Before revision:  Importantly, among the different virtual hits, we identified mefloquine, a quinoline-derivative belonging to a class of antimalaria agents (e.g. chloroquine and hydroxychloroquine) recently described for their effects on ACE2 maturation. Thus, our results suggest that these drugs could act against SARS-CoV-2 by altering the folding pathway of its receptor ACE2  .
After revision:  Importantly, among the different virtual hits, we identified mefloquine, a quinoline-derivative belonging to a class of antimalaria agents (e.g. chloroquine and hydroxychloroquine) recently described for their effects on ACE2 expression in Vero cells in a dose-dependent fashion. Importantly, these molecules potently inhibited the entry into cells of a pseudotyped retrovirus exposing the SARS-CoV-2 spike protein. Our results indicate that these drugs could act against SARS-CoV-2 by altering the folding pathway of its receptor ACE2 .