Before revision: Various data suggest that the brain carries out probabilistic inference. Models that perform inference through sampling are particularly appealing since instead of requiring networks to perform sophisticated mathematical operations, they can simply exploit stochasticity in neuron behavior. However, sampling from complex distributions is a hard problem. In particular, mixing behavior is often very sensitive to the temperature parameter which controls the stochasticity of the sampler .
After revision: Being permanently confronted with an uncertain world, brains have faced evolutionary pressure to represent this uncertainty in order to respond appropriately. Often, this requires visiting multiple interpretations of the available information or multiple solutions to an encountered problem. This gives rise to the so-called mixing problem: since all of these "valid" states represent powerful attractors, but between themselves can be very dissimilar, switching between such states can be difficult .