Before revision: The fundamental law for protein folding is the  Thermodynamic Principle : the amino acid sequence of a protein determines its native structure and the native structure has the minimum Gibbs free energy among all possible conformations of the protein.
After revision: The fundamental law for protein folding is the  Thermodynamic Principle : the amino acid sequence of a protein determines its native structure and the native structure has the minimum Gibbs free energy among all possible conformations of the protein.