Before revision:  Here we  investigate whether, and to what extent, looping interactions between elements in the vicinity of an enhancer- promoter pair can influence the frequencyof enhancer-promoter contacts. Our polymer simulations show that a chromatin loop  formed by elements flanking either an enhancer or a promoter  suppresses enhancer-promoter interactions, working as a topological insulator.
After revision:  Here we investigate whether, and to what extent, looping interactions between elements in the vicinity of an enhancer- promoter pair can influence their contact frequency. Our equilibrium polymer simulations show that a chromatin loop formed by elements flanking either an enhancer or a promoter suppresses enhancer-promoter interactions, working as a topological insulator.