Before revision:  This instability manifests itself as ageing in the form of exponential distortions of gene expressions and metabolic profiles with age, and causes the characteristic increase in mortality rate with age as described by  the Gompertz law.
After revision:  This instability manifests itself as ageing in the form of distortion of gene expression and metabolic profiles with age, and causes the characteristic increase in mortality rate with age as described by the Gompertz law.