Before revision:  Through comparison with published experimental results we demonstrate the importance of appropriately representing IP3R gating, verify that our model is capable of reproducing known disease phenotypes in the calcium transient through alteration of channel proportions , and examine how sensitive the cardiac cell is to IP3.
After revision:  Through comparison with published experimental results we demonstrate the importance of appropriately representing IP3R gating, verify that our model is capable of reproducing known disease phenotypes in the calcium transient through alteration of channel properties , and examine how sensitive the cardiac cell is to IP3.