Before revision:  We demonstrate the effectiveness of REAP by comparing the sampling to long continuous MD simulations and least-counts adaptive sampling on two model landscapes (L-shaped and circular) . We also demonstrate that the algorithm can be extended to more realistic systems such as alanine dipeptide and Src kinase.
After revision:  We demonstrate the effectiveness of REAP by comparing the sampling to long continuous MD simulations and least-counts adaptive sampling on two model landscapes (L-shaped and circular) , and realistic systems such as alanine dipeptide and Src kinase.