Before revision: Research of homogeneous ( i.e., single node and edge type) biological networks (BNs) has received significant attention. Graphlets have been proven in homogeneousBN research.Given their popularity, graphlets were extended to their directed or dynamic counterparts, owing to increase in availability of directed or temporal BNs. Given the increasing amounts of available BN data of different types, we generalize current homogeneous graphlets to their heterogeneous counterparts, which encompass different node or edge types and thus allow for analyzing a heterogeneous "network of networks".
After revision: Research of homogeneous ( i.e., conserved) network regions. Existing NA methods are homogeneous, i.e., they can deal only with networks containing nodes and edges of one type. However, due to increasing amounts of available BN data of different types, we generalize current homogeneous graphlets to their heterogeneous counterparts, which encompass different node or edge types and thus allow for analyzing a heterogeneous "network of networks".