Before revision: SMiLE-seq combines three critical functions that makes it unique from existing techniques: (1) the use of capillary pumps to optimize the loading of samples, (2) trapping molecular interactions on the surface of the microfluidic device through immunocapture of target transcription factors, (3) enabling the selection of DNA that is specifically bound to transcription factors from a pool of random DNA sequences.
After revision: SMiLE-seq combines three critical functions that makes it unique from existing techniques: (1) The use of capillary pumps to optimize the loading of samples, (2) Trapping molecular interactions on the surface of the microfluidic device through immunocapture of target transcription factors, (3) Enabling the selection of DNA that is specifically bound to transcription factors from a pool of random DNA sequences.