Before revision:  With this model , many unique properties and behaviors of ion channels can be explained, including the real physical working mechanism of optogenetics, the refractory period in activation of action potential, the stochastic gating pattern of single ion channel and the nerve conductance block . Meanwhile, this model is consistent with our previous C-P theory. In this study, the probability calculus equation is amended and expanded to a more general scenario, thus called a general probability for differentiation with the probability calculus in C-P theory.
After revision:  With this model , many unique properties and behaviors of ion channels can be explained, including the real physical working mechanism of optogenetics, the refractory period in activation of action potential, the stochastic gating pattern of single ion channel , the difference between electrical and optical stimulation (optogenetics), nerve conduction block and the generation of an action potential, become intrinsic features of this physical model. Moreover, this model also provides a foundation for the probability equation used to calculate the results of electrical stimulation in our previous C-P theory.