Before revision:  The model faithfully reproduces both the binding free energy profiles and the probability densities of the perturbation energy as a function of the alchemical progress parameter \lambda. . The model offers a rationalization for the characteristic shape of the free energy profiles.
After revision:  The model faithfully reproduces both the binding free energy profiles and the probability densities of the perturbation energy as a function of the alchemical progress parameter \lambda. The model offers a rationalization for the characteristic shape of the free energy profiles.