Before revision: While cooperativity in ligand-induced receptor dimerization (e.g., EGF receptors) have been linked with receptor-receptor couplings via state-vector representations of physical observables, effects arising from higher-order oligomer  formations of unobserved receptors have received less attention.
After revision: While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via state-vector representations of physical observables, effects arising from higher-order oligomer formations of unobserved receptors have received less attention.