Before revision:  Worryingly, however, the use of realistic sample sizes to acquire empirical data systematically led to gross underestimates (often of one to two orders of magnitude) of c, calling for a reappraisal of many interpretations hitherto proposed in the literature and mostly based on genotypic richness.
After revision:  Worryingly, however, the use of realistic sample sizes to acquire empirical data systematically led to gross underestimates (often of one to two orders of magnitude) of c, calling for a reappraisal of many interpretations hitherto proposed in the literature , mostly based on genotypic richness.