Before revision:  However, parameter uncertainty is a predominant issue in Systems Biology : the dynamical systems consist of a large number of states and parameters, while measurement data are often very noisy and data points and repetitions are usually few.
After revision:  In our point of view this approach is too restrictive, as, one the one hand, due to predominant parameter uncertainty numerical methods are generally difficult to apply to realistic models originating in Systems Biology : the dynamical systems consist of a large number of states and parameters, while measurement data are often very noisy and data points and repetitions are usually few.