Before revision:  A major limitation of previous studies using single infection data is that they have produced discrepant estimates of these quantities. This evaluation demonstrates that sequential infection experiments provide richer information for quantifying the contribution of each immune component to cross-protection. This information enhances our understanding of the mechanisms underlying the control and resolution of infection, and generates new insight into how previous exposure influences the time course of a subsequent infection.
After revision:  A major limitation of previous studies using single infection data cannot be used to reliably recover this information. Hence, sequential infection data enhances our understanding of the mechanisms underlying the control and resolution of infection, and generates new insight into how previous exposure influences the time course of a subsequent infection.