Before revision: A sequence of pathological changes takes place in Alzheimer's disease , which can be assessed in vivo using various brain imaging methods . Currently, there is no appropriate statistical model available that can easily integrate multiple imaging modalities , being able to utilize the additional information provided from the combined data .
After revision: A sequence of pathological changes takes place in Alzheimer's disease , which can be assessed in vivo using various brain imaging methods . Currently, the most approaches to analyze statistical associations between brain regions rely on Pearson correlation. However, these are prone to spurious correlations arising from uninformative shared variance. Notably, there are no appropriate multivariate statistical models available that can easily integrate multiple imaging modalities , being able to utilize the additional information provided from the combined data .