Before revision:  To do so, we have incorporated the kinetics and energetics of memory response as ingredients of non-equilibrium decision-making between an adaptive exploration to mount a specific and novel response or exploitation of existing memory that can be activated rapidly yet with a reduced specificity against evolved pathogens. To achieve a long-term benefit for the host, we show that memory generation should be actively regulated and dependent on immune receptors ' affinity, with a preference for cross-reactive receptors with a moderate affinity against pathogens as opposed to high affinity receptors -
After revision:  We show that memory generation should be actively regulated and dependent on immune receptors ' affinity, with a preference for cross-reactive receptors with a moderate affinity against pathogens as opposed to high affinity receptors -