Before revision:  The metrics of root mean square error (RMSE or accuracy) , precision, recall, and Jaccard index (JAC) are currently used in the literature but in certain conditions fail in distinguishing qualities of different nanoscopy images .
After revision:  The metrics of root mean square minimum distance (RMSMD) as a quality metric for localization nanoscopy images. RMSMD measures an average, local, and mutual fitness between two sets of points. Its properties common to a distance metric as well as unique to itself are presented. The ambiguity, discontinuity, and inappropriateness of the metrics of accuracy, precision, recall, and Jaccard index (JAC) are currently used in the literature but in certain conditions fail in distinguishing qualities of different nanoscopy images .