	_	_	_
10	threats	_	_	_	_	_	_	_	_
11	to	_	_	_	_	_	_	_	_
12	public	_	_	_	_	_	_	_	_
13	health	_	_	_	_	_	_	_	_
14	and	_	_	_	_	_	_	_	_
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18	world	_	_	_	_	_	_	_	_
19	.	_	_	_	_	_	_	_	_
20	To	_	_	_	_	_	_	_	BeginSeg=Yes
21	clarify	_	_	_	_	_	_	_	_
22	the	_	_	_	_	_	_	_	_
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24	mechanism	_	_	_	_	_	_	_	_
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26	this	_	_	_	_	_	_	_	_
27	disease	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	economy	_	_	_	_	_	_	_	_
30	,	_	_	_	_	_	_	_	_
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32	new	_	_	_	_	_	_	_	_
33	dynamical	_	_	_	_	_	_	_	_
34	system	_	_	_	_	_	_	_	_
35	is	_	_	_	_	_	_	_	_
36	established	_	_	_	_	_	_	_	_
37	.	_	_	_	_	_	_	_	_
38	It	_	_	_	_	_	_	_	BeginSeg=Yes
39	is	_	_	_	_	_	_	_	_
40	theoretically	_	_	_	_	_	_	_	_
41	proved	_	_	_	_	_	_	_	_
42	that	_	_	_	_	_	_	_	_
43	the	_	_	_	_	_	_	_	_
44	basic	_	_	_	_	_	_	_	_
45	reproduction	_	_	_	_	_	_	_	_
46	number	_	_	_	_	_	_	_	_
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48	a	_	_	_	_	_	_	_	_
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50	combination	_	_	_	_	_	_	_	_
51	of	_	_	_	_	_	_	_	_
52	parameters	_	_	_	_	_	_	_	_
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54	disease	_	_	_	_	_	_	_	_
55	transmission	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	intervention	_	_	_	_	_	_	_	_
58	and	_	_	_	_	_	_	_	_
59	economy	_	_	_	_	_	_	_	_
60	effect	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	which	_	_	_	_	_	_	_	BeginSeg=Yes
63	totally	_	_	_	_	_	_	_	_
64	determines	_	_	_	_	_	_	_	_
65	the	_	_	_	_	_	_	_	_
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72	and	_	_	_	_	_	_	_	_
73	endemic	_	_	_	_	_	_	_	_
74	equilibria	_	_	_	_	_	_	_	_
75	.	_	_	_	_	_	_	_	_
76	Further	_	_	_	_	_	_	_	BeginSeg=Yes
77	results	_	_	_	_	_	_	_	_
78	indicate	_	_	_	_	_	_	_	_
79	the	_	_	_	_	_	_	_	_
80	existence	_	_	_	_	_	_	_	_
81	of	_	_	_	_	_	_	_	_
82	interaction	_	_	_	_	_	_	_	_
83	and	_	_	_	_	_	_	_	_
84	mutual	_	_	_	_	_	_	_	_
85	restraint	_	_	_	_	_	_	_	_
86	among	_	_	_	_	_	_	_	_
87	the	_	_	_	_	_	_	_	_
88	transmission	_	_	_	_	_	_	_	_
89	,	_	_	_	_	_	_	_	_
90	intervention	_	_	_	_	_	_	_	_
91	and	_	_	_	_	_	_	_	_
92	economy	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	in	_	_	_	_	_	_	_	BeginSeg=Yes
95	which	_	_	_	_	_	_	_	_
96	strong	_	_	_	_	_	_	_	_
97	coupling	_	_	_	_	_	_	_	_
98	of	_	_	_	_	_	_	_	_
99	COVID-19	_	_	_	_	_	_	_	_
100	and	_	_	_	_	_	_	_	_
101	economy	_	_	_	_	_	_	_	_
102	would	_	_	_	_	_	_	_	_
103	trigger	_	_	_	_	_	_	_	_
104	disease	_	_	_	_	_	_	_	_
105	outbreak	_	_	_	_	_	_	_	_
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107	form	_	_	_	_	_	_	_	_
108	poverty	_	_	_	_	_	_	_	_
109	trap	_	_	_	_	_	_	_	_
110	,	_	_	_	_	_	_	_	_
111	while	_	_	_	_	_	_	_	BeginSeg=Yes
112	adaptive	_	_	_	_	_	_	_	_
113	isolation	_	_	_	_	_	_	_	_
114	of	_	_	_	_	_	_	_	_
115	at	_	_	_	_	_	_	_	_
116	-	_	_	_	_	_	_	_	_
117	risk	_	_	_	_	_	_	_	_
118	population	_	_	_	_	_	_	_	_
119	could	_	_	_	_	_	_	_	_
120	effectively	_	_	_	_	_	_	_	_
121	reduce	_	_	_	_	_	_	_	_
122	morbidity	_	_	_	_	_	_	_	_
123	at	_	_	_	_	_	_	_	_
124	the	_	_	_	_	_	_	_	_
125	cost	_	_	_	_	_	_	_	_
126	of	_	_	_	_	_	_	_	_
127	least	_	_	_	_	_	_	_	_
128	economic	_	_	_	_	_	_	_	_
129	loss	_	_	_	_	_	_	_	_
130	.	_	_	_	_	_	_	_	_
131	Our	_	_	_	_	_	_	_	BeginSeg=Yes
132	findings	_	_	_	_	_	_	_	_
133	can	_	_	_	_	_	_	_	_
134	offer	_	_	_	_	_	_	_	_
135	new	_	_	_	_	_	_	_	_
136	insights	_	_	_	_	_	_	_	_
137	to	_	_	_	_	_	_	_	BeginSeg=Yes
138	improve	_	_	_	_	_	_	_	_
139	the	_	_	_	_	_	_	_	_
140	intervention	_	_	_	_	_	_	_	_
141	strategies	_	_	_	_	_	_	_	_
142	against	_	_	_	_	_	_	_	_
143	COVID-19	_	_	_	_	_	_	_	_
144	.	_	_	_	_	_	_	_	_

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2	article	_	_	_	_	_	_	_	_
3	examines	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	political	_	_	_	_	_	_	_	_
6	and	_	_	_	_	_	_	_	_
7	criminological	_	_	_	_	_	_	_	_
8	history	_	_	_	_	_	_	_	_
9	of	_	_	_	_	_	_	_	_
10	anti	_	_	_	_	_	_	_	_
11	-	_	_	_	_	_	_	_	_
12	money	_	_	_	_	_	_	_	_
13	controls	_	_	_	_	_	_	_	_
14	,	_	_	_	_	_	_	_	_
15	including	_	_	_	_	_	_	_	BeginSeg=Yes
16	the	_	_	_	_	_	_	_	_
17	involvement	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	Asian	_	_	_	_	_	_	_	_
20	countries	_	_	_	_	_	_	_	_
21	and	_	_	_	_	_	_	_	_
22	the	_	_	_	_	_	_	_	_
23	varied	_	_	_	_	_	_	_	_
24	motivations	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	interests	_	_	_	_	_	_	_	_
27	engaged	_	_	_	_	_	_	_	_
28	.	_	_	_	_	_	_	_	_
29	It	_	_	_	_	_	_	_	BeginSeg=Yes
30	goes	_	_	_	_	_	_	_	_
31	on	_	_	_	_	_	_	_	_
32	to	_	_	_	_	_	_	_	_
33	review	_	_	_	_	_	_	_	_
34	where	_	_	_	_	_	_	_	_
35	empirical	_	_	_	_	_	_	_	_
36	evidence	_	_	_	_	_	_	_	_
37	has	_	_	_	_	_	_	_	_
38	been	_	_	_	_	_	_	_	_
39	used	_	_	_	_	_	_	_	_
40	and	_	_	_	_	_	_	_	_
41	can	_	_	_	_	_	_	_	_
42	be	_	_	_	_	_	_	_	_
43	used	_	_	_	_	_	_	_	_
44	in	_	_	_	_	_	_	_	BeginSeg=Yes
45	fighting	_	_	_	_	_	_	_	_
46	the	_	_	_	_	_	_	_	_
47	financial	_	_	_	_	_	_	_	_
48	components	_	_	_	_	_	_	_	_
49	of	_	_	_	_	_	_	_	BeginSeg=Yes
50	underlying	_	_	_	_	_	_	_	_
51	crimes	_	_	_	_	_	_	_	_
52	,	_	_	_	_	_	_	_	_
53	examining	_	_	_	_	_	_	_	BeginSeg=Yes
54	the	_	_	_	_	_	_	_	_
55	denotation	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	the	_	_	_	_	_	_	_	_
58	problem(s	_	_	_	_	_	_	_	_
59	)	_	_	_	_	_	_	_	_
60	we	_	_	_	_	_	_	_	BeginSeg=Yes
61	are	_	_	_	_	_	_	_	_
62	supposed	_	_	_	_	_	_	_	_
63	to	_	_	_	_	_	_	_	_
64	be	_	_	_	_	_	_	_	_
65	fighting	_	_	_	_	_	_	_	_
66	-	_	_	_	_	_	_	_	BeginSeg=Yes
67	money	_	_	_	_	_	_	_	_
68	laundering	_	_	_	_	_	_	_	_
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70	an	_	_	_	_	_	_	_	_
71	evil	_	_	_	_	_	_	_	_
72	in	_	_	_	_	_	_	_	_
73	itself	_	_	_	_	_	_	_	_
74	and/or	_	_	_	_	_	_	_	_
75	the	_	_	_	_	_	_	_	_
76	underlying	_	_	_	_	_	_	_	_
77	crimes	_	_	_	_	_	_	_	_
78	which	_	_	_	_	_	_	_	BeginSeg=Yes
79	give	_	_	_	_	_	_	_	_
80	rise	_	_	_	_	_	_	_	_
81	to	_	_	_	_	_	_	_	_
82	it	_	_	_	_	_	_	_	_
83	;	_	_	_	_	_	_	_	_
84	estimates	_	_	_	_	_	_	_	BeginSeg=Yes
85	of	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	size	_	_	_	_	_	_	_	_
88	and	_	_	_	_	_	_	_	_
89	harmfulness	_	_	_	_	_	_	_	_
90	of	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
92	problems	_	_	_	_	_	_	_	_
93	and	_	_	_	_	_	_	_	BeginSeg=Yes
94	identifies	_	_	_	_	_	_	_	_
95	any	_	_	_	_	_	_	_	_
96	improvements	_	_	_	_	_	_	_	_
97	/	_	_	_	_	_	_	_	_
98	emerging	_	_	_	_	_	_	_	_
99	problems	_	_	_	_	_	_	_	_
100	in	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	assessment	_	_	_	_	_	_	_	_
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105	laundering	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	It	_	_	_	_	_	_	_	BeginSeg=Yes
108	concludes	_	_	_	_	_	_	_	_
109	with	_	_	_	_	_	_	_	_
110	some	_	_	_	_	_	_	_	_
111	reflections	_	_	_	_	_	_	_	_
112	on	_	_	_	_	_	_	_	_
113	assessing	_	_	_	_	_	_	_	_
114	policy	_	_	_	_	_	_	_	_
115	effectiveness	_	_	_	_	_	_	_	_
116	and	_	_	_	_	_	_	_	_
117	the	_	_	_	_	_	_	_	_
118	need	_	_	_	_	_	_	_	_
119	for	_	_	_	_	_	_	_	_
120	greater	_	_	_	_	_	_	_	_
121	engagement	_	_	_	_	_	_	_	_
122	by	_	_	_	_	_	_	_	_
123	criminologists	_	_	_	_	_	_	_	_
124	and	_	_	_	_	_	_	_	_
125	other	_	_	_	_	_	_	_	_
126	social	_	_	_	_	_	_	_	_
127	scientists	_	_	_	_	_	_	_	_
128	in	_	_	_	_	_	_	_	_
129	this	_	_	_	_	_	_	_	_
130	process	_	_	_	_	_	_	_	_
131	.	_	_	_	_	_	_	_	_

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10	presently	_	_	_	_	_	_	_	_
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106	were	_	_	_	_	_	_	_	_
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108	biologically	_	_	_	_	_	_	_	_
109	relevant	_	_	_	_	_	_	_	_
110	.	_	_	_	_	_	_	_	_
111	All	_	_	_	_	_	_	_	BeginSeg=Yes
112	animals	_	_	_	_	_	_	_	_
113	survived	_	_	_	_	_	_	_	_
114	and	_	_	_	_	_	_	_	BeginSeg=Yes
115	no	_	_	_	_	_	_	_	_
116	adverse	_	_	_	_	_	_	_	_
117	clinical	_	_	_	_	_	_	_	_
118	signs	_	_	_	_	_	_	_	_
119	or	_	_	_	_	_	_	_	_
120	functional	_	_	_	_	_	_	_	_
121	changes	_	_	_	_	_	_	_	_
122	were	_	_	_	_	_	_	_	_
123	attributable	_	_	_	_	_	_	_	_
124	to	_	_	_	_	_	_	_	_
125	the	_	_	_	_	_	_	_	_
126	test	_	_	_	_	_	_	_	_
127	material	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	There	_	_	_	_	_	_	_	BeginSeg=Yes
130	were	_	_	_	_	_	_	_	_
131	no	_	_	_	_	_	_	_	_
132	toxicologically	_	_	_	_	_	_	_	_
133	relevant	_	_	_	_	_	_	_	_
134	changes	_	_	_	_	_	_	_	_
135	in	_	_	_	_	_	_	_	_
136	hematology	_	_	_	_	_	_	_	_
137	,	_	_	_	_	_	_	_	_
138	clinical	_	_	_	_	_	_	_	_
139	chemistry	_	_	_	_	_	_	_	_
140	or	_	_	_	_	_	_	_	_
141	urinalysis	_	_	_	_	_	_	_	_
142	parameters	_	_	_	_	_	_	_	_
143	or	_	_	_	_	_	_	_	_
144	organ	_	_	_	_	_	_	_	_
145	weights	_	_	_	_	_	_	_	_
146	in	_	_	_	_	_	_	_	_
147	rats	_	_	_	_	_	_	_	_
148	ingesting	_	_	_	_	_	_	_	BeginSeg=Yes
149	pecan	_	_	_	_	_	_	_	_
150	shell	_	_	_	_	_	_	_	_
151	fiber	_	_	_	_	_	_	_	_
152	.	_	_	_	_	_	_	_	_
153	Any	_	_	_	_	_	_	_	BeginSeg=Yes
154	macroscopic	_	_	_	_	_	_	_	_
155	or	_	_	_	_	_	_	_	_
156	microscopic	_	_	_	_	_	_	_	_
157	findings	_	_	_	_	_	_	_	_
158	were	_	_	_	_	_	_	_	_
159	incidental	_	_	_	_	_	_	_	_
160	,	_	_	_	_	_	_	_	_
161	of	_	_	_	_	_	_	_	_
162	normal	_	_	_	_	_	_	_	_
163	variation	_	_	_	_	_	_	_	_
164	and/or	_	_	_	_	_	_	_	_
165	of	_	_	_	_	_	_	_	_
166	minimal	_	_	_	_	_	_	_	_
167	magnitude	_	_	_	_	_	_	_	_
168	for	_	_	_	_	_	_	_	_
169	test	_	_	_	_	_	_	_	_
170	substance	_	_	_	_	_	_	_	_
171	association	_	_	_	_	_	_	_	_
172	.	_	_	_	_	_	_	_	_
173	Pecan	_	_	_	_	_	_	_	BeginSeg=Yes
174	shell	_	_	_	_	_	_	_	_
175	fiber	_	_	_	_	_	_	_	_
176	was	_	_	_	_	_	_	_	_
177	non	_	_	_	_	_	_	_	_
178	-	_	_	_	_	_	_	_	_
179	mutagenic	_	_	_	_	_	_	_	_
180	in	_	_	_	_	_	_	_	_
181	a	_	_	_	_	_	_	_	_
182	bacterial	_	_	_	_	_	_	_	_
183	reverse	_	_	_	_	_	_	_	_
184	mutation	_	_	_	_	_	_	_	_
185	test	_	_	_	_	_	_	_	_
186	and	_	_	_	_	_	_	_	_
187	non	_	_	_	_	_	_	_	_
188	-	_	_	_	_	_	_	_	_
189	clastogenic	_	_	_	_	_	_	_	_
190	in	_	_	_	_	_	_	_	_
191	a	_	_	_	_	_	_	_	_
192	mouse	_	_	_	_	_	_	_	_
193	peripheral	_	_	_	_	_	_	_	_
194	blood	_	_	_	_	_	_	_	_
195	micronucleus	_	_	_	_	_	_	_	_
196	test	_	_	_	_	_	_	_	_
197	.	_	_	_	_	_	_	_	_
198	Based	_	_	_	_	_	_	_	BeginSeg=Yes
199	on	_	_	_	_	_	_	_	_
200	these	_	_	_	_	_	_	_	_
201	results	_	_	_	_	_	_	_	_
202	,	_	_	_	_	_	_	_	_
203	pecan	_	_	_	_	_	_	_	BeginSeg=Yes
204	shell	_	_	_	_	_	_	_	_
205	fiber	_	_	_	_	_	_	_	_
206	has	_	_	_	_	_	_	_	_
207	an	_	_	_	_	_	_	_	_
208	oral	_	_	_	_	_	_	_	_
209	subchronic	_	_	_	_	_	_	_	_
210	(	_	_	_	_	_	_	_	BeginSeg=Yes
211	13-week	_	_	_	_	_	_	_	_
212	)	_	_	_	_	_	_	_	_
213	no	_	_	_	_	_	_	_	BeginSeg=Yes
214	observable	_	_	_	_	_	_	_	_
215	adverse	_	_	_	_	_	_	_	_
216	effect	_	_	_	_	_	_	_	_
217	level	_	_	_	_	_	_	_	_
218	(	_	_	_	_	_	_	_	_
219	NOAEL	_	_	_	_	_	_	_	_
220	)	_	_	_	_	_	_	_	_
221	of	_	_	_	_	_	_	_	_
222	150	_	_	_	_	_	_	_	_
223	000	_	_	_	_	_	_	_	_
224	ppm	_	_	_	_	_	_	_	_
225	in	_	_	_	_	_	_	_	_
226	rats	_	_	_	_	_	_	_	_
227	and	_	_	_	_	_	_	_	BeginSeg=Yes
228	is	_	_	_	_	_	_	_	_
229	not	_	_	_	_	_	_	_	_
230	genotoxic	_	_	_	_	_	_	_	_
231	at	_	_	_	_	_	_	_	_
232	the	_	_	_	_	_	_	_	_
233	doses	_	_	_	_	_	_	_	_
234	analyzed	_	_	_	_	_	_	_	_
235	.	_	_	_	_	_	_	_	_

# newdoc_id = 3fe0d4ab3e3152159123b351f7adc98186d01449
1	Coronavirus	_	_	_	_	_	_	_	BeginSeg=Yes
2	disease	_	_	_	_	_	_	_	_
3	2019	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	i.e.	_	_	_	_	_	_	_	_
6	COVID-19	_	_	_	_	_	_	_	_
7	has	_	_	_	_	_	_	_	_
8	imposed	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	public	_	_	_	_	_	_	_	_
11	health	_	_	_	_	_	_	_	_
12	measure	_	_	_	_	_	_	_	_
13	of	_	_	_	_	_	_	_	BeginSeg=Yes
14	keeping	_	_	_	_	_	_	_	_
15	social	_	_	_	_	_	_	_	_
16	distancing	_	_	_	_	_	_	_	_
17	for	_	_	_	_	_	_	_	BeginSeg=Yes
18	preventing	_	_	_	_	_	_	_	_
19	mass	_	_	_	_	_	_	_	_
20	transmission	_	_	_	_	_	_	_	_
21	of	_	_	_	_	_	_	_	_
22	COVID-19	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
24	For	_	_	_	_	_	_	_	BeginSeg=Yes
25	monitoring	_	_	_	_	_	_	_	_
26	the	_	_	_	_	_	_	_	_
27	social	_	_	_	_	_	_	_	_
28	distancing	_	_	_	_	_	_	_	_
29	and	_	_	_	_	_	_	_	BeginSeg=Yes
30	keeping	_	_	_	_	_	_	_	_
31	the	_	_	_	_	_	_	_	_
32	trace	_	_	_	_	_	_	_	_
33	of	_	_	_	_	_	_	_	_
34	transmission	_	_	_	_	_	_	_	_
35	,	_	_	_	_	_	_	_	_
36	we	_	_	_	_	_	_	_	BeginSeg=Yes
37	are	_	_	_	_	_	_	_	_
38	obligated	_	_	_	_	_	_	_	_
39	to	_	_	_	_	_	_	_	_
40	develop	_	_	_	_	_	_	_	_
41	various	_	_	_	_	_	_	_	_
42	types	_	_	_	_	_	_	_	_
43	of	_	_	_	_	_	_	_	_
44	digital	_	_	_	_	_	_	_	_
45	surveillance	_	_	_	_	_	_	_	_
46	systems	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	which	_	_	_	_	_	_	_	BeginSeg=Yes
49	include	_	_	_	_	_	_	_	_
50	contact	_	_	_	_	_	_	_	_
51	tracing	_	_	_	_	_	_	_	_
52	systems	_	_	_	_	_	_	_	_
53	and	_	_	_	_	_	_	_	_
54	drone	_	_	_	_	_	_	_	_
55	-	_	_	_	_	_	_	_	_
56	based	_	_	_	_	_	_	_	_
57	monitoring	_	_	_	_	_	_	_	_
58	systems	_	_	_	_	_	_	_	_
59	.	_	_	_	_	_	_	_	_
60	Due	_	_	_	_	_	_	_	BeginSeg=Yes
61	to	_	_	_	_	_	_	_	_
62	the	_	_	_	_	_	_	_	_
63	inconvenience	_	_	_	_	_	_	_	_
64	of	_	_	_	_	_	_	_	_
65	manual	_	_	_	_	_	_	_	_
66	labor	_	_	_	_	_	_	_	_
67	,	_	_	_	_	_	_	_	_
68	traditional	_	_	_	_	_	_	_	BeginSeg=Yes
69	contact	_	_	_	_	_	_	_	_
70	tracing	_	_	_	_	_	_	_	_
71	systems	_	_	_	_	_	_	_	_
72	are	_	_	_	_	_	_	_	_
73	gradually	_	_	_	_	_	_	_	_
74	replaced	_	_	_	_	_	_	_	_
75	by	_	_	_	_	_	_	_	_
76	the	_	_	_	_	_	_	_	_
77	efficient	_	_	_	_	_	_	_	_
78	automated	_	_	_	_	_	_	_	_
79	contact	_	_	_	_	_	_	_	_
80	tracing	_	_	_	_	_	_	_	_
81	applications	_	_	_	_	_	_	_	_
82	that	_	_	_	_	_	_	_	BeginSeg=Yes
83	are	_	_	_	_	_	_	_	_
84	developed	_	_	_	_	_	_	_	_
85	for	_	_	_	_	_	_	_	_
86	smartphones	_	_	_	_	_	_	_	_
87	.	_	_	_	_	_	_	_	_
88	However	_	_	_	_	_	_	_	BeginSeg=Yes
89	,	_	_	_	_	_	_	_	_
90	the	_	_	_	_	_	_	_	_
91	commencement	_	_	_	_	_	_	_	_
92	of	_	_	_	_	_	_	_	_
93	automated	_	_	_	_	_	_	_	_
94	contact	_	_	_	_	_	_	_	_
95	tracing	_	_	_	_	_	_	_	_
96	applications	_	_	_	_	_	_	_	_
97	introduces	_	_	_	_	_	_	_	_
98	the	_	_	_	_	_	_	_	_
99	inevitable	_	_	_	_	_	_	_	_
100	privacy	_	_	_	_	_	_	_	_
101	and	_	_	_	_	_	_	_	_
102	security	_	_	_	_	_	_	_	_
103	challenges	_	_	_	_	_	_	_	_
104	.	_	_	_	_	_	_	_	_
105	Nevertheless	_	_	_	_	_	_	_	BeginSeg=Yes
106	,	_	_	_	_	_	_	_	_
107	unawareness	_	_	_	_	_	_	_	_
108	and/or	_	_	_	_	_	_	_	_
109	lack	_	_	_	_	_	_	_	_
110	of	_	_	_	_	_	_	_	_
111	smartphone	_	_	_	_	_	_	_	_
112	usage	_	_	_	_	_	_	_	_
113	among	_	_	_	_	_	_	_	_
114	mass	_	_	_	_	_	_	_	_
115	people	_	_	_	_	_	_	_	_
116	lead	_	_	_	_	_	_	_	_
117	to	_	_	_	_	_	_	_	_
118	drone	_	_	_	_	_	_	_	_
119	-	_	_	_	_	_	_	_	_
120	based	_	_	_	_	_	_	_	_
121	monitoring	_	_	_	_	_	_	_	_
122	systems	_	_	_	_	_	_	_	_
123	.	_	_	_	_	_	_	_	_
124	These	_	_	_	_	_	_	_	BeginSeg=Yes
125	systems	_	_	_	_	_	_	_	_
126	also	_	_	_	_	_	_	_	_
127	invite	_	_	_	_	_	_	_	_
128	unwelcomed	_	_	_	_	_	_	_	_
129	privacy	_	_	_	_	_	_	_	_
130	and	_	_	_	_	_	_	_	_
131	security	_	_	_	_	_	_	_	_
132	challenges	_	_	_	_	_	_	_	_
133	.	_	_	_	_	_	_	_	_
134	This	_	_	_	_	_	_	_	BeginSeg=Yes
135	paper	_	_	_	_	_	_	_	_
136	discusses	_	_	_	_	_	_	_	_
137	the	_	_	_	_	_	_	_	_
138	recently	_	_	_	_	_	_	_	_
139	designed	_	_	_	_	_	_	_	_
140	and	_	_	_	_	_	_	_	_
141	developed	_	_	_	_	_	_	_	_
142	digital	_	_	_	_	_	_	_	_
143	surveillance	_	_	_	_	_	_	_	_
144	system	_	_	_	_	_	_	_	_
145	applications	_	_	_	_	_	_	_	_
146	with	_	_	_	_	_	_	_	_
147	their	_	_	_	_	_	_	_	_
148	protocols	_	_	_	_	_	_	_	_
149	deployed	_	_	_	_	_	_	_	BeginSeg=Yes
150	in	_	_	_	_	_	_	_	_
151	several	_	_	_	_	_	_	_	_
152	countries	_	_	_	_	_	_	_	_
153	around	_	_	_	_	_	_	_	_
154	the	_	_	_	_	_	_	_	_
155	world	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_
157	Their	_	_	_	_	_	_	_	BeginSeg=Yes
158	privacy	_	_	_	_	_	_	_	_
159	and	_	_	_	_	_	_	_	_
160	security	_	_	_	_	_	_	_	_
161	challenges	_	_	_	_	_	_	_	_
162	are	_	_	_	_	_	_	_	_
163	discussed	_	_	_	_	_	_	_	_
164	as	_	_	_	_	_	_	_	_
165	well	_	_	_	_	_	_	_	_
166	as	_	_	_	_	_	_	_	_
167	analyzed	_	_	_	_	_	_	_	_
168	from	_	_	_	_	_	_	_	_
169	the	_	_	_	_	_	_	_	_
170	viewpoint	_	_	_	_	_	_	_	_
171	of	_	_	_	_	_	_	_	_
172	privacy	_	_	_	_	_	_	_	_
173	acts	_	_	_	_	_	_	_	_
174	.	_	_	_	_	_	_	_	_
175	Several	_	_	_	_	_	_	_	BeginSeg=Yes
176	recommendations	_	_	_	_	_	_	_	_
177	are	_	_	_	_	_	_	_	_
178	suggested	_	_	_	_	_	_	_	_
179	separately	_	_	_	_	_	_	_	_
180	for	_	_	_	_	_	_	_	_
181	automated	_	_	_	_	_	_	_	_
182	contact	_	_	_	_	_	_	_	_
183	tracing	_	_	_	_	_	_	_	_
184	systems	_	_	_	_	_	_	_	_
185	and	_	_	_	_	_	_	_	_
186	drone	_	_	_	_	_	_	_	_
187	-	_	_	_	_	_	_	_	_
188	based	_	_	_	_	_	_	_	_
189	monitoring	_	_	_	_	_	_	_	_
190	systems	_	_	_	_	_	_	_	_
191	,	_	_	_	_	_	_	_	_
192	which	_	_	_	_	_	_	_	BeginSeg=Yes
193	could	_	_	_	_	_	_	_	_
194	further	_	_	_	_	_	_	_	_
195	be	_	_	_	_	_	_	_	_
196	explored	_	_	_	_	_	_	_	_
197	and	_	_	_	_	_	_	_	_
198	implemented	_	_	_	_	_	_	_	_
199	afterwards	_	_	_	_	_	_	_	_
200	to	_	_	_	_	_	_	_	BeginSeg=Yes
201	prevent	_	_	_	_	_	_	_	_
202	any	_	_	_	_	_	_	_	_
203	possible	_	_	_	_	_	_	_	_
204	privacy	_	_	_	_	_	_	_	_
205	violation	_	_	_	_	_	_	_	_
206	and	_	_	_	_	_	_	_	BeginSeg=Yes
207	protect	_	_	_	_	_	_	_	_
208	an	_	_	_	_	_	_	_	_
209	unsuspecting	_	_	_	_	_	_	_	_
210	person	_	_	_	_	_	_	_	_
211	from	_	_	_	_	_	_	_	_
212	any	_	_	_	_	_	_	_	_
213	potential	_	_	_	_	_	_	_	_
214	cyber	_	_	_	_	_	_	_	_
215	attack	_	_	_	_	_	_	_	_
216	.	_	_	_	_	_	_	_	_

# newdoc_id = 4033e2eca1d60dd76eb5d894dad074202cb21d96
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	standard	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	reference	_	_	_	_	_	_	_	_
5	for	_	_	_	_	_	_	_	BeginSeg=Yes
6	confirming	_	_	_	_	_	_	_	_
7	COVID-19	_	_	_	_	_	_	_	_
8	relies	_	_	_	_	_	_	_	BeginSeg=Yes
9	on	_	_	_	_	_	_	_	_
10	microbiological	_	_	_	_	_	_	_	_
11	tests	_	_	_	_	_	_	_	_
12	such	_	_	_	_	_	_	_	BeginSeg=Yes
13	as	_	_	_	_	_	_	_	_
14	real	_	_	_	_	_	_	_	_
15	-	_	_	_	_	_	_	_	_
16	time	_	_	_	_	_	_	_	_
17	polymerase	_	_	_	_	_	_	_	_
18	chain	_	_	_	_	_	_	_	_
19	reaction	_	_	_	_	_	_	_	_
20	(	_	_	_	_	_	_	_	_
21	RT	_	_	_	_	_	_	_	_
22	-	_	_	_	_	_	_	_	_
23	PCR	_	_	_	_	_	_	_	_
24	)	_	_	_	_	_	_	_	_
25	or	_	_	_	_	_	_	_	_
26	sequencing	_	_	_	_	_	_	_	_
27	.	_	_	_	_	_	_	_	_
28	However	_	_	_	_	_	_	_	BeginSeg=Yes
29	,	_	_	_	_	_	_	_	_
30	these	_	_	_	_	_	_	_	_
31	tests	_	_	_	_	_	_	_	_
32	might	_	_	_	_	_	_	_	_
33	not	_	_	_	_	_	_	_	_
34	be	_	_	_	_	_	_	_	_
35	available	_	_	_	_	_	_	_	_
36	in	_	_	_	_	_	_	_	_
37	an	_	_	_	_	_	_	_	_
38	emergency	_	_	_	_	_	_	_	_
39	setting	_	_	_	_	_	_	_	_
40	.	_	_	_	_	_	_	_	_
41	Computed	_	_	_	_	_	_	_	BeginSeg=Yes
42	tomography	_	_	_	_	_	_	_	_
43	(	_	_	_	_	_	_	_	_
44	CT	_	_	_	_	_	_	_	_
45	)	_	_	_	_	_	_	_	_
46	can	_	_	_	_	_	_	_	_
47	be	_	_	_	_	_	_	_	_
48	used	_	_	_	_	_	_	_	_
49	as	_	_	_	_	_	_	_	_
50	an	_	_	_	_	_	_	_	_
51	important	_	_	_	_	_	_	_	_
52	complement	_	_	_	_	_	_	_	_
53	for	_	_	_	_	_	_	_	_
54	the	_	_	_	_	_	_	_	_
55	diagnosis	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	COVID-19	_	_	_	_	_	_	_	_
58	pneumonia	_	_	_	_	_	_	_	_
59	in	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	current	_	_	_	_	_	_	_	_
62	epidemic	_	_	_	_	_	_	_	_
63	context	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
65	In	_	_	_	_	_	_	_	BeginSeg=Yes
66	this	_	_	_	_	_	_	_	_
67	review	_	_	_	_	_	_	_	_
68	,	_	_	_	_	_	_	_	_
69	we	_	_	_	_	_	_	_	_
70	present	_	_	_	_	_	_	_	_
71	the	_	_	_	_	_	_	_	_
72	typical	_	_	_	_	_	_	_	_
73	CT	_	_	_	_	_	_	_	_
74	features	_	_	_	_	_	_	_	_
75	of	_	_	_	_	_	_	_	_
76	COVID-19	_	_	_	_	_	_	_	_
77	pneumonia	_	_	_	_	_	_	_	_
78	and	_	_	_	_	_	_	_	BeginSeg=Yes
79	discuss	_	_	_	_	_	_	_	_
80	the	_	_	_	_	_	_	_	_
81	main	_	_	_	_	_	_	_	_
82	differential	_	_	_	_	_	_	_	_
83	diagnosis	_	_	_	_	_	_	_	_
84	.	_	_	_	_	_	_	_	_

# newdoc_id = 4043a852290c8823faa76b7592c9f9927c7d0928
1	Patients	_	_	_	_	_	_	_	BeginSeg=Yes
2	with	_	_	_	_	_	_	_	_
3	severe	_	_	_	_	_	_	_	_
4	acute	_	_	_	_	_	_	_	_
5	respiratory	_	_	_	_	_	_	_	_
6	syndrome	_	_	_	_	_	_	_	_
7	(	_	_	_	_	_	_	_	_
8	SARS	_	_	_	_	_	_	_	_
9	)	_	_	_	_	_	_	_	_
10	may	_	_	_	_	_	_	_	_
11	present	_	_	_	_	_	_	_	_
12	with	_	_	_	_	_	_	_	_
13	extra	_	_	_	_	_	_	_	_
14	-	_	_	_	_	_	_	_	_
15	pulmonary	_	_	_	_	_	_	_	_
16	symptoms	_	_	_	_	_	_	_	_
17	.	_	_	_	_	_	_	_	_
18	We	_	_	_	_	_	_	_	BeginSeg=Yes
19	report	_	_	_	_	_	_	_	_
20	a	_	_	_	_	_	_	_	_
21	16-year	_	_	_	_	_	_	_	_
22	-	_	_	_	_	_	_	_	_
23	old	_	_	_	_	_	_	_	_
24	adolescent	_	_	_	_	_	_	_	_
25	with	_	_	_	_	_	_	_	_
26	SARS	_	_	_	_	_	_	_	_
27	who	_	_	_	_	_	_	_	BeginSeg=Yes
28	presented	_	_	_	_	_	_	_	_
29	with	_	_	_	_	_	_	_	_
30	diarrhoea	_	_	_	_	_	_	_	_
31	.	_	_	_	_	_	_	_	_
32	Treatment	_	_	_	_	_	_	_	BeginSeg=Yes
33	directed	_	_	_	_	_	_	_	BeginSeg=Yes
34	against	_	_	_	_	_	_	_	_
35	SARS	_	_	_	_	_	_	_	_
36	was	_	_	_	_	_	_	_	BeginSeg=Yes
37	prompted	_	_	_	_	_	_	_	_
38	by	_	_	_	_	_	_	_	_
39	an	_	_	_	_	_	_	_	_
40	epidemiological	_	_	_	_	_	_	_	_
41	link	_	_	_	_	_	_	_	_
42	and	_	_	_	_	_	_	_	_
43	the	_	_	_	_	_	_	_	_
44	clinical	_	_	_	_	_	_	_	_
45	picture	_	_	_	_	_	_	_	_
46	as	_	_	_	_	_	_	_	BeginSeg=Yes
47	the	_	_	_	_	_	_	_	_
48	disease	_	_	_	_	_	_	_	_
49	evolved	_	_	_	_	_	_	_	_
50	.	_	_	_	_	_	_	_	_
51	This	_	_	_	_	_	_	_	BeginSeg=Yes
52	atypical	_	_	_	_	_	_	_	_
53	presentation	_	_	_	_	_	_	_	_
54	posed	_	_	_	_	_	_	_	_
55	a	_	_	_	_	_	_	_	_
56	diagnostic	_	_	_	_	_	_	_	_
57	challenge	_	_	_	_	_	_	_	_
58	for	_	_	_	_	_	_	_	_
59	physicians	_	_	_	_	_	_	_	_
60	.	_	_	_	_	_	_	_	_
61	Conclusion	_	_	_	_	_	_	_	BeginSeg=Yes
62	:	_	_	_	_	_	_	_	_
63	Proper	_	_	_	_	_	_	_	BeginSeg=Yes
64	disposal	_	_	_	_	_	_	_	_
65	of	_	_	_	_	_	_	_	_
66	patient	_	_	_	_	_	_	_	_
67	excreta	_	_	_	_	_	_	_	_
68	is	_	_	_	_	_	_	_	_
69	important	_	_	_	_	_	_	_	_
70	to	_	_	_	_	_	_	_	BeginSeg=Yes
71	prevent	_	_	_	_	_	_	_	_
72	the	_	_	_	_	_	_	_	_
73	spread	_	_	_	_	_	_	_	_
74	of	_	_	_	_	_	_	_	_
75	severe	_	_	_	_	_	_	_	_
76	acute	_	_	_	_	_	_	_	_
77	respiratory	_	_	_	_	_	_	_	_
78	syndrome	_	_	_	_	_	_	_	_
79	.	_	_	_	_	_	_	_	_

# newdoc_id = 41a35d16de1630c28ba07b3ab3b7ab78ccef25ac
1	Mesenchymal	_	_	_	_	_	_	_	BeginSeg=Yes
2	stem	_	_	_	_	_	_	_	_
3	cells	_	_	_	_	_	_	_	_
4	(	_	_	_	_	_	_	_	_
5	MSCs	_	_	_	_	_	_	_	_
6	)	_	_	_	_	_	_	_	_
7	have	_	_	_	_	_	_	_	_
8	been	_	_	_	_	_	_	_	_
9	extensively	_	_	_	_	_	_	_	_
10	investigated	_	_	_	_	_	_	_	_
11	for	_	_	_	_	_	_	_	_
12	the	_	_	_	_	_	_	_	_
13	treatment	_	_	_	_	_	_	_	_
14	of	_	_	_	_	_	_	_	_
15	various	_	_	_	_	_	_	_	_
16	diseases	_	_	_	_	_	_	_	_
17	.	_	_	_	_	_	_	_	_
18	The	_	_	_	_	_	_	_	BeginSeg=Yes
19	therapeutic	_	_	_	_	_	_	_	_
20	potential	_	_	_	_	_	_	_	_
21	of	_	_	_	_	_	_	_	_
22	MSCs	_	_	_	_	_	_	_	_
23	is	_	_	_	_	_	_	_	_
24	attributed	_	_	_	_	_	_	_	_
25	to	_	_	_	_	_	_	_	_
26	complex	_	_	_	_	_	_	_	_
27	cellular	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	molecular	_	_	_	_	_	_	_	_
30	mechanisms	_	_	_	_	_	_	_	_
31	of	_	_	_	_	_	_	_	_
32	action	_	_	_	_	_	_	_	_
33	including	_	_	_	_	_	_	_	BeginSeg=Yes
34	differentiation	_	_	_	_	_	_	_	_
35	into	_	_	_	_	_	_	_	_
36	multiple	_	_	_	_	_	_	_	_
37	cell	_	_	_	_	_	_	_	_
38	lineages	_	_	_	_	_	_	_	_
39	and	_	_	_	_	_	_	_	_
40	regulation	_	_	_	_	_	_	_	_
41	of	_	_	_	_	_	_	_	_
42	immune	_	_	_	_	_	_	_	_
43	responses	_	_	_	_	_	_	_	_
44	via	_	_	_	_	_	_	_	_
45	immunomodulation	_	_	_	_	_	_	_	_
46	.	_	_	_	_	_	_	_	_
47	The	_	_	_	_	_	_	_	BeginSeg=Yes
48	plasticity	_	_	_	_	_	_	_	_
49	of	_	_	_	_	_	_	_	_
50	MSCs	_	_	_	_	_	_	_	_
51	in	_	_	_	_	_	_	_	_
52	immunomodulation	_	_	_	_	_	_	_	_
53	allow	_	_	_	_	_	_	_	_
54	these	_	_	_	_	_	_	_	_
55	cells	_	_	_	_	_	_	_	_
56	to	_	_	_	_	_	_	_	_
57	exert	_	_	_	_	_	_	_	_
58	different	_	_	_	_	_	_	_	_
59	immune	_	_	_	_	_	_	_	_
60	effects	_	_	_	_	_	_	_	_
61	depending	_	_	_	_	_	_	_	BeginSeg=Yes
62	on	_	_	_	_	_	_	_	_
63	different	_	_	_	_	_	_	_	_
64	diseases	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
66	Understanding	_	_	_	_	_	_	_	BeginSeg=Yes
67	the	_	_	_	_	_	_	_	_
68	biology	_	_	_	_	_	_	_	_
69	of	_	_	_	_	_	_	_	_
70	MSCs	_	_	_	_	_	_	_	_
71	and	_	_	_	_	_	_	_	_
72	their	_	_	_	_	_	_	_	_
73	role	_	_	_	_	_	_	_	_
74	in	_	_	_	_	_	_	_	_
75	treatment	_	_	_	_	_	_	_	_
76	is	_	_	_	_	_	_	_	_
77	critical	_	_	_	_	_	_	_	_
78	to	_	_	_	_	_	_	_	BeginSeg=Yes
79	determine	_	_	_	_	_	_	_	_
80	their	_	_	_	_	_	_	_	_
81	potential	_	_	_	_	_	_	_	_
82	for	_	_	_	_	_	_	_	_
83	various	_	_	_	_	_	_	_	_
84	therapeutic	_	_	_	_	_	_	_	_
85	applications	_	_	_	_	_	_	_	_
86	and	_	_	_	_	_	_	_	_
87	for	_	_	_	_	_	_	_	_
88	the	_	_	_	_	_	_	_	_
89	development	_	_	_	_	_	_	_	_
90	of	_	_	_	_	_	_	_	_
91	MSC	_	_	_	_	_	_	_	_
92	-	_	_	_	_	_	_	_	_
93	based	_	_	_	_	_	_	_	_
94	regenerative	_	_	_	_	_	_	_	_
95	medicine	_	_	_	_	_	_	_	_
96	.	_	_	_	_	_	_	_	_
97	This	_	_	_	_	_	_	_	BeginSeg=Yes
98	review	_	_	_	_	_	_	_	_
99	summarizes	_	_	_	_	_	_	_	_
100	the	_	_	_	_	_	_	_	_
101	recent	_	_	_	_	_	_	_	_
102	progress	_	_	_	_	_	_	_	_
103	of	_	_	_	_	_	_	_	_
104	particular	_	_	_	_	_	_	_	_
105	mechanisms	_	_	_	_	_	_	_	_
106	underlying	_	_	_	_	_	_	_	BeginSeg=Yes
107	the	_	_	_	_	_	_	_	_
108	tissue	_	_	_	_	_	_	_	_
109	regenerative	_	_	_	_	_	_	_	_
110	properties	_	_	_	_	_	_	_	_
111	and	_	_	_	_	_	_	_	_
112	immunomodulatory	_	_	_	_	_	_	_	_
113	effects	_	_	_	_	_	_	_	_
114	of	_	_	_	_	_	_	_	_
115	MSCs	_	_	_	_	_	_	_	_
116	.	_	_	_	_	_	_	_	_
117	We	_	_	_	_	_	_	_	BeginSeg=Yes
118	focused	_	_	_	_	_	_	_	_
119	on	_	_	_	_	_	_	_	_
120	discussing	_	_	_	_	_	_	_	_
121	the	_	_	_	_	_	_	_	_
122	functional	_	_	_	_	_	_	_	_
123	roles	_	_	_	_	_	_	_	_
124	of	_	_	_	_	_	_	_	_
125	paracrine	_	_	_	_	_	_	_	_
126	activities	_	_	_	_	_	_	_	_
127	,	_	_	_	_	_	_	_	_
128	direct	_	_	_	_	_	_	_	_
129	cell	_	_	_	_	_	_	_	_
130	-	_	_	_	_	_	_	_	_
131	cell	_	_	_	_	_	_	_	_
132	contact	_	_	_	_	_	_	_	_
133	,	_	_	_	_	_	_	_	_
134	mitochondrial	_	_	_	_	_	_	_	_
135	transfer	_	_	_	_	_	_	_	_
136	,	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	_
138	extracellular	_	_	_	_	_	_	_	_
139	vesicles	_	_	_	_	_	_	_	_
140	related	_	_	_	_	_	_	_	BeginSeg=Yes
141	to	_	_	_	_	_	_	_	_
142	MSC	_	_	_	_	_	_	_	_
143	-	_	_	_	_	_	_	_	_
144	mediated	_	_	_	_	_	_	_	_
145	effects	_	_	_	_	_	_	_	_
146	on	_	_	_	_	_	_	_	_
147	immune	_	_	_	_	_	_	_	_
148	cell	_	_	_	_	_	_	_	_
149	responses	_	_	_	_	_	_	_	_
150	,	_	_	_	_	_	_	_	_
151	cell	_	_	_	_	_	_	_	_
152	survival	_	_	_	_	_	_	_	_
153	,	_	_	_	_	_	_	_	_
154	and	_	_	_	_	_	_	_	_
155	regeneration	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_
157	This	_	_	_	_	_	_	_	BeginSeg=Yes
158	will	_	_	_	_	_	_	_	_
159	provide	_	_	_	_	_	_	_	_
160	an	_	_	_	_	_	_	_	_
161	overview	_	_	_	_	_	_	_	_
162	of	_	_	_	_	_	_	_	_
163	the	_	_	_	_	_	_	_	_
164	current	_	_	_	_	_	_	_	_
165	research	_	_	_	_	_	_	_	_
166	on	_	_	_	_	_	_	_	_
167	the	_	_	_	_	_	_	_	_
168	rapid	_	_	_	_	_	_	_	_
169	development	_	_	_	_	_	_	_	_
170	of	_	_	_	_	_	_	_	_
171	MSC	_	_	_	_	_	_	_	_
172	-	_	_	_	_	_	_	_	_
173	based	_	_	_	_	_	_	_	_
174	therapies	_	_	_	_	_	_	_	_
175	.	_	_	_	_	_	_	_	_

# newdoc_id = 4395141eef1089f1c75a14912fade412fd694c19
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	glycosylated	_	_	_	_	_	_	_	_
3	membrane	_	_	_	_	_	_	_	_
4	protein	_	_	_	_	_	_	_	_
5	M	_	_	_	_	_	_	_	_
6	of	_	_	_	_	_	_	_	_
7	the	_	_	_	_	_	_	_	_
8	severe	_	_	_	_	_	_	_	_
9	acute	_	_	_	_	_	_	_	_
10	respiratory	_	_	_	_	_	_	_	_
11	syndrome	_	_	_	_	_	_	_	_
12	associated	_	_	_	_	_	_	_	_
13	coronavirus	_	_	_	_	_	_	_	_
14	(	_	_	_	_	_	_	_	_
15	SARS	_	_	_	_	_	_	_	_
16	-	_	_	_	_	_	_	_	_
17	CoV	_	_	_	_	_	_	_	_
18	)	_	_	_	_	_	_	_	_
19	is	_	_	_	_	_	_	_	_
20	the	_	_	_	_	_	_	_	_
21	main	_	_	_	_	_	_	_	_
22	structural	_	_	_	_	_	_	_	_
23	component	_	_	_	_	_	_	_	_
24	of	_	_	_	_	_	_	_	_
25	the	_	_	_	_	_	_	_	_
26	virion	_	_	_	_	_	_	_	_
27	and	_	_	_	_	_	_	_	BeginSeg=Yes
28	mediates	_	_	_	_	_	_	_	_
29	assembly	_	_	_	_	_	_	_	_
30	and	_	_	_	_	_	_	_	_
31	budding	_	_	_	_	_	_	_	_
32	of	_	_	_	_	_	_	_	_
33	viral	_	_	_	_	_	_	_	_
34	particles	_	_	_	_	_	_	_	_
35	.	_	_	_	_	_	_	_	_
36	The	_	_	_	_	_	_	_	BeginSeg=Yes
37	membrane	_	_	_	_	_	_	_	_
38	topology	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	SARS	_	_	_	_	_	_	_	_
41	-	_	_	_	_	_	_	_	_
42	CoV	_	_	_	_	_	_	_	_
43	M	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	_
45	the	_	_	_	_	_	_	_	_
46	functional	_	_	_	_	_	_	_	_
47	significance	_	_	_	_	_	_	_	_
48	of	_	_	_	_	_	_	_	_
49	its	_	_	_	_	_	_	_	_
50	N	_	_	_	_	_	_	_	_
51	-	_	_	_	_	_	_	_	_
52	glycosylation	_	_	_	_	_	_	_	_
53	are	_	_	_	_	_	_	_	_
54	not	_	_	_	_	_	_	_	_
55	completely	_	_	_	_	_	_	_	_
56	understood	_	_	_	_	_	_	_	_
57	as	_	_	_	_	_	_	_	BeginSeg=Yes
58	is	_	_	_	_	_	_	_	_
59	its	_	_	_	_	_	_	_	_
60	interaction	_	_	_	_	_	_	_	_
61	with	_	_	_	_	_	_	_	_
62	the	_	_	_	_	_	_	_	_
63	surface	_	_	_	_	_	_	_	_
64	glycoprotein	_	_	_	_	_	_	_	_
65	S.	_	_	_	_	_	_	_	_
66	Using	_	_	_	_	_	_	_	BeginSeg=Yes
67	biochemical	_	_	_	_	_	_	_	_
68	and	_	_	_	_	_	_	_	_
69	immunofluorescence	_	_	_	_	_	_	_	_
70	analyses	_	_	_	_	_	_	_	_
71	we	_	_	_	_	_	_	_	BeginSeg=Yes
72	found	_	_	_	_	_	_	_	_
73	that	_	_	_	_	_	_	_	BeginSeg=Yes
74	M	_	_	_	_	_	_	_	_
75	consists	_	_	_	_	_	_	_	_
76	of	_	_	_	_	_	_	_	_
77	a	_	_	_	_	_	_	_	_
78	short	_	_	_	_	_	_	_	_
79	glycosylated	_	_	_	_	_	_	_	_
80	N	_	_	_	_	_	_	_	_
81	-	_	_	_	_	_	_	_	_
82	terminal	_	_	_	_	_	_	_	_
83	ectodomain	_	_	_	_	_	_	_	_
84	,	_	_	_	_	_	_	_	_
85	three	_	_	_	_	_	_	_	_
86	transmembrane	_	_	_	_	_	_	_	_
87	segments	_	_	_	_	_	_	_	_
88	and	_	_	_	_	_	_	_	_
89	a	_	_	_	_	_	_	_	_
90	long	_	_	_	_	_	_	_	_
91	,	_	_	_	_	_	_	_	_
92	immunogenic	_	_	_	_	_	_	_	_
93	C	_	_	_	_	_	_	_	_
94	-	_	_	_	_	_	_	_	_
95	terminal	_	_	_	_	_	_	_	_
96	endodomain	_	_	_	_	_	_	_	_
97	.	_	_	_	_	_	_	_	_
98	Although	_	_	_	_	_	_	_	BeginSeg=Yes
99	the	_	_	_	_	_	_	_	_
100	N	_	_	_	_	_	_	_	_
101	-	_	_	_	_	_	_	_	_
102	glycosylation	_	_	_	_	_	_	_	_
103	site	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	M	_	_	_	_	_	_	_	_
106	seems	_	_	_	_	_	_	_	_
107	to	_	_	_	_	_	_	_	_
108	be	_	_	_	_	_	_	_	_
109	highly	_	_	_	_	_	_	_	_
110	conserved	_	_	_	_	_	_	_	_
111	between	_	_	_	_	_	_	_	_
112	group	_	_	_	_	_	_	_	_
113	1	_	_	_	_	_	_	_	_
114	and	_	_	_	_	_	_	_	_
115	3	_	_	_	_	_	_	_	_
116	coronaviruses	_	_	_	_	_	_	_	_
117	,	_	_	_	_	_	_	_	_
118	studies	_	_	_	_	_	_	_	BeginSeg=Yes
119	using	_	_	_	_	_	_	_	BeginSeg=Yes
120	a	_	_	_	_	_	_	_	_
121	recombinant	_	_	_	_	_	_	_	_
122	SARS	_	_	_	_	_	_	_	_
123	-	_	_	_	_	_	_	_	_
124	CoV	_	_	_	_	_	_	_	_
125	expressing	_	_	_	_	_	_	_	BeginSeg=Yes
126	a	_	_	_	_	_	_	_	_
127	glycosylation	_	_	_	_	_	_	_	_
128	-	_	_	_	_	_	_	_	_
129	deficient	_	_	_	_	_	_	_	_
130	M	_	_	_	_	_	_	_	_
131	revealed	_	_	_	_	_	_	_	BeginSeg=Yes
132	that	_	_	_	_	_	_	_	BeginSeg=Yes
133	N	_	_	_	_	_	_	_	_
134	-	_	_	_	_	_	_	_	_
135	glycosylation	_	_	_	_	_	_	_	_
136	of	_	_	_	_	_	_	_	_
137	M	_	_	_	_	_	_	_	_
138	neither	_	_	_	_	_	_	_	_
139	influence	_	_	_	_	_	_	_	_
140	the	_	_	_	_	_	_	_	_
141	shape	_	_	_	_	_	_	_	_
142	of	_	_	_	_	_	_	_	_
143	the	_	_	_	_	_	_	_	_
144	virions	_	_	_	_	_	_	_	_
145	nor	_	_	_	_	_	_	_	_
146	their	_	_	_	_	_	_	_	_
147	infectivity	_	_	_	_	_	_	_	_
148	in	_	_	_	_	_	_	_	_
149	cell	_	_	_	_	_	_	_	_
150	culture	_	_	_	_	_	_	_	_
151	.	_	_	_	_	_	_	_	_
152	Further	_	_	_	_	_	_	_	BeginSeg=Yes
153	functional	_	_	_	_	_	_	_	_
154	analysis	_	_	_	_	_	_	_	_
155	of	_	_	_	_	_	_	_	_
156	truncated	_	_	_	_	_	_	_	_
157	M	_	_	_	_	_	_	_	_
158	proteins	_	_	_	_	_	_	_	_
159	showed	_	_	_	_	_	_	_	_
160	that	_	_	_	_	_	_	_	BeginSeg=Yes
161	the	_	_	_	_	_	_	_	_
162	N	_	_	_	_	_	_	_	_
163	-	_	_	_	_	_	_	_	_
164	terminal	_	_	_	_	_	_	_	_
165	134	_	_	_	_	_	_	_	_
166	amino	_	_	_	_	_	_	_	_
167	acids	_	_	_	_	_	_	_	_
168	comprising	_	_	_	_	_	_	_	BeginSeg=Yes
169	the	_	_	_	_	_	_	_	_
170	three	_	_	_	_	_	_	_	_
171	transmembrane	_	_	_	_	_	_	_	_
172	domains	_	_	_	_	_	_	_	_
173	are	_	_	_	_	_	_	_	BeginSeg=Yes
174	sufficient	_	_	_	_	_	_	_	_
175	to	_	_	_	_	_	_	_	BeginSeg=Yes
176	mediate	_	_	_	_	_	_	_	_
177	accumulation	_	_	_	_	_	_	_	_
178	of	_	_	_	_	_	_	_	_
179	M	_	_	_	_	_	_	_	_
180	in	_	_	_	_	_	_	_	_
181	the	_	_	_	_	_	_	_	_
182	Golgi	_	_	_	_	_	_	_	_
183	complex	_	_	_	_	_	_	_	_
184	and	_	_	_	_	_	_	_	BeginSeg=Yes
185	to	_	_	_	_	_	_	_	_
186	enforce	_	_	_	_	_	_	_	_
187	recruitment	_	_	_	_	_	_	_	_
188	of	_	_	_	_	_	_	_	_
189	the	_	_	_	_	_	_	_	_
190	viral	_	_	_	_	_	_	_	_
191	spike	_	_	_	_	_	_	_	_
192	protein	_	_	_	_	_	_	_	_
193	S	_	_	_	_	_	_	_	_
194	to	_	_	_	_	_	_	_	_
195	the	_	_	_	_	_	_	_	_
196	sites	_	_	_	_	_	_	_	_
197	of	_	_	_	_	_	_	_	_
198	virus	_	_	_	_	_	_	_	_
199	assembly	_	_	_	_	_	_	_	_
200	and	_	_	_	_	_	_	_	_
201	budding	_	_	_	_	_	_	_	_
202	in	_	_	_	_	_	_	_	_
203	the	_	_	_	_	_	_	_	_
204	ERGIC	_	_	_	_	_	_	_	_
205	.	_	_	_	_	_	_	_	_

# newdoc_id = 43b340eb1776b4c487c7893797fd744fc3fdb04e
1	In	_	_	_	_	_	_	_	BeginSeg=Yes
2	this	_	_	_	_	_	_	_	_
3	paper	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	we	_	_	_	_	_	_	_	_
6	suggest	_	_	_	_	_	_	_	_
7	a	_	_	_	_	_	_	_	_
8	real	_	_	_	_	_	_	_	_
9	-	_	_	_	_	_	_	_	_
10	time	_	_	_	_	_	_	_	_
11	online	_	_	_	_	_	_	_	_
12	shopper	_	_	_	_	_	_	_	_
13	behavior	_	_	_	_	_	_	_	_
14	prediction	_	_	_	_	_	_	_	_
15	system	_	_	_	_	_	_	_	_
16	which	_	_	_	_	_	_	_	BeginSeg=Yes
17	predicts	_	_	_	_	_	_	_	_
18	the	_	_	_	_	_	_	_	_
19-20	visitor's	_	_	_	_	_	_	_	_
19	visitor	_	_	_	_	_	_	_	_
20	's	_	_	_	_	_	_	_	_
21	shopping	_	_	_	_	_	_	_	_
22	intent	_	_	_	_	_	_	_	_
23	as	_	_	_	_	_	_	_	BeginSeg=Yes
24	soon	_	_	_	_	_	_	_	_
25	as	_	_	_	_	_	_	_	_
26	the	_	_	_	_	_	_	_	_
27	website	_	_	_	_	_	_	_	_
28	is	_	_	_	_	_	_	_	_
29	visited	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	To	_	_	_	_	_	_	_	BeginSeg=Yes
32	do	_	_	_	_	_	_	_	_
33	that	_	_	_	_	_	_	_	_
34	,	_	_	_	_	_	_	_	_
35	we	_	_	_	_	_	_	_	BeginSeg=Yes
36	rely	_	_	_	_	_	_	_	_
37	on	_	_	_	_	_	_	_	_
38	session	_	_	_	_	_	_	_	_
39	and	_	_	_	_	_	_	_	_
40	visitor	_	_	_	_	_	_	_	_
41	information	_	_	_	_	_	_	_	_
42	and	_	_	_	_	_	_	_	BeginSeg=Yes
43	we	_	_	_	_	_	_	_	_
44	investigate	_	_	_	_	_	_	_	_
45	naïve	_	_	_	_	_	_	_	_
46	Bayes	_	_	_	_	_	_	_	_
47	classifier	_	_	_	_	_	_	_	_
48	,	_	_	_	_	_	_	_	_
49	C4.5	_	_	_	_	_	_	_	_
50	decision	_	_	_	_	_	_	_	_
51	tree	_	_	_	_	_	_	_	_
52	and	_	_	_	_	_	_	_	_
53	random	_	_	_	_	_	_	_	_
54	forest	_	_	_	_	_	_	_	_
55	.	_	_	_	_	_	_	_	_
56	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
57	,	_	_	_	_	_	_	_	_
58	we	_	_	_	_	_	_	_	_
59	use	_	_	_	_	_	_	_	_
60	oversampling	_	_	_	_	_	_	_	_
61	to	_	_	_	_	_	_	_	BeginSeg=Yes
62	improve	_	_	_	_	_	_	_	_
63	the	_	_	_	_	_	_	_	_
64	performance	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	_
66	the	_	_	_	_	_	_	_	_
67	scalability	_	_	_	_	_	_	_	_
68	of	_	_	_	_	_	_	_	_
69	each	_	_	_	_	_	_	_	_
70	classifier	_	_	_	_	_	_	_	_
71	.	_	_	_	_	_	_	_	_
72	The	_	_	_	_	_	_	_	BeginSeg=Yes
73	results	_	_	_	_	_	_	_	_
74	show	_	_	_	_	_	_	_	_
75	that	_	_	_	_	_	_	_	BeginSeg=Yes
76	random	_	_	_	_	_	_	_	_
77	forest	_	_	_	_	_	_	_	_
78	produces	_	_	_	_	_	_	_	_
79	significantly	_	_	_	_	_	_	_	_
80	higher	_	_	_	_	_	_	_	_
81	accuracy	_	_	_	_	_	_	_	_
82	and	_	_	_	_	_	_	_	_
83	F1	_	_	_	_	_	_	_	_
84	Score	_	_	_	_	_	_	_	_
85	than	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	compared	_	_	_	_	_	_	_	_
88	techniques	_	_	_	_	_	_	_	_
89	.	_	_	_	_	_	_	_	_

# newdoc_id = 43c284998733a1d7cc474d14c378f08e4b509c63
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	mosquito	_	_	_	_	_	_	_	_
3	-	_	_	_	_	_	_	_	_
4	borne	_	_	_	_	_	_	_	_
5	chikungunya	_	_	_	_	_	_	_	_
6	virus	_	_	_	_	_	_	_	_
7	(	_	_	_	_	_	_	_	_
8	CHIKV	_	_	_	_	_	_	_	_
9	)	_	_	_	_	_	_	_	_
10	causes	_	_	_	_	_	_	_	_
11	chikungunya	_	_	_	_	_	_	_	_
12	fever	_	_	_	_	_	_	_	_
13	,	_	_	_	_	_	_	_	_
14	with	_	_	_	_	_	_	_	_
15	clinical	_	_	_	_	_	_	_	_
16	presentations	_	_	_	_	_	_	_	_
17	such	_	_	_	_	_	_	_	BeginSeg=Yes
18	as	_	_	_	_	_	_	_	_
19	severe	_	_	_	_	_	_	_	_
20	back	_	_	_	_	_	_	_	_
21	and	_	_	_	_	_	_	_	_
22	small	_	_	_	_	_	_	_	_
23	joint	_	_	_	_	_	_	_	_
24	pain	_	_	_	_	_	_	_	_
25	,	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	debilitating	_	_	_	_	_	_	_	_
28	arthritis	_	_	_	_	_	_	_	_
29	associated	_	_	_	_	_	_	_	BeginSeg=Yes
30	with	_	_	_	_	_	_	_	_
31	crippling	_	_	_	_	_	_	_	_
32	pains	_	_	_	_	_	_	_	_
33	that	_	_	_	_	_	_	_	BeginSeg=Yes
34	persist	_	_	_	_	_	_	_	_
35	for	_	_	_	_	_	_	_	_
36	weeks	_	_	_	_	_	_	_	_
37	and	_	_	_	_	_	_	_	_
38	even	_	_	_	_	_	_	_	_
39	years	_	_	_	_	_	_	_	_
40	.	_	_	_	_	_	_	_	_
41	Although	_	_	_	_	_	_	_	BeginSeg=Yes
42	there	_	_	_	_	_	_	_	_
43	are	_	_	_	_	_	_	_	_
44	several	_	_	_	_	_	_	_	_
45	studies	_	_	_	_	_	_	_	_
46	to	_	_	_	_	_	_	_	BeginSeg=Yes
47	evaluate	_	_	_	_	_	_	_	_
48	the	_	_	_	_	_	_	_	_
49	efficacy	_	_	_	_	_	_	_	_
50	of	_	_	_	_	_	_	_	_
51	drugs	_	_	_	_	_	_	_	_
52	against	_	_	_	_	_	_	_	_
53	CHIKV	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	BeginSeg=Yes
56	treatment	_	_	_	_	_	_	_	_
57	for	_	_	_	_	_	_	_	_
58	chikungunya	_	_	_	_	_	_	_	_
59	fever	_	_	_	_	_	_	_	_
60	is	_	_	_	_	_	_	_	_
61	mainly	_	_	_	_	_	_	_	_
62	symptom	_	_	_	_	_	_	_	_
63	-	_	_	_	_	_	_	_	_
64	based	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	BeginSeg=Yes
66	no	_	_	_	_	_	_	_	_
67	effective	_	_	_	_	_	_	_	_
68	licensed	_	_	_	_	_	_	_	_
69	vaccine	_	_	_	_	_	_	_	_
70	or	_	_	_	_	_	_	_	_
71	antiviral	_	_	_	_	_	_	_	_
72	are	_	_	_	_	_	_	_	_
73	available	_	_	_	_	_	_	_	_
74	.	_	_	_	_	_	_	_	_
75	Here	_	_	_	_	_	_	_	BeginSeg=Yes
76	,	_	_	_	_	_	_	_	_
77	we	_	_	_	_	_	_	_	_
78	investigated	_	_	_	_	_	_	_	_
79	the	_	_	_	_	_	_	_	_
80	antiviral	_	_	_	_	_	_	_	_
81	activity	_	_	_	_	_	_	_	_
82	of	_	_	_	_	_	_	_	_
83	three	_	_	_	_	_	_	_	_
84	types	_	_	_	_	_	_	_	_
85	of	_	_	_	_	_	_	_	_
86	flavonoids	_	_	_	_	_	_	_	_
87	against	_	_	_	_	_	_	_	_
88	CHIKV	_	_	_	_	_	_	_	_
89	in	_	_	_	_	_	_	_	_
90	vitro	_	_	_	_	_	_	_	_
91	replication	_	_	_	_	_	_	_	_
92	.	_	_	_	_	_	_	_	_
93	Three	_	_	_	_	_	_	_	BeginSeg=Yes
94	compounds	_	_	_	_	_	_	_	_
95	:	_	_	_	_	_	_	_	_
96	silymarin	_	_	_	_	_	_	_	BeginSeg=Yes
97	,	_	_	_	_	_	_	_	_
98	quercetin	_	_	_	_	_	_	_	_
99	and	_	_	_	_	_	_	_	_
100	kaempferol	_	_	_	_	_	_	_	_
101	were	_	_	_	_	_	_	_	BeginSeg=Yes
102	evaluated	_	_	_	_	_	_	_	_
103	for	_	_	_	_	_	_	_	_
104	their	_	_	_	_	_	_	_	_
105	in	_	_	_	_	_	_	_	_
106	vitro	_	_	_	_	_	_	_	_
107	antiviral	_	_	_	_	_	_	_	_
108	activities	_	_	_	_	_	_	_	_
109	against	_	_	_	_	_	_	_	_
110	CHIKV	_	_	_	_	_	_	_	_
111	using	_	_	_	_	_	_	_	BeginSeg=Yes
112	a	_	_	_	_	_	_	_	_
113	CHIKV	_	_	_	_	_	_	_	_
114	replicon	_	_	_	_	_	_	_	_
115	cell	_	_	_	_	_	_	_	_
116	line	_	_	_	_	_	_	_	_
117	and	_	_	_	_	_	_	_	_
118	clinical	_	_	_	_	_	_	_	_
119	isolate	_	_	_	_	_	_	_	_
120	of	_	_	_	_	_	_	_	_
121	CHIKV	_	_	_	_	_	_	_	_
122	of	_	_	_	_	_	_	_	_
123	Central	_	_	_	_	_	_	_	_
124	/	_	_	_	_	_	_	_	_
125	East	_	_	_	_	_	_	_	_
126	African	_	_	_	_	_	_	_	_
127	genotype	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	A	_	_	_	_	_	_	_	BeginSeg=Yes
130	cytopathic	_	_	_	_	_	_	_	_
131	effect	_	_	_	_	_	_	_	_
132	inhibition	_	_	_	_	_	_	_	_
133	assay	_	_	_	_	_	_	_	_
134	was	_	_	_	_	_	_	_	_
135	used	_	_	_	_	_	_	_	_
136	to	_	_	_	_	_	_	_	BeginSeg=Yes
137	determine	_	_	_	_	_	_	_	_
138	their	_	_	_	_	_	_	_	_
139	activities	_	_	_	_	_	_	_	_
140	on	_	_	_	_	_	_	_	_
141	CHIKV	_	_	_	_	_	_	_	_
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58	novel	_	_	_	_	_	_	_	_
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94	understand	_	_	_	_	_	_	_	_
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157	analysis	_	_	_	_	_	_	_	_
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229	influenza	_	_	_	_	_	_	_	_
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289	at	_	_	_	_	_	_	_	_
290	:	_	_	_	_	_	_	_	_

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131	were	_	_	_	_	_	_	_	_
132	further	_	_	_	_	_	_	_	_
133	subdivided	_	_	_	_	_	_	_	_
134	in	_	_	_	_	_	_	_	_
135	epitopes	_	_	_	_	_	_	_	_
136	.	_	_	_	_	_	_	_	_
137	A	_	_	_	_	_	_	_	BeginSeg=Yes
138	total	_	_	_	_	_	_	_	_
139	of	_	_	_	_	_	_	_	_
140	11	_	_	_	_	_	_	_	_
141	epitopes	_	_	_	_	_	_	_	_
142	were	_	_	_	_	_	_	_	_
143	defined	_	_	_	_	_	_	_	_
144	in	_	_	_	_	_	_	_	_
145	E2	_	_	_	_	_	_	_	_
146	glycoprotein	_	_	_	_	_	_	_	_
147	,	_	_	_	_	_	_	_	_
148	eight	_	_	_	_	_	_	_	BeginSeg=Yes
149	of	_	_	_	_	_	_	_	_
150	which	_	_	_	_	_	_	_	_
151	were	_	_	_	_	_	_	_	_
152	critical	_	_	_	_	_	_	_	_
153	for	_	_	_	_	_	_	_	_
154	virus	_	_	_	_	_	_	_	_
155	neutralization	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_
157	Neutralizing	_	_	_	_	_	_	_	BeginSeg=Yes
158	MAbs	_	_	_	_	_	_	_	_
159	were	_	_	_	_	_	_	_	_
160	obtained	_	_	_	_	_	_	_	_
161	only	_	_	_	_	_	_	_	BeginSeg=Yes
162	when	_	_	_	_	_	_	_	_
163	native	_	_	_	_	_	_	_	_
164	virus	_	_	_	_	_	_	_	_
165	was	_	_	_	_	_	_	_	_
166	used	_	_	_	_	_	_	_	_
167	to	_	_	_	_	_	_	_	BeginSeg=Yes
168	immunize	_	_	_	_	_	_	_	_
169	mice	_	_	_	_	_	_	_	_
170	,	_	_	_	_	_	_	_	_
171	although	_	_	_	_	_	_	_	BeginSeg=Yes
172	to	_	_	_	_	_	_	_	BeginSeg=Yes
173	produce	_	_	_	_	_	_	_	_
174	hybridomas	_	_	_	_	_	_	_	_
175	mice	_	_	_	_	_	_	_	_
176	immunizations	_	_	_	_	_	_	_	BeginSeg=Yes
177	were	_	_	_	_	_	_	_	_
178	made	_	_	_	_	_	_	_	_
179	with	_	_	_	_	_	_	_	_
180	antigen	_	_	_	_	_	_	_	_
181	in	_	_	_	_	_	_	_	_
182	the	_	_	_	_	_	_	_	_
183	native	_	_	_	_	_	_	_	_
184	,	_	_	_	_	_	_	_	_
185	denatured	_	_	_	_	_	_	_	_
186	,	_	_	_	_	_	_	_	_
187	or	_	_	_	_	_	_	_	_
188	mixtures	_	_	_	_	_	_	_	_
189	of	_	_	_	_	_	_	_	_
190	native	_	_	_	_	_	_	_	_
191	and	_	_	_	_	_	_	_	_
192	denatured	_	_	_	_	_	_	_	_
193	form	_	_	_	_	_	_	_	_
194	.	_	_	_	_	_	_	_	_
195	All	_	_	_	_	_	_	_	BeginSeg=Yes
196	neutralizing	_	_	_	_	_	_	_	_
197	MAbs	_	_	_	_	_	_	_	_
198	reacted	_	_	_	_	_	_	_	_
199	to	_	_	_	_	_	_	_	_
200	conformational	_	_	_	_	_	_	_	_
201	epitopes	_	_	_	_	_	_	_	_
202	.	_	_	_	_	_	_	_	_
203	The	_	_	_	_	_	_	_	BeginSeg=Yes
204	antigenic	_	_	_	_	_	_	_	_
205	structure	_	_	_	_	_	_	_	_
206	of	_	_	_	_	_	_	_	_
207	the	_	_	_	_	_	_	_	_
208	EZglycoprotein	_	_	_	_	_	_	_	_
209	has	_	_	_	_	_	_	_	_
210	been	_	_	_	_	_	_	_	_
211	defined	_	_	_	_	_	_	_	_
212	with	_	_	_	_	_	_	_	_
213	murine	_	_	_	_	_	_	_	_
214	MAbs	_	_	_	_	_	_	_	_
215	,	_	_	_	_	_	_	_	_
216	but	_	_	_	_	_	_	_	BeginSeg=Yes
217	the	_	_	_	_	_	_	_	_
218	antigenic	_	_	_	_	_	_	_	_
219	sites	_	_	_	_	_	_	_	_
220	were	_	_	_	_	_	_	_	_
221	relevant	_	_	_	_	_	_	_	_
222	in	_	_	_	_	_	_	_	_
223	the	_	_	_	_	_	_	_	_
224	swine	_	_	_	_	_	_	_	_
225	,	_	_	_	_	_	_	_	_
226	the	_	_	_	_	_	_	_	_
227	natural	_	_	_	_	_	_	_	_
228	host	_	_	_	_	_	_	_	_
229	of	_	_	_	_	_	_	_	_
230	the	_	_	_	_	_	_	_	_
231	virus	_	_	_	_	_	_	_	_
232	,	_	_	_	_	_	_	_	_
233	because	_	_	_	_	_	_	_	BeginSeg=Yes
234	porcine	_	_	_	_	_	_	_	_
235	sera	_	_	_	_	_	_	_	_
236	reacted	_	_	_	_	_	_	_	_
237	against	_	_	_	_	_	_	_	_
238	these	_	_	_	_	_	_	_	_
239	sites	_	_	_	_	_	_	_	_
240	.	_	_	_	_	_	_	_	_
241	MAbs	_	_	_	_	_	_	_	BeginSeg=Yes
242	specific	_	_	_	_	_	_	_	_
243	for	_	_	_	_	_	_	_	_
244	TGE	_	_	_	_	_	_	_	_
245	virus	_	_	_	_	_	_	_	_
246	site	_	_	_	_	_	_	_	_
247	C	_	_	_	_	_	_	_	_
248	reacted	_	_	_	_	_	_	_	_
249	to	_	_	_	_	_	_	_	_
250	non	_	_	_	_	_	_	_	_
251	-	_	_	_	_	_	_	_	_
252	immune	_	_	_	_	_	_	_	_
253	porcine	_	_	_	_	_	_	_	_
254	sera	_	_	_	_	_	_	_	_
255	.	_	_	_	_	_	_	_	_
256	This	_	_	_	_	_	_	_	BeginSeg=Yes
257	reactivity	_	_	_	_	_	_	_	_
258	was	_	_	_	_	_	_	_	_
259	not	_	_	_	_	_	_	_	_
260	directed	_	_	_	_	_	_	_	_
261	against	_	_	_	_	_	_	_	_
262	porcine	_	_	_	_	_	_	_	_
263	immunoglobulins	_	_	_	_	_	_	_	_
264	.	_	_	_	_	_	_	_	_
265	These	_	_	_	_	_	_	_	BeginSeg=Yes
266	results	_	_	_	_	_	_	_	_
267	indicated	_	_	_	_	_	_	_	_
268	that	_	_	_	_	_	_	_	BeginSeg=Yes
269	TGE	_	_	_	_	_	_	_	_
270	virus	_	_	_	_	_	_	_	_
271	contains	_	_	_	_	_	_	_	_
272	epitope(s	_	_	_	_	_	_	_	_
273	)	_	_	_	_	_	_	_	_
274	also	_	_	_	_	_	_	_	_
275	present	_	_	_	_	_	_	_	_
276	in	_	_	_	_	_	_	_	_
277	some	_	_	_	_	_	_	_	_
278	non	_	_	_	_	_	_	_	_
279	-	_	_	_	_	_	_	_	_
280	immunoglobulin	_	_	_	_	_	_	_	_
281	component	_	_	_	_	_	_	_	_
282	of	_	_	_	_	_	_	_	_
283	porcine	_	_	_	_	_	_	_	_
284	serum	_	_	_	_	_	_	_	_
285	.	_	_	_	_	_	_	_	_

# newdoc_id = 45edbd85cb93950fecbc8da86f684a9e45c1d8f1
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	control	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	infectious	_	_	_	_	_	_	_	_
5	diseases	_	_	_	_	_	_	_	_
6	such	_	_	_	_	_	_	_	BeginSeg=Yes
7	as	_	_	_	_	_	_	_	_
8	swine	_	_	_	_	_	_	_	_
9	influenza	_	_	_	_	_	_	_	_
10	viruses	_	_	_	_	_	_	_	_
11	(	_	_	_	_	_	_	_	_
12	SwIV	_	_	_	_	_	_	_	_
13	)	_	_	_	_	_	_	_	_
14	plays	_	_	_	_	_	_	_	BeginSeg=Yes
15	an	_	_	_	_	_	_	_	_
16	important	_	_	_	_	_	_	_	_
17	role	_	_	_	_	_	_	_	_
18	in	_	_	_	_	_	_	_	_
19	food	_	_	_	_	_	_	_	_
20	production	_	_	_	_	_	_	_	_
21	both	_	_	_	_	_	_	_	_
22	from	_	_	_	_	_	_	_	_
23	the	_	_	_	_	_	_	_	_
24	animal	_	_	_	_	_	_	_	_
25	health	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	from	_	_	_	_	_	_	_	_
28	the	_	_	_	_	_	_	_	_
29	public	_	_	_	_	_	_	_	_
30	health	_	_	_	_	_	_	_	_
31	point	_	_	_	_	_	_	_	_
32	of	_	_	_	_	_	_	_	_
33	view	_	_	_	_	_	_	_	_
34	.	_	_	_	_	_	_	_	_
35	Probiotic	_	_	_	_	_	_	_	BeginSeg=Yes
36	microorganisms	_	_	_	_	_	_	_	_
37	and	_	_	_	_	_	_	_	_
38	other	_	_	_	_	_	_	_	_
39	health	_	_	_	_	_	_	_	_
40	improving	_	_	_	_	_	_	_	_
41	food	_	_	_	_	_	_	_	_
42	supplements	_	_	_	_	_	_	_	_
43	have	_	_	_	_	_	_	_	_
44	been	_	_	_	_	_	_	_	_
45	given	_	_	_	_	_	_	_	_
46	increasing	_	_	_	_	_	_	_	_
47	attention	_	_	_	_	_	_	_	_
48	in	_	_	_	_	_	_	_	_
49	recent	_	_	_	_	_	_	_	_
50	years	_	_	_	_	_	_	_	_
51	,	_	_	_	_	_	_	_	_
52	but	_	_	_	_	_	_	_	BeginSeg=Yes
53	,	_	_	_	_	_	_	_	_
54	no	_	_	_	_	_	_	_	_
55	information	_	_	_	_	_	_	_	_
56	on	_	_	_	_	_	_	_	_
57	the	_	_	_	_	_	_	_	_
58	effects	_	_	_	_	_	_	_	_
59	of	_	_	_	_	_	_	_	_
60	probiotics	_	_	_	_	_	_	_	_
61	on	_	_	_	_	_	_	_	_
62	swine	_	_	_	_	_	_	_	_
63	influenza	_	_	_	_	_	_	_	_
64	virus	_	_	_	_	_	_	_	_
65	is	_	_	_	_	_	_	_	_
66	available	_	_	_	_	_	_	_	_
67	.	_	_	_	_	_	_	_	_
68	Here	_	_	_	_	_	_	_	BeginSeg=Yes
69	we	_	_	_	_	_	_	_	_
70	address	_	_	_	_	_	_	_	_
71	this	_	_	_	_	_	_	_	_
72	question	_	_	_	_	_	_	_	_
73	by	_	_	_	_	_	_	_	BeginSeg=Yes
74	assessing	_	_	_	_	_	_	_	_
75	the	_	_	_	_	_	_	_	_
76	inhibitory	_	_	_	_	_	_	_	_
77	potential	_	_	_	_	_	_	_	_
78	of	_	_	_	_	_	_	_	_
79	the	_	_	_	_	_	_	_	_
80	probiotic	_	_	_	_	_	_	_	_
81	Enterococcus	_	_	_	_	_	_	_	_
82	faecium	_	_	_	_	_	_	_	_
83	NCIMB	_	_	_	_	_	_	_	_
84	10415	_	_	_	_	_	_	_	_
85	(	_	_	_	_	_	_	_	_
86	E.	_	_	_	_	_	_	_	_
87	faecium	_	_	_	_	_	_	_	_
88	)	_	_	_	_	_	_	_	_
89	on	_	_	_	_	_	_	_	_
90	the	_	_	_	_	_	_	_	_
91	replication	_	_	_	_	_	_	_	_
92	of	_	_	_	_	_	_	_	_
93	two	_	_	_	_	_	_	_	_
94	porcine	_	_	_	_	_	_	_	_
95	strains	_	_	_	_	_	_	_	_
96	of	_	_	_	_	_	_	_	_
97	influenza	_	_	_	_	_	_	_	_
98	virus	_	_	_	_	_	_	_	_
99	(	_	_	_	_	_	_	_	BeginSeg=Yes
100	H1N1	_	_	_	_	_	_	_	_
101	and	_	_	_	_	_	_	_	_
102	H3N2	_	_	_	_	_	_	_	_
103	strain	_	_	_	_	_	_	_	_
104	)	_	_	_	_	_	_	_	_
105	in	_	_	_	_	_	_	_	BeginSeg=Yes
106	a	_	_	_	_	_	_	_	_
107	continuous	_	_	_	_	_	_	_	_
108	porcine	_	_	_	_	_	_	_	_
109	macrophage	_	_	_	_	_	_	_	_
110	cell	_	_	_	_	_	_	_	_
111	line	_	_	_	_	_	_	_	_
112	(	_	_	_	_	_	_	_	BeginSeg=Yes
113	3D4/21	_	_	_	_	_	_	_	_
114	)	_	_	_	_	_	_	_	_
115	and	_	_	_	_	_	_	_	BeginSeg=Yes
116	in	_	_	_	_	_	_	_	_
117	MDBK	_	_	_	_	_	_	_	_
118	cells	_	_	_	_	_	_	_	_
119	.	_	_	_	_	_	_	_	_
120	Cell	_	_	_	_	_	_	_	BeginSeg=Yes
121	cultures	_	_	_	_	_	_	_	_
122	were	_	_	_	_	_	_	_	_
123	treated	_	_	_	_	_	_	_	_
124	with	_	_	_	_	_	_	_	_
125	E.	_	_	_	_	_	_	_	_
126	faecium	_	_	_	_	_	_	_	_
127	at	_	_	_	_	_	_	_	_
128	the	_	_	_	_	_	_	_	_
129	nontoxic	_	_	_	_	_	_	_	_
130	concentration	_	_	_	_	_	_	_	_
131	of	_	_	_	_	_	_	_	_
132	1610	_	_	_	_	_	_	_	_
133	6	_	_	_	_	_	_	_	_
134	CFU	_	_	_	_	_	_	_	_
135	/	_	_	_	_	_	_	_	_
136	ml	_	_	_	_	_	_	_	_
137	in	_	_	_	_	_	_	_	_
138	growth	_	_	_	_	_	_	_	_
139	medium	_	_	_	_	_	_	_	_
140	for	_	_	_	_	_	_	_	_
141	60	_	_	_	_	_	_	_	_
142	to	_	_	_	_	_	_	_	_
143	90	_	_	_	_	_	_	_	_
144	min	_	_	_	_	_	_	_	_
145	before	_	_	_	_	_	_	_	_
146	,	_	_	_	_	_	_	_	_
147	during	_	_	_	_	_	_	_	_
148	and	_	_	_	_	_	_	_	_
149	after	_	_	_	_	_	_	_	_
150	SwIV	_	_	_	_	_	_	_	_
151	infection	_	_	_	_	_	_	_	_
152	.	_	_	_	_	_	_	_	_
153	After	_	_	_	_	_	_	_	BeginSeg=Yes
154	further	_	_	_	_	_	_	_	_
155	incubation	_	_	_	_	_	_	_	_
156	of	_	_	_	_	_	_	_	_
157	cultures	_	_	_	_	_	_	_	_
158	in	_	_	_	_	_	_	_	_
159	probiotic	_	_	_	_	_	_	_	_
160	-	_	_	_	_	_	_	_	_
161	free	_	_	_	_	_	_	_	_
162	growth	_	_	_	_	_	_	_	_
163	medium	_	_	_	_	_	_	_	_
164	,	_	_	_	_	_	_	_	_
165	cell	_	_	_	_	_	_	_	_
166	viability	_	_	_	_	_	_	_	_
167	and	_	_	_	_	_	_	_	_
168	virus	_	_	_	_	_	_	_	_
169	propagation	_	_	_	_	_	_	_	_
170	were	_	_	_	_	_	_	_	_
171	determined	_	_	_	_	_	_	_	_
172	at	_	_	_	_	_	_	_	_
173	48	_	_	_	_	_	_	_	_
174	h	_	_	_	_	_	_	_	_
175	or	_	_	_	_	_	_	_	_
176	96	_	_	_	_	_	_	_	_
177	h	_	_	_	_	_	_	_	_
178	post	_	_	_	_	_	_	_	_
179	infection	_	_	_	_	_	_	_	_
180	.	_	_	_	_	_	_	_	_
181	The	_	_	_	_	_	_	_	BeginSeg=Yes
182	results	_	_	_	_	_	_	_	_
183	obtained	_	_	_	_	_	_	_	BeginSeg=Yes
184	reveal	_	_	_	_	_	_	_	BeginSeg=Yes
185	an	_	_	_	_	_	_	_	_
186	almost	_	_	_	_	_	_	_	_
187	complete	_	_	_	_	_	_	_	_
188	recovery	_	_	_	_	_	_	_	_
189	of	_	_	_	_	_	_	_	_
190	viability	_	_	_	_	_	_	_	_
191	of	_	_	_	_	_	_	_	_
192	SwIV	_	_	_	_	_	_	_	_
193	infected	_	_	_	_	_	_	_	_
194	cells	_	_	_	_	_	_	_	_
195	and	_	_	_	_	_	_	_	_
196	an	_	_	_	_	_	_	_	_
197	inhibition	_	_	_	_	_	_	_	_
198	of	_	_	_	_	_	_	_	_
199	virus	_	_	_	_	_	_	_	_
200	multiplication	_	_	_	_	_	_	_	_
201	by	_	_	_	_	_	_	_	_
202	up	_	_	_	_	_	_	_	_
203	to	_	_	_	_	_	_	_	_
204	four	_	_	_	_	_	_	_	_
205	log	_	_	_	_	_	_	_	_
206	units	_	_	_	_	_	_	_	_
207	in	_	_	_	_	_	_	_	_
208	the	_	_	_	_	_	_	_	_
209	E.	_	_	_	_	_	_	_	_
210	faecium	_	_	_	_	_	_	_	_
211	treated	_	_	_	_	_	_	_	_
212	cells	_	_	_	_	_	_	_	_
213	.	_	_	_	_	_	_	_	_
214	In	_	_	_	_	_	_	_	BeginSeg=Yes
215	both	_	_	_	_	_	_	_	_
216	3D4/21-and	_	_	_	_	_	_	_	_
217	MDBK	_	_	_	_	_	_	_	_
218	-	_	_	_	_	_	_	_	_
219	cells	_	_	_	_	_	_	_	_
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221	60	_	_	_	_	_	_	_	_
222	min	_	_	_	_	_	_	_	_
223	treatment	_	_	_	_	_	_	_	_
224	with	_	_	_	_	_	_	_	_
225	E.	_	_	_	_	_	_	_	_
226	faecium	_	_	_	_	_	_	_	_
227	stimulated	_	_	_	_	_	_	_	_
228	nitric	_	_	_	_	_	_	_	_
229	oxide	_	_	_	_	_	_	_	_
230	(	_	_	_	_	_	_	_	_
231	NO	_	_	_	_	_	_	_	_
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233	release	_	_	_	_	_	_	_	_
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235	is	_	_	_	_	_	_	_	_
236	in	_	_	_	_	_	_	_	_
237	line	_	_	_	_	_	_	_	_
238	with	_	_	_	_	_	_	_	_
239	published	_	_	_	_	_	_	_	_
240	evidence	_	_	_	_	_	_	_	_
241	for	_	_	_	_	_	_	_	_
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244	function	_	_	_	_	_	_	_	_
245	of	_	_	_	_	_	_	_	_
246	NO	_	_	_	_	_	_	_	_
247	.	_	_	_	_	_	_	_	_
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249	,	_	_	_	_	_	_	_	_
250	E.	_	_	_	_	_	_	_	_
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255	cellular	_	_	_	_	_	_	_	_
256	expression	_	_	_	_	_	_	_	_
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258	selected	_	_	_	_	_	_	_	_
259	mediators	_	_	_	_	_	_	_	_
260	of	_	_	_	_	_	_	_	_
261	defence	_	_	_	_	_	_	_	_
262	in	_	_	_	_	_	_	_	_
263	3D4-cells	_	_	_	_	_	_	_	_
264	:	_	_	_	_	_	_	_	_
265	while	_	_	_	_	_	_	_	BeginSeg=Yes
266	the	_	_	_	_	_	_	_	_
267	expression	_	_	_	_	_	_	_	_
268	of	_	_	_	_	_	_	_	_
269	TNF	_	_	_	_	_	_	_	_
270	-	_	_	_	_	_	_	_	_
271	a	_	_	_	_	_	_	_	_
272	,	_	_	_	_	_	_	_	_
273	TLR-3	_	_	_	_	_	_	_	_
274	and	_	_	_	_	_	_	_	_
275	IL-6	_	_	_	_	_	_	_	_
276	were	_	_	_	_	_	_	_	_
277	decreased	_	_	_	_	_	_	_	_
278	in	_	_	_	_	_	_	_	_
279	the	_	_	_	_	_	_	_	_
280	SwIV	_	_	_	_	_	_	_	_
281	-	_	_	_	_	_	_	_	_
282	infected	_	_	_	_	_	_	_	_
283	and	_	_	_	_	_	_	_	_
284	probiotic	_	_	_	_	_	_	_	_
285	treated	_	_	_	_	_	_	_	_
286	cells	_	_	_	_	_	_	_	_
287	,	_	_	_	_	_	_	_	_
288	IL-10	_	_	_	_	_	_	_	BeginSeg=Yes
289	was	_	_	_	_	_	_	_	_
290	found	_	_	_	_	_	_	_	_
291	to	_	_	_	_	_	_	_	_
292	be	_	_	_	_	_	_	_	_
293	increased	_	_	_	_	_	_	_	_
294	.	_	_	_	_	_	_	_	_
295	Since	_	_	_	_	_	_	_	BeginSeg=Yes
296	we	_	_	_	_	_	_	_	_
297	obtained	_	_	_	_	_	_	_	_
298	experimental	_	_	_	_	_	_	_	_
299	evidence	_	_	_	_	_	_	_	_
300	for	_	_	_	_	_	_	_	_
301	the	_	_	_	_	_	_	_	_
302	direct	_	_	_	_	_	_	_	_
303	adsorptive	_	_	_	_	_	_	_	_
304	trapping	_	_	_	_	_	_	_	_
305	of	_	_	_	_	_	_	_	_
306	SwIV	_	_	_	_	_	_	_	_
307	through	_	_	_	_	_	_	_	_
308	E.	_	_	_	_	_	_	_	_
309	faecium	_	_	_	_	_	_	_	_
310	,	_	_	_	_	_	_	_	_
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312	probiotic	_	_	_	_	_	_	_	_
313	microorganism	_	_	_	_	_	_	_	_
314	inhibits	_	_	_	_	_	_	_	_
315	influenza	_	_	_	_	_	_	_	_
316	viruses	_	_	_	_	_	_	_	_
317	by	_	_	_	_	_	_	_	_
318	at	_	_	_	_	_	_	_	_
319	least	_	_	_	_	_	_	_	_
320	two	_	_	_	_	_	_	_	_
321	mechanisms	_	_	_	_	_	_	_	_
322	,	_	_	_	_	_	_	_	_
323	direct	_	_	_	_	_	_	_	_
324	physical	_	_	_	_	_	_	_	_
325	interaction	_	_	_	_	_	_	_	_
326	and	_	_	_	_	_	_	_	_
327	strengthening	_	_	_	_	_	_	_	_
328	of	_	_	_	_	_	_	_	_
329	innate	_	_	_	_	_	_	_	_
330	defence	_	_	_	_	_	_	_	_
331	at	_	_	_	_	_	_	_	_
332	the	_	_	_	_	_	_	_	_
333	cellular	_	_	_	_	_	_	_	_
334	level	_	_	_	_	_	_	_	_
335	.	_	_	_	_	_	_	_	_

# newdoc_id = 480f67bf4f825dbc367fb67ec6de5b1664299eb5
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2	highly	_	_	_	_	_	_	_	_
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4	disease	_	_	_	_	_	_	_	_
5	(	_	_	_	_	_	_	_	_
6	HID	_	_	_	_	_	_	_	_
7	)	_	_	_	_	_	_	_	_
8	that	_	_	_	_	_	_	_	BeginSeg=Yes
9	is	_	_	_	_	_	_	_	_
10	transmissible	_	_	_	_	_	_	_	_
11	from	_	_	_	_	_	_	_	_
12	person	_	_	_	_	_	_	_	_
13	to	_	_	_	_	_	_	_	_
14	person	_	_	_	_	_	_	_	_
15	causes	_	_	_	_	_	_	_	BeginSeg=Yes
16	life	_	_	_	_	_	_	_	_
17	-	_	_	_	_	_	_	_	_
18	threatening	_	_	_	_	_	_	_	_
19	illness	_	_	_	_	_	_	_	_
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21	presents	_	_	_	_	_	_	_	_
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23	serious	_	_	_	_	_	_	_	_
24	hazard	_	_	_	_	_	_	_	_
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26	the	_	_	_	_	_	_	_	_
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29	and	_	_	_	_	_	_	_	_
30	in	_	_	_	_	_	_	_	_
31	the	_	_	_	_	_	_	_	_
32	community	_	_	_	_	_	_	_	_
33	that	_	_	_	_	_	_	_	BeginSeg=Yes
34	requires	_	_	_	_	_	_	_	_
35	specific	_	_	_	_	_	_	_	_
36	control	_	_	_	_	_	_	_	_
37	measures	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
39	Due	_	_	_	_	_	_	_	BeginSeg=Yes
40	to	_	_	_	_	_	_	_	_
41	environmental	_	_	_	_	_	_	_	_
42	factors	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	changes	_	_	_	_	_	_	_	_
45	in	_	_	_	_	_	_	_	_
46	lifestyle	_	_	_	_	_	_	_	_
47	and	_	_	_	_	_	_	_	_
48	many	_	_	_	_	_	_	_	_
49	other	_	_	_	_	_	_	_	_
50	unknown	_	_	_	_	_	_	_	_
51	factors	_	_	_	_	_	_	_	_
52	,	_	_	_	_	_	_	_	_
53	the	_	_	_	_	_	_	_	BeginSeg=Yes
54	emergence	_	_	_	_	_	_	_	_
55	of	_	_	_	_	_	_	_	_
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57	HIDs	_	_	_	_	_	_	_	_
58	is	_	_	_	_	_	_	_	_
59	becoming	_	_	_	_	_	_	_	_
60	more	_	_	_	_	_	_	_	_
61	and	_	_	_	_	_	_	_	_
62	more	_	_	_	_	_	_	_	_
63	likely	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
65	As	_	_	_	_	_	_	_	BeginSeg=Yes
66	has	_	_	_	_	_	_	_	_
67	already	_	_	_	_	_	_	_	_
68	been	_	_	_	_	_	_	_	_
69	demonstrated	_	_	_	_	_	_	_	_
70	during	_	_	_	_	_	_	_	_
71	the	_	_	_	_	_	_	_	_
72	SARS	_	_	_	_	_	_	_	_
73	outbreak	_	_	_	_	_	_	_	_
74	,	_	_	_	_	_	_	_	_
75	healthcare	_	_	_	_	_	_	_	BeginSeg=Yes
76	facilities	_	_	_	_	_	_	_	_
77	are	_	_	_	_	_	_	_	_
78	likely	_	_	_	_	_	_	_	_
79	to	_	_	_	_	_	_	_	_
80	be	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	origin	_	_	_	_	_	_	_	_
83	of	_	_	_	_	_	_	_	_
84	future	_	_	_	_	_	_	_	_
85	HID	_	_	_	_	_	_	_	_
86	outbreaks	_	_	_	_	_	_	_	_
87	.	_	_	_	_	_	_	_	_
88	Preparedness	_	_	_	_	_	_	_	BeginSeg=Yes
89	planning	_	_	_	_	_	_	_	_
90	will	_	_	_	_	_	_	_	_
91	be	_	_	_	_	_	_	_	_
92	essential	_	_	_	_	_	_	_	_
93	in	_	_	_	_	_	_	_	BeginSeg=Yes
94	helping	_	_	_	_	_	_	_	_
95	facilities	_	_	_	_	_	_	_	_
96	manage	_	_	_	_	_	_	_	_
97	future	_	_	_	_	_	_	_	_
98	outbreaks	_	_	_	_	_	_	_	_
99	of	_	_	_	_	_	_	_	_
100	emerging	_	_	_	_	_	_	_	_
101	or	_	_	_	_	_	_	_	_
102	resurgent	_	_	_	_	_	_	_	_
103	infectious	_	_	_	_	_	_	_	_
104	diseases	_	_	_	_	_	_	_	_
105	.	_	_	_	_	_	_	_	_
106	Guidelines	_	_	_	_	_	_	_	BeginSeg=Yes
107	have	_	_	_	_	_	_	_	_
108	been	_	_	_	_	_	_	_	_
109	developed	_	_	_	_	_	_	_	_
110	by	_	_	_	_	_	_	_	_
111	national	_	_	_	_	_	_	_	_
112	and	_	_	_	_	_	_	_	_
113	international	_	_	_	_	_	_	_	_
114	institutions	_	_	_	_	_	_	_	_
115	.	_	_	_	_	_	_	_	_
116	To	_	_	_	_	_	_	_	BeginSeg=Yes
117	avoid	_	_	_	_	_	_	_	_
118	contamination	_	_	_	_	_	_	_	_
119	of	_	_	_	_	_	_	_	_
120	healthcare	_	_	_	_	_	_	_	_
121	workers	_	_	_	_	_	_	_	_
122	,	_	_	_	_	_	_	_	_
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124	care	_	_	_	_	_	_	_	_
125	of	_	_	_	_	_	_	_	_
126	HID	_	_	_	_	_	_	_	_
127	patients	_	_	_	_	_	_	_	_
128	should	_	_	_	_	_	_	_	_
129	follow	_	_	_	_	_	_	_	_
130	the	_	_	_	_	_	_	_	_
131	same	_	_	_	_	_	_	_	_
132	infection	_	_	_	_	_	_	_	_
133	control	_	_	_	_	_	_	_	_
134	rules	_	_	_	_	_	_	_	_
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137	applied	_	_	_	_	_	_	_	_
138	to	_	_	_	_	_	_	_	_
139	laboratory	_	_	_	_	_	_	_	_
140	workers	_	_	_	_	_	_	_	_
141	exposed	_	_	_	_	_	_	_	BeginSeg=Yes
142	to	_	_	_	_	_	_	_	_
143	similar	_	_	_	_	_	_	_	_
144	agents	_	_	_	_	_	_	_	_
145	.	_	_	_	_	_	_	_	_
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152	the	_	_	_	_	_	_	_	_
153	clinical	_	_	_	_	_	_	_	_
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160	reviewed	_	_	_	_	_	_	_	_
161	,	_	_	_	_	_	_	_	_
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163	specific	_	_	_	_	_	_	_	_
164	aspects	_	_	_	_	_	_	_	_
165	of	_	_	_	_	_	_	_	_
166	the	_	_	_	_	_	_	_	_
167	management	_	_	_	_	_	_	_	_
168	of	_	_	_	_	_	_	_	_
169	such	_	_	_	_	_	_	_	_
170	diseases	_	_	_	_	_	_	_	_
171	are	_	_	_	_	_	_	_	_
172	introduced	_	_	_	_	_	_	_	_
173	.	_	_	_	_	_	_	_	_

# newdoc_id = 48522c9977177ec26e13ed9809b541d614b78160
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2	outbreak	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
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6	at	_	_	_	_	_	_	_	_
7	Wuhan	_	_	_	_	_	_	_	_
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9	China	_	_	_	_	_	_	_	_
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26	whole	_	_	_	_	_	_	_	_
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31	-	_	_	_	_	_	_	_	_
32	CoV-2	_	_	_	_	_	_	_	_
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50	spp	_	_	_	_	_	_	_	_
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57	.	_	_	_	_	_	_	_	_
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81	also	_	_	_	_	_	_	_	_
82	performed	_	_	_	_	_	_	_	_
83	functional	_	_	_	_	_	_	_	_
84	overrepresentation	_	_	_	_	_	_	_	_
85	analysis	_	_	_	_	_	_	_	_
86	of	_	_	_	_	_	_	_	_
87	interacting	_	_	_	_	_	_	_	_
88	proteins	_	_	_	_	_	_	_	_
89	to	_	_	_	_	_	_	_	BeginSeg=Yes
90	understand	_	_	_	_	_	_	_	_
91	their	_	_	_	_	_	_	_	_
92	role	_	_	_	_	_	_	_	_
93	in	_	_	_	_	_	_	_	_
94	COVID-2019	_	_	_	_	_	_	_	_
95	severity	_	_	_	_	_	_	_	_
96	.	_	_	_	_	_	_	_	_
97	Results	_	_	_	_	_	_	_	BeginSeg=Yes
98	:	_	_	_	_	_	_	_	_
99	It	_	_	_	_	_	_	_	BeginSeg=Yes
100	was	_	_	_	_	_	_	_	_
101	found	_	_	_	_	_	_	_	_
102	that	_	_	_	_	_	_	_	_
103	over	_	_	_	_	_	_	_	_
104	-	_	_	_	_	_	_	_	_
105	expressed	_	_	_	_	_	_	_	_
106	Prevotella	_	_	_	_	_	_	_	_
107	proteins	_	_	_	_	_	_	_	_
108	can	_	_	_	_	_	_	_	_
109	promote	_	_	_	_	_	_	_	_
110	viral	_	_	_	_	_	_	_	_
111	infection	_	_	_	_	_	_	_	_
112	.	_	_	_	_	_	_	_	_
113	As	_	_	_	_	_	_	_	BeginSeg=Yes
114	per	_	_	_	_	_	_	_	_
115	the	_	_	_	_	_	_	_	_
116	results	_	_	_	_	_	_	_	_
117	,	_	_	_	_	_	_	_	_
118	Prevotella	_	_	_	_	_	_	_	_
119	proteins	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	but	_	_	_	_	_	_	_	_
122	not	_	_	_	_	_	_	_	_
123	viral	_	_	_	_	_	_	_	_
124	proteins	_	_	_	_	_	_	_	_
125	are	_	_	_	_	_	_	_	_
126	involved	_	_	_	_	_	_	_	_
127	in	_	_	_	_	_	_	_	_
128	multiple	_	_	_	_	_	_	_	_
129	interactions	_	_	_	_	_	_	_	_
130	with	_	_	_	_	_	_	_	_
131	NF	_	_	_	_	_	_	_	_
132	-	_	_	_	_	_	_	_	_
133	kB	_	_	_	_	_	_	_	_
134	,	_	_	_	_	_	_	_	_
135	which	_	_	_	_	_	_	_	BeginSeg=Yes
136	is	_	_	_	_	_	_	_	_
137	involved	_	_	_	_	_	_	_	_
138	in	_	_	_	_	_	_	_	_
139	increasing	_	_	_	_	_	_	_	_
140	clinical	_	_	_	_	_	_	_	_
141	severity	_	_	_	_	_	_	_	_
142	of	_	_	_	_	_	_	_	_
143	COVID-2019	_	_	_	_	_	_	_	_
144	.	_	_	_	_	_	_	_	_
145	Prevotella	_	_	_	_	_	_	_	BeginSeg=Yes
146	may	_	_	_	_	_	_	_	_
147	have	_	_	_	_	_	_	_	_
148	role	_	_	_	_	_	_	_	_
149	in	_	_	_	_	_	_	_	_
150	COVID-2019	_	_	_	_	_	_	_	_
151	outbreak	_	_	_	_	_	_	_	_
152	and	_	_	_	_	_	_	_	BeginSeg=Yes
153	should	_	_	_	_	_	_	_	_
154	be	_	_	_	_	_	_	_	_
155	given	_	_	_	_	_	_	_	_
156	importance	_	_	_	_	_	_	_	_
157	for	_	_	_	_	_	_	_	BeginSeg=Yes
158	understanding	_	_	_	_	_	_	_	_
159	disease	_	_	_	_	_	_	_	_
160	mechanisms	_	_	_	_	_	_	_	_
161	and	_	_	_	_	_	_	_	BeginSeg=Yes
162	improving	_	_	_	_	_	_	_	_
163	treatment	_	_	_	_	_	_	_	_
164	outcomes	_	_	_	_	_	_	_	_
165	.	_	_	_	_	_	_	_	_

# newdoc_id = 4a7a1d6fa1a47905fb52c387ace37f8bca5fae42
1	Background	_	_	_	_	_	_	_	BeginSeg=Yes
2	:	_	_	_	_	_	_	_	_
3	Hospitalized	_	_	_	_	_	_	_	BeginSeg=Yes
4	bronchiolitis	_	_	_	_	_	_	_	_
5	imposes	_	_	_	_	_	_	_	_
6	a	_	_	_	_	_	_	_	_
7	significant	_	_	_	_	_	_	_	_
8	burden	_	_	_	_	_	_	_	_
9	among	_	_	_	_	_	_	_	_
10	infants	_	_	_	_	_	_	_	_
11	,	_	_	_	_	_	_	_	_
12	particularly	_	_	_	_	_	_	_	_
13	among	_	_	_	_	_	_	_	_
14	Indigenous	_	_	_	_	_	_	_	_
15	children	_	_	_	_	_	_	_	_
16	.	_	_	_	_	_	_	_	_
17	Traditional	_	_	_	_	_	_	_	BeginSeg=Yes
18	or	_	_	_	_	_	_	_	_
19	known	_	_	_	_	_	_	_	_
20	risk	_	_	_	_	_	_	_	_
21	factors	_	_	_	_	_	_	_	_
22	for	_	_	_	_	_	_	_	_
23	severe	_	_	_	_	_	_	_	_
24	disease	_	_	_	_	_	_	_	_
25	are	_	_	_	_	_	_	_	_
26	well	_	_	_	_	_	_	_	_
27	described	_	_	_	_	_	_	_	_
28	,	_	_	_	_	_	_	_	_
29	but	_	_	_	_	_	_	_	BeginSeg=Yes
30	there	_	_	_	_	_	_	_	_
31	are	_	_	_	_	_	_	_	_
32	limited	_	_	_	_	_	_	_	_
33	data	_	_	_	_	_	_	_	_
34	on	_	_	_	_	_	_	_	_
35	risks	_	_	_	_	_	_	_	_
36	for	_	_	_	_	_	_	_	_
37	prolonged	_	_	_	_	_	_	_	_
38	hospitalization	_	_	_	_	_	_	_	_
39	and	_	_	_	_	_	_	_	_
40	persistent	_	_	_	_	_	_	_	_
41	symptoms	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
43	Our	_	_	_	_	_	_	_	BeginSeg=Yes
44	aims	_	_	_	_	_	_	_	_
45	were	_	_	_	_	_	_	_	_
46	to	_	_	_	_	_	_	_	_
47	determine	_	_	_	_	_	_	_	_
48	factors	_	_	_	_	_	_	_	_
49	(	_	_	_	_	_	_	_	_
50	clinical	_	_	_	_	_	_	_	_
51	and	_	_	_	_	_	_	_	_
52	microbiological	_	_	_	_	_	_	_	_
53	)	_	_	_	_	_	_	_	_
54	associated	_	_	_	_	_	_	_	_
55	with	_	_	_	_	_	_	_	_
56	(	_	_	_	_	_	_	_	_
57	i	_	_	_	_	_	_	_	_
58	)	_	_	_	_	_	_	_	_
59	prolonged	_	_	_	_	_	_	_	_
60	length	_	_	_	_	_	_	_	_
61	of	_	_	_	_	_	_	_	_
62	stay	_	_	_	_	_	_	_	_
63	(	_	_	_	_	_	_	_	_
64	LOS	_	_	_	_	_	_	_	_
65	)	_	_	_	_	_	_	_	_
66	;	_	_	_	_	_	_	_	_
67	(	_	_	_	_	_	_	_	_
68	ii	_	_	_	_	_	_	_	_
69	)	_	_	_	_	_	_	_	_
70	persistent	_	_	_	_	_	_	_	_
71	respiratory	_	_	_	_	_	_	_	_
72	symptoms	_	_	_	_	_	_	_	_
73	at	_	_	_	_	_	_	_	_
74	3	_	_	_	_	_	_	_	_
75	weeks	_	_	_	_	_	_	_	_
76	;	_	_	_	_	_	_	_	_
77	(	_	_	_	_	_	_	_	_
78	iii	_	_	_	_	_	_	_	_
79	)	_	_	_	_	_	_	_	_
80	bronchiectasis	_	_	_	_	_	_	_	_
81	up	_	_	_	_	_	_	_	_
82	to	_	_	_	_	_	_	_	_
83	$	_	_	_	_	_	_	_	_
84	24	_	_	_	_	_	_	_	_
85	months	_	_	_	_	_	_	_	_
86	post	_	_	_	_	_	_	_	_
87	-	_	_	_	_	_	_	_	_
88	hospitalisation	_	_	_	_	_	_	_	_
89	;	_	_	_	_	_	_	_	_
90	and	_	_	_	_	_	_	_	_
91	(	_	_	_	_	_	_	_	_
92	iv	_	_	_	_	_	_	_	_
93	)	_	_	_	_	_	_	_	_
94	risk	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	respiratory	_	_	_	_	_	_	_	_
97	readmissions	_	_	_	_	_	_	_	_
98	within	_	_	_	_	_	_	_	_
99	6	_	_	_	_	_	_	_	_
100	months	_	_	_	_	_	_	_	_
101	.	_	_	_	_	_	_	_	_
102	Methods	_	_	_	_	_	_	_	BeginSeg=Yes
103	:	_	_	_	_	_	_	_	_
104	Indigenous	_	_	_	_	_	_	_	BeginSeg=Yes
105	infants	_	_	_	_	_	_	_	_
106	hospitalized	_	_	_	_	_	_	_	BeginSeg=Yes
107	with	_	_	_	_	_	_	_	_
108	bronchiolitis	_	_	_	_	_	_	_	_
109	were	_	_	_	_	_	_	_	BeginSeg=Yes
110	enrolled	_	_	_	_	_	_	_	_
111	at	_	_	_	_	_	_	_	_
112	Royal	_	_	_	_	_	_	_	_
113	Darwin	_	_	_	_	_	_	_	_
114	Hospital	_	_	_	_	_	_	_	_
115	between	_	_	_	_	_	_	_	_
116	2008	_	_	_	_	_	_	_	_
117	and	_	_	_	_	_	_	_	_
118	2013	_	_	_	_	_	_	_	_
119	.	_	_	_	_	_	_	_	_
120	Standardized	_	_	_	_	_	_	_	BeginSeg=Yes
121	forms	_	_	_	_	_	_	_	_
122	were	_	_	_	_	_	_	_	_
123	used	_	_	_	_	_	_	_	_
124	to	_	_	_	_	_	_	_	BeginSeg=Yes
125	record	_	_	_	_	_	_	_	_
126	clinical	_	_	_	_	_	_	_	_
127	data	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	A	_	_	_	_	_	_	_	BeginSeg=Yes
130	nasopharyngeal	_	_	_	_	_	_	_	_
131	swab	_	_	_	_	_	_	_	_
132	was	_	_	_	_	_	_	_	_
133	collected	_	_	_	_	_	_	_	_
134	at	_	_	_	_	_	_	_	_
135	enrolment	_	_	_	_	_	_	_	_
136	to	_	_	_	_	_	_	_	BeginSeg=Yes
137	identify	_	_	_	_	_	_	_	_
138	respiratory	_	_	_	_	_	_	_	_
139	viruses	_	_	_	_	_	_	_	_
140	and	_	_	_	_	_	_	_	_
141	bacteria	_	_	_	_	_	_	_	_
142	.	_	_	_	_	_	_	_	_
143	Results	_	_	_	_	_	_	_	BeginSeg=Yes
144	:	_	_	_	_	_	_	_	_
145	The	_	_	_	_	_	_	_	BeginSeg=Yes
146	median	_	_	_	_	_	_	_	_
147	age	_	_	_	_	_	_	_	_
148	of	_	_	_	_	_	_	_	_
149	232	_	_	_	_	_	_	_	_
150	infants	_	_	_	_	_	_	_	_
151	was	_	_	_	_	_	_	_	_
152	5	_	_	_	_	_	_	_	_
153	months	_	_	_	_	_	_	_	_
154	(	_	_	_	_	_	_	_	BeginSeg=Yes
155	interquartile	_	_	_	_	_	_	_	_
156	range	_	_	_	_	_	_	_	_
157	3	_	_	_	_	_	_	_	_
158	-	_	_	_	_	_	_	_	_
159	9	_	_	_	_	_	_	_	_
160	)	_	_	_	_	_	_	_	_
161	;	_	_	_	_	_	_	_	_
162	65	_	_	_	_	_	_	_	BeginSeg=Yes
163	%	_	_	_	_	_	_	_	_
164	male	_	_	_	_	_	_	_	_
165	.	_	_	_	_	_	_	_	_
166	On	_	_	_	_	_	_	_	BeginSeg=Yes
167	multivariate	_	_	_	_	_	_	_	_
168	regression	_	_	_	_	_	_	_	_
169	,	_	_	_	_	_	_	_	_
170	our	_	_	_	_	_	_	_	_
171	12	_	_	_	_	_	_	_	_
172	point	_	_	_	_	_	_	_	_
173	severity	_	_	_	_	_	_	_	_
174	score	_	_	_	_	_	_	_	_
175	(	_	_	_	_	_	_	_	BeginSeg=Yes
176	including	_	_	_	_	_	_	_	_
177	accessory	_	_	_	_	_	_	_	_
178	muscle	_	_	_	_	_	_	_	_
179	use	_	_	_	_	_	_	_	_
180	)	_	_	_	_	_	_	_	_
181	was	_	_	_	_	_	_	_	BeginSeg=Yes
182	the	_	_	_	_	_	_	_	_
183	only	_	_	_	_	_	_	_	_
184	factor	_	_	_	_	_	_	_	_
185	associated	_	_	_	_	_	_	_	BeginSeg=Yes
186	with	_	_	_	_	_	_	_	_
187	prolonged	_	_	_	_	_	_	_	_
188	LOS	_	_	_	_	_	_	_	_
189	but	_	_	_	_	_	_	_	BeginSeg=Yes
190	the	_	_	_	_	_	_	_	_
191	effect	_	_	_	_	_	_	_	_
192	was	_	_	_	_	_	_	_	_
193	modest	_	_	_	_	_	_	_	_
194	(	_	_	_	_	_	_	_	BeginSeg=Yes
195	þ3.0	_	_	_	_	_	_	_	_
196	hr	_	_	_	_	_	_	_	_
197	per	_	_	_	_	_	_	_	_
198	point	_	_	_	_	_	_	_	_
199	,	_	_	_	_	_	_	_	_
200	95%CI	_	_	_	_	_	_	_	_
201	:	_	_	_	_	_	_	_	_
202	0.7	_	_	_	_	_	_	_	_
203	,	_	_	_	_	_	_	_	_
204	5.1	_	_	_	_	_	_	_	_
205	,	_	_	_	_	_	_	_	_
206	P	_	_	_	_	_	_	_	_
207	¼	_	_	_	_	_	_	_	_
208	0.01	_	_	_	_	_	_	_	_
209	)	_	_	_	_	_	_	_	_
210	.	_	_	_	_	_	_	_	_
211	Presence	_	_	_	_	_	_	_	BeginSeg=Yes
212	of	_	_	_	_	_	_	_	_
213	cough	_	_	_	_	_	_	_	_
214	at	_	_	_	_	_	_	_	_
215	3	_	_	_	_	_	_	_	_
216	weeks	_	_	_	_	_	_	_	_
217	increased	_	_	_	_	_	_	_	_
218	the	_	_	_	_	_	_	_	_
219	odds	_	_	_	_	_	_	_	_
220	of	_	_	_	_	_	_	_	_
221	bronchiectasis	_	_	_	_	_	_	_	_
222	(	_	_	_	_	_	_	_	BeginSeg=Yes
223	OR	_	_	_	_	_	_	_	_
224	3.0	_	_	_	_	_	_	_	_
225	,	_	_	_	_	_	_	_	_
226	95%CI	_	_	_	_	_	_	_	_
227	:	_	_	_	_	_	_	_	_
228	1.1	_	_	_	_	_	_	_	_
229	,	_	_	_	_	_	_	_	_
230	7.0	_	_	_	_	_	_	_	_
231	,	_	_	_	_	_	_	_	_
232	P	_	_	_	_	_	_	_	_
233	¼	_	_	_	_	_	_	_	_
234	0.03	_	_	_	_	_	_	_	_
235	)	_	_	_	_	_	_	_	_
236	.	_	_	_	_	_	_	_	_
237	Factors	_	_	_	_	_	_	_	BeginSeg=Yes
238	associated	_	_	_	_	_	_	_	BeginSeg=Yes
239	with	_	_	_	_	_	_	_	_
240	respiratory	_	_	_	_	_	_	_	_
241	readmissions	_	_	_	_	_	_	_	_
242	were	_	_	_	_	_	_	_	BeginSeg=Yes
243	:	_	_	_	_	_	_	_	_
244	previous	_	_	_	_	_	_	_	_
245	respiratory	_	_	_	_	_	_	_	_
246	hospitalization	_	_	_	_	_	_	_	_
247	(	_	_	_	_	_	_	_	BeginSeg=Yes
248	OR	_	_	_	_	_	_	_	_
249	2.3	_	_	_	_	_	_	_	_
250	,	_	_	_	_	_	_	_	_
251	95%CI	_	_	_	_	_	_	_	_
252	:	_	_	_	_	_	_	_	_
253	1.0	_	_	_	_	_	_	_	_
254	,	_	_	_	_	_	_	_	_
255	5.4	_	_	_	_	_	_	_	_
256	,	_	_	_	_	_	_	_	_
257	P	_	_	_	_	_	_	_	_
258	¼	_	_	_	_	_	_	_	_
259	0.05	_	_	_	_	_	_	_	_
260	)	_	_	_	_	_	_	_	_
261	and	_	_	_	_	_	_	_	BeginSeg=Yes
262	household	_	_	_	_	_	_	_	_
263	smoke	_	_	_	_	_	_	_	_
264	(	_	_	_	_	_	_	_	BeginSeg=Yes
265	OR	_	_	_	_	_	_	_	_
266	2.6	_	_	_	_	_	_	_	_
267	,	_	_	_	_	_	_	_	_
268	95%CI	_	_	_	_	_	_	_	_
269	:	_	_	_	_	_	_	_	_
270	1.0	_	_	_	_	_	_	_	_
271	,	_	_	_	_	_	_	_	_
272	6.3	_	_	_	_	_	_	_	_
273	,	_	_	_	_	_	_	_	_
274	P	_	_	_	_	_	_	_	_
275	¼	_	_	_	_	_	_	_	_
276	0.04	_	_	_	_	_	_	_	_
277	)	_	_	_	_	_	_	_	_
278	.	_	_	_	_	_	_	_	_
279	Conclusion	_	_	_	_	_	_	_	BeginSeg=Yes
280	:	_	_	_	_	_	_	_	_
281	Increased	_	_	_	_	_	_	_	BeginSeg=Yes
282	severity	_	_	_	_	_	_	_	_
283	score	_	_	_	_	_	_	_	_
284	is	_	_	_	_	_	_	_	_
285	associated	_	_	_	_	_	_	_	_
286	with	_	_	_	_	_	_	_	_
287	prolonged	_	_	_	_	_	_	_	_
288	LOS	_	_	_	_	_	_	_	_
289	in	_	_	_	_	_	_	_	_
290	Indigenous	_	_	_	_	_	_	_	_
291	children	_	_	_	_	_	_	_	_
292	hospitalized	_	_	_	_	_	_	_	BeginSeg=Yes
293	with	_	_	_	_	_	_	_	_
294	bronchiolitis	_	_	_	_	_	_	_	_
295	.	_	_	_	_	_	_	_	_
296	As	_	_	_	_	_	_	_	BeginSeg=Yes
297	persistent	_	_	_	_	_	_	_	_
298	symptoms	_	_	_	_	_	_	_	_
299	at	_	_	_	_	_	_	_	_
300	3	_	_	_	_	_	_	_	_
301	weeks	_	_	_	_	_	_	_	_
302	post	_	_	_	_	_	_	_	_
303	-	_	_	_	_	_	_	_	_
304	hospitalization	_	_	_	_	_	_	_	_
305	are	_	_	_	_	_	_	_	_
306	associated	_	_	_	_	_	_	_	_
307	with	_	_	_	_	_	_	_	_
308	future	_	_	_	_	_	_	_	_
309	diagnosis	_	_	_	_	_	_	_	_
310	of	_	_	_	_	_	_	_	_
311	bronchiectasis	_	_	_	_	_	_	_	_
312	,	_	_	_	_	_	_	_	_
313	optimising	_	_	_	_	_	_	_	BeginSeg=Yes
314	clinical	_	_	_	_	_	_	_	_
315	care	_	_	_	_	_	_	_	_
316	beyond	_	_	_	_	_	_	_	_
317	hospitalization	_	_	_	_	_	_	_	_
318	is	_	_	_	_	_	_	_	_
319	needed	_	_	_	_	_	_	_	_
320	to	_	_	_	_	_	_	_	BeginSeg=Yes
321	improve	_	_	_	_	_	_	_	_
322	long	_	_	_	_	_	_	_	_
323	-	_	_	_	_	_	_	_	_
324	term	_	_	_	_	_	_	_	_
325	respiratory	_	_	_	_	_	_	_	_
326	outcomes	_	_	_	_	_	_	_	_
327	for	_	_	_	_	_	_	_	_
328	infants	_	_	_	_	_	_	_	_
329	at	_	_	_	_	_	_	_	_
330	risk	_	_	_	_	_	_	_	_
331	of	_	_	_	_	_	_	_	_
332	respiratory	_	_	_	_	_	_	_	_
333	disease	_	_	_	_	_	_	_	_
334	.	_	_	_	_	_	_	_	_

# newdoc_id = 4db77ad7a1c0aaa52615c22c0f58e9b2ddd96a02
1	Coronavirus	_	_	_	_	_	_	_	BeginSeg=Yes
2	epidemic	_	_	_	_	_	_	_	_
3	caused	_	_	_	_	_	_	_	_
4	announcing	_	_	_	_	_	_	_	_
5	emergency	_	_	_	_	_	_	_	_
6	case	_	_	_	_	_	_	_	_
7	in	_	_	_	_	_	_	_	_
8	South	_	_	_	_	_	_	_	_
9	Korea	_	_	_	_	_	_	_	_
10	.	_	_	_	_	_	_	_	_
11	The	_	_	_	_	_	_	_	BeginSeg=Yes
12	virus	_	_	_	_	_	_	_	_
13	started	_	_	_	_	_	_	_	_
14	with	_	_	_	_	_	_	_	_
15	one	_	_	_	_	_	_	_	_
16	infected	_	_	_	_	_	_	_	_
17	case	_	_	_	_	_	_	_	_
18	by	_	_	_	_	_	_	_	_
19	January	_	_	_	_	_	_	_	_
20	20	_	_	_	_	_	_	_	_
21	,	_	_	_	_	_	_	_	_
22	2020	_	_	_	_	_	_	_	_
23	,	_	_	_	_	_	_	_	_
24	where	_	_	_	_	_	_	_	BeginSeg=Yes
25	9583	_	_	_	_	_	_	_	_
26	announced	_	_	_	_	_	_	_	_
27	cases	_	_	_	_	_	_	_	_
28	were	_	_	_	_	_	_	_	_
29	reported	_	_	_	_	_	_	_	_
30	by	_	_	_	_	_	_	_	_
31	March	_	_	_	_	_	_	_	_
32	29	_	_	_	_	_	_	_	_
33	,	_	_	_	_	_	_	_	_
34	2020	_	_	_	_	_	_	_	_
35	.	_	_	_	_	_	_	_	_
36	This	_	_	_	_	_	_	_	BeginSeg=Yes
37	indicates	_	_	_	_	_	_	_	_
38	that	_	_	_	_	_	_	_	BeginSeg=Yes
39	the	_	_	_	_	_	_	_	_
40	number	_	_	_	_	_	_	_	_
41	of	_	_	_	_	_	_	_	_
42	confirmed	_	_	_	_	_	_	_	_
43	cases	_	_	_	_	_	_	_	_
44	is	_	_	_	_	_	_	_	_
45	increasing	_	_	_	_	_	_	_	_
46	rapidly	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	which	_	_	_	_	_	_	_	BeginSeg=Yes
49	can	_	_	_	_	_	_	_	_
50	cause	_	_	_	_	_	_	_	_
51	national	_	_	_	_	_	_	_	_
52	crises	_	_	_	_	_	_	_	_
53	for	_	_	_	_	_	_	_	_
54	South	_	_	_	_	_	_	_	_
55	Korea	_	_	_	_	_	_	_	_
56	.	_	_	_	_	_	_	_	_
57	The	_	_	_	_	_	_	_	BeginSeg=Yes
58	aim	_	_	_	_	_	_	_	_
59	of	_	_	_	_	_	_	_	_
60	this	_	_	_	_	_	_	_	_
61	study	_	_	_	_	_	_	_	_
62	is	_	_	_	_	_	_	_	_
63	to	_	_	_	_	_	_	_	_
64	fill	_	_	_	_	_	_	_	_
65	a	_	_	_	_	_	_	_	_
66	gap	_	_	_	_	_	_	_	_
67	between	_	_	_	_	_	_	_	_
68	previous	_	_	_	_	_	_	_	_
69	studies	_	_	_	_	_	_	_	_
70	and	_	_	_	_	_	_	_	_
71	the	_	_	_	_	_	_	_	_
72	current	_	_	_	_	_	_	_	_
73	development	_	_	_	_	_	_	_	_
74	of	_	_	_	_	_	_	_	_
75	CoVID-19	_	_	_	_	_	_	_	_
76	spreading	_	_	_	_	_	_	_	_
77	,	_	_	_	_	_	_	_	_
78	by	_	_	_	_	_	_	_	BeginSeg=Yes
79	extracting	_	_	_	_	_	_	_	_
80	a	_	_	_	_	_	_	_	_
81	relationship	_	_	_	_	_	_	_	_
82	between	_	_	_	_	_	_	_	_
83	independent	_	_	_	_	_	_	_	_
84	variables	_	_	_	_	_	_	_	_
85	and	_	_	_	_	_	_	_	_
86	dependent	_	_	_	_	_	_	_	_
87	variable	_	_	_	_	_	_	_	_
88	.	_	_	_	_	_	_	_	_
89	This	_	_	_	_	_	_	_	BeginSeg=Yes
90	research	_	_	_	_	_	_	_	_
91	statistically	_	_	_	_	_	_	_	_
92	analyzed	_	_	_	_	_	_	_	_
93	the	_	_	_	_	_	_	_	_
94	effect	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	sex	_	_	_	_	_	_	_	_
97	,	_	_	_	_	_	_	_	_
98	region	_	_	_	_	_	_	_	_
99	,	_	_	_	_	_	_	_	_
100	infection	_	_	_	_	_	_	_	_
101	reasons	_	_	_	_	_	_	_	_
102	,	_	_	_	_	_	_	_	_
103	birth	_	_	_	_	_	_	_	_
104	year	_	_	_	_	_	_	_	_
105	,	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	released	_	_	_	_	_	_	_	_
108	or	_	_	_	_	_	_	_	_
109	diseased	_	_	_	_	_	_	_	_
110	date	_	_	_	_	_	_	_	_
111	on	_	_	_	_	_	_	_	_
112	the	_	_	_	_	_	_	_	_
113	reported	_	_	_	_	_	_	_	_
114	numbers	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	recovered	_	_	_	_	_	_	_	_
117	and	_	_	_	_	_	_	_	_
118	deceased	_	_	_	_	_	_	_	_
119	cases	_	_	_	_	_	_	_	_
120	.	_	_	_	_	_	_	_	_
121	The	_	_	_	_	_	_	_	BeginSeg=Yes
122	results	_	_	_	_	_	_	_	_
123	found	_	_	_	_	_	_	_	_
124	that	_	_	_	_	_	_	_	BeginSeg=Yes
125	sex	_	_	_	_	_	_	_	_
126	,	_	_	_	_	_	_	_	_
127	region	_	_	_	_	_	_	_	_
128	,	_	_	_	_	_	_	_	_
129	and	_	_	_	_	_	_	_	_
130	infection	_	_	_	_	_	_	_	_
131	reasons	_	_	_	_	_	_	_	_
132	affected	_	_	_	_	_	_	_	_
133	on	_	_	_	_	_	_	_	_
134	both	_	_	_	_	_	_	_	_
135	recovered	_	_	_	_	_	_	_	_
136	and	_	_	_	_	_	_	_	_
137	deceased	_	_	_	_	_	_	_	_
138	cases	_	_	_	_	_	_	_	_
139	,	_	_	_	_	_	_	_	_
140	while	_	_	_	_	_	_	_	BeginSeg=Yes
141	birth	_	_	_	_	_	_	_	_
142	year	_	_	_	_	_	_	_	_
143	only	_	_	_	_	_	_	_	_
144	affected	_	_	_	_	_	_	_	_
145	on	_	_	_	_	_	_	_	_
146	deceased	_	_	_	_	_	_	_	_
147	cases	_	_	_	_	_	_	_	_
148	.	_	_	_	_	_	_	_	_
149	Besides	_	_	_	_	_	_	_	BeginSeg=Yes
150	,	_	_	_	_	_	_	_	_
151	no	_	_	_	_	_	_	_	_
152	deceased	_	_	_	_	_	_	_	_
153	cases	_	_	_	_	_	_	_	_
154	are	_	_	_	_	_	_	_	_
155	reported	_	_	_	_	_	_	_	_
156	for	_	_	_	_	_	_	_	_
157	released	_	_	_	_	_	_	_	_
158	cases	_	_	_	_	_	_	_	_
159	,	_	_	_	_	_	_	_	_
160	while	_	_	_	_	_	_	_	BeginSeg=Yes
161	11.3	_	_	_	_	_	_	_	_
162	%	_	_	_	_	_	_	_	_
163	of	_	_	_	_	_	_	_	_
164	deceased	_	_	_	_	_	_	_	_
165	cases	_	_	_	_	_	_	_	_
166	positive	_	_	_	_	_	_	_	_
167	confirmed	_	_	_	_	_	_	_	_
168	after	_	_	_	_	_	_	_	_
169	their	_	_	_	_	_	_	_	_
170	deceased	_	_	_	_	_	_	_	_
171	.	_	_	_	_	_	_	_	_
172	Unknown	_	_	_	_	_	_	_	BeginSeg=Yes
173	reason	_	_	_	_	_	_	_	_
174	of	_	_	_	_	_	_	_	_
175	infection	_	_	_	_	_	_	_	_
176	is	_	_	_	_	_	_	_	_
177	the	_	_	_	_	_	_	_	_
178	main	_	_	_	_	_	_	_	_
179	variable	_	_	_	_	_	_	_	_
180	that	_	_	_	_	_	_	_	BeginSeg=Yes
181	detected	_	_	_	_	_	_	_	_
182	in	_	_	_	_	_	_	_	_
183	South	_	_	_	_	_	_	_	_
184	Korea	_	_	_	_	_	_	_	_
185	with	_	_	_	_	_	_	_	_
186	more	_	_	_	_	_	_	_	_
187	than	_	_	_	_	_	_	_	_
188	33	_	_	_	_	_	_	_	_
189	%	_	_	_	_	_	_	_	_
190	of	_	_	_	_	_	_	_	_
191	total	_	_	_	_	_	_	_	_
192	infected	_	_	_	_	_	_	_	_
193	cases	_	_	_	_	_	_	_	_
194	.	_	_	_	_	_	_	_	_

# newdoc_id = 4e20e6a3d99bde2aea75bc215333524538fe17ef
1	Respiratory	_	_	_	_	_	_	_	BeginSeg=Yes
2	infections	_	_	_	_	_	_	_	_
3	are	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	most	_	_	_	_	_	_	_	_
6	frequent	_	_	_	_	_	_	_	_
7	reason	_	_	_	_	_	_	_	_
8	for	_	_	_	_	_	_	_	_
9	primary	_	_	_	_	_	_	_	_
10	health	_	_	_	_	_	_	_	_
11	care	_	_	_	_	_	_	_	_
12	consultation	_	_	_	_	_	_	_	_
13	.	_	_	_	_	_	_	_	_
14	The	_	_	_	_	_	_	_	BeginSeg=Yes
15	main	_	_	_	_	_	_	_	_
16	causes	_	_	_	_	_	_	_	_
17	of	_	_	_	_	_	_	_	_
18	respiratory	_	_	_	_	_	_	_	_
19	tract	_	_	_	_	_	_	_	_
20	infections	_	_	_	_	_	_	_	_
21	in	_	_	_	_	_	_	_	_
22	children	_	_	_	_	_	_	_	_
23	are	_	_	_	_	_	_	_	_
24	viruses	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	BeginSeg=Yes
26	the	_	_	_	_	_	_	_	_
27	most	_	_	_	_	_	_	_	_
28	common	_	_	_	_	_	_	_	_
29	types	_	_	_	_	_	_	_	_
30	are	_	_	_	_	_	_	_	_
31	upper	_	_	_	_	_	_	_	_
32	respiratory	_	_	_	_	_	_	_	_
33	tract	_	_	_	_	_	_	_	_
34	infections	_	_	_	_	_	_	_	_
35	:	_	_	_	_	_	_	_	_
36	common	_	_	_	_	_	_	_	BeginSeg=Yes
37	cold	_	_	_	_	_	_	_	_
38	,	_	_	_	_	_	_	_	_
39	pharyngitis	_	_	_	_	_	_	_	_
40	,	_	_	_	_	_	_	_	_
41	otitis	_	_	_	_	_	_	_	_
42	media	_	_	_	_	_	_	_	_
43	and	_	_	_	_	_	_	_	_
44	sinusitis	_	_	_	_	_	_	_	_
45	.	_	_	_	_	_	_	_	_
46	Pneumonia	_	_	_	_	_	_	_	BeginSeg=Yes
47	is	_	_	_	_	_	_	_	_
48	much	_	_	_	_	_	_	_	_
49	more	_	_	_	_	_	_	_	_
50	serious	_	_	_	_	_	_	_	_
51	.	_	_	_	_	_	_	_	_
52	As	_	_	_	_	_	_	_	BeginSeg=Yes
53	well	_	_	_	_	_	_	_	_
54	as	_	_	_	_	_	_	_	_
55	viruses	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	bacteria	_	_	_	_	_	_	_	_
58	are	_	_	_	_	_	_	_	_
59	often	_	_	_	_	_	_	_	_
60	involved	_	_	_	_	_	_	_	_
61	in	_	_	_	_	_	_	_	_
62	respiratory	_	_	_	_	_	_	_	_
63	tract	_	_	_	_	_	_	_	_
64	infections	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
66	Three	_	_	_	_	_	_	_	BeginSeg=Yes
67	bacterial	_	_	_	_	_	_	_	_
68	species	_	_	_	_	_	_	_	_
69	are	_	_	_	_	_	_	_	_
70	most	_	_	_	_	_	_	_	_
71	commonly	_	_	_	_	_	_	_	_
72	isolated	_	_	_	_	_	_	_	_
73	:	_	_	_	_	_	_	_	_
74	Streptococcus	_	_	_	_	_	_	_	BeginSeg=Yes
75	pneumoniae	_	_	_	_	_	_	_	_
76	,	_	_	_	_	_	_	_	_
77	non	_	_	_	_	_	_	_	_
78	-	_	_	_	_	_	_	_	_
79	encapsulated	_	_	_	_	_	_	_	_
80	Haemophilus	_	_	_	_	_	_	_	_
81	influenzae	_	_	_	_	_	_	_	_
82	and	_	_	_	_	_	_	_	_
83	Moraxella	_	_	_	_	_	_	_	_
84	(	_	_	_	_	_	_	_	_
85	Branhamella	_	_	_	_	_	_	_	_
86	)	_	_	_	_	_	_	_	_
87	catarrhalis	_	_	_	_	_	_	_	_
88	.	_	_	_	_	_	_	_	_
89	The	_	_	_	_	_	_	_	BeginSeg=Yes
90	most	_	_	_	_	_	_	_	_
91	common	_	_	_	_	_	_	_	_
92	bacterial	_	_	_	_	_	_	_	_
93	cause	_	_	_	_	_	_	_	_
94	of	_	_	_	_	_	_	_	_
95	pharyngitis	_	_	_	_	_	_	_	_
96	is	_	_	_	_	_	_	_	_
97	Streptococcus	_	_	_	_	_	_	_	_
98	pyogenes	_	_	_	_	_	_	_	_
99	.	_	_	_	_	_	_	_	_
100	Bacteria	_	_	_	_	_	_	_	BeginSeg=Yes
101	isolated	_	_	_	_	_	_	_	BeginSeg=Yes
102	from	_	_	_	_	_	_	_	_
103	community	_	_	_	_	_	_	_	_
104	-	_	_	_	_	_	_	_	_
105	acquired	_	_	_	_	_	_	_	_
106	infection	_	_	_	_	_	_	_	_
107	usually	_	_	_	_	_	_	_	BeginSeg=Yes
108	are	_	_	_	_	_	_	_	_
109	sensitive	_	_	_	_	_	_	_	_
110	to	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	majority	_	_	_	_	_	_	_	_
113	of	_	_	_	_	_	_	_	_
114	suitable	_	_	_	_	_	_	_	_
115	drugs	_	_	_	_	_	_	_	_
116	,	_	_	_	_	_	_	_	_
117	but	_	_	_	_	_	_	_	BeginSeg=Yes
118	during	_	_	_	_	_	_	_	_
119	the	_	_	_	_	_	_	_	_
120	past	_	_	_	_	_	_	_	_
121	two	_	_	_	_	_	_	_	_
122	decades	_	_	_	_	_	_	_	_
123	,	_	_	_	_	_	_	_	_
124	significant	_	_	_	_	_	_	_	_
125	antibiotic	_	_	_	_	_	_	_	_
126	resistance	_	_	_	_	_	_	_	_
127	has	_	_	_	_	_	_	_	_
128	emerged	_	_	_	_	_	_	_	_
129	.	_	_	_	_	_	_	_	_
130	Resistance	_	_	_	_	_	_	_	BeginSeg=Yes
131	to	_	_	_	_	_	_	_	_
132	penicillins	_	_	_	_	_	_	_	_
133	has	_	_	_	_	_	_	_	_
134	spread	_	_	_	_	_	_	_	_
135	among	_	_	_	_	_	_	_	_
136	H.	_	_	_	_	_	_	_	_
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86	approaches	_	_	_	_	_	_	_	_
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117	plays	_	_	_	_	_	_	_	_
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119	major	_	_	_	_	_	_	_	_
120	role	_	_	_	_	_	_	_	_
121	in	_	_	_	_	_	_	_	_
122	a	_	_	_	_	_	_	_	_
123	wider	_	_	_	_	_	_	_	_
124	ongoing	_	_	_	_	_	_	_	_
125	revision	_	_	_	_	_	_	_	_
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130	viruses	_	_	_	_	_	_	_	_
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26	journals	_	_	_	_	_	_	_	_
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38	number	_	_	_	_	_	_	_	_
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40	articles	_	_	_	_	_	_	_	_
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59	phase	_	_	_	_	_	_	_	_
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61	of	_	_	_	_	_	_	_	_
62	acetonitrile	_	_	_	_	_	_	_	_
63	-	_	_	_	_	_	_	_	_
64	water	_	_	_	_	_	_	_	_
65	(	_	_	_	_	_	_	_	BeginSeg=Yes
66	containing	_	_	_	_	_	_	_	_
67	1.0	_	_	_	_	_	_	_	_
68	%	_	_	_	_	_	_	_	_
69	acetic	_	_	_	_	_	_	_	_
70	acid	_	_	_	_	_	_	_	_
71	)	_	_	_	_	_	_	_	_
72	with	_	_	_	_	_	_	_	BeginSeg=Yes
73	a	_	_	_	_	_	_	_	_
74	gradient	_	_	_	_	_	_	_	_
75	elution	_	_	_	_	_	_	_	_
76	of	_	_	_	_	_	_	_	_
77	0~10	_	_	_	_	_	_	_	_
78	min	_	_	_	_	_	_	_	_
79	from	_	_	_	_	_	_	_	_
80	20:80	_	_	_	_	_	_	_	_
81	to	_	_	_	_	_	_	_	_
82	60:40	_	_	_	_	_	_	_	_
83	(	_	_	_	_	_	_	_	_
84	v	_	_	_	_	_	_	_	_
85	/	_	_	_	_	_	_	_	_
86	v	_	_	_	_	_	_	_	_
87	)	_	_	_	_	_	_	_	_
88	.	_	_	_	_	_	_	_	_
89	Preparative	_	_	_	_	_	_	_	BeginSeg=Yes
90	columns	_	_	_	_	_	_	_	_
91	with	_	_	_	_	_	_	_	_
92	different	_	_	_	_	_	_	_	_
93	packing	_	_	_	_	_	_	_	_
94	sizes	_	_	_	_	_	_	_	_
95	were	_	_	_	_	_	_	_	_
96	investigated	_	_	_	_	_	_	_	_
97	to	_	_	_	_	_	_	_	BeginSeg=Yes
98	isolate	_	_	_	_	_	_	_	_
99	the	_	_	_	_	_	_	_	_
100	three	_	_	_	_	_	_	_	_
101	compounds	_	_	_	_	_	_	_	_
102	from	_	_	_	_	_	_	_	_
103	the	_	_	_	_	_	_	_	_
104	extracts	_	_	_	_	_	_	_	_
105	of	_	_	_	_	_	_	_	_
106	licorice	_	_	_	_	_	_	_	_
107	.	_	_	_	_	_	_	_	_
108	The	_	_	_	_	_	_	_	BeginSeg=Yes
109	12	_	_	_	_	_	_	_	_
110	μm	_	_	_	_	_	_	_	_
111	chromatographic	_	_	_	_	_	_	_	_
112	column	_	_	_	_	_	_	_	_
113	showed	_	_	_	_	_	_	_	_
114	better	_	_	_	_	_	_	_	_
115	separation	_	_	_	_	_	_	_	_
116	for	_	_	_	_	_	_	_	_
117	the	_	_	_	_	_	_	_	_
118	three	_	_	_	_	_	_	_	_
119	compounds	_	_	_	_	_	_	_	_
120	from	_	_	_	_	_	_	_	_
121	licorice	_	_	_	_	_	_	_	_
122	.	_	_	_	_	_	_	_	_
123	0.29	_	_	_	_	_	_	_	BeginSeg=Yes
124	mg	_	_	_	_	_	_	_	_
125	/	_	_	_	_	_	_	_	_
126	g	_	_	_	_	_	_	_	_
127	for	_	_	_	_	_	_	_	_
128	liquiritin	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	1.43	_	_	_	_	_	_	_	_
131	mg	_	_	_	_	_	_	_	_
132	/	_	_	_	_	_	_	_	_
133	g	_	_	_	_	_	_	_	_
134	for	_	_	_	_	_	_	_	_
135	glycyrrhizic	_	_	_	_	_	_	_	_
136	acid	_	_	_	_	_	_	_	_
137	,	_	_	_	_	_	_	_	_
138	and	_	_	_	_	_	_	_	_
139	0.07	_	_	_	_	_	_	_	_
140	mg	_	_	_	_	_	_	_	_
141	/	_	_	_	_	_	_	_	_
142	g	_	_	_	_	_	_	_	_
143	for	_	_	_	_	_	_	_	_
144	glabridin	_	_	_	_	_	_	_	_
145	were	_	_	_	_	_	_	_	_
146	obtained	_	_	_	_	_	_	_	_
147	and	_	_	_	_	_	_	_	BeginSeg=Yes
148	the	_	_	_	_	_	_	_	_
149	recoveries	_	_	_	_	_	_	_	_
150	were	_	_	_	_	_	_	_	_
151	80.8	_	_	_	_	_	_	_	_
152	,	_	_	_	_	_	_	_	_
153	89.7	_	_	_	_	_	_	_	_
154	,	_	_	_	_	_	_	_	_
155	and	_	_	_	_	_	_	_	_
156	72.5	_	_	_	_	_	_	_	_
157	%	_	_	_	_	_	_	_	_
158	,	_	_	_	_	_	_	_	_
159	respectively	_	_	_	_	_	_	_	_
160	.	_	_	_	_	_	_	_	_

# newdoc_id = 54cbb1fc4b77ae332cdb8f44a321f9db35afe2f1
1	This	_	_	_	_	_	_	_	BeginSeg=Yes
2	paper	_	_	_	_	_	_	_	_
3	highlights	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	enormous	_	_	_	_	_	_	_	_
6	economic	_	_	_	_	_	_	_	_
7	and	_	_	_	_	_	_	_	_
8	social	_	_	_	_	_	_	_	_
9	impact	_	_	_	_	_	_	_	_
10	of	_	_	_	_	_	_	_	_
11	COVID-19	_	_	_	_	_	_	_	_
12	with	_	_	_	_	_	_	_	_
13	respect	_	_	_	_	_	_	_	_
14	to	_	_	_	_	_	_	_	_
15	articles	_	_	_	_	_	_	_	_
16	that	_	_	_	_	_	_	_	BeginSeg=Yes
17	have	_	_	_	_	_	_	_	_
18	either	_	_	_	_	_	_	_	_
19	prognosticated	_	_	_	_	_	_	_	_
20	such	_	_	_	_	_	_	_	_
21	a	_	_	_	_	_	_	_	_
22	large	_	_	_	_	_	_	_	_
23	-	_	_	_	_	_	_	_	_
24	scale	_	_	_	_	_	_	_	_
25	event	_	_	_	_	_	_	_	_
26	,	_	_	_	_	_	_	_	_
27	and	_	_	_	_	_	_	_	_
28	its	_	_	_	_	_	_	_	_
29	economic	_	_	_	_	_	_	_	_
30	consequences	_	_	_	_	_	_	_	_
31	,	_	_	_	_	_	_	_	_
32	or	_	_	_	_	_	_	_	BeginSeg=Yes
33	have	_	_	_	_	_	_	_	_
34	assessed	_	_	_	_	_	_	_	_
35	the	_	_	_	_	_	_	_	_
36	impacts	_	_	_	_	_	_	_	_
37	of	_	_	_	_	_	_	_	_
38	other	_	_	_	_	_	_	_	_
39	epidemics	_	_	_	_	_	_	_	_
40	and	_	_	_	_	_	_	_	_
41	pandemics	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
43	A	_	_	_	_	_	_	_	BeginSeg=Yes
44	consideration	_	_	_	_	_	_	_	_
45	of	_	_	_	_	_	_	_	_
46	possible	_	_	_	_	_	_	_	_
47	impacts	_	_	_	_	_	_	_	_
48	of	_	_	_	_	_	_	_	_
49	COVID-19	_	_	_	_	_	_	_	_
50	on	_	_	_	_	_	_	_	_
51	financial	_	_	_	_	_	_	_	_
52	markets	_	_	_	_	_	_	_	_
53	and	_	_	_	_	_	_	_	_
54	institutions	_	_	_	_	_	_	_	_
55	,	_	_	_	_	_	_	_	_
56	either	_	_	_	_	_	_	_	_
57	directly	_	_	_	_	_	_	_	_
58	or	_	_	_	_	_	_	_	_
59	indirectly	_	_	_	_	_	_	_	_
60	,	_	_	_	_	_	_	_	_
61	is	_	_	_	_	_	_	_	_
62	briefly	_	_	_	_	_	_	_	_
63	outlined	_	_	_	_	_	_	_	_
64	by	_	_	_	_	_	_	_	BeginSeg=Yes
65	drawing	_	_	_	_	_	_	_	_
66	on	_	_	_	_	_	_	_	_
67	a	_	_	_	_	_	_	_	_
68	variety	_	_	_	_	_	_	_	_
69	of	_	_	_	_	_	_	_	_
70	literatures	_	_	_	_	_	_	_	_
71	.	_	_	_	_	_	_	_	_
72	A	_	_	_	_	_	_	_	BeginSeg=Yes
73	consideration	_	_	_	_	_	_	_	_
74	of	_	_	_	_	_	_	_	_
75	the	_	_	_	_	_	_	_	_
76	characteristics	_	_	_	_	_	_	_	_
77	of	_	_	_	_	_	_	_	_
78	COVID-19	_	_	_	_	_	_	_	_
79	,	_	_	_	_	_	_	_	_
80	along	_	_	_	_	_	_	_	_
81	with	_	_	_	_	_	_	_	_
82	what	_	_	_	_	_	_	_	_
83	research	_	_	_	_	_	_	_	_
84	suggests	_	_	_	_	_	_	_	_
85	have	_	_	_	_	_	_	_	_
86	been	_	_	_	_	_	_	_	_
87	the	_	_	_	_	_	_	_	_
88	impacts	_	_	_	_	_	_	_	_
89	of	_	_	_	_	_	_	_	_
90	other	_	_	_	_	_	_	_	_
91	past	_	_	_	_	_	_	_	_
92	events	_	_	_	_	_	_	_	_
93	that	_	_	_	_	_	_	_	BeginSeg=Yes
94	in	_	_	_	_	_	_	_	_
95	some	_	_	_	_	_	_	_	_
96	ways	_	_	_	_	_	_	_	_
97	roughly	_	_	_	_	_	_	_	_
98	parallel	_	_	_	_	_	_	_	_
99	COVID-19	_	_	_	_	_	_	_	_
100	,	_	_	_	_	_	_	_	_
101	points	_	_	_	_	_	_	_	BeginSeg=Yes
102	toward	_	_	_	_	_	_	_	_
103	avenues	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	future	_	_	_	_	_	_	_	_
106	investigation	_	_	_	_	_	_	_	_
107	.	_	_	_	_	_	_	_	_

# newdoc_id = 587118e335a8dd365f56caf0db8c2230cb9aa7cd
1	In	_	_	_	_	_	_	_	BeginSeg=Yes
2	late	_	_	_	_	_	_	_	_
3	2019	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	the	_	_	_	_	_	_	_	_
6	world	_	_	_	_	_	_	_	_
7	encountered	_	_	_	_	_	_	_	_
8	an	_	_	_	_	_	_	_	_
9	unexpected	_	_	_	_	_	_	_	_
10	new	_	_	_	_	_	_	_	_
11	virus	_	_	_	_	_	_	_	_
12	,	_	_	_	_	_	_	_	_
13	resulting	_	_	_	_	_	_	_	BeginSeg=Yes
14	in	_	_	_	_	_	_	_	_
15	a	_	_	_	_	_	_	_	_
16	highly	_	_	_	_	_	_	_	_
17	challenging	_	_	_	_	_	_	_	_
18	new	_	_	_	_	_	_	_	_
19	pandemic	_	_	_	_	_	_	_	_
20	.	_	_	_	_	_	_	_	_
21	The	_	_	_	_	_	_	_	BeginSeg=Yes
22	case	_	_	_	_	_	_	_	_
23	presented	_	_	_	_	_	_	_	BeginSeg=Yes
24	here	_	_	_	_	_	_	_	_
25	involves	_	_	_	_	_	_	_	BeginSeg=Yes
26	a	_	_	_	_	_	_	_	_
27	73-year	_	_	_	_	_	_	_	_
28	-	_	_	_	_	_	_	_	_
29	old	_	_	_	_	_	_	_	_
30	man	_	_	_	_	_	_	_	_
31	experiencing	_	_	_	_	_	_	_	BeginSeg=Yes
32	fever	_	_	_	_	_	_	_	_
33	and	_	_	_	_	_	_	_	_
34	respiratory	_	_	_	_	_	_	_	_
35	distress	_	_	_	_	_	_	_	_
36	,	_	_	_	_	_	_	_	_
37	who	_	_	_	_	_	_	_	BeginSeg=Yes
38	was	_	_	_	_	_	_	_	_
39	ultimately	_	_	_	_	_	_	_	_
40	diagnosed	_	_	_	_	_	_	_	_
41	with	_	_	_	_	_	_	_	_
42	COVID-19	_	_	_	_	_	_	_	_
43	.	_	_	_	_	_	_	_	_
44	During	_	_	_	_	_	_	_	BeginSeg=Yes
45	the	_	_	_	_	_	_	_	_
46	course	_	_	_	_	_	_	_	_
47	of	_	_	_	_	_	_	_	_
48	his	_	_	_	_	_	_	_	_
49	hospitalization	_	_	_	_	_	_	_	_
50	,	_	_	_	_	_	_	_	_
51	the	_	_	_	_	_	_	_	_
52	patient	_	_	_	_	_	_	_	_
53	developed	_	_	_	_	_	_	_	_
54	acute	_	_	_	_	_	_	_	_
55	respiratory	_	_	_	_	_	_	_	_
56	distress	_	_	_	_	_	_	_	_
57	syndrome	_	_	_	_	_	_	_	_
58	(	_	_	_	_	_	_	_	_
59	ARDS	_	_	_	_	_	_	_	_
60	)	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	followed	_	_	_	_	_	_	_	BeginSeg=Yes
63	by	_	_	_	_	_	_	_	_
64	being	_	_	_	_	_	_	_	_
65	intubated	_	_	_	_	_	_	_	_
66	due	_	_	_	_	_	_	_	BeginSeg=Yes
67	to	_	_	_	_	_	_	_	_
68	his	_	_	_	_	_	_	_	_
69	breathing	_	_	_	_	_	_	_	_
70	difficulties	_	_	_	_	_	_	_	_
71	.	_	_	_	_	_	_	_	_
72	Because	_	_	_	_	_	_	_	BeginSeg=Yes
73	of	_	_	_	_	_	_	_	_
74	variations	_	_	_	_	_	_	_	_
75	in	_	_	_	_	_	_	_	_
76	the	_	_	_	_	_	_	_	_
77-78	patient's	_	_	_	_	_	_	_	_
77	patient	_	_	_	_	_	_	_	_
78	's	_	_	_	_	_	_	_	_
79	clinical	_	_	_	_	_	_	_	_
80	features	_	_	_	_	_	_	_	_
81	,	_	_	_	_	_	_	_	_
82	we	_	_	_	_	_	_	_	BeginSeg=Yes
83	decided	_	_	_	_	_	_	_	_
84	to	_	_	_	_	_	_	_	_
85	perform	_	_	_	_	_	_	_	_
86	hemoperfusion	_	_	_	_	_	_	_	_
87	to	_	_	_	_	_	_	_	BeginSeg=Yes
88	remove	_	_	_	_	_	_	_	_
89	cytokines	_	_	_	_	_	_	_	_
90	.	_	_	_	_	_	_	_	_
91	Afterward	_	_	_	_	_	_	_	BeginSeg=Yes
92	,	_	_	_	_	_	_	_	_
93	his	_	_	_	_	_	_	_	_
94	clinical	_	_	_	_	_	_	_	_
95	status	_	_	_	_	_	_	_	_
96	improved	_	_	_	_	_	_	_	_
97	significantly	_	_	_	_	_	_	_	_
98	,	_	_	_	_	_	_	_	_
99	and	_	_	_	_	_	_	_	BeginSeg=Yes
100	he	_	_	_	_	_	_	_	_
101	was	_	_	_	_	_	_	_	_
102	discharged	_	_	_	_	_	_	_	_
103	in	_	_	_	_	_	_	_	_
104	stable	_	_	_	_	_	_	_	_
105	condition	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	However	_	_	_	_	_	_	_	BeginSeg=Yes
108	,	_	_	_	_	_	_	_	_
109	26	_	_	_	_	_	_	_	_
110	days	_	_	_	_	_	_	_	_
111	later	_	_	_	_	_	_	_	_
112	,	_	_	_	_	_	_	_	_
113	fever	_	_	_	_	_	_	_	_
114	and	_	_	_	_	_	_	_	_
115	respiratory	_	_	_	_	_	_	_	_
116	distress	_	_	_	_	_	_	_	_
117	manifested	_	_	_	_	_	_	_	_
118	again	_	_	_	_	_	_	_	_
119	.	_	_	_	_	_	_	_	_
120	After	_	_	_	_	_	_	_	BeginSeg=Yes
121	evaluation	_	_	_	_	_	_	_	_
122	,	_	_	_	_	_	_	_	_
123	pulmonary	_	_	_	_	_	_	_	_
124	thromboembolism	_	_	_	_	_	_	_	_
125	was	_	_	_	_	_	_	_	_
126	confirmed	_	_	_	_	_	_	_	_
127	through	_	_	_	_	_	_	_	_
128	computed	_	_	_	_	_	_	_	_
129	tomography	_	_	_	_	_	_	_	_
130	(	_	_	_	_	_	_	_	BeginSeg=Yes
131	ie	_	_	_	_	_	_	_	_
132	,	_	_	_	_	_	_	_	_
133	CT	_	_	_	_	_	_	_	_
134	scan	_	_	_	_	_	_	_	_
135	)	_	_	_	_	_	_	_	_
136	.	_	_	_	_	_	_	_	_

# newdoc_id = 59fe5a3ec925d965c06ea6764db86bca9fb0b8b6
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	novel	_	_	_	_	_	_	_	_
3	coronavirus	_	_	_	_	_	_	_	_
4	disease	_	_	_	_	_	_	_	_
5	2019	_	_	_	_	_	_	_	_
6	(	_	_	_	_	_	_	_	_
7	COVID-19	_	_	_	_	_	_	_	_
8	)	_	_	_	_	_	_	_	_
9	pandemic	_	_	_	_	_	_	_	_
10	is	_	_	_	_	_	_	_	_
11	a	_	_	_	_	_	_	_	_
12	major	_	_	_	_	_	_	_	_
13	global	_	_	_	_	_	_	_	_
14	threat	_	_	_	_	_	_	_	_
15	affecting	_	_	_	_	_	_	_	BeginSeg=Yes
16	millions	_	_	_	_	_	_	_	_
17	of	_	_	_	_	_	_	_	_
18	lives	_	_	_	_	_	_	_	_
19	throughout	_	_	_	_	_	_	_	_
20	the	_	_	_	_	_	_	_	_
21	world	_	_	_	_	_	_	_	_
22	physically	_	_	_	_	_	_	_	_
23	and	_	_	_	_	_	_	_	_
24	psychologically	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	With	_	_	_	_	_	_	_	BeginSeg=Yes
27	the	_	_	_	_	_	_	_	_
28	asymptomatic	_	_	_	_	_	_	_	_
29	presentation	_	_	_	_	_	_	_	_
30	of	_	_	_	_	_	_	_	_
31	COVID-19	_	_	_	_	_	_	_	_
32	in	_	_	_	_	_	_	_	_
33	many	_	_	_	_	_	_	_	_
34	patients	_	_	_	_	_	_	_	_
35	and	_	_	_	_	_	_	_	_
36	the	_	_	_	_	_	_	_	_
37	similarity	_	_	_	_	_	_	_	_
38	of	_	_	_	_	_	_	_	_
39	its	_	_	_	_	_	_	_	_
40	symptoms	_	_	_	_	_	_	_	_
41	with	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
43	common	_	_	_	_	_	_	_	_
44	cold	_	_	_	_	_	_	_	_
45	and	_	_	_	_	_	_	_	_
46	influenza	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	the	_	_	_	_	_	_	_	_
49	need	_	_	_	_	_	_	_	_
50	for	_	_	_	_	_	_	_	_
51	accurate	_	_	_	_	_	_	_	_
52	information	_	_	_	_	_	_	_	_
53	on	_	_	_	_	_	_	_	_
54	the	_	_	_	_	_	_	_	_
55	disease	_	_	_	_	_	_	_	_
56	is	_	_	_	_	_	_	_	_
57	very	_	_	_	_	_	_	_	_
58	important	_	_	_	_	_	_	_	_
59	for	_	_	_	_	_	_	_	_
60	its	_	_	_	_	_	_	_	_
61	identification	_	_	_	_	_	_	_	_
62	and	_	_	_	_	_	_	_	_
63	proper	_	_	_	_	_	_	_	_
64	management	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
66	Accurate	_	_	_	_	_	_	_	BeginSeg=Yes
67	information	_	_	_	_	_	_	_	_
68	on	_	_	_	_	_	_	_	_
69	the	_	_	_	_	_	_	_	_
70	disease	_	_	_	_	_	_	_	_
71	,	_	_	_	_	_	_	_	_
72	its	_	_	_	_	_	_	_	_
73	prevention	_	_	_	_	_	_	_	_
74	and	_	_	_	_	_	_	_	_
75	treatment	_	_	_	_	_	_	_	_
76	can	_	_	_	_	_	_	_	_
77	be	_	_	_	_	_	_	_	_
78	disseminated	_	_	_	_	_	_	_	_
79	through	_	_	_	_	_	_	_	_
80	drug	_	_	_	_	_	_	_	_
81	information	_	_	_	_	_	_	_	_
82	centers	_	_	_	_	_	_	_	_
83	(	_	_	_	_	_	_	_	_
84	DICs	_	_	_	_	_	_	_	_
85	)	_	_	_	_	_	_	_	_
86	.	_	_	_	_	_	_	_	_
87	DICs	_	_	_	_	_	_	_	BeginSeg=Yes
88	are	_	_	_	_	_	_	_	_
89	usually	_	_	_	_	_	_	_	_
90	staffed	_	_	_	_	_	_	_	_
91	by	_	_	_	_	_	_	_	_
92	pharmacists	_	_	_	_	_	_	_	_
93	and/or	_	_	_	_	_	_	_	_
94	clinical	_	_	_	_	_	_	_	_
95	pharmacists	_	_	_	_	_	_	_	_
96	/	_	_	_	_	_	_	_	_
97	pharmacologists	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	DICs	_	_	_	_	_	_	_	BeginSeg=Yes
100	are	_	_	_	_	_	_	_	_
101	a	_	_	_	_	_	_	_	_
102	reliable	_	_	_	_	_	_	_	_
103	source	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	current	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	unbiased	_	_	_	_	_	_	_	_
108	information	_	_	_	_	_	_	_	_
109	on	_	_	_	_	_	_	_	_
110	COVID-19	_	_	_	_	_	_	_	_
111	and	_	_	_	_	_	_	_	_
112	its	_	_	_	_	_	_	_	_
113	associated	_	_	_	_	_	_	_	_
114	complications	_	_	_	_	_	_	_	_
115	,	_	_	_	_	_	_	_	_
116	including	_	_	_	_	_	_	_	BeginSeg=Yes
117	management	_	_	_	_	_	_	_	_
118	options	_	_	_	_	_	_	_	_
119	for	_	_	_	_	_	_	_	_
120	healthcare	_	_	_	_	_	_	_	_
121	professionals	_	_	_	_	_	_	_	_
122	and	_	_	_	_	_	_	_	_
123	the	_	_	_	_	_	_	_	_
124	public	_	_	_	_	_	_	_	_
125	.	_	_	_	_	_	_	_	_
126	In	_	_	_	_	_	_	_	BeginSeg=Yes
127	addition	_	_	_	_	_	_	_	_
128	to	_	_	_	_	_	_	_	_
129	health	_	_	_	_	_	_	_	_
130	and	_	_	_	_	_	_	_	_
131	drug	_	_	_	_	_	_	_	_
132	information	_	_	_	_	_	_	_	_
133	,	_	_	_	_	_	_	_	_
134	pharmacists	_	_	_	_	_	_	_	_
135	working	_	_	_	_	_	_	_	BeginSeg=Yes
136	in	_	_	_	_	_	_	_	_
137	the	_	_	_	_	_	_	_	_
138	DICs	_	_	_	_	_	_	_	_
139	can	_	_	_	_	_	_	_	BeginSeg=Yes
140	be	_	_	_	_	_	_	_	_
141	involved	_	_	_	_	_	_	_	_
142	in	_	_	_	_	_	_	_	_
143	the	_	_	_	_	_	_	_	_
144	management	_	_	_	_	_	_	_	_
145	of	_	_	_	_	_	_	_	_
146	the	_	_	_	_	_	_	_	_
147-148	patients'	_	_	_	_	_	_	_	_
147	patients	_	_	_	_	_	_	_	_
148	'	_	_	_	_	_	_	_	_
149	health	_	_	_	_	_	_	_	_
150	by	_	_	_	_	_	_	_	BeginSeg=Yes
151	providing	_	_	_	_	_	_	_	_
152	information	_	_	_	_	_	_	_	_
153	on	_	_	_	_	_	_	_	_
154	home	_	_	_	_	_	_	_	_
155	care	_	_	_	_	_	_	_	_
156	and	_	_	_	_	_	_	_	_
157	safety	_	_	_	_	_	_	_	_
158	,	_	_	_	_	_	_	_	_
159	medication	_	_	_	_	_	_	_	BeginSeg=Yes
160	management	_	_	_	_	_	_	_	_
161	of	_	_	_	_	_	_	_	_
162	patients	_	_	_	_	_	_	_	_
163	with	_	_	_	_	_	_	_	_
164	chronic	_	_	_	_	_	_	_	_
165	comorbid	_	_	_	_	_	_	_	_
166	illnesses	_	_	_	_	_	_	_	_
167	,	_	_	_	_	_	_	_	_
168	and	_	_	_	_	_	_	_	_
169	psychological	_	_	_	_	_	_	_	_
170	advice	_	_	_	_	_	_	_	_
171	.	_	_	_	_	_	_	_	_
172	This	_	_	_	_	_	_	_	BeginSeg=Yes
173	article	_	_	_	_	_	_	_	_
174	explores	_	_	_	_	_	_	_	_
175	the	_	_	_	_	_	_	_	_
176	possible	_	_	_	_	_	_	_	_
177	additional	_	_	_	_	_	_	_	_
178	roles	_	_	_	_	_	_	_	_
179	DICs	_	_	_	_	_	_	_	BeginSeg=Yes
180	can	_	_	_	_	_	_	_	_
181	play	_	_	_	_	_	_	_	_
182	,	_	_	_	_	_	_	_	_
183	besides	_	_	_	_	_	_	_	BeginSeg=Yes
184	providing	_	_	_	_	_	_	_	_
185	drug	_	_	_	_	_	_	_	_
186	information	_	_	_	_	_	_	_	_
187	within	_	_	_	_	_	_	_	_
188	the	_	_	_	_	_	_	_	_
189	hospital	_	_	_	_	_	_	_	_
190	or	_	_	_	_	_	_	_	_
191	in	_	_	_	_	_	_	_	_
192	the	_	_	_	_	_	_	_	_
193	community	_	_	_	_	_	_	_	_
194	.	_	_	_	_	_	_	_	_
195	All	_	_	_	_	_	_	_	BeginSeg=Yes
196	authors	_	_	_	_	_	_	_	_
197	have	_	_	_	_	_	_	_	_
198	an	_	_	_	_	_	_	_	_
199	equal	_	_	_	_	_	_	_	_
200	contribution	_	_	_	_	_	_	_	_
201	.	_	_	_	_	_	_	_	_

# newdoc_id = 5b775e63051b1d160f67b9734aa57f1b56df5e5d
1	Invasive	_	_	_	_	_	_	_	BeginSeg=Yes
2	,	_	_	_	_	_	_	_	_
3	non	_	_	_	_	_	_	_	_
4	-	_	_	_	_	_	_	_	_
5	native	_	_	_	_	_	_	_	_
6	species	_	_	_	_	_	_	_	_
7	are	_	_	_	_	_	_	_	_
8	a	_	_	_	_	_	_	_	_
9	major	_	_	_	_	_	_	_	_
10	threat	_	_	_	_	_	_	_	_
11	to	_	_	_	_	_	_	_	_
12	global	_	_	_	_	_	_	_	_
13	biodiversity	_	_	_	_	_	_	_	_
14	.	_	_	_	_	_	_	_	_
15	Stoats	_	_	_	_	_	_	_	BeginSeg=Yes
16	were	_	_	_	_	_	_	_	_
17	introduced	_	_	_	_	_	_	_	_
18	from	_	_	_	_	_	_	_	_
19	Britain	_	_	_	_	_	_	_	_
20	to	_	_	_	_	_	_	_	_
21	New	_	_	_	_	_	_	_	_
22	Zealand	_	_	_	_	_	_	_	_
23	in	_	_	_	_	_	_	_	_
24	the	_	_	_	_	_	_	_	_
25	1880s	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	BeginSeg=Yes
27	have	_	_	_	_	_	_	_	_
28	since	_	_	_	_	_	_	_	_
29	caused	_	_	_	_	_	_	_	_
30	grave	_	_	_	_	_	_	_	_
31	conservation	_	_	_	_	_	_	_	_
32	problems	_	_	_	_	_	_	_	_
33	.	_	_	_	_	_	_	_	_
34	A	_	_	_	_	_	_	_	BeginSeg=Yes
35	histopathological	_	_	_	_	_	_	_	_
36	and	_	_	_	_	_	_	_	_
37	serological	_	_	_	_	_	_	_	_
38	survey	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	disease	_	_	_	_	_	_	_	_
41	and	_	_	_	_	_	_	_	_
42	infection	_	_	_	_	_	_	_	_
43	in	_	_	_	_	_	_	_	_
44	stoats	_	_	_	_	_	_	_	_
45	from	_	_	_	_	_	_	_	_
46	New	_	_	_	_	_	_	_	_
47	Zealand	_	_	_	_	_	_	_	_
48	was	_	_	_	_	_	_	_	_
49	undertaken	_	_	_	_	_	_	_	_
50	to	_	_	_	_	_	_	_	BeginSeg=Yes
51	identify	_	_	_	_	_	_	_	_
52	agents	_	_	_	_	_	_	_	_
53	that	_	_	_	_	_	_	_	BeginSeg=Yes
54	might	_	_	_	_	_	_	_	_
55	be	_	_	_	_	_	_	_	_
56	used	_	_	_	_	_	_	_	_
57	or	_	_	_	_	_	_	_	_
58	modified	_	_	_	_	_	_	_	_
59	to	_	_	_	_	_	_	_	BeginSeg=Yes
60	control	_	_	_	_	_	_	_	_
61	this	_	_	_	_	_	_	_	_
62	population	_	_	_	_	_	_	_	_
63	.	_	_	_	_	_	_	_	_
64	Of	_	_	_	_	_	_	_	BeginSeg=Yes
65	60	_	_	_	_	_	_	_	_
66	stoats	_	_	_	_	_	_	_	_
67	examined	_	_	_	_	_	_	_	_
68	,	_	_	_	_	_	_	_	_
69	63	_	_	_	_	_	_	_	_
70	%	_	_	_	_	_	_	_	_
71	exhibited	_	_	_	_	_	_	_	_
72	inflammation	_	_	_	_	_	_	_	_
73	of	_	_	_	_	_	_	_	_
74	the	_	_	_	_	_	_	_	_
75	lung	_	_	_	_	_	_	_	_
76	,	_	_	_	_	_	_	_	_
77	mostly	_	_	_	_	_	_	_	BeginSeg=Yes
78	occurring	_	_	_	_	_	_	_	_
79	as	_	_	_	_	_	_	_	_
80	local	_	_	_	_	_	_	_	_
81	or	_	_	_	_	_	_	_	_
82	diffuse	_	_	_	_	_	_	_	_
83	interstitial	_	_	_	_	_	_	_	_
84	pneumonia	_	_	_	_	_	_	_	_
85	,	_	_	_	_	_	_	_	_
86	30	_	_	_	_	_	_	_	BeginSeg=Yes
87	%	_	_	_	_	_	_	_	_
88	showed	_	_	_	_	_	_	_	_
89	signs	_	_	_	_	_	_	_	_
90	of	_	_	_	_	_	_	_	_
91	inflammatory	_	_	_	_	_	_	_	_
92	liver	_	_	_	_	_	_	_	_
93	disease	_	_	_	_	_	_	_	_
94	and	_	_	_	_	_	_	_	BeginSeg=Yes
95	14	_	_	_	_	_	_	_	_
96	%	_	_	_	_	_	_	_	_
97	were	_	_	_	_	_	_	_	_
98	positive	_	_	_	_	_	_	_	_
99	for	_	_	_	_	_	_	_	_
100	antibodies	_	_	_	_	_	_	_	_
101	reactive	_	_	_	_	_	_	_	_
102	with	_	_	_	_	_	_	_	_
103	feline	_	_	_	_	_	_	_	_
104	calicivirus	_	_	_	_	_	_	_	_
105	.	_	_	_	_	_	_	_	_
106	In	_	_	_	_	_	_	_	BeginSeg=Yes
107	Britain	_	_	_	_	_	_	_	_
108	only	_	_	_	_	_	_	_	_
109	11	_	_	_	_	_	_	_	_
110	%	_	_	_	_	_	_	_	_
111	of	_	_	_	_	_	_	_	_
112	44	_	_	_	_	_	_	_	_
113	stoats	_	_	_	_	_	_	_	_
114	exhibited	_	_	_	_	_	_	_	_
115	symptoms	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	pulmonary	_	_	_	_	_	_	_	_
118	inflammatory	_	_	_	_	_	_	_	_
119	disease	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	suggesting	_	_	_	_	_	_	_	BeginSeg=Yes
122	higher	_	_	_	_	_	_	_	_
123	rates	_	_	_	_	_	_	_	_
124	of	_	_	_	_	_	_	_	_
125	infection	_	_	_	_	_	_	_	_
126	or	_	_	_	_	_	_	_	_
127	compromise	_	_	_	_	_	_	_	_
128	of	_	_	_	_	_	_	_	_
129	the	_	_	_	_	_	_	_	_
130	pulmonary	_	_	_	_	_	_	_	_
131	immune	_	_	_	_	_	_	_	_
132	system	_	_	_	_	_	_	_	_
133	among	_	_	_	_	_	_	_	_
134	invasive	_	_	_	_	_	_	_	_
135	stoats	_	_	_	_	_	_	_	_
136	,	_	_	_	_	_	_	_	_
137	possibly	_	_	_	_	_	_	_	BeginSeg=Yes
138	related	_	_	_	_	_	_	_	_
139	to	_	_	_	_	_	_	_	_
140	genetic	_	_	_	_	_	_	_	_
141	founder	_	_	_	_	_	_	_	_
142	effects	_	_	_	_	_	_	_	_
143	or	_	_	_	_	_	_	_	_
144	environmental	_	_	_	_	_	_	_	_
145	variation	_	_	_	_	_	_	_	_
146	.	_	_	_	_	_	_	_	_
147	These	_	_	_	_	_	_	_	BeginSeg=Yes
148	findings	_	_	_	_	_	_	_	_
149	could	_	_	_	_	_	_	_	_
150	be	_	_	_	_	_	_	_	_
151	exploited	_	_	_	_	_	_	_	_
152	in	_	_	_	_	_	_	_	_
153	biological	_	_	_	_	_	_	_	_
154	control	_	_	_	_	_	_	_	_
155	programmes	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_

# newdoc_id = 5cd27ed55a88051c9919a142ae44719c2274eb5a
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	world	_	_	_	_	_	_	_	_
3	is	_	_	_	_	_	_	_	_
4	facing	_	_	_	_	_	_	_	_
5	a	_	_	_	_	_	_	_	_
6	medical	_	_	_	_	_	_	_	_
7	crisis	_	_	_	_	_	_	_	_
8	amid	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	CoViD-19	_	_	_	_	_	_	_	_
11	pandemic	_	_	_	_	_	_	_	_
12	and	_	_	_	_	_	_	_	BeginSeg=Yes
13	the	_	_	_	_	_	_	_	_
14	role	_	_	_	_	_	_	_	_
15	of	_	_	_	_	_	_	_	_
16	adequate	_	_	_	_	_	_	_	_
17	hygiene	_	_	_	_	_	_	_	_
18	and	_	_	_	_	_	_	_	_
19	hand	_	_	_	_	_	_	_	_
20	sanitisers	_	_	_	_	_	_	_	_
21	is	_	_	_	_	_	_	_	_
22	inevitable	_	_	_	_	_	_	_	_
23	in	_	_	_	_	_	_	_	BeginSeg=Yes
24	controlling	_	_	_	_	_	_	_	_
25	the	_	_	_	_	_	_	_	_
26	spread	_	_	_	_	_	_	_	_
27	of	_	_	_	_	_	_	_	_
28	infection	_	_	_	_	_	_	_	_
29	in	_	_	_	_	_	_	_	_
30	public	_	_	_	_	_	_	_	_
31	places	_	_	_	_	_	_	_	_
32	and	_	_	_	_	_	_	_	_
33	healthcare	_	_	_	_	_	_	_	_
34	institutions	_	_	_	_	_	_	_	_
35	.	_	_	_	_	_	_	_	_
36	There	_	_	_	_	_	_	_	BeginSeg=Yes
37	has	_	_	_	_	_	_	_	_
38	been	_	_	_	_	_	_	_	_
39	a	_	_	_	_	_	_	_	_
40	great	_	_	_	_	_	_	_	_
41	surge	_	_	_	_	_	_	_	_
42	in	_	_	_	_	_	_	_	_
43	demand	_	_	_	_	_	_	_	_
44	for	_	_	_	_	_	_	_	_
45	hand	_	_	_	_	_	_	_	_
46	sanitisation	_	_	_	_	_	_	_	_
47	products	_	_	_	_	_	_	_	_
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49	to	_	_	_	_	_	_	_	_
50	shortages	_	_	_	_	_	_	_	_
51	in	_	_	_	_	_	_	_	_
52	their	_	_	_	_	_	_	_	_
53	supply	_	_	_	_	_	_	_	_
54	.	_	_	_	_	_	_	_	_
55	A	_	_	_	_	_	_	_	BeginSeg=Yes
56	consequent	_	_	_	_	_	_	_	_
57	increase	_	_	_	_	_	_	_	_
58	of	_	_	_	_	_	_	_	_
59	substandard	_	_	_	_	_	_	_	_
60	products	_	_	_	_	_	_	_	_
61	in	_	_	_	_	_	_	_	_
62	the	_	_	_	_	_	_	_	_
63	market	_	_	_	_	_	_	_	_
64	has	_	_	_	_	_	_	_	_
65	raised	_	_	_	_	_	_	_	_
66	safety	_	_	_	_	_	_	_	_
67	concerns	_	_	_	_	_	_	_	_
68	.	_	_	_	_	_	_	_	_
69	This	_	_	_	_	_	_	_	BeginSeg=Yes
70	article	_	_	_	_	_	_	_	_
71	,	_	_	_	_	_	_	_	_
72	therefore	_	_	_	_	_	_	_	_
73	,	_	_	_	_	_	_	_	_
74	presents	_	_	_	_	_	_	_	_
75	a	_	_	_	_	_	_	_	_
76	critical	_	_	_	_	_	_	_	_
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78	of	_	_	_	_	_	_	_	_
79	hand	_	_	_	_	_	_	_	_
80	sanitation	_	_	_	_	_	_	_	_
81	approaches	_	_	_	_	_	_	_	_
82	and	_	_	_	_	_	_	_	_
83	products	_	_	_	_	_	_	_	_
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85	on	_	_	_	_	_	_	_	_
86	the	_	_	_	_	_	_	_	_
87	market	_	_	_	_	_	_	_	_
88	in	_	_	_	_	_	_	_	_
89	light	_	_	_	_	_	_	_	_
90	of	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
92	scientific	_	_	_	_	_	_	_	_
93	evidence	_	_	_	_	_	_	_	_
94	available	_	_	_	_	_	_	_	_
95	to	_	_	_	_	_	_	_	_
96	date	_	_	_	_	_	_	_	_
97	.	_	_	_	_	_	_	_	_
98	This	_	_	_	_	_	_	_	BeginSeg=Yes
99	review	_	_	_	_	_	_	_	_
100	also	_	_	_	_	_	_	_	_
101	provides	_	_	_	_	_	_	_	_
102	a	_	_	_	_	_	_	_	_
103	range	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	hand	_	_	_	_	_	_	_	_
106	sanitisation	_	_	_	_	_	_	_	_
107	product	_	_	_	_	_	_	_	_
108	formulations	_	_	_	_	_	_	_	_
109	,	_	_	_	_	_	_	_	_
110	and	_	_	_	_	_	_	_	_
111	manufacturing	_	_	_	_	_	_	_	_
112	instructions	_	_	_	_	_	_	_	_
113	to	_	_	_	_	_	_	_	BeginSeg=Yes
114	allow	_	_	_	_	_	_	_	_
115	for	_	_	_	_	_	_	_	_
116	extemporaneous	_	_	_	_	_	_	_	_
117	preparations	_	_	_	_	_	_	_	_
118	at	_	_	_	_	_	_	_	_
119	the	_	_	_	_	_	_	_	_
120	community	_	_	_	_	_	_	_	_
121	and	_	_	_	_	_	_	_	_
122	hospital	_	_	_	_	_	_	_	_
123	pharmacies	_	_	_	_	_	_	_	_
124	during	_	_	_	_	_	_	_	_
125	this	_	_	_	_	_	_	_	_
126	urgent	_	_	_	_	_	_	_	_
127	crisis	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_
129	In	_	_	_	_	_	_	_	BeginSeg=Yes
130	addition	_	_	_	_	_	_	_	_
131	,	_	_	_	_	_	_	_	_
132	this	_	_	_	_	_	_	_	_
133	emergent	_	_	_	_	_	_	_	_
134	situation	_	_	_	_	_	_	_	_
135	is	_	_	_	_	_	_	_	_
136	expected	_	_	_	_	_	_	_	_
137	to	_	_	_	_	_	_	_	_
138	continue	_	_	_	_	_	_	_	_
139	,	_	_	_	_	_	_	_	_
140	hence	_	_	_	_	_	_	_	BeginSeg=Yes
141	hand	_	_	_	_	_	_	_	_
142	sanitisers	_	_	_	_	_	_	_	_
143	will	_	_	_	_	_	_	_	_
144	be	_	_	_	_	_	_	_	_
145	in	_	_	_	_	_	_	_	_
146	demand	_	_	_	_	_	_	_	_
147	for	_	_	_	_	_	_	_	_
148	an	_	_	_	_	_	_	_	_
149	extended	_	_	_	_	_	_	_	_
150	time	_	_	_	_	_	_	_	_
151	,	_	_	_	_	_	_	_	_
152	and	_	_	_	_	_	_	_	BeginSeg=Yes
153	the	_	_	_	_	_	_	_	_
154	availability	_	_	_	_	_	_	_	_
155	and	_	_	_	_	_	_	_	_
156	purchase	_	_	_	_	_	_	_	_
157	of	_	_	_	_	_	_	_	_
158	substandard	_	_	_	_	_	_	_	_
159	products	_	_	_	_	_	_	_	_
160	on	_	_	_	_	_	_	_	_
161	the	_	_	_	_	_	_	_	_
162	market	_	_	_	_	_	_	_	_
163	create	_	_	_	_	_	_	_	_
164	an	_	_	_	_	_	_	_	_
165	ongoing	_	_	_	_	_	_	_	_
166	safety	_	_	_	_	_	_	_	_
167	concern	_	_	_	_	_	_	_	_
168	.	_	_	_	_	_	_	_	_
169	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
170	,	_	_	_	_	_	_	_	_
171	this	_	_	_	_	_	_	_	_
172	article	_	_	_	_	_	_	_	_
173	shall	_	_	_	_	_	_	_	_
174	also	_	_	_	_	_	_	_	_
175	provide	_	_	_	_	_	_	_	_
176	various	_	_	_	_	_	_	_	_
177	commercial	_	_	_	_	_	_	_	_
178	organisations	_	_	_	_	_	_	_	_
179	,	_	_	_	_	_	_	_	_
180	interested	_	_	_	_	_	_	_	BeginSeg=Yes
181	in	_	_	_	_	_	_	_	_
182	stepping	_	_	_	_	_	_	_	_
183	forward	_	_	_	_	_	_	_	_
184	the	_	_	_	_	_	_	_	_
185	production	_	_	_	_	_	_	_	_
186	and	_	_	_	_	_	_	_	_
187	marketing	_	_	_	_	_	_	_	_
188	of	_	_	_	_	_	_	_	_
189	hand	_	_	_	_	_	_	_	_
190	sanitisers	_	_	_	_	_	_	_	_
191	,	_	_	_	_	_	_	_	_
192	with	_	_	_	_	_	_	_	_
193	a	_	_	_	_	_	_	_	_
194	guide	_	_	_	_	_	_	_	_
195	on	_	_	_	_	_	_	_	_
196	the	_	_	_	_	_	_	_	_
197	development	_	_	_	_	_	_	_	_
198	of	_	_	_	_	_	_	_	_
199	products	_	_	_	_	_	_	_	_
200	of	_	_	_	_	_	_	_	_
201	standardised	_	_	_	_	_	_	_	_
202	ingredients	_	_	_	_	_	_	_	_
203	and	_	_	_	_	_	_	_	_
204	formulations	_	_	_	_	_	_	_	_
205	.	_	_	_	_	_	_	_	_

# newdoc_id = 5d2ed78357c0c88b4500d644f4a717d0192a0d2d
1	In	_	_	_	_	_	_	_	BeginSeg=Yes
2	the	_	_	_	_	_	_	_	_
3	present	_	_	_	_	_	_	_	_
4	studies	_	_	_	_	_	_	_	_
5	,	_	_	_	_	_	_	_	_
6	we	_	_	_	_	_	_	_	_
7	report	_	_	_	_	_	_	_	_
8	the	_	_	_	_	_	_	_	_
9	cloning	_	_	_	_	_	_	_	_
10	and	_	_	_	_	_	_	_	_
11	structural	_	_	_	_	_	_	_	_
12	characterization	_	_	_	_	_	_	_	_
13	of	_	_	_	_	_	_	_	_
14	the	_	_	_	_	_	_	_	_
15	HFGL2	_	_	_	_	_	_	_	_
16	gene	_	_	_	_	_	_	_	_
17	and	_	_	_	_	_	_	_	_
18	its	_	_	_	_	_	_	_	_
19	functional	_	_	_	_	_	_	_	_
20	role	_	_	_	_	_	_	_	_
21	in	_	_	_	_	_	_	_	_
22	human	_	_	_	_	_	_	_	_
23	fulminant	_	_	_	_	_	_	_	_
24	hepatitis	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	The	_	_	_	_	_	_	_	BeginSeg=Yes
27	HFGL2	_	_	_	_	_	_	_	_
28	gene	_	_	_	_	_	_	_	_
29	is	_	_	_	_	_	_	_	_
30	approximately	_	_	_	_	_	_	_	_
31	7	_	_	_	_	_	_	_	_
32	kb	_	_	_	_	_	_	_	_
33	in	_	_	_	_	_	_	_	_
34	length	_	_	_	_	_	_	_	_
35	with	_	_	_	_	_	_	_	_
36	2	_	_	_	_	_	_	_	_
37	exons	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
39	The	_	_	_	_	_	_	_	BeginSeg=Yes
40	putative	_	_	_	_	_	_	_	_
41	promoter	_	_	_	_	_	_	_	_
42	contains	_	_	_	_	_	_	_	_
43	cis	_	_	_	_	_	_	_	_
44	element	_	_	_	_	_	_	_	_
45	consensus	_	_	_	_	_	_	_	_
46	sequences	_	_	_	_	_	_	_	_
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48	strongly	_	_	_	_	_	_	_	_
49	suggest	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	inducibility	_	_	_	_	_	_	_	_
52	of	_	_	_	_	_	_	_	_
53	its	_	_	_	_	_	_	_	_
54	expression	_	_	_	_	_	_	_	_
55	.	_	_	_	_	_	_	_	_
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57	the	_	_	_	_	_	_	_	_
58	nucleotide	_	_	_	_	_	_	_	_
59	sequence	_	_	_	_	_	_	_	_
60	of	_	_	_	_	_	_	_	_
61	the	_	_	_	_	_	_	_	_
62	human	_	_	_	_	_	_	_	_
63	gene	_	_	_	_	_	_	_	_
64	,	_	_	_	_	_	_	_	_
65	a	_	_	_	_	_	_	_	_
66	439-amino	_	_	_	_	_	_	_	_
67	acid	_	_	_	_	_	_	_	_
68	long	_	_	_	_	_	_	_	_
69	protein	_	_	_	_	_	_	_	_
70	is	_	_	_	_	_	_	_	_
71	predicted	_	_	_	_	_	_	_	_
72	.	_	_	_	_	_	_	_	_
73	The	_	_	_	_	_	_	_	BeginSeg=Yes
74	overall	_	_	_	_	_	_	_	_
75	identity	_	_	_	_	_	_	_	_
76	between	_	_	_	_	_	_	_	_
77	the	_	_	_	_	_	_	_	_
78	murine	_	_	_	_	_	_	_	_
79	fgl2	_	_	_	_	_	_	_	_
80	and	_	_	_	_	_	_	_	_
81	hfgl2	_	_	_	_	_	_	_	_
82	coded	_	_	_	_	_	_	_	_
83	proteins	_	_	_	_	_	_	_	_
84	is	_	_	_	_	_	_	_	_
85	over	_	_	_	_	_	_	_	_
86	70	_	_	_	_	_	_	_	_
87	%	_	_	_	_	_	_	_	_
88	.	_	_	_	_	_	_	_	_
89	About	_	_	_	_	_	_	_	BeginSeg=Yes
90	225	_	_	_	_	_	_	_	_
91	amino	_	_	_	_	_	_	_	_
92	acids	_	_	_	_	_	_	_	_
93	at	_	_	_	_	_	_	_	_
94	the	_	_	_	_	_	_	_	_
95	carboxyl	_	_	_	_	_	_	_	_
96	end	_	_	_	_	_	_	_	_
97	of	_	_	_	_	_	_	_	_
98	these	_	_	_	_	_	_	_	_
99	molecules	_	_	_	_	_	_	_	_
100	are	_	_	_	_	_	_	_	_
101	almost	_	_	_	_	_	_	_	_
102	90	_	_	_	_	_	_	_	_
103	%	_	_	_	_	_	_	_	_
104	identical	_	_	_	_	_	_	_	_
105	,	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	BeginSeg=Yes
107	correspond	_	_	_	_	_	_	_	_
108	to	_	_	_	_	_	_	_	_
109	a	_	_	_	_	_	_	_	_
110	well	_	_	_	_	_	_	_	_
111	-	_	_	_	_	_	_	_	_
112	conserved	_	_	_	_	_	_	_	_
113	fibrinogen	_	_	_	_	_	_	_	_
114	-	_	_	_	_	_	_	_	_
115	related	_	_	_	_	_	_	_	_
116	domain	_	_	_	_	_	_	_	_
117	.	_	_	_	_	_	_	_	_
118	Both	_	_	_	_	_	_	_	BeginSeg=Yes
119	HFGL2	_	_	_	_	_	_	_	_
120	and	_	_	_	_	_	_	_	_
121	FGL2	_	_	_	_	_	_	_	_
122	encode	_	_	_	_	_	_	_	_
123	a	_	_	_	_	_	_	_	_
124	type	_	_	_	_	_	_	_	_
125	II	_	_	_	_	_	_	_	_
126	transmembrane	_	_	_	_	_	_	_	_
127	protein	_	_	_	_	_	_	_	_
128	with	_	_	_	_	_	_	_	_
129	a	_	_	_	_	_	_	_	_
130	predicted	_	_	_	_	_	_	_	_
131	catalytic	_	_	_	_	_	_	_	_
132	domain	_	_	_	_	_	_	_	_
133	toward	_	_	_	_	_	_	_	_
134	the	_	_	_	_	_	_	_	_
135	amino	_	_	_	_	_	_	_	_
136	terminus	_	_	_	_	_	_	_	_
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138	the	_	_	_	_	_	_	_	_
139	protein	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	Transient	_	_	_	_	_	_	_	BeginSeg=Yes
142	transfection	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	Chinese	_	_	_	_	_	_	_	_
145	hamster	_	_	_	_	_	_	_	_
146	ovary	_	_	_	_	_	_	_	_
147	(	_	_	_	_	_	_	_	_
148	CHO	_	_	_	_	_	_	_	_
149	)	_	_	_	_	_	_	_	_
150	cells	_	_	_	_	_	_	_	_
151	with	_	_	_	_	_	_	_	_
152	a	_	_	_	_	_	_	_	_
153	fulllength	_	_	_	_	_	_	_	_
154	cDNA	_	_	_	_	_	_	_	_
155	of	_	_	_	_	_	_	_	_
156	HFGL2	_	_	_	_	_	_	_	_
157	coding	_	_	_	_	_	_	_	_
158	region	_	_	_	_	_	_	_	_
159	resulted	_	_	_	_	_	_	_	_
160	in	_	_	_	_	_	_	_	_
161	high	_	_	_	_	_	_	_	_
162	levels	_	_	_	_	_	_	_	_
163	of	_	_	_	_	_	_	_	_
164	prothrombinase	_	_	_	_	_	_	_	_
165	activity	_	_	_	_	_	_	_	_
166	.	_	_	_	_	_	_	_	_
167	Livers	_	_	_	_	_	_	_	BeginSeg=Yes
168	from	_	_	_	_	_	_	_	_
169	8	_	_	_	_	_	_	_	_
170	patients	_	_	_	_	_	_	_	_
171	transplanted	_	_	_	_	_	_	_	BeginSeg=Yes
172	for	_	_	_	_	_	_	_	_
173	fulminant	_	_	_	_	_	_	_	_
174	viral	_	_	_	_	_	_	_	_
175	hepatitis	_	_	_	_	_	_	_	_
176	were	_	_	_	_	_	_	_	BeginSeg=Yes
177	examined	_	_	_	_	_	_	_	_
178	for	_	_	_	_	_	_	_	_
179	extent	_	_	_	_	_	_	_	_
180	of	_	_	_	_	_	_	_	_
181	necrosis	_	_	_	_	_	_	_	_
182	,	_	_	_	_	_	_	_	_
183	inflammation	_	_	_	_	_	_	_	_
184	,	_	_	_	_	_	_	_	_
185	fibrin	_	_	_	_	_	_	_	_
186	deposition	_	_	_	_	_	_	_	_
187	,	_	_	_	_	_	_	_	_
188	and	_	_	_	_	_	_	_	_
189	HFGL2	_	_	_	_	_	_	_	_
190	induction	_	_	_	_	_	_	_	_
191	.	_	_	_	_	_	_	_	_
192	In	_	_	_	_	_	_	_	BeginSeg=Yes
193	situ	_	_	_	_	_	_	_	_
194	hybridization	_	_	_	_	_	_	_	_
195	showed	_	_	_	_	_	_	_	_
196	positive	_	_	_	_	_	_	_	_
197	staining	_	_	_	_	_	_	_	_
198	of	_	_	_	_	_	_	_	_
199	macrophages	_	_	_	_	_	_	_	_
200	in	_	_	_	_	_	_	_	_
201	areas	_	_	_	_	_	_	_	_
202	of	_	_	_	_	_	_	_	_
203	active	_	_	_	_	_	_	_	_
204	hepatocellular	_	_	_	_	_	_	_	_
205	necrosis	_	_	_	_	_	_	_	_
206	.	_	_	_	_	_	_	_	_
207	Fibrin	_	_	_	_	_	_	_	BeginSeg=Yes
208	stained	_	_	_	_	_	_	_	_
209	positively	_	_	_	_	_	_	_	_
210	in	_	_	_	_	_	_	_	_
211	these	_	_	_	_	_	_	_	_
212	areas	_	_	_	_	_	_	_	_
213	and	_	_	_	_	_	_	_	BeginSeg=Yes
214	was	_	_	_	_	_	_	_	_
215	confirmed	_	_	_	_	_	_	_	_
216	by	_	_	_	_	_	_	_	_
217	electron	_	_	_	_	_	_	_	_
218	microscopy	_	_	_	_	_	_	_	_
219	.	_	_	_	_	_	_	_	_
220	These	_	_	_	_	_	_	_	BeginSeg=Yes
221	studies	_	_	_	_	_	_	_	_
222	define	_	_	_	_	_	_	_	_
223	a	_	_	_	_	_	_	_	_
224	unique	_	_	_	_	_	_	_	_
225	prothrombinase	_	_	_	_	_	_	_	_
226	gene	_	_	_	_	_	_	_	_
227	(	_	_	_	_	_	_	_	_
228	HFGL2	_	_	_	_	_	_	_	_
229	)	_	_	_	_	_	_	_	_
230	and	_	_	_	_	_	_	_	BeginSeg=Yes
231	implicate	_	_	_	_	_	_	_	_
232	its	_	_	_	_	_	_	_	_
233	importance	_	_	_	_	_	_	_	_
234	in	_	_	_	_	_	_	_	_
235	the	_	_	_	_	_	_	_	_
236	pathogenesis	_	_	_	_	_	_	_	_
237	of	_	_	_	_	_	_	_	_
238	fulminant	_	_	_	_	_	_	_	_
239	viral	_	_	_	_	_	_	_	_
240	hepatitis	_	_	_	_	_	_	_	_
241	.	_	_	_	_	_	_	_	_

# newdoc_id = 5daee51840f3c189675dbb151da2abb907ab6a96
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	COVID19	_	_	_	_	_	_	_	_
3	pandemic	_	_	_	_	_	_	_	_
4	,	_	_	_	_	_	_	_	_
5	designated	_	_	_	_	_	_	_	BeginSeg=Yes
6	as	_	_	_	_	_	_	_	_
7	a	_	_	_	_	_	_	_	_
8	public	_	_	_	_	_	_	_	_
9	health	_	_	_	_	_	_	_	_
10	crisis	_	_	_	_	_	_	_	_
11	by	_	_	_	_	_	_	_	_
12	the	_	_	_	_	_	_	_	_
13	World	_	_	_	_	_	_	_	_
14	Health	_	_	_	_	_	_	_	_
15	Organization	_	_	_	_	_	_	_	_
16	(	_	_	_	_	_	_	_	_
17	WHO	_	_	_	_	_	_	_	_
18	)	_	_	_	_	_	_	_	_
19	,	_	_	_	_	_	_	_	_
20	is	_	_	_	_	_	_	_	BeginSeg=Yes
21	rapidly	_	_	_	_	_	_	_	_
22	spreading	_	_	_	_	_	_	_	_
23	around	_	_	_	_	_	_	_	_
24	the	_	_	_	_	_	_	_	_
25	world	_	_	_	_	_	_	_	_
26	impacting	_	_	_	_	_	_	_	BeginSeg=Yes
27	the	_	_	_	_	_	_	_	_
28	health	_	_	_	_	_	_	_	_
29	and	_	_	_	_	_	_	_	_
30	economy	_	_	_	_	_	_	_	_
31	of	_	_	_	_	_	_	_	_
32	almost	_	_	_	_	_	_	_	_
33	all	_	_	_	_	_	_	_	_
34	the	_	_	_	_	_	_	_	_
35	countries	_	_	_	_	_	_	_	_
36	.	_	_	_	_	_	_	_	_
37	The	_	_	_	_	_	_	_	BeginSeg=Yes
38	data	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	hospitalized	_	_	_	_	_	_	_	_
41	COVID19	_	_	_	_	_	_	_	_
42	patients	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	especially	_	_	_	_	_	_	_	_
45	those	_	_	_	_	_	_	_	_
46	with	_	_	_	_	_	_	_	_
47	serious	_	_	_	_	_	_	_	_
48	illness	_	_	_	_	_	_	_	_
49	,	_	_	_	_	_	_	_	_
50	indicate	_	_	_	_	_	_	_	_
51	the	_	_	_	_	_	_	_	_
52	involvement	_	_	_	_	_	_	_	_
53	of	_	_	_	_	_	_	_	_
54	immunopathological	_	_	_	_	_	_	_	_
55	complications	_	_	_	_	_	_	_	_
56	.	_	_	_	_	_	_	_	_
57	As	_	_	_	_	_	_	_	BeginSeg=Yes
58	no	_	_	_	_	_	_	_	_
59	effective	_	_	_	_	_	_	_	_
60	treatment	_	_	_	_	_	_	_	_
61	is	_	_	_	_	_	_	_	_
62	currently	_	_	_	_	_	_	_	_
63	available	_	_	_	_	_	_	_	_
64	,	_	_	_	_	_	_	_	_
65	we	_	_	_	_	_	_	_	BeginSeg=Yes
66	propose	_	_	_	_	_	_	_	_
67	'	_	_	_	_	_	_	_	_
68	Primed	_	_	_	_	_	_	_	_
69	'	_	_	_	_	_	_	_	_
70	Mesenchymal	_	_	_	_	_	_	_	_
71	Stem	_	_	_	_	_	_	_	_
72	Cells	_	_	_	_	_	_	_	_
73	(	_	_	_	_	_	_	_	_
74	MSCs	_	_	_	_	_	_	_	_
75	)	_	_	_	_	_	_	_	_
76	as	_	_	_	_	_	_	_	_
77	a	_	_	_	_	_	_	_	_
78	therapeutic	_	_	_	_	_	_	_	_
79	alternative	_	_	_	_	_	_	_	_
80	to	_	_	_	_	_	_	_	BeginSeg=Yes
81	tackle	_	_	_	_	_	_	_	_
82	devastating	_	_	_	_	_	_	_	_
83	epidemic	_	_	_	_	_	_	_	_
84	.	_	_	_	_	_	_	_	_
85	The	_	_	_	_	_	_	_	BeginSeg=Yes
86	individual	_	_	_	_	_	_	_	_
87	response	_	_	_	_	_	_	_	_
88	to	_	_	_	_	_	_	_	_
89	MSCs	_	_	_	_	_	_	_	_
90	treatment	_	_	_	_	_	_	_	_
91	is	_	_	_	_	_	_	_	_
92	heterogeneous	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_
94	During	_	_	_	_	_	_	_	BeginSeg=Yes
95	the	_	_	_	_	_	_	_	_
96	treatment	_	_	_	_	_	_	_	_
97	of	_	_	_	_	_	_	_	_
98	infectious	_	_	_	_	_	_	_	_
99	pathology	_	_	_	_	_	_	_	_
100	,	_	_	_	_	_	_	_	_
101	the	_	_	_	_	_	_	_	_
102	effectiveness	_	_	_	_	_	_	_	_
103	of	_	_	_	_	_	_	_	_
104	the	_	_	_	_	_	_	_	_
105	treatment	_	_	_	_	_	_	_	_
106	may	_	_	_	_	_	_	_	_
107	vary	_	_	_	_	_	_	_	_
108	based	_	_	_	_	_	_	_	BeginSeg=Yes
109	on	_	_	_	_	_	_	_	_
110	the	_	_	_	_	_	_	_	_
111	disease	_	_	_	_	_	_	_	_
112	scenario	_	_	_	_	_	_	_	_
113	.	_	_	_	_	_	_	_	_
114	Interestingly	_	_	_	_	_	_	_	BeginSeg=Yes
115	,	_	_	_	_	_	_	_	_
116	when	_	_	_	_	_	_	_	BeginSeg=Yes
117	transplanted	_	_	_	_	_	_	_	_
118	in	_	_	_	_	_	_	_	_
119	vivo	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	MSCs	_	_	_	_	_	_	_	BeginSeg=Yes
122	are	_	_	_	_	_	_	_	_
123	governed	_	_	_	_	_	_	_	_
124	by	_	_	_	_	_	_	_	_
125	the	_	_	_	_	_	_	_	_
126	locally	_	_	_	_	_	_	_	_
127	regulated	_	_	_	_	_	_	_	_
128	microenvironment	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	suggesting	_	_	_	_	_	_	_	BeginSeg=Yes
131	that	_	_	_	_	_	_	_	BeginSeg=Yes
132	the	_	_	_	_	_	_	_	_
133	restorative	_	_	_	_	_	_	_	_
134	variability	_	_	_	_	_	_	_	_
135	could	_	_	_	_	_	_	_	_
136	be	_	_	_	_	_	_	_	_
137	tailored	_	_	_	_	_	_	_	_
138	by	_	_	_	_	_	_	_	BeginSeg=Yes
139	choosing	_	_	_	_	_	_	_	_
140	a	_	_	_	_	_	_	_	_
141	priming	_	_	_	_	_	_	_	_
142	regimen	_	_	_	_	_	_	_	_
143	to	_	_	_	_	_	_	_	BeginSeg=Yes
144	specifically	_	_	_	_	_	_	_	_
145	correct	_	_	_	_	_	_	_	_
146	a	_	_	_	_	_	_	_	_
147	given	_	_	_	_	_	_	_	_
148	pathology	_	_	_	_	_	_	_	_
149	.	_	_	_	_	_	_	_	_
150	Therefore	_	_	_	_	_	_	_	BeginSeg=Yes
151	,	_	_	_	_	_	_	_	_
152	in	_	_	_	_	_	_	_	_
153	our	_	_	_	_	_	_	_	_
154	opinion	_	_	_	_	_	_	_	_
155	,	_	_	_	_	_	_	_	_
156	the	_	_	_	_	_	_	_	_
157	priming	_	_	_	_	_	_	_	_
158	of	_	_	_	_	_	_	_	_
159	MSCs	_	_	_	_	_	_	_	_
160	could	_	_	_	_	_	_	_	_
161	be	_	_	_	_	_	_	_	_
162	a	_	_	_	_	_	_	_	_
163	novel	_	_	_	_	_	_	_	_
164	approach	_	_	_	_	_	_	_	_
165	to	_	_	_	_	_	_	_	BeginSeg=Yes
166	improve	_	_	_	_	_	_	_	_
167	the	_	_	_	_	_	_	_	_
168	responses	_	_	_	_	_	_	_	_
169	of	_	_	_	_	_	_	_	_
170	COVID19	_	_	_	_	_	_	_	_
171	patients	_	_	_	_	_	_	_	_
172	.	_	_	_	_	_	_	_	_

# newdoc_id = 5dc2712f3e118ac903e215c2e0d155f2ede7ad39
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	pathology	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	2	_	_	_	_	_	_	_	_
5	zoonotic	_	_	_	_	_	_	_	_
6	human	_	_	_	_	_	_	_	_
7	viral	_	_	_	_	_	_	_	_
8	infections	_	_	_	_	_	_	_	_
9	that	_	_	_	_	_	_	_	BeginSeg=Yes
10	recently	_	_	_	_	_	_	_	_
11	emerged	_	_	_	_	_	_	_	_
12	,	_	_	_	_	_	_	_	_
13	severe	_	_	_	_	_	_	_	BeginSeg=Yes
14	acute	_	_	_	_	_	_	_	_
15	respiratory	_	_	_	_	_	_	_	_
16	syndrome	_	_	_	_	_	_	_	_
17	(	_	_	_	_	_	_	_	_
18	SARS	_	_	_	_	_	_	_	_
19	)	_	_	_	_	_	_	_	_
20	due	_	_	_	_	_	_	_	BeginSeg=Yes
21	to	_	_	_	_	_	_	_	_
22	coronavirus	_	_	_	_	_	_	_	_
23	(	_	_	_	_	_	_	_	_
24	SARS	_	_	_	_	_	_	_	_
25	-	_	_	_	_	_	_	_	_
26	CoV	_	_	_	_	_	_	_	_
27	)	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	avian	_	_	_	_	_	_	_	_
30	influenza	_	_	_	_	_	_	_	_
31	A	_	_	_	_	_	_	_	_
32	subtype	_	_	_	_	_	_	_	_
33	H5N1	_	_	_	_	_	_	_	_
34	,	_	_	_	_	_	_	_	_
35	is	_	_	_	_	_	_	_	BeginSeg=Yes
36	reviewed	_	_	_	_	_	_	_	_
37	and	_	_	_	_	_	_	_	_
38	compared	_	_	_	_	_	_	_	_
39	based	_	_	_	_	_	_	_	_
40	on	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	_
42	literature	_	_	_	_	_	_	_	_
43	and	_	_	_	_	_	_	_	_
44	the	_	_	_	_	_	_	_	_
45	cases	_	_	_	_	_	_	_	_
46	examined	_	_	_	_	_	_	_	BeginSeg=Yes
47	by	_	_	_	_	_	_	_	_
48	the	_	_	_	_	_	_	_	_
49	authors	_	_	_	_	_	_	_	_
50	.	_	_	_	_	_	_	_	_
51	Pneumocytes	_	_	_	_	_	_	_	BeginSeg=Yes
52	are	_	_	_	_	_	_	_	_
53	the	_	_	_	_	_	_	_	_
54	primary	_	_	_	_	_	_	_	_
55	target	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	infection	_	_	_	_	_	_	_	_
58	resulting	_	_	_	_	_	_	_	BeginSeg=Yes
59	in	_	_	_	_	_	_	_	_
60	diffuse	_	_	_	_	_	_	_	_
61	alveolar	_	_	_	_	_	_	_	_
62	damage	_	_	_	_	_	_	_	_
63	.	_	_	_	_	_	_	_	_
64	Systemic	_	_	_	_	_	_	_	BeginSeg=Yes
65	cytokine	_	_	_	_	_	_	_	_
66	activation	_	_	_	_	_	_	_	_
67	results	_	_	_	_	_	_	_	_
68	in	_	_	_	_	_	_	_	_
69	hemophagocytic	_	_	_	_	_	_	_	_
70	syndrome	_	_	_	_	_	_	_	_
71	,	_	_	_	_	_	_	_	_
72	lymphoid	_	_	_	_	_	_	_	_
73	depletion	_	_	_	_	_	_	_	_
74	,	_	_	_	_	_	_	_	_
75	and	_	_	_	_	_	_	_	_
76	skeletal	_	_	_	_	_	_	_	_
77	muscle	_	_	_	_	_	_	_	_
78	fiber	_	_	_	_	_	_	_	_
79	necrosis	_	_	_	_	_	_	_	_
80	.	_	_	_	_	_	_	_	_
81	Severe	_	_	_	_	_	_	_	BeginSeg=Yes
82	acute	_	_	_	_	_	_	_	_
83	respiratory	_	_	_	_	_	_	_	_
84	syndrome	_	_	_	_	_	_	_	_
85	induces	_	_	_	_	_	_	_	_
86	a	_	_	_	_	_	_	_	_
87	more	_	_	_	_	_	_	_	_
88	fibrocellular	_	_	_	_	_	_	_	_
89	intra	_	_	_	_	_	_	_	_
90	-	_	_	_	_	_	_	_	_
91	alveolar	_	_	_	_	_	_	_	_
92	organization	_	_	_	_	_	_	_	_
93	with	_	_	_	_	_	_	_	_
94	a	_	_	_	_	_	_	_	_
95	bbronchiolitis	_	_	_	_	_	_	_	_
96	obliterans	_	_	_	_	_	_	_	_
97	organizing	_	_	_	_	_	_	_	BeginSeg=Yes
98	pneumoniaQ	_	_	_	_	_	_	_	_
99	-	_	_	_	_	_	_	_	_
100	like	_	_	_	_	_	_	_	_
101	pattern	_	_	_	_	_	_	_	_
102	and	_	_	_	_	_	_	_	_
103	presence	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	multinucleated	_	_	_	_	_	_	_	_
106	histiocytes	_	_	_	_	_	_	_	_
107	and	_	_	_	_	_	_	_	_
108	pneumocytes	_	_	_	_	_	_	_	_
109	.	_	_	_	_	_	_	_	_
110	H5N1	_	_	_	_	_	_	_	BeginSeg=Yes
111	causes	_	_	_	_	_	_	_	_
112	a	_	_	_	_	_	_	_	_
113	more	_	_	_	_	_	_	_	_
114	fulminant	_	_	_	_	_	_	_	_
115	and	_	_	_	_	_	_	_	_
116	necrotizing	_	_	_	_	_	_	_	_
117	diffuse	_	_	_	_	_	_	_	_
118	alveolar	_	_	_	_	_	_	_	_
119	damage	_	_	_	_	_	_	_	_
120	with	_	_	_	_	_	_	_	_
121	patchy	_	_	_	_	_	_	_	_
122	and	_	_	_	_	_	_	_	_
123	interstitial	_	_	_	_	_	_	_	_
124	paucicellular	_	_	_	_	_	_	_	_
125	fibrosis	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_
127	Severe	_	_	_	_	_	_	_	BeginSeg=Yes
128	acute	_	_	_	_	_	_	_	_
129	respiratory	_	_	_	_	_	_	_	_
130	syndrome	_	_	_	_	_	_	_	_
131	associated	_	_	_	_	_	_	_	_
132	coronavirus	_	_	_	_	_	_	_	_
133	persists	_	_	_	_	_	_	_	_
134	in	_	_	_	_	_	_	_	_
135	the	_	_	_	_	_	_	_	_
136	lung	_	_	_	_	_	_	_	_
137	up	_	_	_	_	_	_	_	_
138	to	_	_	_	_	_	_	_	_
139	the	_	_	_	_	_	_	_	_
140	second	_	_	_	_	_	_	_	_
141	month	_	_	_	_	_	_	_	_
142	,	_	_	_	_	_	_	_	_
143	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
144	H5N1	_	_	_	_	_	_	_	_
145	persists	_	_	_	_	_	_	_	_
146	in	_	_	_	_	_	_	_	_
147	the	_	_	_	_	_	_	_	_
148	lung	_	_	_	_	_	_	_	_
149	up	_	_	_	_	_	_	_	_
150	to	_	_	_	_	_	_	_	_
151	the	_	_	_	_	_	_	_	_
152	third	_	_	_	_	_	_	_	_
153	week	_	_	_	_	_	_	_	_
154	.	_	_	_	_	_	_	_	_
155	Severe	_	_	_	_	_	_	_	BeginSeg=Yes
156	acute	_	_	_	_	_	_	_	_
157	respiratory	_	_	_	_	_	_	_	_
158	syndrome	_	_	_	_	_	_	_	_
159	associated	_	_	_	_	_	_	_	_
160	coronavirus	_	_	_	_	_	_	_	_
161	disseminates	_	_	_	_	_	_	_	_
162	to	_	_	_	_	_	_	_	_
163	blood	_	_	_	_	_	_	_	_
164	,	_	_	_	_	_	_	_	_
165	urine	_	_	_	_	_	_	_	_
166	,	_	_	_	_	_	_	_	_
167	feces	_	_	_	_	_	_	_	_
168	,	_	_	_	_	_	_	_	_
169	gastrointestinal	_	_	_	_	_	_	_	_
170	tract	_	_	_	_	_	_	_	_
171	,	_	_	_	_	_	_	_	_
172	and	_	_	_	_	_	_	_	_
173	liver	_	_	_	_	_	_	_	_
174	.	_	_	_	_	_	_	_	_
175	There	_	_	_	_	_	_	_	BeginSeg=Yes
176	is	_	_	_	_	_	_	_	_
177	recent	_	_	_	_	_	_	_	_
178	report	_	_	_	_	_	_	_	_
179	of	_	_	_	_	_	_	_	_
180	possible	_	_	_	_	_	_	_	_
181	cerebral	_	_	_	_	_	_	_	_
182	involvement	_	_	_	_	_	_	_	_
183	by	_	_	_	_	_	_	_	_
184	H5N1	_	_	_	_	_	_	_	_
185	and	_	_	_	_	_	_	_	_
186	its	_	_	_	_	_	_	_	_
187	isolation	_	_	_	_	_	_	_	_
188	in	_	_	_	_	_	_	_	_
189	the	_	_	_	_	_	_	_	_
190	blood	_	_	_	_	_	_	_	_
191	,	_	_	_	_	_	_	_	_
192	gastrointestinal	_	_	_	_	_	_	_	_
193	tract	_	_	_	_	_	_	_	_
194	,	_	_	_	_	_	_	_	_
195	and	_	_	_	_	_	_	_	_
196	cerebrospinal	_	_	_	_	_	_	_	_
197	fluid	_	_	_	_	_	_	_	_
198	.	_	_	_	_	_	_	_	_
199	More	_	_	_	_	_	_	_	BeginSeg=Yes
200	pathologic	_	_	_	_	_	_	_	_
201	studies	_	_	_	_	_	_	_	_
202	are	_	_	_	_	_	_	_	_
203	urgently	_	_	_	_	_	_	_	_
204	needed	_	_	_	_	_	_	_	_
205	.	_	_	_	_	_	_	_	_

# newdoc_id = 5ddc3c732b0e2be8ffe373107ca6e56e49c4513e
1	A	_	_	_	_	_	_	_	BeginSeg=Yes
2	molecular	_	_	_	_	_	_	_	_
3	docking	_	_	_	_	_	_	_	_
4	study	_	_	_	_	_	_	_	_
5	was	_	_	_	_	_	_	_	_
6	performed	_	_	_	_	_	_	_	_
7	on	_	_	_	_	_	_	_	_
8	several	_	_	_	_	_	_	_	_
9	structurally	_	_	_	_	_	_	_	_
10	diverse	_	_	_	_	_	_	_	_
11	A	_	_	_	_	_	_	_	_
12	2A	_	_	_	_	_	_	_	_
13	AR	_	_	_	_	_	_	_	_
14	antagonists	_	_	_	_	_	_	_	_
15	,	_	_	_	_	_	_	_	_
16	including	_	_	_	_	_	_	_	BeginSeg=Yes
17	xanthines	_	_	_	_	_	_	_	_
18	,	_	_	_	_	_	_	_	_
19	and	_	_	_	_	_	_	_	BeginSeg=Yes
20	non	_	_	_	_	_	_	_	_
21	-	_	_	_	_	_	_	_	_
22	xanthine	_	_	_	_	_	_	_	_
23	type	_	_	_	_	_	_	_	_
24	antagonists	_	_	_	_	_	_	_	_
25	to	_	_	_	_	_	_	_	BeginSeg=Yes
26	investigate	_	_	_	_	_	_	_	_
27	their	_	_	_	_	_	_	_	_
28	binding	_	_	_	_	_	_	_	_
29	modes	_	_	_	_	_	_	_	_
30	with	_	_	_	_	_	_	_	_
31	A	_	_	_	_	_	_	_	_
32	2A	_	_	_	_	_	_	_	_
33	adenosine	_	_	_	_	_	_	_	_
34	receptor	_	_	_	_	_	_	_	_
35	(	_	_	_	_	_	_	_	_
36	AR	_	_	_	_	_	_	_	_
37	)	_	_	_	_	_	_	_	_
38	,	_	_	_	_	_	_	_	_
39	one	_	_	_	_	_	_	_	BeginSeg=Yes
40	of	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	_
42	four	_	_	_	_	_	_	_	_
43	subtypes	_	_	_	_	_	_	_	_
44	of	_	_	_	_	_	_	_	_
45	AR	_	_	_	_	_	_	_	_
46	,	_	_	_	_	_	_	_	_
47	which	_	_	_	_	_	_	_	BeginSeg=Yes
48	is	_	_	_	_	_	_	_	_
49	currently	_	_	_	_	_	_	_	_
50	of	_	_	_	_	_	_	_	_
51	great	_	_	_	_	_	_	_	_
52	interest	_	_	_	_	_	_	_	_
53	as	_	_	_	_	_	_	_	_
54	a	_	_	_	_	_	_	_	_
55	target	_	_	_	_	_	_	_	_
56	for	_	_	_	_	_	_	_	_
57	therapeutic	_	_	_	_	_	_	_	_
58	intervention	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	in	_	_	_	_	_	_	_	_
61	particular	_	_	_	_	_	_	_	_
62	for	_	_	_	_	_	_	_	_
63-64	Parkinson's	_	_	_	_	_	_	_	_
63	Parkinson	_	_	_	_	_	_	_	_
64	's	_	_	_	_	_	_	_	_
65	disease	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	The	_	_	_	_	_	_	_	BeginSeg=Yes
68	high	_	_	_	_	_	_	_	_
69	-	_	_	_	_	_	_	_	_
70	affinity	_	_	_	_	_	_	_	_
71	binding	_	_	_	_	_	_	_	_
72	site	_	_	_	_	_	_	_	_
73	was	_	_	_	_	_	_	_	_
74	found	_	_	_	_	_	_	_	_
75	to	_	_	_	_	_	_	_	_
76	be	_	_	_	_	_	_	_	_
77	a	_	_	_	_	_	_	_	_
78	hydrophobic	_	_	_	_	_	_	_	_
79	pocket	_	_	_	_	_	_	_	_
80	with	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	involvement	_	_	_	_	_	_	_	_
83	of	_	_	_	_	_	_	_	_
84	hydrogen	_	_	_	_	_	_	_	_
85	bonding	_	_	_	_	_	_	_	_
86	interactions	_	_	_	_	_	_	_	_
87	as	_	_	_	_	_	_	_	_
88	well	_	_	_	_	_	_	_	_
89	as	_	_	_	_	_	_	_	_
90	p	_	_	_	_	_	_	_	_
91	-	_	_	_	_	_	_	_	_
92	p	_	_	_	_	_	_	_	_
93	stacking	_	_	_	_	_	_	_	_
94	interactions	_	_	_	_	_	_	_	_
95	with	_	_	_	_	_	_	_	_
96	the	_	_	_	_	_	_	_	_
97	ligands	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	The	_	_	_	_	_	_	_	BeginSeg=Yes
100	detailed	_	_	_	_	_	_	_	_
101	binding	_	_	_	_	_	_	_	_
102	modes	_	_	_	_	_	_	_	_
103	for	_	_	_	_	_	_	_	_
104	both	_	_	_	_	_	_	_	_
105	xanthine	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	non	_	_	_	_	_	_	_	_
108	-	_	_	_	_	_	_	_	_
109	xanthine	_	_	_	_	_	_	_	_
110	type	_	_	_	_	_	_	_	_
111	A	_	_	_	_	_	_	_	_
112	2A	_	_	_	_	_	_	_	_
113	antagonists	_	_	_	_	_	_	_	_
114	were	_	_	_	_	_	_	_	_
115	compared	_	_	_	_	_	_	_	_
116	and	_	_	_	_	_	_	_	BeginSeg=Yes
117	the	_	_	_	_	_	_	_	_
118	essential	_	_	_	_	_	_	_	_
119	features	_	_	_	_	_	_	_	_
120	were	_	_	_	_	_	_	_	_
121	extracted	_	_	_	_	_	_	_	_
122	and	_	_	_	_	_	_	_	BeginSeg=Yes
123	converted	_	_	_	_	_	_	_	_
124	to	_	_	_	_	_	_	_	_
125	database	_	_	_	_	_	_	_	_
126	searchable	_	_	_	_	_	_	_	_
127	queries	_	_	_	_	_	_	_	_
128	for	_	_	_	_	_	_	_	_
129	virtual	_	_	_	_	_	_	_	_
130	screening	_	_	_	_	_	_	_	_
131	study	_	_	_	_	_	_	_	_
132	of	_	_	_	_	_	_	_	_
133	novel	_	_	_	_	_	_	_	_
134	A	_	_	_	_	_	_	_	_
135	2A	_	_	_	_	_	_	_	_
136	AR	_	_	_	_	_	_	_	_
137	antagonists	_	_	_	_	_	_	_	_
138	.	_	_	_	_	_	_	_	_
139	Findings	_	_	_	_	_	_	_	BeginSeg=Yes
140	from	_	_	_	_	_	_	_	_
141	this	_	_	_	_	_	_	_	_
142	study	_	_	_	_	_	_	_	_
143	are	_	_	_	_	_	_	_	_
144	helpful	_	_	_	_	_	_	_	_
145	for	_	_	_	_	_	_	_	_
146	elucidating	_	_	_	_	_	_	_	_
147	the	_	_	_	_	_	_	_	_
148	binding	_	_	_	_	_	_	_	_
149	pattern	_	_	_	_	_	_	_	_
150	of	_	_	_	_	_	_	_	_
151	A	_	_	_	_	_	_	_	_
152	2A	_	_	_	_	_	_	_	_
153	AR	_	_	_	_	_	_	_	_
154	antagonists	_	_	_	_	_	_	_	_
155	and	_	_	_	_	_	_	_	_
156	for	_	_	_	_	_	_	_	_
157	the	_	_	_	_	_	_	_	_
158	design	_	_	_	_	_	_	_	_
159	of	_	_	_	_	_	_	_	_
160	novel	_	_	_	_	_	_	_	_
161	active	_	_	_	_	_	_	_	_
162	ligands	_	_	_	_	_	_	_	_
163	.	_	_	_	_	_	_	_	_

# newdoc_id = 6140703a4f59d2feadfcc54c1185770cbaa651dc
1	As	_	_	_	_	_	_	_	BeginSeg=Yes
2	SARS	_	_	_	_	_	_	_	_
3	-	_	_	_	_	_	_	_	_
4	COV-2	_	_	_	_	_	_	_	_
5	and	_	_	_	_	_	_	_	_
6	the	_	_	_	_	_	_	_	_
7	disease	_	_	_	_	_	_	_	_
8	COVID-19	_	_	_	_	_	_	_	_
9	is	_	_	_	_	_	_	_	_
10	sweeping	_	_	_	_	_	_	_	_
11	through	_	_	_	_	_	_	_	_
12	countries	_	_	_	_	_	_	_	_
13	after	_	_	_	_	_	_	_	_
14	countries	_	_	_	_	_	_	_	_
15	around	_	_	_	_	_	_	_	_
16	the	_	_	_	_	_	_	_	_
17	globe	_	_	_	_	_	_	_	_
18	,	_	_	_	_	_	_	_	_
19	it	_	_	_	_	_	_	_	BeginSeg=Yes
20	is	_	_	_	_	_	_	_	_
21	critical	_	_	_	_	_	_	_	_
22	to	_	_	_	_	_	_	_	_
23	understand	_	_	_	_	_	_	_	_
24	potential	_	_	_	_	_	_	_	_
25	burden	_	_	_	_	_	_	_	_
26	of	_	_	_	_	_	_	_	_
27	a	_	_	_	_	_	_	_	_
28	future	_	_	_	_	_	_	_	_
29	outbreak	_	_	_	_	_	_	_	_
30	in	_	_	_	_	_	_	_	_
31	cities	_	_	_	_	_	_	_	_
32	of	_	_	_	_	_	_	_	_
33	Colombia	_	_	_	_	_	_	_	_
34	.	_	_	_	_	_	_	_	_
35	This	_	_	_	_	_	_	_	BeginSeg=Yes
36	pandemic	_	_	_	_	_	_	_	_
37	has	_	_	_	_	_	_	_	_
38	affected	_	_	_	_	_	_	_	_
39	most	_	_	_	_	_	_	_	_
40	of	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	_
42	countries	_	_	_	_	_	_	_	_
43	in	_	_	_	_	_	_	_	_
44	the	_	_	_	_	_	_	_	_
45	world	_	_	_	_	_	_	_	_
46	because	_	_	_	_	_	_	_	BeginSeg=Yes
47	the	_	_	_	_	_	_	_	_
48	high	_	_	_	_	_	_	_	_
49	global	_	_	_	_	_	_	_	_
50	movement	_	_	_	_	_	_	_	_
51	of	_	_	_	_	_	_	_	_
52	individuals	_	_	_	_	_	_	_	_
53	and	_	_	_	_	_	_	_	_
54	excessive	_	_	_	_	_	_	_	_
55	cost	_	_	_	_	_	_	_	_
56	in	_	_	_	_	_	_	_	_
57	interventions	_	_	_	_	_	_	_	_
58	.	_	_	_	_	_	_	_	_
59	Objective	_	_	_	_	_	_	_	BeginSeg=Yes
60	:	_	_	_	_	_	_	_	_
61	Using	_	_	_	_	_	_	_	BeginSeg=Yes
62	demographic	_	_	_	_	_	_	_	_
63	data	_	_	_	_	_	_	_	_
64	from	_	_	_	_	_	_	_	_
65	city	_	_	_	_	_	_	_	_
66	of	_	_	_	_	_	_	_	_
67	Cali	_	_	_	_	_	_	_	_
68	,	_	_	_	_	_	_	_	_
69	disease	_	_	_	_	_	_	_	_
70	epidemiological	_	_	_	_	_	_	_	_
71	information	_	_	_	_	_	_	_	_
72	from	_	_	_	_	_	_	_	_
73	affected	_	_	_	_	_	_	_	_
74	countries	_	_	_	_	_	_	_	_
75	and	_	_	_	_	_	_	_	_
76	mathematical	_	_	_	_	_	_	_	_
77	models	_	_	_	_	_	_	_	_
78	,	_	_	_	_	_	_	_	_
79	we	_	_	_	_	_	_	_	BeginSeg=Yes
80	estimated	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	rate	_	_	_	_	_	_	_	_
83	of	_	_	_	_	_	_	_	_
84	initial	_	_	_	_	_	_	_	_
85	exponential	_	_	_	_	_	_	_	_
86	growth	_	_	_	_	_	_	_	_
87	of	_	_	_	_	_	_	_	_
88	new	_	_	_	_	_	_	_	_
89	cases	_	_	_	_	_	_	_	_
90	and	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
92	basic	_	_	_	_	_	_	_	_
93	reproductive	_	_	_	_	_	_	_	_
94	rate	_	_	_	_	_	_	_	_
95	for	_	_	_	_	_	_	_	_
96	a	_	_	_	_	_	_	_	_
97	potential	_	_	_	_	_	_	_	_
98	outbreak	_	_	_	_	_	_	_	_
99	in	_	_	_	_	_	_	_	_
100	city	_	_	_	_	_	_	_	_
101	of	_	_	_	_	_	_	_	_
102	Cali	_	_	_	_	_	_	_	_
103	in	_	_	_	_	_	_	_	_
104	Colombia	_	_	_	_	_	_	_	_
105	.	_	_	_	_	_	_	_	_
106	Materials	_	_	_	_	_	_	_	BeginSeg=Yes
107	and	_	_	_	_	_	_	_	_
108	methods	_	_	_	_	_	_	_	_
109	:	_	_	_	_	_	_	_	_
110	We	_	_	_	_	_	_	_	BeginSeg=Yes
111	used	_	_	_	_	_	_	_	_
112	dynamical	_	_	_	_	_	_	_	_
113	models	_	_	_	_	_	_	_	_
114	with	_	_	_	_	_	_	_	_
115	different	_	_	_	_	_	_	_	_
116	modeling	_	_	_	_	_	_	_	_
117	assumptions	_	_	_	_	_	_	_	_
118	such	_	_	_	_	_	_	_	BeginSeg=Yes
119	as	_	_	_	_	_	_	_	_
120	use	_	_	_	_	_	_	_	_
121	of	_	_	_	_	_	_	_	_
122	various	_	_	_	_	_	_	_	_
123	types	_	_	_	_	_	_	_	_
124	of	_	_	_	_	_	_	_	_
125	interventions	_	_	_	_	_	_	_	_
126	and/or	_	_	_	_	_	_	_	_
127	epidemiological	_	_	_	_	_	_	_	_
128	characteristics	_	_	_	_	_	_	_	_
129	to	_	_	_	_	_	_	_	BeginSeg=Yes
130	compare	_	_	_	_	_	_	_	_
131	and	_	_	_	_	_	_	_	_
132	contrast	_	_	_	_	_	_	_	_
133	the	_	_	_	_	_	_	_	_
134	differences	_	_	_	_	_	_	_	_
135	between	_	_	_	_	_	_	_	_
136	Colombian	_	_	_	_	_	_	_	_
137	cities	_	_	_	_	_	_	_	_
138	and	_	_	_	_	_	_	_	_
139	between	_	_	_	_	_	_	_	_
140	Latin	_	_	_	_	_	_	_	_
141	American	_	_	_	_	_	_	_	_
142	countries	_	_	_	_	_	_	_	_
143	.	_	_	_	_	_	_	_	_
144	Results	_	_	_	_	_	_	_	BeginSeg=Yes
145	:	_	_	_	_	_	_	_	_
146	Under	_	_	_	_	_	_	_	BeginSeg=Yes
147	the	_	_	_	_	_	_	_	_
148	assumption	_	_	_	_	_	_	_	_
149	of	_	_	_	_	_	_	_	_
150	homogeneously	_	_	_	_	_	_	_	_
151	mixing	_	_	_	_	_	_	_	_
152	population	_	_	_	_	_	_	_	_
153	and	_	_	_	_	_	_	_	_
154	limited	_	_	_	_	_	_	_	_
155	resources	_	_	_	_	_	_	_	_
156	,	_	_	_	_	_	_	_	_
157	we	_	_	_	_	_	_	_	BeginSeg=Yes
158	predicted	_	_	_	_	_	_	_	_
159	expected	_	_	_	_	_	_	_	_
160	number	_	_	_	_	_	_	_	_
161	of	_	_	_	_	_	_	_	_
162	infected	_	_	_	_	_	_	_	_
163	,	_	_	_	_	_	_	_	_
164	hospitalized	_	_	_	_	_	_	_	_
165	,	_	_	_	_	_	_	_	_
166	in	_	_	_	_	_	_	_	_
167	Intensive	_	_	_	_	_	_	_	_
168	Care	_	_	_	_	_	_	_	_
169	Units	_	_	_	_	_	_	_	_
170	(	_	_	_	_	_	_	_	_
171	ICU	_	_	_	_	_	_	_	_
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174	deaths	_	_	_	_	_	_	_	_
175	during	_	_	_	_	_	_	_	_
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177	potential	_	_	_	_	_	_	_	_
178	COVID-19	_	_	_	_	_	_	_	_
179	outbreak	_	_	_	_	_	_	_	_
180	.	_	_	_	_	_	_	_	_
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182	results	_	_	_	_	_	_	_	_
183	suggest	_	_	_	_	_	_	_	_
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185	on	_	_	_	_	_	_	_	_
186	a	_	_	_	_	_	_	_	_
187	given	_	_	_	_	_	_	_	_
188	day	_	_	_	_	_	_	_	_
189	in	_	_	_	_	_	_	_	_
190	Cali	_	_	_	_	_	_	_	_
191	there	_	_	_	_	_	_	_	_
192	may	_	_	_	_	_	_	_	_
193	be	_	_	_	_	_	_	_	_
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195	to	_	_	_	_	_	_	_	_
196	around	_	_	_	_	_	_	_	_
197	73000	_	_	_	_	_	_	_	_
198	cases	_	_	_	_	_	_	_	_
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200	might	_	_	_	_	_	_	_	_
201	need	_	_	_	_	_	_	_	_
202	hospitalization	_	_	_	_	_	_	_	_
203	under	_	_	_	_	_	_	_	_
204	no	_	_	_	_	_	_	_	_
205	intervention	_	_	_	_	_	_	_	_
206	.	_	_	_	_	_	_	_	_
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208	,	_	_	_	_	_	_	_	_
209	this	_	_	_	_	_	_	_	_
210	number	_	_	_	_	_	_	_	_
211	drastically	_	_	_	_	_	_	_	_
212	reduces	_	_	_	_	_	_	_	_
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214	we	_	_	_	_	_	_	_	_
215	carry	_	_	_	_	_	_	_	_
216	out	_	_	_	_	_	_	_	_
217	only	_	_	_	_	_	_	_	_
218	-	_	_	_	_	_	_	_	_
219	isolation	_	_	_	_	_	_	_	_
220	intervention	_	_	_	_	_	_	_	_
221	(	_	_	_	_	_	_	_	BeginSeg=Yes
222	with	_	_	_	_	_	_	_	_
223	16	_	_	_	_	_	_	_	_
224	days	_	_	_	_	_	_	_	_
225	of	_	_	_	_	_	_	_	_
226	symptomatic	_	_	_	_	_	_	_	_
227	infection	_	_	_	_	_	_	_	_
228	;	_	_	_	_	_	_	_	_
229	~13,000	_	_	_	_	_	_	_	_
230	cases	_	_	_	_	_	_	_	_
231	)	_	_	_	_	_	_	_	_
232	versus	_	_	_	_	_	_	_	BeginSeg=Yes
233	both	_	_	_	_	_	_	_	_
234	quarantining	_	_	_	_	_	_	_	_
235	for	_	_	_	_	_	_	_	_
236	6	_	_	_	_	_	_	_	_
237	days	_	_	_	_	_	_	_	_
238	and	_	_	_	_	_	_	_	_
239	isolation	_	_	_	_	_	_	_	_
240	within	_	_	_	_	_	_	_	_
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242	days	_	_	_	_	_	_	_	_
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244	~3500	_	_	_	_	_	_	_	_
245	cases	_	_	_	_	_	_	_	_
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250	in	_	_	_	_	_	_	_	_
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253	reach	_	_	_	_	_	_	_	_
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255	2	_	_	_	_	_	_	_	_
256	-	_	_	_	_	_	_	_	_
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258	months	_	_	_	_	_	_	_	_
259	.	_	_	_	_	_	_	_	_
260	Conclusions	_	_	_	_	_	_	_	BeginSeg=Yes
261	.	_	_	_	_	_	_	_	_
262	The	_	_	_	_	_	_	_	BeginSeg=Yes
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264	from	_	_	_	_	_	_	_	_
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266	studies	_	_	_	_	_	_	_	_
267	provides	_	_	_	_	_	_	_	_
268	different	_	_	_	_	_	_	_	_
269	scenarios	_	_	_	_	_	_	_	_
270	of	_	_	_	_	_	_	_	_
271	outbreaks	_	_	_	_	_	_	_	_
272	and	_	_	_	_	_	_	_	BeginSeg=Yes
273	can	_	_	_	_	_	_	_	_
274	help	_	_	_	_	_	_	_	_
275	Cali	_	_	_	_	_	_	_	_
276	to	_	_	_	_	_	_	_	_
277	be	_	_	_	_	_	_	_	_
278	better	_	_	_	_	_	_	_	_
279	prepared	_	_	_	_	_	_	_	_
280	during	_	_	_	_	_	_	_	_
281	the	_	_	_	_	_	_	_	_
282	ongoing	_	_	_	_	_	_	_	_
283	COVID-19	_	_	_	_	_	_	_	_
284	outbreak	_	_	_	_	_	_	_	_
285	.	_	_	_	_	_	_	_	_

# newdoc_id = 6170c6d5c7e660f19226bfd026159c4ba6915fda
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2	compared	_	_	_	_	_	_	_	_
3	the	_	_	_	_	_	_	_	_
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7	polymorphisms	_	_	_	_	_	_	_	_
8	in	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	tumor	_	_	_	_	_	_	_	_
11	necrosis	_	_	_	_	_	_	_	_
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14	mannose	_	_	_	_	_	_	_	_
15	-	_	_	_	_	_	_	_	_
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17	lectin	_	_	_	_	_	_	_	_
18	genes	_	_	_	_	_	_	_	_
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20	105	_	_	_	_	_	_	_	_
21	children	_	_	_	_	_	_	_	_
22	and	_	_	_	_	_	_	_	_
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25	with	_	_	_	_	_	_	_	_
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27	infl	_	_	_	_	_	_	_	_
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29	with	_	_	_	_	_	_	_	_
30	US	_	_	_	_	_	_	_	_
31	population	_	_	_	_	_	_	_	_
32	estimates	_	_	_	_	_	_	_	_
33	and	_	_	_	_	_	_	_	BeginSeg=Yes
34	determined	_	_	_	_	_	_	_	_
35	in	_	_	_	_	_	_	_	_
36	subanalyses	_	_	_	_	_	_	_	_
37	whether	_	_	_	_	_	_	_	_
38	these	_	_	_	_	_	_	_	_
39	polymorphisms	_	_	_	_	_	_	_	_
40	were	_	_	_	_	_	_	_	_
41	associated	_	_	_	_	_	_	_	_
42	with	_	_	_	_	_	_	_	_
43	sudden	_	_	_	_	_	_	_	_
44	death	_	_	_	_	_	_	_	_
45	and	_	_	_	_	_	_	_	_
46	bacterial	_	_	_	_	_	_	_	_
47	co	_	_	_	_	_	_	_	_
48	-	_	_	_	_	_	_	_	_
49	infection	_	_	_	_	_	_	_	_
50	among	_	_	_	_	_	_	_	_
51	persons	_	_	_	_	_	_	_	_
52	with	_	_	_	_	_	_	_	_
53	fatal	_	_	_	_	_	_	_	_
54	infl	_	_	_	_	_	_	_	_
55	uenza	_	_	_	_	_	_	_	_
56	.	_	_	_	_	_	_	_	_
57	No	_	_	_	_	_	_	_	BeginSeg=Yes
58	differences	_	_	_	_	_	_	_	_
59	were	_	_	_	_	_	_	_	_
60	observed	_	_	_	_	_	_	_	_
61	in	_	_	_	_	_	_	_	_
62	genotype	_	_	_	_	_	_	_	_
63	prevalence	_	_	_	_	_	_	_	_
64	or	_	_	_	_	_	_	_	_
65	minor	_	_	_	_	_	_	_	_
66	allele	_	_	_	_	_	_	_	_
67	frequencies	_	_	_	_	_	_	_	_
68	between	_	_	_	_	_	_	_	_
69	persons	_	_	_	_	_	_	_	_
70	with	_	_	_	_	_	_	_	_
71	fatal	_	_	_	_	_	_	_	_
72	infl	_	_	_	_	_	_	_	_
73	uenza	_	_	_	_	_	_	_	_
74	and	_	_	_	_	_	_	_	_
75	the	_	_	_	_	_	_	_	_
76	reference	_	_	_	_	_	_	_	_
77	sample	_	_	_	_	_	_	_	_
78	.	_	_	_	_	_	_	_	_
79	Fatal	_	_	_	_	_	_	_	BeginSeg=Yes
80	cases	_	_	_	_	_	_	_	_
81	with	_	_	_	_	_	_	_	_
82	low	_	_	_	_	_	_	_	_
83	-	_	_	_	_	_	_	_	_
84	producing	_	_	_	_	_	_	_	_
85	MBL2	_	_	_	_	_	_	_	_
86	genotypes	_	_	_	_	_	_	_	_
87	had	_	_	_	_	_	_	_	_
88	a	_	_	_	_	_	_	_	_
89	7-fold	_	_	_	_	_	_	_	_
90	increased	_	_	_	_	_	_	_	_
91	risk	_	_	_	_	_	_	_	_
92	for	_	_	_	_	_	_	_	_
93	invasive	_	_	_	_	_	_	_	_
94	methicillin	_	_	_	_	_	_	_	_
95	-	_	_	_	_	_	_	_	_
96	resistant	_	_	_	_	_	_	_	_
97	Staphylococcus	_	_	_	_	_	_	_	_
98	aureus	_	_	_	_	_	_	_	_
99	(	_	_	_	_	_	_	_	_
100	MRSA	_	_	_	_	_	_	_	_
101	)	_	_	_	_	_	_	_	_
102	co	_	_	_	_	_	_	_	_
103	-	_	_	_	_	_	_	_	_
104	infection	_	_	_	_	_	_	_	_
105	compared	_	_	_	_	_	_	_	BeginSeg=Yes
106	with	_	_	_	_	_	_	_	_
107	fatal	_	_	_	_	_	_	_	_
108	cases	_	_	_	_	_	_	_	_
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110	highand	_	_	_	_	_	_	_	_
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112	-	_	_	_	_	_	_	_	_
113	producing	_	_	_	_	_	_	_	_
114	MBL2	_	_	_	_	_	_	_	_
115	genotypes	_	_	_	_	_	_	_	_
116	(	_	_	_	_	_	_	_	BeginSeg=Yes
117	odds	_	_	_	_	_	_	_	_
118	ratio	_	_	_	_	_	_	_	_
119	7.1	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	95	_	_	_	_	_	_	_	_
122	%	_	_	_	_	_	_	_	_
123	confi	_	_	_	_	_	_	_	_
124	dence	_	_	_	_	_	_	_	_
125	interval	_	_	_	_	_	_	_	_
126	1.6	_	_	_	_	_	_	_	_
127	-	_	_	_	_	_	_	_	_
128	32.1	_	_	_	_	_	_	_	_
129	)	_	_	_	_	_	_	_	_
130	.	_	_	_	_	_	_	_	_
131	Limited	_	_	_	_	_	_	_	BeginSeg=Yes
132	analysis	_	_	_	_	_	_	_	_
133	of	_	_	_	_	_	_	_	_
134	2	_	_	_	_	_	_	_	_
135	genes	_	_	_	_	_	_	_	_
136	important	_	_	_	_	_	_	_	_
137	to	_	_	_	_	_	_	_	_
138	the	_	_	_	_	_	_	_	_
139	innate	_	_	_	_	_	_	_	_
140	immune	_	_	_	_	_	_	_	_
141	response	_	_	_	_	_	_	_	_
142	found	_	_	_	_	_	_	_	_
143	no	_	_	_	_	_	_	_	_
144	association	_	_	_	_	_	_	_	_
145	between	_	_	_	_	_	_	_	_
146	genetic	_	_	_	_	_	_	_	_
147	variants	_	_	_	_	_	_	_	_
148	and	_	_	_	_	_	_	_	_
149	fatal	_	_	_	_	_	_	_	_
150	infl	_	_	_	_	_	_	_	_
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152	infection	_	_	_	_	_	_	_	_
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155	children	_	_	_	_	_	_	_	_
156	and	_	_	_	_	_	_	_	_
157	young	_	_	_	_	_	_	_	_
158	adults	_	_	_	_	_	_	_	_
159	who	_	_	_	_	_	_	_	BeginSeg=Yes
160	died	_	_	_	_	_	_	_	_
161	of	_	_	_	_	_	_	_	_
162	infl	_	_	_	_	_	_	_	_
163	uenza	_	_	_	_	_	_	_	_
164	,	_	_	_	_	_	_	_	_
165	low	_	_	_	_	_	_	_	BeginSeg=Yes
166	-	_	_	_	_	_	_	_	_
167	producing	_	_	_	_	_	_	_	_
168	MBL2	_	_	_	_	_	_	_	_
169	genotypes	_	_	_	_	_	_	_	_
170	may	_	_	_	_	_	_	_	_
171	have	_	_	_	_	_	_	_	_
172	increased	_	_	_	_	_	_	_	_
173	risk	_	_	_	_	_	_	_	_
174	for	_	_	_	_	_	_	_	_
175	MRSA	_	_	_	_	_	_	_	_
176	co	_	_	_	_	_	_	_	_
177	-	_	_	_	_	_	_	_	_
178	infection	_	_	_	_	_	_	_	_
179	.	_	_	_	_	_	_	_	_

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2	contact	_	_	_	_	_	_	_	_
3	tracing	_	_	_	_	_	_	_	_
4	applications	_	_	_	_	_	_	_	_
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7	developed	_	_	_	_	_	_	_	_
8	by	_	_	_	_	_	_	_	_
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11	the	_	_	_	_	_	_	_	_
12	world	_	_	_	_	_	_	_	_
13	,	_	_	_	_	_	_	_	_
14	to	_	_	_	_	_	_	_	BeginSeg=Yes
15	track	_	_	_	_	_	_	_	_
16	and	_	_	_	_	_	_	_	_
17	trace	_	_	_	_	_	_	_	_
18	contacts	_	_	_	_	_	_	_	_
19	.	_	_	_	_	_	_	_	_
20	With	_	_	_	_	_	_	_	BeginSeg=Yes
21	little	_	_	_	_	_	_	_	_
22	evidence	_	_	_	_	_	_	_	_
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27	forced	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	made	_	_	_	_	_	_	_	_
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37	step	_	_	_	_	_	_	_	_
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39	pandemic	_	_	_	_	_	_	_	_
40	control	_	_	_	_	_	_	_	_
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44	briefly	_	_	_	_	_	_	_	_
45	if	_	_	_	_	_	_	_	BeginSeg=Yes
46	contact	_	_	_	_	_	_	_	_
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50	successful	_	_	_	_	_	_	_	_
51	in	_	_	_	_	_	_	_	_
52	the	_	_	_	_	_	_	_	_
53	control	_	_	_	_	_	_	_	_
54	of	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	Corona	_	_	_	_	_	_	_	_
57	virus	_	_	_	_	_	_	_	_
58	pandemic	_	_	_	_	_	_	_	_
59	or	_	_	_	_	_	_	_	BeginSeg=Yes
60	is	_	_	_	_	_	_	_	_
61	it	_	_	_	_	_	_	_	_
62	just	_	_	_	_	_	_	_	_
63	a	_	_	_	_	_	_	_	_
64	tool	_	_	_	_	_	_	_	_
65	governments	_	_	_	_	_	_	_	BeginSeg=Yes
66	are	_	_	_	_	_	_	_	_
67	using	_	_	_	_	_	_	_	_
68	to	_	_	_	_	_	_	_	BeginSeg=Yes
69	cover	_	_	_	_	_	_	_	_
70	their	_	_	_	_	_	_	_	_
71	helplessness	_	_	_	_	_	_	_	_
72	.	_	_	_	_	_	_	_	_

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2	hundred	_	_	_	_	_	_	_	_
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5	-	_	_	_	_	_	_	_	_
6	eight	_	_	_	_	_	_	_	_
7	ganglia	_	_	_	_	_	_	_	_
8	from	_	_	_	_	_	_	_	_
9	54	_	_	_	_	_	_	_	_
10	cattle	_	_	_	_	_	_	_	_
11	aged	_	_	_	_	_	_	_	BeginSeg=Yes
12	10	_	_	_	_	_	_	_	_
13	days	_	_	_	_	_	_	_	_
14	to	_	_	_	_	_	_	_	_
15	10	_	_	_	_	_	_	_	_
16	years	_	_	_	_	_	_	_	_
17	were	_	_	_	_	_	_	_	BeginSeg=Yes
18	examined	_	_	_	_	_	_	_	_
19	microscopically	_	_	_	_	_	_	_	_
20	.	_	_	_	_	_	_	_	_
21	Samples	_	_	_	_	_	_	_	BeginSeg=Yes
22	from	_	_	_	_	_	_	_	_
23	six	_	_	_	_	_	_	_	_
24	autonomic	_	_	_	_	_	_	_	_
25	ganglia	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	one	_	_	_	_	_	_	_	_
28	sensory	_	_	_	_	_	_	_	_
29	ganglion	_	_	_	_	_	_	_	_
30	were	_	_	_	_	_	_	_	_
31	represented	_	_	_	_	_	_	_	_
32	.	_	_	_	_	_	_	_	_
33	Thirteen	_	_	_	_	_	_	_	BeginSeg=Yes
34	animals	_	_	_	_	_	_	_	_
35	were	_	_	_	_	_	_	_	_
36	clinically	_	_	_	_	_	_	_	_
37	normal	_	_	_	_	_	_	_	_
38	and	_	_	_	_	_	_	_	BeginSeg=Yes
39	41	_	_	_	_	_	_	_	_
40	were	_	_	_	_	_	_	_	_
41	submitted	_	_	_	_	_	_	_	_
42	for	_	_	_	_	_	_	_	_
43	post	_	_	_	_	_	_	_	_
44	-	_	_	_	_	_	_	_	_
45	mortem	_	_	_	_	_	_	_	_
46	examination	_	_	_	_	_	_	_	_
47	.	_	_	_	_	_	_	_	_
48	Neuronal	_	_	_	_	_	_	_	BeginSeg=Yes
49	vacuolation	_	_	_	_	_	_	_	_
50	,	_	_	_	_	_	_	_	_
51	spheroid	_	_	_	_	_	_	_	_
52	formation	_	_	_	_	_	_	_	_
53	,	_	_	_	_	_	_	_	_
54	lipofuscin	_	_	_	_	_	_	_	_
55	accumulation	_	_	_	_	_	_	_	_
56	and	_	_	_	_	_	_	_	_
57	central	_	_	_	_	_	_	_	_
58	chromatolysis	_	_	_	_	_	_	_	_
59	were	_	_	_	_	_	_	_	_
60	observed	_	_	_	_	_	_	_	_
61	sporadically	_	_	_	_	_	_	_	_
62	and	_	_	_	_	_	_	_	BeginSeg=Yes
63	were	_	_	_	_	_	_	_	_
64	of	_	_	_	_	_	_	_	_
65	varying	_	_	_	_	_	_	_	_
66	magnitude	_	_	_	_	_	_	_	_
67	.	_	_	_	_	_	_	_	_
68	Neuronal	_	_	_	_	_	_	_	BeginSeg=Yes
69	vacuolation	_	_	_	_	_	_	_	_
70	and	_	_	_	_	_	_	_	_
71	spheroid	_	_	_	_	_	_	_	_
72	formation	_	_	_	_	_	_	_	_
73	were	_	_	_	_	_	_	_	_
74	not	_	_	_	_	_	_	_	_
75	age	_	_	_	_	_	_	_	_
76	-	_	_	_	_	_	_	_	_
77	related	_	_	_	_	_	_	_	_
78	changes	_	_	_	_	_	_	_	_
79	,	_	_	_	_	_	_	_	_
80	while	_	_	_	_	_	_	_	BeginSeg=Yes
81	lipofuscin	_	_	_	_	_	_	_	_
82	accumulation	_	_	_	_	_	_	_	_
83	was	_	_	_	_	_	_	_	_
84	more	_	_	_	_	_	_	_	_
85	common	_	_	_	_	_	_	_	_
86	in	_	_	_	_	_	_	_	_
87	older	_	_	_	_	_	_	_	_
88	animals	_	_	_	_	_	_	_	_
89	and	_	_	_	_	_	_	_	BeginSeg=Yes
90	central	_	_	_	_	_	_	_	_
91	chromatolysis	_	_	_	_	_	_	_	_
92	was	_	_	_	_	_	_	_	_
93	more	_	_	_	_	_	_	_	_
94	common	_	_	_	_	_	_	_	_
95	in	_	_	_	_	_	_	_	_
96	younger	_	_	_	_	_	_	_	_
97	cattle	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	Nonsuppurative	_	_	_	_	_	_	_	BeginSeg=Yes
100	inflammation	_	_	_	_	_	_	_	_
101	and	_	_	_	_	_	_	_	_
102	neuronophagia	_	_	_	_	_	_	_	_
103	were	_	_	_	_	_	_	_	_
104	also	_	_	_	_	_	_	_	_
105	common	_	_	_	_	_	_	_	_
106	findings	_	_	_	_	_	_	_	_
107	(	_	_	_	_	_	_	_	BeginSeg=Yes
108	23	_	_	_	_	_	_	_	_
109	out	_	_	_	_	_	_	_	_
110	of	_	_	_	_	_	_	_	_
111	54	_	_	_	_	_	_	_	_
112	animals	_	_	_	_	_	_	_	_
113	,	_	_	_	_	_	_	_	_
114	42.6	_	_	_	_	_	_	_	_
115	%	_	_	_	_	_	_	_	_
116	)	_	_	_	_	_	_	_	_
117	in	_	_	_	_	_	_	_	BeginSeg=Yes
118	autonomic	_	_	_	_	_	_	_	_
119	ganglia	_	_	_	_	_	_	_	_
120	that	_	_	_	_	_	_	_	BeginSeg=Yes
121	did	_	_	_	_	_	_	_	_
122	not	_	_	_	_	_	_	_	_
123	contain	_	_	_	_	_	_	_	_
124	herpesvirus	_	_	_	_	_	_	_	_
125	DNA	_	_	_	_	_	_	_	_
126	as	_	_	_	_	_	_	_	BeginSeg=Yes
127	determined	_	_	_	_	_	_	_	_
128	by	_	_	_	_	_	_	_	_
129	polymerase	_	_	_	_	_	_	_	_
130	chain	_	_	_	_	_	_	_	_
131	reaction	_	_	_	_	_	_	_	_
132	.	_	_	_	_	_	_	_	_
133	Renaut	_	_	_	_	_	_	_	BeginSeg=Yes
134	bodies	_	_	_	_	_	_	_	_
135	,	_	_	_	_	_	_	_	_
136	features	_	_	_	_	_	_	_	_
137	of	_	_	_	_	_	_	_	_
138	peripheral	_	_	_	_	_	_	_	_
139	nerves	_	_	_	_	_	_	_	_
140	,	_	_	_	_	_	_	_	_
141	were	_	_	_	_	_	_	_	_
142	most	_	_	_	_	_	_	_	_
143	commonly	_	_	_	_	_	_	_	_
144	noted	_	_	_	_	_	_	_	_
145	in	_	_	_	_	_	_	_	_
146	the	_	_	_	_	_	_	_	_
147	vagus	_	_	_	_	_	_	_	_
148	.	_	_	_	_	_	_	_	_
149	None	_	_	_	_	_	_	_	BeginSeg=Yes
150	of	_	_	_	_	_	_	_	_
151	the	_	_	_	_	_	_	_	_
152	histopathological	_	_	_	_	_	_	_	_
153	findings	_	_	_	_	_	_	_	_
154	were	_	_	_	_	_	_	_	_
155	related	_	_	_	_	_	_	_	_
156	to	_	_	_	_	_	_	_	_
157	any	_	_	_	_	_	_	_	_
158	particular	_	_	_	_	_	_	_	_
159	disease	_	_	_	_	_	_	_	_
160	in	_	_	_	_	_	_	_	BeginSeg=Yes
161	which	_	_	_	_	_	_	_	_
162	loss	_	_	_	_	_	_	_	_
163	of	_	_	_	_	_	_	_	_
164	autonomic	_	_	_	_	_	_	_	_
165	nervous	_	_	_	_	_	_	_	_
166	system	_	_	_	_	_	_	_	_
167	function	_	_	_	_	_	_	_	_
168	might	_	_	_	_	_	_	_	_
169	be	_	_	_	_	_	_	_	_
170	expected	_	_	_	_	_	_	_	_
171	.	_	_	_	_	_	_	_	_
172	Furthermore	_	_	_	_	_	_	_	BeginSeg=Yes
173	,	_	_	_	_	_	_	_	_
174	all	_	_	_	_	_	_	_	_
175	changes	_	_	_	_	_	_	_	_
176	were	_	_	_	_	_	_	_	_
177	as	_	_	_	_	_	_	_	_
178	common	_	_	_	_	_	_	_	_
179	in	_	_	_	_	_	_	_	_
180	clinically	_	_	_	_	_	_	_	_
181	normal	_	_	_	_	_	_	_	_
182	animals	_	_	_	_	_	_	_	_
183	as	_	_	_	_	_	_	_	_
184	in	_	_	_	_	_	_	_	_
185	animals	_	_	_	_	_	_	_	_
186	with	_	_	_	_	_	_	_	_
187	disease	_	_	_	_	_	_	_	_
188	.	_	_	_	_	_	_	_	_

# newdoc_id = 63751161a879bf0d284633c4364091ae729003ec
1	Globalization	_	_	_	_	_	_	_	BeginSeg=Yes
2	may	_	_	_	_	_	_	_	_
3	be	_	_	_	_	_	_	_	_
4	viewed	_	_	_	_	_	_	_	_
5	as	_	_	_	_	_	_	_	_
6	the	_	_	_	_	_	_	_	_
7	growing	_	_	_	_	_	_	_	_
8	interdependence	_	_	_	_	_	_	_	_
9	of	_	_	_	_	_	_	_	_
10	countries	_	_	_	_	_	_	_	_
11	worldwide	_	_	_	_	_	_	_	_
12	through	_	_	_	_	_	_	_	_
13	the	_	_	_	_	_	_	_	_
14	increasing	_	_	_	_	_	_	_	_
15	volume	_	_	_	_	_	_	_	_
16	and	_	_	_	_	_	_	_	_
17	variety	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	cross	_	_	_	_	_	_	_	_
20	-	_	_	_	_	_	_	_	_
21	border	_	_	_	_	_	_	_	_
22	transactions	_	_	_	_	_	_	_	_
23	in	_	_	_	_	_	_	_	_
24	goods	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	services	_	_	_	_	_	_	_	_
27	,	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	also	_	_	_	_	_	_	_	_
30	through	_	_	_	_	_	_	_	_
31	the	_	_	_	_	_	_	_	_
32	more	_	_	_	_	_	_	_	_
33	rapid	_	_	_	_	_	_	_	_
34	and	_	_	_	_	_	_	_	_
35	widespread	_	_	_	_	_	_	_	_
36	diffusion	_	_	_	_	_	_	_	_
37	of	_	_	_	_	_	_	_	_
38	technology	_	_	_	_	_	_	_	_
39	.	_	_	_	_	_	_	_	_
40	Globalization	_	_	_	_	_	_	_	BeginSeg=Yes
41	is	_	_	_	_	_	_	_	_
42	not	_	_	_	_	_	_	_	_
43	just	_	_	_	_	_	_	_	_
44	an	_	_	_	_	_	_	_	_
45	economic	_	_	_	_	_	_	_	_
46	phenomenon	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	although	_	_	_	_	_	_	_	BeginSeg=Yes
49	it	_	_	_	_	_	_	_	_
50	is	_	_	_	_	_	_	_	_
51	frequently	_	_	_	_	_	_	_	_
52	described	_	_	_	_	_	_	_	_
53	as	_	_	_	_	_	_	_	_
54	such	_	_	_	_	_	_	_	_
55	,	_	_	_	_	_	_	_	_
56	but	_	_	_	_	_	_	_	BeginSeg=Yes
57	includes	_	_	_	_	_	_	_	_
58	commerce	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	disease	_	_	_	_	_	_	_	_
61	and	_	_	_	_	_	_	_	_
62	travel	_	_	_	_	_	_	_	_
63	,	_	_	_	_	_	_	_	_
64	and	_	_	_	_	_	_	_	_
65	immigration	_	_	_	_	_	_	_	_
66	,	_	_	_	_	_	_	_	_
67	and	_	_	_	_	_	_	_	BeginSeg=Yes
68	as	_	_	_	_	_	_	_	_
69	such	_	_	_	_	_	_	_	_
70	it	_	_	_	_	_	_	_	_
71	affects	_	_	_	_	_	_	_	_
72	blood	_	_	_	_	_	_	_	_
73	safety	_	_	_	_	_	_	_	_
74	and	_	_	_	_	_	_	_	_
75	supply	_	_	_	_	_	_	_	_
76	in	_	_	_	_	_	_	_	_
77	various	_	_	_	_	_	_	_	_
78	ways	_	_	_	_	_	_	_	_
79	.	_	_	_	_	_	_	_	_
80	The	_	_	_	_	_	_	_	BeginSeg=Yes
81	relatively	_	_	_	_	_	_	_	_
82	short	_	_	_	_	_	_	_	_
83	travel	_	_	_	_	_	_	_	_
84	times	_	_	_	_	_	_	_	_
85	offered	_	_	_	_	_	_	_	BeginSeg=Yes
86	by	_	_	_	_	_	_	_	_
87	modern	_	_	_	_	_	_	_	_
88	aviation	_	_	_	_	_	_	_	_
89	can	_	_	_	_	_	_	_	BeginSeg=Yes
90	result	_	_	_	_	_	_	_	_
91	in	_	_	_	_	_	_	_	_
92	the	_	_	_	_	_	_	_	_
93	rapid	_	_	_	_	_	_	_	_
94	spread	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	blood	_	_	_	_	_	_	_	_
97	-	_	_	_	_	_	_	_	_
98	borne	_	_	_	_	_	_	_	_
99	pathogens	_	_	_	_	_	_	_	_
100	before	_	_	_	_	_	_	_	BeginSeg=Yes
101	measures	_	_	_	_	_	_	_	_
102	to	_	_	_	_	_	_	_	BeginSeg=Yes
103	counteract	_	_	_	_	_	_	_	_
104	transmission	_	_	_	_	_	_	_	_
105	can	_	_	_	_	_	_	_	BeginSeg=Yes
106	be	_	_	_	_	_	_	_	_
107	put	_	_	_	_	_	_	_	_
108	in	_	_	_	_	_	_	_	_
109	place	_	_	_	_	_	_	_	_
110	;	_	_	_	_	_	_	_	_
111	this	_	_	_	_	_	_	_	BeginSeg=Yes
112	would	_	_	_	_	_	_	_	_
113	have	_	_	_	_	_	_	_	_
114	happened	_	_	_	_	_	_	_	_
115	with	_	_	_	_	_	_	_	_
116	SARS	_	_	_	_	_	_	_	_
117	if	_	_	_	_	_	_	_	BeginSeg=Yes
118	the	_	_	_	_	_	_	_	_
119	basic	_	_	_	_	_	_	_	_
120	life	_	_	_	_	_	_	_	_
121	cycle	_	_	_	_	_	_	_	_
122	of	_	_	_	_	_	_	_	_
123	the	_	_	_	_	_	_	_	_
124	SARS	_	_	_	_	_	_	_	_
125	virus	_	_	_	_	_	_	_	_
126	did	_	_	_	_	_	_	_	_
127	not	_	_	_	_	_	_	_	_
128	include	_	_	_	_	_	_	_	_
129	an	_	_	_	_	_	_	_	_
130	asymptomatic	_	_	_	_	_	_	_	_
131	viraemia	_	_	_	_	_	_	_	_
132	.	_	_	_	_	_	_	_	_
133	This	_	_	_	_	_	_	_	BeginSeg=Yes
134	risk	_	_	_	_	_	_	_	_
135	can	_	_	_	_	_	_	_	_
136	be	_	_	_	_	_	_	_	_
137	amplified	_	_	_	_	_	_	_	_
138	by	_	_	_	_	_	_	_	_
139	ecological	_	_	_	_	_	_	_	_
140	factors	_	_	_	_	_	_	_	_
141	which	_	_	_	_	_	_	_	BeginSeg=Yes
142	effect	_	_	_	_	_	_	_	_
143	the	_	_	_	_	_	_	_	_
144	spread	_	_	_	_	_	_	_	_
145	of	_	_	_	_	_	_	_	_
146	these	_	_	_	_	_	_	_	_
147	pathogens	_	_	_	_	_	_	_	_
148	once	_	_	_	_	_	_	_	BeginSeg=Yes
149	they	_	_	_	_	_	_	_	_
150	are	_	_	_	_	_	_	_	_
151	transferred	_	_	_	_	_	_	_	_
152	to	_	_	_	_	_	_	_	_
153	a	_	_	_	_	_	_	_	_
154	naïve	_	_	_	_	_	_	_	_
155	ecosystem	_	_	_	_	_	_	_	_
156	,	_	_	_	_	_	_	_	_
157	as	_	_	_	_	_	_	_	BeginSeg=Yes
158	happened	_	_	_	_	_	_	_	_
159	with	_	_	_	_	_	_	_	_
160	West	_	_	_	_	_	_	_	_
161	Nile	_	_	_	_	_	_	_	_
162	virus	_	_	_	_	_	_	_	_
163	(	_	_	_	_	_	_	_	_
164	WNV	_	_	_	_	_	_	_	_
165	)	_	_	_	_	_	_	_	_
166	in	_	_	_	_	_	_	_	_
167	North	_	_	_	_	_	_	_	_
168	America	_	_	_	_	_	_	_	_
169	.	_	_	_	_	_	_	_	_
170	The	_	_	_	_	_	_	_	BeginSeg=Yes
171	rationalization	_	_	_	_	_	_	_	_
172	and	_	_	_	_	_	_	_	_
173	contraction	_	_	_	_	_	_	_	_
174	of	_	_	_	_	_	_	_	_
175	the	_	_	_	_	_	_	_	_
176	plasma	_	_	_	_	_	_	_	_
177	products	_	_	_	_	_	_	_	_
178	industry	_	_	_	_	_	_	_	_
179	may	_	_	_	_	_	_	_	_
180	be	_	_	_	_	_	_	_	_
181	viewed	_	_	_	_	_	_	_	_
182	as	_	_	_	_	_	_	_	_
183	one	_	_	_	_	_	_	_	_
184	aspect	_	_	_	_	_	_	_	_
185	of	_	_	_	_	_	_	_	_
186	globalization	_	_	_	_	_	_	_	_
187	imposed	_	_	_	_	_	_	_	BeginSeg=Yes
188	by	_	_	_	_	_	_	_	_
189	the	_	_	_	_	_	_	_	_
190	remorseless	_	_	_	_	_	_	_	_
191	inevitability	_	_	_	_	_	_	_	_
192	of	_	_	_	_	_	_	_	_
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142	a	_	_	_	_	_	_	_	_
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161	neoantigens	_	_	_	_	_	_	_	_
162	.	_	_	_	_	_	_	_	_

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182	mAbs	_	_	_	_	_	_	_	_
183	,	_	_	_	_	_	_	_	_
184	particularly	_	_	_	_	_	_	_	_
185	in	_	_	_	_	_	_	_	_
186	CDR-1	_	_	_	_	_	_	_	_
187	and	_	_	_	_	_	_	_	_
188	CDR-2	_	_	_	_	_	_	_	_
189	.	_	_	_	_	_	_	_	_
190	The	_	_	_	_	_	_	_	BeginSeg=Yes
191	results	_	_	_	_	_	_	_	_
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194	optimization	_	_	_	_	_	_	_	_
195	of	_	_	_	_	_	_	_	_
196	murine	_	_	_	_	_	_	_	_
197	mAbs	_	_	_	_	_	_	_	_
198	for	_	_	_	_	_	_	_	_
199	neutralization	_	_	_	_	_	_	_	_
200	of	_	_	_	_	_	_	_	_
201	SARS	_	_	_	_	_	_	_	_
202	-	_	_	_	_	_	_	_	_
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204	infection	_	_	_	_	_	_	_	_
205	will	_	_	_	_	_	_	_	_
206	likely	_	_	_	_	_	_	_	_
207	be	_	_	_	_	_	_	_	_
208	possible	_	_	_	_	_	_	_	_
209	,	_	_	_	_	_	_	_	_
210	and	_	_	_	_	_	_	_	BeginSeg=Yes
211	will	_	_	_	_	_	_	_	_
212	aid	_	_	_	_	_	_	_	_
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214	the	_	_	_	_	_	_	_	_
215	development	_	_	_	_	_	_	_	_
216	of	_	_	_	_	_	_	_	_
217	diagnostic	_	_	_	_	_	_	_	_
218	tools	_	_	_	_	_	_	_	_
219	and	_	_	_	_	_	_	_	_
220	passive	_	_	_	_	_	_	_	_
221	treatments	_	_	_	_	_	_	_	_
222	for	_	_	_	_	_	_	_	_
223	SARS	_	_	_	_	_	_	_	_
224	-	_	_	_	_	_	_	_	_
225	CoV	_	_	_	_	_	_	_	_
226	infection	_	_	_	_	_	_	_	_
227	.	_	_	_	_	_	_	_	_

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2	growing	_	_	_	_	_	_	_	_
3	evidence	_	_	_	_	_	_	_	_
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5	inhalation	_	_	_	_	_	_	_	_
6	of	_	_	_	_	_	_	_	_
7	small	_	_	_	_	_	_	_	_
8	infectious	_	_	_	_	_	_	_	_
9	particles	_	_	_	_	_	_	_	_
10	as	_	_	_	_	_	_	_	_
11	an	_	_	_	_	_	_	_	_
12	important	_	_	_	_	_	_	_	_
13	mode	_	_	_	_	_	_	_	_
14	of	_	_	_	_	_	_	_	_
15	transmission	_	_	_	_	_	_	_	_
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17	SARS	_	_	_	_	_	_	_	_
18	-	_	_	_	_	_	_	_	_
19	CoV-2	_	_	_	_	_	_	_	_
20	,	_	_	_	_	_	_	_	_
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22	risk	_	_	_	_	_	_	_	_
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24	should	_	_	_	_	_	_	_	_
25	focus	_	_	_	_	_	_	_	_
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27	eliminating	_	_	_	_	_	_	_	_
28	or	_	_	_	_	_	_	_	_
29	minimizing	_	_	_	_	_	_	_	_
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31	exposures	_	_	_	_	_	_	_	_
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33	applying	_	_	_	_	_	_	_	_
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36	of	_	_	_	_	_	_	_	_
37	controls	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
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41	a	_	_	_	_	_	_	_	_
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47	-	_	_	_	_	_	_	_	_
48	transmissible	_	_	_	_	_	_	_	_
49	infectious	_	_	_	_	_	_	_	_
50	disease	_	_	_	_	_	_	_	_
51	pandemic	_	_	_	_	_	_	_	_
52	planning	_	_	_	_	_	_	_	_
53	to	_	_	_	_	_	_	_	BeginSeg=Yes
54	encourage	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
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59	and	_	_	_	_	_	_	_	_
60	pathway	_	_	_	_	_	_	_	_
61	controls	_	_	_	_	_	_	_	_
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63	receptor	_	_	_	_	_	_	_	_
64	controls	_	_	_	_	_	_	_	_
65	(	_	_	_	_	_	_	_	BeginSeg=Yes
66	personal	_	_	_	_	_	_	_	_
67	protective	_	_	_	_	_	_	_	_
68	equipment	_	_	_	_	_	_	_	_
69	)	_	_	_	_	_	_	_	_
70	.	_	_	_	_	_	_	_	_
71	Built	_	_	_	_	_	_	_	BeginSeg=Yes
72	on	_	_	_	_	_	_	_	_
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77	-	_	_	_	_	_	_	_	_
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79	organisms	_	_	_	_	_	_	_	_
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83	exhibit	_	_	_	_	_	_	_	_
84	a	_	_	_	_	_	_	_	_
85	dose	_	_	_	_	_	_	_	_
86	-	_	_	_	_	_	_	_	_
87	response	_	_	_	_	_	_	_	_
88	function	_	_	_	_	_	_	_	_
89	,	_	_	_	_	_	_	_	_
90	such	_	_	_	_	_	_	_	BeginSeg=Yes
91	that	_	_	_	_	_	_	_	_
92	higher	_	_	_	_	_	_	_	_
93	exposures	_	_	_	_	_	_	_	_
94	result	_	_	_	_	_	_	_	_
95	from	_	_	_	_	_	_	_	_
96	longer	_	_	_	_	_	_	_	_
97	contact	_	_	_	_	_	_	_	_
98	times	_	_	_	_	_	_	_	_
99	or	_	_	_	_	_	_	_	_
100	higher	_	_	_	_	_	_	_	_
101	air	_	_	_	_	_	_	_	_
102	concentrations	_	_	_	_	_	_	_	_
103	,	_	_	_	_	_	_	_	_
104	this	_	_	_	_	_	_	_	BeginSeg=Yes
105	control	_	_	_	_	_	_	_	_
106	banding	_	_	_	_	_	_	_	_
107	model	_	_	_	_	_	_	_	_
108	offers	_	_	_	_	_	_	_	_
109	a	_	_	_	_	_	_	_	_
110	systematic	_	_	_	_	_	_	_	_
111	method	_	_	_	_	_	_	_	_
112	for	_	_	_	_	_	_	_	BeginSeg=Yes
113	identifying	_	_	_	_	_	_	_	_
114	a	_	_	_	_	_	_	_	_
115	set	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	source	_	_	_	_	_	_	_	_
118	and	_	_	_	_	_	_	_	_
119	pathway	_	_	_	_	_	_	_	_
120	controls	_	_	_	_	_	_	_	_
121	that	_	_	_	_	_	_	_	BeginSeg=Yes
122	could	_	_	_	_	_	_	_	_
123	eliminate	_	_	_	_	_	_	_	_
124	or	_	_	_	_	_	_	_	_
125	reduce	_	_	_	_	_	_	_	_
126	the	_	_	_	_	_	_	_	_
127	need	_	_	_	_	_	_	_	_
128	for	_	_	_	_	_	_	_	_
129	receptor	_	_	_	_	_	_	_	_
130	controls	_	_	_	_	_	_	_	_
131	.	_	_	_	_	_	_	_	_
132	We	_	_	_	_	_	_	_	BeginSeg=Yes
133	describe	_	_	_	_	_	_	_	_
134	several	_	_	_	_	_	_	_	_
135	examples	_	_	_	_	_	_	_	_
136	for	_	_	_	_	_	_	_	_
137	workers	_	_	_	_	_	_	_	_
138	at	_	_	_	_	_	_	_	_
139	high	_	_	_	_	_	_	_	_
140	risk	_	_	_	_	_	_	_	_
141	of	_	_	_	_	_	_	_	_
142	exposure	_	_	_	_	_	_	_	_
143	in	_	_	_	_	_	_	_	_
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145	or	_	_	_	_	_	_	_	_
146	return	_	_	_	_	_	_	_	_
147	to	_	_	_	_	_	_	_	_
148	work	_	_	_	_	_	_	_	_
149	categories	_	_	_	_	_	_	_	_
150	.	_	_	_	_	_	_	_	_
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152	goal	_	_	_	_	_	_	_	_
153	of	_	_	_	_	_	_	_	BeginSeg=Yes
154	using	_	_	_	_	_	_	_	_
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157	for	_	_	_	_	_	_	_	_
158	such	_	_	_	_	_	_	_	_
159	workers	_	_	_	_	_	_	_	_
160	is	_	_	_	_	_	_	_	BeginSeg=Yes
161	to	_	_	_	_	_	_	_	_
162	develop	_	_	_	_	_	_	_	_
163	effective	_	_	_	_	_	_	_	_
164	infection	_	_	_	_	_	_	_	_
165	and	_	_	_	_	_	_	_	_
166	disease	_	_	_	_	_	_	_	_
167	prevention	_	_	_	_	_	_	_	_
168	programs	_	_	_	_	_	_	_	_
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170	conserve	_	_	_	_	_	_	_	_
171	personal	_	_	_	_	_	_	_	_
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173	equipment	_	_	_	_	_	_	_	_
174	.	_	_	_	_	_	_	_	_

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3	processes	_	_	_	_	_	_	_	_
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5	described	_	_	_	_	_	_	_	_
6	as	_	_	_	_	_	_	_	_
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8	series	_	_	_	_	_	_	_	_
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11	between	_	_	_	_	_	_	_	_
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13	and	_	_	_	_	_	_	_	_
14	other	_	_	_	_	_	_	_	_
15	molecules	_	_	_	_	_	_	_	_
16	,	_	_	_	_	_	_	_	_
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18	interactions	_	_	_	_	_	_	_	_
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21	turn	_	_	_	_	_	_	_	_
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24	terms	_	_	_	_	_	_	_	_
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31	protein	_	_	_	_	_	_	_	_
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53	biological	_	_	_	_	_	_	_	_
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78	proteins	_	_	_	_	_	_	_	_
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80	nucleic	_	_	_	_	_	_	_	_
81	acids	_	_	_	_	_	_	_	_
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88	.	_	_	_	_	_	_	_	_
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90	integrating	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
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93	motifs	_	_	_	_	_	_	_	_
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122	inferred	_	_	_	_	_	_	_	_
123	from	_	_	_	_	_	_	_	_
124	composite	_	_	_	_	_	_	_	_
125	motif	_	_	_	_	_	_	_	_
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128	to	_	_	_	_	_	_	_	_
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152	define	_	_	_	_	_	_	_	_
153	meta	_	_	_	_	_	_	_	_
154	-	_	_	_	_	_	_	_	_
155	composite	_	_	_	_	_	_	_	_
156	motifs	_	_	_	_	_	_	_	_
157	each	_	_	_	_	_	_	_	BeginSeg=Yes
158	of	_	_	_	_	_	_	_	_
159	which	_	_	_	_	_	_	_	_
160	is	_	_	_	_	_	_	_	_
161	regarded	_	_	_	_	_	_	_	_
162	as	_	_	_	_	_	_	_	_
163	a	_	_	_	_	_	_	_	_
164	time	_	_	_	_	_	_	_	_
165	-	_	_	_	_	_	_	_	_
166	independent	_	_	_	_	_	_	_	_
167	diagrammatic	_	_	_	_	_	_	_	_
168	representation	_	_	_	_	_	_	_	_
169	of	_	_	_	_	_	_	_	_
170	a	_	_	_	_	_	_	_	_
171	biological	_	_	_	_	_	_	_	_
172	process	_	_	_	_	_	_	_	_
173	.	_	_	_	_	_	_	_	_
174	It	_	_	_	_	_	_	_	BeginSeg=Yes
175	is	_	_	_	_	_	_	_	_
176	shown	_	_	_	_	_	_	_	_
177	that	_	_	_	_	_	_	_	_
178	meta	_	_	_	_	_	_	_	_
179	-	_	_	_	_	_	_	_	_
180	composite	_	_	_	_	_	_	_	_
181	motifs	_	_	_	_	_	_	_	_
182	provide	_	_	_	_	_	_	_	_
183	richer	_	_	_	_	_	_	_	_
184	annotations	_	_	_	_	_	_	_	_
185	of	_	_	_	_	_	_	_	_
186	biological	_	_	_	_	_	_	_	_
187	processes	_	_	_	_	_	_	_	_
188	than	_	_	_	_	_	_	_	_
189	sequence	_	_	_	_	_	_	_	_
190	clusters	_	_	_	_	_	_	_	_
191	.	_	_	_	_	_	_	_	_
192	The	_	_	_	_	_	_	_	BeginSeg=Yes
193	present	_	_	_	_	_	_	_	_
194	results	_	_	_	_	_	_	_	_
195	serve	_	_	_	_	_	_	_	_
196	as	_	_	_	_	_	_	_	_
197	a	_	_	_	_	_	_	_	_
198	basis	_	_	_	_	_	_	_	_
199	for	_	_	_	_	_	_	_	BeginSeg=Yes
200	bridging	_	_	_	_	_	_	_	_
201	atomic	_	_	_	_	_	_	_	_
202	structures	_	_	_	_	_	_	_	_
203	to	_	_	_	_	_	_	_	_
204	higher	_	_	_	_	_	_	_	_
205	-	_	_	_	_	_	_	_	_
206	order	_	_	_	_	_	_	_	_
207	biological	_	_	_	_	_	_	_	_
208	phenomena	_	_	_	_	_	_	_	_
209	by	_	_	_	_	_	_	_	_
210	classification	_	_	_	_	_	_	_	_
211	and	_	_	_	_	_	_	_	_
212	integration	_	_	_	_	_	_	_	_
213	of	_	_	_	_	_	_	_	_
214	binding	_	_	_	_	_	_	_	_
215	site	_	_	_	_	_	_	_	_
216	structures	_	_	_	_	_	_	_	_
217	.	_	_	_	_	_	_	_	_

# newdoc_id = 6ad3708c2049874524e4242c18e8fb41c673ccde
1	Interferons	_	_	_	_	_	_	_	BeginSeg=Yes
2	(	_	_	_	_	_	_	_	_
3	IFNs	_	_	_	_	_	_	_	_
4	)	_	_	_	_	_	_	_	_
5	are	_	_	_	_	_	_	_	_
6	secreted	_	_	_	_	_	_	_	_
7	proteins	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	_
9	the	_	_	_	_	_	_	_	_
10	cytokine	_	_	_	_	_	_	_	_
11	family	_	_	_	_	_	_	_	_
12	that	_	_	_	_	_	_	_	BeginSeg=Yes
13	regulate	_	_	_	_	_	_	_	_
14	innate	_	_	_	_	_	_	_	_
15	and	_	_	_	_	_	_	_	_
16	adaptive	_	_	_	_	_	_	_	_
17	immune	_	_	_	_	_	_	_	_
18	responses	_	_	_	_	_	_	_	_
19	to	_	_	_	_	_	_	_	_
20	infection	_	_	_	_	_	_	_	_
21	.	_	_	_	_	_	_	_	_
22	Although	_	_	_	_	_	_	_	BeginSeg=Yes
23	the	_	_	_	_	_	_	_	_
24	importance	_	_	_	_	_	_	_	_
25	of	_	_	_	_	_	_	_	_
26	IFNs	_	_	_	_	_	_	_	_
27	in	_	_	_	_	_	_	_	_
28	the	_	_	_	_	_	_	_	_
29	antiviral	_	_	_	_	_	_	_	_
30	response	_	_	_	_	_	_	_	_
31	has	_	_	_	_	_	_	_	_
32	long	_	_	_	_	_	_	_	_
33	been	_	_	_	_	_	_	_	_
34	appreciated	_	_	_	_	_	_	_	_
35	,	_	_	_	_	_	_	_	_
36	their	_	_	_	_	_	_	_	BeginSeg=Yes
37	role	_	_	_	_	_	_	_	_
38	in	_	_	_	_	_	_	_	_
39	bacterial	_	_	_	_	_	_	_	_
40	infections	_	_	_	_	_	_	_	_
41	is	_	_	_	_	_	_	_	_
42	more	_	_	_	_	_	_	_	_
43	complex	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	BeginSeg=Yes
45	is	_	_	_	_	_	_	_	_
46	currently	_	_	_	_	_	_	_	_
47	a	_	_	_	_	_	_	_	_
48	major	_	_	_	_	_	_	_	_
49	focus	_	_	_	_	_	_	_	_
50	of	_	_	_	_	_	_	_	_
51	investigation	_	_	_	_	_	_	_	_
52	.	_	_	_	_	_	_	_	_
53	This	_	_	_	_	_	_	_	BeginSeg=Yes
54	review	_	_	_	_	_	_	_	_
55	summarizes	_	_	_	_	_	_	_	_
56	our	_	_	_	_	_	_	_	_
57	current	_	_	_	_	_	_	_	_
58	knowledge	_	_	_	_	_	_	_	_
59	of	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	role	_	_	_	_	_	_	_	_
62	of	_	_	_	_	_	_	_	_
63	these	_	_	_	_	_	_	_	_
64	cytokines	_	_	_	_	_	_	_	_
65	in	_	_	_	_	_	_	_	_
66	host	_	_	_	_	_	_	_	_
67	defense	_	_	_	_	_	_	_	_
68	against	_	_	_	_	_	_	_	_
69	the	_	_	_	_	_	_	_	_
70	bacterial	_	_	_	_	_	_	_	_
71	pathogen	_	_	_	_	_	_	_	_
72	Listeria	_	_	_	_	_	_	_	_
73	monocytogenes	_	_	_	_	_	_	_	_
74	and	_	_	_	_	_	_	_	BeginSeg=Yes
75	highlights	_	_	_	_	_	_	_	_
76	recent	_	_	_	_	_	_	_	_
77	discoveries	_	_	_	_	_	_	_	_
78	on	_	_	_	_	_	_	_	_
79	the	_	_	_	_	_	_	_	_
80	molecular	_	_	_	_	_	_	_	_
81	mechanisms	_	_	_	_	_	_	_	_
82	evolved	_	_	_	_	_	_	_	BeginSeg=Yes
83	by	_	_	_	_	_	_	_	_
84	this	_	_	_	_	_	_	_	_
85	intracellular	_	_	_	_	_	_	_	_
86	bacterium	_	_	_	_	_	_	_	_
87	to	_	_	_	_	_	_	_	BeginSeg=Yes
88	subvert	_	_	_	_	_	_	_	_
89	IFN	_	_	_	_	_	_	_	_
90	responses	_	_	_	_	_	_	_	_
91	.	_	_	_	_	_	_	_	_

# newdoc_id = 6c26acf9ba8059cbd9caa58acb1a64538cfb7df9
1	H9N2	_	_	_	_	_	_	_	BeginSeg=Yes
2	Avian	_	_	_	_	_	_	_	_
3	influenza	_	_	_	_	_	_	_	_
4	virus	_	_	_	_	_	_	_	_
5	has	_	_	_	_	_	_	_	_
6	repeatedly	_	_	_	_	_	_	_	_
7	infected	_	_	_	_	_	_	_	_
8	humans	_	_	_	_	_	_	_	_
9	and	_	_	_	_	_	_	_	_
10	other	_	_	_	_	_	_	_	_
11	mammals	_	_	_	_	_	_	_	_
12	,	_	_	_	_	_	_	_	_
13	which	_	_	_	_	_	_	_	BeginSeg=Yes
14	highlights	_	_	_	_	_	_	_	_
15	the	_	_	_	_	_	_	_	_
16	need	_	_	_	_	_	_	_	_
17	to	_	_	_	_	_	_	_	BeginSeg=Yes
18	determine	_	_	_	_	_	_	_	_
19	the	_	_	_	_	_	_	_	_
20	pathogenicity	_	_	_	_	_	_	_	_
21	and	_	_	_	_	_	_	_	_
22	the	_	_	_	_	_	_	_	_
23	corresponding	_	_	_	_	_	_	_	_
24	mechanism	_	_	_	_	_	_	_	_
25	of	_	_	_	_	_	_	_	_
26	this	_	_	_	_	_	_	_	_
27	virus	_	_	_	_	_	_	_	_
28	for	_	_	_	_	_	_	_	_
29	mammals	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	In	_	_	_	_	_	_	_	BeginSeg=Yes
32	this	_	_	_	_	_	_	_	_
33	study	_	_	_	_	_	_	_	_
34	,	_	_	_	_	_	_	_	_
35	we	_	_	_	_	_	_	_	_
36	found	_	_	_	_	_	_	_	_
37	two	_	_	_	_	_	_	_	_
38	H9N2	_	_	_	_	_	_	_	_
39	viruses	_	_	_	_	_	_	_	_
40	with	_	_	_	_	_	_	_	_
41	similar	_	_	_	_	_	_	_	_
42	genetic	_	_	_	_	_	_	_	_
43	background	_	_	_	_	_	_	_	_
44	but	_	_	_	_	_	_	_	_
45	with	_	_	_	_	_	_	_	_
46	different	_	_	_	_	_	_	_	_
47	pathogenicity	_	_	_	_	_	_	_	_
48	in	_	_	_	_	_	_	_	_
49	mice	_	_	_	_	_	_	_	_
50	.	_	_	_	_	_	_	_	_
51	The	_	_	_	_	_	_	_	BeginSeg=Yes
52	A	_	_	_	_	_	_	_	_
53	/	_	_	_	_	_	_	_	_
54	duck	_	_	_	_	_	_	_	_
55	/	_	_	_	_	_	_	_	_
56	Nanjing/06/2003	_	_	_	_	_	_	_	_
57	(	_	_	_	_	_	_	_	_
58	NJ06	_	_	_	_	_	_	_	_
59	)	_	_	_	_	_	_	_	_
60	virus	_	_	_	_	_	_	_	_
61	was	_	_	_	_	_	_	_	_
62	highly	_	_	_	_	_	_	_	_
63	pathogenic	_	_	_	_	_	_	_	_
64	for	_	_	_	_	_	_	_	_
65	mice	_	_	_	_	_	_	_	_
66	,	_	_	_	_	_	_	_	_
67	with	_	_	_	_	_	_	_	_
68	a	_	_	_	_	_	_	_	_
69	50	_	_	_	_	_	_	_	_
70	%	_	_	_	_	_	_	_	_
71	mouse	_	_	_	_	_	_	_	_
72	lethal	_	_	_	_	_	_	_	_
73	dose	_	_	_	_	_	_	_	_
74	(	_	_	_	_	_	_	_	_
75	MLD	_	_	_	_	_	_	_	_
76	50	_	_	_	_	_	_	_	_
77	)	_	_	_	_	_	_	_	_
78	of	_	_	_	_	_	_	_	_
79	10	_	_	_	_	_	_	_	_
80	2.83	_	_	_	_	_	_	_	_
81	50	_	_	_	_	_	_	_	_
82	%	_	_	_	_	_	_	_	_
83	egg	_	_	_	_	_	_	_	_
84	infectious	_	_	_	_	_	_	_	_
85	dose	_	_	_	_	_	_	_	_
86	(	_	_	_	_	_	_	_	_
87	EID	_	_	_	_	_	_	_	_
88	50	_	_	_	_	_	_	_	_
89	)	_	_	_	_	_	_	_	_
90	,	_	_	_	_	_	_	_	_
91	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
92	the	_	_	_	_	_	_	_	_
93	A	_	_	_	_	_	_	_	_
94	/	_	_	_	_	_	_	_	_
95	duck	_	_	_	_	_	_	_	_
96	/	_	_	_	_	_	_	_	_
97	Nanjing/01/1999	_	_	_	_	_	_	_	_
98	(	_	_	_	_	_	_	_	_
99	NJ01	_	_	_	_	_	_	_	_
100	)	_	_	_	_	_	_	_	_
101	virus	_	_	_	_	_	_	_	_
102	was	_	_	_	_	_	_	_	_
103	low	_	_	_	_	_	_	_	_
104	pathogenic	_	_	_	_	_	_	_	_
105	for	_	_	_	_	_	_	_	_
106	mice	_	_	_	_	_	_	_	_
107	,	_	_	_	_	_	_	_	_
108	with	_	_	_	_	_	_	_	_
109	a	_	_	_	_	_	_	_	_
110	MLD	_	_	_	_	_	_	_	_
111	6.81	_	_	_	_	_	_	_	_
112	50	_	_	_	_	_	_	_	_
113	of	_	_	_	_	_	_	_	_
114	>	_	_	_	_	_	_	_	_
115	10	_	_	_	_	_	_	_	_
116	EID	_	_	_	_	_	_	_	_
117	50	_	_	_	_	_	_	_	_
118	.	_	_	_	_	_	_	_	_
119	Further	_	_	_	_	_	_	_	BeginSeg=Yes
120	studies	_	_	_	_	_	_	_	_
121	showed	_	_	_	_	_	_	_	_
122	that	_	_	_	_	_	_	_	BeginSeg=Yes
123	the	_	_	_	_	_	_	_	_
124	NJ06	_	_	_	_	_	_	_	_
125	virus	_	_	_	_	_	_	_	_
126	grew	_	_	_	_	_	_	_	_
127	faster	_	_	_	_	_	_	_	_
128	and	_	_	_	_	_	_	_	BeginSeg=Yes
129	reached	_	_	_	_	_	_	_	_
130	significantly	_	_	_	_	_	_	_	_
131	higher	_	_	_	_	_	_	_	_
132	titers	_	_	_	_	_	_	_	_
133	than	_	_	_	_	_	_	_	_
134	NJ01	_	_	_	_	_	_	_	_
135	in	_	_	_	_	_	_	_	_
136	vivo	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	_
138	in	_	_	_	_	_	_	_	_
139	vitro	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	Moreover	_	_	_	_	_	_	_	BeginSeg=Yes
142	,	_	_	_	_	_	_	_	_
143	the	_	_	_	_	_	_	_	_
144	NJ06	_	_	_	_	_	_	_	_
145	virus	_	_	_	_	_	_	_	_
146	induced	_	_	_	_	_	_	_	_
147	more	_	_	_	_	_	_	_	_
148	severe	_	_	_	_	_	_	_	_
149	lung	_	_	_	_	_	_	_	_
150	lesions	_	_	_	_	_	_	_	_
151	,	_	_	_	_	_	_	_	_
152	and	_	_	_	_	_	_	_	_
153	higher	_	_	_	_	_	_	_	_
154	levels	_	_	_	_	_	_	_	_
155	of	_	_	_	_	_	_	_	_
156	inflammatory	_	_	_	_	_	_	_	_
157	cellular	_	_	_	_	_	_	_	_
158	infiltration	_	_	_	_	_	_	_	_
159	and	_	_	_	_	_	_	_	_
160	cytokine	_	_	_	_	_	_	_	_
161	response	_	_	_	_	_	_	_	_
162	in	_	_	_	_	_	_	_	_
163	lungs	_	_	_	_	_	_	_	_
164	than	_	_	_	_	_	_	_	_
165	NJ01	_	_	_	_	_	_	_	_
166	did	_	_	_	_	_	_	_	_
167	.	_	_	_	_	_	_	_	_
168	However	_	_	_	_	_	_	_	BeginSeg=Yes
169	,	_	_	_	_	_	_	_	_
170	only	_	_	_	_	_	_	_	_
171	12	_	_	_	_	_	_	_	_
172	different	_	_	_	_	_	_	_	_
173	amino	_	_	_	_	_	_	_	_
174	acid	_	_	_	_	_	_	_	_
175	residues	_	_	_	_	_	_	_	_
176	(	_	_	_	_	_	_	_	BeginSeg=Yes
177	HA	_	_	_	_	_	_	_	_
178	-	_	_	_	_	_	_	_	_
179	K157E	_	_	_	_	_	_	_	_
180	,	_	_	_	_	_	_	_	_
181	NA	_	_	_	_	_	_	_	_
182	-	_	_	_	_	_	_	_	_
183	A9	_	_	_	_	_	_	_	_
184	T	_	_	_	_	_	_	_	_
185	,	_	_	_	_	_	_	_	_
186	NA	_	_	_	_	_	_	_	_
187	-	_	_	_	_	_	_	_	_
188	R435	_	_	_	_	_	_	_	_
189	K	_	_	_	_	_	_	_	_
190	,	_	_	_	_	_	_	_	_
191	PB2-T149P	_	_	_	_	_	_	_	_
192	,	_	_	_	_	_	_	_	_
193	PB2-K627E	_	_	_	_	_	_	_	_
194	,	_	_	_	_	_	_	_	_
195	PB1-R187	_	_	_	_	_	_	_	_
196	K	_	_	_	_	_	_	_	_
197	,	_	_	_	_	_	_	_	_
198	PA	_	_	_	_	_	_	_	_
199	-	_	_	_	_	_	_	_	_
200	L548	_	_	_	_	_	_	_	_
201	M	_	_	_	_	_	_	_	_
202	,	_	_	_	_	_	_	_	_
203	PA	_	_	_	_	_	_	_	_
204	-	_	_	_	_	_	_	_	_
205	M550L	_	_	_	_	_	_	_	_
206	,	_	_	_	_	_	_	_	_
207	NP	_	_	_	_	_	_	_	_
208	-	_	_	_	_	_	_	_	_
209	G127E	_	_	_	_	_	_	_	_
210	,	_	_	_	_	_	_	_	_
211	NP	_	_	_	_	_	_	_	_
212	-	_	_	_	_	_	_	_	_
213	P277H	_	_	_	_	_	_	_	_
214	,	_	_	_	_	_	_	_	_
215	NP	_	_	_	_	_	_	_	_
216	-	_	_	_	_	_	_	_	_
217	D340N	_	_	_	_	_	_	_	_
218	,	_	_	_	_	_	_	_	_
219	NS1-D171N	_	_	_	_	_	_	_	_
220	)	_	_	_	_	_	_	_	_
221	were	_	_	_	_	_	_	_	BeginSeg=Yes
222	found	_	_	_	_	_	_	_	_
223	between	_	_	_	_	_	_	_	_
224	the	_	_	_	_	_	_	_	_
225	two	_	_	_	_	_	_	_	_
226	viruses	_	_	_	_	_	_	_	_
227	,	_	_	_	_	_	_	_	_
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229	all	_	_	_	_	_	_	_	_
230	these	_	_	_	_	_	_	_	_
231	residues	_	_	_	_	_	_	_	_
232	except	_	_	_	_	_	_	_	_
233	for	_	_	_	_	_	_	_	_
234	NA	_	_	_	_	_	_	_	_
235	-	_	_	_	_	_	_	_	_
236	R435	_	_	_	_	_	_	_	_
237	K	_	_	_	_	_	_	_	_
238	were	_	_	_	_	_	_	_	_
239	located	_	_	_	_	_	_	_	_
240	in	_	_	_	_	_	_	_	_
241	the	_	_	_	_	_	_	_	_
242	known	_	_	_	_	_	_	_	_
243	functional	_	_	_	_	_	_	_	_
244	regions	_	_	_	_	_	_	_	_
245	involved	_	_	_	_	_	_	_	BeginSeg=Yes
246	in	_	_	_	_	_	_	_	_
247	interaction	_	_	_	_	_	_	_	_
248	of	_	_	_	_	_	_	_	_
249	viral	_	_	_	_	_	_	_	_
250	proteins	_	_	_	_	_	_	_	_
251	or	_	_	_	_	_	_	_	_
252	between	_	_	_	_	_	_	_	_
253	the	_	_	_	_	_	_	_	_
254	virus	_	_	_	_	_	_	_	_
255	and	_	_	_	_	_	_	_	_
256	host	_	_	_	_	_	_	_	_
257	factors	_	_	_	_	_	_	_	_
258	.	_	_	_	_	_	_	_	_
259	Summary	_	_	_	_	_	_	_	BeginSeg=Yes
260	,	_	_	_	_	_	_	_	_
261	our	_	_	_	_	_	_	_	_
262	results	_	_	_	_	_	_	_	_
263	suggest	_	_	_	_	_	_	_	_
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265	multiple	_	_	_	_	_	_	_	_
266	amino	_	_	_	_	_	_	_	_
267	acid	_	_	_	_	_	_	_	_
268	differences	_	_	_	_	_	_	_	_
269	may	_	_	_	_	_	_	_	_
270	be	_	_	_	_	_	_	_	_
271	responsible	_	_	_	_	_	_	_	_
272	for	_	_	_	_	_	_	_	_
273	the	_	_	_	_	_	_	_	_
274	higher	_	_	_	_	_	_	_	_
275	pathogenicity	_	_	_	_	_	_	_	_
276	of	_	_	_	_	_	_	_	_
277	the	_	_	_	_	_	_	_	_
278	NJ06	_	_	_	_	_	_	_	_
279	virus	_	_	_	_	_	_	_	_
280	for	_	_	_	_	_	_	_	_
281	mice	_	_	_	_	_	_	_	_
282	,	_	_	_	_	_	_	_	_
283	resulting	_	_	_	_	_	_	_	BeginSeg=Yes
284	in	_	_	_	_	_	_	_	_
285	lethal	_	_	_	_	_	_	_	_
286	infection	_	_	_	_	_	_	_	_
287	,	_	_	_	_	_	_	_	_
288	enhanced	_	_	_	_	_	_	_	_
289	viral	_	_	_	_	_	_	_	_
290	replication	_	_	_	_	_	_	_	_
291	,	_	_	_	_	_	_	_	_
292	severe	_	_	_	_	_	_	_	_
293	lung	_	_	_	_	_	_	_	_
294	lesions	_	_	_	_	_	_	_	_
295	,	_	_	_	_	_	_	_	_
296	and	_	_	_	_	_	_	_	_
297	excessive	_	_	_	_	_	_	_	_
298	inflammatory	_	_	_	_	_	_	_	_
299	cellular	_	_	_	_	_	_	_	_
300	infiltration	_	_	_	_	_	_	_	_
301	and	_	_	_	_	_	_	_	_
302	cytokine	_	_	_	_	_	_	_	_
303	response	_	_	_	_	_	_	_	_
304	in	_	_	_	_	_	_	_	_
305	lungs	_	_	_	_	_	_	_	_
306	.	_	_	_	_	_	_	_	_
307	These	_	_	_	_	_	_	_	BeginSeg=Yes
308	observations	_	_	_	_	_	_	_	_
309	will	_	_	_	_	_	_	_	_
310	be	_	_	_	_	_	_	_	_
311	helpful	_	_	_	_	_	_	_	_
312	for	_	_	_	_	_	_	_	_
313	better	_	_	_	_	_	_	_	_
314	understanding	_	_	_	_	_	_	_	_
315	the	_	_	_	_	_	_	_	_
316	pathogenic	_	_	_	_	_	_	_	_
317	potential	_	_	_	_	_	_	_	_
318	and	_	_	_	_	_	_	_	_
319	the	_	_	_	_	_	_	_	_
320	corresponding	_	_	_	_	_	_	_	_
321	molecular	_	_	_	_	_	_	_	_
322	basis	_	_	_	_	_	_	_	_
323	of	_	_	_	_	_	_	_	_
324	H9N2	_	_	_	_	_	_	_	_
325	viruses	_	_	_	_	_	_	_	_
326	that	_	_	_	_	_	_	_	BeginSeg=Yes
327	might	_	_	_	_	_	_	_	_
328	pose	_	_	_	_	_	_	_	_
329	threats	_	_	_	_	_	_	_	_
330	to	_	_	_	_	_	_	_	_
331	human	_	_	_	_	_	_	_	_
332	health	_	_	_	_	_	_	_	_
333	in	_	_	_	_	_	_	_	_
334	the	_	_	_	_	_	_	_	_
335	future	_	_	_	_	_	_	_	_
336	.	_	_	_	_	_	_	_	_

# newdoc_id = 6c7490b3cf8a1eb555a400f3f2685d332be814e0
1	This	_	_	_	_	_	_	_	BeginSeg=Yes
2	paper	_	_	_	_	_	_	_	_
3	revisits	_	_	_	_	_	_	_	_
4-5	Jessop's	_	_	_	_	_	_	_	_
4	Jessop	_	_	_	_	_	_	_	_
5	's	_	_	_	_	_	_	_	_
6	governance	_	_	_	_	_	_	_	_
7	of	_	_	_	_	_	_	_	_
8	welfare	_	_	_	_	_	_	_	_
9	framework	_	_	_	_	_	_	_	_
10	,	_	_	_	_	_	_	_	_
11	suggesting	_	_	_	_	_	_	_	BeginSeg=Yes
12	that	_	_	_	_	_	_	_	BeginSeg=Yes
13	in	_	_	_	_	_	_	_	_
14	the	_	_	_	_	_	_	_	_
15	post	_	_	_	_	_	_	_	_
16	-	_	_	_	_	_	_	_	_
17	financial	_	_	_	_	_	_	_	_
18	crisis	_	_	_	_	_	_	_	_
19	era	_	_	_	_	_	_	_	_
20	of	_	_	_	_	_	_	_	_
21	austerity	_	_	_	_	_	_	_	_
22	we	_	_	_	_	_	_	_	_
23	need	_	_	_	_	_	_	_	_
24	to	_	_	_	_	_	_	_	_
25	look	_	_	_	_	_	_	_	_
26	again	_	_	_	_	_	_	_	_
27	at	_	_	_	_	_	_	_	_
28	its	_	_	_	_	_	_	_	_
29	analytical	_	_	_	_	_	_	_	_
30	dimensions	_	_	_	_	_	_	_	_
31	.	_	_	_	_	_	_	_	_
32	The	_	_	_	_	_	_	_	BeginSeg=Yes
33	paper	_	_	_	_	_	_	_	_
34	reformulates	_	_	_	_	_	_	_	_
35-36	Jessop's	_	_	_	_	_	_	_	_
35	Jessop	_	_	_	_	_	_	_	_
36	's	_	_	_	_	_	_	_	_
37	Schumpeterian	_	_	_	_	_	_	_	_
38	Welfare	_	_	_	_	_	_	_	_
39	Postnational	_	_	_	_	_	_	_	_
40	Regime	_	_	_	_	_	_	_	_
41	ideal	_	_	_	_	_	_	_	_
42	-	_	_	_	_	_	_	_	_
43	type	_	_	_	_	_	_	_	_
44	framework	_	_	_	_	_	_	_	_
45	through	_	_	_	_	_	_	_	_
46	critique	_	_	_	_	_	_	_	_
47	,	_	_	_	_	_	_	_	_
48	and	_	_	_	_	_	_	_	BeginSeg=Yes
49	then	_	_	_	_	_	_	_	_
50	applies	_	_	_	_	_	_	_	_
51	its	_	_	_	_	_	_	_	_
52	reformulated	_	_	_	_	_	_	_	_
53	Galbrathian	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	Affluent	_	_	_	_	_	_	_	_
56	Postnational	_	_	_	_	_	_	_	_
57	Oligarchy	_	_	_	_	_	_	_	_
58	ideal	_	_	_	_	_	_	_	_
59	-	_	_	_	_	_	_	_	_
60	type	_	_	_	_	_	_	_	_
61	to	_	_	_	_	_	_	_	_
62	the	_	_	_	_	_	_	_	_
63	case	_	_	_	_	_	_	_	_
64	of	_	_	_	_	_	_	_	_
65	the	_	_	_	_	_	_	_	_
66	English	_	_	_	_	_	_	_	_
67	NHS	_	_	_	_	_	_	_	_
68	to	_	_	_	_	_	_	_	BeginSeg=Yes
69	present	_	_	_	_	_	_	_	_
70	a	_	_	_	_	_	_	_	_
71	new	_	_	_	_	_	_	_	_
72	political	_	_	_	_	_	_	_	_
73	economy	_	_	_	_	_	_	_	_
74	of	_	_	_	_	_	_	_	_
75	health	_	_	_	_	_	_	_	_
76	.	_	_	_	_	_	_	_	_

# newdoc_id = 6cc9687cc3d778c4599f09cf044627beffb07dca
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2	is	_	_	_	_	_	_	_	_
3	an	_	_	_	_	_	_	_	_
4	urgent	_	_	_	_	_	_	_	_
5	need	_	_	_	_	_	_	_	_
6	for	_	_	_	_	_	_	_	BeginSeg=Yes
7	new	_	_	_	_	_	_	_	_
8	therapeutic	_	_	_	_	_	_	_	_
9	strategies	_	_	_	_	_	_	_	_
10	to	_	_	_	_	_	_	_	_
11	contain	_	_	_	_	_	_	_	_
12	the	_	_	_	_	_	_	_	_
13	spread	_	_	_	_	_	_	_	_
14	of	_	_	_	_	_	_	_	_
15	the	_	_	_	_	_	_	_	_
16	novel	_	_	_	_	_	_	_	_
17	coronavirus	_	_	_	_	_	_	_	_
18	disease	_	_	_	_	_	_	_	_
19	2019	_	_	_	_	_	_	_	_
20	and	_	_	_	_	_	_	_	BeginSeg=Yes
21	to	_	_	_	_	_	_	_	_
22	curtail	_	_	_	_	_	_	_	_
23	its	_	_	_	_	_	_	_	_
24	most	_	_	_	_	_	_	_	_
25	severe	_	_	_	_	_	_	_	_
26	complications	_	_	_	_	_	_	_	_
27	.	_	_	_	_	_	_	_	_
28	Severely	_	_	_	_	_	_	_	BeginSeg=Yes
29	ill	_	_	_	_	_	_	_	_
30	patients	_	_	_	_	_	_	_	_
31	experience	_	_	_	_	_	_	_	_
32	pathologic	_	_	_	_	_	_	_	_
33	manifestations	_	_	_	_	_	_	_	_
34	of	_	_	_	_	_	_	_	_
35	acute	_	_	_	_	_	_	_	_
36	respiratory	_	_	_	_	_	_	_	_
37	distress	_	_	_	_	_	_	_	_
38	syndrome	_	_	_	_	_	_	_	_
39	(	_	_	_	_	_	_	_	_
40	ARDS	_	_	_	_	_	_	_	_
41	)	_	_	_	_	_	_	_	_
42	,	_	_	_	_	_	_	_	_
43	and	_	_	_	_	_	_	_	BeginSeg=Yes
44	clinical	_	_	_	_	_	_	_	_
45	reports	_	_	_	_	_	_	_	_
46	demonstrate	_	_	_	_	_	_	_	_
47	striking	_	_	_	_	_	_	_	_
48	neutrophilia	_	_	_	_	_	_	_	_
49	,	_	_	_	_	_	_	_	_
50	elevated	_	_	_	_	_	_	_	_
51	levels	_	_	_	_	_	_	_	_
52	of	_	_	_	_	_	_	_	_
53	multiple	_	_	_	_	_	_	_	_
54	cytokines	_	_	_	_	_	_	_	_
55	,	_	_	_	_	_	_	_	_
56	and	_	_	_	_	_	_	_	_
57	an	_	_	_	_	_	_	_	_
58	exaggerated	_	_	_	_	_	_	_	_
59	inflammatory	_	_	_	_	_	_	_	_
60	response	_	_	_	_	_	_	_	_
61	in	_	_	_	_	_	_	_	_
62	fatal	_	_	_	_	_	_	_	_
63	COVID-19	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
65	Mechanical	_	_	_	_	_	_	_	BeginSeg=Yes
66	respirator	_	_	_	_	_	_	_	_
67	devices	_	_	_	_	_	_	_	_
68	are	_	_	_	_	_	_	_	_
69	the	_	_	_	_	_	_	_	_
70	most	_	_	_	_	_	_	_	_
71	widely	_	_	_	_	_	_	_	_
72	applied	_	_	_	_	_	_	_	_
73	therapy	_	_	_	_	_	_	_	_
74	for	_	_	_	_	_	_	_	_
75	ARDS	_	_	_	_	_	_	_	_
76	in	_	_	_	_	_	_	_	_
77	COVID-19	_	_	_	_	_	_	_	_
78	,	_	_	_	_	_	_	_	_
79	yet	_	_	_	_	_	_	_	BeginSeg=Yes
80	mechanical	_	_	_	_	_	_	_	_
81	ventilation	_	_	_	_	_	_	_	_
82	achieves	_	_	_	_	_	_	_	_
83	strikingly	_	_	_	_	_	_	_	_
84	poor	_	_	_	_	_	_	_	_
85	survival	_	_	_	_	_	_	_	_
86	.	_	_	_	_	_	_	_	_
87	Many	_	_	_	_	_	_	_	BeginSeg=Yes
88	patients	_	_	_	_	_	_	_	_
89	,	_	_	_	_	_	_	_	_
90	who	_	_	_	_	_	_	_	BeginSeg=Yes
91	recover	_	_	_	_	_	_	_	_
92	,	_	_	_	_	_	_	_	_
93	experience	_	_	_	_	_	_	_	BeginSeg=Yes
94	impaired	_	_	_	_	_	_	_	_
95	cognition	_	_	_	_	_	_	_	_
96	or	_	_	_	_	_	_	_	_
97	physical	_	_	_	_	_	_	_	_
98	disability	_	_	_	_	_	_	_	_
99	.	_	_	_	_	_	_	_	_
100	In	_	_	_	_	_	_	_	BeginSeg=Yes
101	this	_	_	_	_	_	_	_	_
102	review	_	_	_	_	_	_	_	_
103	,	_	_	_	_	_	_	_	_
104	we	_	_	_	_	_	_	_	_
105	argue	_	_	_	_	_	_	_	_
106	the	_	_	_	_	_	_	_	_
107	need	_	_	_	_	_	_	_	_
108	to	_	_	_	_	_	_	_	BeginSeg=Yes
109	develop	_	_	_	_	_	_	_	_
110	therapies	_	_	_	_	_	_	_	_
111	aimed	_	_	_	_	_	_	_	BeginSeg=Yes
112	at	_	_	_	_	_	_	_	_
113	inhibiting	_	_	_	_	_	_	_	_
114	neutrophil	_	_	_	_	_	_	_	_
115	recruitment	_	_	_	_	_	_	_	_
116	,	_	_	_	_	_	_	_	_
117	activation	_	_	_	_	_	_	_	_
118	,	_	_	_	_	_	_	_	_
119	degranulation	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	and	_	_	_	_	_	_	_	_
122	neutrophil	_	_	_	_	_	_	_	_
123	extracellular	_	_	_	_	_	_	_	_
124	trap	_	_	_	_	_	_	_	_
125	(	_	_	_	_	_	_	_	_
126	NET	_	_	_	_	_	_	_	_
127	)	_	_	_	_	_	_	_	_
128	release	_	_	_	_	_	_	_	_
129	.	_	_	_	_	_	_	_	_
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131	,	_	_	_	_	_	_	_	_
132	we	_	_	_	_	_	_	_	_
133	suggest	_	_	_	_	_	_	_	_
134	that	_	_	_	_	_	_	_	BeginSeg=Yes
135	currently	_	_	_	_	_	_	_	_
136	available	_	_	_	_	_	_	_	_
137	pharmacologic	_	_	_	_	_	_	_	_
138	approaches	_	_	_	_	_	_	_	_
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140	be	_	_	_	_	_	_	_	_
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142	as	_	_	_	_	_	_	_	_
143	treatments	_	_	_	_	_	_	_	_
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145	ARDS	_	_	_	_	_	_	_	_
146	in	_	_	_	_	_	_	_	_
147	COVID-19	_	_	_	_	_	_	_	_
148	.	_	_	_	_	_	_	_	_
149	In	_	_	_	_	_	_	_	BeginSeg=Yes
150	our	_	_	_	_	_	_	_	_
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152	,	_	_	_	_	_	_	_	_
153	targeting	_	_	_	_	_	_	_	_
154	host	_	_	_	_	_	_	_	_
155	-	_	_	_	_	_	_	_	_
156	mediated	_	_	_	_	_	_	_	_
157	immunopathology	_	_	_	_	_	_	_	_
158	holds	_	_	_	_	_	_	_	_
159	promise	_	_	_	_	_	_	_	_
160	to	_	_	_	_	_	_	_	BeginSeg=Yes
161	alleviate	_	_	_	_	_	_	_	_
162	progressive	_	_	_	_	_	_	_	_
163	pathologic	_	_	_	_	_	_	_	_
164	complications	_	_	_	_	_	_	_	_
165	of	_	_	_	_	_	_	_	_
166	ARDS	_	_	_	_	_	_	_	_
167	and	_	_	_	_	_	_	_	BeginSeg=Yes
168	reduce	_	_	_	_	_	_	_	_
169	morbidities	_	_	_	_	_	_	_	_
170	and	_	_	_	_	_	_	_	_
171	mortalities	_	_	_	_	_	_	_	_
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173	severely	_	_	_	_	_	_	_	_
174	ill	_	_	_	_	_	_	_	_
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271	PPE	_	_	_	_	_	_	_	_
272	.	_	_	_	_	_	_	_	_

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100	the	_	_	_	_	_	_	_	_
101	interactome	_	_	_	_	_	_	_	_
102	of	_	_	_	_	_	_	_	_
103	these	_	_	_	_	_	_	_	_
104	viral	_	_	_	_	_	_	_	_
105	proteins	_	_	_	_	_	_	_	_
106	with	_	_	_	_	_	_	_	_
107	the	_	_	_	_	_	_	_	_
108	host	_	_	_	_	_	_	_	_
109	proteins	_	_	_	_	_	_	_	_
110	is	_	_	_	_	_	_	_	_
111	analyzed	_	_	_	_	_	_	_	_
112	.	_	_	_	_	_	_	_	_
113	The	_	_	_	_	_	_	_	BeginSeg=Yes
114	statistical	_	_	_	_	_	_	_	_
115	analysis	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	this	_	_	_	_	_	_	_	_
118	network	_	_	_	_	_	_	_	_
119	shows	_	_	_	_	_	_	_	_
120	that	_	_	_	_	_	_	_	BeginSeg=Yes
121	it	_	_	_	_	_	_	_	_
122	has	_	_	_	_	_	_	_	_
123	a	_	_	_	_	_	_	_	_
124	modular	_	_	_	_	_	_	_	_
125	scale	_	_	_	_	_	_	_	_
126	-	_	_	_	_	_	_	_	_
127	free	_	_	_	_	_	_	_	_
128	topology	_	_	_	_	_	_	_	_
129	in	_	_	_	_	_	_	_	BeginSeg=Yes
130	which	_	_	_	_	_	_	_	_
131	the	_	_	_	_	_	_	_	_
132	virus	_	_	_	_	_	_	_	_
133	proteins	_	_	_	_	_	_	_	_
134	orf8	_	_	_	_	_	_	_	_
135	,	_	_	_	_	_	_	_	_
136	M	_	_	_	_	_	_	_	_
137	,	_	_	_	_	_	_	_	_
138	and	_	_	_	_	_	_	_	_
139	Nsp7	_	_	_	_	_	_	_	_
140	are	_	_	_	_	_	_	_	_
141	the	_	_	_	_	_	_	_	_
142	three	_	_	_	_	_	_	_	_
143	nodes	_	_	_	_	_	_	_	_
144	with	_	_	_	_	_	_	_	_
145	the	_	_	_	_	_	_	_	_
146	most	_	_	_	_	_	_	_	_
147	connections	_	_	_	_	_	_	_	_
148	(	_	_	_	_	_	_	_	_
149	links	_	_	_	_	_	_	_	_
150	)	_	_	_	_	_	_	_	_
151	.	_	_	_	_	_	_	_	_
152	This	_	_	_	_	_	_	_	BeginSeg=Yes
153	result	_	_	_	_	_	_	_	_
154	suggests	_	_	_	_	_	_	_	_
155	the	_	_	_	_	_	_	_	_
156	possibility	_	_	_	_	_	_	_	_
157	that	_	_	_	_	_	_	_	BeginSeg=Yes
158	a	_	_	_	_	_	_	_	_
159	simultaneous	_	_	_	_	_	_	_	_
160	pharmacological	_	_	_	_	_	_	_	_
161	attack	_	_	_	_	_	_	_	_
162	on	_	_	_	_	_	_	_	_
163	these	_	_	_	_	_	_	_	_
164	hubs	_	_	_	_	_	_	_	_
165	could	_	_	_	_	_	_	_	_
166	assure	_	_	_	_	_	_	_	_
167	the	_	_	_	_	_	_	_	_
168	destruction	_	_	_	_	_	_	_	_
169	of	_	_	_	_	_	_	_	_
170	the	_	_	_	_	_	_	_	_
171	network	_	_	_	_	_	_	_	_
172	and	_	_	_	_	_	_	_	_
173	the	_	_	_	_	_	_	_	_
174	elimination	_	_	_	_	_	_	_	_
175	of	_	_	_	_	_	_	_	_
176	the	_	_	_	_	_	_	_	_
177	virus	_	_	_	_	_	_	_	_
178	.	_	_	_	_	_	_	_	_

# newdoc_id = 715bb1882a9b2b1bb0561bbd02a158f6deae2745
1	Viral	_	_	_	_	_	_	_	BeginSeg=Yes
2	influenza	_	_	_	_	_	_	_	_
3	is	_	_	_	_	_	_	_	_
4	a	_	_	_	_	_	_	_	_
5	seasonal	_	_	_	_	_	_	_	_
6	infection	_	_	_	_	_	_	_	_
7	associated	_	_	_	_	_	_	_	BeginSeg=Yes
8	with	_	_	_	_	_	_	_	_
9	significant	_	_	_	_	_	_	_	_
10	morbidity	_	_	_	_	_	_	_	_
11	and	_	_	_	_	_	_	_	_
12	mortality	_	_	_	_	_	_	_	_
13	.	_	_	_	_	_	_	_	_
14	In	_	_	_	_	_	_	_	BeginSeg=Yes
15	the	_	_	_	_	_	_	_	_
16	United	_	_	_	_	_	_	_	_
17	States	_	_	_	_	_	_	_	_
18	more	_	_	_	_	_	_	_	_
19	than	_	_	_	_	_	_	_	_
20	35,000	_	_	_	_	_	_	_	_
21	deaths	_	_	_	_	_	_	_	_
22	and	_	_	_	_	_	_	_	_
23	200,000	_	_	_	_	_	_	_	_
24	hospitalizations	_	_	_	_	_	_	_	_
25	due	_	_	_	_	_	_	_	BeginSeg=Yes
26	to	_	_	_	_	_	_	_	_
27	influenza	_	_	_	_	_	_	_	_
28	occur	_	_	_	_	_	_	_	BeginSeg=Yes
29	annually	_	_	_	_	_	_	_	_
30	,	_	_	_	_	_	_	_	_
31	and	_	_	_	_	_	_	_	BeginSeg=Yes
32	the	_	_	_	_	_	_	_	_
33	number	_	_	_	_	_	_	_	_
34	is	_	_	_	_	_	_	_	_
35	increasing	_	_	_	_	_	_	_	_
36	.	_	_	_	_	_	_	_	_
37	Children	_	_	_	_	_	_	_	BeginSeg=Yes
38	aged	_	_	_	_	_	_	_	BeginSeg=Yes
39	less	_	_	_	_	_	_	_	_
40	than	_	_	_	_	_	_	_	_
41	1	_	_	_	_	_	_	_	_
42	year	_	_	_	_	_	_	_	_
43	and	_	_	_	_	_	_	_	BeginSeg=Yes
44	adults	_	_	_	_	_	_	_	_
45	aged	_	_	_	_	_	_	_	BeginSeg=Yes
46	more	_	_	_	_	_	_	_	_
47	than	_	_	_	_	_	_	_	_
48	65	_	_	_	_	_	_	_	_
49	years	_	_	_	_	_	_	_	_
50	,	_	_	_	_	_	_	_	_
51	pregnant	_	_	_	_	_	_	_	BeginSeg=Yes
52	woman	_	_	_	_	_	_	_	_
53	,	_	_	_	_	_	_	_	_
54	and	_	_	_	_	_	_	_	_
55	people	_	_	_	_	_	_	_	_
56	of	_	_	_	_	_	_	_	_
57	any	_	_	_	_	_	_	_	_
58	age	_	_	_	_	_	_	_	_
59	with	_	_	_	_	_	_	_	_
60	comorbid	_	_	_	_	_	_	_	_
61	illnesses	_	_	_	_	_	_	_	_
62	are	_	_	_	_	_	_	_	_
63	at	_	_	_	_	_	_	_	_
64	highest	_	_	_	_	_	_	_	_
65	risk	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	Annual	_	_	_	_	_	_	_	BeginSeg=Yes
68	vaccination	_	_	_	_	_	_	_	_
69	is	_	_	_	_	_	_	_	_
70	the	_	_	_	_	_	_	_	_
71	cornerstone	_	_	_	_	_	_	_	_
72	of	_	_	_	_	_	_	_	_
73	prevention	_	_	_	_	_	_	_	_
74	,	_	_	_	_	_	_	_	_
75	but	_	_	_	_	_	_	_	BeginSeg=Yes
76	some	_	_	_	_	_	_	_	_
77	older	_	_	_	_	_	_	_	_
78	patients	_	_	_	_	_	_	_	_
79	may	_	_	_	_	_	_	_	_
80	derive	_	_	_	_	_	_	_	_
81	less	_	_	_	_	_	_	_	_
82	benefit	_	_	_	_	_	_	_	_
83	from	_	_	_	_	_	_	_	_
84	immunization	_	_	_	_	_	_	_	_
85	than	_	_	_	_	_	_	_	_
86	otherwise	_	_	_	_	_	_	_	_
87	fit	_	_	_	_	_	_	_	_
88	individuals	_	_	_	_	_	_	_	_
89	.	_	_	_	_	_	_	_	_
90	If	_	_	_	_	_	_	_	BeginSeg=Yes
91	started	_	_	_	_	_	_	_	_
92	promptly	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	antiviral	_	_	_	_	_	_	_	BeginSeg=Yes
95	medications	_	_	_	_	_	_	_	_
96	may	_	_	_	_	_	_	_	_
97	reduce	_	_	_	_	_	_	_	_
98	complications	_	_	_	_	_	_	_	_
99	of	_	_	_	_	_	_	_	_
100	acute	_	_	_	_	_	_	_	_
101	influenza	_	_	_	_	_	_	_	_
102	,	_	_	_	_	_	_	_	_
103	but	_	_	_	_	_	_	_	BeginSeg=Yes
104	increasing	_	_	_	_	_	_	_	_
105	resistance	_	_	_	_	_	_	_	_
106	to	_	_	_	_	_	_	_	_
107	amantadine	_	_	_	_	_	_	_	_
108	and	_	_	_	_	_	_	_	_
109	perhaps	_	_	_	_	_	_	_	_
110	neuraminidase	_	_	_	_	_	_	_	_
111	inhibitors	_	_	_	_	_	_	_	_
112	underscores	_	_	_	_	_	_	_	_
113	the	_	_	_	_	_	_	_	_
114	need	_	_	_	_	_	_	_	_
115	for	_	_	_	_	_	_	_	_
116	novel	_	_	_	_	_	_	_	_
117	prevention	_	_	_	_	_	_	_	_
118	and	_	_	_	_	_	_	_	_
119	treatment	_	_	_	_	_	_	_	_
120	strategies	_	_	_	_	_	_	_	_
121	.	_	_	_	_	_	_	_	_
122	Pulmonary	_	_	_	_	_	_	_	BeginSeg=Yes
123	complications	_	_	_	_	_	_	_	_
124	of	_	_	_	_	_	_	_	_
125	influenza	_	_	_	_	_	_	_	_
126	are	_	_	_	_	_	_	_	_
127	most	_	_	_	_	_	_	_	_
128	common	_	_	_	_	_	_	_	_
129	and	_	_	_	_	_	_	_	BeginSeg=Yes
130	include	_	_	_	_	_	_	_	_
131	primary	_	_	_	_	_	_	_	_
132	influenza	_	_	_	_	_	_	_	_
133	and	_	_	_	_	_	_	_	_
134	secondary	_	_	_	_	_	_	_	_
135	bacterial	_	_	_	_	_	_	_	_
136	infection	_	_	_	_	_	_	_	_
137	.	_	_	_	_	_	_	_	_
138	Either	_	_	_	_	_	_	_	BeginSeg=Yes
139	may	_	_	_	_	_	_	_	_
140	cause	_	_	_	_	_	_	_	_
141	pneumonia	_	_	_	_	_	_	_	_
142	,	_	_	_	_	_	_	_	_
143	and	_	_	_	_	_	_	_	BeginSeg=Yes
144	each	_	_	_	_	_	_	_	_
145	has	_	_	_	_	_	_	_	_
146	a	_	_	_	_	_	_	_	_
147	unique	_	_	_	_	_	_	_	_
148	clinical	_	_	_	_	_	_	_	_
149	presentation	_	_	_	_	_	_	_	_
150	and	_	_	_	_	_	_	_	_
151	pathologic	_	_	_	_	_	_	_	_
152	basis	_	_	_	_	_	_	_	_
153	.	_	_	_	_	_	_	_	_
154	Staphylococcus	_	_	_	_	_	_	_	BeginSeg=Yes
155	aureus	_	_	_	_	_	_	_	_
156	,	_	_	_	_	_	_	_	_
157	including	_	_	_	_	_	_	_	BeginSeg=Yes
158	methicillin	_	_	_	_	_	_	_	_
159	-	_	_	_	_	_	_	_	_
160	resistant	_	_	_	_	_	_	_	_
161	strains	_	_	_	_	_	_	_	_
162	,	_	_	_	_	_	_	_	_
163	is	_	_	_	_	_	_	_	BeginSeg=Yes
164	an	_	_	_	_	_	_	_	_
165	important	_	_	_	_	_	_	_	_
166	cause	_	_	_	_	_	_	_	_
167	of	_	_	_	_	_	_	_	_
168	secondary	_	_	_	_	_	_	_	_
169	bacterial	_	_	_	_	_	_	_	_
170	pneumonia	_	_	_	_	_	_	_	_
171	with	_	_	_	_	_	_	_	_
172	high	_	_	_	_	_	_	_	_
173	mortality	_	_	_	_	_	_	_	_
174	.	_	_	_	_	_	_	_	_
175	During	_	_	_	_	_	_	_	BeginSeg=Yes
176	influenza	_	_	_	_	_	_	_	_
177	season	_	_	_	_	_	_	_	_
178	,	_	_	_	_	_	_	_	_
179	treatment	_	_	_	_	_	_	_	_
180	of	_	_	_	_	_	_	_	_
181	pneumonia	_	_	_	_	_	_	_	_
182	should	_	_	_	_	_	_	_	_
183	include	_	_	_	_	_	_	_	_
184	empiric	_	_	_	_	_	_	_	_
185	coverage	_	_	_	_	_	_	_	_
186	for	_	_	_	_	_	_	_	_
187	this	_	_	_	_	_	_	_	_
188	pathogen	_	_	_	_	_	_	_	_
189	.	_	_	_	_	_	_	_	_
190	Neuromuscular	_	_	_	_	_	_	_	BeginSeg=Yes
191	and	_	_	_	_	_	_	_	_
192	cardiac	_	_	_	_	_	_	_	_
193	complications	_	_	_	_	_	_	_	_
194	are	_	_	_	_	_	_	_	_
195	unusual	_	_	_	_	_	_	_	_
196	but	_	_	_	_	_	_	_	BeginSeg=Yes
197	may	_	_	_	_	_	_	_	_
198	manifest	_	_	_	_	_	_	_	_
199	in	_	_	_	_	_	_	_	_
200	persons	_	_	_	_	_	_	_	_
201	of	_	_	_	_	_	_	_	_
202	any	_	_	_	_	_	_	_	_
203	age	_	_	_	_	_	_	_	_
204	.	_	_	_	_	_	_	_	_

# newdoc_id = 73924069b04d70bd1ef34a879ed7001f63c1111c
1	COVID-19	_	_	_	_	_	_	_	BeginSeg=Yes
2	has	_	_	_	_	_	_	_	_
3	emerged	_	_	_	_	_	_	_	_
4	as	_	_	_	_	_	_	_	_
5	global	_	_	_	_	_	_	_	_
6	medical	_	_	_	_	_	_	_	_
7	emergency	_	_	_	_	_	_	_	_
8	in	_	_	_	_	_	_	_	_
9	recentdecades	_	_	_	_	_	_	_	_
10	.	_	_	_	_	_	_	_	_
11	The	_	_	_	_	_	_	_	BeginSeg=Yes
12	spread	_	_	_	_	_	_	_	_
13	scenario	_	_	_	_	_	_	_	_
14	of	_	_	_	_	_	_	_	_
15	this	_	_	_	_	_	_	_	_
16	pandemic	_	_	_	_	_	_	_	_
17	has	_	_	_	_	_	_	_	_
18	shown	_	_	_	_	_	_	_	_
19	many	_	_	_	_	_	_	_	_
20	variations	_	_	_	_	_	_	_	_
21	.	_	_	_	_	_	_	_	_
22	Keeping	_	_	_	_	_	_	_	BeginSeg=Yes
23	all	_	_	_	_	_	_	_	_
24	this	_	_	_	_	_	_	_	_
25	in	_	_	_	_	_	_	_	_
26	mind	_	_	_	_	_	_	_	_
27	,	_	_	_	_	_	_	_	_
28	this	_	_	_	_	_	_	_	BeginSeg=Yes
29	article	_	_	_	_	_	_	_	_
30	is	_	_	_	_	_	_	_	_
31	written	_	_	_	_	_	_	_	_
32	after	_	_	_	_	_	_	_	_
33	various	_	_	_	_	_	_	_	_
34	studies	_	_	_	_	_	_	_	_
35	and	_	_	_	_	_	_	_	_
36	analysis	_	_	_	_	_	_	_	_
37	on	_	_	_	_	_	_	_	_
38	the	_	_	_	_	_	_	_	_
39	latest	_	_	_	_	_	_	_	_
40	data	_	_	_	_	_	_	_	_
41	on	_	_	_	_	_	_	_	_
42	COVID-19	_	_	_	_	_	_	_	_
43	spread	_	_	_	_	_	_	_	_
44	,	_	_	_	_	_	_	_	_
45	which	_	_	_	_	_	_	_	BeginSeg=Yes
46	also	_	_	_	_	_	_	_	_
47	includes	_	_	_	_	_	_	_	_
48	the	_	_	_	_	_	_	_	_
49	demographic	_	_	_	_	_	_	_	_
50	and	_	_	_	_	_	_	_	_
51	environmental	_	_	_	_	_	_	_	_
52	factors	_	_	_	_	_	_	_	_
53	.	_	_	_	_	_	_	_	_
54	After	_	_	_	_	_	_	_	BeginSeg=Yes
55	gathering	_	_	_	_	_	_	_	_
56	data	_	_	_	_	_	_	_	_
57	from	_	_	_	_	_	_	_	_
58	various	_	_	_	_	_	_	_	_
59	resources	_	_	_	_	_	_	_	_
60	,	_	_	_	_	_	_	_	_
61	all	_	_	_	_	_	_	_	BeginSeg=Yes
62	data	_	_	_	_	_	_	_	_
63	are	_	_	_	_	_	_	_	_
64	integrated	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	_
66	passed	_	_	_	_	_	_	_	_
67	into	_	_	_	_	_	_	_	_
68	different	_	_	_	_	_	_	_	_
69	Machine	_	_	_	_	_	_	_	_
70	Learning	_	_	_	_	_	_	_	_
71	Models	_	_	_	_	_	_	_	_
72	to	_	_	_	_	_	_	_	BeginSeg=Yes
73	check	_	_	_	_	_	_	_	_
74	the	_	_	_	_	_	_	_	_
75	fit	_	_	_	_	_	_	_	_
76	.	_	_	_	_	_	_	_	_
77	Ensemble	_	_	_	_	_	_	_	BeginSeg=Yes
78	Learning	_	_	_	_	_	_	_	_
79	Technique	_	_	_	_	_	_	_	_
80	,	_	_	_	_	_	_	_	_
81	Random	_	_	_	_	_	_	_	_
82	Forest	_	_	_	_	_	_	_	_
83	,	_	_	_	_	_	_	_	_
84	gives	_	_	_	_	_	_	_	_
85	a	_	_	_	_	_	_	_	_
86	good	_	_	_	_	_	_	_	_
87	evaluation	_	_	_	_	_	_	_	_
88	score	_	_	_	_	_	_	_	_
89	on	_	_	_	_	_	_	_	_
90	the	_	_	_	_	_	_	_	_
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59	situations	_	_	_	_	_	_	_	_
60	,	_	_	_	_	_	_	_	_
61	such	_	_	_	_	_	_	_	BeginSeg=Yes
62	as	_	_	_	_	_	_	_	_
63	severe	_	_	_	_	_	_	_	_
64	acute	_	_	_	_	_	_	_	_
65	respiratory	_	_	_	_	_	_	_	_
66	syndrome	_	_	_	_	_	_	_	_
67	(	_	_	_	_	_	_	_	_
68	SARS	_	_	_	_	_	_	_	_
69	)	_	_	_	_	_	_	_	_
70	,	_	_	_	_	_	_	_	_
71	influenza	_	_	_	_	_	_	_	_
72	A	_	_	_	_	_	_	_	_
73	(	_	_	_	_	_	_	_	_
74	H1N1	_	_	_	_	_	_	_	_
75	)	_	_	_	_	_	_	_	_
76	,	_	_	_	_	_	_	_	_
77	avian	_	_	_	_	_	_	_	_
78	influenza	_	_	_	_	_	_	_	_
79	H5N1	_	_	_	_	_	_	_	_
80	and	_	_	_	_	_	_	_	_
81	H7N9	_	_	_	_	_	_	_	_
82	,	_	_	_	_	_	_	_	_
83	and	_	_	_	_	_	_	_	_
84	Ebola	_	_	_	_	_	_	_	_
85	hemorrhagic	_	_	_	_	_	_	_	_
86	fever	_	_	_	_	_	_	_	_
87	,	_	_	_	_	_	_	_	_
88	while	_	_	_	_	_	_	_	BeginSeg=Yes
89	actively	_	_	_	_	_	_	_	_
90	maintained	_	_	_	_	_	_	_	_
91	public	_	_	_	_	_	_	_	_
92	health	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	economic	_	_	_	_	_	_	_	_
95	development	_	_	_	_	_	_	_	_
96	,	_	_	_	_	_	_	_	_
97	and	_	_	_	_	_	_	_	_
98	national	_	_	_	_	_	_	_	_
99	construction	_	_	_	_	_	_	_	_
100	.	_	_	_	_	_	_	_	_
101	This	_	_	_	_	_	_	_	BeginSeg=Yes
102	paper	_	_	_	_	_	_	_	_
103	focuses	_	_	_	_	_	_	_	_
104	on	_	_	_	_	_	_	_	_
105	the	_	_	_	_	_	_	_	_
106	mechanisms	_	_	_	_	_	_	_	_
107	of	_	_	_	_	_	_	_	_
108	the	_	_	_	_	_	_	_	_
109	military	_	_	_	_	_	_	_	_
110	-	_	_	_	_	_	_	_	_
111	cooperative	_	_	_	_	_	_	_	_
112	emergency	_	_	_	_	_	_	_	_
113	response	_	_	_	_	_	_	_	_
114	to	_	_	_	_	_	_	_	_
115	infectious	_	_	_	_	_	_	_	_
116	diseases	_	_	_	_	_	_	_	_
117	-	_	_	_	_	_	_	_	BeginSeg=Yes
118	the	_	_	_	_	_	_	_	_
119	joint	_	_	_	_	_	_	_	_
120	working	_	_	_	_	_	_	_	_
121	mechanism	_	_	_	_	_	_	_	_
122	,	_	_	_	_	_	_	_	_
123	the	_	_	_	_	_	_	_	_
124	information	_	_	_	_	_	_	_	_
125	-	_	_	_	_	_	_	_	_
126	sharing	_	_	_	_	_	_	_	_
127	mechanism	_	_	_	_	_	_	_	_
128	,	_	_	_	_	_	_	_	_
129	the	_	_	_	_	_	_	_	_
130	research	_	_	_	_	_	_	_	_
131	collaboration	_	_	_	_	_	_	_	_
132	mechanism	_	_	_	_	_	_	_	_
133	,	_	_	_	_	_	_	_	_
134	and	_	_	_	_	_	_	_	_
135	the	_	_	_	_	_	_	_	_
136	joint	_	_	_	_	_	_	_	_
137	disposal	_	_	_	_	_	_	_	_
138	mechanism	_	_	_	_	_	_	_	_
139	-	_	_	_	_	_	_	_	_
140	and	_	_	_	_	_	_	_	BeginSeg=Yes
141	presents	_	_	_	_	_	_	_	_
142	a	_	_	_	_	_	_	_	_
143	sorted	_	_	_	_	_	_	_	_
144	summary	_	_	_	_	_	_	_	_
145	of	_	_	_	_	_	_	_	_
146	the	_	_	_	_	_	_	_	_
147	practices	_	_	_	_	_	_	_	_
148	and	_	_	_	_	_	_	_	_
149	experiences	_	_	_	_	_	_	_	_
150	of	_	_	_	_	_	_	_	_
151	cooperative	_	_	_	_	_	_	_	_
152	emergency	_	_	_	_	_	_	_	_
153	responses	_	_	_	_	_	_	_	_
154	to	_	_	_	_	_	_	_	_
155	infectious	_	_	_	_	_	_	_	_
156	diseases	_	_	_	_	_	_	_	_
157	.	_	_	_	_	_	_	_	_
158	In	_	_	_	_	_	_	_	BeginSeg=Yes
159	the	_	_	_	_	_	_	_	_
160	future	_	_	_	_	_	_	_	_
161	,	_	_	_	_	_	_	_	_
162	the	_	_	_	_	_	_	_	_
163	Chinese	_	_	_	_	_	_	_	_
164	military	_	_	_	_	_	_	_	_
165	and	_	_	_	_	_	_	_	_
166	the	_	_	_	_	_	_	_	_
167	civilian	_	_	_	_	_	_	_	_
168	sector	_	_	_	_	_	_	_	_
169	will	_	_	_	_	_	_	_	_
170	further	_	_	_	_	_	_	_	_
171	strengthen	_	_	_	_	_	_	_	_
172	the	_	_	_	_	_	_	_	_
173	cooperative	_	_	_	_	_	_	_	_
174	joint	_	_	_	_	_	_	_	_
175	command	_	_	_	_	_	_	_	_
176	system	_	_	_	_	_	_	_	_
177	and	_	_	_	_	_	_	_	_
178	emergency	_	_	_	_	_	_	_	_
179	rescue	_	_	_	_	_	_	_	_
180	force	_	_	_	_	_	_	_	_
181	and	_	_	_	_	_	_	_	BeginSeg=Yes
182	will	_	_	_	_	_	_	_	_
183	reinforce	_	_	_	_	_	_	_	_
184	their	_	_	_	_	_	_	_	_
185	collaborative	_	_	_	_	_	_	_	_
186	information	_	_	_	_	_	_	_	_
187	-	_	_	_	_	_	_	_	_
188	sharing	_	_	_	_	_	_	_	_
189	platform	_	_	_	_	_	_	_	_
190	and	_	_	_	_	_	_	_	_
191	technical	_	_	_	_	_	_	_	_
192	equipment	_	_	_	_	_	_	_	_
193	system	_	_	_	_	_	_	_	_
194	to	_	_	_	_	_	_	_	BeginSeg=Yes
195	further	_	_	_	_	_	_	_	_
196	improve	_	_	_	_	_	_	_	_
197	military	_	_	_	_	_	_	_	_
198	-	_	_	_	_	_	_	_	_
199	civilian	_	_	_	_	_	_	_	_
200	collaborative	_	_	_	_	_	_	_	_
201	emergency	_	_	_	_	_	_	_	_
202	infectious	_	_	_	_	_	_	_	_
203	diseases	_	_	_	_	_	_	_	_
204	disposal	_	_	_	_	_	_	_	_
205	,	_	_	_	_	_	_	_	_
206	advance	_	_	_	_	_	_	_	BeginSeg=Yes
207	the	_	_	_	_	_	_	_	_
208	level	_	_	_	_	_	_	_	_
209	of	_	_	_	_	_	_	_	_
210	infectious	_	_	_	_	_	_	_	_
211	disease	_	_	_	_	_	_	_	_
212	prevention	_	_	_	_	_	_	_	_
213	and	_	_	_	_	_	_	_	_
214	control	_	_	_	_	_	_	_	_
215	,	_	_	_	_	_	_	_	_
216	and	_	_	_	_	_	_	_	BeginSeg=Yes
217	maintain	_	_	_	_	_	_	_	_
218	public	_	_	_	_	_	_	_	_
219	health	_	_	_	_	_	_	_	_
220	.	_	_	_	_	_	_	_	_

# newdoc_id = 7ff1d5c7e68d082ee1f2e6fdfbb6ae1ff931e0db
1	COVID-19	_	_	_	_	_	_	_	BeginSeg=Yes
2	can	_	_	_	_	_	_	_	_
3	affect	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	hematopoietic	_	_	_	_	_	_	_	_
6	system	_	_	_	_	_	_	_	_
7	.	_	_	_	_	_	_	_	_
8	Thrombocytopenia	_	_	_	_	_	_	_	BeginSeg=Yes
9	at	_	_	_	_	_	_	_	_
10	admission	_	_	_	_	_	_	_	_
11	was	_	_	_	_	_	_	_	_
12	prevalent	_	_	_	_	_	_	_	_
13	,	_	_	_	_	_	_	_	_
14	while	_	_	_	_	_	_	_	BeginSeg=Yes
15	late	_	_	_	_	_	_	_	_
16	-	_	_	_	_	_	_	_	_
17	phase	_	_	_	_	_	_	_	_
18	or	_	_	_	_	_	_	_	_
19	delayed	_	_	_	_	_	_	_	_
20	-	_	_	_	_	_	_	_	_
21	phase	_	_	_	_	_	_	_	_
22	thrombocytopenia	_	_	_	_	_	_	_	_
23	(	_	_	_	_	_	_	_	BeginSeg=Yes
24	occurred	_	_	_	_	_	_	_	_
25	14	_	_	_	_	_	_	_	_
26	days	_	_	_	_	_	_	_	_
27	after	_	_	_	_	_	_	_	_
28	symptom	_	_	_	_	_	_	_	_
29	onset	_	_	_	_	_	_	_	_
30	)	_	_	_	_	_	_	_	_
31	is	_	_	_	_	_	_	_	BeginSeg=Yes
32	obscure	_	_	_	_	_	_	_	_
33	.	_	_	_	_	_	_	_	_
34	This	_	_	_	_	_	_	_	BeginSeg=Yes
35	retrospective	_	_	_	_	_	_	_	_
36	single	_	_	_	_	_	_	_	_
37	-	_	_	_	_	_	_	_	_
38	center	_	_	_	_	_	_	_	_
39	study	_	_	_	_	_	_	_	_
40	screened	_	_	_	_	_	_	_	_
41	450	_	_	_	_	_	_	_	_
42	COVID-19	_	_	_	_	_	_	_	_
43	patients	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	BeginSeg=Yes
45	enrolled	_	_	_	_	_	_	_	_
46	271	_	_	_	_	_	_	_	_
47	patients	_	_	_	_	_	_	_	_
48	at	_	_	_	_	_	_	_	_
49	the	_	_	_	_	_	_	_	_
50	Union	_	_	_	_	_	_	_	_
51	Hospital	_	_	_	_	_	_	_	_
52	,	_	_	_	_	_	_	_	_
53	Wuhan	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	China	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	from	_	_	_	_	_	_	_	_
58	January	_	_	_	_	_	_	_	_
59	25th	_	_	_	_	_	_	_	_
60	to	_	_	_	_	_	_	_	_
61	March	_	_	_	_	_	_	_	_
62	9th	_	_	_	_	_	_	_	_
63	,	_	_	_	_	_	_	_	_
64	2020	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
66	COVID-19	_	_	_	_	_	_	_	BeginSeg=Yes
67	associated	_	_	_	_	_	_	_	_
68	delayed	_	_	_	_	_	_	_	_
69	-	_	_	_	_	_	_	_	_
70	phase	_	_	_	_	_	_	_	_
71	thrombocytopenia	_	_	_	_	_	_	_	_
72	occurred	_	_	_	_	_	_	_	_
73	in	_	_	_	_	_	_	_	_
74	11.8	_	_	_	_	_	_	_	_
75	%	_	_	_	_	_	_	_	_
76	percent	_	_	_	_	_	_	_	_
77	of	_	_	_	_	_	_	_	_
78	enrolling	_	_	_	_	_	_	_	_
79	patients	_	_	_	_	_	_	_	_
80	.	_	_	_	_	_	_	_	_
81	The	_	_	_	_	_	_	_	BeginSeg=Yes
82	delayed	_	_	_	_	_	_	_	_
83	-	_	_	_	_	_	_	_	_
84	phase	_	_	_	_	_	_	_	_
85	thrombocytopenia	_	_	_	_	_	_	_	_
86	in	_	_	_	_	_	_	_	_
87	COVID-19	_	_	_	_	_	_	_	_
88	is	_	_	_	_	_	_	_	_
89	prone	_	_	_	_	_	_	_	_
90	to	_	_	_	_	_	_	_	_
91	develop	_	_	_	_	_	_	_	_
92	in	_	_	_	_	_	_	_	_
93	elderly	_	_	_	_	_	_	_	_
94	patients	_	_	_	_	_	_	_	_
95	or	_	_	_	_	_	_	_	_
96	patients	_	_	_	_	_	_	_	_
97	with	_	_	_	_	_	_	_	_
98	low	_	_	_	_	_	_	_	_
99	lymphocyte	_	_	_	_	_	_	_	_
100	count	_	_	_	_	_	_	_	_
101	on	_	_	_	_	_	_	_	_
102	admission	_	_	_	_	_	_	_	_
103	.	_	_	_	_	_	_	_	_
104	The	_	_	_	_	_	_	_	BeginSeg=Yes
105	delayed	_	_	_	_	_	_	_	_
106	-	_	_	_	_	_	_	_	_
107	phase	_	_	_	_	_	_	_	_
108	thrombocytopenia	_	_	_	_	_	_	_	_
109	is	_	_	_	_	_	_	_	_
110	significantly	_	_	_	_	_	_	_	_
111	associated	_	_	_	_	_	_	_	_
112	with	_	_	_	_	_	_	_	_
113	increased	_	_	_	_	_	_	_	_
114	length	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	hospital	_	_	_	_	_	_	_	_
117	stay	_	_	_	_	_	_	_	_
118	and	_	_	_	_	_	_	_	_
119	higher	_	_	_	_	_	_	_	_
120	mortality	_	_	_	_	_	_	_	_
121	rate	_	_	_	_	_	_	_	_
122	.	_	_	_	_	_	_	_	_
123	Delayed	_	_	_	_	_	_	_	BeginSeg=Yes
124	-	_	_	_	_	_	_	_	_
125	phase	_	_	_	_	_	_	_	_
126	nadir	_	_	_	_	_	_	_	_
127	platelet	_	_	_	_	_	_	_	_
128	counts	_	_	_	_	_	_	_	_
129	demonstrated	_	_	_	_	_	_	_	_
130	a	_	_	_	_	_	_	_	_
131	significantly	_	_	_	_	_	_	_	_
132	negative	_	_	_	_	_	_	_	_
133	correlation	_	_	_	_	_	_	_	_
134	with	_	_	_	_	_	_	_	_
135	B	_	_	_	_	_	_	_	_
136	cell	_	_	_	_	_	_	_	_
137	percentages	_	_	_	_	_	_	_	_
138	.	_	_	_	_	_	_	_	_
139	We	_	_	_	_	_	_	_	BeginSeg=Yes
140	also	_	_	_	_	_	_	_	_
141	presented	_	_	_	_	_	_	_	_
142	bone	_	_	_	_	_	_	_	_
143	marrow	_	_	_	_	_	_	_	_
144	aspiration	_	_	_	_	_	_	_	_
145	pathology	_	_	_	_	_	_	_	_
146	of	_	_	_	_	_	_	_	_
147	three	_	_	_	_	_	_	_	_
148	patients	_	_	_	_	_	_	_	_
149	with	_	_	_	_	_	_	_	_
150	delayed	_	_	_	_	_	_	_	_
151	-	_	_	_	_	_	_	_	_
152	phase	_	_	_	_	_	_	_	_
153	thrombocytopenia	_	_	_	_	_	_	_	_
154	,	_	_	_	_	_	_	_	_
155	showing	_	_	_	_	_	_	_	BeginSeg=Yes
156	impaired	_	_	_	_	_	_	_	_
157	maturation	_	_	_	_	_	_	_	_
158	of	_	_	_	_	_	_	_	_
159	megakaryocytes	_	_	_	_	_	_	_	_
160	.	_	_	_	_	_	_	_	_
161	We	_	_	_	_	_	_	_	BeginSeg=Yes
162	speculated	_	_	_	_	_	_	_	_
163	that	_	_	_	_	_	_	_	BeginSeg=Yes
164	immune	_	_	_	_	_	_	_	_
165	mediated	_	_	_	_	_	_	_	_
166	platelet	_	_	_	_	_	_	_	_
167	destruction	_	_	_	_	_	_	_	_
168	might	_	_	_	_	_	_	_	_
169	account	_	_	_	_	_	_	_	_
170	for	_	_	_	_	_	_	_	_
171	the	_	_	_	_	_	_	_	_
172	delayed	_	_	_	_	_	_	_	_
173	-	_	_	_	_	_	_	_	_
174	phase	_	_	_	_	_	_	_	_
175	thrombocytopenia	_	_	_	_	_	_	_	_
176	in	_	_	_	_	_	_	_	_
177	a	_	_	_	_	_	_	_	_
178	group	_	_	_	_	_	_	_	_
179	of	_	_	_	_	_	_	_	_
180	patients	_	_	_	_	_	_	_	_
181	.	_	_	_	_	_	_	_	_
182	Besides	_	_	_	_	_	_	_	BeginSeg=Yes
183	,	_	_	_	_	_	_	_	_
184	clinicians	_	_	_	_	_	_	_	_
185	need	_	_	_	_	_	_	_	_
186	to	_	_	_	_	_	_	_	_
187	pay	_	_	_	_	_	_	_	_
188	attention	_	_	_	_	_	_	_	_
189	to	_	_	_	_	_	_	_	_
190	the	_	_	_	_	_	_	_	_
191	delayed	_	_	_	_	_	_	_	_
192	-	_	_	_	_	_	_	_	_
193	phase	_	_	_	_	_	_	_	_
194	thrombocytopenia	_	_	_	_	_	_	_	_
195	especially	_	_	_	_	_	_	_	_
196	at	_	_	_	_	_	_	_	_
197	3	_	_	_	_	_	_	_	_
198	-	_	_	_	_	_	_	_	_
199	4	_	_	_	_	_	_	_	_
200	weeks	_	_	_	_	_	_	_	_
201	after	_	_	_	_	_	_	_	_
202	symptom	_	_	_	_	_	_	_	_
203	onset	_	_	_	_	_	_	_	_
204	.	_	_	_	_	_	_	_	_

# newdoc_id = 8edf35c1ee0ae65d00ecd1d87b98f48bcce861ee
1	Mortality	_	_	_	_	_	_	_	BeginSeg=Yes
2	from	_	_	_	_	_	_	_	_
3	coronavirus	_	_	_	_	_	_	_	_
4	disease	_	_	_	_	_	_	_	_
5	2019	_	_	_	_	_	_	_	_
6	is	_	_	_	_	_	_	_	_
7	strongly	_	_	_	_	_	_	_	_
8	associated	_	_	_	_	_	_	_	_
9	with	_	_	_	_	_	_	_	_
10	cardiovascular	_	_	_	_	_	_	_	_
11	disease	_	_	_	_	_	_	_	_
12	,	_	_	_	_	_	_	_	_
13	diabetes	_	_	_	_	_	_	_	_
14	,	_	_	_	_	_	_	_	_
15	and	_	_	_	_	_	_	_	_
16	hypertension	_	_	_	_	_	_	_	_
17	.	_	_	_	_	_	_	_	_
18	These	_	_	_	_	_	_	_	BeginSeg=Yes
19	disorders	_	_	_	_	_	_	_	_
20	share	_	_	_	_	_	_	_	_
21	underlying	_	_	_	_	_	_	_	_
22	pathophysiology	_	_	_	_	_	_	_	_
23	related	_	_	_	_	_	_	_	BeginSeg=Yes
24	to	_	_	_	_	_	_	_	_
25	the	_	_	_	_	_	_	_	_
26	renin	_	_	_	_	_	_	_	_
27	-	_	_	_	_	_	_	_	_
28	angiotensin	_	_	_	_	_	_	_	_
29	system	_	_	_	_	_	_	_	_
30	(	_	_	_	_	_	_	_	_
31	RAS	_	_	_	_	_	_	_	_
32	)	_	_	_	_	_	_	_	_
33	that	_	_	_	_	_	_	_	BeginSeg=Yes
34	may	_	_	_	_	_	_	_	_
35	be	_	_	_	_	_	_	_	_
36	clinically	_	_	_	_	_	_	_	_
37	insightful	_	_	_	_	_	_	_	_
38	.	_	_	_	_	_	_	_	_
39	In	_	_	_	_	_	_	_	BeginSeg=Yes
40	particular	_	_	_	_	_	_	_	_
41	,	_	_	_	_	_	_	_	_
42	activity	_	_	_	_	_	_	_	_
43	of	_	_	_	_	_	_	_	_
44	the	_	_	_	_	_	_	_	_
45	angiotensin	_	_	_	_	_	_	_	_
46	-	_	_	_	_	_	_	_	_
47	converting	_	_	_	_	_	_	_	_
48	enzyme	_	_	_	_	_	_	_	_
49	2	_	_	_	_	_	_	_	_
50	(	_	_	_	_	_	_	_	_
51	ACE2	_	_	_	_	_	_	_	_
52	)	_	_	_	_	_	_	_	_
53	is	_	_	_	_	_	_	_	_
54	dysregulated	_	_	_	_	_	_	_	_
55	in	_	_	_	_	_	_	_	_
56	cardiovascular	_	_	_	_	_	_	_	_
57	disease	_	_	_	_	_	_	_	_
58	,	_	_	_	_	_	_	_	_
59	and	_	_	_	_	_	_	_	BeginSeg=Yes
60	this	_	_	_	_	_	_	_	_
61	enzyme	_	_	_	_	_	_	_	_
62	is	_	_	_	_	_	_	_	_
63	used	_	_	_	_	_	_	_	_
64	by	_	_	_	_	_	_	_	_
65	severe	_	_	_	_	_	_	_	_
66	acute	_	_	_	_	_	_	_	_
67	respiratory	_	_	_	_	_	_	_	_
68	syndrome	_	_	_	_	_	_	_	_
69	coronavirus	_	_	_	_	_	_	_	_
70	2	_	_	_	_	_	_	_	_
71	(	_	_	_	_	_	_	_	_
72	SARS	_	_	_	_	_	_	_	_
73	-	_	_	_	_	_	_	_	_
74	CoV-2	_	_	_	_	_	_	_	_
75	)	_	_	_	_	_	_	_	_
76	to	_	_	_	_	_	_	_	BeginSeg=Yes
77	initiate	_	_	_	_	_	_	_	_
78	the	_	_	_	_	_	_	_	_
79	infection	_	_	_	_	_	_	_	_
80	.	_	_	_	_	_	_	_	_
81	Cardiovascular	_	_	_	_	_	_	_	BeginSeg=Yes
82	disease	_	_	_	_	_	_	_	_
83	and	_	_	_	_	_	_	_	_
84	pharmacologic	_	_	_	_	_	_	_	_
85	RAS	_	_	_	_	_	_	_	_
86	inhibition	_	_	_	_	_	_	_	_
87	both	_	_	_	_	_	_	_	_
88	increase	_	_	_	_	_	_	_	_
89	ACE2	_	_	_	_	_	_	_	_
90	levels	_	_	_	_	_	_	_	_
91	,	_	_	_	_	_	_	_	_
92	which	_	_	_	_	_	_	_	BeginSeg=Yes
93	may	_	_	_	_	_	_	_	_
94	increase	_	_	_	_	_	_	_	_
95	the	_	_	_	_	_	_	_	_
96	virulence	_	_	_	_	_	_	_	_
97	of	_	_	_	_	_	_	_	_
98	SARS	_	_	_	_	_	_	_	_
99	-	_	_	_	_	_	_	_	_
100	CoV-2	_	_	_	_	_	_	_	_
101	within	_	_	_	_	_	_	_	_
102	the	_	_	_	_	_	_	_	_
103	lung	_	_	_	_	_	_	_	_
104	and	_	_	_	_	_	_	_	_
105	heart	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	Conversely	_	_	_	_	_	_	_	BeginSeg=Yes
108	,	_	_	_	_	_	_	_	_
109	mechanistic	_	_	_	_	_	_	_	_
110	evidence	_	_	_	_	_	_	_	_
111	from	_	_	_	_	_	_	_	_
112	related	_	_	_	_	_	_	_	_
113	coronaviruses	_	_	_	_	_	_	_	_
114	suggests	_	_	_	_	_	_	_	_
115	that	_	_	_	_	_	_	_	BeginSeg=Yes
116	SARS	_	_	_	_	_	_	_	_
117	-	_	_	_	_	_	_	_	_
118	CoV-2	_	_	_	_	_	_	_	_
119	infection	_	_	_	_	_	_	_	_
120	may	_	_	_	_	_	_	_	_
121	downregulate	_	_	_	_	_	_	_	_
122	ACE2	_	_	_	_	_	_	_	_
123	,	_	_	_	_	_	_	_	_
124	leading	_	_	_	_	_	_	_	BeginSeg=Yes
125	to	_	_	_	_	_	_	_	_
126	toxic	_	_	_	_	_	_	_	_
127	overaccumulation	_	_	_	_	_	_	_	_
128	of	_	_	_	_	_	_	_	_
129	Angiotensin	_	_	_	_	_	_	_	_
130	II	_	_	_	_	_	_	_	_
131	that	_	_	_	_	_	_	_	BeginSeg=Yes
132	induces	_	_	_	_	_	_	_	_
133	acute	_	_	_	_	_	_	_	_
134	respiratory	_	_	_	_	_	_	_	_
135	distress	_	_	_	_	_	_	_	_
136	syndrome	_	_	_	_	_	_	_	_
137	and	_	_	_	_	_	_	_	_
138	fulminant	_	_	_	_	_	_	_	_
139	myocarditis	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	RAS	_	_	_	_	_	_	_	BeginSeg=Yes
142	inhibition	_	_	_	_	_	_	_	_
143	could	_	_	_	_	_	_	_	_
144	mitigate	_	_	_	_	_	_	_	_
145	this	_	_	_	_	_	_	_	_
146	effect	_	_	_	_	_	_	_	_
147	.	_	_	_	_	_	_	_	_
148	With	_	_	_	_	_	_	_	BeginSeg=Yes
149	conflicting	_	_	_	_	_	_	_	_
150	mechanistic	_	_	_	_	_	_	_	_
151	evidence	_	_	_	_	_	_	_	_
152	,	_	_	_	_	_	_	_	_
153	we	_	_	_	_	_	_	_	_
154	propose	_	_	_	_	_	_	_	_
155	key	_	_	_	_	_	_	_	_
156	clinical	_	_	_	_	_	_	_	_
157	research	_	_	_	_	_	_	_	_
158	priorities	_	_	_	_	_	_	_	_
159	necessary	_	_	_	_	_	_	_	BeginSeg=Yes
160	to	_	_	_	_	_	_	_	_
161	clarify	_	_	_	_	_	_	_	_
162	the	_	_	_	_	_	_	_	_
163	role	_	_	_	_	_	_	_	_
164	of	_	_	_	_	_	_	_	_
165	RAS	_	_	_	_	_	_	_	_
166	inhibition	_	_	_	_	_	_	_	_
167	in	_	_	_	_	_	_	_	_
168	COVID-19	_	_	_	_	_	_	_	_
169	mortality	_	_	_	_	_	_	_	_
170	that	_	_	_	_	_	_	_	BeginSeg=Yes
171	could	_	_	_	_	_	_	_	_
172	be	_	_	_	_	_	_	_	_
173	rapidly	_	_	_	_	_	_	_	_
174	addressed	_	_	_	_	_	_	_	_
175	by	_	_	_	_	_	_	_	_
176	the	_	_	_	_	_	_	_	_
177	international	_	_	_	_	_	_	_	_
178	research	_	_	_	_	_	_	_	_
179	community	_	_	_	_	_	_	_	_
180	.	_	_	_	_	_	_	_	_

# newdoc_id = 986a03b193e684ba1acfbc5f275bd7935b3507ec
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2	by	_	_	_	_	_	_	_	_
3	the	_	_	_	_	_	_	_	_
4	covid-19	_	_	_	_	_	_	_	_
5	pandemic	_	_	_	_	_	_	_	_
6	,	_	_	_	_	_	_	_	_
7	we	_	_	_	_	_	_	_	BeginSeg=Yes
8	developed	_	_	_	_	_	_	_	_
9	a	_	_	_	_	_	_	_	_
10	novel	_	_	_	_	_	_	_	_
11	Shewhart	_	_	_	_	_	_	_	_
12	chart	_	_	_	_	_	_	_	_
13	to	_	_	_	_	_	_	_	BeginSeg=Yes
14	visualize	_	_	_	_	_	_	_	_
15	and	_	_	_	_	_	_	_	_
16	learn	_	_	_	_	_	_	_	_
17	from	_	_	_	_	_	_	_	_
18	variation	_	_	_	_	_	_	_	_
19	in	_	_	_	_	_	_	_	_
20	reported	_	_	_	_	_	_	_	_
21	deaths	_	_	_	_	_	_	_	_
22	in	_	_	_	_	_	_	_	_
23	an	_	_	_	_	_	_	_	_
24	epidemic	_	_	_	_	_	_	_	_
25	.	_	_	_	_	_	_	_	_
26	Without	_	_	_	_	_	_	_	BeginSeg=Yes
27	a	_	_	_	_	_	_	_	_
28	method	_	_	_	_	_	_	_	_
29	to	_	_	_	_	_	_	_	BeginSeg=Yes
30	understand	_	_	_	_	_	_	_	_
31	if	_	_	_	_	_	_	_	_
32	day	_	_	_	_	_	_	_	_
33	-	_	_	_	_	_	_	_	_
34	to	_	_	_	_	_	_	_	_
35	-	_	_	_	_	_	_	_	_
36	day	_	_	_	_	_	_	_	_
37	variation	_	_	_	_	_	_	_	_
38	in	_	_	_	_	_	_	_	_
39	outcomes	_	_	_	_	_	_	_	_
40	may	_	_	_	_	_	_	_	_
41	be	_	_	_	_	_	_	_	_
42	attributed	_	_	_	_	_	_	_	_
43	to	_	_	_	_	_	_	_	_
44	meaningful	_	_	_	_	_	_	_	_
45	signals	_	_	_	_	_	_	_	_
46	of	_	_	_	_	_	_	_	_
47	change	_	_	_	_	_	_	_	_
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49	rather	_	_	_	_	_	_	_	_
50	than	_	_	_	_	_	_	_	_
51	variability	_	_	_	_	_	_	_	_
52	we	_	_	_	_	_	_	_	_
53	would	_	_	_	_	_	_	_	_
54	expect	_	_	_	_	_	_	_	_
55	-	_	_	_	_	_	_	_	_
56	care	_	_	_	_	_	_	_	BeginSeg=Yes
57	providers	_	_	_	_	_	_	_	_
58	,	_	_	_	_	_	_	_	_
59	improvement	_	_	_	_	_	_	_	_
60	leaders	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	policy	_	_	_	_	_	_	_	_
63	-	_	_	_	_	_	_	_	_
64	makers	_	_	_	_	_	_	_	_
65	,	_	_	_	_	_	_	_	_
66	and	_	_	_	_	_	_	_	_
67	the	_	_	_	_	_	_	_	_
68	public	_	_	_	_	_	_	_	_
69	will	_	_	_	_	_	_	_	_
70	struggle	_	_	_	_	_	_	_	_
71	to	_	_	_	_	_	_	_	_
72	recognize	_	_	_	_	_	_	_	_
73	if	_	_	_	_	_	_	_	_
74	epidemic	_	_	_	_	_	_	_	_
75	conditions	_	_	_	_	_	_	_	_
76	are	_	_	_	_	_	_	_	_
77	improving	_	_	_	_	_	_	_	_
78	.	_	_	_	_	_	_	_	_
79	We	_	_	_	_	_	_	_	BeginSeg=Yes
80	developed	_	_	_	_	_	_	_	_
81	a	_	_	_	_	_	_	_	_
82	novel	_	_	_	_	_	_	_	_
83	hybrid	_	_	_	_	_	_	_	_
84	C	_	_	_	_	_	_	_	_
85	-	_	_	_	_	_	_	_	_
86	Chart	_	_	_	_	_	_	_	_
87	and	_	_	_	_	_	_	_	_
88	I	_	_	_	_	_	_	_	_
89	-	_	_	_	_	_	_	_	_
90	Chart	_	_	_	_	_	_	_	_
91	to	_	_	_	_	_	_	_	BeginSeg=Yes
92	detect	_	_	_	_	_	_	_	_
93	within	_	_	_	_	_	_	_	_
94	a	_	_	_	_	_	_	_	_
95	geographic	_	_	_	_	_	_	_	_
96	area	_	_	_	_	_	_	_	_
97	the	_	_	_	_	_	_	_	_
98	start	_	_	_	_	_	_	_	_
99	and	_	_	_	_	_	_	_	_
100	end	_	_	_	_	_	_	_	_
101	of	_	_	_	_	_	_	_	_
102	exponential	_	_	_	_	_	_	_	_
103	growth	_	_	_	_	_	_	_	_
104	in	_	_	_	_	_	_	_	_
105	reported	_	_	_	_	_	_	_	_
106	deaths	_	_	_	_	_	_	_	_
107	.	_	_	_	_	_	_	_	_
108	Reported	_	_	_	_	_	_	_	BeginSeg=Yes
109	deaths	_	_	_	_	_	_	_	_
110	were	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	unit	_	_	_	_	_	_	_	_
113	of	_	_	_	_	_	_	_	_
114	analysis	_	_	_	_	_	_	_	_
115	owing	_	_	_	_	_	_	_	BeginSeg=Yes
116	to	_	_	_	_	_	_	_	_
117	erratic	_	_	_	_	_	_	_	_
118	reporting	_	_	_	_	_	_	_	_
119	of	_	_	_	_	_	_	_	_
120	cases	_	_	_	_	_	_	_	_
121	from	_	_	_	_	_	_	_	_
122	variability	_	_	_	_	_	_	_	_
123	in	_	_	_	_	_	_	_	_
124	local	_	_	_	_	_	_	_	_
125	testing	_	_	_	_	_	_	_	_
126	strategies	_	_	_	_	_	_	_	_
127	.	_	_	_	_	_	_	_	_
128	We	_	_	_	_	_	_	_	BeginSeg=Yes
129	used	_	_	_	_	_	_	_	_
130	simulation	_	_	_	_	_	_	_	_
131	and	_	_	_	_	_	_	_	_
132	case	_	_	_	_	_	_	_	_
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136	chart	_	_	_	_	_	_	_	_
137	performance	_	_	_	_	_	_	_	_
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140	technical	_	_	_	_	_	_	_	_
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142	.	_	_	_	_	_	_	_	_
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148	other	_	_	_	_	_	_	_	_
149	critical	_	_	_	_	_	_	_	_
150	measures	_	_	_	_	_	_	_	_
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153	a	_	_	_	_	_	_	_	_
154	pandemic	_	_	_	_	_	_	_	_
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161	available	_	_	_	_	_	_	_	_
162	.	_	_	_	_	_	_	_	_
163	The	_	_	_	_	_	_	_	BeginSeg=Yes
164	hybrid	_	_	_	_	_	_	_	_
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171	growth	_	_	_	_	_	_	_	_
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175	signals	_	_	_	_	_	_	_	_
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177	the	_	_	_	_	_	_	_	_
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186	,	_	_	_	_	_	_	_	_
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189	signals	_	_	_	_	_	_	_	_
190	that	_	_	_	_	_	_	_	BeginSeg=Yes
191	an	_	_	_	_	_	_	_	_
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200	implications	_	_	_	_	_	_	_	_
201	.	_	_	_	_	_	_	_	_
202	This	_	_	_	_	_	_	_	BeginSeg=Yes
203	novel	_	_	_	_	_	_	_	_
204	chart	_	_	_	_	_	_	_	_
205	offers	_	_	_	_	_	_	_	_
206	a	_	_	_	_	_	_	_	_
207	practical	_	_	_	_	_	_	_	_
208	tool	_	_	_	_	_	_	_	_
209	,	_	_	_	_	_	_	_	_
210	accessible	_	_	_	_	_	_	_	BeginSeg=Yes
211	to	_	_	_	_	_	_	_	_
212	system	_	_	_	_	_	_	_	_
213	leaders	_	_	_	_	_	_	_	_
214	and	_	_	_	_	_	_	_	_
215	front	_	_	_	_	_	_	_	_
216	-	_	_	_	_	_	_	_	_
217	line	_	_	_	_	_	_	_	_
218	teams	_	_	_	_	_	_	_	_
219	,	_	_	_	_	_	_	_	_
220	to	_	_	_	_	_	_	_	BeginSeg=Yes
221	visualize	_	_	_	_	_	_	_	_
222	and	_	_	_	_	_	_	_	_
223	learn	_	_	_	_	_	_	_	_
224	from	_	_	_	_	_	_	_	_
225	daily	_	_	_	_	_	_	_	_
226	reported	_	_	_	_	_	_	_	_
227	deaths	_	_	_	_	_	_	_	_
228	during	_	_	_	_	_	_	_	_
229	an	_	_	_	_	_	_	_	_
230	epidemic	_	_	_	_	_	_	_	_
231	.	_	_	_	_	_	_	_	_
232	Without	_	_	_	_	_	_	_	BeginSeg=Yes
233	Shewhart	_	_	_	_	_	_	_	_
234	charts	_	_	_	_	_	_	_	_
235	and	_	_	_	_	_	_	_	_
236	,	_	_	_	_	_	_	_	_
237	more	_	_	_	_	_	_	_	_
238	broadly	_	_	_	_	_	_	_	_
239	,	_	_	_	_	_	_	_	_
240	a	_	_	_	_	_	_	_	_
241	theory	_	_	_	_	_	_	_	_
242	of	_	_	_	_	_	_	_	_
243	variation	_	_	_	_	_	_	_	_
244	in	_	_	_	_	_	_	_	_
245	our	_	_	_	_	_	_	_	_
246	epidemiological	_	_	_	_	_	_	_	_
247	arsenal	_	_	_	_	_	_	_	_
248	,	_	_	_	_	_	_	_	_
249	we	_	_	_	_	_	_	_	BeginSeg=Yes
250	lack	_	_	_	_	_	_	_	_
251	a	_	_	_	_	_	_	_	_
252	scientific	_	_	_	_	_	_	_	_
253	method	_	_	_	_	_	_	_	_
254	for	_	_	_	_	_	_	_	_
255	real	_	_	_	_	_	_	_	_
256	-	_	_	_	_	_	_	_	_
257	time	_	_	_	_	_	_	_	_
258	assessment	_	_	_	_	_	_	_	_
259	of	_	_	_	_	_	_	_	_
260	local	_	_	_	_	_	_	_	_
261	conditions	_	_	_	_	_	_	_	_
262	.	_	_	_	_	_	_	_	_
263	Shewhart	_	_	_	_	_	_	_	BeginSeg=Yes
264	charts	_	_	_	_	_	_	_	_
265	should	_	_	_	_	_	_	_	_
266	become	_	_	_	_	_	_	_	_
267	a	_	_	_	_	_	_	_	_
268	standard	_	_	_	_	_	_	_	_
269	method	_	_	_	_	_	_	_	_
270	for	_	_	_	_	_	_	_	BeginSeg=Yes
271	learning	_	_	_	_	_	_	_	_
272	from	_	_	_	_	_	_	_	_
273	data	_	_	_	_	_	_	_	_
274	in	_	_	_	_	_	_	_	_
275	the	_	_	_	_	_	_	_	_
276	context	_	_	_	_	_	_	_	_
277	of	_	_	_	_	_	_	_	_
278	a	_	_	_	_	_	_	_	_
279	pandemic	_	_	_	_	_	_	_	_
280	or	_	_	_	_	_	_	_	_
281	epidemic	_	_	_	_	_	_	_	_
282	.	_	_	_	_	_	_	_	_

# newdoc_id = abf6f66d8e18b652d10944bb21e19debca5dc5e8
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	Scutellaria	_	_	_	_	_	_	_	_
3	species	_	_	_	_	_	_	_	_
4	(	_	_	_	_	_	_	_	_
5	Lamiaceae	_	_	_	_	_	_	_	_
6	)	_	_	_	_	_	_	_	_
7	is	_	_	_	_	_	_	_	_
8	used	_	_	_	_	_	_	_	_
9	as	_	_	_	_	_	_	_	_
10	a	_	_	_	_	_	_	_	_
11	source	_	_	_	_	_	_	_	_
12	of	_	_	_	_	_	_	_	_
13	flavonoids	_	_	_	_	_	_	_	_
14	to	_	_	_	_	_	_	_	BeginSeg=Yes
15	treat	_	_	_	_	_	_	_	_
16	a	_	_	_	_	_	_	_	_
17	variety	_	_	_	_	_	_	_	_
18	of	_	_	_	_	_	_	_	_
19	diseases	_	_	_	_	_	_	_	_
20	in	_	_	_	_	_	_	_	_
21	traditional	_	_	_	_	_	_	_	_
22	medicine	_	_	_	_	_	_	_	_
23	.	_	_	_	_	_	_	_	_
24	In	_	_	_	_	_	_	_	BeginSeg=Yes
25	spite	_	_	_	_	_	_	_	_
26	of	_	_	_	_	_	_	_	_
27	many	_	_	_	_	_	_	_	_
28	reports	_	_	_	_	_	_	_	_
29	about	_	_	_	_	_	_	_	_
30	the	_	_	_	_	_	_	_	_
31	cytotoxic	_	_	_	_	_	_	_	_
32	and	_	_	_	_	_	_	_	_
33	antitumor	_	_	_	_	_	_	_	_
34	effects	_	_	_	_	_	_	_	_
35	of	_	_	_	_	_	_	_	_
36	some	_	_	_	_	_	_	_	_
37	species	_	_	_	_	_	_	_	_
38	of	_	_	_	_	_	_	_	_
39	this	_	_	_	_	_	_	_	_
40	genus	_	_	_	_	_	_	_	_
41	,	_	_	_	_	_	_	_	_
42	anticancer	_	_	_	_	_	_	_	BeginSeg=Yes
43	researches	_	_	_	_	_	_	_	_
44	on	_	_	_	_	_	_	_	_
45	one	_	_	_	_	_	_	_	_
46	of	_	_	_	_	_	_	_	_
47	the	_	_	_	_	_	_	_	_
48	Iranian	_	_	_	_	_	_	_	_
49	species	_	_	_	_	_	_	_	_
50	S.	_	_	_	_	_	_	_	_
51	litwinowii	_	_	_	_	_	_	_	_
52	have	_	_	_	_	_	_	_	_
53	not	_	_	_	_	_	_	_	_
54	yet	_	_	_	_	_	_	_	_
55	been	_	_	_	_	_	_	_	_
56	conducted	_	_	_	_	_	_	_	_
57	.	_	_	_	_	_	_	_	_
58	The	_	_	_	_	_	_	_	BeginSeg=Yes
59	cytotoxic	_	_	_	_	_	_	_	_
60	properties	_	_	_	_	_	_	_	_
61	of	_	_	_	_	_	_	_	_
62	total	_	_	_	_	_	_	_	_
63	methanol	_	_	_	_	_	_	_	_
64	extract	_	_	_	_	_	_	_	_
65	of	_	_	_	_	_	_	_	_
66	S.	_	_	_	_	_	_	_	_
67	litwinowii	_	_	_	_	_	_	_	_
68	and	_	_	_	_	_	_	_	_
69	its	_	_	_	_	_	_	_	_
70	fractions	_	_	_	_	_	_	_	_
71	were	_	_	_	_	_	_	_	_
72	investigated	_	_	_	_	_	_	_	_
73	on	_	_	_	_	_	_	_	_
74	different	_	_	_	_	_	_	_	_
75	cancer	_	_	_	_	_	_	_	_
76	cell	_	_	_	_	_	_	_	_
77	lines	_	_	_	_	_	_	_	_
78	including	_	_	_	_	_	_	_	BeginSeg=Yes
79	AGS	_	_	_	_	_	_	_	_
80	,	_	_	_	_	_	_	_	_
81	HeLa	_	_	_	_	_	_	_	_
82	,	_	_	_	_	_	_	_	_
83	MCF-7	_	_	_	_	_	_	_	_
84	,	_	_	_	_	_	_	_	_
85	PC12	_	_	_	_	_	_	_	_
86	and	_	_	_	_	_	_	_	_
87	NIH	_	_	_	_	_	_	_	_
88	3T3	_	_	_	_	_	_	_	_
89	.	_	_	_	_	_	_	_	_
90	Meanwhile	_	_	_	_	_	_	_	BeginSeg=Yes
91	,	_	_	_	_	_	_	_	_
92	the	_	_	_	_	_	_	_	_
93	role	_	_	_	_	_	_	_	_
94	of	_	_	_	_	_	_	_	_
95	apoptosis	_	_	_	_	_	_	_	_
96	in	_	_	_	_	_	_	_	_
97	this	_	_	_	_	_	_	_	_
98	toxicity	_	_	_	_	_	_	_	_
99	was	_	_	_	_	_	_	_	_
100	explored	_	_	_	_	_	_	_	_
101	.	_	_	_	_	_	_	_	_
102	The	_	_	_	_	_	_	_	BeginSeg=Yes
103	cells	_	_	_	_	_	_	_	_
104	were	_	_	_	_	_	_	_	_
105	cultured	_	_	_	_	_	_	_	_
106	in	_	_	_	_	_	_	_	_
107	DMEM	_	_	_	_	_	_	_	_
108	medium	_	_	_	_	_	_	_	_
109	and	_	_	_	_	_	_	_	BeginSeg=Yes
110	incubated	_	_	_	_	_	_	_	_
111	with	_	_	_	_	_	_	_	_
112	different	_	_	_	_	_	_	_	_
113	concentrations	_	_	_	_	_	_	_	_
114	of	_	_	_	_	_	_	_	_
115	herb	_	_	_	_	_	_	_	_
116	plant	_	_	_	_	_	_	_	_
117	extracts	_	_	_	_	_	_	_	_
118	.	_	_	_	_	_	_	_	_
119	Cell	_	_	_	_	_	_	_	BeginSeg=Yes
120	viability	_	_	_	_	_	_	_	_
121	was	_	_	_	_	_	_	_	_
122	quantitated	_	_	_	_	_	_	_	_
123	by	_	_	_	_	_	_	_	_
124	MTT	_	_	_	_	_	_	_	_
125	assay	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_
127	Apoptotic	_	_	_	_	_	_	_	BeginSeg=Yes
128	cells	_	_	_	_	_	_	_	_
129	were	_	_	_	_	_	_	_	_
130	determined	_	_	_	_	_	_	_	_
131	using	_	_	_	_	_	_	_	BeginSeg=Yes
132	propidium	_	_	_	_	_	_	_	_
133	iodide	_	_	_	_	_	_	_	_
134	staining	_	_	_	_	_	_	_	_
135	of	_	_	_	_	_	_	_	_
136	DNA	_	_	_	_	_	_	_	_
137	fragmentation	_	_	_	_	_	_	_	_
138	by	_	_	_	_	_	_	_	_
139	flow	_	_	_	_	_	_	_	_
140	cytometry	_	_	_	_	_	_	_	_
141	(	_	_	_	_	_	_	_	_
142	sub	_	_	_	_	_	_	_	_
143	-	_	_	_	_	_	_	_	_
144	G1	_	_	_	_	_	_	_	_
145	peak	_	_	_	_	_	_	_	_
146	)	_	_	_	_	_	_	_	_
147	.	_	_	_	_	_	_	_	_
148	Scutellaria	_	_	_	_	_	_	_	BeginSeg=Yes
149	litwinowii	_	_	_	_	_	_	_	_
150	inhibited	_	_	_	_	_	_	_	_
151	the	_	_	_	_	_	_	_	_
152	growth	_	_	_	_	_	_	_	_
153	of	_	_	_	_	_	_	_	_
154	malignant	_	_	_	_	_	_	_	_
155	cells	_	_	_	_	_	_	_	_
156	in	_	_	_	_	_	_	_	_
157	a	_	_	_	_	_	_	_	_
158	dose	_	_	_	_	_	_	_	_
159	-	_	_	_	_	_	_	_	_
160	dependent	_	_	_	_	_	_	_	_
161	manner	_	_	_	_	_	_	_	_
162	.	_	_	_	_	_	_	_	_
163	Among	_	_	_	_	_	_	_	BeginSeg=Yes
164	solvent	_	_	_	_	_	_	_	_
165	fractions	_	_	_	_	_	_	_	_
166	of	_	_	_	_	_	_	_	_
167	S.	_	_	_	_	_	_	_	_
168	litwinowii	_	_	_	_	_	_	_	_
169	,	_	_	_	_	_	_	_	_
170	the	_	_	_	_	_	_	_	_
171	methylene	_	_	_	_	_	_	_	_
172	chloride	_	_	_	_	_	_	_	_
173	fraction	_	_	_	_	_	_	_	_
174	was	_	_	_	_	_	_	_	_
175	found	_	_	_	_	_	_	_	_
176	to	_	_	_	_	_	_	_	_
177	be	_	_	_	_	_	_	_	_
178	more	_	_	_	_	_	_	_	_
179	toxic	_	_	_	_	_	_	_	_
180	compared	_	_	_	_	_	_	_	BeginSeg=Yes
181	to	_	_	_	_	_	_	_	_
182	other	_	_	_	_	_	_	_	_
183	fractions	_	_	_	_	_	_	_	_
184	.	_	_	_	_	_	_	_	_
185	The	_	_	_	_	_	_	_	BeginSeg=Yes
186	IC	_	_	_	_	_	_	_	_
187	50	_	_	_	_	_	_	_	_
188	values	_	_	_	_	_	_	_	_
189	of	_	_	_	_	_	_	_	_
190	this	_	_	_	_	_	_	_	_
191	fraction	_	_	_	_	_	_	_	_
192	against	_	_	_	_	_	_	_	_
193	AGS	_	_	_	_	_	_	_	_
194	,	_	_	_	_	_	_	_	_
195	HeLa	_	_	_	_	_	_	_	_
196	,	_	_	_	_	_	_	_	_
197	MCF-7	_	_	_	_	_	_	_	_
198	and	_	_	_	_	_	_	_	_
199	PC12	_	_	_	_	_	_	_	_
200	cell	_	_	_	_	_	_	_	_
201	lines	_	_	_	_	_	_	_	_
202	after	_	_	_	_	_	_	_	_
203	24	_	_	_	_	_	_	_	_
204	h	_	_	_	_	_	_	_	_
205	were	_	_	_	_	_	_	_	_
206	determined	_	_	_	_	_	_	_	_
207	,	_	_	_	_	_	_	_	_
208	121.2	_	_	_	_	_	_	_	_
209	±	_	_	_	_	_	_	_	_
210	3.1	_	_	_	_	_	_	_	_
211	,	_	_	_	_	_	_	_	_
212	40.9	_	_	_	_	_	_	_	_
213	±	_	_	_	_	_	_	_	_
214	2.5	_	_	_	_	_	_	_	_
215	,	_	_	_	_	_	_	_	_
216	115.9	_	_	_	_	_	_	_	_
217	±	_	_	_	_	_	_	_	_
218	3.5	_	_	_	_	_	_	_	_
219	and	_	_	_	_	_	_	_	_
220	64.5	_	_	_	_	_	_	_	_
221	±	_	_	_	_	_	_	_	_
222	3.4	_	_	_	_	_	_	_	_
223	μg	_	_	_	_	_	_	_	_
224	/	_	_	_	_	_	_	_	_
225	ml	_	_	_	_	_	_	_	_
226	,	_	_	_	_	_	_	_	_
227	respectively	_	_	_	_	_	_	_	_
228	.	_	_	_	_	_	_	_	_
229	Scutellaria	_	_	_	_	_	_	_	BeginSeg=Yes
230	litwinowii	_	_	_	_	_	_	_	_
231	induced	_	_	_	_	_	_	_	_
232	a	_	_	_	_	_	_	_	_
233	sub	_	_	_	_	_	_	_	_
234	-	_	_	_	_	_	_	_	_
235	G1	_	_	_	_	_	_	_	_
236	peak	_	_	_	_	_	_	_	_
237	in	_	_	_	_	_	_	_	_
238	the	_	_	_	_	_	_	_	_
239	flow	_	_	_	_	_	_	_	_
240	cytometry	_	_	_	_	_	_	_	_
241	histogram	_	_	_	_	_	_	_	_
242	of	_	_	_	_	_	_	_	_
243	treated	_	_	_	_	_	_	_	_
244	cells	_	_	_	_	_	_	_	_
245	compared	_	_	_	_	_	_	_	BeginSeg=Yes
246	to	_	_	_	_	_	_	_	_
247	control	_	_	_	_	_	_	_	_
248	cells	_	_	_	_	_	_	_	_
249	indicating	_	_	_	_	_	_	_	BeginSeg=Yes
250	that	_	_	_	_	_	_	_	BeginSeg=Yes
251	apoptotic	_	_	_	_	_	_	_	_
252	cell	_	_	_	_	_	_	_	_
253	death	_	_	_	_	_	_	_	_
254	is	_	_	_	_	_	_	_	_
255	involved	_	_	_	_	_	_	_	_
256	in	_	_	_	_	_	_	_	_
257	S.	_	_	_	_	_	_	_	_
258	litwinowii	_	_	_	_	_	_	_	_
259	toxicity	_	_	_	_	_	_	_	_
260	.	_	_	_	_	_	_	_	_
261	Scutellaria	_	_	_	_	_	_	_	BeginSeg=Yes
262	litwinowii	_	_	_	_	_	_	_	_
263	exerts	_	_	_	_	_	_	_	_
264	cytotoxic	_	_	_	_	_	_	_	_
265	and	_	_	_	_	_	_	_	_
266	proapototic	_	_	_	_	_	_	_	_
267	effects	_	_	_	_	_	_	_	_
268	in	_	_	_	_	_	_	_	_
269	a	_	_	_	_	_	_	_	_
270	variety	_	_	_	_	_	_	_	_
271	of	_	_	_	_	_	_	_	_
272	malignant	_	_	_	_	_	_	_	_
273	cell	_	_	_	_	_	_	_	_
274	lines	_	_	_	_	_	_	_	_
275	and	_	_	_	_	_	_	_	BeginSeg=Yes
276	could	_	_	_	_	_	_	_	_
277	be	_	_	_	_	_	_	_	_
278	considered	_	_	_	_	_	_	_	_
279	as	_	_	_	_	_	_	_	_
280	a	_	_	_	_	_	_	_	_
281	potential	_	_	_	_	_	_	_	_
282	chemotherapeutic	_	_	_	_	_	_	_	_
283	agent	_	_	_	_	_	_	_	_
284	in	_	_	_	_	_	_	_	_
285	cancer	_	_	_	_	_	_	_	_
286	treatment	_	_	_	_	_	_	_	_
287	.	_	_	_	_	_	_	_	_

# newdoc_id = ad71472308fc72f2b3fe0044ac4bc2f08c4481b6
1	Feline	_	_	_	_	_	_	_	BeginSeg=Yes
2	infectious	_	_	_	_	_	_	_	_
3	peritonitis	_	_	_	_	_	_	_	_
4	is	_	_	_	_	_	_	_	_
5	a	_	_	_	_	_	_	_	_
6	devastating	_	_	_	_	_	_	_	_
7	,	_	_	_	_	_	_	_	_
8	fatal	_	_	_	_	_	_	_	_
9	disease	_	_	_	_	_	_	_	_
10	of	_	_	_	_	_	_	_	_
11	domestic	_	_	_	_	_	_	_	_
12	cats	_	_	_	_	_	_	_	_
13	caused	_	_	_	_	_	_	_	BeginSeg=Yes
14	by	_	_	_	_	_	_	_	_
15	a	_	_	_	_	_	_	_	_
16	pathogenic	_	_	_	_	_	_	_	_
17	mutant	_	_	_	_	_	_	_	_
18	virus	_	_	_	_	_	_	_	_
19	derived	_	_	_	_	_	_	_	BeginSeg=Yes
20	from	_	_	_	_	_	_	_	_
21	the	_	_	_	_	_	_	_	_
22	ubiquitous	_	_	_	_	_	_	_	_
23	feline	_	_	_	_	_	_	_	_
24	enteric	_	_	_	_	_	_	_	_
25	coronavirus	_	_	_	_	_	_	_	_
26	(	_	_	_	_	_	_	_	_
27	FECV	_	_	_	_	_	_	_	_
28	)	_	_	_	_	_	_	_	_
29	.	_	_	_	_	_	_	_	_
30	Infection	_	_	_	_	_	_	_	BeginSeg=Yes
31	by	_	_	_	_	_	_	_	_
32	FECV	_	_	_	_	_	_	_	_
33	is	_	_	_	_	_	_	_	_
34	generally	_	_	_	_	_	_	_	_
35	subclinical	_	_	_	_	_	_	_	_
36	,	_	_	_	_	_	_	_	_
37	and	_	_	_	_	_	_	_	BeginSeg=Yes
38	little	_	_	_	_	_	_	_	_
39	is	_	_	_	_	_	_	_	_
40	known	_	_	_	_	_	_	_	_
41	about	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
43	mucosal	_	_	_	_	_	_	_	_
44	immune	_	_	_	_	_	_	_	_
45	response	_	_	_	_	_	_	_	_
46	that	_	_	_	_	_	_	_	BeginSeg=Yes
47	controls	_	_	_	_	_	_	_	_
48	and	_	_	_	_	_	_	_	_
49	eliminates	_	_	_	_	_	_	_	_
50	the	_	_	_	_	_	_	_	_
51	virus	_	_	_	_	_	_	_	_
52	.	_	_	_	_	_	_	_	_
53	We	_	_	_	_	_	_	_	BeginSeg=Yes
54	investigated	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	mucosal	_	_	_	_	_	_	_	_
57	immune	_	_	_	_	_	_	_	_
58	response	_	_	_	_	_	_	_	_
59	against	_	_	_	_	_	_	_	_
60	FECV	_	_	_	_	_	_	_	_
61	in	_	_	_	_	_	_	_	_
62	an	_	_	_	_	_	_	_	_
63	endemically	_	_	_	_	_	_	_	_
64	infected	_	_	_	_	_	_	_	_
65	breeding	_	_	_	_	_	_	_	_
66	colony	_	_	_	_	_	_	_	_
67	over	_	_	_	_	_	_	_	_
68	a	_	_	_	_	_	_	_	_
69	seven	_	_	_	_	_	_	_	_
70	-	_	_	_	_	_	_	_	_
71	month	_	_	_	_	_	_	_	_
72	period	_	_	_	_	_	_	_	_
73	.	_	_	_	_	_	_	_	_
74	Thirty	_	_	_	_	_	_	_	BeginSeg=Yes
75	-	_	_	_	_	_	_	_	_
76	three	_	_	_	_	_	_	_	_
77	cats	_	_	_	_	_	_	_	_
78	were	_	_	_	_	_	_	_	_
79	grouped	_	_	_	_	_	_	_	_
80	according	_	_	_	_	_	_	_	_
81	to	_	_	_	_	_	_	_	_
82	FECV	_	_	_	_	_	_	_	_
83	seropositivity	_	_	_	_	_	_	_	_
84	and	_	_	_	_	_	_	_	_
85	fecal	_	_	_	_	_	_	_	_
86	virus	_	_	_	_	_	_	_	_
87	shedding	_	_	_	_	_	_	_	_
88	into	_	_	_	_	_	_	_	_
89	naïve	_	_	_	_	_	_	_	_
90	/	_	_	_	_	_	_	_	_
91	immunologically	_	_	_	_	_	_	_	_
92	quiescent	_	_	_	_	_	_	_	_
93	,	_	_	_	_	_	_	_	_
94	convalescent	_	_	_	_	_	_	_	_
95	and	_	_	_	_	_	_	_	_
96	actively	_	_	_	_	_	_	_	_
97	infected	_	_	_	_	_	_	_	_
98	groups	_	_	_	_	_	_	_	_
99	.	_	_	_	_	_	_	_	_
100	Blood	_	_	_	_	_	_	_	BeginSeg=Yes
101	,	_	_	_	_	_	_	_	_
102	fecal	_	_	_	_	_	_	_	_
103	samples	_	_	_	_	_	_	_	_
104	and	_	_	_	_	_	_	_	_
105	colon	_	_	_	_	_	_	_	_
106	biopsies	_	_	_	_	_	_	_	_
107	were	_	_	_	_	_	_	_	_
108	collected	_	_	_	_	_	_	_	_
109	to	_	_	_	_	_	_	_	BeginSeg=Yes
110	assess	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	mucosal	_	_	_	_	_	_	_	_
113	and	_	_	_	_	_	_	_	_
114	systemic	_	_	_	_	_	_	_	_
115	immunologic	_	_	_	_	_	_	_	_
116	and	_	_	_	_	_	_	_	_
117	virologic	_	_	_	_	_	_	_	_
118	profile	_	_	_	_	_	_	_	_
119	.	_	_	_	_	_	_	_	_
120	Results	_	_	_	_	_	_	_	BeginSeg=Yes
121	showed	_	_	_	_	_	_	_	_
122	that	_	_	_	_	_	_	_	BeginSeg=Yes
123	cats	_	_	_	_	_	_	_	_
124	with	_	_	_	_	_	_	_	_
125	active	_	_	_	_	_	_	_	_
126	FECV	_	_	_	_	_	_	_	_
127	infections	_	_	_	_	_	_	_	_
128	have	_	_	_	_	_	_	_	_
129	strong	_	_	_	_	_	_	_	_
130	systemic	_	_	_	_	_	_	_	_
131	IgG	_	_	_	_	_	_	_	_
132	and	_	_	_	_	_	_	_	_
133	mucosal	_	_	_	_	_	_	_	_
134	IgA	_	_	_	_	_	_	_	_
135	responses	_	_	_	_	_	_	_	_
136	that	_	_	_	_	_	_	_	BeginSeg=Yes
137	wane	_	_	_	_	_	_	_	_
138	after	_	_	_	_	_	_	_	_
139	virus	_	_	_	_	_	_	_	_
140	clearance	_	_	_	_	_	_	_	_
141	.	_	_	_	_	_	_	_	_
142	Significant	_	_	_	_	_	_	_	BeginSeg=Yes
143	FECV	_	_	_	_	_	_	_	_
144	-	_	_	_	_	_	_	_	_
145	specific	_	_	_	_	_	_	_	_
146	mucosal	_	_	_	_	_	_	_	_
147	T	_	_	_	_	_	_	_	_
148	cell	_	_	_	_	_	_	_	_
149	IFNγ	_	_	_	_	_	_	_	_
150	responses	_	_	_	_	_	_	_	_
151	were	_	_	_	_	_	_	_	_
152	not	_	_	_	_	_	_	_	_
153	detected	_	_	_	_	_	_	_	_
154	in	_	_	_	_	_	_	_	_
155	any	_	_	_	_	_	_	_	_
156	of	_	_	_	_	_	_	_	_
157	the	_	_	_	_	_	_	_	_
158	three	_	_	_	_	_	_	_	_
159	groups	_	_	_	_	_	_	_	_
160	.	_	_	_	_	_	_	_	_
161	A	_	_	_	_	_	_	_	BeginSeg=Yes
162	shift	_	_	_	_	_	_	_	_
163	toward	_	_	_	_	_	_	_	_
164	an	_	_	_	_	_	_	_	_
165	inflammatory	_	_	_	_	_	_	_	_
166	state	_	_	_	_	_	_	_	_
167	in	_	_	_	_	_	_	_	_
168	the	_	_	_	_	_	_	_	_
169	mucosa	_	_	_	_	_	_	_	_
170	was	_	_	_	_	_	_	_	_
171	suggested	_	_	_	_	_	_	_	_
172	by	_	_	_	_	_	_	_	_
173	increased	_	_	_	_	_	_	_	_
174	IL17	_	_	_	_	_	_	_	_
175	:	_	_	_	_	_	_	_	_
176	FoxP3	_	_	_	_	_	_	_	_
177	expression	_	_	_	_	_	_	_	_
178	.	_	_	_	_	_	_	_	_
179	However	_	_	_	_	_	_	_	BeginSeg=Yes
180	,	_	_	_	_	_	_	_	_
181	no	_	_	_	_	_	_	_	_
182	histologic	_	_	_	_	_	_	_	_
183	abnormalities	_	_	_	_	_	_	_	_
184	were	_	_	_	_	_	_	_	_
185	observed	_	_	_	_	_	_	_	_
186	,	_	_	_	_	_	_	_	_
187	and	_	_	_	_	_	_	_	BeginSeg=Yes
188	no	_	_	_	_	_	_	_	_
189	shifts	_	_	_	_	_	_	_	_
190	in	_	_	_	_	_	_	_	_
191	lymphocyte	_	_	_	_	_	_	_	_
192	subpopulation	_	_	_	_	_	_	_	_
193	phenotype	_	_	_	_	_	_	_	_
194	or	_	_	_	_	_	_	_	_
195	proliferation	_	_	_	_	_	_	_	_
196	were	_	_	_	_	_	_	_	_
197	noted	_	_	_	_	_	_	_	_
198	.	_	_	_	_	_	_	_	_
199	Together	_	_	_	_	_	_	_	BeginSeg=Yes
200	,	_	_	_	_	_	_	_	_
201	the	_	_	_	_	_	_	_	_
202	results	_	_	_	_	_	_	_	_
203	suggest	_	_	_	_	_	_	_	_
204	that	_	_	_	_	_	_	_	BeginSeg=Yes
205	control	_	_	_	_	_	_	_	_
206	of	_	_	_	_	_	_	_	_
207	FECV	_	_	_	_	_	_	_	_
208	is	_	_	_	_	_	_	_	_
209	mediated	_	_	_	_	_	_	_	_
210	by	_	_	_	_	_	_	_	_
211	humoral	_	_	_	_	_	_	_	_
212	mucosal	_	_	_	_	_	_	_	_
213	and	_	_	_	_	_	_	_	_
214	systemic	_	_	_	_	_	_	_	_
215	responses	_	_	_	_	_	_	_	_
216	and	_	_	_	_	_	_	_	BeginSeg=Yes
217	that	_	_	_	_	_	_	_	_
218	perturbations	_	_	_	_	_	_	_	_
219	in	_	_	_	_	_	_	_	_
220	the	_	_	_	_	_	_	_	_
221	primary	_	_	_	_	_	_	_	_
222	reservoir	_	_	_	_	_	_	_	_
223	organ	_	_	_	_	_	_	_	_
224	(	_	_	_	_	_	_	_	_
225	colon	_	_	_	_	_	_	_	_
226	)	_	_	_	_	_	_	_	_
227	are	_	_	_	_	_	_	_	_
228	minimal	_	_	_	_	_	_	_	_
229	.	_	_	_	_	_	_	_	_

# newdoc_id = ae382b26740aa78bdfb76f6e470dcf71a3263db9
1	Previous	_	_	_	_	_	_	_	BeginSeg=Yes
2	analysis	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	porcine	_	_	_	_	_	_	_	_
5	respiratory	_	_	_	_	_	_	_	_
6	coronavirus	_	_	_	_	_	_	_	_
7	(	_	_	_	_	_	_	_	_
8	PRCV	_	_	_	_	_	_	_	_
9	)	_	_	_	_	_	_	_	_
10	mRNA	_	_	_	_	_	_	_	_
11	species	_	_	_	_	_	_	_	_
12	showed	_	_	_	_	_	_	_	_
13	that	_	_	_	_	_	_	_	BeginSeg=Yes
14	mRNAs	_	_	_	_	_	_	_	_
15	2	_	_	_	_	_	_	_	_
16	and	_	_	_	_	_	_	_	_
17	3	_	_	_	_	_	_	_	_
18	were	_	_	_	_	_	_	_	_
19	smaller	_	_	_	_	_	_	_	_
20	than	_	_	_	_	_	_	_	_
21	the	_	_	_	_	_	_	_	_
22	corresponding	_	_	_	_	_	_	_	_
23	transmissible	_	_	_	_	_	_	_	_
24	gastroenteritis	_	_	_	_	_	_	_	_
25	virus	_	_	_	_	_	_	_	_
26	(	_	_	_	_	_	_	_	_
27	TGEV	_	_	_	_	_	_	_	_
28	)	_	_	_	_	_	_	_	_
29	mRNA	_	_	_	_	_	_	_	_
30	species	_	_	_	_	_	_	_	_
31	(	_	_	_	_	_	_	_	_
32	Page	_	_	_	_	_	_	_	_
33	et	_	_	_	_	_	_	_	_
34	al	_	_	_	_	_	_	_	_
35	.	_	_	_	_	_	_	_	_
36	(	_	_	_	_	_	_	_	_
37	1991	_	_	_	_	_	_	_	_
38	)	_	_	_	_	_	_	_	_
39	J.	_	_	_	_	_	_	_	_
40	Gen.	_	_	_	_	_	_	_	_
41	Virol	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
43	72	_	_	_	_	_	_	_	_
44	,	_	_	_	_	_	_	_	_
45	579	_	_	_	_	_	_	_	_
46	-	_	_	_	_	_	_	_	_
47	587	_	_	_	_	_	_	_	_
48	)	_	_	_	_	_	_	_	_
49	.	_	_	_	_	_	_	_	_
50	Sequence	_	_	_	_	_	_	_	BeginSeg=Yes
51	analysis	_	_	_	_	_	_	_	_
52	showed	_	_	_	_	_	_	_	_
53	that	_	_	_	_	_	_	_	BeginSeg=Yes
54	mRNA	_	_	_	_	_	_	_	_
55	3	_	_	_	_	_	_	_	_
56	was	_	_	_	_	_	_	_	_
57	smaller	_	_	_	_	_	_	_	_
58	due	_	_	_	_	_	_	_	BeginSeg=Yes
59	to	_	_	_	_	_	_	_	_
60	the	_	_	_	_	_	_	_	_
61	presence	_	_	_	_	_	_	_	_
62	of	_	_	_	_	_	_	_	_
63	a	_	_	_	_	_	_	_	_
64	new	_	_	_	_	_	_	_	_
65	putative	_	_	_	_	_	_	_	_
66	RNA	_	_	_	_	_	_	_	_
67	-	_	_	_	_	_	_	_	_
68	leader	_	_	_	_	_	_	_	_
69	binding	_	_	_	_	_	_	_	_
70	site	_	_	_	_	_	_	_	_
71	upstream	_	_	_	_	_	_	_	_
72	of	_	_	_	_	_	_	_	_
73	the	_	_	_	_	_	_	_	_
74	PRCV	_	_	_	_	_	_	_	_
75	ORF-3	_	_	_	_	_	_	_	_
76	gene	_	_	_	_	_	_	_	_
77	.	_	_	_	_	_	_	_	_
78	However	_	_	_	_	_	_	_	BeginSeg=Yes
79	,	_	_	_	_	_	_	_	_
80	this	_	_	_	_	_	_	_	_
81	observation	_	_	_	_	_	_	_	_
82	did	_	_	_	_	_	_	_	_
83	not	_	_	_	_	_	_	_	_
84	explain	_	_	_	_	_	_	_	_
85	the	_	_	_	_	_	_	_	_
86	deletion	_	_	_	_	_	_	_	_
87	observed	_	_	_	_	_	_	_	BeginSeg=Yes
88	in	_	_	_	_	_	_	_	_
89	PRCV	_	_	_	_	_	_	_	_
90	mRNA	_	_	_	_	_	_	_	_
91	2	_	_	_	_	_	_	_	_
92	.	_	_	_	_	_	_	_	_
93	Polymerase	_	_	_	_	_	_	_	BeginSeg=Yes
94	chain	_	_	_	_	_	_	_	_
95	reaction	_	_	_	_	_	_	_	_
96	(	_	_	_	_	_	_	_	_
97	PCR	_	_	_	_	_	_	_	_
98	)	_	_	_	_	_	_	_	_
99	was	_	_	_	_	_	_	_	_
100	used	_	_	_	_	_	_	_	_
101	to	_	_	_	_	_	_	_	BeginSeg=Yes
102	generate	_	_	_	_	_	_	_	_
103	cDNA	_	_	_	_	_	_	_	_
104	from	_	_	_	_	_	_	_	_
105	the	_	_	_	_	_	_	_	_
106	3	_	_	_	_	_	_	_	_
107	'	_	_	_	_	_	_	_	_
108	coding	_	_	_	_	_	_	_	_
109	region	_	_	_	_	_	_	_	_
110	of	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	putative	_	_	_	_	_	_	_	_
113	polymerase	_	_	_	_	_	_	_	_
114	gene	_	_	_	_	_	_	_	_
115	to	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	_
117	poly	_	_	_	_	_	_	_	_
118	(	_	_	_	_	_	_	_	_
119	A	_	_	_	_	_	_	_	_
120	)	_	_	_	_	_	_	_	_
121	tail	_	_	_	_	_	_	_	_
122	of	_	_	_	_	_	_	_	_
123	PRCV	_	_	_	_	_	_	_	_
124	for	_	_	_	_	_	_	_	_
125	comparison	_	_	_	_	_	_	_	_
126	to	_	_	_	_	_	_	_	_
127	the	_	_	_	_	_	_	_	_
128	equivalent	_	_	_	_	_	_	_	_
129	region	_	_	_	_	_	_	_	_
130	from	_	_	_	_	_	_	_	_
131	TGEV	_	_	_	_	_	_	_	_
132	.	_	_	_	_	_	_	_	_
133	The	_	_	_	_	_	_	_	BeginSeg=Yes
134	PRCV	_	_	_	_	_	_	_	_
135	S	_	_	_	_	_	_	_	_
136	protein	_	_	_	_	_	_	_	_
137	was	_	_	_	_	_	_	_	_
138	found	_	_	_	_	_	_	_	_
139	to	_	_	_	_	_	_	_	_
140	consist	_	_	_	_	_	_	_	_
141	of	_	_	_	_	_	_	_	_
142	1225	_	_	_	_	_	_	_	_
143	amino	_	_	_	_	_	_	_	_
144	acids	_	_	_	_	_	_	_	_
145	,	_	_	_	_	_	_	_	_
146	which	_	_	_	_	_	_	_	BeginSeg=Yes
147	had	_	_	_	_	_	_	_	_
148	98	_	_	_	_	_	_	_	_
149	%	_	_	_	_	_	_	_	_
150	similarity	_	_	_	_	_	_	_	_
151	to	_	_	_	_	_	_	_	_
152	the	_	_	_	_	_	_	_	_
153	TGEV	_	_	_	_	_	_	_	_
154	S	_	_	_	_	_	_	_	_
155	protein	_	_	_	_	_	_	_	_
156	.	_	_	_	_	_	_	_	_
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158	,	_	_	_	_	_	_	_	_
159	the	_	_	_	_	_	_	_	_
160	PRCV	_	_	_	_	_	_	_	_
161	S	_	_	_	_	_	_	_	_
162	gene	_	_	_	_	_	_	_	_
163	contained	_	_	_	_	_	_	_	_
164	a	_	_	_	_	_	_	_	_
165	672	_	_	_	_	_	_	_	_
166	nucleotide	_	_	_	_	_	_	_	_
167	deletion	_	_	_	_	_	_	_	_
168	,	_	_	_	_	_	_	_	_
169	corresponding	_	_	_	_	_	_	_	BeginSeg=Yes
170	to	_	_	_	_	_	_	_	_
171	224	_	_	_	_	_	_	_	_
172	amino	_	_	_	_	_	_	_	_
173	acids	_	_	_	_	_	_	_	_
174	(	_	_	_	_	_	_	_	BeginSeg=Yes
175	residues	_	_	_	_	_	_	_	_
176	21	_	_	_	_	_	_	_	_
177	to	_	_	_	_	_	_	_	_
178	245	_	_	_	_	_	_	_	_
179	in	_	_	_	_	_	_	_	_
180	TGEV	_	_	_	_	_	_	_	_
181	S	_	_	_	_	_	_	_	_
182	protein	_	_	_	_	_	_	_	_
183	)	_	_	_	_	_	_	_	_
184	,	_	_	_	_	_	_	_	_
185	59	_	_	_	_	_	_	_	BeginSeg=Yes
186	nucleotides	_	_	_	_	_	_	_	_
187	downstream	_	_	_	_	_	_	_	_
188	of	_	_	_	_	_	_	_	_
189	the	_	_	_	_	_	_	_	_
190	S	_	_	_	_	_	_	_	_
191	gene	_	_	_	_	_	_	_	_
192	initiation	_	_	_	_	_	_	_	_
193	codon	_	_	_	_	_	_	_	_
194	.	_	_	_	_	_	_	_	_
195	The	_	_	_	_	_	_	_	BeginSeg=Yes
196	PRCV	_	_	_	_	_	_	_	_
197	genome	_	_	_	_	_	_	_	_
198	from	_	_	_	_	_	_	_	_
199	the	_	_	_	_	_	_	_	_
200	ORF-3	_	_	_	_	_	_	_	_
201	gene	_	_	_	_	_	_	_	_
202	to	_	_	_	_	_	_	_	_
203	the	_	_	_	_	_	_	_	_
204	poly	_	_	_	_	_	_	_	_
205	(	_	_	_	_	_	_	_	_
206	A	_	_	_	_	_	_	_	_
207	)	_	_	_	_	_	_	_	_
208	tail	_	_	_	_	_	_	_	_
209	was	_	_	_	_	_	_	_	_
210	sequenced	_	_	_	_	_	_	_	_
211	for	_	_	_	_	_	_	_	_
212	comparison	_	_	_	_	_	_	_	_
213	to	_	_	_	_	_	_	_	_
214	TGEV	_	_	_	_	_	_	_	_
215	in	_	_	_	_	_	_	_	BeginSeg=Yes
216	order	_	_	_	_	_	_	_	_
217	to	_	_	_	_	_	_	_	_
218	identify	_	_	_	_	_	_	_	_
219	other	_	_	_	_	_	_	_	_
220	potential	_	_	_	_	_	_	_	_
221	differences	_	_	_	_	_	_	_	_
222	between	_	_	_	_	_	_	_	_
223	the	_	_	_	_	_	_	_	_
224	two	_	_	_	_	_	_	_	_
225	viruses	_	_	_	_	_	_	_	_
226	.	_	_	_	_	_	_	_	_
227	Four	_	_	_	_	_	_	_	BeginSeg=Yes
228	ORFs	_	_	_	_	_	_	_	_
229	were	_	_	_	_	_	_	_	_
230	identified	_	_	_	_	_	_	_	_
231	that	_	_	_	_	_	_	_	BeginSeg=Yes
232	showed	_	_	_	_	_	_	_	_
233	98	_	_	_	_	_	_	_	_
234	%	_	_	_	_	_	_	_	_
235	similarity	_	_	_	_	_	_	_	_
236	to	_	_	_	_	_	_	_	_
237	the	_	_	_	_	_	_	_	_
238	TGEV	_	_	_	_	_	_	_	_
239	ORF-4	_	_	_	_	_	_	_	_
240	,	_	_	_	_	_	_	_	_
241	M	_	_	_	_	_	_	_	_
242	,	_	_	_	_	_	_	_	_
243	N	_	_	_	_	_	_	_	_
244	and	_	_	_	_	_	_	_	_
245	ORF-7	_	_	_	_	_	_	_	_
246	genes	_	_	_	_	_	_	_	_
247	.	_	_	_	_	_	_	_	_
248	No	_	_	_	_	_	_	_	BeginSeg=Yes
249	other	_	_	_	_	_	_	_	_
250	deletions	_	_	_	_	_	_	_	_
251	or	_	_	_	_	_	_	_	_
252	any	_	_	_	_	_	_	_	_
253	PRCV	_	_	_	_	_	_	_	_
254	specific	_	_	_	_	_	_	_	_
255	sequences	_	_	_	_	_	_	_	_
256	were	_	_	_	_	_	_	_	_
257	identified	_	_	_	_	_	_	_	_
258	.	_	_	_	_	_	_	_	_

# newdoc_id = afac086b9492b66969c0f1af5c95e804d111cb3c
1	It	_	_	_	_	_	_	_	BeginSeg=Yes
2	is	_	_	_	_	_	_	_	_
3	increasingly	_	_	_	_	_	_	_	_
4	evident	_	_	_	_	_	_	_	_
5	that	_	_	_	_	_	_	_	_
6	China	_	_	_	_	_	_	_	_
7	has	_	_	_	_	_	_	_	_
8	attached	_	_	_	_	_	_	_	_
9	more	_	_	_	_	_	_	_	_
10	attention	_	_	_	_	_	_	_	_
11	to	_	_	_	_	_	_	_	_
12	discursive	_	_	_	_	_	_	_	_
13	power	_	_	_	_	_	_	_	_
14	in	_	_	_	_	_	_	_	_
15	foreign	_	_	_	_	_	_	_	_
16	policy	_	_	_	_	_	_	_	_
17	since	_	_	_	_	_	_	_	_
18	the	_	_	_	_	_	_	_	_
19	early	_	_	_	_	_	_	_	_
20	21st	_	_	_	_	_	_	_	_
21	century	_	_	_	_	_	_	_	_
22	.	_	_	_	_	_	_	_	_
23	Both	_	_	_	_	_	_	_	BeginSeg=Yes
24	top	_	_	_	_	_	_	_	_
25	leaders	_	_	_	_	_	_	_	_
26	and	_	_	_	_	_	_	_	_
27	government	_	_	_	_	_	_	_	_
28	agencies	_	_	_	_	_	_	_	_
29	have	_	_	_	_	_	_	_	_
30	been	_	_	_	_	_	_	_	_
31	active	_	_	_	_	_	_	_	_
32	in	_	_	_	_	_	_	_	BeginSeg=Yes
33	advocating	_	_	_	_	_	_	_	_
34	for	_	_	_	_	_	_	_	_
35	a	_	_	_	_	_	_	_	_
36	new	_	_	_	_	_	_	_	_
37	discourse	_	_	_	_	_	_	_	_
38	on	_	_	_	_	_	_	_	_
39	various	_	_	_	_	_	_	_	_
40	international	_	_	_	_	_	_	_	_
41	occasions	_	_	_	_	_	_	_	_
42	.	_	_	_	_	_	_	_	_
43	Previously	_	_	_	_	_	_	_	BeginSeg=Yes
44	,	_	_	_	_	_	_	_	_
45	China	_	_	_	_	_	_	_	_
46	has	_	_	_	_	_	_	_	_
47	been	_	_	_	_	_	_	_	_
48	reluctant	_	_	_	_	_	_	_	_
49	to	_	_	_	_	_	_	_	_
50	join	_	_	_	_	_	_	_	_
51	the	_	_	_	_	_	_	_	_
52	debate	_	_	_	_	_	_	_	_
53	in	_	_	_	_	_	_	_	_
54	international	_	_	_	_	_	_	_	_
55	affairs	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	and	_	_	_	_	_	_	_	BeginSeg=Yes
58	been	_	_	_	_	_	_	_	_
59	instead	_	_	_	_	_	_	_	_
60	preoccupied	_	_	_	_	_	_	_	_
61	with	_	_	_	_	_	_	_	_
62	domestic	_	_	_	_	_	_	_	_
63	affairs	_	_	_	_	_	_	_	_
64	since	_	_	_	_	_	_	_	_
65	the	_	_	_	_	_	_	_	_
66	late	_	_	_	_	_	_	_	_
67	1970s	_	_	_	_	_	_	_	_
68	.	_	_	_	_	_	_	_	_
69	The	_	_	_	_	_	_	_	BeginSeg=Yes
70	situation	_	_	_	_	_	_	_	_
71	has	_	_	_	_	_	_	_	_
72	changed	_	_	_	_	_	_	_	_
73	since	_	_	_	_	_	_	_	_
74	2009	_	_	_	_	_	_	_	_
75	because	_	_	_	_	_	_	_	BeginSeg=Yes
76	of	_	_	_	_	_	_	_	_
77-78	China's	_	_	_	_	_	_	_	_
77	China	_	_	_	_	_	_	_	_
78	's	_	_	_	_	_	_	_	_
79	rapid	_	_	_	_	_	_	_	_
80	rise	_	_	_	_	_	_	_	_
81	to	_	_	_	_	_	_	_	BeginSeg=Yes
82	become	_	_	_	_	_	_	_	_
83	the	_	_	_	_	_	_	_	_
84-85	world's	_	_	_	_	_	_	_	_
84	world	_	_	_	_	_	_	_	_
85	's	_	_	_	_	_	_	_	_
86	second	_	_	_	_	_	_	_	_
87	largest	_	_	_	_	_	_	_	_
88	economy	_	_	_	_	_	_	_	_
89	.	_	_	_	_	_	_	_	_
90	With	_	_	_	_	_	_	_	BeginSeg=Yes
91	regard	_	_	_	_	_	_	_	_
92	to	_	_	_	_	_	_	_	_
93	the	_	_	_	_	_	_	_	_
94	motivations	_	_	_	_	_	_	_	_
95	behind	_	_	_	_	_	_	_	_
96	the	_	_	_	_	_	_	_	_
97	Chinese	_	_	_	_	_	_	_	_
98-99	government's	_	_	_	_	_	_	_	_
98	government	_	_	_	_	_	_	_	_
99	's	_	_	_	_	_	_	_	_
100	support	_	_	_	_	_	_	_	_
101	for	_	_	_	_	_	_	_	_
102	discursive	_	_	_	_	_	_	_	_
103	power	_	_	_	_	_	_	_	_
104	,	_	_	_	_	_	_	_	_
105	the	_	_	_	_	_	_	_	BeginSeg=Yes
106	dominant	_	_	_	_	_	_	_	_
107	explanation	_	_	_	_	_	_	_	_
108	is	_	_	_	_	_	_	_	_
109	based	_	_	_	_	_	_	_	_
110	on	_	_	_	_	_	_	_	_
111	the	_	_	_	_	_	_	_	_
112	'	_	_	_	_	_	_	_	_
113	'	_	_	_	_	_	_	_	_
114	rise	_	_	_	_	_	_	_	_
115	of	_	_	_	_	_	_	_	_
116	China	_	_	_	_	_	_	_	_
117	'	_	_	_	_	_	_	_	_
118	'	_	_	_	_	_	_	_	_
119	argument	_	_	_	_	_	_	_	_
120	.	_	_	_	_	_	_	_	_
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122	,	_	_	_	_	_	_	_	_
123	this	_	_	_	_	_	_	_	_
124	argument	_	_	_	_	_	_	_	_
125	does	_	_	_	_	_	_	_	_
126	not	_	_	_	_	_	_	_	_
127	explain	_	_	_	_	_	_	_	_
128	the	_	_	_	_	_	_	_	_
129	causal	_	_	_	_	_	_	_	_
130	relationship	_	_	_	_	_	_	_	_
131	between	_	_	_	_	_	_	_	_
132-133	China's	_	_	_	_	_	_	_	_
132	China	_	_	_	_	_	_	_	_
133	's	_	_	_	_	_	_	_	_
134	rise	_	_	_	_	_	_	_	_
135	and	_	_	_	_	_	_	_	_
136	its	_	_	_	_	_	_	_	_
137	discursive	_	_	_	_	_	_	_	_
138	power	_	_	_	_	_	_	_	_
139	strategy	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	So	_	_	_	_	_	_	_	BeginSeg=Yes
142	,	_	_	_	_	_	_	_	_
143	this	_	_	_	_	_	_	_	_
144	paper	_	_	_	_	_	_	_	_
145	aims	_	_	_	_	_	_	_	_
146	to	_	_	_	_	_	_	_	_
147	clarify	_	_	_	_	_	_	_	_
148	the	_	_	_	_	_	_	_	_
149	motivation	_	_	_	_	_	_	_	_
150	behind	_	_	_	_	_	_	_	_
151-152	China's	_	_	_	_	_	_	_	_
151	China	_	_	_	_	_	_	_	_
152	's	_	_	_	_	_	_	_	_
153	discursive	_	_	_	_	_	_	_	_
154	power	_	_	_	_	_	_	_	_
155	strategy	_	_	_	_	_	_	_	_
156	through	_	_	_	_	_	_	_	_
157	document	_	_	_	_	_	_	_	_
158	reviews	_	_	_	_	_	_	_	_
159	and	_	_	_	_	_	_	_	_
160	interviews	_	_	_	_	_	_	_	_
161	with	_	_	_	_	_	_	_	_
162	mainstream	_	_	_	_	_	_	_	_
163	scholars	_	_	_	_	_	_	_	_
164	.	_	_	_	_	_	_	_	_
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166	concludes	_	_	_	_	_	_	_	_
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169	discursive	_	_	_	_	_	_	_	_
170	power	_	_	_	_	_	_	_	_
171	strategy	_	_	_	_	_	_	_	_
172	has	_	_	_	_	_	_	_	_
173	been	_	_	_	_	_	_	_	_
174	the	_	_	_	_	_	_	_	_
175	fundamental	_	_	_	_	_	_	_	_
176	principle	_	_	_	_	_	_	_	_
177	of	_	_	_	_	_	_	_	_
178	the	_	_	_	_	_	_	_	_
179	Communist	_	_	_	_	_	_	_	_
180	Party	_	_	_	_	_	_	_	_
181	of	_	_	_	_	_	_	_	_
182	China	_	_	_	_	_	_	_	_
183	since	_	_	_	_	_	_	_	_
184	its	_	_	_	_	_	_	_	_
185	establishment	_	_	_	_	_	_	_	_
186	in	_	_	_	_	_	_	_	_
187	1921	_	_	_	_	_	_	_	_
188	.	_	_	_	_	_	_	_	_
189	Since	_	_	_	_	_	_	_	BeginSeg=Yes
190-191	China's	_	_	_	_	_	_	_	_
190	China	_	_	_	_	_	_	_	_
191	's	_	_	_	_	_	_	_	_
192	adoption	_	_	_	_	_	_	_	_
193	of	_	_	_	_	_	_	_	_
194	an	_	_	_	_	_	_	_	_
195	opening	_	_	_	_	_	_	_	_
196	-	_	_	_	_	_	_	_	_
197	up	_	_	_	_	_	_	_	_
198	policy	_	_	_	_	_	_	_	_
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200	1978	_	_	_	_	_	_	_	_
201	,	_	_	_	_	_	_	_	_
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204	has	_	_	_	_	_	_	_	_
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206	suppressed	_	_	_	_	_	_	_	_
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208	not	_	_	_	_	_	_	_	_
209	eliminated	_	_	_	_	_	_	_	_
210	entirely	_	_	_	_	_	_	_	_
211	by	_	_	_	_	_	_	_	_
212	top	_	_	_	_	_	_	_	_
213	leaders	_	_	_	_	_	_	_	_
214	.	_	_	_	_	_	_	_	_
215	As	_	_	_	_	_	_	_	BeginSeg=Yes
216	China	_	_	_	_	_	_	_	_
217	continues	_	_	_	_	_	_	_	_
218	to	_	_	_	_	_	_	_	_
219	rise	_	_	_	_	_	_	_	_
220	on	_	_	_	_	_	_	_	_
221	the	_	_	_	_	_	_	_	_
222	world	_	_	_	_	_	_	_	_
223	stage	_	_	_	_	_	_	_	_
224	,	_	_	_	_	_	_	_	_
225	the	_	_	_	_	_	_	_	BeginSeg=Yes
226	principle	_	_	_	_	_	_	_	_
227	will	_	_	_	_	_	_	_	_
228	drive	_	_	_	_	_	_	_	_
229	China	_	_	_	_	_	_	_	_
230	to	_	_	_	_	_	_	_	_
231	create	_	_	_	_	_	_	_	_
232	a	_	_	_	_	_	_	_	_
233	new	_	_	_	_	_	_	_	_
234	political	_	_	_	_	_	_	_	_
235	model	_	_	_	_	_	_	_	_
236	rather	_	_	_	_	_	_	_	BeginSeg=Yes
237	than	_	_	_	_	_	_	_	_
238	be	_	_	_	_	_	_	_	_
239	a	_	_	_	_	_	_	_	_
240	mere	_	_	_	_	_	_	_	_
241	follower	_	_	_	_	_	_	_	_
242	of	_	_	_	_	_	_	_	_
243	the	_	_	_	_	_	_	_	_
244	established	_	_	_	_	_	_	_	_
245	political	_	_	_	_	_	_	_	_
246	order	_	_	_	_	_	_	_	_
247	.	_	_	_	_	_	_	_	_

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3	vaccines	_	_	_	_	_	_	_	_
4	provide	_	_	_	_	_	_	_	_
5	a	_	_	_	_	_	_	_	_
6	new	_	_	_	_	_	_	_	_
7	way	_	_	_	_	_	_	_	_
8	of	_	_	_	_	_	_	_	BeginSeg=Yes
9	controlling	_	_	_	_	_	_	_	_
10	rotavirus	_	_	_	_	_	_	_	_
11	in	_	_	_	_	_	_	_	_
12	sub	_	_	_	_	_	_	_	_
13	-	_	_	_	_	_	_	_	_
14	Saharan	_	_	_	_	_	_	_	_
15	Africa	_	_	_	_	_	_	_	_
16	.	_	_	_	_	_	_	_	_
17	Models	_	_	_	_	_	_	_	BeginSeg=Yes
18	for	_	_	_	_	_	_	_	_
19	the	_	_	_	_	_	_	_	_
20	transmission	_	_	_	_	_	_	_	_
21	dynamics	_	_	_	_	_	_	_	_
22	of	_	_	_	_	_	_	_	_
23	rotavirus	_	_	_	_	_	_	_	_
24	are	_	_	_	_	_	_	_	_
25	critical	_	_	_	_	_	_	_	_
26	both	_	_	_	_	_	_	_	BeginSeg=Yes
27	for	_	_	_	_	_	_	_	_
28	estimating	_	_	_	_	_	_	_	_
29	current	_	_	_	_	_	_	_	_
30	burden	_	_	_	_	_	_	_	_
31	from	_	_	_	_	_	_	_	_
32	imperfect	_	_	_	_	_	_	_	_
33	surveillance	_	_	_	_	_	_	_	_
34	and	_	_	_	_	_	_	_	BeginSeg=Yes
35	for	_	_	_	_	_	_	_	_
36	assessing	_	_	_	_	_	_	_	_
37	potential	_	_	_	_	_	_	_	_
38	effects	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	vaccine	_	_	_	_	_	_	_	_
41	intervention	_	_	_	_	_	_	_	_
42	strategies	_	_	_	_	_	_	_	_
43	.	_	_	_	_	_	_	_	_
44	We	_	_	_	_	_	_	_	BeginSeg=Yes
45	examine	_	_	_	_	_	_	_	_
46	rotavirus	_	_	_	_	_	_	_	_
47	infection	_	_	_	_	_	_	_	_
48	in	_	_	_	_	_	_	_	_
49	the	_	_	_	_	_	_	_	_
50	Maradi	_	_	_	_	_	_	_	_
51	area	_	_	_	_	_	_	_	_
52	in	_	_	_	_	_	_	_	_
53	southern	_	_	_	_	_	_	_	_
54	Niger	_	_	_	_	_	_	_	_
55	using	_	_	_	_	_	_	_	BeginSeg=Yes
56	hospital	_	_	_	_	_	_	_	_
57	surveillance	_	_	_	_	_	_	_	_
58	data	_	_	_	_	_	_	_	_
59	provided	_	_	_	_	_	_	_	BeginSeg=Yes
60	by	_	_	_	_	_	_	_	_
61	Epicentre	_	_	_	_	_	_	_	_
62	collected	_	_	_	_	_	_	_	BeginSeg=Yes
63	over	_	_	_	_	_	_	_	_
64	two	_	_	_	_	_	_	_	_
65	years	_	_	_	_	_	_	_	_
66	.	_	_	_	_	_	_	_	_
67	Additionally	_	_	_	_	_	_	_	BeginSeg=Yes
68	,	_	_	_	_	_	_	_	_
69	a	_	_	_	_	_	_	_	_
70	cluster	_	_	_	_	_	_	_	_
71	survey	_	_	_	_	_	_	_	_
72	of	_	_	_	_	_	_	_	_
73	households	_	_	_	_	_	_	_	_
74	in	_	_	_	_	_	_	_	_
75	the	_	_	_	_	_	_	_	_
76	region	_	_	_	_	_	_	_	_
77	allows	_	_	_	_	_	_	_	_
78	us	_	_	_	_	_	_	_	_
79	to	_	_	_	_	_	_	_	_
80	estimate	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	proportion	_	_	_	_	_	_	_	_
83	of	_	_	_	_	_	_	_	_
84	children	_	_	_	_	_	_	_	_
85	with	_	_	_	_	_	_	_	_
86	diarrhea	_	_	_	_	_	_	_	_
87	who	_	_	_	_	_	_	_	BeginSeg=Yes
88	consulted	_	_	_	_	_	_	_	_
89	at	_	_	_	_	_	_	_	_
90	a	_	_	_	_	_	_	_	_
91	health	_	_	_	_	_	_	_	_
92	structure	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_
94	Model	_	_	_	_	_	_	_	BeginSeg=Yes
95	fit	_	_	_	_	_	_	_	_
96	and	_	_	_	_	_	_	_	_
97	future	_	_	_	_	_	_	_	_
98	projections	_	_	_	_	_	_	_	_
99	are	_	_	_	_	_	_	_	_
100	necessarily	_	_	_	_	_	_	_	_
101	particular	_	_	_	_	_	_	_	_
102	to	_	_	_	_	_	_	_	_
103	a	_	_	_	_	_	_	_	_
104	given	_	_	_	_	_	_	_	_
105	model	_	_	_	_	_	_	_	_
106	;	_	_	_	_	_	_	_	_
107	thus	_	_	_	_	_	_	_	BeginSeg=Yes
108	,	_	_	_	_	_	_	_	_
109	where	_	_	_	_	_	_	_	_
110	there	_	_	_	_	_	_	_	_
111	are	_	_	_	_	_	_	_	_
112	competing	_	_	_	_	_	_	_	_
113	models	_	_	_	_	_	_	_	_
114	for	_	_	_	_	_	_	_	_
115	the	_	_	_	_	_	_	_	_
116	underlying	_	_	_	_	_	_	_	_
117	epidemiology	_	_	_	_	_	_	_	_
118	an	_	_	_	_	_	_	_	BeginSeg=Yes
119	ensemble	_	_	_	_	_	_	_	_
120	approach	_	_	_	_	_	_	_	_
121	can	_	_	_	_	_	_	_	_
122	account	_	_	_	_	_	_	_	_
123	for	_	_	_	_	_	_	_	_
124	that	_	_	_	_	_	_	_	_
125	uncertainty	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_
127	We	_	_	_	_	_	_	_	BeginSeg=Yes
128	compare	_	_	_	_	_	_	_	_
129	our	_	_	_	_	_	_	_	_
130	results	_	_	_	_	_	_	_	_
131	across	_	_	_	_	_	_	_	_
132	several	_	_	_	_	_	_	_	_
133	variants	_	_	_	_	_	_	_	_
134	of	_	_	_	_	_	_	_	_
135	Susceptible	_	_	_	_	_	_	_	_
136	-	_	_	_	_	_	_	_	_
137	Infectious	_	_	_	_	_	_	_	_
138	-	_	_	_	_	_	_	_	_
139	Recovered	_	_	_	_	_	_	_	_
140	(	_	_	_	_	_	_	_	_
141	SIR	_	_	_	_	_	_	_	_
142	)	_	_	_	_	_	_	_	_
143	compartmental	_	_	_	_	_	_	_	_
144	models	_	_	_	_	_	_	_	_
145	to	_	_	_	_	_	_	_	BeginSeg=Yes
146	quantify	_	_	_	_	_	_	_	_
147	the	_	_	_	_	_	_	_	_
148	impact	_	_	_	_	_	_	_	_
149	of	_	_	_	_	_	_	_	_
150	modeling	_	_	_	_	_	_	_	_
151	assumptions	_	_	_	_	_	_	_	_
152	on	_	_	_	_	_	_	_	_
153	our	_	_	_	_	_	_	_	_
154	estimates	_	_	_	_	_	_	_	_
155	.	_	_	_	_	_	_	_	_
156	Model	_	_	_	_	_	_	_	BeginSeg=Yes
157	-	_	_	_	_	_	_	_	_
158	specific	_	_	_	_	_	_	_	_
159	parameters	_	_	_	_	_	_	_	_
160	are	_	_	_	_	_	_	_	_
161	estimated	_	_	_	_	_	_	_	_
162	by	_	_	_	_	_	_	_	_
163	Bayesian	_	_	_	_	_	_	_	_
164	inference	_	_	_	_	_	_	_	_
165	using	_	_	_	_	_	_	_	BeginSeg=Yes
166	Markov	_	_	_	_	_	_	_	_
167	chain	_	_	_	_	_	_	_	_
168	Monte	_	_	_	_	_	_	_	_
169	Carlo	_	_	_	_	_	_	_	_
170	.	_	_	_	_	_	_	_	_
171	We	_	_	_	_	_	_	_	BeginSeg=Yes
172	then	_	_	_	_	_	_	_	_
173	use	_	_	_	_	_	_	_	_
174	Bayesian	_	_	_	_	_	_	_	_
175	model	_	_	_	_	_	_	_	_
176	averaging	_	_	_	_	_	_	_	_
177	to	_	_	_	_	_	_	_	BeginSeg=Yes
178	generate	_	_	_	_	_	_	_	_
179	ensemble	_	_	_	_	_	_	_	_
180	estimates	_	_	_	_	_	_	_	_
181	of	_	_	_	_	_	_	_	_
182	the	_	_	_	_	_	_	_	_
183	current	_	_	_	_	_	_	_	_
184	dynamics	_	_	_	_	_	_	_	_
185	,	_	_	_	_	_	_	_	_
186	including	_	_	_	_	_	_	_	BeginSeg=Yes
187	estimates	_	_	_	_	_	_	_	_
188	of	_	_	_	_	_	_	_	_
189	R	_	_	_	_	_	_	_	_
190	0	_	_	_	_	_	_	_	_
191	,	_	_	_	_	_	_	_	_
192	the	_	_	_	_	_	_	_	_
193	burden	_	_	_	_	_	_	_	_
194	of	_	_	_	_	_	_	_	_
195	infection	_	_	_	_	_	_	_	_
196	in	_	_	_	_	_	_	_	_
197	the	_	_	_	_	_	_	_	_
198	region	_	_	_	_	_	_	_	_
199	,	_	_	_	_	_	_	_	_
200	as	_	_	_	_	_	_	_	_
201	well	_	_	_	_	_	_	_	_
202	as	_	_	_	_	_	_	_	_
203	the	_	_	_	_	_	_	_	_
204	impact	_	_	_	_	_	_	_	_
205	of	_	_	_	_	_	_	_	_
206	vaccination	_	_	_	_	_	_	_	_
207	on	_	_	_	_	_	_	_	_
208	both	_	_	_	_	_	_	_	_
209	the	_	_	_	_	_	_	_	_
210	short	_	_	_	_	_	_	_	_
211	-	_	_	_	_	_	_	_	_
212	term	_	_	_	_	_	_	_	_
213	dynamics	_	_	_	_	_	_	_	_
214	and	_	_	_	_	_	_	_	_
215	the	_	_	_	_	_	_	_	_
216	long	_	_	_	_	_	_	_	_
217	-	_	_	_	_	_	_	_	_
218	term	_	_	_	_	_	_	_	_
219	reduction	_	_	_	_	_	_	_	_
220	of	_	_	_	_	_	_	_	_
221	rotavirus	_	_	_	_	_	_	_	_
222	incidence	_	_	_	_	_	_	_	_
223	under	_	_	_	_	_	_	_	_
224	varying	_	_	_	_	_	_	_	_
225	levels	_	_	_	_	_	_	_	_
226	of	_	_	_	_	_	_	_	_
227	coverage	_	_	_	_	_	_	_	_
228	.	_	_	_	_	_	_	_	_
229	The	_	_	_	_	_	_	_	BeginSeg=Yes
230	ensemble	_	_	_	_	_	_	_	_
231	of	_	_	_	_	_	_	_	_
232	models	_	_	_	_	_	_	_	_
233	predicts	_	_	_	_	_	_	_	_
234	that	_	_	_	_	_	_	_	BeginSeg=Yes
235	the	_	_	_	_	_	_	_	_
236	current	_	_	_	_	_	_	_	_
237	burden	_	_	_	_	_	_	_	_
238	of	_	_	_	_	_	_	_	_
239	severe	_	_	_	_	_	_	_	_
240	rotavirus	_	_	_	_	_	_	_	_
241	disease	_	_	_	_	_	_	_	_
242	is	_	_	_	_	_	_	_	_
243	2.6	_	_	_	_	_	_	_	_
244	-	_	_	_	_	_	_	_	_
245	3.7	_	_	_	_	_	_	_	_
246	%	_	_	_	_	_	_	_	_
247	of	_	_	_	_	_	_	_	_
248	the	_	_	_	_	_	_	_	_
249	population	_	_	_	_	_	_	_	_
250	each	_	_	_	_	_	_	_	_
251	year	_	_	_	_	_	_	_	_
252	and	_	_	_	_	_	_	_	BeginSeg=Yes
253	that	_	_	_	_	_	_	_	_
254	a	_	_	_	_	_	_	_	_
255	2-dose	_	_	_	_	_	_	_	_
256	vaccine	_	_	_	_	_	_	_	_
257	schedule	_	_	_	_	_	_	_	_
258	achieving	_	_	_	_	_	_	_	_
259	70	_	_	_	_	_	_	_	_
260	%	_	_	_	_	_	_	_	_
261	coverage	_	_	_	_	_	_	_	_
262	could	_	_	_	_	_	_	_	_
263	reduce	_	_	_	_	_	_	_	_
264	burden	_	_	_	_	_	_	_	_
265	by	_	_	_	_	_	_	_	_
266	39	_	_	_	_	_	_	_	_
267	-	_	_	_	_	_	_	_	_
268	42	_	_	_	_	_	_	_	_
269	%	_	_	_	_	_	_	_	_
270	.	_	_	_	_	_	_	_	_

# newdoc_id = c74ce5464f754301499d7537e87810f46e69c454
1	The	_	_	_	_	_	_	_	BeginSeg=Yes
2	mechanisms	_	_	_	_	_	_	_	_
3	of	_	_	_	_	_	_	_	_
4	inflammation	_	_	_	_	_	_	_	_
5	and	_	_	_	_	_	_	_	_
6	cancer	_	_	_	_	_	_	_	_
7	are	_	_	_	_	_	_	_	_
8	intertwined	_	_	_	_	_	_	_	_
9	by	_	_	_	_	_	_	_	_
10	complex	_	_	_	_	_	_	_	_
11	networks	_	_	_	_	_	_	_	_
12	of	_	_	_	_	_	_	_	_
13	signaling	_	_	_	_	_	_	_	_
14	pathways	_	_	_	_	_	_	_	_
15	.	_	_	_	_	_	_	_	_
16	Dysregulations	_	_	_	_	_	_	_	BeginSeg=Yes
17	in	_	_	_	_	_	_	_	_
18	the	_	_	_	_	_	_	_	_
19	Janus	_	_	_	_	_	_	_	_
20	kinase	_	_	_	_	_	_	_	_
21	/	_	_	_	_	_	_	_	_
22	signal	_	_	_	_	_	_	_	_
23	transducer	_	_	_	_	_	_	_	_
24	and	_	_	_	_	_	_	_	_
25	activator	_	_	_	_	_	_	_	_
26	of	_	_	_	_	_	_	_	_
27	transcription	_	_	_	_	_	_	_	_
28	(	_	_	_	_	_	_	_	_
29	JAK	_	_	_	_	_	_	_	_
30	/	_	_	_	_	_	_	_	_
31	STAT	_	_	_	_	_	_	_	_
32	)	_	_	_	_	_	_	_	_
33	pathway	_	_	_	_	_	_	_	_
34	underlie	_	_	_	_	_	_	_	_
35	several	_	_	_	_	_	_	_	_
36	pathogenic	_	_	_	_	_	_	_	_
37	conditions	_	_	_	_	_	_	_	_
38	related	_	_	_	_	_	_	_	BeginSeg=Yes
39	to	_	_	_	_	_	_	_	_
40	chronic	_	_	_	_	_	_	_	_
41	inflammatory	_	_	_	_	_	_	_	_
42	states	_	_	_	_	_	_	_	_
43	,	_	_	_	_	_	_	_	_
44	autoimmune	_	_	_	_	_	_	_	_
45	diseases	_	_	_	_	_	_	_	_
46	and	_	_	_	_	_	_	_	_
47	cancer	_	_	_	_	_	_	_	_
48	.	_	_	_	_	_	_	_	_
49	Historically	_	_	_	_	_	_	_	BeginSeg=Yes
50	,	_	_	_	_	_	_	_	_
51	the	_	_	_	_	_	_	_	_
52	potential	_	_	_	_	_	_	_	_
53	application	_	_	_	_	_	_	_	_
54	of	_	_	_	_	_	_	_	_
55	JAK	_	_	_	_	_	_	_	_
56	inhibition	_	_	_	_	_	_	_	_
57	has	_	_	_	_	_	_	_	_
58	been	_	_	_	_	_	_	_	_
59	thoroughly	_	_	_	_	_	_	_	_
60	explored	_	_	_	_	_	_	_	_
61	,	_	_	_	_	_	_	_	_
62	thus	_	_	_	_	_	_	_	BeginSeg=Yes
63	triggering	_	_	_	_	_	_	_	_
64	an	_	_	_	_	_	_	_	_
65	escalation	_	_	_	_	_	_	_	_
66	of	_	_	_	_	_	_	_	_
67	favorable	_	_	_	_	_	_	_	_
68	results	_	_	_	_	_	_	_	_
69	in	_	_	_	_	_	_	_	_
70	this	_	_	_	_	_	_	_	_
71	field	_	_	_	_	_	_	_	_
72	.	_	_	_	_	_	_	_	_
73	So	_	_	_	_	_	_	_	BeginSeg=Yes
74	far	_	_	_	_	_	_	_	_
75	,	_	_	_	_	_	_	_	_
76	five	_	_	_	_	_	_	_	_
77	JAK	_	_	_	_	_	_	_	_
78	inhibitors	_	_	_	_	_	_	_	_
79	have	_	_	_	_	_	_	_	_
80	been	_	_	_	_	_	_	_	_
81	approved	_	_	_	_	_	_	_	_
82	by	_	_	_	_	_	_	_	_
83	the	_	_	_	_	_	_	_	_
84	Food	_	_	_	_	_	_	_	_
85	and	_	_	_	_	_	_	_	_
86	Drug	_	_	_	_	_	_	_	_
87	Administration	_	_	_	_	_	_	_	_
88	(	_	_	_	_	_	_	_	_
89	FDA	_	_	_	_	_	_	_	_
90	)	_	_	_	_	_	_	_	_
91	for	_	_	_	_	_	_	_	_
92	the	_	_	_	_	_	_	_	_
93	treatment	_	_	_	_	_	_	_	_
94	of	_	_	_	_	_	_	_	_
95	different	_	_	_	_	_	_	_	_
96	diseases	_	_	_	_	_	_	_	_
97	.	_	_	_	_	_	_	_	_
98	Considering	_	_	_	_	_	_	_	BeginSeg=Yes
99	the	_	_	_	_	_	_	_	_
100	complexity	_	_	_	_	_	_	_	_
101	of	_	_	_	_	_	_	_	_
102	JAK	_	_	_	_	_	_	_	_
103	-	_	_	_	_	_	_	_	_
104	depending	_	_	_	_	_	_	_	_
105	processes	_	_	_	_	_	_	_	_
106	and	_	_	_	_	_	_	_	_
107	their	_	_	_	_	_	_	_	_
108	involvement	_	_	_	_	_	_	_	_
109	in	_	_	_	_	_	_	_	_
110	multiple	_	_	_	_	_	_	_	_
111	disorders	_	_	_	_	_	_	_	_
112	,	_	_	_	_	_	_	_	_
113	JAK	_	_	_	_	_	_	_	BeginSeg=Yes
114	inhibitors	_	_	_	_	_	_	_	_
115	are	_	_	_	_	_	_	_	_
116	the	_	_	_	_	_	_	_	_
117	perfect	_	_	_	_	_	_	_	_
118	candidates	_	_	_	_	_	_	_	_
119	for	_	_	_	_	_	_	_	_
120	drug	_	_	_	_	_	_	_	_
121	repurposing	_	_	_	_	_	_	_	_
122	and	_	_	_	_	_	_	_	_
123	for	_	_	_	_	_	_	_	_
124	the	_	_	_	_	_	_	_	_
125	assessment	_	_	_	_	_	_	_	_
126	of	_	_	_	_	_	_	_	_
127	multitarget	_	_	_	_	_	_	_	_
128	strategies	_	_	_	_	_	_	_	_
129	.	_	_	_	_	_	_	_	_
130	Herein	_	_	_	_	_	_	_	BeginSeg=Yes
131	we	_	_	_	_	_	_	_	_
132	reviewed	_	_	_	_	_	_	_	_
133	the	_	_	_	_	_	_	_	_
134	recent	_	_	_	_	_	_	_	_
135	progress	_	_	_	_	_	_	_	_
136	concerning	_	_	_	_	_	_	_	BeginSeg=Yes
137	JAK	_	_	_	_	_	_	_	_
138	inhibition	_	_	_	_	_	_	_	_
139	,	_	_	_	_	_	_	_	_
140	including	_	_	_	_	_	_	_	BeginSeg=Yes
141	the	_	_	_	_	_	_	_	_
142	innovations	_	_	_	_	_	_	_	_
143	provided	_	_	_	_	_	_	_	BeginSeg=Yes
144	by	_	_	_	_	_	_	_	_
145	the	_	_	_	_	_	_	_	_
146	release	_	_	_	_	_	_	_	_
147	of	_	_	_	_	_	_	_	_
148	JAKs	_	_	_	_	_	_	_	_
149	crystal	_	_	_	_	_	_	_	_
150	structures	_	_	_	_	_	_	_	_
151	and	_	_	_	_	_	_	_	BeginSeg=Yes
152	the	_	_	_	_	_	_	_	_
153	improvement	_	_	_	_	_	_	_	_
154	of	_	_	_	_	_	_	_	_
155	synthetic	_	_	_	_	_	_	_	_
156	strategies	_	_	_	_	_	_	_	_
157	aimed	_	_	_	_	_	_	_	BeginSeg=Yes
158	to	_	_	_	_	_	_	_	_
159	simplify	_	_	_	_	_	_	_	_
160	of	_	_	_	_	_	_	_	_
161	the	_	_	_	_	_	_	_	_
162	industrial	_	_	_	_	_	_	_	_
163	scale	_	_	_	_	_	_	_	_
164	-	_	_	_	_	_	_	_	_
165	up	_	_	_	_	_	_	_	_
166	.	_	_	_	_	_	_	_	_

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1	Compelling	_	_	_	_	_	_	_	BeginSeg=Yes
2	evidence	_	_	_	_	_	_	_	_
3	supports	_	_	_	_	_	_	_	_
4	the	_	_	_	_	_	_	_	_
5	role	_	_	_	_	_	_	_	_
6	of	_	_	_	_	_	_	_	_
7	oxidative	_	_	_	_	_	_	_	_
8	stress	_	_	_	_	_	_	_	_
9	in	_	_	_	_	_	_	_	_
10-11	Alzheimer's	_	_	_	_	_	_	_	_
10	Alzheimer	_	_	_	_	_	_	_	_
11	's	_	_	_	_	_	_	_	_
12	disease	_	_	_	_	_	_	_	_
13	(	_	_	_	_	_	_	_	_
14	AD	_	_	_	_	_	_	_	_
15	)	_	_	_	_	_	_	_	_
16	pathophysiology	_	_	_	_	_	_	_	_
17	.	_	_	_	_	_	_	_	_
18	Interestingly	_	_	_	_	_	_	_	BeginSeg=Yes
19	,	_	_	_	_	_	_	_	_
20	Herpes	_	_	_	_	_	_	_	_
21	simplex	_	_	_	_	_	_	_	_
22	virus-1	_	_	_	_	_	_	_	_
23	(	_	_	_	_	_	_	_	_
24	HSV-1	_	_	_	_	_	_	_	_
25	)	_	_	_	_	_	_	_	_
26	,	_	_	_	_	_	_	_	_
27	a	_	_	_	_	_	_	_	_
28	neurotropic	_	_	_	_	_	_	_	_
29	virus	_	_	_	_	_	_	_	_
30	that	_	_	_	_	_	_	_	BeginSeg=Yes
31	establishes	_	_	_	_	_	_	_	_
32	a	_	_	_	_	_	_	_	_
33	lifelong	_	_	_	_	_	_	_	_
34	latent	_	_	_	_	_	_	_	_
35	infection	_	_	_	_	_	_	_	_
36	in	_	_	_	_	_	_	_	_
37	the	_	_	_	_	_	_	_	_
38	trigeminal	_	_	_	_	_	_	_	_
39	ganglion	_	_	_	_	_	_	_	_
40	followed	_	_	_	_	_	_	_	BeginSeg=Yes
41	by	_	_	_	_	_	_	_	_
42	periodic	_	_	_	_	_	_	_	_
43	reactivations	_	_	_	_	_	_	_	_
44	,	_	_	_	_	_	_	_	_
45	has	_	_	_	_	_	_	_	BeginSeg=Yes
46	been	_	_	_	_	_	_	_	_
47	reportedly	_	_	_	_	_	_	_	_
48	linked	_	_	_	_	_	_	_	_
49	both	_	_	_	_	_	_	_	_
50	to	_	_	_	_	_	_	_	_
51	AD	_	_	_	_	_	_	_	_
52	and	_	_	_	_	_	_	_	_
53	to	_	_	_	_	_	_	_	_
54	oxidative	_	_	_	_	_	_	_	_
55	stress	_	_	_	_	_	_	_	_
56	conditions	_	_	_	_	_	_	_	_
57	.	_	_	_	_	_	_	_	_
58	Herein	_	_	_	_	_	_	_	BeginSeg=Yes
59	,	_	_	_	_	_	_	_	_
60	we	_	_	_	_	_	_	_	_
61	analyzed	_	_	_	_	_	_	_	_
62	,	_	_	_	_	_	_	_	_
63	through	_	_	_	_	_	_	_	_
64	biochemical	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	_
66	redox	_	_	_	_	_	_	_	_
67	proteomic	_	_	_	_	_	_	_	_
68	approaches	_	_	_	_	_	_	_	_
69	,	_	_	_	_	_	_	_	_
70	the	_	_	_	_	_	_	_	_
71	mouse	_	_	_	_	_	_	_	_
72	model	_	_	_	_	_	_	_	_
73	of	_	_	_	_	_	_	_	_
74	recurrent	_	_	_	_	_	_	_	_
75	HSV-1	_	_	_	_	_	_	_	_
76	infection	_	_	_	_	_	_	_	_
77	we	_	_	_	_	_	_	_	BeginSeg=Yes
78	previously	_	_	_	_	_	_	_	_
79	set	_	_	_	_	_	_	_	_
80	up	_	_	_	_	_	_	_	_
81	,	_	_	_	_	_	_	_	_
82	to	_	_	_	_	_	_	_	BeginSeg=Yes
83	investigate	_	_	_	_	_	_	_	_
84	whether	_	_	_	_	_	_	_	_
85	multiple	_	_	_	_	_	_	_	_
86	virus	_	_	_	_	_	_	_	_
87	reactivations	_	_	_	_	_	_	_	_
88	induced	_	_	_	_	_	_	_	_
89	oxidative	_	_	_	_	_	_	_	_
90	stress	_	_	_	_	_	_	_	_
91	in	_	_	_	_	_	_	_	_
92	the	_	_	_	_	_	_	_	_
93	mouse	_	_	_	_	_	_	_	_
94	brain	_	_	_	_	_	_	_	_
95	and	_	_	_	_	_	_	_	_
96	affected	_	_	_	_	_	_	_	_
97	protein	_	_	_	_	_	_	_	_
98	function	_	_	_	_	_	_	_	_
99	and	_	_	_	_	_	_	_	_
100	related	_	_	_	_	_	_	_	_
101	intracellular	_	_	_	_	_	_	_	_
102	pathways	_	_	_	_	_	_	_	_
103	.	_	_	_	_	_	_	_	_
104	Following	_	_	_	_	_	_	_	BeginSeg=Yes
105	multiple	_	_	_	_	_	_	_	_
106	HSV-1	_	_	_	_	_	_	_	_
107	reactivations	_	_	_	_	_	_	_	_
108	,	_	_	_	_	_	_	_	_
109	we	_	_	_	_	_	_	_	BeginSeg=Yes
110	found	_	_	_	_	_	_	_	_
111	in	_	_	_	_	_	_	_	_
112	mouse	_	_	_	_	_	_	_	_
113	brains	_	_	_	_	_	_	_	_
114	increased	_	_	_	_	_	_	_	_
115	levels	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	oxidative	_	_	_	_	_	_	_	_
118	stress	_	_	_	_	_	_	_	_
119	hallmarks	_	_	_	_	_	_	_	_
120	,	_	_	_	_	_	_	_	_
121	including	_	_	_	_	_	_	_	BeginSeg=Yes
122	4-hydroxynonenal	_	_	_	_	_	_	_	_
123	(	_	_	_	_	_	_	_	_
124	HNE	_	_	_	_	_	_	_	_
125	)	_	_	_	_	_	_	_	_
126	,	_	_	_	_	_	_	_	_
127	and	_	_	_	_	_	_	_	_
128	13	_	_	_	_	_	_	_	_
129	HNE	_	_	_	_	_	_	_	_
130	-	_	_	_	_	_	_	_	_
131	modified	_	_	_	_	_	_	_	_
132	proteins	_	_	_	_	_	_	_	_
133	whose	_	_	_	_	_	_	_	BeginSeg=Yes
134	levels	_	_	_	_	_	_	_	_
135	were	_	_	_	_	_	_	_	_
136	found	_	_	_	_	_	_	_	_
137	significantly	_	_	_	_	_	_	_	_
138	altered	_	_	_	_	_	_	_	_
139	in	_	_	_	_	_	_	_	_
140	the	_	_	_	_	_	_	_	_
141	cortex	_	_	_	_	_	_	_	_
142	of	_	_	_	_	_	_	_	_
143	HSV-1-infected	_	_	_	_	_	_	_	_
144	mice	_	_	_	_	_	_	_	_
145	compared	_	_	_	_	_	_	_	BeginSeg=Yes
146	to	_	_	_	_	_	_	_	_
147	controls	_	_	_	_	_	_	_	_
148	.	_	_	_	_	_	_	_	_
149	We	_	_	_	_	_	_	_	BeginSeg=Yes
150	focused	_	_	_	_	_	_	_	_
151	on	_	_	_	_	_	_	_	_
152	two	_	_	_	_	_	_	_	_
153	proteins	_	_	_	_	_	_	_	_
154	previously	_	_	_	_	_	_	_	BeginSeg=Yes
155	linked	_	_	_	_	_	_	_	_
156	to	_	_	_	_	_	_	_	_
157	AD	_	_	_	_	_	_	_	_
158	pathogenesis	_	_	_	_	_	_	_	_
159	,	_	_	_	_	_	_	_	_
160	i.e.	_	_	_	_	_	_	_	BeginSeg=Yes
161	,	_	_	_	_	_	_	_	_
162	glucose	_	_	_	_	_	_	_	_
163	-	_	_	_	_	_	_	_	_
164	regulated	_	_	_	_	_	_	_	_
165	protein	_	_	_	_	_	_	_	_
166	78	_	_	_	_	_	_	_	_
167	(	_	_	_	_	_	_	_	_
168	GRP78	_	_	_	_	_	_	_	_
169	)	_	_	_	_	_	_	_	_
170	and	_	_	_	_	_	_	_	_
171	collapsin	_	_	_	_	_	_	_	_
172	response	_	_	_	_	_	_	_	_
173	-	_	_	_	_	_	_	_	_
174	mediated	_	_	_	_	_	_	_	_
175	protein	_	_	_	_	_	_	_	_
176	2	_	_	_	_	_	_	_	_
177	(	_	_	_	_	_	_	_	_
178	CRMP2	_	_	_	_	_	_	_	_
179	)	_	_	_	_	_	_	_	_
180	,	_	_	_	_	_	_	_	_
181	which	_	_	_	_	_	_	_	BeginSeg=Yes
182	are	_	_	_	_	_	_	_	_
183	involved	_	_	_	_	_	_	_	_
184	in	_	_	_	_	_	_	_	_
185	the	_	_	_	_	_	_	_	_
186	unfolded	_	_	_	_	_	_	_	_
187	protein	_	_	_	_	_	_	_	_
188	response	_	_	_	_	_	_	_	_
189	(	_	_	_	_	_	_	_	_
190	UPR	_	_	_	_	_	_	_	_
191	)	_	_	_	_	_	_	_	_
192	and	_	_	_	_	_	_	_	_
193	in	_	_	_	_	_	_	_	_
194	microtubule	_	_	_	_	_	_	_	_
195	stabilization	_	_	_	_	_	_	_	_
196	,	_	_	_	_	_	_	_	_
197	respectively	_	_	_	_	_	_	_	_
198	.	_	_	_	_	_	_	_	_
199	We	_	_	_	_	_	_	_	BeginSeg=Yes
200	found	_	_	_	_	_	_	_	_
201	that	_	_	_	_	_	_	_	BeginSeg=Yes
202	recurrent	_	_	_	_	_	_	_	_
203	HSV-1	_	_	_	_	_	_	_	_
204	infection	_	_	_	_	_	_	_	_
205	disables	_	_	_	_	_	_	_	_
206	GRP78	_	_	_	_	_	_	_	_
207	function	_	_	_	_	_	_	_	_
208	and	_	_	_	_	_	_	_	BeginSeg=Yes
209	activates	_	_	_	_	_	_	_	_
210	the	_	_	_	_	_	_	_	_
211	UPR	_	_	_	_	_	_	_	_
212	,	_	_	_	_	_	_	_	_
213	whereas	_	_	_	_	_	_	_	BeginSeg=Yes
214	it	_	_	_	_	_	_	_	_
215	prevents	_	_	_	_	_	_	_	_
216	CRMP2	_	_	_	_	_	_	_	_
217	function	_	_	_	_	_	_	_	_
218	in	_	_	_	_	_	_	_	_
219	mouse	_	_	_	_	_	_	_	_
220	brains	_	_	_	_	_	_	_	_
221	.	_	_	_	_	_	_	_	_
222	Overall	_	_	_	_	_	_	_	BeginSeg=Yes
223	,	_	_	_	_	_	_	_	_
224	these	_	_	_	_	_	_	_	_
225	data	_	_	_	_	_	_	_	_
226	suggest	_	_	_	_	_	_	_	_
227	that	_	_	_	_	_	_	_	BeginSeg=Yes
228	repeated	_	_	_	_	_	_	_	_
229	HSV-1	_	_	_	_	_	_	_	_
230	reactivation	_	_	_	_	_	_	_	_
231	into	_	_	_	_	_	_	_	_
232	the	_	_	_	_	_	_	_	_
233	brain	_	_	_	_	_	_	_	_
234	may	_	_	_	_	_	_	_	_
235	contribute	_	_	_	_	_	_	_	_
236	to	_	_	_	_	_	_	_	_
237	neurodegeneration	_	_	_	_	_	_	_	_
238	also	_	_	_	_	_	_	_	_
239	through	_	_	_	_	_	_	_	_
240	oxidative	_	_	_	_	_	_	_	_
241	damage	_	_	_	_	_	_	_	_
242	.	_	_	_	_	_	_	_	_

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2	:	_	_	_	_	_	_	_	_
3	Recent	_	_	_	_	_	_	_	BeginSeg=Yes
4	experiences	_	_	_	_	_	_	_	_
5	in	_	_	_	_	_	_	_	_
6	the	_	_	_	_	_	_	_	_
7	United	_	_	_	_	_	_	_	_
8	States	_	_	_	_	_	_	_	_
9	with	_	_	_	_	_	_	_	_
10	unprecedented	_	_	_	_	_	_	_	_
11	terrorist	_	_	_	_	_	_	_	_
12	attacks	_	_	_	_	_	_	_	_
13	(	_	_	_	_	_	_	_	_
14	9/11	_	_	_	_	_	_	_	_
15	)	_	_	_	_	_	_	_	_
16	and	_	_	_	_	_	_	_	_
17	a	_	_	_	_	_	_	_	_
18	devastating	_	_	_	_	_	_	_	_
19	natural	_	_	_	_	_	_	_	_
20	disaster	_	_	_	_	_	_	_	_
21	(	_	_	_	_	_	_	_	_
22	Hurricane	_	_	_	_	_	_	_	_
23	Katrina	_	_	_	_	_	_	_	_
24	)	_	_	_	_	_	_	_	_
25	have	_	_	_	_	_	_	_	_
26	demonstrated	_	_	_	_	_	_	_	_
27	that	_	_	_	_	_	_	_	BeginSeg=Yes
28	the	_	_	_	_	_	_	_	_
29	medical	_	_	_	_	_	_	_	_
30	care	_	_	_	_	_	_	_	_
31	of	_	_	_	_	_	_	_	_
32	mass	_	_	_	_	_	_	_	_
33	casualties	_	_	_	_	_	_	_	_
34	during	_	_	_	_	_	_	_	_
35	such	_	_	_	_	_	_	_	_
36	disasters	_	_	_	_	_	_	_	_
37	poses	_	_	_	_	_	_	_	_
38	ethical	_	_	_	_	_	_	_	_
39	problems	_	_	_	_	_	_	_	_
40	not	_	_	_	_	_	_	_	BeginSeg=Yes
41	normally	_	_	_	_	_	_	_	_
42	experienced	_	_	_	_	_	_	_	_
43	in	_	_	_	_	_	_	_	_
44	civilian	_	_	_	_	_	_	_	_
45	health	_	_	_	_	_	_	_	_
46	care	_	_	_	_	_	_	_	_
47	.	_	_	_	_	_	_	_	_
48	It	_	_	_	_	_	_	_	BeginSeg=Yes
49	is	_	_	_	_	_	_	_	_
50	important	_	_	_	_	_	_	_	_
51	to	_	_	_	_	_	_	_	_
52	1	_	_	_	_	_	_	_	_
53	)	_	_	_	_	_	_	_	_
54	identify	_	_	_	_	_	_	_	_
55	the	_	_	_	_	_	_	_	_
56	unique	_	_	_	_	_	_	_	_
57	ethical	_	_	_	_	_	_	_	_
58	challenges	_	_	_	_	_	_	_	_
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60	physicians	_	_	_	_	_	_	_	_
61	who	_	_	_	_	_	_	_	BeginSeg=Yes
62	feel	_	_	_	_	_	_	_	_
63	an	_	_	_	_	_	_	_	_
64	obligation	_	_	_	_	_	_	_	_
65	to	_	_	_	_	_	_	_	BeginSeg=Yes
66	care	_	_	_	_	_	_	_	_
67	for	_	_	_	_	_	_	_	_
68	victims	_	_	_	_	_	_	_	_
69	of	_	_	_	_	_	_	_	_
70	such	_	_	_	_	_	_	_	_
71	disasters	_	_	_	_	_	_	_	_
72	and	_	_	_	_	_	_	_	BeginSeg=Yes
73	2	_	_	_	_	_	_	_	_
74	)	_	_	_	_	_	_	_	_
75	develop	_	_	_	_	_	_	_	_
76	a	_	_	_	_	_	_	_	_
77	national	_	_	_	_	_	_	_	_
78	consensus	_	_	_	_	_	_	_	_
79	on	_	_	_	_	_	_	_	_
80	ethical	_	_	_	_	_	_	_	_
81	guidelines	_	_	_	_	_	_	_	_
82	as	_	_	_	_	_	_	_	_
83	a	_	_	_	_	_	_	_	_
84	resource	_	_	_	_	_	_	_	_
85	for	_	_	_	_	_	_	_	_
86	ethical	_	_	_	_	_	_	_	_
87	decision	_	_	_	_	_	_	_	_
88	making	_	_	_	_	_	_	_	_
89	in	_	_	_	_	_	_	_	_
90	medical	_	_	_	_	_	_	_	_
91	disaster	_	_	_	_	_	_	_	_
92	relief	_	_	_	_	_	_	_	_
93	.	_	_	_	_	_	_	_	_
94	STUDY	_	_	_	_	_	_	_	BeginSeg=Yes
95	DESIGN	_	_	_	_	_	_	_	_
96	:	_	_	_	_	_	_	_	_
97	A	_	_	_	_	_	_	_	BeginSeg=Yes
98	survey	_	_	_	_	_	_	_	_
99	of	_	_	_	_	_	_	_	_
100	pertinent	_	_	_	_	_	_	_	_
101	literature	_	_	_	_	_	_	_	_
102	was	_	_	_	_	_	_	_	_
103	performed	_	_	_	_	_	_	_	_
104	to	_	_	_	_	_	_	_	BeginSeg=Yes
105	assess	_	_	_	_	_	_	_	_
106	experience	_	_	_	_	_	_	_	_
107	and	_	_	_	_	_	_	_	_
108	opinions	_	_	_	_	_	_	_	_
109	on	_	_	_	_	_	_	_	_
110	the	_	_	_	_	_	_	_	_
111	condition	_	_	_	_	_	_	_	_
112	of	_	_	_	_	_	_	_	_
113	medical	_	_	_	_	_	_	_	_
114	care	_	_	_	_	_	_	_	_
115	in	_	_	_	_	_	_	_	_
116	terrorist	_	_	_	_	_	_	_	_
117	attacks	_	_	_	_	_	_	_	_
118	and	_	_	_	_	_	_	_	_
119	natural	_	_	_	_	_	_	_	_
120	disasters	_	_	_	_	_	_	_	_
121	,	_	_	_	_	_	_	_	_
122	the	_	_	_	_	_	_	_	_
123	ethical	_	_	_	_	_	_	_	_
124	challenges	_	_	_	_	_	_	_	_
125	of	_	_	_	_	_	_	_	_
126	disaster	_	_	_	_	_	_	_	_
127	medical	_	_	_	_	_	_	_	_
128	care	_	_	_	_	_	_	_	_
129	,	_	_	_	_	_	_	_	_
130	and	_	_	_	_	_	_	_	_
131	the	_	_	_	_	_	_	_	_
132	professional	_	_	_	_	_	_	_	_
133	responsibilities	_	_	_	_	_	_	_	_
134	and	_	_	_	_	_	_	_	_
135	responsiveness	_	_	_	_	_	_	_	_
136	in	_	_	_	_	_	_	_	_
137	disasters	_	_	_	_	_	_	_	_
138	.	_	_	_	_	_	_	_	_
139	CONCLUSIONS	_	_	_	_	_	_	_	BeginSeg=Yes
140	:	_	_	_	_	_	_	_	_
141	It	_	_	_	_	_	_	_	BeginSeg=Yes
142	is	_	_	_	_	_	_	_	_
143	necessary	_	_	_	_	_	_	_	_
144	to	_	_	_	_	_	_	_	_
145	develop	_	_	_	_	_	_	_	_
146	a	_	_	_	_	_	_	_	_
147	national	_	_	_	_	_	_	_	_
148	consensus	_	_	_	_	_	_	_	_
149	on	_	_	_	_	_	_	_	_
150	the	_	_	_	_	_	_	_	_
151	ethical	_	_	_	_	_	_	_	_
152	guidelines	_	_	_	_	_	_	_	_
153	for	_	_	_	_	_	_	_	_
154	physicians	_	_	_	_	_	_	_	_
155	who	_	_	_	_	_	_	_	BeginSeg=Yes
156	care	_	_	_	_	_	_	_	_
157	for	_	_	_	_	_	_	_	_
158	patients	_	_	_	_	_	_	_	_
159	,	_	_	_	_	_	_	_	_
160	victims	_	_	_	_	_	_	_	_
161	,	_	_	_	_	_	_	_	_
162	and	_	_	_	_	_	_	_	_
163	casualties	_	_	_	_	_	_	_	_
164	of	_	_	_	_	_	_	_	_
165	disasters	_	_	_	_	_	_	_	_
166	,	_	_	_	_	_	_	_	_
167	and	_	_	_	_	_	_	_	BeginSeg=Yes
168	to	_	_	_	_	_	_	_	_
169	formulate	_	_	_	_	_	_	_	_
170	a	_	_	_	_	_	_	_	_
171	virtuebased	_	_	_	_	_	_	_	_
172	,	_	_	_	_	_	_	_	_
173	yet	_	_	_	_	_	_	_	_
174	practical	_	_	_	_	_	_	_	_
175	,	_	_	_	_	_	_	_	_
176	ethical	_	_	_	_	_	_	_	_
177	approach	_	_	_	_	_	_	_	_
178	to	_	_	_	_	_	_	_	_
179	medical	_	_	_	_	_	_	_	_
180	care	_	_	_	_	_	_	_	_
181	under	_	_	_	_	_	_	_	_
182	such	_	_	_	_	_	_	_	_
183	extreme	_	_	_	_	_	_	_	_
184	conditions	_	_	_	_	_	_	_	_
185	.	_	_	_	_	_	_	_	_
186	An	_	_	_	_	_	_	_	BeginSeg=Yes
187	educational	_	_	_	_	_	_	_	_
188	curriculum	_	_	_	_	_	_	_	_
189	for	_	_	_	_	_	_	_	_
190	medical	_	_	_	_	_	_	_	_
191	students	_	_	_	_	_	_	_	_
192	,	_	_	_	_	_	_	_	_
193	residents	_	_	_	_	_	_	_	_
194	,	_	_	_	_	_	_	_	_
195	and	_	_	_	_	_	_	_	_
196	practicing	_	_	_	_	_	_	_	_
197	physicians	_	_	_	_	_	_	_	_
198	is	_	_	_	_	_	_	_	_
199	required	_	_	_	_	_	_	_	_
200	to	_	_	_	_	_	_	_	BeginSeg=Yes
201	best	_	_	_	_	_	_	_	_
202	prepare	_	_	_	_	_	_	_	_
203	all	_	_	_	_	_	_	_	_
204	physicians	_	_	_	_	_	_	_	_
205	who	_	_	_	_	_	_	_	BeginSeg=Yes
206	might	_	_	_	_	_	_	_	_
207	be	_	_	_	_	_	_	_	_
208	called	_	_	_	_	_	_	_	_
209	upon	_	_	_	_	_	_	_	_
210	,	_	_	_	_	_	_	_	_
211	in	_	_	_	_	_	_	_	_
212	the	_	_	_	_	_	_	_	_
213	future	_	_	_	_	_	_	_	_
214	,	_	_	_	_	_	_	_	_
215	to	_	_	_	_	_	_	_	BeginSeg=Yes
216	triage	_	_	_	_	_	_	_	_
217	patients	_	_	_	_	_	_	_	_
218	,	_	_	_	_	_	_	_	_
219	allocate	_	_	_	_	_	_	_	_
220	resources	_	_	_	_	_	_	_	_
221	,	_	_	_	_	_	_	_	_
222	and	_	_	_	_	_	_	_	_
223	make	_	_	_	_	_	_	_	_
224	difficult	_	_	_	_	_	_	_	_
225	decisions	_	_	_	_	_	_	_	_
226	about	_	_	_	_	_	_	_	_
227	treatment	_	_	_	_	_	_	_	_
228	priorities	_	_	_	_	_	_	_	_
229	and	_	_	_	_	_	_	_	_
230	comfort	_	_	_	_	_	_	_	_
231	care	_	_	_	_	_	_	_	_
232	.	_	_	_	_	_	_	_	_
233	It	_	_	_	_	_	_	_	BeginSeg=Yes
234	is	_	_	_	_	_	_	_	_
235	not	_	_	_	_	_	_	_	_
236	appropriate	_	_	_	_	_	_	_	_
237	to	_	_	_	_	_	_	_	_
238	address	_	_	_	_	_	_	_	_
239	these	_	_	_	_	_	_	_	_
240	questions	_	_	_	_	_	_	_	_
241	at	_	_	_	_	_	_	_	_
242	the	_	_	_	_	_	_	_	_
243	time	_	_	_	_	_	_	_	_
244	of	_	_	_	_	_	_	_	_
245	the	_	_	_	_	_	_	_	_
246	disaster	_	_	_	_	_	_	_	_
247	,	_	_	_	_	_	_	_	_
248	but	_	_	_	_	_	_	_	BeginSeg=Yes
249	rather	_	_	_	_	_	_	_	_
250	in	_	_	_	_	_	_	_	_
251	advance	_	_	_	_	_	_	_	_
252	,	_	_	_	_	_	_	_	_
253	as	_	_	_	_	_	_	_	_
254	part	_	_	_	_	_	_	_	_
255	of	_	_	_	_	_	_	_	_
256	the	_	_	_	_	_	_	_	_
257	ethics	_	_	_	_	_	_	_	_
258	education	_	_	_	_	_	_	_	_
259	of	_	_	_	_	_	_	_	_
260	the	_	_	_	_	_	_	_	_
261	medical	_	_	_	_	_	_	_	_
262	profession	_	_	_	_	_	_	_	_
263	.	_	_	_	_	_	_	_	_
264	Important	_	_	_	_	_	_	_	BeginSeg=Yes
265	issues	_	_	_	_	_	_	_	_
266	for	_	_	_	_	_	_	_	_
267	resolution	_	_	_	_	_	_	_	_
268	include	_	_	_	_	_	_	_	_
269	inpatient	_	_	_	_	_	_	_	_
270	and	_	_	_	_	_	_	_	_
271	casualty	_	_	_	_	_	_	_	_
272	triage	_	_	_	_	_	_	_	_
273	and	_	_	_	_	_	_	_	_
274	prioritization	_	_	_	_	_	_	_	_
275	,	_	_	_	_	_	_	_	_
276	medical	_	_	_	_	_	_	_	_
277	liability	_	_	_	_	_	_	_	_
278	,	_	_	_	_	_	_	_	_
279	altered	_	_	_	_	_	_	_	_
280	standards	_	_	_	_	_	_	_	_
281	of	_	_	_	_	_	_	_	_
282	care	_	_	_	_	_	_	_	_
283	,	_	_	_	_	_	_	_	_
284	justice	_	_	_	_	_	_	_	_
285	and	_	_	_	_	_	_	_	_
286	equity	_	_	_	_	_	_	_	_
287	,	_	_	_	_	_	_	_	_
288	informed	_	_	_	_	_	_	_	_
289	consent	_	_	_	_	_	_	_	_
290	and	_	_	_	_	_	_	_	_
291	patient	_	_	_	_	_	_	_	_
292	autonomy	_	_	_	_	_	_	_	_
293	,	_	_	_	_	_	_	_	_
294	expanding	_	_	_	_	_	_	_	_
295	scope	_	_	_	_	_	_	_	_
296	of	_	_	_	_	_	_	_	_
297	practice	_	_	_	_	_	_	_	_
298	in	_	_	_	_	_	_	_	_
299	disaster	_	_	_	_	_	_	_	_
300	medicine	_	_	_	_	_	_	_	_
301	,	_	_	_	_	_	_	_	_
302	and	_	_	_	_	_	_	_	_
303	the	_	_	_	_	_	_	_	_
304	moral	_	_	_	_	_	_	_	_
305	and	_	_	_	_	_	_	_	_
306	ethical	_	_	_	_	_	_	_	_
307	responsibilities	_	_	_	_	_	_	_	_
308	of	_	_	_	_	_	_	_	_
309	physicians	_	_	_	_	_	_	_	_
310	to	_	_	_	_	_	_	_	_
311	care	_	_	_	_	_	_	_	_
312	for	_	_	_	_	_	_	_	_
313	disaster	_	_	_	_	_	_	_	_
314	victims	_	_	_	_	_	_	_	_
315	.	_	_	_	_	_	_	_	_

# newdoc_id = d25529180f950874e0b4f62a976959d683a2ceaf
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2	N	_	_	_	_	_	_	_	_
3	-	_	_	_	_	_	_	_	_
4	terminal	_	_	_	_	_	_	_	_
5	domain	_	_	_	_	_	_	_	_
6	of	_	_	_	_	_	_	_	_
7	the	_	_	_	_	_	_	_	_
8	coronavirus	_	_	_	_	_	_	_	_
9	nucleocapsid	_	_	_	_	_	_	_	_
10	(	_	_	_	_	_	_	_	_
11	N	_	_	_	_	_	_	_	_
12	)	_	_	_	_	_	_	_	_
13	protein	_	_	_	_	_	_	_	_
14	adopts	_	_	_	_	_	_	_	_
15	a	_	_	_	_	_	_	_	_
16	fold	_	_	_	_	_	_	_	_
17	resembling	_	_	_	_	_	_	_	BeginSeg=Yes
18	a	_	_	_	_	_	_	_	_
19	right	_	_	_	_	_	_	_	_
20	hand	_	_	_	_	_	_	_	_
21	with	_	_	_	_	_	_	_	_
22	a	_	_	_	_	_	_	_	_
23	flexible	_	_	_	_	_	_	_	_
24	,	_	_	_	_	_	_	_	_
25	positively	_	_	_	_	_	_	_	_
26	charged	_	_	_	_	_	_	_	_
27	b	_	_	_	_	_	_	_	_
28	-	_	_	_	_	_	_	_	_
29	hairpin	_	_	_	_	_	_	_	_
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31	a	_	_	_	_	_	_	_	_
32	hydrophobic	_	_	_	_	_	_	_	_
33	palm	_	_	_	_	_	_	_	_
34	.	_	_	_	_	_	_	_	_
35	This	_	_	_	_	_	_	_	BeginSeg=Yes
36	domain	_	_	_	_	_	_	_	_
37	was	_	_	_	_	_	_	_	_
38	shown	_	_	_	_	_	_	_	_
39	to	_	_	_	_	_	_	_	_
40	interact	_	_	_	_	_	_	_	_
41	with	_	_	_	_	_	_	_	_
42	the	_	_	_	_	_	_	_	_
43	genomic	_	_	_	_	_	_	_	_
44	RNA	_	_	_	_	_	_	_	_
45	for	_	_	_	_	_	_	_	_
46	coronavirus	_	_	_	_	_	_	_	_
47	infectious	_	_	_	_	_	_	_	_
48	bronchitis	_	_	_	_	_	_	_	_
49	virus	_	_	_	_	_	_	_	_
50	(	_	_	_	_	_	_	_	_
51	IBV	_	_	_	_	_	_	_	_
52	)	_	_	_	_	_	_	_	_
53	and	_	_	_	_	_	_	_	_
54	severe	_	_	_	_	_	_	_	_
55	acute	_	_	_	_	_	_	_	_
56	respiratory	_	_	_	_	_	_	_	_
57	syndrome	_	_	_	_	_	_	_	_
58	coronavirus	_	_	_	_	_	_	_	_
59	(	_	_	_	_	_	_	_	_
60	SARS	_	_	_	_	_	_	_	_
61	-	_	_	_	_	_	_	_	_
62	CoV	_	_	_	_	_	_	_	_
63	)	_	_	_	_	_	_	_	_
64	.	_	_	_	_	_	_	_	_
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66	on	_	_	_	_	_	_	_	_
67	its	_	_	_	_	_	_	_	_
68	3D	_	_	_	_	_	_	_	_
69	structure	_	_	_	_	_	_	_	_
70	,	_	_	_	_	_	_	_	_
71	we	_	_	_	_	_	_	_	BeginSeg=Yes
72	used	_	_	_	_	_	_	_	_
73	site	_	_	_	_	_	_	_	_
74	-	_	_	_	_	_	_	_	_
75	directed	_	_	_	_	_	_	_	_
76	mutagenesis	_	_	_	_	_	_	_	_
77	to	_	_	_	_	_	_	_	BeginSeg=Yes
78	identify	_	_	_	_	_	_	_	_
79	residues	_	_	_	_	_	_	_	_
80	essential	_	_	_	_	_	_	_	BeginSeg=Yes
81	for	_	_	_	_	_	_	_	_
82	the	_	_	_	_	_	_	_	_
83	RNA	_	_	_	_	_	_	_	_
84	-	_	_	_	_	_	_	_	_
85	binding	_	_	_	_	_	_	_	_
86	activity	_	_	_	_	_	_	_	_
87	of	_	_	_	_	_	_	_	_
88	the	_	_	_	_	_	_	_	_
89	IBV	_	_	_	_	_	_	_	_
90	N	_	_	_	_	_	_	_	_
91	protein	_	_	_	_	_	_	_	_
92	and	_	_	_	_	_	_	_	_
93	viral	_	_	_	_	_	_	_	_
94	infectivity	_	_	_	_	_	_	_	_
95	.	_	_	_	_	_	_	_	_
96	Alanine	_	_	_	_	_	_	_	BeginSeg=Yes
97	substitution	_	_	_	_	_	_	_	_
98	of	_	_	_	_	_	_	_	_
99	either	_	_	_	_	_	_	_	_
100	Arg-76	_	_	_	_	_	_	_	_
101	or	_	_	_	_	_	_	_	_
102	Tyr-94	_	_	_	_	_	_	_	_
103	in	_	_	_	_	_	_	_	_
104	the	_	_	_	_	_	_	_	_
105	N	_	_	_	_	_	_	_	_
106	-	_	_	_	_	_	_	_	_
107	terminal	_	_	_	_	_	_	_	_
108	domain	_	_	_	_	_	_	_	_
109	of	_	_	_	_	_	_	_	_
110	IBV	_	_	_	_	_	_	_	_
111	N	_	_	_	_	_	_	_	_
112	protein	_	_	_	_	_	_	_	_
113	led	_	_	_	_	_	_	_	_
114	to	_	_	_	_	_	_	_	_
115	a	_	_	_	_	_	_	_	_
116	significant	_	_	_	_	_	_	_	_
117	decrease	_	_	_	_	_	_	_	_
118	in	_	_	_	_	_	_	_	_
119	its	_	_	_	_	_	_	_	_
120	RNA	_	_	_	_	_	_	_	_
121	-	_	_	_	_	_	_	_	_
122	binding	_	_	_	_	_	_	_	_
123	activity	_	_	_	_	_	_	_	_
124	and	_	_	_	_	_	_	_	_
125	a	_	_	_	_	_	_	_	_
126	total	_	_	_	_	_	_	_	_
127	loss	_	_	_	_	_	_	_	_
128	of	_	_	_	_	_	_	_	_
129	the	_	_	_	_	_	_	_	_
130	infectivity	_	_	_	_	_	_	_	_
131	of	_	_	_	_	_	_	_	_
132	the	_	_	_	_	_	_	_	_
133	viral	_	_	_	_	_	_	_	_
134	RNA	_	_	_	_	_	_	_	_
135	to	_	_	_	_	_	_	_	_
136	Vero	_	_	_	_	_	_	_	_
137	cells	_	_	_	_	_	_	_	_
138	.	_	_	_	_	_	_	_	_
139	In	_	_	_	_	_	_	_	BeginSeg=Yes
140	contrast	_	_	_	_	_	_	_	_
141	,	_	_	_	_	_	_	_	_
142	mutation	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	amino	_	_	_	_	_	_	_	_
145	acid	_	_	_	_	_	_	_	_
146	Gln-74	_	_	_	_	_	_	_	_
147	to	_	_	_	_	_	_	_	_
148	an	_	_	_	_	_	_	_	_
149	alanine	_	_	_	_	_	_	_	_
150	,	_	_	_	_	_	_	_	_
151	which	_	_	_	_	_	_	_	BeginSeg=Yes
152	does	_	_	_	_	_	_	_	_
153	not	_	_	_	_	_	_	_	_
154	affect	_	_	_	_	_	_	_	_
155	the	_	_	_	_	_	_	_	_
156	binding	_	_	_	_	_	_	_	_
157	activity	_	_	_	_	_	_	_	_
158	of	_	_	_	_	_	_	_	_
159	the	_	_	_	_	_	_	_	_
160	N	_	_	_	_	_	_	_	_
161	-	_	_	_	_	_	_	_	_
162	terminal	_	_	_	_	_	_	_	_
163	domain	_	_	_	_	_	_	_	_
164	,	_	_	_	_	_	_	_	_
165	showed	_	_	_	_	_	_	_	BeginSeg=Yes
166	minimal	_	_	_	_	_	_	_	_
167	,	_	_	_	_	_	_	_	_
168	if	_	_	_	_	_	_	_	_
169	any	_	_	_	_	_	_	_	_
170	,	_	_	_	_	_	_	_	_
171	detrimental	_	_	_	_	_	_	_	_
172	effect	_	_	_	_	_	_	_	_
173	on	_	_	_	_	_	_	_	_
174	the	_	_	_	_	_	_	_	_
175	infectivity	_	_	_	_	_	_	_	_
176	of	_	_	_	_	_	_	_	_
177	IBV	_	_	_	_	_	_	_	_
178	.	_	_	_	_	_	_	_	_
179	This	_	_	_	_	_	_	_	BeginSeg=Yes
180	study	_	_	_	_	_	_	_	_
181	thus	_	_	_	_	_	_	_	_
182	identifies	_	_	_	_	_	_	_	_
183	residues	_	_	_	_	_	_	_	_
184	critical	_	_	_	_	_	_	_	BeginSeg=Yes
185	for	_	_	_	_	_	_	_	_
186	RNA	_	_	_	_	_	_	_	_
187	binding	_	_	_	_	_	_	_	_
188	on	_	_	_	_	_	_	_	_
189	the	_	_	_	_	_	_	_	_
190	nucleocapsid	_	_	_	_	_	_	_	_
191	surface	_	_	_	_	_	_	_	_
192	,	_	_	_	_	_	_	_	_
193	and	_	_	_	_	_	_	_	BeginSeg=Yes
194	presents	_	_	_	_	_	_	_	_
195	biochemical	_	_	_	_	_	_	_	_
196	and	_	_	_	_	_	_	_	_
197	genetic	_	_	_	_	_	_	_	_
198	evidence	_	_	_	_	_	_	_	_
199	that	_	_	_	_	_	_	_	BeginSeg=Yes
200	directly	_	_	_	_	_	_	_	_
201	links	_	_	_	_	_	_	_	_
202	the	_	_	_	_	_	_	_	_
203	RNA	_	_	_	_	_	_	_	_
204	binding	_	_	_	_	_	_	_	_
205	capacity	_	_	_	_	_	_	_	_
206	of	_	_	_	_	_	_	_	_
207	the	_	_	_	_	_	_	_	_
208	coronavirus	_	_	_	_	_	_	_	_
209	N	_	_	_	_	_	_	_	_
210	protein	_	_	_	_	_	_	_	_
211	to	_	_	_	_	_	_	_	_
212	the	_	_	_	_	_	_	_	_
213	viral	_	_	_	_	_	_	_	_
214	infectivity	_	_	_	_	_	_	_	_
215	in	_	_	_	_	_	_	_	_
216	cultured	_	_	_	_	_	_	_	_
217	cells	_	_	_	_	_	_	_	_
218	.	_	_	_	_	_	_	_	_
219	This	_	_	_	_	_	_	_	BeginSeg=Yes
220	information	_	_	_	_	_	_	_	_
221	would	_	_	_	_	_	_	_	_
222	be	_	_	_	_	_	_	_	_
223	useful	_	_	_	_	_	_	_	_
224	in	_	_	_	_	_	_	_	_
225	development	_	_	_	_	_	_	_	_
226	of	_	_	_	_	_	_	_	_
227	preventive	_	_	_	_	_	_	_	_
228	and	_	_	_	_	_	_	_	_
229	treatment	_	_	_	_	_	_	_	_
230	approaches	_	_	_	_	_	_	_	_
231	against	_	_	_	_	_	_	_	_
232	coronavirus	_	_	_	_	_	_	_	_
233	infection	_	_	_	_	_	_	_	_
234	.	_	_	_	_	_	_	_	_

# newdoc_id = e28346ba72cc0451ddb4afe2179ae0f070b54aed
1	Acquired	_	_	_	_	_	_	_	BeginSeg=Yes
2	myasthenia	_	_	_	_	_	_	_	_
3	gravis	_	_	_	_	_	_	_	_
4	was	_	_	_	_	_	_	_	_
5	diagnosed	_	_	_	_	_	_	_	_
6	in	_	_	_	_	_	_	_	_
7	a	_	_	_	_	_	_	_	_
8	five	_	_	_	_	_	_	_	_
9	-	_	_	_	_	_	_	_	_
10	year	_	_	_	_	_	_	_	_
11	-	_	_	_	_	_	_	_	_
12	old	_	_	_	_	_	_	_	_
13	domestic	_	_	_	_	_	_	_	_
14	shorthair	_	_	_	_	_	_	_	_
15	,	_	_	_	_	_	_	_	_
16	neutered	_	_	_	_	_	_	_	_
17	,	_	_	_	_	_	_	_	_
18	female	_	_	_	_	_	_	_	_
19	cat	_	_	_	_	_	_	_	_
20	with	_	_	_	_	_	_	_	_
21	generalised	_	_	_	_	_	_	_	_
22	muscle	_	_	_	_	_	_	_	_
23	weakness	_	_	_	_	_	_	_	_
24	,	_	_	_	_	_	_	_	_
25	tremors	_	_	_	_	_	_	_	_
26	,	_	_	_	_	_	_	_	_
27	dysphagia	_	_	_	_	_	_	_	_
28	and	_	_	_	_	_	_	_	_
29	alterations	_	_	_	_	_	_	_	_
30	in	_	_	_	_	_	_	_	_
31	voice	_	_	_	_	_	_	_	_
32	.	_	_	_	_	_	_	_	_
33	Radiographs	_	_	_	_	_	_	_	BeginSeg=Yes
34	indicated	_	_	_	_	_	_	_	_
35	the	_	_	_	_	_	_	_	_
36	presence	_	_	_	_	_	_	_	_
37	of	_	_	_	_	_	_	_	_
38	a	_	_	_	_	_	_	_	_
39	mass	_	_	_	_	_	_	_	_
40	in	_	_	_	_	_	_	_	_
41	the	_	_	_	_	_	_	_	_
42	anterior	_	_	_	_	_	_	_	_
43	thorax	_	_	_	_	_	_	_	_
44	.	_	_	_	_	_	_	_	_
45	A	_	_	_	_	_	_	_	BeginSeg=Yes
46	response	_	_	_	_	_	_	_	_
47	to	_	_	_	_	_	_	_	_
48	edrophonium	_	_	_	_	_	_	_	_
49	chloride	_	_	_	_	_	_	_	_
50	,	_	_	_	_	_	_	_	_
51	and	_	_	_	_	_	_	_	_
52	raised	_	_	_	_	_	_	_	_
53	levels	_	_	_	_	_	_	_	_
54	of	_	_	_	_	_	_	_	_
55	anti	_	_	_	_	_	_	_	_
56	-	_	_	_	_	_	_	_	_
57	acetylcholine	_	_	_	_	_	_	_	_
58	receptor	_	_	_	_	_	_	_	_
59	antibodies	_	_	_	_	_	_	_	_
60	in	_	_	_	_	_	_	_	_
61	the	_	_	_	_	_	_	_	_
62	serum	_	_	_	_	_	_	_	_
63	,	_	_	_	_	_	_	_	_
64	confirmed	_	_	_	_	_	_	_	_
65	the	_	_	_	_	_	_	_	_
66	diagnosis	_	_	_	_	_	_	_	_
67	and	_	_	_	_	_	_	_	BeginSeg=Yes
68	indicated	_	_	_	_	_	_	_	_
69	an	_	_	_	_	_	_	_	_
70	immune	_	_	_	_	_	_	_	_
71	-	_	_	_	_	_	_	_	_
72	mediated	_	_	_	_	_	_	_	_
73	aetiology	_	_	_	_	_	_	_	_
74	.	_	_	_	_	_	_	_	_
75	Clinical	_	_	_	_	_	_	_	BeginSeg=Yes
76	remission	_	_	_	_	_	_	_	_
77	occurred	_	_	_	_	_	_	_	_
78	following	_	_	_	_	_	_	_	BeginSeg=Yes
79	thymectomy	_	_	_	_	_	_	_	_
80	and	_	_	_	_	_	_	_	_
81	the	_	_	_	_	_	_	_	_
82	use	_	_	_	_	_	_	_	_
83	of	_	_	_	_	_	_	_	_
84	immunosuppressive	_	_	_	_	_	_	_	_
85	corticosteroids	_	_	_	_	_	_	_	_
86	.	_	_	_	_	_	_	_	_
87	This	_	_	_	_	_	_	_	BeginSeg=Yes
88	is	_	_	_	_	_	_	_	_
89	the	_	_	_	_	_	_	_	_
90	first	_	_	_	_	_	_	_	_
91	fully	_	_	_	_	_	_	_	_
92	-	_	_	_	_	_	_	_	_
93	documented	_	_	_	_	_	_	_	_
94	case	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	acquired	_	_	_	_	_	_	_	_
97	feline	_	_	_	_	_	_	_	_
98	myasthenia	_	_	_	_	_	_	_	_
99	gravis	_	_	_	_	_	_	_	_
100	associated	_	_	_	_	_	_	_	BeginSeg=Yes
101	with	_	_	_	_	_	_	_	_
102	the	_	_	_	_	_	_	_	_
103	presence	_	_	_	_	_	_	_	_
104	of	_	_	_	_	_	_	_	_
105	a	_	_	_	_	_	_	_	_
106	thymic	_	_	_	_	_	_	_	_
107	abnormality	_	_	_	_	_	_	_	_
108	in	_	_	_	_	_	_	_	BeginSeg=Yes
109	the	_	_	_	_	_	_	_	_
110	United	_	_	_	_	_	_	_	_
111	Kingdom	_	_	_	_	_	_	_	_
112	.	_	_	_	_	_	_	_	_
113	The	_	_	_	_	_	_	_	BeginSeg=Yes
114	clinical	_	_	_	_	_	_	_	_
115	features	_	_	_	_	_	_	_	_
116	,	_	_	_	_	_	_	_	_
117	laboratory	_	_	_	_	_	_	_	_
118	findings	_	_	_	_	_	_	_	_
119	and	_	_	_	_	_	_	_	_
120	response	_	_	_	_	_	_	_	_
121	to	_	_	_	_	_	_	_	_
122	treatment	_	_	_	_	_	_	_	_
123	are	_	_	_	_	_	_	_	_
124	compared	_	_	_	_	_	_	_	_
125	with	_	_	_	_	_	_	_	_
126	those	_	_	_	_	_	_	_	_
127	reported	_	_	_	_	_	_	_	BeginSeg=Yes
128	previously	_	_	_	_	_	_	_	_
129	in	_	_	_	_	_	_	_	_
130	cats	_	_	_	_	_	_	_	_
131	and	_	_	_	_	_	_	_	_
132	other	_	_	_	_	_	_	_	_
133	species	_	_	_	_	_	_	_	_
134	.	_	_	_	_	_	_	_	_

# newdoc_id = e4c385d140cb5798b6fe90aabe8fefcc0dabfd99
1	Surface	_	_	_	_	_	_	_	BeginSeg=Yes
2	modified	_	_	_	_	_	_	_	_
3	bioactive	_	_	_	_	_	_	_	_
4	virus	_	_	_	_	_	_	_	_
5	-	_	_	_	_	_	_	_	_
6	mimicking	_	_	_	_	_	_	_	_
7	organic	_	_	_	_	_	_	_	_
8	nanovesicles	_	_	_	_	_	_	_	_
9	represent	_	_	_	_	_	_	_	_
10	themselves	_	_	_	_	_	_	_	_
11	as	_	_	_	_	_	_	_	_
12	complex	_	_	_	_	_	_	_	_
13	biomimetic	_	_	_	_	_	_	_	_
14	structures	_	_	_	_	_	_	_	_
15	that	_	_	_	_	_	_	_	BeginSeg=Yes
16	have	_	_	_	_	_	_	_	_
17	abilities	_	_	_	_	_	_	_	_
18	to	_	_	_	_	_	_	_	BeginSeg=Yes
19	dissect	_	_	_	_	_	_	_	_
20	the	_	_	_	_	_	_	_	_
21	functions	_	_	_	_	_	_	_	_
22	of	_	_	_	_	_	_	_	_
23	individual	_	_	_	_	_	_	_	_
24	entities	_	_	_	_	_	_	_	_
25	in	_	_	_	_	_	_	_	_
26	a	_	_	_	_	_	_	_	_
27	complex	_	_	_	_	_	_	_	_
28	biochemical	_	_	_	_	_	_	_	_
29	system	_	_	_	_	_	_	_	_
30	.	_	_	_	_	_	_	_	_
31	The	_	_	_	_	_	_	_	BeginSeg=Yes
32	customized	_	_	_	_	_	_	_	_
33	surface	_	_	_	_	_	_	_	_
34	of	_	_	_	_	_	_	_	_
35	nanovesicles	_	_	_	_	_	_	_	_
36	from	_	_	_	_	_	_	_	_
37	(	_	_	_	_	_	_	_	_
38	glyco)dendrimersomes	_	_	_	_	_	_	_	_
39	has	_	_	_	_	_	_	_	_
40	structural	_	_	_	_	_	_	_	_
41	modifications	_	_	_	_	_	_	_	_
42	that	_	_	_	_	_	_	_	BeginSeg=Yes
43	contribute	_	_	_	_	_	_	_	_
44	to	_	_	_	_	_	_	_	_
45	manifest	_	_	_	_	_	_	_	_
46	the	_	_	_	_	_	_	_	_
47	SARS	_	_	_	_	_	_	_	_
48	-	_	_	_	_	_	_	_	_
49	CoV-2	_	_	_	_	_	_	_	_
50	and	_	_	_	_	_	_	_	_
51	host	_	_	_	_	_	_	_	_
52	pathogenic	_	_	_	_	_	_	_	_
53	molecular	_	_	_	_	_	_	_	_
54	interactions	_	_	_	_	_	_	_	_
55	that	_	_	_	_	_	_	_	BeginSeg=Yes
56	help	_	_	_	_	_	_	_	_
57	the	_	_	_	_	_	_	_	_
58	virus	_	_	_	_	_	_	_	_
59	to	_	_	_	_	_	_	_	_
60	evade	_	_	_	_	_	_	_	_
61	the	_	_	_	_	_	_	_	_
62	human	_	_	_	_	_	_	_	_
63	immune	_	_	_	_	_	_	_	_
64	system	_	_	_	_	_	_	_	_
65	.	_	_	_	_	_	_	_	_
66	Nanovesicles	_	_	_	_	_	_	_	BeginSeg=Yes
67	also	_	_	_	_	_	_	_	_
68	have	_	_	_	_	_	_	_	_
69	a	_	_	_	_	_	_	_	_
70	potential	_	_	_	_	_	_	_	_
71	role	_	_	_	_	_	_	_	_
72	in	_	_	_	_	_	_	_	_
73	dynamic	_	_	_	_	_	_	_	_
74	biomedical	_	_	_	_	_	_	_	_
75	applications	_	_	_	_	_	_	_	_
76	such	_	_	_	_	_	_	_	BeginSeg=Yes
77	as	_	_	_	_	_	_	_	_
78	designing	_	_	_	_	_	_	_	_
79	galectin	_	_	_	_	_	_	_	_
80	targeting	_	_	_	_	_	_	_	_
81	drugs	_	_	_	_	_	_	_	_
82	,	_	_	_	_	_	_	_	_
83	evaluation	_	_	_	_	_	_	_	_
84	of	_	_	_	_	_	_	_	_
85	antibodies	_	_	_	_	_	_	_	_
86	to	_	_	_	_	_	_	_	BeginSeg=Yes
87	design	_	_	_	_	_	_	_	_
88	antiviral	_	_	_	_	_	_	_	_
89	therapeutics	_	_	_	_	_	_	_	_
90	or	_	_	_	_	_	_	_	_
91	vaccines	_	_	_	_	_	_	_	_
92	and	_	_	_	_	_	_	_	BeginSeg=Yes
93	targeted	_	_	_	_	_	_	_	_
94	delivery	_	_	_	_	_	_	_	_
95	of	_	_	_	_	_	_	_	_
96	drugs	_	_	_	_	_	_	_	_
97	.	_	_	_	_	_	_	_	_

# newdoc_id = e9dda9694a2e4c405b84595621b777223793d69a
1	Functional	_	_	_	_	_	_	_	BeginSeg=Yes
2	protein	_	_	_	_	_	_	_	_
3	microarrays	_	_	_	_	_	_	_	_
4	are	_	_	_	_	_	_	_	_
5	emerging	_	_	_	_	_	_	_	_
6	as	_	_	_	_	_	_	_	_
7	a	_	_	_	_	_	_	_	_
8	promising	_	_	_	_	_	_	_	_
9	new	_	_	_	_	_	_	_	_
10	tool	_	_	_	_	_	_	_	_
11	for	_	_	_	_	_	_	_	_
12	large	_	_	_	_	_	_	_	_
13	-	_	_	_	_	_	_	_	_
14	scale	_	_	_	_	_	_	_	_
15	and	_	_	_	_	_	_	_	_
16	highthroughput	_	_	_	_	_	_	_	_
17	studies	_	_	_	_	_	_	_	_
18	.	_	_	_	_	_	_	_	_
19	In	_	_	_	_	_	_	_	BeginSeg=Yes
20	this	_	_	_	_	_	_	_	_
21	article	_	_	_	_	_	_	_	_
22	,	_	_	_	_	_	_	_	_
23	we	_	_	_	_	_	_	_	_
24	will	_	_	_	_	_	_	_	_
25	review	_	_	_	_	_	_	_	_
26	their	_	_	_	_	_	_	_	_
27	applications	_	_	_	_	_	_	_	_
28	in	_	_	_	_	_	_	_	_
29	basic	_	_	_	_	_	_	_	_
30	proteomics	_	_	_	_	_	_	_	_
31	research	_	_	_	_	_	_	_	_
32	,	_	_	_	_	_	_	_	_
33	where	_	_	_	_	_	_	_	BeginSeg=Yes
34	various	_	_	_	_	_	_	_	_
35	types	_	_	_	_	_	_	_	_
36	of	_	_	_	_	_	_	_	_
37	assays	_	_	_	_	_	_	_	_
38	have	_	_	_	_	_	_	_	_
39	been	_	_	_	_	_	_	_	_
40	developed	_	_	_	_	_	_	_	_
41	to	_	_	_	_	_	_	_	BeginSeg=Yes
42	probe	_	_	_	_	_	_	_	_
43	binding	_	_	_	_	_	_	_	_
44	activities	_	_	_	_	_	_	_	_
45	to	_	_	_	_	_	_	_	_
46	other	_	_	_	_	_	_	_	_
47	biomolecules	_	_	_	_	_	_	_	_
48	,	_	_	_	_	_	_	_	_
49	such	_	_	_	_	_	_	_	BeginSeg=Yes
50	as	_	_	_	_	_	_	_	_
51	proteins	_	_	_	_	_	_	_	_
52	,	_	_	_	_	_	_	_	_
53	DNA	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	RNA	_	_	_	_	_	_	_	_
56	,	_	_	_	_	_	_	_	_
57	small	_	_	_	_	_	_	_	_
58	molecules	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	and	_	_	_	_	_	_	_	_
61	glycans	_	_	_	_	_	_	_	_
62	.	_	_	_	_	_	_	_	_
63	We	_	_	_	_	_	_	_	BeginSeg=Yes
64	will	_	_	_	_	_	_	_	_
65	also	_	_	_	_	_	_	_	_
66	report	_	_	_	_	_	_	_	_
67	recent	_	_	_	_	_	_	_	_
68	progress	_	_	_	_	_	_	_	_
69	of	_	_	_	_	_	_	_	BeginSeg=Yes
70	using	_	_	_	_	_	_	_	_
71	functional	_	_	_	_	_	_	_	_
72	protein	_	_	_	_	_	_	_	_
73	microarrays	_	_	_	_	_	_	_	_
74	in	_	_	_	_	_	_	_	BeginSeg=Yes
75	profiling	_	_	_	_	_	_	_	_
76	protein	_	_	_	_	_	_	_	_
77	posttranslational	_	_	_	_	_	_	_	_
78	modifications	_	_	_	_	_	_	_	_
79	,	_	_	_	_	_	_	_	_
80	including	_	_	_	_	_	_	_	BeginSeg=Yes
81	phosphorylation	_	_	_	_	_	_	_	_
82	,	_	_	_	_	_	_	_	_
83	ubiquitylation	_	_	_	_	_	_	_	_
84	,	_	_	_	_	_	_	_	_
85	acetylation	_	_	_	_	_	_	_	_
86	,	_	_	_	_	_	_	_	_
87	and	_	_	_	_	_	_	_	_
88	nitrosylation	_	_	_	_	_	_	_	_
89	.	_	_	_	_	_	_	_	_
90	Finally	_	_	_	_	_	_	_	BeginSeg=Yes
91	,	_	_	_	_	_	_	_	_
92	we	_	_	_	_	_	_	_	_
93	will	_	_	_	_	_	_	_	_
94	discuss	_	_	_	_	_	_	_	_
95	potential	_	_	_	_	_	_	_	_
96	of	_	_	_	_	_	_	_	_
97	functional	_	_	_	_	_	_	_	_
98	protein	_	_	_	_	_	_	_	_
99	microarrays	_	_	_	_	_	_	_	_
100	in	_	_	_	_	_	_	_	_
101	biomarker	_	_	_	_	_	_	_	_
102	identification	_	_	_	_	_	_	_	_
103	and	_	_	_	_	_	_	_	_
104	clinical	_	_	_	_	_	_	_	_
105	diagnostics	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	We	_	_	_	_	_	_	_	BeginSeg=Yes
108	strongly	_	_	_	_	_	_	_	_
109	believe	_	_	_	_	_	_	_	_
110	that	_	_	_	_	_	_	_	BeginSeg=Yes
111	functional	_	_	_	_	_	_	_	_
112	protein	_	_	_	_	_	_	_	_
113	microarrays	_	_	_	_	_	_	_	_
114	will	_	_	_	_	_	_	_	_
115	soon	_	_	_	_	_	_	_	_
116	become	_	_	_	_	_	_	_	_
117	an	_	_	_	_	_	_	_	_
118	indispensible	_	_	_	_	_	_	_	_
119	and	_	_	_	_	_	_	_	_
120	invaluable	_	_	_	_	_	_	_	_
121	tool	_	_	_	_	_	_	_	_
122	in	_	_	_	_	_	_	_	_
123	proteomics	_	_	_	_	_	_	_	_
124	research	_	_	_	_	_	_	_	_
125	and	_	_	_	_	_	_	_	_
126	systems	_	_	_	_	_	_	_	_
127	biology	_	_	_	_	_	_	_	_
128	.	_	_	_	_	_	_	_	_

# newdoc_id = eaccbbd4d93f295b6c22ae217f159c288b29deb6
1	Porcine	_	_	_	_	_	_	_	BeginSeg=Yes
2	reproductive	_	_	_	_	_	_	_	_
3	and	_	_	_	_	_	_	_	_
4	respiratory	_	_	_	_	_	_	_	_
5	syndrome	_	_	_	_	_	_	_	_
6	(	_	_	_	_	_	_	_	_
7	PRRS	_	_	_	_	_	_	_	_
8	)	_	_	_	_	_	_	_	_
9	has	_	_	_	_	_	_	_	_
10	been	_	_	_	_	_	_	_	_
11	one	_	_	_	_	_	_	_	_
12	of	_	_	_	_	_	_	_	_
13	the	_	_	_	_	_	_	_	_
14	most	_	_	_	_	_	_	_	_
15	economically	_	_	_	_	_	_	_	_
16	important	_	_	_	_	_	_	_	_
17	diseases	_	_	_	_	_	_	_	_
18	affecting	_	_	_	_	_	_	_	BeginSeg=Yes
19	swine	_	_	_	_	_	_	_	_
20	industry	_	_	_	_	_	_	_	_
21	worldwide	_	_	_	_	_	_	_	_
22	and	_	_	_	_	_	_	_	BeginSeg=Yes
23	causes	_	_	_	_	_	_	_	_
24	great	_	_	_	_	_	_	_	_
25	economic	_	_	_	_	_	_	_	_
26	losses	_	_	_	_	_	_	_	_
27	each	_	_	_	_	_	_	_	_
28	year	_	_	_	_	_	_	_	_
29	.	_	_	_	_	_	_	_	_
30	PRRS	_	_	_	_	_	_	_	BeginSeg=Yes
31	virus	_	_	_	_	_	_	_	_
32	(	_	_	_	_	_	_	_	_
33	PRRSV	_	_	_	_	_	_	_	_
34	)	_	_	_	_	_	_	_	_
35	replicates	_	_	_	_	_	_	_	_
36	mainly	_	_	_	_	_	_	_	_
37	in	_	_	_	_	_	_	_	_
38	porcine	_	_	_	_	_	_	_	_
39	alveolar	_	_	_	_	_	_	_	_
40	macrophages	_	_	_	_	_	_	_	_
41	(	_	_	_	_	_	_	_	_
42	PAMs	_	_	_	_	_	_	_	_
43	)	_	_	_	_	_	_	_	_
44	and	_	_	_	_	_	_	_	_
45	dendritic	_	_	_	_	_	_	_	_
46	cells	_	_	_	_	_	_	_	_
47	(	_	_	_	_	_	_	_	_
48	DCs	_	_	_	_	_	_	_	_
49	)	_	_	_	_	_	_	_	_
50	and	_	_	_	_	_	_	_	BeginSeg=Yes
51	develops	_	_	_	_	_	_	_	_
52	persistent	_	_	_	_	_	_	_	_
53	infections	_	_	_	_	_	_	_	_
54	,	_	_	_	_	_	_	_	_
55	antibody	_	_	_	_	_	_	_	_
56	-	_	_	_	_	_	_	_	_
57	dependent	_	_	_	_	_	_	_	_
58	enhancement	_	_	_	_	_	_	_	_
59	(	_	_	_	_	_	_	_	_
60	ADE	_	_	_	_	_	_	_	_
61	)	_	_	_	_	_	_	_	_
62	,	_	_	_	_	_	_	_	_
63	interstitial	_	_	_	_	_	_	_	_
64	pneumonia	_	_	_	_	_	_	_	_
65	and	_	_	_	_	_	_	_	_
66	immunosuppression	_	_	_	_	_	_	_	_
67	.	_	_	_	_	_	_	_	_
68	But	_	_	_	_	_	_	_	BeginSeg=Yes
69	the	_	_	_	_	_	_	_	_
70	molecular	_	_	_	_	_	_	_	_
71	mechanisms	_	_	_	_	_	_	_	_
72	of	_	_	_	_	_	_	_	_
73	PRRSV	_	_	_	_	_	_	_	_
74	infection	_	_	_	_	_	_	_	_
75	still	_	_	_	_	_	_	_	_
76	are	_	_	_	_	_	_	_	_
77	poorly	_	_	_	_	_	_	_	_
78	understood	_	_	_	_	_	_	_	_
79	.	_	_	_	_	_	_	_	_
80	Here	_	_	_	_	_	_	_	BeginSeg=Yes
81	we	_	_	_	_	_	_	_	_
82	report	_	_	_	_	_	_	_	_
83	on	_	_	_	_	_	_	_	_
84	the	_	_	_	_	_	_	_	_
85	first	_	_	_	_	_	_	_	_
86	genome	_	_	_	_	_	_	_	_
87	-	_	_	_	_	_	_	_	_
88	wide	_	_	_	_	_	_	_	_
89	host	_	_	_	_	_	_	_	_
90	transcriptional	_	_	_	_	_	_	_	_
91	responses	_	_	_	_	_	_	_	_
92	to	_	_	_	_	_	_	_	_
93	classical	_	_	_	_	_	_	_	_
94	North	_	_	_	_	_	_	_	_
95	American	_	_	_	_	_	_	_	_
96	type	_	_	_	_	_	_	_	_
97	PRRSV	_	_	_	_	_	_	_	_
98	(	_	_	_	_	_	_	_	_
99	N	_	_	_	_	_	_	_	_
100	-	_	_	_	_	_	_	_	_
101	PRRSV	_	_	_	_	_	_	_	_
102	)	_	_	_	_	_	_	_	_
103	strain	_	_	_	_	_	_	_	_
104	CH	_	_	_	_	_	_	_	_
105	1a	_	_	_	_	_	_	_	_
106	infection	_	_	_	_	_	_	_	_
107	using	_	_	_	_	_	_	_	BeginSeg=Yes
108	Solexa	_	_	_	_	_	_	_	_
109	/	_	_	_	_	_	_	_	_
110-111	Illumina's	_	_	_	_	_	_	_	_
110	Illumina	_	_	_	_	_	_	_	_
111	's	_	_	_	_	_	_	_	_
112	digital	_	_	_	_	_	_	_	_
113	gene	_	_	_	_	_	_	_	_
114	expression	_	_	_	_	_	_	_	_
115	(	_	_	_	_	_	_	_	_
116	DGE	_	_	_	_	_	_	_	_
117	)	_	_	_	_	_	_	_	_
118	system	_	_	_	_	_	_	_	_
119	,	_	_	_	_	_	_	_	_
120	a	_	_	_	_	_	_	_	_
121	tagbased	_	_	_	_	_	_	_	_
122	high	_	_	_	_	_	_	_	_
123	-	_	_	_	_	_	_	_	_
124	throughput	_	_	_	_	_	_	_	_
125	transcriptome	_	_	_	_	_	_	_	_
126	sequencing	_	_	_	_	_	_	_	_
127	method	_	_	_	_	_	_	_	_
128	,	_	_	_	_	_	_	_	_
129	and	_	_	_	_	_	_	_	BeginSeg=Yes
130	analyse	_	_	_	_	_	_	_	_
131	systematically	_	_	_	_	_	_	_	_
132	the	_	_	_	_	_	_	_	_
133	relationship	_	_	_	_	_	_	_	_
134	between	_	_	_	_	_	_	_	_
135	pulmonary	_	_	_	_	_	_	_	_
136	gene	_	_	_	_	_	_	_	_
137	expression	_	_	_	_	_	_	_	_
138	profiles	_	_	_	_	_	_	_	_
139	after	_	_	_	_	_	_	_	_
140	N	_	_	_	_	_	_	_	_
141	-	_	_	_	_	_	_	_	_
142	PRRSV	_	_	_	_	_	_	_	_
143	infection	_	_	_	_	_	_	_	_
144	and	_	_	_	_	_	_	_	_
145	infection	_	_	_	_	_	_	_	_
146	pathology	_	_	_	_	_	_	_	_
147	.	_	_	_	_	_	_	_	_
148	Our	_	_	_	_	_	_	_	BeginSeg=Yes
149	results	_	_	_	_	_	_	_	_
150	suggest	_	_	_	_	_	_	_	_
151	that	_	_	_	_	_	_	_	BeginSeg=Yes
152	N	_	_	_	_	_	_	_	_
153	-	_	_	_	_	_	_	_	_
154	PRRSV	_	_	_	_	_	_	_	_
155	appeared	_	_	_	_	_	_	_	_
156	to	_	_	_	_	_	_	_	_
157	utilize	_	_	_	_	_	_	_	_
158	multiple	_	_	_	_	_	_	_	_
159	strategies	_	_	_	_	_	_	_	_
160	for	_	_	_	_	_	_	_	_
161	its	_	_	_	_	_	_	_	_
162	replication	_	_	_	_	_	_	_	_
163	and	_	_	_	_	_	_	_	_
164	spread	_	_	_	_	_	_	_	_
165	in	_	_	_	_	_	_	_	_
166	infected	_	_	_	_	_	_	_	_
167	pigs	_	_	_	_	_	_	_	_
168	,	_	_	_	_	_	_	_	_
169	including	_	_	_	_	_	_	_	BeginSeg=Yes
170	subverting	_	_	_	_	_	_	_	_
171	host	_	_	_	_	_	_	_	_
172	innate	_	_	_	_	_	_	_	_
173	immune	_	_	_	_	_	_	_	_
174	response	_	_	_	_	_	_	_	_
175	,	_	_	_	_	_	_	_	_
176	inducing	_	_	_	_	_	_	_	BeginSeg=Yes
177	an	_	_	_	_	_	_	_	_
178	anti	_	_	_	_	_	_	_	_
179	-	_	_	_	_	_	_	_	_
180	apoptotic	_	_	_	_	_	_	_	_
181	and	_	_	_	_	_	_	_	_
182	anti	_	_	_	_	_	_	_	_
183	-	_	_	_	_	_	_	_	_
184	inflammatory	_	_	_	_	_	_	_	_
185	state	_	_	_	_	_	_	_	_
186	as	_	_	_	_	_	_	_	BeginSeg=Yes
187	well	_	_	_	_	_	_	_	_
188	as	_	_	_	_	_	_	_	_
189	developing	_	_	_	_	_	_	_	_
190	ADE	_	_	_	_	_	_	_	_
191	.	_	_	_	_	_	_	_	_
192	Upregulation	_	_	_	_	_	_	_	BeginSeg=Yes
193	expression	_	_	_	_	_	_	_	_
194	of	_	_	_	_	_	_	_	_
195	virus	_	_	_	_	_	_	_	_
196	-	_	_	_	_	_	_	_	_
197	induced	_	_	_	_	_	_	_	_
198	pro	_	_	_	_	_	_	_	_
199	-	_	_	_	_	_	_	_	_
200	inflammatory	_	_	_	_	_	_	_	_
201	cytokines	_	_	_	_	_	_	_	_
202	,	_	_	_	_	_	_	_	_
203	chemokines	_	_	_	_	_	_	_	_
204	,	_	_	_	_	_	_	_	_
205	adhesion	_	_	_	_	_	_	_	_
206	molecules	_	_	_	_	_	_	_	_
207	and	_	_	_	_	_	_	_	_
208	inflammatory	_	_	_	_	_	_	_	_
209	enzymes	_	_	_	_	_	_	_	_
210	and	_	_	_	_	_	_	_	_
211	inflammatory	_	_	_	_	_	_	_	_
212	cells	_	_	_	_	_	_	_	_
213	,	_	_	_	_	_	_	_	_
214	antibodies	_	_	_	_	_	_	_	_
215	,	_	_	_	_	_	_	_	_
216	complement	_	_	_	_	_	_	_	_
217	activation	_	_	_	_	_	_	_	_
218	were	_	_	_	_	_	_	_	_
219	likely	_	_	_	_	_	_	_	_
220	to	_	_	_	_	_	_	_	_
221	result	_	_	_	_	_	_	_	_
222	in	_	_	_	_	_	_	_	_
223	the	_	_	_	_	_	_	_	_
224	development	_	_	_	_	_	_	_	_
225	of	_	_	_	_	_	_	_	_
226	inflammatory	_	_	_	_	_	_	_	_
227	responses	_	_	_	_	_	_	_	_
228	during	_	_	_	_	_	_	_	_
229	N	_	_	_	_	_	_	_	_
230	-	_	_	_	_	_	_	_	_
231	PRRSV	_	_	_	_	_	_	_	_
232	infection	_	_	_	_	_	_	_	_
233	processes	_	_	_	_	_	_	_	_
234	.	_	_	_	_	_	_	_	_
235	N	_	_	_	_	_	_	_	BeginSeg=Yes
236	-	_	_	_	_	_	_	_	_
237	PRRSV	_	_	_	_	_	_	_	_
238	-	_	_	_	_	_	_	_	_
239	induced	_	_	_	_	_	_	_	_
240	immunosuppression	_	_	_	_	_	_	_	_
241	might	_	_	_	_	_	_	_	_
242	be	_	_	_	_	_	_	_	_
243	mediated	_	_	_	_	_	_	_	_
244	by	_	_	_	_	_	_	_	_
245	apoptosis	_	_	_	_	_	_	_	_
246	of	_	_	_	_	_	_	_	_
247	infected	_	_	_	_	_	_	_	_
248	cells	_	_	_	_	_	_	_	_
249	,	_	_	_	_	_	_	_	_
250	which	_	_	_	_	_	_	_	BeginSeg=Yes
251	caused	_	_	_	_	_	_	_	_
252	depletion	_	_	_	_	_	_	_	_
253	of	_	_	_	_	_	_	_	_
254	immune	_	_	_	_	_	_	_	_
255	cells	_	_	_	_	_	_	_	_
256	and	_	_	_	_	_	_	_	BeginSeg=Yes
257	induced	_	_	_	_	_	_	_	_
258	an	_	_	_	_	_	_	_	_
259	anti	_	_	_	_	_	_	_	_
260	-	_	_	_	_	_	_	_	_
261	inflammatory	_	_	_	_	_	_	_	_
262	cytokine	_	_	_	_	_	_	_	_
263	response	_	_	_	_	_	_	_	_
264	in	_	_	_	_	_	_	_	BeginSeg=Yes
265	which	_	_	_	_	_	_	_	_
266	they	_	_	_	_	_	_	_	_
267	were	_	_	_	_	_	_	_	_
268	unable	_	_	_	_	_	_	_	_
269	to	_	_	_	_	_	_	_	_
270	eradicate	_	_	_	_	_	_	_	_
271	the	_	_	_	_	_	_	_	_
272	primary	_	_	_	_	_	_	_	_
273	infection	_	_	_	_	_	_	_	_
274	.	_	_	_	_	_	_	_	_
275	Our	_	_	_	_	_	_	_	BeginSeg=Yes
276	systems	_	_	_	_	_	_	_	_
277	analysis	_	_	_	_	_	_	_	_
278	will	_	_	_	_	_	_	_	_
279	benefit	_	_	_	_	_	_	_	_
280	for	_	_	_	_	_	_	_	_
281	better	_	_	_	_	_	_	_	_
282	understanding	_	_	_	_	_	_	_	_
283	the	_	_	_	_	_	_	_	_
284	molecular	_	_	_	_	_	_	_	_
285	pathogenesis	_	_	_	_	_	_	_	_
286	of	_	_	_	_	_	_	_	_
287	N	_	_	_	_	_	_	_	_
288	-	_	_	_	_	_	_	_	_
289	PRRSV	_	_	_	_	_	_	_	_
290	infection	_	_	_	_	_	_	_	_
291	,	_	_	_	_	_	_	_	_
292	developing	_	_	_	_	_	_	_	_
293	novel	_	_	_	_	_	_	_	_
294	antiviral	_	_	_	_	_	_	_	_
295	therapies	_	_	_	_	_	_	_	_
296	and	_	_	_	_	_	_	_	_
297	identifying	_	_	_	_	_	_	_	_
298	genetic	_	_	_	_	_	_	_	_
299	components	_	_	_	_	_	_	_	_
300	for	_	_	_	_	_	_	_	_
301	swine	_	_	_	_	_	_	_	_
302	resistance	_	_	_	_	_	_	_	_
303	/	_	_	_	_	_	_	_	_
304	susceptibility	_	_	_	_	_	_	_	_
305	to	_	_	_	_	_	_	_	_
306	PRRS	_	_	_	_	_	_	_	_
307	.	_	_	_	_	_	_	_	_

# newdoc_id = ec79ce88059cfd9ffc56a62863ab0b2de34c4d1d
1	Background	_	_	_	_	_	_	_	BeginSeg=Yes
2	:	_	_	_	_	_	_	_	_
3	Public	_	_	_	_	_	_	_	BeginSeg=Yes
4	health	_	_	_	_	_	_	_	_
5	and	_	_	_	_	_	_	_	_
6	health	_	_	_	_	_	_	_	_
7	promotion	_	_	_	_	_	_	_	_
8	rely	_	_	_	_	_	_	_	_
9	on	_	_	_	_	_	_	_	_
10	many	_	_	_	_	_	_	_	_
11	different	_	_	_	_	_	_	_	_
12	interventions	_	_	_	_	_	_	_	_
13	,	_	_	_	_	_	_	_	_
14	which	_	_	_	_	_	_	_	BeginSeg=Yes
15	range	_	_	_	_	_	_	_	_
16	from	_	_	_	_	_	_	_	_
17	health	_	_	_	_	_	_	_	_
18	education	_	_	_	_	_	_	_	_
19	and	_	_	_	_	_	_	_	_
20	communication	_	_	_	_	_	_	_	_
21	,	_	_	_	_	_	_	_	_
22	through	_	_	_	_	_	_	_	_
23	community	_	_	_	_	_	_	_	_
24	mobilisation	_	_	_	_	_	_	_	_
25	and	_	_	_	_	_	_	_	_
26	changes	_	_	_	_	_	_	_	_
27	to	_	_	_	_	_	_	_	_
28	environmental	_	_	_	_	_	_	_	_
29	conditions	_	_	_	_	_	_	_	_
30	,	_	_	_	_	_	_	_	_
31	to	_	_	_	_	_	_	_	_
32	legal	_	_	_	_	_	_	_	_
33	and	_	_	_	_	_	_	_	_
34	fiscal	_	_	_	_	_	_	_	_
35	actions	_	_	_	_	_	_	_	_
36	.	_	_	_	_	_	_	_	_
37	The	_	_	_	_	_	_	_	BeginSeg=Yes
38	introduction	_	_	_	_	_	_	_	_
39	of	_	_	_	_	_	_	_	_
40	the	_	_	_	_	_	_	_	_
41	increased	_	_	_	_	_	_	_	_
42	tax	_	_	_	_	_	_	_	_
43	on	_	_	_	_	_	_	_	_
44	sugar	_	_	_	_	_	_	_	_
45	-	_	_	_	_	_	_	_	_
46	sweetened	_	_	_	_	_	_	_	_
47	beverages	_	_	_	_	_	_	_	_
48	(	_	_	_	_	_	_	_	_
49	SSB	_	_	_	_	_	_	_	_
50	)	_	_	_	_	_	_	_	_
51	,	_	_	_	_	_	_	_	_
52	popularly	_	_	_	_	_	_	_	BeginSeg=Yes
53	called	_	_	_	_	_	_	_	_
54	sugar	_	_	_	_	_	_	_	_
55	tax	_	_	_	_	_	_	_	_
56	(	_	_	_	_	_	_	_	_
57	ST	_	_	_	_	_	_	_	_
58	)	_	_	_	_	_	_	_	_
59	,	_	_	_	_	_	_	_	_
60	and	_	_	_	_	_	_	_	BeginSeg=Yes
61	a	_	_	_	_	_	_	_	_
62	mandatory	_	_	_	_	_	_	_	_
63	programme	_	_	_	_	_	_	_	_
64	of	_	_	_	_	_	_	_	_
65	vaccinations	_	_	_	_	_	_	_	_
66	are	_	_	_	_	_	_	_	_
67	the	_	_	_	_	_	_	_	_
68	strategies	_	_	_	_	_	_	_	_
69	inciting	_	_	_	_	_	_	_	BeginSeg=Yes
70	the	_	_	_	_	_	_	_	_
71	most	_	_	_	_	_	_	_	_
72	vivid	_	_	_	_	_	_	_	_
73	discussions	_	_	_	_	_	_	_	_
74	in	_	_	_	_	_	_	_	_
75	Polish	_	_	_	_	_	_	_	_
76	society	_	_	_	_	_	_	_	_
77	.	_	_	_	_	_	_	_	_
78	The	_	_	_	_	_	_	_	BeginSeg=Yes
79	study	_	_	_	_	_	_	_	_
80	was	_	_	_	_	_	_	_	_
81	intended	_	_	_	_	_	_	_	_
82	to	_	_	_	_	_	_	_	_
83	assess	_	_	_	_	_	_	_	_
84	the	_	_	_	_	_	_	_	_
85	determinants	_	_	_	_	_	_	_	_
86	of	_	_	_	_	_	_	_	_
87	the	_	_	_	_	_	_	_	_
88	attitudes	_	_	_	_	_	_	_	_
89	of	_	_	_	_	_	_	_	_
90	Polish	_	_	_	_	_	_	_	_
91	society	_	_	_	_	_	_	_	_
92	regarding	_	_	_	_	_	_	_	BeginSeg=Yes
93	the	_	_	_	_	_	_	_	_
94	ST	_	_	_	_	_	_	_	_
95	and	_	_	_	_	_	_	_	_
96	to	_	_	_	_	_	_	_	_
97	vaccinations	_	_	_	_	_	_	_	_
98	.	_	_	_	_	_	_	_	_
99	Methods	_	_	_	_	_	_	_	BeginSeg=Yes
100	:	_	_	_	_	_	_	_	_
101	For	_	_	_	_	_	_	_	BeginSeg=Yes
102	the	_	_	_	_	_	_	_	_
103	analysis	_	_	_	_	_	_	_	_
104	,	_	_	_	_	_	_	_	_
105	the	_	_	_	_	_	_	_	_
106	data	_	_	_	_	_	_	_	_
107	originating	_	_	_	_	_	_	_	BeginSeg=Yes
108	from	_	_	_	_	_	_	_	_
109	the	_	_	_	_	_	_	_	_
110	survey	_	_	_	_	_	_	_	_
111	of	_	_	_	_	_	_	_	_
112	a	_	_	_	_	_	_	_	_
113	representative	_	_	_	_	_	_	_	_
114	adult	_	_	_	_	_	_	_	_
115	sample	_	_	_	_	_	_	_	_
116	of	_	_	_	_	_	_	_	_
117	Polish	_	_	_	_	_	_	_	_
118	society	_	_	_	_	_	_	_	_
119	(	_	_	_	_	_	_	_	BeginSeg=Yes
120	n	_	_	_	_	_	_	_	_
121	=	_	_	_	_	_	_	_	_
122	1000	_	_	_	_	_	_	_	_
123	)	_	_	_	_	_	_	_	_
124	was	_	_	_	_	_	_	_	BeginSeg=Yes
125	used	_	_	_	_	_	_	_	_
126	.	_	_	_	_	_	_	_	_
127	The	_	_	_	_	_	_	_	BeginSeg=Yes
128	survey	_	_	_	_	_	_	_	_
129	was	_	_	_	_	_	_	_	_
130	based	_	_	_	_	_	_	_	_
131	on	_	_	_	_	_	_	_	_
132	computer	_	_	_	_	_	_	_	_
133	-	_	_	_	_	_	_	_	_
134	assisted	_	_	_	_	_	_	_	_
135	telephone	_	_	_	_	_	_	_	_
136	interviewing	_	_	_	_	_	_	_	_
137	(	_	_	_	_	_	_	_	_
138	CATI	_	_	_	_	_	_	_	_
139	)	_	_	_	_	_	_	_	_
140	.	_	_	_	_	_	_	_	_
141	The	_	_	_	_	_	_	_	BeginSeg=Yes
142	assessment	_	_	_	_	_	_	_	_
143	of	_	_	_	_	_	_	_	_
144	the	_	_	_	_	_	_	_	_
145	relationships	_	_	_	_	_	_	_	_
146	between	_	_	_	_	_	_	_	_
147	the	_	_	_	_	_	_	_	_
148	selected	_	_	_	_	_	_	_	_
149	variables	_	_	_	_	_	_	_	_
150	and	_	_	_	_	_	_	_	_
151	the	_	_	_	_	_	_	_	_
152	opinions	_	_	_	_	_	_	_	_
153	about	_	_	_	_	_	_	_	_
154	the	_	_	_	_	_	_	_	_
155	introduction	_	_	_	_	_	_	_	_
156	of	_	_	_	_	_	_	_	_
157	the	_	_	_	_	_	_	_	_
158	ST	_	_	_	_	_	_	_	_
159	and	_	_	_	_	_	_	_	_
160	the	_	_	_	_	_	_	_	_
161	safety	_	_	_	_	_	_	_	_
162	and	_	_	_	_	_	_	_	_
163	effectiveness	_	_	_	_	_	_	_	_
164	of	_	_	_	_	_	_	_	_
165	vaccinations	_	_	_	_	_	_	_	_
166	were	_	_	_	_	_	_	_	_
167	carried	_	_	_	_	_	_	_	_
168	out	_	_	_	_	_	_	_	_
169	using	_	_	_	_	_	_	_	BeginSeg=Yes
170	the	_	_	_	_	_	_	_	_
171	chi	_	_	_	_	_	_	_	_
172	2	_	_	_	_	_	_	_	_
173	test	_	_	_	_	_	_	_	_
174	and	_	_	_	_	_	_	_	_
175	univariate	_	_	_	_	_	_	_	_
176	logistic	_	_	_	_	_	_	_	_
177	regression	_	_	_	_	_	_	_	_
178	models	_	_	_	_	_	_	_	_
179	.	_	_	_	_	_	_	_	_
180	Results	_	_	_	_	_	_	_	BeginSeg=Yes
181	:	_	_	_	_	_	_	_	_
182	The	_	_	_	_	_	_	_	BeginSeg=Yes
183	acceptance	_	_	_	_	_	_	_	_
184	of	_	_	_	_	_	_	_	_
185	the	_	_	_	_	_	_	_	_
186	ST	_	_	_	_	_	_	_	_
187	and	_	_	_	_	_	_	_	_
188	vaccination	_	_	_	_	_	_	_	_
189	showed	_	_	_	_	_	_	_	_
190	a	_	_	_	_	_	_	_	_
191	significant	_	_	_	_	_	_	_	_
192	relationship	_	_	_	_	_	_	_	_
193	to	_	_	_	_	_	_	_	_
194	the	_	_	_	_	_	_	_	_
195	level	_	_	_	_	_	_	_	_
196	of	_	_	_	_	_	_	_	_
197	health	_	_	_	_	_	_	_	_
198	literacy	_	_	_	_	_	_	_	_
199	(	_	_	_	_	_	_	_	_
200	HL	_	_	_	_	_	_	_	_
201	)	_	_	_	_	_	_	_	_
202	but	_	_	_	_	_	_	_	_
203	not	_	_	_	_	_	_	_	_
204	to	_	_	_	_	_	_	_	_
205	eHealth	_	_	_	_	_	_	_	_
206	literacy	_	_	_	_	_	_	_	_
207	(	_	_	_	_	_	_	_	_
208	eHL	_	_	_	_	_	_	_	_
209	)	_	_	_	_	_	_	_	_
210	.	_	_	_	_	_	_	_	_
211	Respondents	_	_	_	_	_	_	_	BeginSeg=Yes
212	having	_	_	_	_	_	_	_	BeginSeg=Yes
213	a	_	_	_	_	_	_	_	_
214	higher	_	_	_	_	_	_	_	_
215	rather	_	_	_	_	_	_	_	_
216	than	_	_	_	_	_	_	_	_
217	lower	_	_	_	_	_	_	_	_
218	HL	_	_	_	_	_	_	_	_
219	;	_	_	_	_	_	_	_	_
220	older	_	_	_	_	_	_	_	_
221	rather	_	_	_	_	_	_	_	_
222	than	_	_	_	_	_	_	_	_
223	younger	_	_	_	_	_	_	_	_
224	;	_	_	_	_	_	_	_	_
225	married	_	_	_	_	_	_	_	_
226	rather	_	_	_	_	_	_	_	_
227	than	_	_	_	_	_	_	_	_
228	singles	_	_	_	_	_	_	_	_
229	;	_	_	_	_	_	_	_	_
230	retired	_	_	_	_	_	_	_	_
231	,	_	_	_	_	_	_	_	_
232	or	_	_	_	_	_	_	_	_
233	on	_	_	_	_	_	_	_	_
234	a	_	_	_	_	_	_	_	_
235	disability	_	_	_	_	_	_	_	_
236	pension	_	_	_	_	_	_	_	_
237	,	_	_	_	_	_	_	_	_
238	rather	_	_	_	_	_	_	_	_
239	than	_	_	_	_	_	_	_	_
240	vocationally	_	_	_	_	_	_	_	_
241	active	_	_	_	_	_	_	_	_
242	and	_	_	_	_	_	_	_	_
243	nonusers	_	_	_	_	_	_	_	_
244	of	_	_	_	_	_	_	_	_
245	the	_	_	_	_	_	_	_	_
246	Internet	_	_	_	_	_	_	_	_
247	rather	_	_	_	_	_	_	_	_
248	than	_	_	_	_	_	_	_	_
249	users	_	_	_	_	_	_	_	_
250	were	_	_	_	_	_	_	_	BeginSeg=Yes
251	more	_	_	_	_	_	_	_	_
252	likely	_	_	_	_	_	_	_	_
253	to	_	_	_	_	_	_	_	_
254	show	_	_	_	_	_	_	_	_
255	an	_	_	_	_	_	_	_	_
256	acceptance	_	_	_	_	_	_	_	_
257	for	_	_	_	_	_	_	_	_
258	both	_	_	_	_	_	_	_	_
259	interventions	_	_	_	_	_	_	_	_
260	.	_	_	_	_	_	_	_	_
261	Those	_	_	_	_	_	_	_	BeginSeg=Yes
262	more	_	_	_	_	_	_	_	BeginSeg=Yes
263	frequently	_	_	_	_	_	_	_	_
264	using	_	_	_	_	_	_	_	_
265	health	_	_	_	_	_	_	_	_
266	care	_	_	_	_	_	_	_	_
267	services	_	_	_	_	_	_	_	_
268	and	_	_	_	_	_	_	_	BeginSeg=Yes
269	those	_	_	_	_	_	_	_	_
270	with	_	_	_	_	_	_	_	_
271	chronic	_	_	_	_	_	_	_	_
272	diseases	_	_	_	_	_	_	_	_
273	showed	_	_	_	_	_	_	_	_
274	a	_	_	_	_	_	_	_	_
275	greater	_	_	_	_	_	_	_	_
276	belief	_	_	_	_	_	_	_	_
277	in	_	_	_	_	_	_	_	_
278	the	_	_	_	_	_	_	_	_
279	safety	_	_	_	_	_	_	_	_
280	and	_	_	_	_	_	_	_	_
281	effectiveness	_	_	_	_	_	_	_	_
282	of	_	_	_	_	_	_	_	_
283	vaccinations	_	_	_	_	_	_	_	_
284	.	_	_	_	_	_	_	_	_
285	Conclusions	_	_	_	_	_	_	_	BeginSeg=Yes
286	:	_	_	_	_	_	_	_	_
287	The	_	_	_	_	_	_	_	BeginSeg=Yes
288	relationship	_	_	_	_	_	_	_	_
289	between	_	_	_	_	_	_	_	_
290	the	_	_	_	_	_	_	_	_
291	opinions	_	_	_	_	_	_	_	_
292	of	_	_	_	_	_	_	_	_
293	the	_	_	_	_	_	_	_	_
294	two	_	_	_	_	_	_	_	_
295	public	_	_	_	_	_	_	_	_
296	health	_	_	_	_	_	_	_	_
297	interventions	_	_	_	_	_	_	_	_
298	analysed	_	_	_	_	_	_	_	_
299	and	_	_	_	_	_	_	_	_
300	the	_	_	_	_	_	_	_	_
301	sociodemographic	_	_	_	_	_	_	_	_
302	variables	_	_	_	_	_	_	_	_
303	demonstrated	_	_	_	_	_	_	_	_
304	similar	_	_	_	_	_	_	_	_
305	patterns	_	_	_	_	_	_	_	_
306	.	_	_	_	_	_	_	_	_
307	Interestingly	_	_	_	_	_	_	_	BeginSeg=Yes
308	,	_	_	_	_	_	_	_	_
309	the	_	_	_	_	_	_	_	_
310	opinions	_	_	_	_	_	_	_	_
311	were	_	_	_	_	_	_	_	_
312	associated	_	_	_	_	_	_	_	_
313	only	_	_	_	_	_	_	_	_
314	with	_	_	_	_	_	_	_	_
315	HL	_	_	_	_	_	_	_	_
316	and	_	_	_	_	_	_	_	_
317	not	_	_	_	_	_	_	_	_
318	with	_	_	_	_	_	_	_	_
319	eHL	_	_	_	_	_	_	_	_
320	and	_	_	_	_	_	_	_	BeginSeg=Yes
321	users	_	_	_	_	_	_	_	_
322	of	_	_	_	_	_	_	_	_
323	the	_	_	_	_	_	_	_	_
324	Internet	_	_	_	_	_	_	_	_
325	were	_	_	_	_	_	_	_	_
326	more	_	_	_	_	_	_	_	_
327	sceptical	_	_	_	_	_	_	_	_
328	about	_	_	_	_	_	_	_	_
329	the	_	_	_	_	_	_	_	_
330	interventions	_	_	_	_	_	_	_	_
331	.	_	_	_	_	_	_	_	_

# newdoc_id = ece140f2d510d370f594707b718066f7173a39e1
1	Since	_	_	_	_	_	_	_	BeginSeg=Yes
2	it	_	_	_	_	_	_	_	_
3	emerged	_	_	_	_	_	_	_	_
4	in	_	_	_	_	_	_	_	_
5	Brazil	_	_	_	_	_	_	_	_
6	in	_	_	_	_	_	_	_	_
7	May	_	_	_	_	_	_	_	_
8	2015	_	_	_	_	_	_	_	_
9	,	_	_	_	_	_	_	_	_
10	the	_	_	_	_	_	_	_	BeginSeg=Yes
11	mosquito	_	_	_	_	_	_	_	_
12	-	_	_	_	_	_	_	_	_
13	borne	_	_	_	_	_	_	_	_
14	Zika	_	_	_	_	_	_	_	_
15	virus	_	_	_	_	_	_	_	_
16	(	_	_	_	_	_	_	_	_
17	ZIKV	_	_	_	_	_	_	_	_
18	)	_	_	_	_	_	_	_	_
19	has	_	_	_	_	_	_	_	_
20	raised	_	_	_	_	_	_	_	_
21	global	_	_	_	_	_	_	_	_
22	concern	_	_	_	_	_	_	_	_
23	due	_	_	_	_	_	_	_	BeginSeg=Yes
24	to	_	_	_	_	_	_	_	_
25	its	_	_	_	_	_	_	_	_
26	association	_	_	_	_	_	_	_	_
27	with	_	_	_	_	_	_	_	_
28	a	_	_	_	_	_	_	_	_
29	significant	_	_	_	_	_	_	_	_
30	rise	_	_	_	_	_	_	_	_
31	in	_	_	_	_	_	_	_	_
32	the	_	_	_	_	_	_	_	_
33	number	_	_	_	_	_	_	_	_
34	of	_	_	_	_	_	_	_	_
35	infants	_	_	_	_	_	_	_	_
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37	with	_	_	_	_	_	_	_	_
38	microcephaly	_	_	_	_	_	_	_	_
39	and	_	_	_	_	_	_	_	_
40	neurological	_	_	_	_	_	_	_	_
41	disorders	_	_	_	_	_	_	_	_
42	such	_	_	_	_	_	_	_	BeginSeg=Yes
43	as	_	_	_	_	_	_	_	_
44	Guillain	_	_	_	_	_	_	_	_
45	-	_	_	_	_	_	_	_	_
46	Barré	_	_	_	_	_	_	_	_
47	syndrome	_	_	_	_	_	_	_	_
48	We	_	_	_	_	_	_	_	BeginSeg=Yes
49	developed	_	_	_	_	_	_	_	_
50	prototype	_	_	_	_	_	_	_	_
51	subunit	_	_	_	_	_	_	_	_
52	and	_	_	_	_	_	_	_	_
53	adenoviral	_	_	_	_	_	_	_	_
54	-	_	_	_	_	_	_	_	_
55	based	_	_	_	_	_	_	_	_
56	Zika	_	_	_	_	_	_	_	_
57	vaccines	_	_	_	_	_	_	_	_
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59	the	_	_	_	_	_	_	_	_
60	extracellular	_	_	_	_	_	_	_	_
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62	of	_	_	_	_	_	_	_	_
63	the	_	_	_	_	_	_	_	_
64	ZIKV	_	_	_	_	_	_	_	_
65	envelope	_	_	_	_	_	_	_	_
66	gene	_	_	_	_	_	_	_	_
67	(	_	_	_	_	_	_	_	_
68	E	_	_	_	_	_	_	_	_
69	)	_	_	_	_	_	_	_	_
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71	to	_	_	_	_	_	_	_	_
72	the	_	_	_	_	_	_	_	_
73	T4	_	_	_	_	_	_	_	_
74	fibritin	_	_	_	_	_	_	_	_
75	foldon	_	_	_	_	_	_	_	_
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77	domain	_	_	_	_	_	_	_	_
78	(	_	_	_	_	_	_	_	_
79	Efl	_	_	_	_	_	_	_	_
80	)	_	_	_	_	_	_	_	_
81	.	_	_	_	_	_	_	_	_
82	The	_	_	_	_	_	_	_	BeginSeg=Yes
83	subunit	_	_	_	_	_	_	_	_
84	vaccine	_	_	_	_	_	_	_	_
85	was	_	_	_	_	_	_	_	_
86	delivered	_	_	_	_	_	_	_	_
87	intradermally	_	_	_	_	_	_	_	_
88	through	_	_	_	_	_	_	_	_
89	carboxymethyl	_	_	_	_	_	_	_	_
90	cellulose	_	_	_	_	_	_	_	_
91	microneedle	_	_	_	_	_	_	_	_
92	array	_	_	_	_	_	_	_	_
93	(	_	_	_	_	_	_	_	_
94	MNA	_	_	_	_	_	_	_	_
95	)	_	_	_	_	_	_	_	_
96	.	_	_	_	_	_	_	_	_
97	The	_	_	_	_	_	_	_	BeginSeg=Yes
98	immunogenicity	_	_	_	_	_	_	_	_
99	of	_	_	_	_	_	_	_	_
100	these	_	_	_	_	_	_	_	_
101	two	_	_	_	_	_	_	_	_
102	vaccines	_	_	_	_	_	_	_	_
103	,	_	_	_	_	_	_	_	_
104	named	_	_	_	_	_	_	_	BeginSeg=Yes
105	Ad5	_	_	_	_	_	_	_	_
106	.	_	_	_	_	_	_	_	_
107	ZIKV	_	_	_	_	_	_	_	_
108	-	_	_	_	_	_	_	_	_
109	Efl	_	_	_	_	_	_	_	_
110	and	_	_	_	_	_	_	_	_
111	ZIKV	_	_	_	_	_	_	_	_
112	-	_	_	_	_	_	_	_	_
113	rEfl	_	_	_	_	_	_	_	_
114	,	_	_	_	_	_	_	_	_
115	was	_	_	_	_	_	_	_	BeginSeg=Yes
116	tested	_	_	_	_	_	_	_	_
117	in	_	_	_	_	_	_	_	_
118	C57BL/6	_	_	_	_	_	_	_	_
119	mice	_	_	_	_	_	_	_	_
120	.	_	_	_	_	_	_	_	_
121	Prime	_	_	_	_	_	_	_	BeginSeg=Yes
122	/	_	_	_	_	_	_	_	_
123	boost	_	_	_	_	_	_	_	_
124	immunization	_	_	_	_	_	_	_	_
125	regimen	_	_	_	_	_	_	_	_
126	was	_	_	_	_	_	_	_	_
127	associated	_	_	_	_	_	_	_	_
128	with	_	_	_	_	_	_	_	_
129	induction	_	_	_	_	_	_	_	_
130	of	_	_	_	_	_	_	_	_
131	a	_	_	_	_	_	_	_	_
132	ZIKV	_	_	_	_	_	_	_	_
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134	specific	_	_	_	_	_	_	_	_
135	antibody	_	_	_	_	_	_	_	_
136	response	_	_	_	_	_	_	_	_
137	,	_	_	_	_	_	_	_	_
138	which	_	_	_	_	_	_	_	BeginSeg=Yes
139	provided	_	_	_	_	_	_	_	_
140	neutralizing	_	_	_	_	_	_	_	_
141	immunity	_	_	_	_	_	_	_	_
142	.	_	_	_	_	_	_	_	_
143	Moreover	_	_	_	_	_	_	_	BeginSeg=Yes
144	,	_	_	_	_	_	_	_	_
145	protection	_	_	_	_	_	_	_	_
146	was	_	_	_	_	_	_	_	_
147	evaluated	_	_	_	_	_	_	_	_
148	in	_	_	_	_	_	_	_	_
149	seven	_	_	_	_	_	_	_	_
150	-	_	_	_	_	_	_	_	_
151	day	_	_	_	_	_	_	_	_
152	-	_	_	_	_	_	_	_	_
153	old	_	_	_	_	_	_	_	_
154	pups	_	_	_	_	_	_	_	_
155	after	_	_	_	_	_	_	_	_
156	virulent	_	_	_	_	_	_	_	_
157	ZIKV	_	_	_	_	_	_	_	_
158	intraperitoneal	_	_	_	_	_	_	_	_
159	challenge	_	_	_	_	_	_	_	_
160	.	_	_	_	_	_	_	_	_
161	Pups	_	_	_	_	_	_	_	BeginSeg=Yes
162	born	_	_	_	_	_	_	_	BeginSeg=Yes
163	to	_	_	_	_	_	_	_	_
164	mice	_	_	_	_	_	_	_	_
165	immunized	_	_	_	_	_	_	_	BeginSeg=Yes
166	with	_	_	_	_	_	_	_	_
167	Ad5	_	_	_	_	_	_	_	_
168	.	_	_	_	_	_	_	_	_
169	ZIKV	_	_	_	_	_	_	_	_
170	-	_	_	_	_	_	_	_	_
171	Efl	_	_	_	_	_	_	_	_
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173	all	_	_	_	_	_	_	_	_
174	protected	_	_	_	_	_	_	_	_
175	against	_	_	_	_	_	_	_	_
176	lethal	_	_	_	_	_	_	_	_
177	challenge	_	_	_	_	_	_	_	_
178	infection	_	_	_	_	_	_	_	_
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180	weight	_	_	_	_	_	_	_	_
181	loss	_	_	_	_	_	_	_	_
182	or	_	_	_	_	_	_	_	_
183	neurological	_	_	_	_	_	_	_	_
184	signs	_	_	_	_	_	_	_	_
185	,	_	_	_	_	_	_	_	_
186	while	_	_	_	_	_	_	_	BeginSeg=Yes
187	pups	_	_	_	_	_	_	_	_
188	born	_	_	_	_	_	_	_	BeginSeg=Yes
189	to	_	_	_	_	_	_	_	_
190	dams	_	_	_	_	_	_	_	_
191	immunized	_	_	_	_	_	_	_	BeginSeg=Yes
192	with	_	_	_	_	_	_	_	_
193	MNA	_	_	_	_	_	_	_	_
194	-	_	_	_	_	_	_	_	_
195	ZIKV	_	_	_	_	_	_	_	_
196	-	_	_	_	_	_	_	_	_
197	rEfl	_	_	_	_	_	_	_	_
198	were	_	_	_	_	_	_	_	BeginSeg=Yes
199	partially	_	_	_	_	_	_	_	_
200	protected	_	_	_	_	_	_	_	_
201	(	_	_	_	_	_	_	_	BeginSeg=Yes
202	50	_	_	_	_	_	_	_	_
203	%	_	_	_	_	_	_	_	_
204	)	_	_	_	_	_	_	_	_
205	.	_	_	_	_	_	_	_	_
206	No	_	_	_	_	_	_	_	BeginSeg=Yes
207	protection	_	_	_	_	_	_	_	_
208	was	_	_	_	_	_	_	_	_
209	seen	_	_	_	_	_	_	_	_
210	in	_	_	_	_	_	_	_	_
211	pups	_	_	_	_	_	_	_	_
212	born	_	_	_	_	_	_	_	BeginSeg=Yes
213	to	_	_	_	_	_	_	_	_
214	phosphate	_	_	_	_	_	_	_	_
215	buffered	_	_	_	_	_	_	_	_
216	saline	_	_	_	_	_	_	_	_
217	-	_	_	_	_	_	_	_	_
218	immunized	_	_	_	_	_	_	_	_
219	mice	_	_	_	_	_	_	_	_
220	.	_	_	_	_	_	_	_	_
221	This	_	_	_	_	_	_	_	BeginSeg=Yes
222	study	_	_	_	_	_	_	_	_
223	illustrates	_	_	_	_	_	_	_	_
224	the	_	_	_	_	_	_	_	_
225	preliminary	_	_	_	_	_	_	_	_
226	efficacy	_	_	_	_	_	_	_	_
227	of	_	_	_	_	_	_	_	_
228	the	_	_	_	_	_	_	_	_
229	E	_	_	_	_	_	_	_	_
230	ZIKV	_	_	_	_	_	_	_	_
231	antigen	_	_	_	_	_	_	_	_
232	vaccination	_	_	_	_	_	_	_	_
233	in	_	_	_	_	_	_	_	BeginSeg=Yes
234	controlling	_	_	_	_	_	_	_	_
235	ZIKV	_	_	_	_	_	_	_	_
236	infectivity	_	_	_	_	_	_	_	_
237	,	_	_	_	_	_	_	_	_
238	providing	_	_	_	_	_	_	_	BeginSeg=Yes
239	a	_	_	_	_	_	_	_	_
240	promising	_	_	_	_	_	_	_	_
241	candidate	_	_	_	_	_	_	_	_
242	vaccine	_	_	_	_	_	_	_	_
243	and	_	_	_	_	_	_	_	_
244	antigen	_	_	_	_	_	_	_	_
245	format	_	_	_	_	_	_	_	_
246	for	_	_	_	_	_	_	_	_
247	the	_	_	_	_	_	_	_	_
248	prevention	_	_	_	_	_	_	_	_
249	of	_	_	_	_	_	_	_	_
250	Zika	_	_	_	_	_	_	_	_
251	virus	_	_	_	_	_	_	_	_
252	disease	_	_	_	_	_	_	_	_
253	.	_	_	_	_	_	_	_	_

# newdoc_id = edfc9c542b75092b7000be09fd4496c4122c28d7
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2	equipping	_	_	_	_	_	_	_	_
3	a	_	_	_	_	_	_	_	_
4	previously	_	_	_	_	_	_	_	_
5	reported	_	_	_	_	_	_	_	_
6	dynamic	_	_	_	_	_	_	_	_
7	causal	_	_	_	_	_	_	_	_
8	model	_	_	_	_	_	_	_	_
9	of	_	_	_	_	_	_	_	_
10	COVID-19	_	_	_	_	_	_	_	_
11	with	_	_	_	_	_	_	_	_
12	an	_	_	_	_	_	_	_	_
13	isolation	_	_	_	_	_	_	_	_
14	state	_	_	_	_	_	_	_	_
15	,	_	_	_	_	_	_	_	_
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17	modelled	_	_	_	_	_	_	_	_
18	the	_	_	_	_	_	_	_	_
19	effects	_	_	_	_	_	_	_	_
20	of	_	_	_	_	_	_	_	_
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22	-	_	_	_	_	_	_	_	_
23	isolation	_	_	_	_	_	_	_	_
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25	on	_	_	_	_	_	_	_	_
26	tracking	_	_	_	_	_	_	_	_
27	and	_	_	_	_	_	_	_	_
28	tracing	_	_	_	_	_	_	_	_
29	.	_	_	_	_	_	_	_	_
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31	,	_	_	_	_	_	_	_	_
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35	quarantine	_	_	_	_	_	_	_	_
36	or	_	_	_	_	_	_	_	_
37	isolation	_	_	_	_	_	_	_	_
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50	asymptomatic	_	_	_	_	_	_	_	_
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52	and	_	_	_	_	_	_	_	_
53	only	_	_	_	_	_	_	_	_
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59	.	_	_	_	_	_	_	_	_
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61	recovered	_	_	_	_	_	_	_	_
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63	posteriori	_	_	_	_	_	_	_	_
64	estimates	_	_	_	_	_	_	_	_
65	of	_	_	_	_	_	_	_	_
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67	model	_	_	_	_	_	_	_	_
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71	series	_	_	_	_	_	_	_	_
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73	new	_	_	_	_	_	_	_	_
74	cases	_	_	_	_	_	_	_	_
75	,	_	_	_	_	_	_	_	_
76	daily	_	_	_	_	_	_	_	_
77	deaths	_	_	_	_	_	_	_	_
78	,	_	_	_	_	_	_	_	_
79	and	_	_	_	_	_	_	_	_
80	tests	_	_	_	_	_	_	_	_
81	for	_	_	_	_	_	_	_	_
82	the	_	_	_	_	_	_	_	_
83	UK	_	_	_	_	_	_	_	_
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86	parameters	_	_	_	_	_	_	_	_
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88	used	_	_	_	_	_	_	_	_
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90	simulate	_	_	_	_	_	_	_	_
91	the	_	_	_	_	_	_	_	_
92	trajectory	_	_	_	_	_	_	_	_
93	of	_	_	_	_	_	_	_	_
94	the	_	_	_	_	_	_	_	_
95	outbreak	_	_	_	_	_	_	_	_
96	in	_	_	_	_	_	_	_	_
97	the	_	_	_	_	_	_	_	_
98	UK	_	_	_	_	_	_	_	_
99	over	_	_	_	_	_	_	_	_
100	an	_	_	_	_	_	_	_	_
101	18month	_	_	_	_	_	_	_	_
102	period	_	_	_	_	_	_	_	_
103	.	_	_	_	_	_	_	_	_
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105	clear	_	_	_	_	_	_	_	_
106	-	_	_	_	_	_	_	_	_
107	cut	_	_	_	_	_	_	_	_
108	conclusions	_	_	_	_	_	_	_	_
109	emerged	_	_	_	_	_	_	_	_
110	from	_	_	_	_	_	_	_	_
111	these	_	_	_	_	_	_	_	_
112	simulations	_	_	_	_	_	_	_	_
113	.	_	_	_	_	_	_	_	_
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115	example	_	_	_	_	_	_	_	_
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118	plausible	_	_	_	_	_	_	_	_
119	(	_	_	_	_	_	_	_	_
120	graded	_	_	_	_	_	_	_	_
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123	of	_	_	_	_	_	_	_	_
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125	distancing	_	_	_	_	_	_	_	_
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127	a	_	_	_	_	_	_	_	_
128	rebound	_	_	_	_	_	_	_	_
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61	rubiginosus	_	_	_	_	_	_	_	_
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65	pneumonia	_	_	_	_	_	_	_	_
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69	a	_	_	_	_	_	_	_	_
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117	fastidiousness	_	_	_	_	_	_	_	_
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119	antibiotic	_	_	_	_	_	_	_	_
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