Extract from the text the main characteristics of the city of São Paulo. Separate them with a comma.

most populous city in Brazil, most populous and wealthiest Brazilian state, located in the country's Southeast Region, Listed by the GaWC as an alpha global city, the most populous city proper in the Americas, the world's 4th largest city proper by population, São Paulo is the largest Portuguese-speaking city in the world, city's name honors the Apostle, Saint Paul of Tarsus, ranks as the most populous in Brazil and the 12th most populous on Earth