FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT). Food Chem.
French: Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. et Wendel, A. (2008), Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT), Food Chem.
Slovak: Kreiling, R., Hollnagel, H. M., Hareng, L., Eigler, L., Lee, M. S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT).
Lithuanian: Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT).
English: Basketter, D., Ball, N., Cagen, S., Carrilo, J.C., Certa, H., Eigler, D., Garcia, C., Esch, H., Graham, C., Haux, C., Kreiling, R. and Mehling, A. (2009), Application of a weight of evidence approach to assessing discordant sensitisation datasets: implications for REACH. Reg. Toxicol.
French: Basketter, D., Ball, N., Cagen, S., Carrilo, J.C., Certa, H., Eigler, D., Garcia, C., Esch, H., Graham, C., Haux, C., Kreiling, R. et Mehling, A. (2009), Application of a weight of evidence approach to assessing discordant sensitisation datasets: implications for REACH, Reg.
English: ILAR (1996), Institute of Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals. 7th ed. Washington, DC: National Academies Press.
French: ILAR (1996), Institute of Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals, 7th ed. Washington, DC: National Academies Press.
English: ICCVAM (2009), Recommended Performance Standards: Murine Local Lymph Node Assay. NIH Publication Number 09-7357.
French: ICCVAM (2009), Recommended Performance Standards: Murine Local Lymph Node Assay, NIH Publication Number 09-7357, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
English: Research Triangle Park, NC: National Institute of Environmental Health Sciences. Available at: [http://iccvam.niehs.nih.gov/docs/immunotox_docs/llna-ps/LLNAPerfStds.pdf]
French: Disponible à l’adresse suivante:[http://iccvam.niehs.nih.gov/docs/immunotox_docs/llna-ps/LLNAPerfStds.pdf]
English: , The murine local lymph node assay: regulatory and potency considerations under REACH. Toxicol., 238, 71-89.
French: , The murine local lymph node assay: regulatory and potency considerations under REACH, Toxicol., 238, 71-89.
English: , The local lymph node assay: developments and applications. Toxicol., 93, 13-31.
French: , The local lymph node assay: developments and applications, Toxicol., 93, 13-31.
English: , Use of an enhanced local lymph node assay to correctly classify irritants and false positive substances. Toxicologist, 96, 235.
French: , Use of an enhanced local lymph node assay to correctly classify irritants and false positive substances, Toxicologist, 96 (S-1), 235.
English: ICCVAM (2009), Nonradioactive Murine Local Lymph Node Assay: Flow Cytometry Test Method Protocol (LLNA: BrdU-FC) Revised Draft Background Review Document. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
French: ICCVAM (2009), Nonradioactive Murine Local Lymph Node Assay: Flow Cytometry Test Method Protocol (LLNA: BrdU-FC) Revised Draft Background Review Document, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
English: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice. Drug Chem.
French: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice, Drug Chem.
Lithuanian: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice.
English: , An integrated model for the differentiation of chemical-induced allergic and irritant skin reactions. Toxicol.
French: , An integrated model for the differentiation of chemical-induced allergic and irritant skin reactions, Toxicol.
English: , A combined murine local lymph node and irritancy assay to predict sensitisation and irritancy potential of chemicals. Toxicol.
French: , A combined murine local lymph node and irritancy assay to predict sensitisation and irritancy potential of chemicals, Toxicol.
English: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods. Drug.
French: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods, Drug.
Lithuanian: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods.
English: , A European inter- laboratory validation of alternative endpoints of the murine local lymph node assay: first round. Toxicol., 212, 60-68.
French: , A European inter- laboratory validation of alternative endpoints of the murine local lymph node assay: first round, Toxicol., 212, 60-68.
English: Patterson, R.M., Noga, E. and Germolec D. (2007), Lack of evidence for contact sensitisation by Pfiesteria extract. Environ.
French: Patterson, R.M., Noga, E. et Germolec D. (2007), Lack of evidence for contact sensitisation by Pfiesteria extract, Environ.
English: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
French: ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
English: , Assessment of the skin sensitisation potential of topical medicaments using the local lymph node assay: An interlaboratory exercise. J. Toxicol.
French: , Assessment of the skin sensitisation potential of topical medicaments using the local lymph node assay: An interlaboratory exercise, J. Toxicol.
English: Accuracy The closeness of agreement between test method results and accepted reference values. It is a measure of test method performance and one aspect of relevance.
French: Assurance qualité procédé de gestion dans lequel le respect des normes d’essai, des obligations du laboratoire et des procédures d’enregistrement des données, ainsi que la précision du transfert des données, sont évalués par des personnes indépendantes de celles qui réalisent les essais.
English: The term is often used interchangeably with “concordance” to mean the proportion of correct outcomes of a test method (33). Benchmark substance A sensitising or non-sensitising substance used as a standard for comparison to a test substance. A benchmark substance should have the following properties: (i) a consistent and reliable source(s); (ii) structural and functional similarity to the class of substances being tested; (iii) known physical/chemical characteristics; (iv) supporting data on known effects; and (v) known potency in the range of the desired response.
French: Faux négatif substance d’essai identifiée à tort comme négative ou inactive à l’issue de l’essai, alors qu’elle est en fait positive ou active (33).
English: For solids, the epidermis surface should be moistened with deionised or distilled water before application, to improve contact between the test chemical and the epidermis surface. Whenever possible, solids should be tested as a fine powder.
Hungarian: Szilárd anyagok alkalmazása előtt az epidermisz felületét ionmentesített vagy desztillált vízzel be kell nedvesíteni, hogy jobb legyen az érintkezés a vizsgált vegyi anyag és az epidermisz felszíne között.
English: The original Test Method (TM) for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLNA; OECD Test Guideline 429; Chapter B.42 of this Annex) was adopted previously (1). The details of the validation of the LLNA and a review of the associated work have been published (2) (3) (4) (5) (6) (7) (8) (9) (10) (11).
Italian: Il metodo di prova (TM) originale per la determinazione dell’irritazione cutanea nel topo, denominato Local Lymph Node Assay (LLNA; OCSE Test Guideline 429; capitolo B.42 del presente allegato) era stato precedentemente adottato (1) e sono state pubblicate informazioni dettagliate sulla validazione dell’LLNA nonché una revisione delle attività a questa associate (2) (3) (4) (5) (6) (7) (8) (9) (10) (11).
Maltese: Il-Metodu ta’ Ttestjar oriġinali (TM) għad-determinazzjoni tas-sensitizzazzjoni tal-ġilda fil-ġurdien, l-Analiżi tan-Nodula tal-Limfa Lokali (LLNA; Linja Gwida ta’ Ttestjar 429 tal-OECD; il-Kapitolu B.42 ta’ dan l-Anness) ġie adottat qabel (1) Id-dettalji tal-validazzjoni tal-LLNA u analiżi tax-xogħol assoċjat ġew ippubblikati (2) (3) (4) (5) (6) (7) (8) (9) (10) (11).
English: Table 3 Examples of QC batch release criteria
Italian: Limite di accettabilità inferiore
Romanian: Limita superioară de acceptabilitate
English: Lower acceptance limit Upper acceptance limit
Italian: Limite di accettabilità superiore
Romanian: Limita inferioară de acceptabilitate
English: 2,7 Cat. 2 Cat. 2
Italian: disolfuro di di-n-propile [3]
English: Liquid 3
Italian: Cat.
Romanian: Cat.
Lithuanian: Skystis
English: As a result, the preparations can be scored relatively quickly and analysis can be automated. This makes it practical to score thousands instead of hundreds of cells per treatment, increasing the power of the assay.
Italian: Di conseguenza, i preparati possono essere valutati con relativa rapidità e l’analisi può essere automatizzata, il che permetterebbe di valutare migliaia anziché centinaia di cellule per trattamento, e quindi di accrescere la potenza del saggio.
English: In such cases the choice of the cell lines used should be scientifically justified, e.g. by relevance of the mixed function oxidases for the metabolism of the test substance (51), and their responsiveness to known clastogens and aneugens (see separate section on Acceptability Criteria). It should be recognised that the substance being tested may not be metabolised by the expressed mixed function oxidase(s); in this case, the negative results would not indicate that the test substance cannot induce micronuclei.
Italian: In questi casi la scelta delle linee cellulari deve essere scientificamente motivata (ad esempio, in base all’importanza delle ossidasi a funzione mista nel metabolismo della sostanza in esame (51) e della loro capacità di reagire ai clastogeni e agli aneugeni noti (cfr. la sezione sui criteri di accettabilità). Si deve riconoscere che la sostanza sperimentale non può essere metabolizzata dall’ossidasi o dalle ossidasi a funzione mista espresse; in tal caso, i risultati negativi non indicherebbero che la sostanza sperimentale non causa la formazione di micronuclei.
Dutch: In zulke gevallen moet voor de keuze van de gebruikte cellijnen een wetenschappelijke verantwoording worden gegeven (bv. aan de hand van de relevantie van de oxidasen met gemengde functie voor het metabolisme van de teststof (51), en hun reactievermogen op bekende clastogenen en aneugenen (zie afzonderlijk gedeelte over aanvaardbaarheidscriteria). Er dient te worden erkend dat de geteste stof misschien niet wordt gemetaboliseerd door de tot expressie gekomen oxidase(n) met gemengde functie; in dit geval zouden negatieve resultaten er niet op wijzen dat de teststof geen micronuclei kan induceren.
English: harvest 1,5-2,0 normal cell cycles later. – S9
Italian: procedere alla raccolta a distanza di 1,5–2,0 cicli cellulari normali.
Maltese: ħsad ta’ 1,5–2,0 ċikli ta’ ċelloli normali aktar tard.
English: S9 Extended exposure
Italian: procedere alla raccolta al termine del periodo di esposizione.
English: harvest 1,5-2,0 normal cell cycles later. Cell lines treated without cytoB
Italian: Per i linfociti, l’approccio più efficiente è iniziare l’esposizione alla sostanza sperimentale a distanza di 44-48 ore dopo la stimolazione con PHA, quando la sincronizzazione del ciclo sarà scomparsa (5).
Maltese: Għażla B: Trattament għal 1,5–2,0 ċikli ta’ ċelloli normali;
English: (Identical to the treatment schedules outlined above with the exception that no cytoB is added) Lymphocytes, primary cells, and cell lines with cytoB
Italian: Nel saggio iniziale, le cellule sono trattate per 3 fino a 6 ore con la sostanza sperimentale, con o senza S9.
English: In the initial assay, cells are treated for 3 to 6 hrs with the test substance in the absence and presence of S9. The treatment medium is removed and replaced with fresh medium containing cytoB, and the cells are harvested 1,5-2,0 normal cell cycles later.
Italian: Se entrambi i test iniziali del trattamento breve (3-6 ore) sono negativi o ambigui, si ricorre a un’ulteriore esposizione successiva con S9.
English: If both initial tests of the short (3-6 hrs) treatment are negative or equivocal, a subsequent, extended exposure treatment without S9 is used. Two treatment options are available and are equally acceptable.
Italian: In tal caso sono possibili due opzioni, entrambe accettabili.
English: Appropriate statistical methods may be used as an aid in evaluating the test results (65). However, the results of statistical testing should be assessed with respect to dose-response relationship.
Italian: Si possono usare metodi statistici adeguati come ausilio nella valutazione dei risultati sperimentali (65), ma i risultati delle prove statistiche dovrebbero essere analizzati alla luce del rapporto dose-risposta.
English: The purpose of the pre-screen test is to provide guidance for selecting the maximum dose level to use in the main LLNA: DA study, where information on the concentration that induces systemic toxicity (see paragraph 24) and/or excessive local skin irritation (see paragraph 23) is not available. The maximum dose level tested should be 100 % of the test substance for liquids or the maximum possible concentration for solids or suspensions.
Italian: Scopo del saggio preliminare è fornire informazioni orientative per la selezione della dose massima di utilizzo nel principale studio LLNA: DA, nel caso in cui non siano disponibili informazioni sulla concentrazione che induce tossicità sistemica (cfr. il punto 24)/o eccessiva irritazione cutanea locale (cfr. il punto 23) La dose massima utilizzata nel saggio deve corrispondere al 100 % della sostanza sperimentale per i liquidi o la concentrazione massima possibile per i solidi o le sospensioni.
English: supporting data from the LLNA; supporting data from other animal models and/or from humans.
Lithuanian: apie jas turi būti patvirtinančių duomenų, gautų taikant kitus bandymų su gyvūnais modelius ir (arba) iš žmonių.
English: , The murine local lymph node assay; collaborative studies and new directions: A commentary, Food Chem. Toxicol., 30, 165-169.
Lithuanian: , The murine local lymph node assay; collaborative studies and new directions: A commentary, Food Chem. Toxicol., 30, 165–169.
English: , The local lymph node assay: status of validation, Food Chem. Toxicol., 34, 999-1002.
Lithuanian: , The local lymph node assay: status of validation, Food Chem. Toxicol., 34, 999–1002.
English: , The local lymph node assay: A viable alternative to currently accepted skin sensitisation tests, Food Chem. Toxicol., 34, 985-997.
Lithuanian: , The local lymph node assay: A viable alternative to currently accepted skin sensitisation tests, Food Chem. Toxicol., 34, 985–997.
English: Basketter, D.A., Gerberick, G.F. and Kimber, I. (1998), Strategies for identifying false positive responses in predictive sensitisation tests, Food Chem. Toxicol., 36, 327-33.
Slovak: Basketter, D. A., Gerberick, G. F. and Kimber, I. (1998), Strategies for identifying false positive responses in predictive sensitisation tests, Food Chem. Toxicol., 36, 327 – 333.
Lithuanian: Basketter, D.A., Gerberick, G.F. and Kimber, I. (1998), Strategies for identifying false positive responses in predictive sensitisation tests, Food Chem. Toxicol., 36, 327–33.
English: Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT), Food Chem. Toxicol., 46, 1896-1904.
Slovak: Kreiling, R., Hollnagel, H. M., Hareng, L., Eigler, L., Lee, M. S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT), Food Chem. Toxicol., 46, 1896 – 1904.
Lithuanian: Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT), Food Chem. Toxicol., 46, 1896–1904.
English: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice, Drug. Chem.
Lithuanian: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice, Drug.
English: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods, Drug. Chem.
Lithuanian: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods, Drug.
English: Before a proposed similar or modified in vitro RhE method other than the VRM, EpiDermTM SIT (EPI-200) or SkinEthicTM RHE methods can be used for regulatory purposes, its reliability, relevance (accuracy), and limitations for its proposed use should be determined in order to ensure that it can be regarded as similar to that of the VRM, in accordance with the requirements of the PS set out in this TM (Appendix 2). Moreover, it is recommended to consult the OECD Explanatory Background Document on in vitro skin irritation testing before developing and validating a similar or modified in vitro RhE method and submitting it for regulatory adoption (23).
Lithuanian: Prieš taikant siūlomą panašų arba modifikuotą in vitro RhE metodą, kuris nėra VRM, „EpiDermTM“ SIT (EPI-200) arba „SkinEthicTM“ RHE, reglamentavimo tikslais reikia nustatyti jo patikimumą, tinkamumą (tikslumą) ir siūlomo naudojimo apribojimus, siekiant užtikrinti jo panašumą į VRM, pagal šiame BM nustatytus PS (2 priedėlis) Be to, prieš kuriant panašų ar modifikuotą in vitro RhE metodą, tvirtinant jo tinkamumą ir pateikiant oficialiai patvirtinti, rekomenduojama laikytis OECD aiškinamojo pagrindų dokumento, skirto in vitro odos dirginimo bandymams (23).
English: Liquid 4
Lithuanian: Skystis
English: At the start of the study, animals should be between 8-12 weeks old, and the weight variation of the animals should be minimal and not exceed 20 % of the mean weight. Alternatively, other strains and males may be used when sufficient data are generated to demonstrate that significant strain and/or gender-specific differences in the LLNA: DA response do not exist.
Lithuanian: Pradedant bandymą, gyvūnų amžius turi būti 8–12 savaičių, o gyvūnų masės skirtumas turi būti kiek įmanoma mažesnis ir neviršyti 20 % vidutinės masės Galima naudoti kitas veisles ir patinus, jei yra gauta pakankamai duomenų, kurie rodytų, kad nėra esminių veislei ir (arba) lyčiai būdingų atsako į LLNA: DA skirtumų
English: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice. Drug.
Lithuanian: , Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice.
English: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods. Drug Chem.
Lithuanian: , Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods.
English: At the start of the study, animals should be between 8-12 weeks old, and the weight variation of the animals should be minimal and not exceed 20 % of the mean weight. Alternatively, other strains and males may be used when sufficient data are generated to demonstrate that significant strain and/or gender-specific differences in the LLNA: BrdU-ELISA response do not exist.
Lithuanian: Pradedant bandymą, gyvūnų amžius turi būti 8–12 savaičių, o gyvūnų masės skirtumas turi būti kiek įmanoma mažesnis ir neviršyti 20 % vidutinės masės Galima naudoti kitas veisles ir patinus, jei yra gauta pakankamai duomenų, kurie rodytų, kad nėra esminių veislei ir (arba) lyčiai būdingų atsako į LLNA: BrdU-ELISA skirtumų
English: , The local lymph node assay: status of validation. Food Chem.
Lithuanian: , The local lymph node assay: status of validation.
English: To ensure that a similar or modified LLNA method is functionally and mechanistically analogous to the LLNA and measures the same biological effect, the following components should be included in the test method protocol: The test substance should be applied topically to both ears of the mouse;
Slovenian: Za zagotovitev, da je podobna ali spremenjena metoda LLNA v funkcijskem in mehaničnem smislu podobna LLNA in meri isti biološki učinek, morajo biti v protokol preskusne metode vključeni naslednji elementi:
Latvian: Lai nodrošinātu to, ka LLNA līdzīgā vai modificētā metode funkcionalitātes ziņā vai pēc noteikšanas mehānisma ir analoga LLNA un mēra to pašu bioloģisko iedarbību, testēšanas metodes protokolā jāiekļauj šādi komponenti:
English: Reference Chemicals [1] Chemical
Latvian: References vielas [1]Ķīmiskā viela
English: CAS Number Physical state
Latvian: Fizikālais stāvoklis
English: The MNvit assay is robust and effective in a variety of cell types, and in the presence or absence of cytoB. There are extensive data to support the validity of the MNvit assay using various rodent cell lines (CHO, V79, CHL/IU, and L5178Y) and human lymphocytes (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (30) (31).
Portuguese: O ensaio in vitro de micronúcleos funciona bem numa grande variedade de tipos de células, na presença ou na ausência de citocalasina B. Há numerosos dados que confirmam a validade deste ensaio com várias linhagens de células de roedores (CHO, V79, CHL/IU e L5178Y) e de linfócitos humanos (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (30) (31).
Slovenian: Analiza mikronukleusov in vitro je zanesljiva in učinkovita pri različnih vrstah celic ter ob prisotnosti ali odsotnosti citohalazina B. Na voljo so obširni podatki, ki podpirajo veljavnost analize mikronukleusov in vitro pri različnih celičnih linijah glodavcev (CHO, V79, CHL/IU, in L5178Y) in človeških limfocitih (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (30) (31).
Latvian: MNvit noteikšana ir noturīga un efektīva dažādu tipu šūnās, ar cytoB vai bez tā.
English: Category Chemical
Portuguese: Produto químico
Latvian: Ķīmiskā viela