Before revision:  and (iii) the replacement of the mechanosensing cells during bone remodelling, which resets the cell-specific reference state. The cell-specific reference state we propose is assumed to be encoded in the cells during their formation. It provides a long-lasting memory of the current mechanical stimulus gradually reset by bone remodelling.
After revision:  and (iii) the replacement of the mechanosensing cells during bone remodelling, which occurs over the long timescales of bone turnover. The other is cell desensitisation responses, which occur more rapidly and reversibly during an osteocyte's lifetime. The novelty of this theory is to propose that long-lasting memory of the current mechanical stimulus gradually reset by bone remodelling.