Before revision:   In recent years, computational methods have made huge progress due to advance in computation speed and machine learning methods.
After revision:  Its importance comes from the relationship between the 3D structure and the function of a given protein or RNA. 3D structures also help to find the ligands of the protein, which are usually small molecules, a key step in drug design. Unfortunately, there is no shortcut to accurately obtain the 3D structure of a macromolecule. Many physical measurements of macromolecular 3D structures cannot scale up, due to their large labor costs and the requirements for lab conditions. In recent years, computational methods have made huge progress due to advance in computation speed and machine learning methods.