Before revision:  Our results show that a rounding procedure is mandatory for such inference problems and suggest that a combination of LEM or LP with a subsequent PCA seems to perform the best  .
After revision:  Our results show that a rounding procedure is mandatory for such inference problems and suggest that a combination of LEM or LP with a subsequent PCA seems to perform the best . We finally compare the distributions of the HR with that of two heuristics based on the Artificially Centered hit-and-run (ACHR), gpSampler and optGpSampler. They show a good agreement with the results of the HR for the small network, while on genome scale models present inconsistencies .