Before revision: In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth generalization , accumulation of liberalization-inhibiting proteins and peptides (such as interposition and ALARM peptides), and small inhibitory molecules (such as phosphate ), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix internationalization (osteopathic / orthodontia).
After revision: In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization , accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate ), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia /