Before revision:  In this paper, we show that molecular IFCs  suffer from a hazardous instability called negative-equilibrium catastrophe (NEC), whereby all nonnegative equilibria vanish under the action of the controllers, and some of the underlying molecular abundances blow up.
After revision:  In this paper, we show that molecular IFCs can suffer from a hazardous instability called negative-equilibrium catastrophe (NEC), whereby all nonnegative equilibria vanish under the action of the controllers, and some of the underlying molecular abundances blow up.