Before revision: Motivation In many key applications in the field of metabolomics, such as toxicology or nutrigenomics, it is of interest to profile and detect physiological changes in metabolic pathways .
After revision: Motivation In many key applications in the field of metabolomics, such as toxicology or nutrigenomics, it is of interest to profile and detect physiological changes in metabolic processes, usually represented in the form of pathways. As an alternative, a broader point of view would enable investigators to better understand the relations between entities that exist in different processes. Therefore, relating a possible perturbation to several known processes represents a new approach to this field of study. We propose to use a network representation of metabolism in terms of reactants, enzyme and metabolite .