Before revision:  The two obstacles can be removed by knowledge-based methods, which combine knowledge learned from the known structures and biologists  knowledge of the folding process of protein or RNA. In the dissertation, I will present my results in building a knowledge-based method by using machine learning methods to tackle this problem.
After revision:  The two obstacles can be removed by knowledge-based methods, which combine knowledge learned from the known structures and biologists ' knowledge of the folding process of protein or RNA. In the dissertation, I will present my results in building a knowledge-based method by using machine learning methods to tackle this problem.