Before revision:  Our results are in quantitative agreement with recent single-molecule FRET experiments and highlight the stark non-equilibrium nature of the process, showing that the Hsp70s are optimized to effectively convert chemical energy into mechanical work close to physiological conditions.
After revision:  Our results are in quantitative agreement with recent single-molecule FRET experiments and highlight the stark non-equilibrium nature of the process, showing that the Hsp70s are optimized to convert effectively chemical energy into mechanical work close to physiological conditions.