Before revision:  Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction (30\%-50\%) of MCI individuals will progress to dementia . Even when a prognosis of dementia is established using machine learning models and biomarkers, the fraction of MCI progressors remain limited (50\%-75\%). Instead of aiming at precise diagnosis in large clinical cohorts known for their heterogeneity, we propose here to identify only a subset of individuals who share a common brain signature highly predictive of oncoming dementia.
After revision:  Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction (30\%-50\%) of MCI individuals will progress to dementia , even when screened using biomarkers. We propose here to identify only a subset of individuals who share a common brain signature highly predictive of oncoming dementia.