Before revision:  These result make it possible to , for the first time, construct a unified, consistent objective function for the parameterization of Markov state models for protein dynamics which captures the tradeoff between systematic and statistical errors.
After revision:  These result make it possible to , for the first time, construct a unified, consistent objective function for the parameterization of Markov state models for protein dynamics in a way that appropriately captures the tradeoff between systematic and statistical errors.