FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: Decant and blot EBSS/PBS totally. (Optionally: centrifuge reversed plate.)
French: Décanter et absorber complètement le EBSS/PBS (facultatif: centrifuger la plaque retournée).
Spanish: Se decanta y se absorbe completamente la EBSS/PBS (Facultativo: centrifugado de la placa invertida).
Lithuanian: Praplovimui skirtas tirpalas nupilamas ir plokštelė visiškai išdžiovinama, centrifuguojant ją apgręžiamuoju būdu.
English: The negative control OD value represents 100 % cell viability; hence, the OD values obtained for each test sample can be used to calculate a percentage viability relative to the negative control.
Italian: Il valore della DO del controllo negativo rappresenta il 100 % della vitalità cellulare, di conseguenza i valori DO ottenuti per ciascun campione da saggiare possono essere utilizzati per calcolare una percentuale di vitalità del controllo negativo.
Portuguese: O valor de DO do controlo negativo representa 100 % de viabilidade celular, pelo que os valores obtidos para cada amostra de ensaio poderão ser utilizados para calcular uma percentagem de viabilidade relativa em relação ao controlo negativo.
Dutch: De OD-waarde van de negatieve controle komt overeen met een levensvatbaarheid van de cellen van 100 %, zodat de voor elk testmonster bepaalde OD-waarden kunnen worden gebruikt voor de berekening van een procentuele levensvatbaarheid in vergelijking met de negatieve controle.
Swedish: Ett negativt OD-kontrollvärde betyder 100 % viabilitet för cellerna och därför kan de OD-värden som fås för vart och ett prov användas för att beräkna en procentuell viabilitet i förhållande till den negativa kontrollen.
Polish: Wartość OD dla kontroli negatywnej oznacza 100 % żywotność komórek, tak więc na podstawie wartości OD uzyskanych dla każdej próbki badanej można obliczyć procentową żywotność względem kontroli negatywnej.
Estonian: Negatiivse kontrolli korral saadud OD väärtused vastavad rakkude 100 % eluvõimelisusele, seega saab iga uuritava proovi korral saadud OD väärtusi kasutada eluvõimelisuse protsendi arvutamiseks negatiivse kontrolli suhtes.
Lithuanian: Neigiamos kontrolės optinio tankio reikšmė atspindi šimtaprocentinį ląstelių gyvybingumą, taigi kiekvieno tiriamojo mėginio optinio tankio reikšmės gali būti panaudotos apskaičiuoti gyvybingumo, palyginus su neigiama kontrole, procentais išreikštą reikšmę.
English: The pelt is placed over the end of a polytetrafluoroethylene (PTFE) tube, ensuring that the epidermal surface is in contact with the tube. A rubber 'O' ring is press-fitted over the end of the tube to hold the skin in place and excess tissue is trimmed away.
Italian: Il lembo cutaneo così ottenuto viene posizionato sull'estremità di una provetta in PTFE (politetrafluoroetilene) in modo che la superficie epidermica sia a contatto con la provetta, viene quindi fissato all'estremità della provetta mediante una ghiera inserita a pressione ed infine vengono eliminati gli orli di pelle debordante.
English: The sulforhodamine B dye content per disc is calculated from the OD values (sulforhodamine B dye molar extinction coefficient at 565 nm = 8,7 × 104; molecular weight = 580).
German: Der Gehalt an Sulforhodamin B-Farbstoff je Hautstück wird mittels der OD-Werte berechnet (molarer Extintionskoeffizient von Sulforhodamin B bei 565 nm = 8,7 × 104, Molekulargewicht = 580).
Dutch: Het gehalte aan de kleurstof sulforhodamine B wordt berekend uit de OD-waarde (de molaire extinctiecoëfficiënt van de kleurstof sulforhodamine B bij 565 nm = 8,7 × 104 en het molecuulgewicht = 580).
Hungarian: Az OD-értékekből kiszámítják a szulforodamin B festéktartalmat korongonként (szulforodamin B festék moláris extinciós együtthatója 565 nm = 8,7 × 104; molekulasúly = 580).
Slovenian: Vsebnost barvila sulforhodamin B v ploščici se izračuna iz vrednosti OD (koeficient molarne ekstinkcije barvila sulforhodamin B pri 565 nm = 8,7 × 104; molska masa = 580).
Bulgarian: Съдържанието на багрилото сулфородамин Б във всяка проба се изчислява според стойностите на оптичната плътност ( коефицентът на моларна екстинкция на сулфородамин Б при дължина на вълната 565 nm = 8,7 × 10; молекулярно тегло = 580).
Maltese: Il-kontenut tal-kulur sulforhodamine B kull diska huwa kkalkolat mill-valuri OD (koeffiċjent molari kulur sulforhodamine B f'565 nm = 8,7 7 × 104; piż molekolari = 580).
English: Corrosive materials are identified by their ability to produce a loss of normal stratum corneum integrity and barrier function, which is measured as a reduction in the inherent TER below a threshold level (5 k]ISO_7]Ù) (4) (5).
Portuguese: Os materiais corrosivos são identificados pela sua capacidade de causarem uma perda da integridade normal do stratum corneum e da função de barreira, perda essa que é medida pela redução do TER intrínseco abaixo de um determinado limiar (5 k]ISO_7]Ù) (4) (5).
English: ISO_1]Irritant and non-irritant materials do not reduce the TER below the threshold level.
Portuguese: ISO_1]Os materiais simplesmente irritantes e os materiais não irritantes não reduzem o TER abaixo desse limiar.
English: The databridge electrodes are placed on either side of the skin disc to take the resistance measurement in k]ISO_7]Ù/]ISO_1]skin disc (Figure 2).
Portuguese: Os eléctrodos do databridge são colocados em duas extremidades do disco de pele de forma a medir a resistência em k]ISO_7]Ù/]ISO_1]disco (figura 2).
English: Note that if the measured resistance value is greater than 20 k]ISO_7]Ù, ]ISO_1]this may be due to the test substance coating the epidermal surface of the sking disc.
Portuguese: De notar que nos casos em que seja medida uma resistência superior a 20 k]ISO_7]Ù, ]ISO_1]isso se poderá dever ao facto de a substância de ensaio estar a impedir o acesso da solução ao disco de epiderme.
English: If the TER values of test substances which are either surfactants or neutral organics are less than or equal to 5 k]ISO_7]Ù, ]ISO_1]an assessment of dye penetration can be carried out on the tissues.
Portuguese: Se os valores de TER das substâncias de ensaio que sejam tensioactivas ou que sejam substâncias orgânicas neutras forem inferiores ou iguais a 5 k]ISO_7]Ù, ]ISO_1]poderá proceder-se a uma avaliação da penetração de corantes nos tecidos.
English: The 5 k]ISO_7ISO_1]corrosive threshold was developed from data obtained with the specific apparatus and procedure described in this method.
Portuguese: O limiar de corrosão de 5 k]ISO_7ISO_1]foi desenvolvido a partir dos dados obtidos com o aparelho e com os procedimentos descritos no presente método.
English: Resistance values (k]ISO_7]Ù) ]ISO_1]for the test material, positive and negative controls, and any standard reference chemicals should be reported in tabular form, including data for replicates/repeat experiments, mean values and the classification derived.
Portuguese: Os valores de resistência (k]ISO_7]Ù) ]ISO_1]do material de ensaio, dos controlos positivo e negativo e de qualquer produto químico padrão utilizado deverão ser apresentados sob a forma de uma tabela, incluindo todos os dados relativos aos replicados/repetição de experiências, os valores médios e as classificações daí deduzidas em termos de corrosividade.
English: If the mean TER value obtained for the test substance is greater than 5 k]ISO_7]Ù, ]ISO_1]then it is non-corrosive.
Portuguese: Caso o valor médio de TER obtido para a substância de ensaio seja superior a 5 k]ISO_7]Ù, ]ISO_1]a substância é considerada não corrosiva.
English: If the TER value is less than or equal to 5 k]ISO_7]Ù, ]ISO_1]and the test substance is not a surfactant or neutral organic, then it is corrosive.
Portuguese: Se o valor do TER for inferior a ou igual a 5 k]ISO_7ISO_1]e se a substância em causa não for tensioactiva nem um composto orgânico neutro, será considerada corrosiva.
English: For surfactants or neutral organics which give TER values less than or equal to 5 k]ISO_7]Ù, ]ISO_1]dye penetration can be carried out.
Portuguese: Se a substância for tensioactiva ou um composto orgânico neutro e se o valor de TER for inferior ou igual a 5 k]ISO_7]Ù, ]ISO_1]poderá proceder-se a um tratamento com corante.
English: [REF]ERENCES
Portuguese: 4 BIBLIOGRAFIA
English: PIC FILE= "L_2000136EN.009601.TIF"]
Portuguese: PIC FILE= "L_2000136PT.009601.TIF"]
English: PIC FILE= "L_2000136EN.009701.TIF"]"
Portuguese: PIC FILE= "L_2000136PT.009701.TIF"]"
English: A test meets the acceptance criteria if the mean OD540 NRU of untreated controls is ] = 0,2.
Portuguese: O ensaio satisfaz os critérios se a densidade óptica média (OD540 NRU) das amostras de controlo não tratadas for igual ou superior a 0,2.
English: PIC FILE= "L_2000136EN.010101.EPS"]
Portuguese: PIC FILE= "L_2000136PT.010101.EPS"]
English: Alternatively, variation of the pre-irradiation incubation time may be considered. A shorter time can be relevant for water-unstable chemicals.
German: Als Alternative kann auch eine Änderung der Inkubationszeit vor der Bestrahlung in Betracht gezogen werden, wie z. B. kürzere Zeit für in Wasser instabile Chemikalien.
Portuguese: Como alternativa, pode também alterar-se o período da incubação antes da irradiação: no caso de substâncias instáveis em água, pode ser conveniente reduzir o referido período.
English: PIC FILE= "L_2000136EN.010301.EPS"]
Portuguese: PIC FILE= "L_2000136PT.010301.EPS"]
English: A PIF [ 5, predicts no phototoxic potential, whereas a PIF ] = 5 predicts phototoxic potential.
Portuguese: A obtenção de um valor PIF [ 5 traduz a ausência de potencial fototóxico, enquanto que um PIF ] = 5 traduz a existência de potencial fototóxico.
English: In such cases, a ' ] PIF' can be calculated if the (- UV) cytotoxicity test is performed up to the highest test concentration (Cmax) and this value is used for calculation of the ' ] PIF';
Portuguese: Em tais casos, pode calcular-se um valor ' ] PIF' se o ensaio de citotoxicidade (- UV) tiver decorrido até à concentração de ensaio máxima (Cmáx), valor que se utiliza no cálculo de ' ] PIF':
English: PIC FILE= "L_2000136EN.010302.EPS"]
Portuguese: PIC FILE= "L_2000136PT.010302.EPS"]
English: If only a ' ] PIF' can be obtained, then any value ] 1 predicts phototoxic potential.
Portuguese: Caso se obtenha apenas um valor ' ] PIF', qualquer valor superior a 1 traduz um potencial fototóxico.
English: In such cases, a formal 'PIF = 1' is used to characterise the result;
Portuguese: Nessas condições, utiliza-se um 'PIF = 1' teórico para caracterizar o resultado.
English: PIC FILE= "L_2000136EN.010303.EPS"]
Portuguese: PIC FILE= "L_2000136PT.010303.EPS"]
English: If only a 'PIF = 1' can be obtained, this predicts no phototoxic potential.
Portuguese: Caso se obtenha apenas um valor 'PIF = 1', o ensaio traduz a ausência de potencial fototóxico.
English: A positive result in the in vitro 3T3 NRU phototoxicity test (PIF ] = 5 or MPE ] = 0,1) indicates that the test substance has phototoxic potential.
Portuguese: A obtenção de um resultado positivo no ensaio de fototoxicidade in vitro 3T3 NRU (PIF ] = 5 ou MPE ] = 0,1) indica que a substância em estudo apresenta potencial fototóxico.
English: A negative result from the in vitro 3T3 NRU phototoxicity test (PIF [ 5 or MPE [ 0,1) indicates that the test substance was not phototoxic to the cultured mammalian cells under the conditions used.
Portuguese: A obtenção de um resultado negativo no ensaio de fototoxicidade in vitro 3T3 NRU (PIF [ 5 ou MPE [ 0,1) indica que a substância em estudo não apresenta efeitos fototóxicos nas células de mamífero cultivadas nas condições em causa.
English: PIC FILE= "L_2000136EN.010702.TIF"]"
Portuguese: PIC FILE= "L_2000136PT.010702.TIF"]"
English: ISO_1>Irritant and non-irritant materials do not reduce the TER below the threshold level.
Portuguese: ISO_1>Os materiais simplesmente irritantes e os materiais não irritantes não reduzem o TER abaixo desse limiar.
English: ERENCES
Portuguese: 4 BIBLIOGRAFIA
English: PIC FILE= "L_2000136EN.010302.EPS">
Portuguese: PIC FILE= "L_2000136PT.010302.EPS">
English: PIC FILE= "L_2000136EN.010303.EPS">
Portuguese: PIC FILE= "L_2000136PT.010303.EPS">
English: Two in vitro test for skin corrosivity, the rat skin transcutaneous electrical resistance (TER) assay and a test employing a human skin model, have been endorsed as scientifically valid by the European Centre for the Validation of Alternative Methods (ECVAM, Joint Research Centre, European Commission) .
Swedish: Europeiska centret för validering av alternativa provningsmetoder (ECVAM, Gemensamma forskningscentret, Europeiska kommissionen) har bedömt två in vitro-test för hudkorrosivitet - bestämning av transkutant elektriskt motstånd i råtthud (TER) och ett test där en modell av human hud används - som vetenskapligt validerade .
English: Furthermore, the test protocol based on a human skin model enabled correct distinction between degrees of corrosive effects (known severe skin corrosives, R35, and other skin corrosives, R34).
Swedish: Med försöksprotokollet baserat på modell av human hud kunde man dessutom framgångsrikt skilja mellan olika grader av korrosivitet (kända starkt korrosiva ämnen, R35 och andra korrosiva ämnen, R34).
English: Corrosive materials are identified by their ability to produce a loss of normal stratum corneum integrity and barrier function, which is measured as a reduction in the inherent TER below a threshold level (5 k>ISO_7>Ù) .
Swedish: Korrosiva ämnen identifieras genom sin förmåga att framkalla skador på hudens hornlager och störningar i den normala barriärfunktionen, vilket kan fastställas som en sänkning av hudens transkutana elektriska motstånd (TER) under ett tröskelvärde (5 k>ISO_7>Ù) .
English: Removal of this coating can be attempted, for example, by sealing the PTFE tube with a gloved thumb and shaking it for approximately 10 seconds; the magnesium sulphate solution is discarded and the resistance measurement is repeated with fresh magnesium sulphate.
Swedish: För att få bort ämnet kan man t.ex. sluta till PTFE-röret med tummen (som bör skyddas med handske) och skaka om röret i cirka 10 sekunder, hälla ut magnesiumsulfatlösningen och upprepa mätningen med ny magnesiumsulfatlösning.
English: If the TER values of test substances which are either surfactants or neutral organics are less than or equal to 5 k>ISO_7>Ù, >ISO_1>an assessment of dye penetration can be carried out on the tissues. This procedure will determine whether the results are false positives (2).
Swedish: Om testämnet är en surfaktant eller neutralt organiskt ämne och TER-värdet är lägre eller lika med 5 k>ISO_7ISO_1>kan falska positiva resultat sållas ut genom bestämning av färgämnespenetrationen i vävnaderna (2).
English: However, in the validation study, the TER assay was found to overestimate the corrosive potential of several test chemicals following their application to the skin discs for 2 hours, although it enabled the correct identification of corrosives and non-corrosives after a 24-hour application.
Swedish: Det visade sig dock vid valideringsstudien att TER-bestämning efter 2 timmars kemikaliepåverkan gav överdrivna resultat avseende flera kemikaliers korrosivitetspotential, trots att en korrekt identifiering av korrosiva och icke-korrosiva kemikalier kunde göras efter 24 timmars verkningstid.
English: The model must have a functional stratum corneum with an underlying layer of living cells. The barrier function of the stratum corneum must be adequate.
Swedish: Modellen måste ha ett funktionellt hornlager med ett underliggande lager levande celler och hornlagrets barriärfunktion måste vara tillräcklig.
English: Most importantly, the prediction model used must have been shown to meet the international validation standard.
Swedish: Det viktigaste kriteriet är att den förutsägbarhetsmodell som används måste ha påvisats uppfylla internationella valideringsstandarder.
English: The application method must be shown to be adequate for a wide range of chemical types.
Swedish: Appliceringsmetoden måste bevisligen vara lämplig för ett stort antal olika kemikalietyper.
English: The most frequently used assay is MTT reduction, which has been shown to give accurate and reproducible results in various laboratories.
Swedish: Den oftast använda bestämningsmetoden är MTT-reduktion, som har visat sig ge exakta och reproducerbara resultat i olika laboratorier.
English: It is recommended that the methodology and prediction model are calibrated by testing a series of reference standards chosen from the chemicals used in the ECVAM validation study.
Swedish: Det rekommenderas att metoden och förutsägbarhetsmodellen kalibreras genom testning av en serie referensstandarder som väljs ut bland de kemikalier som användes i ECVAM-valideringsstudien.
English: As a minimum, the method should meet the criteria for scientific validity defined previously, and the results of such a validation study must be published in a peer-reviewed scientific journal.
Swedish: Metoden bör minst uppfylla de fastställda kriterierna för vetenskaplig validitet och resultaten från en sådan valideringsstudie måste publiceras i en kollegialt granskad vetenskaplig tidskrift.
English: In 1996 an OECD workshop recommended an in vitro tier testing approach for phototoxicity assessment.
Swedish: Ett OECD-arbetsmöte lämnade 1996 rekommendationer om en sekventiell in vitro-testmetod för bedömning av fototoxicitet.
English: Photoirritation: a sub-species of the term 'phototoxicity', which is used to describe only those phototoxic reactions which are produced at the skin after exposure to chemicals (topically or orally). These photoxic reactions lead always to non-specific cell damage (sunburn like reactions).
Swedish: Fotoirritation: Ett underbegrepp av termen 'fototoxicitet'. Begreppet används endast för att beskriva sådana fototoxiska reaktioner som uppstår i huden efter kemikalieexponering (på huden eller oralt) och som alltid leder till icke-specifika cellskador (reaktioner av typen solbrännskador).
English: Many types of chemicals have been reported to induce phototoxic effects.
Swedish: Många typer av kemikalier har rapporterats orsaka fototoxiska verkningar .
English: Four mechanisms have been identified by which absorption of light by a (chemical) chromophore can result in a phototoxic response.
Swedish: Man har identifierat fyra mekanismer som kan resultera i fototoxisk respons genom att ljus absorberas av en (kemisk) kromofor .
English: An example of the spectral irradiance distribution of the filtered solar simulator used in the validation study of the in vitro 3T3 NRU phototoxicity test has been published.
Swedish: Man har offentliggjort ett exempel på den spektrala strålningsdistributionen från den filtrerade solsimulator som användes i valideringsstudien för 3T3 NRU-fototoxicitetstestet in vitro.
English: The maximum concentration of a test chemical should not exceed 100 µg/ml, since all phototoxic chemicals were detected at lower concentrations, whereas at higher concentrations the incidence of false positives (overpredictions) increases .
Swedish: Testkemikaliens maximikoncentration får inte överskrida 100 µg/ml, eftersom alla fototoxiska kemikalier detekterades vid lägre koncentrationer. Vid högre koncentrationer ökar återigen förekomsten av falska positiva utslag.
English: This can be done by applying any appropriate non-linear regression procedure (preferably a Hill function or logistic regression) to the concentration-response data, or by using other fitting procedures.
Swedish: Detta kan genomföras med hjälp av valfri icke-linjär regressionsprocedur (helst en Hill-funktion eller logistisk regressionsanalys) för koncentrations-responsdata, eller med hjälp av andra anpassningsprocedurer.
English: Done at Brussels, 25 April 2000. For the Commission
Polish: Sporządzono w Brukseli, dnia 25 kwietnia 2000 r.
Hungarian: Kelt Brüsszelben, 2000. április 25-én.
English: Furthermore, the test protocol based on a human skin model enabled correct distinction between degrees of corrosive effects (known severe skin corrosives, R35, and other skin corrosives, R34) (2). Description and procedures for both tests are given;
Polish: Ponadto, protokół badania wykorzystującego model skóry ludzkiej umożliwiał prawidłowe rozróżnienie między siłą działania środków powodujących uszkodzenie (zwanych jako środki powodujące silną korozję skóry, R35, i inne środki powodujące korozję skóry, R34) (2).
English: The databridge electrodes are placed on either side of the skin disc to take the resistance measurement in k/ skin disc (Figure 2).
Polish: Elektrody pomiarowe mostka należy przyłożyć po obu stronach krążka skóry w celu zmierzenia oporności krążka w k/krążek skóry (rysunek 2).
English: Note that if the measured resistance value is greater than 20 k this may be due to the test substance coating the epidermal surface of the sking disc.
Czech: Je třeba si všimnout, že je-li naměřená hodnota vyšší než 20 k, může to být způsobeno vrstvou zkoušené látky na epidermální straně terčíku kůže.
Polish: Należy zauważyć, że jeżeli zmierzona oporność jest większa niż 20 k, przyczyną mogą być pozostałości badanej substancji zakrywające powierzchnię naskórka krążka skóry.
Estonian: Tuleb märkida, et kui mõõdetud takistuse väärtus on üle 20 k, siis võib see olla tingitud nahaketta epidermisel oleva uuritava aine kattekihist.
English: If the TER values of test substances which are either surfactants or neutral organics are less than or equal to 5 k an assessment of dye penetration can be carried out on the tissues.
Czech: Jsou-li hodnoty TER pro povrchově aktivní látky nebo organické látky jakožto zkoušené látky menší nebo rovny 5 k, lze provést na tkáni stanovení průniku barviva.
Polish: Jeżeli zmierzone wartości TER dla badanych substancji powierzchniowo czynnych i obojętnych substancji organicznych są mniejsze lub równe 5 k, można dla tych tkanek wykonać ocenę głębokości penetracji barwnika.
Estonian: Kui uuritavateks aineteks on pindaktiivsed ained või neutraalsed orgaanilised ühendid ja TERi määratud väärtused on väiksemad või võrdsed 5 k, siis tuleb hinnata värvainete sissetungi ulatust kudedes.
English: If the mean TER value obtained for the test substance is greater than 5 k then it is non-corrosive.
Czech: Je-li hodnota TER dosažená pro zkoušenou látku větší než 5 k, není látka žíravá.
Polish: Jeżeli wartość średnia TER uzyskana dla badanej substancji jest większa niż 5 k, substancja ta jest niekorozyjna.
Estonian: Kui uuritava aine korral on mõõdetud TERi keskmine väärtus üle 5 k, siis on see aine mittesöövitav.
English: If the TER value is less than or equal to 5 k and the test substance is not a surfactant or neutral organic, then it is corrosive.
Czech: Je-li hodnota TER menší nebo rovna 5 k a nejde o povrchově aktivní látku nebo neutrální organickou látku, je látka žíravá.
Polish: Jeżeli wartość TER jest mniejsza lub równa 5 k, a badana substancja nie jest środkiem powierzchniowo czynnym ani obojętną substancją organiczną, to jest ona korozyjna.
Estonian: Kui TERi väärtus on väiksem kui 5 k või sellega võrdne ning uuritav aine ei ole pindaktiivne või neutraalne orgaaniline ühend, siis on tegemist söövitava ainega.
English: For surfactants or neutral organics which give TER values less than or equal to 5 k dye penetration can be carried out.
Czech: U povrchově aktivních látek nebo neutrálních organických látek, které dávají hodnoty TER menší nebo rovné 5 k, lze provést stanovení průniku barviva.
Polish: W przypadku środków powierzchniowo czynnych i obojętnych substancji organicznych, dla których wartości TER są mniejsze lub równe 5 k, można przeprowadzić próbę penetracji barwnika.
Estonian: Pindaktiivsete ainete või neutraalsete orgaaniliste ühendite korral, kui TERi määratud väärtused on väiksemad või võrdsed 5 k, võib läbi viia värvaine imendumise katse.