Before revision: During asymmetric cell divisions, cortical dyneins generate forcesessential to position the spindle after polarity cues, prescribing daughter cells fate. In nematode zygote, cortical dynein pulls on microtubules transiently, raising the question of its targeting and dynamics.
After revision: During asymmetric cell divisions, cortical dyneins generate forcesessential to position the spindle to reflect polarity and ensure correct daughter cell fates. The transient cortical localization of dynein raises the question of its targeting and dynamics.