Before revision:  Preventing hyperinflammation is key to avoiding progression to severe stages of COVID-19. We have previously demonstrated that alpha-1 adrenergic receptor (\alpha_1-AR) antagonists can prevent cytokine storm syndrome and resulting death in mice.
After revision:  Preventing hyperinflammation is key to avoiding these outcomes. We previously demonstrated that alpha-1 adrenergic receptor (\alpha_1-AR) antagonists can prevent cytokine storm syndrome and resulting death in mice.