FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: The adverse effect is manifested only if there is an exposure of sufficient level. Inter-laboratory reproducibility A measure of the extent to which different qualified laboratories, using the same protocol and testing the same test substances, can produce qualitatively and quantitatively similar results.
French: Elle constitue une mesure de performance de la méthode d’essai et l’un des aspects de sa pertinence.
German: Relevanz Dieser Begriff bezieht sich auf das Verhältnis zwischen dem Test und der betreffenden Wirkung und auf die Frage, ob er aussagekräftig und nützlich für einen bestimmten Zweck ist.
English: Outlier An outlier is an observation that is markedly different from other values in a random sample from a population. Performance standards (PS) Standards, based on a validated test method, that provide a basis for evaluating the comparability of a proposed test method that is functionally and mechanistically similar.
German: Validierte Prüfmethode Eine Prüfmethode, für die Validierungsstudien durchgeführt wurden, um die Relevanz (einschließlich Genauigkeit) und Zuverlässigkeit für einen bestimmten Verwendungszweck zu bestimmen. Es ist zu beachten, dass die Leistungsfähigkeit einer validierten Prüfmethode im Hinblick auf Genauigkeit und Zuverlässigkeit unter Umständen nicht den Anforderungen eines vorgeschlagenen Verwendungszwecks genügt (14). “
English: A wide range of chemicals has been tested in the validation underlying this TM and the empirical database of the validation study amounted to 58 chemicals in total (16) (18) (23). This is applicable to solids, liquids, semi-solids and waxes.
German: Die empirische Datenbasis der Validierungsstudie umfasste insgesamt 58 chemische Stoffe (16) (18) (23), einschließlich Feststoffen, Flüssigkeiten, halbfesten Stoffe und Wachsen.
English: The test chemical is applied topically to a three-dimensional RhE model, comprised of non-transformed human-derived epidermal keratinocytes, which have been cultured to form a multilayered, highly differentiated model of the human epidermis. It consists of organised basal, spinous and granular layers, and a multilayered stratum corneum containing intercellular lamellar lipid layers representing main lipid classes analogous to those found in vivo.
German: Die Prüfsubstanz wird oberflächlich auf ein RhE-Modell aufgetragen, bestehend aus nicht veränderten humanen epidermalen Keratinozyten, die zu einem mehrschichtigen, ausdifferenzierten Modell humaner Epidermis kultiviert wurden, das aus geordneten Basal-, Stachel- und Körnerzellschichten und einer mehrlagigen Hornschicht (stratum corneum) besteht, die interzelluläre lamellare Fettschichten enthält, deren dominierende Lipidklassen dem in vivo gefundenen Lipidmuster entsprechen.
English: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
German: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE).
Spanish: EC-ECVAM (CEVMA de la Comisión Europea) (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (EHR)?
Portuguese: CE-ECVAM (2009). Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE).
Finnish: EC-ECVAM (2009). Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
Greek: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)? Διατίθεται στον ιστότοπο:
Slovak: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
Slovenian: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
Estonian: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
Latvian: EC-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
Maltese: KE-ECVAM (2009), Performance Standards for in vitro skin irritation test methods based on Reconstructed human Epidermis (RhE)?
English: The testing laboratory should consider all available information on the test substance prior to conducting the study. Such information will include the identity and chemical structure of the test substance; its physicochemical properties; the results of any other in vitro or in vivo toxicity tests on the test substance; and toxicological data on structurally related chemicals.
French: Avant de procéder à l’essai, le laboratoire rassemble toutes les informations disponibles sur la substance d’essai, à savoir son identité et sa structure chimiques, ses propriétés physico-chimiques, les résultats de tous les autres essais de toxicité in vitro et in vivo, et les données toxicologiques sur des analogues de structure.
Italian: Prima di effettuare lo studio, il laboratorio che esegue il test deve consultare tutte le informazioni disponibili sulla sostanza di prova, tra cui l’identità e la struttura chimica, le proprietà chimiche-fisiche, i risultati di eventuali altri test di tossicità in vitro o in vivo eseguiti sulla sostanza e i dati tossicologici su sostanze strutturalmente affini.
Portuguese: Antes de efetuar o estudo, o laboratório deve examinar todas as informações disponíveis sobre a substância em causa, nomeadamente a identificação e a estrutura química, as propriedades físico-químicas, os resultados de quaisquer outros ensaios in vitro ou in vivo de toxicidade da substância e dados toxicológicos sobre produtos químicos com estrutura semelhante.
Greek: Πριν από τη διεξαγωγή της μελέτης, το εργαστήριο δοκιμών θα πρέπει να εξετάζει όλα τα διαθέσιμα στοιχεία σχετικά με την ελεγχόμενη ουσία, μεταξύ των οποίων την ταυτότητα και τη χημική δομή της, τις φυσικές και χημικές ιδιότητές της, τα αποτελέσματα τυχόν άλλων δοκιμών τοξικότητας της ουσίας, in vitro ή in vivo, και τα τοξικολογικά δεδομένα που αφορούν χημικά προϊόντα ανάλογης δομής.
English: Alternatively, inject 250 μL sterile PBS containing 2 μCi (7,4 × 104 Bq) of 125I-iododeoxyuridine and 10–5M fluorodeoxyuridine into all mice via the tail vein. Five hours (5 h) later, humanely kill the animals.
Greek: Εναλλακτικά, χορηγούνται σε όλους τους ποντικούς, με ένεση μέσω της ουραίας φλέβας, 250 μL PBS που περιέχει 2 μCi (7,4 × 104 Bq) 125I-ιωδοδεσοξυουριδίνης και φθοροδεσοξυουριδίνη σε συγκέντρωση 10-5 Μ. Μετά από πέντε ώρες, τα ζώα θανατώνονται με ευθανασία.
English: , The local lymph node assay and skin sensitisation: a cut-down screen to reduce animal requirements?
Portuguese: The local lymph node assay and skin sensitisation: a cut-down screen to reduce animal requirements?
Finnish: The local lymph node assay and skin sensitisation: a cut-down screen to reduce animal requirements?
Greek: , The local lymph node assay and skin sensitisation:
English: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report.
Portuguese: ICCVAM (2009). The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report. The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products.
Finnish: ICCVAM (2009). The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report. The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products.
Greek: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report. The Reduced Murine Local Lymph Node Assay:
Slovak: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report.
Slovenian: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report.
Estonian: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report.
Latvian: ICCVAM (2009), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report.
English: The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products, NIH Publication Number 09-6439, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Portuguese: NIH Publication Number 09-6439. Research Triangle Park, NC.
Swedish: The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products, NIH Publication No 09–6439, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Finnish: NIH-julkaisunumero 09-6439. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Greek: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products, NIH Publication Number 09-6439, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Lithuanian: The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products, NIH Publication Number 09–6439, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
English: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
French: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Portuguese: ICCVAM (2009). Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Finnish: ICCVAM (2009). Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Greek: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Slovak: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Slovenian: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Estonian: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
Latvian: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
English: The MTT assay is a validated quantitative method which should be used to measure cell viability under this TM. It is compatible with use in a three-dimensional tissue construct.
Portuguese: Para medir a viabilidade celular no âmbito do presente método, deve utilizar-se o método quantitativo validado do MTT, que é compatível com a arquitetura tridimensional dos tecidos.
Greek: Η δοκιμασία MTT αποτελεί επικυρωμένη ποσοτική μέθοδο η οποία πρέπει να χρησιμοποιείται για τη μέτρηση της κυτταρικής βιωσιμότητας στο πλαίσιο της παρούσας μεθόδου δοκιμών και είναι συμβατή με τη χρήση σε τρισδιάστατο ιστικό μόρφωμα.
English: Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. OJ L 353, 31.12.2008, p. 1.
French: Règlement (CE) no 1272/2008 du Parlement européen et du Conseil du 16 décembre 2008 relatif à la classification, à l’étiquetage et à l’emballage des substances et des mélanges, modifiant et abrogeant les directives 67/548/CEE et 1999/45/CE et modifiant le règlement (CE) no 1907/2006, JO L 353 du 31.12.2008, p. 1.
Italian: Regolamento (CE) n. 1272/2008 del Parlamento europeo e del Consiglio, del 16 dicembre 2008, relativo alla classificazione, all’etichettatura e all’imballaggio delle sostanze e delle miscele che modifica e abroga le direttive 67/548/CEE e 1999/45/CE e che reca modifica al regolamento (CE) n. 1907/2006, GU L 353 del 31.12.2008, pag. 1.
Portuguese: Regulamento (CE) n.o 1272/2008 do Parlamento Europeu e do Conselho, de 16 de dezembro de 2008, relativo à classificação, rotulagem e embalagem de substâncias e misturas, que altera e revoga as Diretivas 67/548/CEE e 1999/45/CE, e altera o Regulamento (CE) n.o 1907/2006, JO L 353 de 31.12.2008, p. 1.
Swedish: Europaparlamentets och rådets förordning (EG) nr 1272/2008 av den 16 december 2008 om klassificering, märkning och förpackning av ämnen och blandningar, ändring och upphävande av direktiven 67/548/EEG och 1999/45/EG samt ändring av förordning (EG) nr 1907/2006 (EUT L 353, 31.12.2008, s. 1).
Greek: Κανονισμός (ΕΚ) αριθ. 1272/2008 του Ευρωπαϊκού Κοινοβουλίου και του Συμβουλίου, της 16ης Δεκεμβρίου 2008, για την ταξινόμηση, την επισήμανση και τη συσκευασία των ουσιών και των μειγμάτων, την τροποποίηση και την κατάργηση των οδηγιών 67/548/ΕΟΚ και 1999/45/ΕΚ και την τροποποίηση του κανονισμού (ΕΚ) αριθ. 1907/2006 (ΕΕ L 353 της 31.12.2008, σ. 1).
Slovak: Nariadenie Európskeho parlamentu a Rady (ES) č. 1272/2008 zo 16. decembra 2008 o klasifikácii, označovaní a balení látok a zmesí, o zmene, doplnení a zrušení smerníc 67/548/EHS a 1999/45/ES a o zmene a doplnení nariadenia (ES) č. 1907/2006 (Ú. v. EÚ L 353, 31.12.2008, s. 1).
Hungarian: Az Európai Parlament és a Tanács 1272/2008/EK rendelete (2008. december 16.) az anyagok és keverékek osztályozásáról, címkézéséről és csomagolásáról, a 67/548/EGK és az 1999/45/EK irányelv módosításáról és hatályon kívül helyezéséről, valamint az 1907/2006/EK rendelet módosításáról, HL L 353., 2008.12.31., 1. o.
Romanian: Regulamentul (CE) nr. 1272/2008 al Parlamentului European și al Consiliului din 16 decembrie 2008 privind clasificarea, etichetarea și ambalarea substanțelor și a amestecurilor, de modificare și de abrogare a Directivelor 67/548/CEE și 1999/45/CE, precum și de modificare a Regulamentului (CE) nr. 1907/2006, JO L 353, 31.12.2008, p. 1.
English: Cat. 2
French: sans catégorie
Portuguese: Categoria 2
Greek: Κατηγορία 2
Hungarian: kat.
Estonian: kat.
Latvian: kat.
Lithuanian: 2 kat.
English: Substitute or additional chemicals can be included if their activity is known and if they induce micronuclei by the same mechanisms of action, and if they are shown to be relevant to the chemicals that will be tested using the MNvit procedure. Justification could include a validation study employing a broad variety of substances or focused on a narrower spectrum based on the chemical class of the test substance or the mechanism of damage being studied.
Greek: Μπορούν να συμπεριλαμβάνονται υποκατάστατα αυτών ή συμπληρωματικές χημικές ουσίες, εάν η δραστικότητά τους είναι γνωστή, εάν επάγουν μικροπυρήνες με τους ίδιους μηχανισμούς δράσης και εάν είναι αποδεδειγμένα συναφείς με τις χημικές ουσίες που θα υποβάλλονται σε δοκιμή με τη διαδικασία MNvit Η σχετική αιτιολόγηση μπορεί να περιλαμβάνει μελέτη επικύρωσης στην οποία χρησιμοποιήθηκε ευρύ φάσμα ουσιών ή η οποία επικεντρώθηκε σε στενότερο φάσμα, με βάση τη χημική τάξη της ελεγχόμενης ουσίας ή τον μελετώμενο μηχανισμό πρόκλησης βλάβης.
English: The test report should include at least the following information, if relevant to the conduct of the study: Test chemical:
Italian: La relazione sul saggio deve contenere perlomeno le seguenti informazioni, se pertinenti per l’esecuzione dello studio:
Greek: Η έκθεση δοκιμής πρέπει να περιλαμβάνει τουλάχιστον τα ακόλουθα στοιχεία, εφόσον αυτά έχουν σημασία για τη διεξαγωγή της μελέτης:
English: UNEP (2001), Stockholm Convention on Persistent Organic Pollutants, United Nations Environment Programme (UNEP).
French: PNUE (2001), Convention de Stockholm sur les polluants organiques persistants, Programme des Nations unies pour l’environnement (ONUE).
Spanish: PNUMA (2001), Convenio de Estocolmo sobre Contaminantes Orgánicos Persistentes, Programa de las Naciones Unidas para el Medio Ambiente (PNUMA).
Portuguese: PNUA (2001). Convenção de Estocolmo sobre Poluentes Orgânicos Persistentes.
Finnish: UNEP (2001). Pysyviä orgaanisia yhdisteitä koskeva Tukholman yleissopimus.
Greek: UNEP (2001), σύμβαση της Στοκχόλμης για τους έμμονους οργανικούς ρύπους, Πρόγραμμα των Ηνωμένων Εθνών για το Περιβάλλον (UNEP).
Slovak: UNEP (2001), Štokholmský dohovor o perzistentných organických látkach, Program OSN pre životné prostredie (UNEP).
Polish: UNEP (2001 r.), Konwencja Sztokholmska w sprawie trwałych zanieczyszczeń organicznych, Program Narodów Zjednoczonych ds. Ochrony Środowiska (UNEP).
Slovenian: UNEP (2001), Stockholm Convention on Persistent Organic Pollutants, United Nations Environment Programme (UNEP).
Estonian: UNEP (2001), püsivate orgaaniliste saasteainete Stockholmi konventsioon, ÜRO keskkonnaprogramm (UNEP).
Latvian: UNEP (2001), Stockholm Convention on Persistent Organic Pollutants, United Nations Environment Programme (UNEP).
Lithuanian: UNEP (2001), Stokholmo konvencija dėl patvariųjų organinių teršalų, Jungtinių Tautų aplinkos programa (UNEP).
English: , CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids, In: Tice, R.R., Costa, D.L. and Schaich, K.M.
French: , CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids.
Portuguese: CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids.
Greek: , CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids, In:
Slovenian: , CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids, v: Tice, R.R., Costa, D.L. and Schaich, K.M.
Maltese: , CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids, In: Tice, R.R., Costa, D.L. u Schaich, K.M.
English: The processing of lymph nodes from individual mice allows for the assessment of inter-animal variability and a statistical comparison of the difference between test substance and VC group measurements (see paragraph 33). In addition, evaluating the possibility of reducing the number of mice in the PC group is only feasible when individual animal data are collected (22).
Greek: Η επεξεργασία λεμφαδένων μεμονωμένων ποντικών επιτρέπει την εκτίμηση της μεταβλητότητας μεταξύ των ζώων και τη στατιστική ανάλυση της διαφοράς μεταξύ των μετρήσεων της ελεγχόμενης ουσίας και των μετρήσεων της ομάδας VC (βλέπε παράγραφο 33) Επιπλέον, η αξιολόγηση της δυνατότητας μείωσης του αριθμού ποντικών της ομάδας θετικού μάρτυρα είναι εφικτή μόνο εφόσον συλλέγονται δεδομένα για μεμονωμένα ζώα (22).
English: NIH Publication No: 99-4494.
French: Research Triangle Park, N.C.
Swedish: NIH Publication No: 99–4494.
Finnish: NIH-julkaisunumero 99-4494.
Greek: Research Triangle Park, N.C.
Slovak: NIH Publication No 99-4494.
Lithuanian: NIH Publication No: 99–4494.
English: Research Triangle Park, N.C.
Greek: Διατίθεται στον ιστότοπο:
English: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
French: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Portuguese: ICCVAM (2009). Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Finnish: ICCVAM (2009). Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Greek: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay:
Slovak: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Slovenian: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Estonian: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
Latvian: ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
English: Research Triangle Park, NC: National Institute of Environmental Health Sciences.
Portuguese: Research Triangle Park, NC. National Institute of Environmental Health Sciences.
Greek: a test method for assessing the allergic contact dermatitis potential of chemicals and products. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
English: The processing of lymph nodes from individual mice allows for the assessment of inter-animal variability and a statistical comparison of the difference between test substance and VC group measurements (see paragraph 33). In addition, evaluating the possibility of reducing the number of mice in the PC group is only feasible when individual animal data are collected (17).
Greek: Η επεξεργασία λεμφαδένων μεμονωμένων ποντικών επιτρέπει την εκτίμηση της μεταβλητότητας μεταξύ των ζώων και τη στατιστική ανάλυση της διαφοράς μεταξύ των μετρήσεων της ελεγχόμενης ουσίας και των μετρήσεων της ομάδας VC (βλέπε παράγραφο 33) Επιπλέον, η αξιολόγηση της δυνατότητας μείωσης του αριθμού ποντικών της ομάδας θετικού μάρτυρα είναι εφικτή μόνο εφόσον συλλέγονται δεδομένα για μεμονωμένα ζώα (17).
English: In each case, the target volume of the LNC suspension should be adjusted to a determined optimised volume (approximately 15 mL). The optimised volume is based on achieving a mean absorbance of the NC group within 0,1-0,2.
Greek: Σε κάθε περίπτωση, ο στοχευόμενος όγκος του εναιωρήματος λεμφοκυττάρων πρέπει να ρυθμίζεται σε βελτιστοποιημένο όγκο (περίπου 15 mL), ο οποίος προσδιορίζεται με γνώμονα την επίτευξη μέσης τιμής απορρόφησης 0,1-0,2 στην ομάδα αρνητικού μάρτυρα.