FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: The fluorescein permeability values are determined using OD490 values based upon a visible light spectrophotometer using a standard 1 cm path length. 41. Alternatively, a 96-well microtiter plate reader may be used provided that; (i) the linear range of the plate reader for determining fluorescein OD490 values can be established; and (ii), the correct volume of fluorescein samples are used in the 96-well plate to result in OD490 values equivalent to the standard 1 cm path length (this could require a completely full well [usually 360 mL]).
Romanian: Ca o variantă alternativă, se poate utiliza un cititor de plăci cu 96 de godeuri cu microtitrare cu condiția: (i) să se poată stabili domeniul linear al cititorului de plăci pentru determinarea valorilor DO490 a fluoresceinei; și (ii) să se utilizeze volumul corect de mostre de fluoresceină în placa cu 96 de godeuri pentru a se obține valori ale DO490 echivalente cu valoarea standard de 1 cm a lungimii traiectoriei [acest aspect ar putea necesita un godeu umplut complet (în mod obișnuit 360 μl)].
English: As stated in paragraph 1, if the test substance is not identified as an ocular corrosive or severe irritant, additional testing should be conducted for classification and labelling purposes. The BCOP test method has an overall accuracy of 79 % (113/143) to 81 % (119/147), a false positive rate of 19 % (20/103) to 21 % (22/103), and a false negative rate of 16 % (7/43) to 25 % (10/40), when compared to in vivo rabbit eye test method data classified according to the EPA (1), EU (2), or GHS (3) classification systems.
Romanian: Prin comparație cu datele metodei de testare in vivo pe ochi de iepure, clasate în conformitate cu sistemele de clasificare EPA (1), UE (2) sau GHS (3), metoda de testare BCOP are o precizie totală cuprinsă între 79 % (113/143) și 81 % (119/147), o rată de rezultate fals pozitive cuprinsă între 19 % (20/103) și 21 % (22/103), și o rată de rezultate fals negative cuprinsă între 16 % (7/43) și 25 % (10/40).
English: Washington, DC: U.S.
Romanian: Washington DC: U.S.
English: Table 1 Recommended substances for demonstrating technical proficiency with BCOP
Romanian: Clasă chimică [1]
English: Abbreviations: CASRN = Chemical Abstracts Service Registry Number Substance CASRN Chemical Class [1] Physical Form
Romanian: Formă fizică:
English: Amine, Amidine Solid
Romanian: Categoria 1
English: Category 1 Corrosive/Severe Irritant
Romanian: Coroziv/Iritant sever
English: Corneal opacity scores Score
Romanian: Observații
English: Observation 0No opacity
Romanian: 0Absența opacității
English: Environmental Protection Agency.
Slovak: Environmental Protection Agency (Agentúra USA pre ochranu životného prostredia).
English: Bovine corneal opacity and permeability test: An in vitro assay of ocular irritancy.
Slovak: Bovine corneal opacity and permeability test: An in vitro assay of ocular irritancy (Testovanie zákalu a priepustnosti hovädzej rohovky: rozbor dráždivosti očí in vitro).
English: Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse.
Slovak: Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse (Anatómia a morfológia rohoviek hovädzích očí z bitúnka).
English: Zool. 73:2159-2165.
Slovak: Zool. 73:2159 – 2165.
English: Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits.
Slovak: Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits (Dôvody na testovanie vylúpnutých očí na očiach jatočných zvierat ako alternatívy k Draize testu dráždivosti na králikoch).
English: The EC/HO international validation study on alternatives to the Draize eye irritation test.
Slovak: The EC/HO international validation study on alternatives to the Draize eye irritation test (Medzinárodná hodnotiaca štúdia ES/humanitárnych organizácií o alternatívach k Draize testu očnej dráždivosti).
English: Toxicol.
Slovak: Food Chem. Toxicol.
English: Cosmet.- Toxicol.- 19, 471-480.
Slovak: Cosmet.- Toxicol.- 19, 471 – 480.
English: Ocular corrosive (a) A substance that causes irreversible tissue damage to the eye. (b) Substances that are classified as GHS Category 1, EPA Category I, or EU Category R41 ocular irritants (1)(2)(3).
Slovenian: Jedka snovi za oči (a) snov, ki povzroča ireverzibilno poškodbo očesnega tkiva; (b) snovi, ki so razvrščene v GHS kategorijo 1, EPA kategorijo I ali EU kategorijo R41 dražilnih snovi za oči (1) (2) (3).
English: For this reason, irritant substances were selected from the ICCVAM recommended list of 122 reference substances for the validation of in vitro ocular toxicity test methods (see Appendix H, ICCVAM Recommended Reference Substances List)(4). Reference data are available in the ICCVAM Background Review Documents for the Bovine Corneal Opacity and Permeability (BCOP) and the ICE test methods (18) (19).
Slovenian: Zaradi tega so bile dražilne snovi izbrane iz priporočenega seznama ICCVAM, ki vsebuje 122 referenčnih snovi za validacijo testnih metod in vitro za ugotavljanje toksičnosti za oči (glej dodatek H: Referenčni podatki so zbrani v dokumentih ICCVAM o pregledu ozadja testne metode BCOP in testne metode ICE na izoliranih očeh piščancev (18) (19).
English: EPA (1996). Label Review Manual: 2nd Edition. EPA737-B-96-001.
Swedish: EPA (1996), Label Review Manual, andra utgåvan, EPA737-B-96-001, Washington, DC, U.S.
English: Globally Harmonized System of Classification and Labelling of Chemicals (GHS). Second revised edition, New York & Geneva: United Nations Publications, 2007. Available: [http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html]
Swedish: http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html
English: ESAC (2007). Statement on the conclusion of the ICCVAM retrospective study on organotypic in vitro assays as screening tests to identify potential ocular corrosives and severe eye irritants.
Swedish: ESAC (2007), Statement on the conclusion of the ICCVAM retrospective study on organotypic in vitro assays as screening tests to identify potential ocular corrosives and severe eye irritants, finns på
English: Available: [http://ecvam.jrc.it/index.htm]
Swedish: http://ecvam.jrc.it/index.htm
English: Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Ocular Severe Irritants and Corrosives. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NIH Publication No: 07-4517. Available: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_tmer.htm]
Swedish: http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_tmer.htm
English: OECD (2002). Test Guideline 405.
Swedish: OECD (2002), Test Guideline 405.
English: Acute eye irritation/corrosion. Available:
Swedish: Acute eye irritation/corrosion, finns på
English: ICCVAM (2007). ICCVAM Recommended BCOP Test Method Protocol.
Swedish: ICCVAM (2007), ICCVAM:s rekommenderade testprotokoll för BCOP-testmetoden, ”ICCVAM Test Method Evaluation Report – In Vitro Ocular Toxicity Test Methods for Identifying Ocular Severe Irritants and Corrosives”, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), NIH:s publikation nr: 07-4517, finns på
English: In: ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Ocular Severe Irritants and Corrosives. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NIH Publication No: 07-4517. Available: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_tmer.htm]
Swedish: http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_tmer.htm
English: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability Test Method. NIH Publication No: 06-4512. Research Triangle Park: National Toxicology Program. Available: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_ice.htm]
Swedish: http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_ice.htm
English: INVITTOX (1999). Protocol 124: Bovine Corneal Opacity and Permeability Assay – SOP of Microbiological Associates Ltd. Ispra, Italy: European Centre for the Validation of Alternative Methods (ECVAM).
Swedish: INVITTOX (1999), Protocol 124: Bovine Corneal Opacity and Permeability Assay – SOP of Microbiological Associates Ltd, Ispra, Italien: Europeiska centret för bestämning av alternativa metoder (ECVAM).
English: Bovine corneal opacity and permeability test: An in vitro assay of ocular irritancy. Fundam. Appl. Toxicol.
Swedish: Appl.
English: Siegel, J.D., Rhinehart, E., Jackson, M., Chiarello, L., and the Healthcare Infection Control Practices Advisory Committee (2007). Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings.
Swedish: Siegel, E. Rhinehart, M. Jackson, L. Chiarello och Healthcare Infection Control Practices Advisory Committee (2007), Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings, finns på
English: Available: [http://www.cdc.gov/ncidod/dhqp/pdf].
Swedish: http://www.cdc.gov/ncidod/dhqp/pdf
English: Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays. Reg. Tox. Pharmacol.
Swedish: Tox.
English: Doughty, M.J., Petrou, S. and Macmillan, H. (1995). Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse. Can.
Swedish: Doughty, S. Petrou och H. Macmillan (1995), ”Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse”, Can.
English: Collee, J. and Bradley, R. (1997). BSE: A decade on - Part I. The Lancet 349: 636-641.
Swedish: Collee och R. Bradley (1997), ”BSE: A decade on – Part I”, The Lancet 349: 636–641.
English: Sina, J.F., Galer, D.M., Sussman, R.S., Gautheron, P.D., Sargent, E.V., Leong, B., Shah, P.V., Curren, R.D., and Miller, K. (1995). A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates. Fundam Appl Toxicol 26:20-31.
Swedish: Sina, D. M. Galer, R. S. Sussman, P. D. Gautheron, E. V. Sargent, B. Leong, P. V. Shah, R. D. Curren och K. Miller (1995), ”A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates”, Fundam Appl Toxicol 26:20–31.
English: ICCVAM (2006). Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method.
Swedish: ICCVAM (2006), Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method, finns på
English: ICCVAM (2006). Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method.
Swedish: ICCVAM (2006), Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method, finns på
English: 2 × IV, 1 × III 2 × IV, 1 × II [4]2 × IV, 1 × I [4]Corneal opacity ≥ 3 at 30 min (in at least 2 eyes)
Swedish: 2 × IV, 1 × III [4]2 × IV, 1 × I [4]Korneal opacitet ≥ 3 vid 30 min. (minst två ögon)
English: United nations (UN) (2007). Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Second revised edition, UN New York and Geneva, 2007.
Swedish: Förenta nationerna (FN) (2007), Globally Harmonized System of Classification and Labelling of Chemicals (GHS), andra reviderade upplagan, FN New York och Genève, 2007, finns på
English: Available at: [http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html]
Swedish: http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html
English: Available: [http://ecvam.jrc.it/index.htm].
Swedish: http://ecvam.jrc.it/index.htm
English: ICCVAM (2007). ICCVAM Recommended ICE Test Method Protocol.
Swedish: ICCVAM (2007), ICCVAM:s rekommenderade testprotokoll för ICE-testmetoden, ingår i ”ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Ocular Severe Irritants and Corrosives”, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Centre for the Evaluation of Alternative Toxicological Methods (NICEATM), NIH:s publikation nr: 07-4517, finns på
English: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye Test Method. NIH Publication No: 06-4513.
Swedish: Research Triangle Park: National Toxicology Program, finns på
English: Research Triangle Park: National Toxicology Program. Available: [http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_ice.htm]
Swedish: http://iccvam.niehs.nih.gov/methods/ocutox/ivocutox/ocu_brd_ice.htm
English: Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits. Fd.
Swedish: Koëter, (1993), ”Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits”, Fd.
English: INVITTOX (1994). Protocol 80: Chicken enucleated eye test (CEET).
Swedish: INVITTOX (1994), Protocol 80: Chicken enucleated eye test (CEET), finns på
English: Balls, M., Botham, P.A., Bruner, L.H. and Spielmann H. (1995). The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicol.
Swedish: Balls, P. A Botham, L. H. Bruner och H. Spielmann, (1995), ”The EC/HO international validation study on alternatives to the Draize eye irritation test”, Toxicol.
English: The chicken enucleated eye test (CEET): A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials. Food Chem. Toxicol.
Swedish: Toxicol.
English: IRAG Working Group I: Organotypic models for the assessment/prediction of ocular irritation. Food Chem. Toxicol.
Swedish: Toxicol.
English: Available: [http://www.cdc.gov/ncidod/dhqp/pdf/isolation2007.pdf].
Swedish: http://www.cdc.gov/ncidod/dhqp/pdf/isolation2007.pdf
English: ICCVAM (2006). Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe IrritantsIsolated Chicken Eye (ICE) Test Method.
Swedish: ICCVAM (2006), Background review document, Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method, finns på