Before revision:  We present hierarchical pathway enrichment results stemming from aligned p-values, which are compared with results derived from enrichment analysis, as an external validation of our method.
After revision:  The applicability of this approach within life science is also demonstrated by applying it to three use cases of publically available datasets. Further we present hierarchical pathway enrichment results stemming from aligned p-values, which are compared with results derived from enrichment analysis, as an external validation of our method.