Before revision:  The resulting net motion is known to be bidirectional , but the mechanism of switching remains unclear. In this work , we propose a mean-field mathematical model of the mechanical interactions of two populations of molecular motors with diffusion of the cargo (thermal fluctuations ) as the fundamental noise source.
After revision:  The resulting net motion is known to be bidirectional , but the mechanism of switching remains subtle. Although previous work focuses on the motor number as the driving noise source for switching, this work proposes an alternative possibility: cargo diffusion. A mean-field mathematical model of the mechanical interactions of two populations of molecular motors with diffusion of the cargo (thermal fluctuations ) as the fundamental noise source.