Before revision: Using a coarse-grained protein model, a molecular dynamics (MD) simulation of folding of one of the benchmark two-state folders, a beta-hairpin protein, has been performed. Each MD trajectory was divided into two parts - one to pass from an unfolded protein state to a native-like state by overcoming a free energy barrier that separates these states, and the other to explore the native-like states until the native state is attained .
After revision: Using a coarse-grained protein model, a molecular dynamics (MD) simulation of folding of one of the benchmark two-state folders, we studied how the exploration of native-like state by overcoming a free energy barrier that separates these states, and the other to explore the native-like states until the native state is attained .