Before revision: Here we propose an objective scheme to quantify the precise amount of negative entropy, present in an extremely important biochemical pathway; namely, the TCA cycle. Our approach is based on the computational implementation of two-person non-cooperative finite zero-sum game between positive entropy and negative entropy .
After revision: Biological systems possess negative entropy. In them, one form of order produces another, URLanized form of order. We propose a formal scheme to calculate robustness of an entire biological system by quantifying the negative entropy present in it. Our Methodology is based upon a computational implementation of two-person non-cooperative finite zero-sum game between positive entropy and negative entropy .