Before revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation , and decreasing methylation in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors for pluripotency. Therefore, miRNAs systematically repress development and inhibit the epigenetic system to dynamically modulate stem cell pluripotency .
After revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation , and decreasing methylation in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors , creating an active circuit system to modulate pluripotency. MiRNAs vary their functions with different stem cell states. While miRNAs directly repress pluripotent core factors to facilitate the differentiation during cell differentiation, they also help stem cells to maintain pluripotency by activating pluripotent cores through directly repressing DNA methylation systems and primarily inhibiting development .