FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. OJ L 396, 30.12.2006, p. 1.
Spanish: Reglamento (CE) no 1907/2006 del Parlamento Europeo y del Consejo, de 18 de diciembre de 2006, relativo al registro, la evaluación, la autorización y la restricción de las sustancias y preparados químicos (REACH), por el que se crea la Agencia Europea de Sustancias y Preparados Químicos, se modifica la Directiva 1999/45/CE y se derogan el Reglamento (CEE) no 793/93 del Consejo y el Reglamento (CE) no 1488/94 de la Comisión, así como la Directiva 76/769/CEE del Consejo y las Directivas 91/155/CEE, 93/67/CEE, 93/105/CE y 2000/21/CE de la Comisión (DO L 396 de 30.12.2006, p. 1).
Portuguese: Regulamento (CE) n.o 1907/2006 do Parlamento Europeu e do Conselho, de 18 de Dezembro de 2006, relativo ao registo, avaliação, autorização e restrição dos produtos químicos (REACH), que cria a Agência Europeia dos Produtos Químicos, que altera a Directiva 1999/45/CE e revoga o Regulamento (CEE) n.o 793/93 do Conselho e o Regulamento (CE) n.o 1488/94 da Comissão, bem como a Directiva 76/769/CEE do Conselho e as Directivas 91/155/CEE, 93/67/CEE, 93/105/CE e 2000/21/CE da Comissão, JO L 396 de 30.12.2006, p. 1.
Swedish: Europaparlamentets och rådets förordning (EG) nr 1907/2006 av den 18 december 2006 om registrering, utvärdering, godkännande och begränsning av kemikalier (Reach), inrättande av en europeisk kemikaliemyndighet, ändring av direktiv 1999/45/EG och upphävande av rådets förordning (EEG) nr 793/93 och kommissionens förordning (EG) nr 1488/94 samt rådets direktiv 76/769/EEG och kommissionens direktiv 91/155/EEG, 93/67/EEG, 93/105/EG och 2000/21/EG, EUT L 396, 30.12.2006, s. 1.
Hungarian: Az Európai Parlament és a Tanács 1907/2006/EK rendelete (2006. december 18.) a vegyi anyagok regisztrálásáról, értékeléséről, engedélyezéséről és korlátozásáról (REACH), az Európai Vegyianyag-ügynökség létrehozásáról, az 1999/45/EK irányelv módosításáról, valamint a 793/93/EGK tanácsi rendelet, az 1488/94/EK bizottsági rendelet, a 76/769/EGK tanácsi irányelv, a 91/155/EGK, a 93/67/EGK, a 93/105/EK és a 2000/21/EK bizottsági irányelv hatályon kívül helyezéséről, HL L 396, 2006.12.30., 1. o.
English: The protocol is based on information obtained from the Institute for In Vitro Sciences (IIVS) and INVITTOX Protocol 124 (10), which represents the protocol used for the European Community-sponsored prevalidation study of the BCOP assay conducted in 1997-1998. Both of these protocols are based on the BCOP assay methodology first reported by Gautheron et al.
French: Ce protocole s’appuie sur des informations provenant de l’Institute for In Vitro Sciences (IIVS) et sur le protocole INVITTOX no124 (10), qui a été utilisé lors de l’étude de prévalidation de l’essai OPCB conduite en 1997-1998 sous l’égide de la Communauté Européenne.
Italian: Il protocollo si basa su informazioni ottenute dall’Istituto per le scienze in vitro (Institute for In Vitro Sciences, IIVS) e dal protocollo 124 della Banca dati tossicologici in vitro (In-Vitro Toxicology data bank, INVITTOX) (10), che costituisce il protocollo alla base dello studio sulla preconvalida del metodo di prova BCOP finanziato dalla Comunità europea nel 1997-1998.
Portuguese: O protocolo baseia-se na informação obtida do Institute for In Vitro Sciences (IIVS) e no Protocolo 124 do INVITTOX (10), utilizado no estudo de prevalidação do ensaio BCOP que foi efectuado em 1997-1998 com o patrocínio da Comunidade Europeia.
Dutch: Het protocol is gebaseerd op van het Institute for In Vitro Sciences (IIVS) en INVITTOX Protocol 124 (10) verkregen informatie die het door de Europese Gemeenschap gesteunde protocol vertegenwoordigt dat gebruikt werd voor het prevalideringsonderzoek van het in 1997-1998 gevoerde BCOP-onderzoek.
Slovak: Tento protokol vychádza z informácií získaných od Inštitútu pre vedy in vitro a z protokolu INVITTOX 124 (10), ktorý predstavuje protokol používaný pri rozbore predbežnej hodnotiacej štúdie testovacej metódy zákalu a priepustnosti hovädzej rohovky, ktorú financovalo Európske spoločenstvo a ktorá prebehla v rokoch 1997 –1998.
Estonian: Eeskiri põhineb In Vitro Teaduste Instituudis (IIVS) saadud teabel ja INVITTOXi eeskirjal 124 (10), mida kasutati Euroopa Ühenduse rahastatud BCOP-meetodi eelvalideerimisuuringus 1997–1998.
Maltese: Il-protokoll huwa bbażat fuq tagħrif miksub mill-Istitut għax-Xjenzi In Vitro (IIVS) u l-Protokoll 124 INVITTOX (10), li jirrappreżentaw il-protokoll użat għall-istudju tal-prevalidazzjoni tal-assaġġ BCOP, li twettaq bejn l-1997 u l-1998 u li kien sponsorjat mill-Komunità Ewropea.
English: IVIS = mean opacity value + (15 × mean permeability OD490 value) Sina et al.
French: SIIV = valeur moyenne d’opacité + (15 × valeur DO490 de perméabilité moyenne)
Estonian: IVIS = keskmine hägususe väärtus + (15 × keskmine läbilaskvuse OD490 väärtus)
English: Chemical name(s) such as the structural name used by the Chemical Abstracts Service (CAS), followed by other names, if known; The CAS Registry Number (RN), if known;
Estonian: keemiline nimetus või keemilised nimetused, nagu struktuurikohane nimetus, mida kasutab Chemical Abstracts Service (CAS), seejärel muud nimetused, kui need on teada;
English: False positive rate The proportion of all negative substances that are falsely identified by a test method as positive. It is one indicator of test method performance.
Estonian: GHS ( Globally Harmonized System of Classification and Labelling of Chemicals – kemikaalide ühtne ülemaailmne klassifitseerimis- ja märgistamissüsteem)
Latvian: Kļūdaini pozitīvo rezultātu daļa visu to visu to negatīvo vielu daļa bez attiecīgas iedarbības, kas, izmantojot konkrēto testēšanas metodi, nepareizi identificētas kā pozitīvas vielas ar šādu iedarbību.
English: (See Burton et al. (17) for additional generic descriptions of the superfusion apparatus and eye clamp)
French: [Voir Burton et al. (17) pour d'autres descriptions génériques de l'appareil de surfusion et du clamp pour œil]
Italian: (cfr Burton et al. (17) per ulteriori descrizioni generiche dell’apparecchio di superfusione e del morsetto oculare)
Portuguese: (Ver em Burton et al. (17) uma descrição genérica dos suportes oculares e do aparelho de superfusão para o método ICE)
Dutch: (Zie Burton et al. (17) voor een bijkomende generische beschrijving van superfusieapparaat en oogklem)
Slovak: [Ďalší generický všeobecný opis superfúzneho prístroja a očnej svorky pozri v publikácii Burton et al. (17)]
Estonian: (Tilgutusaparaadi ja silmahoidja üldise täiendava kirjelduse on esitanud Burton et al. (17))
English: Hazard Inherent property of an agent or situation having the potential to cause adverse effects when an organism, system or (sub) population is exposed to that agent. In Vitro Irritancy Score (IVIS)
Finnish: Vaara Vaikuttavan tekijän (”agentin”) tai tilanteen sisäinen ominaisuus, jolla on kyky aiheuttaa haitallisia vaikutuksia, kun organismi, järjestelmä tai (ala)populaatio altistuu kyseiselle aineelle.
English: Each of the inner chambers is 1,7 cm in diameter and 2,2 cm in depth [1]. An o-ring located on the posterior chamber is used to prevent leaks.
Finnish: Kunkin sisäkammion halkaisija on 1,7 cm ja syvyys 2,2 cm [1] Takakammiossa on tiivisterengas vuotojen estämiseksi.
English: DATA AND REPORTING Data Evaluation
Finnish: Mittaustulosten arviointi
English: Once the medium is free of test substance, the corneas are given a final rinse with EMEM (without phenol red). The EMEM (without phenol red) is used as a final rinse to ensure removal of the phenol red from the anterior chamber prior to the opacity measurement.
French: Une fois le milieu débarrassé de la substance, les cornées subissent un dernier rinçage avec un MEM sans rouge de phénol, ce qui permet de s’assurer que la chambre antérieure est débarrassée de tout rouge de phénol avant la mesure d’opacité.
Portuguese: Quando o meio já não contiver a substância em estudo, lavam-se as córneas uma última vez utilizando EMEM sem vermelho de fenol, para garantir a remoção deste último da câmara anterior antes da medição de opacidade.
English: For eyes that are not rejected based on any of these criteria, individual eyes with a corneal thickness deviating more than 10 % from the mean value for all eyes are to be rejected. Users should be aware that slit-lamp microscopes could yield different corneal thickness measurements if the slit-width setting is different.
French: Les yeux qui ne sont pas rejetés sur la base de ces critères, mais dont l'épaisseur cornéenne s'écarte de plus de 10 % de la valeur moyenne calculée pour l'ensemble des yeux doivent également être rejetés.
English: The time interval between collection of the eyes and use of corneas in the BCOP should be minimized (typically collected and used on the same day) and should be demonstrated to not compromise the assay results. These results are based on the selection criteria for the eyes, as well as the positive and negative control responses.
Hungarian: A szemek begyűjtése és a szaruhártyának a BCOP vizsgálatban való felhasználása között eltelt időnek a lehető legrövidebbnek kell lennie (a begyűjtésnek és a felhasználásnak rendszerint ugyanazon a napon meg kell történnie), és igazolni kell, hogy ez az idő nem befolyásolja a vizsgálat eredményeit, azaz a szemek kiválasztási kritériumait, valamint a pozitív és a negatív kontrollminták eredményeit.
English: Washington, DC: U.S. Environmental Protection Agency.
Swedish: Environmental Protection Agency.
Hungarian: Washington, DC: US Environmental Protection Agency.
English: The time interval between collection of the chicken heads and use of eyes in the ICE test method should be minimized (typically within two hours) and should be demonstrated to not compromise the assay results. These results are based on the selection criteria for the eyes, as well as the positive and negative control responses.
Hungarian: A fejek begyűjtése és a szemeknek az ICE vizsgálatban való felhasználása között eltelt időnek a lehető legrövidebbnek kell lennie (mindennek rendszerint két órán belül meg kell történnie), és igazolni kell, hogy ez az idő nem befolyásolja a vizsgálat eredményeit, azaz a szemek kiválasztási kritériumait, valamint a pozitív és negatív kontrollminták eredményeit.
English: Sina et al. (16) reported that this formula was derived during in-house and inter-laboratory studies.
Italian: Secondo Sina et al. (16) suddetta formula è stata ottenuta grazie a studi interni e inter-laboratorio.
Portuguese: Sina et al. (16) referiram que esta fórmula foi estabelecida com base em estudos no seu laboratório e interlaboratoriais.
Dutch: Sina et al. (16) schreef dat deze formule afgeleid was tijdens onderzoeken in eigen laboratorium en interlaboratoriumonderzoeken.
English: Increased corneal opacity is indicative of damage to the cornea. Opacity can be evaluated subjectively as done in the Draize rabbit eye test, or objectively with an instrument such as an ‘opacitometer’.
Italian: Affidabilità misura la possibilità di eseguire un metodo di prova in maniera riproducibile nel tempo all’interno dei laboratori e fra di essi seguendo lo stesso protocollo.
English: EU Category R41 Production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the anterior surface of the eye, which is not fully reversible within 21 days of application (2). False negative rate The proportion of all positive substances falsely identified by a test method as negative. It is one indicator of test method performance. False positive rate The proportion of all negative substances that are falsely identified by a test method as positive. It is one indicator of test method performance. GHS (Globally Harmonized System of Classification and Labelling of Chemicals) A system proposing the classification of chemicals (substances and mixtures) according to standardized types and levels of physical, health and environmental hazards, and addressing corresponding communication elements, such as pictograms, signal words, hazard statements, precautionary statements and safety data sheets, so that to convey information on their adverse effects with a view to protect people (including employers, workers, transporters, consumers and emergency responders) and the environment (3).
Italian: Categoria GHS 1 produzione di danni ai tessuti oculari o indebolimento grave della vista in seguito all’applicazione di una sostanza di prova sulla parte anteriore dell’occhio, non completamente reversibile entro 21 giorni dall’applicazione (3).
English: When tested with a concurrent negative control, this sample also demonstrates whether the solvent or vehicle interacts with the test system. Tiered testing A stepwise testing strategy where all existing information on a test substance is reviewed, in a specified order, using a weight of evidence process at each tier to determine if sufficient information is available for a hazard classification decision, prior to progression to the next tier.
Italian: Prove in sequenza strategia di prove graduali in cui sono riesaminate tutte le informazioni disponibili su una sostanza di prova, secondo un ordine ben specificato, seguendo un approccio basato sulla forza probante dei dati disponibili per ciascuna prova, al fine di stabilire se vi sono informazioni sufficienti per una decisione sulla classificazione del pericolo prima di procedere alla fase successiva.
English: It is expressed as a percentage and is calculated from baseline (pre-dose) corneal thickness measurements and the thickness recorded at regular intervals after exposure to the test material in the ICE test. The degree of corneal swelling is indicative of damage to the cornea.
Italian: É valutata calcolando la riproducibilità interna ai laboratori e la ripetibilità fra i laboratori.
English: EU Category R41 Production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the anterior surface of the eye, which is not fully reversible within 21 days of application (2). False negative rate The proportion of all positive substances falsely identified by a test method as negative. It is one indicator of test method performance. False positive rate The proportion of all negative substances that are falsely identified by a test method as positive. It is one indicator of test method performance. Fluorescein retention A subjective measurement in the ICE test of the extent of fluorescein sodium that is retained by epithelial cells in the cornea following exposure to a test substance. The degree of fluorescein retention is indicative of damage to the corneal epithelium. GHS (Globally Harmonized System of Classification and Labelling of Chemicals) A system proposing the classification of chemicals (substances and mixtures) according to standardized types and levels of physical, health and environmental hazards, and addressing corresponding communication elements, such as pictograms, signal words, hazard statements, precautionary statements and safety data sheets, so that to convey information on their adverse effects with a view to protect people (including employers, workers, transporters, consumers and emergency responders) and the environment (3).
Italian: Categoria GHS 1 produzione di danni ai tessuti oculari o indebolimento grave della vista in seguito all’applicazione di una sostanza di prova sulla parte anteriore dell’occhio, non completamente reversibile entro 21 giorni dall’applicazione (3).
English: Available: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_bcop.htm]
Swedish: http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_bcop.htm
Lithuanian: Paskelbta: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_bcop.htm]
English: Corneas are exposed to liquids and surfactants for 10 minutes. Use of other exposure times should be accompanied by adequate scientific rationale.
Latvian: Šķidrumu un virsmaktīvo vielu iedarbībai radzenes pakļauj 10 min. Ja izmanto citu iedarbības laiku, tam jāsniedz pienācīgs zinātnisks pamatojums.
English: Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse. Can.
Latvian: Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse.Can.
English: BSE: A decade on - Part I. The Lancet 349: 636-641.
Portuguese: BSE: A decade on - Part I. The Lancet 349:636-641.
Slovak: The Lancet 349:636 – 641.
Latvian: BSE: A decade on - Part I. The Lancet 349:636-641.
English: Sina, J.F., Galer, D.M., Sussman, R.S., Gautheron, P.D., Sargent, E.V., Leong, B., Shah, P.V., Curren, R.D., and Miller, K. (1995). A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates.
Latvian: Sina, J.F., Galer, D.M., Sussman, R.S., Gautheron, P.D., Sargent, E.V., Leong, B., Shah, P.V., Curren, R.D., and Miller, K. (1995).
English: Fundam Appl Toxicol 26:20-31.
Dutch: Toxicol 26:20-31.
Slovak: Fundam Appl Toxicol 26:20 – 31.
Latvian: A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates.Fundam Appl Toxicol 26:20-31.
English: Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits. Fd.
Latvian: Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits.Fd.
English: The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicol.
Latvian: The EC/HO international validation study on alternatives to the Draize eye irritation test.Toxicol.
English: The chicken enucleated eye test (CEET): A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials. Food Chem.
Slovak: The chicken enucleated eye test (CEET): A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials [Testovanie vylúpnutých kuracích očí: praktická (predbežná) kontrola na hodnotenie schopnosti testovaných materiálov vyvolať očné podráždenie/žieravý účinok].
Latvian: The chicken enucleated eye test (CEET): A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials.Food Chem.
English: IRAG Working Group I: Organotypic models for the assessment/prediction of ocular irritation. Food Chem.
Latvian: IRAG Working Group I: Organotypic models for the assessment/prediction of ocular irritation.Food Chem.
English: Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays.
Slovak: Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays (Rozsah poranení rohovky ako mechanický základ podráždenia očí: hlavné zistenia a odporúčania na vývoj alternatívnych rozborov).
Latvian: Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays.Reg.
English: Reg. Tox.
Latvian: Tox.
English: The in vitro assessment of severe irritants. Fd.
Latvian: The in vitro assessment of severe irritants.Fd.
English: A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates.
Portuguese: A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates. Fundam. Appl. Toxicol.
Dutch: A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates. Fundam. Appl.
Slovak: A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates (Spolupráca pri posudzovaní siedmich alternatív k Draize testu dráždivosti očí s použitím farmaceutických medziproduktov).
English: In Vitro 9:871-929.
Dutch: In Vitro 9: 871-929.
Swedish: In Vitro 9:871–929.
English: The in vitro assessment of severe irritants.
Portuguese: The in vitro assessment of severe irritants. Fd. Cosmet.
Dutch: The in vitro assessment of severe irritants. Fd. Cosmet.
Swedish: Cosmet.
Slovak: The in vitro assessment of severe irritants (Hodnotenie silne dráždivých látok in vitro).
English: Gautheron, P., Dukic, M., Alix, D. and Sina, J.F. (1992).
Portuguese: Gautheron, P., Dukic, M., Alix, D., Sina, J. F. (1992).
Swedish: Gautheron, M. Dukic, D. Alix och J. F. Sina (1992), ”Bovine corneal opacity and permeability test: An in vitro assay of ocular irritancy”, Fundam.
English: [http://www.cdc.gov/ncidod/dhqp/pdf].
Portuguese: http://www.cdc.gov/ncidod/dhqp/pdf
English: Maurer, J.K., Parker, R.D. and Jester, J.V. (2002).
Portuguese: Maurer, J. K., Parker, R. D., Jester, J. V. (2002).
Swedish: Maurer, R. D. Parker och J. V. Jester (2002), ”Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays”, Reg.
English: The BCOP corneal holders are made of an inert material (e.g., polypropylene). The holders are comprised of two halves (an anterior and posterior chamber), and have two similar cylindrical internal chambers.
Portuguese: Os suportes de córnea utilizados no método BCOP são feitos de um material inerte (por exemplo, polipropileno) e constituídos por duas metades (uma anterior e outra posterior), possuindo duas câmaras cilíndricas internas semelhantes.
English: Two holes on the top of each chamber permit introduction and removal of medium and test compounds. They are closed with rubber caps during the treatment and incubation periods.
Portuguese: Para se poder introduzir e remover o meio de ensaio e os compostos em estudo, existem dois orifícios na parte superior de cada câmara, que são fechados com tampas de borracha durante os períodos de tratamento e incubação.
English: The enucleated eye is mounted in a stainless steel clamp with the cornea positioned vertically. The clamp is then transferred to a chamber of the superfusion apparatus (16).
Portuguese: Coloca-se o olho desorbitado num suporte de aço inoxidável, com a córnea na vertical, e transfere-se o conjunto para uma das câmaras do aparelho de superfusão (16).
English: Prinsen, M.K. (1996).
Portuguese: Prinsen, M. K. (1996).
Swedish: Prinsen, (1996), ”The chicken enucleated eye test (CEET), A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials”, Food Chem.
English: Chamberlain, M., Gad, S.C., Gautheron, P. and Prinsen, M.K. (1997).
Portuguese: Chamberlain, M., Gad, S. C., Gautheron, P., Prinsen, M. K. (1997).
Swedish: Chamberlain, S. C. Gad, P. Gautheron och M. K. Prinsen, (1997), ”IRAG Working Group I: Organotypic models for the assessment/prediction of ocular irritation”, Food Chem.
English: [http://www.cdc.gov/ncidod/dhqp/pdf/isolation2007.pdf].
Portuguese: http://www.cdc.gov/ncidod/dhqp/pdf/isolation2007.pdf
English: Maurer, J.K., Parker, R.D. and Jester J.V. (2002).
Portuguese: Maurer, J. K., Parker, R. D., Jester J. V. (2002).
Swedish: Maurer, R. D. Parker och J. V. Jester (2002), ”Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays”, Reg.
English: Burton, A.B.G., M. York and R.S. Lawrence (1981).
Portuguese: Burton, A. B. G., M. York, R. S. Lawrence (1981).
Swedish: Burton, M. York och R. S. Lawrence (1981), ”The in vitro assessment of severe irritants”, Fd.
English: The holder is then incubated in a horizontal position for 90 ± 5 min at 32 ± 1 °C. The amount of sodium fluorescein that crosses into the posterior chamber is quantitatively measured with the aid of UV/VIS spectrophotometry.
Romanian: Cantitatea de fluoresceină sodică care pătrunde în camera posterioară este măsurată cantitativ cu ajutorul unui spectrofotometru UV/VIS.