Before revision: arRNAs are comprised of endogenous ADAR1 proteins with several RNA binding domains (RBDs) fused with a peptide, CRISPR-Cas13b protein, and a guide RNA (gRNA) between 100-150 nt in length for high editing efficiency designed to recruit the chimeric ADAR protein to a target site.
After revision: arRNAs consist of endogenous ADAR1 proteins with several RNA binding domains (RBDs) fused with a peptide, CRISPR-Cas13b protein, and a guide RNA (gRNA) between 100-150 nt in length for high editing efficiency designed to recruit the chimeric ADAR protein to a target site.