Before revision:  In a second step, we use these fields to perform  Langevin simulations which account for the desired molecular kinetics . By introducing the concept of 'temperature boosting' of the Langevin simulations, this combination of methods allows simulation of biomolecular processes occurring on multisecond timescales and beyond.
After revision:  In a second step, we use these fields to perform Langevin simulations which account for the desired molecular kinetics occurring on multisecond timescales and beyond.