Before revision: In this paper we propose that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome 'self-injury') that involves cutting and releasing single-strand DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome.
After revision: In this paper we propose that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome 'self-injury') that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome.