FrancophonIA/DGT-Translation_Memory huggingface dataset:
English: Acad. Sci. USA, 61, pp. 1306-1312.
Italian: Acad. Sci. USA, 61, pp. 1306-1312.
English: Applegate, M. L., Moore, M. M., Broder, C. B., Burrell, A. and Hozier, J. C. (1990), Molecular Dissection of Mutations at the Heterozygous Thymidine Kinase Locus in Mouse Lymphoma Cells, Proc. Natl.
Italian: Applegate, M. L., Moore, M. M., Broder, C. B., Burrell, A. and Hozier, J. C. (1990), Molecular Dissection of Mutations at the Heterozygous Thymidine Kinase Locus in Mouse Lymphoma Cells, Proc. Natl.
English: Acad. Sci. USA, 87, pp. 51-55.
Italian: Acad. Sci. USA, 87, pp. 51-55.
English: Prior to sacrifice, animals are treated with a metaphase-arresting substance (e.g. colchicine or Colcemid®). Chromosome preparations are then made from germ cells and stained, and metaphase cells are analysed for chromosome aberrations.
Italian: Sono poi approntate e sottoposte a un processo di colorazione preparazioni cromosomiche provenienti dalle cellule germinali, e se ne analizzano le cellule in metafase per determinare le aberrazioni cromosomiche.
Lithuanian: Prieš numarinimą gyvūnai paveikiami agentu, sustabdančiu ląstelių dalijimąsi metafazėje (pavyzdžiui, kolchicinu arba Kolcemidu©).Iš gemalinių ląstelių išskiriamos chromosomos, jos dažomos ir metafazėje esančios ląstelės tiriamos mikroskopu, kad būtų nustatytos chromosomų aberacijos.
English: If there is toxicity, three dose levels are used for the first sampling time. These dose levels should cover a range from the maximum to little or no toxicity.
Italian: In caso di tossicità si usino per la prima fase di campionamento tre dosi diverse, che vadano dalla tossicità massima ad una tossicità assente o modica.
Portuguese: Se a substância for tóxica, deverão ser utilizadas três doses diferentes para a primeira amostragem, abrangendo uma gama compreendida entre a toxicidade máxima e uma toxicidade reduzida ou quase nula.
Polish: Jeżeli istnieje toksyczność, trzy poziomy dawek są wykorzystywane w odniesieniu do pierwszego okresu pobierania próbek Te poziomy dawek powinny objąć zakres od najwyższej do niskiej toksyczności lub do jej braku.
English: DATA 2.1. TREATMENT OF RESULTS
Italian: RISULTATI 2.1. TRATTAMENTO DEI RISULTATI
English: Results: - signs of toxicity, - mitotic index,
Italian: Risultati: - segni di tossicità; - coefficiente mitotico;
English: PROCEDURE 1.5.1. Number and sex of animals
Italian: PROCEDURA 1.5.1. Numero e sesso degli animali
English: Dose levels Normally, at least two dose levels are used.
Italian: Dosi Di norma si usano almeno due dosi.
English: The slide preparations should contain sufficient cells of normal morphology to permit a meaningful assessment of UDS. Preparations are examined microscopically for signs of overt cytoxicity (e.g. pyknosis, reduced levels of radiolabelling).
Italian: I preparati su vetrino devono contenere cellule di morfologia normale in numero sufficiente per permettere una valutazione probante dell'UDS. I preparati sono esaminati al microscopio alla ricerca di segni evidenti di citotossicità (p. es. picnosi, livelli ridotti di radiomarcatura).
English: Slides should be coded before grain counting. Normally 100 cells are scored from each animal from at least two slides;
Italian: Si codifichino i vetrini prima del conteggio dei grani. Di norma si analizzano 100 cellule per animale, su almeno due vetrini.
English: Test animals: - species/strain used,
Italian: Animali da laboratorio: - specie/ceppo usato;
Hungarian: Kísérleti állatok: - használt fajok/törzs,
English: statistical evaluation if any, - signs of toxicity,
Italian: eventuali analisi statistiche; - segni di tossicità;
English: number of S-phase cells if determined, - viability of the cells.
Italian: numero di cellule in fase S, se determinato; - vitalità delle cellule.
English: Farligt R65 Farligt: kan ge lungskador vid förtäring.
Italian: Nocivo R65 Farligt: kan ge lungskador vid förtäring.
English: (Does not concern the ES version) (Does not concern the DA version) (Does not concern the DE version) (Does not concern the EL version) (Does not concern the EN version) (Does not concern the FR version) (Does not concern the IT version)
Italian: (Non riguarda la versione ES) (Non riguarda la versione DA) (Non riguarda la versione DE) (Non riguarda la versione EL) (Non riguarda la versione EN) (Non riguarda la versione FR) (Non riguarda la versione IT)
English: (Does not concern the NL version) (Does not concern the PT version) (Does not concern the FI version)
Italian: (Non riguarda la versione NL) (Non riguarda la versione PT) (Non riguarda la versione FI)
English: (Does not concern the ES version) (Does not concern the DA version) (Does not concern the DE version) (Does not concern the EL version) (Does not concern the EN version) (Does not concern the FR version)
Italian: (Non riguarda la versione ES) (Non riguarda la versione DA) (Non riguarda la versione DE) (Non riguarda la versione EL) (Non riguarda la versione EN) (Non riguarda la versione FR)
English: (Does not concern the IT version) (Does not concern the NL version) (Does not concern the PT version) (Does not concern the SV version)
Italian: (Non riguarda la versione IT) (Non riguarda la versione NL) (Non riguarda la versione PT) (Non riguarda la versione SV)
English: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
Spanish: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
Italian: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
Dutch: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
Finnish: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
Polish: S 28 Bei Berührung mit der Haut sofort mit viel... abwaschen (vom Hersteller anzugeben)
English: S 29 Ei saa tyhjentää viemäriin
Spanish: S 29 Ei saa tyhjentää viemäriin
Italian: S 29 Ei saa tyhjentää viemäriin
Dutch: S 29 Ei saa tyhjentää viemäriin
Finnish: S 29 Ei saa tyhjentää viemäriin
Slovak: S 29 Ei saa tyhjentää viemäriin
Polish: S 29 Ei saa tyhjentää viemäriin
English: ANNEX 6 " ANNEX IX
Italian: ALLEGATO 6 " ALLEGATO IX
English: PART B Provisions relating to tactile warning devices
Italian: PARTE B Dispositivi che permettono di rilevare i pericoli al tatto
Polish: CZĘŚĆ B Przepisy odnoszące się do urządzeń pozwalających na dokonanie identyfikacji, działających w oparciu o bodźce dotykowe
English: Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M. Jr., Brusick, D., Ashby, J. and Myhr, B. C. (1991), Genotoxicity under Extreme Culture Conditions. A report from ICPEMC Task Group 9, Mutation Res., 257, pp. 147-204.
Dutch: Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M.Jr., Brusick, D., Ashby, J. and Myhr, B.C. (1991). Genotoxicity under Extreme Culture Conditions. A report from ICPEMC Task Group 9. Mutation Res., 257, pp. 147-204.
English: Elliot, B. M., Combes, R. D., Elcombe, C. R., Gatehouse, D. G., Gibson, G. G., Mackay, J. M. and Wolf, R. C. (1992), Report of UK Environmental Mutagen Society Working Party. Alternative to Aroclor 1254-induced S9 in In Vitro Genotoxicity Assays, Mutagenesis, 7, pp. 175-177.
Dutch: Elliot, B.M., Combes, R.D., Elcombe, C.R., Gatehouse, D.G., Gibson, G.G., Mackay, J.M. and Wolf, R.C. (1992). Report of UK Environmental Mutagen Society Working Party. Alternatives to Aroclor 1254-induced S9 in In Vitro Genotoxicity Assays. Mutagenesis, 7, pp. 175-177.
English: Richold, M., Chandley, A., Ashby, J., Gatehouse, D. G., Bootman, J. and Henderson, L. (1990), In vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report, Part I revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141.
Dutch: Richold, M., Chandley, A., Ashby, J., Gatehouse, D.G., Bootman, J. and Henderson, L. (1990). In Vivo Cytogenetic Assays. In: D.J. Kirkland (Ed.) Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report. Part I revised. Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141.
English: Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: UKEMS Sub-Committee on Guidelines for Mutagenicity Testing, Report Part III. Statistical Evaluation of Mutagenicity Test Data, D. J. Kirkland (ed.) Cambridge University Press, Cambridge, pp. 184-232.
Dutch: Lovell, D.P., Anderson, D., Albanese, R., Amphlett, G.E., Clare, G., Ferguson, R., Richold, M., Papworth, D.G. and Savage, J.R.K. (1989). Statistical Analysis of In Vivo Cytogenetic Assays. In: UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report Part. III. Statistical Evaluation of Mutagenicity Test Data. D.J. Kirkland, (Ed.) Cambridge University Press, Cambridge. pp. 184-232.
English: Bone marrow cells are usually obtained from the femurs or tibias immediately following sacrifice. Commonly, cells are removed from femurs or tibias, prepared and stained using established methods.
Dutch: De beenmergcellen worden meestal volgens gangbare methoden uit het dijbeen of scheenbeen van pas gedode dieren verwijderd, geprepareerd en gekleurd.
English: Mavournin, K. H., Blakey, D. H., Cimino, M. C., Salamone, M. F. and Heddle, J. A. (1990), The In Vivo Micronucleus Assay in Mammalian Bone Marrow and Peripheral Blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 239, pp. 29-80.
Dutch: Mavournin, K.H., Blakey, D.H., Cimino, M.C., Salamone, M.F. and Heddle, J.A. (1990). The In Vivo Micronucleus Assay in Mammalian Bone Marrow and Peripheral Blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 239, pp. 29-80.
English: Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Staticical Analysis of In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Statistical Evaluation of Mutagenicity Test Data. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report, Part III, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
Portuguese: Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Statistical Evaluation of Mutagenicity Test Data. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report, Part III, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
Dutch: Lovell, D.P., Anderson, D., Albanese, R., Amphlett, G.E., Clare, G., Ferguson, R., Richold, M., Papworth, D.G. and Savage, J.R.K. (1989). Statistical Analysis of In Vivo Cytogenetic Assays. In: D.J. Kirkland (Ed.) Statistical Evaluation of Mutagenicity Test Data. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report, Part III. Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
English: Zeiger, E., Anderson, B. E., Haworth, S., Lawlor, T. and Mortelmans, K. (1992), Salmonella Mutagenicity Tests. V. Results from the Testing of 311 Chemicals, Environ. Mol. Mutagen., 19, pp. 2-141.
Portuguese: Zeiger, E., Anderson B. E., Haworth, S., Lawlor, T. and Mortelmans, K. (1992), Salmonella Mutagenicity Tests. V. Results from the Testing of 311 Chemicals, Environ. Mol. Mutagen., 19, pp. 2-141.
Dutch: Zeiger, E., Anderson, B.E., Haworth, S., Lawlor, T. and Mortelmans, K. (1992). Salmonella Mutagenicity Tests. V. Results from the Testing of 311 Chemicals. Environ. Mol. Mutagen., 19, pp. 2-141.
Polish: Zeiger, E., Anderson, B. E., Haworth, S., Lawlor, T. and Mortelmans, K. (1992), Salmonella Mutagenicity Tests. V. Results from the Testing of 311 Chemicals, Environ. Mol. Mutagen., 19, pp. 2-141.
English: Relative total growth: increase in cell number over time compared to a control population of cells; calculated as the product of suspension growth relative to the negative control times cloning efficiency relative to negative control.
Dutch: Relatieve totale groei: de toename van het aantal cellen in de loop van de tijd in vergelijking met een controle-celpopulatie, berekend als het product van de suspensiegroei in vergelijking met de negatieve controle en de kloneringsefficiëntie in vergelijking met de negatieve controle.
Swedish: relativ total tillväxt: ökningen av antalet celler över tiden jämfört med en kontrollpopulation av celler, beräknat som produkten av suspensionstillväxten i förhållande till den negativa kontrollen, gånger kloningseffektiviteten i förhållande till den negativa kontrollen.
Latvian: Relatīvais kopējais pieaugums: šūnu skaita palielināšanās laikā salīdzinājumā ar šūnu kontroles populāciju, ko aprēķina, reizinot suspensijas pieauguma attiecību pret negatīvo kontroli ar klonēšanas efektivitātes attiecību pret negatīvo kontroli.
English: It may be useful to assess solubility at the beginning and the end of the treatment, as solubility can change during the course of exposure in the test system due to presence of cells, S9, serum etc.
German: Möglicherweise ist es sinnvoll, die Löslichkeit zum Anfang und Abschluß der Behandlung zu bewerten, da sich die Löslichkeit im Versuchssystem während der Exposition aufgrund des Vorhandenseins von Zellen, S9, Serum usw. verändern kann.
Dutch: Het kan nuttig zijn de oplosbaarheid aan het begin en het eind van de behandeling te bepalen, aangezien de oplosbaarheid tijdens de blootstelling in het testsysteem door de aanwezigheid van bijvoorbeeld cellen, S9 of serum kan veranderen.
Swedish: Det kan vara lämpligt att fastställa lösligheten vid behandlingens början och slutpunkt, eftersom lösligheten kan förändras under exponeringsförloppet i testsystemet beroende på närvaron av celler, S9, serum, etc.
Hungarian: Hasznosnak bizonyulhat az oldékonyság értékelése a kezelés kezdetén és végén, mivel az oldékonyság változhat a vizsgálati rendszerben az expozíció során a sejtek, S9, és a szérum stb. jelenléte miatt.
Romanian: Ar putea fi utilă evaluarea solubilității la începutul și la sfârșitul tratamentului, deoarece solubilitatea poate să varieze în timpul expunerii în sistemul de testare datorită prezenței celulelor, S9, serului etc.
Bulgarian: Може да бъде да се определи разтворимостта в началото и края на третирането, тъй като тя може да се промени в течение на експонирането в тестваната система поради присъствието на клетки, S9, серум и др.
Estonian: On kasulik hinnata lahustuvust töötlemise alguses ja lõpus, kuna katsesüsteemis võib lahustuvus töötlemise ajal muutuda rakkude, S9-seerumi jms mõjul.
Lithuanian: Prieš pradedant ir baigiant veikimą tiriamąja medžiaga, būtų naudinga nustatyti tirpumą, kadangi veikimo metu tirpumas gali pakisti dėl tiriamojoje sistemoje esančių ląstelių, S9 mišinio, serumo ir pan.
English: Aaron, C.S., Bolcsfoldi, G., Glatt, H.R., Moore, M., Nishi, Y., Stankowski, Jr. L.F., Theiss, J. and Thompson, E. (1994), Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res. 312, pp. 235-239.
Portuguese: Aaron, C. S., Bolcsfoldi, G., Glatt, H. R., Moore, M., Nishi, Y., Stankowski, Jr. L. F., Theiss, J. and Thompson, E. (1994), Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res., 312, pp. 235-239.
Dutch: Aaron, C.S., Bolcsfoldi, G., Glatt, H.R., Moore, M., Nishi, Y., Stankowski, Jr.L.F., Theiss, J. and Thompson, E. (1994). Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res., 312, pp. 235-239.
English: Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M., Brusick, D., Ashby, J. and Myhr, B.C. (1991), Genotoxicity Under Extreme Culture Conditions. A report from ICPEMC Task Group 9, Mutation Res. 257, pp. 147-204.
Dutch: Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M., Brusick, D., Ashby, J. and Myhr, B.C. (1991). Genotoxicity Under Extreme Culture Conditions. A report from ICPEMC Task Group 9. Mutation Res., 257, pp. 147-204.
English: Clive, D., McCuen, R., Spector, J. F. S., Piper, C. and Mavournin, K. H. (1983), Specific Gene Mutations in L5178Y Cells in Culture. A Report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 115, pp. 225-251.
Dutch: Clive, D., McCuen, R., Spector, J. F. S., Piper, C. and Mavournin, K. H. (1983), Specific Gene Mutations in L5178Y Cells in Culture. A Report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 115, pp. 225-251.
English: Richold, M., Ashby, J., Chandley, A., Gatehouse, D. G. and Henderson, L. (1990), In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing. Report. Part I revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141.
Dutch: Richold, M., Ashby, J., Chandley, A., Gatehouse, D.G. and Henderson, L. (1990), In Vivo Cytogenetic Assays. In: D.J. Kirkland (ed.), Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing. Report. Part I revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141.
English: Adler, I. D., Shelby M. D., Bootman, J., Favor, J., Generoso, W., Pacchierotti, F., Shibuya, T. and Tanaka N. (1994), International Workshop on Standardisation of Genotoxicity Test Procedures. Summary Report of the Working Group on Mammalian Germ Cell Tests, Mutation Res., 312, pp. 313-318.
Dutch: Adler, I.D., Shelby M.D., Bootman, J., Favor, J., Generoso, W., Pacchierotti, F., Shibuya, T. and Tanaka N. (1994). International Workshop on Standardisation of Genotoxicity Test Procedures. Summary Report of the Working Group on Mammalian Germ Cell Tests. Mutation Res., 312, pp. 313-318.
English: Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clarc, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Statistical Evaluation of Mutagenicity Test Data. UKEMS Subcommittee on Guidelines for Mutagenicity Testing, report, Part III. Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
Portuguese: Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.) , Statistical Evaluation of Mutagenicity Test Data. UKEMS Subcommittee on Guidelines for Mutagenicity Testing, report, Part III, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
Dutch: Lovell, D.P., Anderson, D., Albanese, R., Amphlett, G.E., Clarc, G., Ferguson, R., Richold, M., Papworth, D.G. and Savage J.R.K. (1989). Statistical Analysis of In Vivo Cytogenetic Assays. In: D.J. Kirkland (ed.), Statistical Evaluation of Mutagenicity Test Data. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing, report, Part III. Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232."
English: Kennelly, J. C., Waters, R., Ashby, J., Lefevre, P. A., Burlinson, B., Benford, D. J., Dean, S. W. and Mitchell, I. de G. (1993), In Vivo Rat Liver UDS Assay, in: Kirkland D. J. and Fox M., (eds), Supplementary Mutagenicity Tests: UKEM Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing. Report. Part II revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 52-77.
Portuguese: Kennelly, J. C., Waters, R., Ashby, J., Lefevre, P. A., Burlinson B., Benford, D. J., Dean, S. W. and Mitchell I. de G. (1993), In Vivo Rat Liver UDS Assay, in: Kirkland D. J. and Fox M., (eds.) , Supplementary Mutagenicity Tests: UKEM Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing Report. Part II revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 52-77.
Dutch: Kennelly, J.C., Waters, R., Ashby, J., Lefevre, P.A., Burlinson, B., Benford, D.J., Dean, S.W. and Mitchell, I. de G. (1993), In Vivo Rat Liver UDS Assay. In: Kirkland D.J. and Fox M., (eds), Supplementary Mutagenicity Tests: UKEM Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing. Report. Part II revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 52-77.
English: (Doesnot concern the PT version)
Portuguese: (Versão PT não afectada)
English: This metabolic activation system cannot mimic entirely the mammalian in vivo conditions. Care should be taken to avoid conditions which would lead to positive results which do not reflect intrinsic mutagenicity and may arise from changes in pH, osmolality or high levels of cytotoxicity (4) (5).
Portuguese: Deve ter-se o cuidado de evitar condições que conduzam a resultados positivos que não sejam reflexo de uma mutagenicidade intrínseca mas que possam resultar, por exemplo, de mudanças do pH, da pressão osmótica ou ainda de níveis elevados de citotoxicidade (4) (5).
English: Mitotic index: the ratio of cells in metaphase divided by the total number of cells observed in a population of cells; an indication of the degree of proliferation of that population.
Portuguese: Índice mitótico: relação entre o número de células em metafase e o número total de células observadas numa população de células, que fornece uma indicação do grau de proliferação da população em causa.
English: Each cell culture is harvested and processed separately for the preparation of chromosomes. Chromosome preparation involves hypotonic treatment of the cells, fixation and staining.
Portuguese: Procede-se à colheita individual das culturas e ao respectivo processamento, com vista à preparação dos cromossomas, que inclui o tratamento hipotónico das células, seguido de fixação e coloração.
English: Although most experiments will give clearly positive or negative results, in rare cases the data set will preclude making a definite judgement about the activity of the test substance. Results may remain equivocal or questionable regardless of the number of times the experiment is repeated.
Portuguese: Embora a maioria de experiências tenha resultados claramente positivos ou negativos, em casos raros o conjunto dos dados não permitirá que se obtenha uma opinião inequívoca sobre a actividade da substância em estudo, podendo acontecer que os resultados continuem a ser ambíguos ou duvidosos independentemente do número de vezes que a experiência seja repetida.
English: At the later sampling time only the highest dose needs to be used. The highest dose is defined as the dose-producing signs of toxicity such that higher dose levels, based on the same dosing regimen, would be expected to produce lethality.
Portuguese: Na segunda amostragem só será necessário avaliar a dose máxima, que é definida como a dose que produz sinais de toxicidade tais que indiquem que a utilização de doses superiores, com o mesmo regime de administração, produzirá mortalidade.
English: Although most experiments will give clearly positive or negative results, in rare cases the data set will preclude making a definite judgement about the activity of the test substance. Results may remain equivocal or questionable regardless of the number of experiments performed.
Portuguese: Embora a maioria de experiências tenha resultados claramente positivos ou negativos, em casos raros o conjunto dos dados não permitirá que se obtenha uma opinião inequívoca sobre a actividade da substância em estudo, podendo acontecer que os resultados continuem a ser ambíguos ou duvidosos independentemente do número de vezes que a experiência seja repetida.