Before revision:  Through comparison with published experimental results we demonstrate the importance of appropriately representing IP3R gating, verify that our model is capable of reproducing known disease phenotypes in the calcium transientthrough alteration of channel properties , and examine how sensitive the cardiac cell is to IP3 . A key result of our study is that increasing IP3 concentration increases calcium transient duration but may not always lead to positive inotropy.
After revision:  Through comparison with published experimental results we demonstrate the importance of appropriately representing IP3R gating, verify that our model is capable of reproducing known disease phenotypes in the calcium transientthrough alteration of channel properties , and examine the sensitivity of the Ca2+ transient shape to properties of IP3R activation . A key result of our study is that increasing IP3 concentration increases calcium transient duration but may not always lead to positive inotropy.