Before revision:  This algorithm, LinearDesign, can compute the approximate minimum free energy mRNA sequence for this spike protein in just 16 minutes using beam size b = 1, 000, with only 0.6\% loss in free energy change compared to exact search (i.e., b =  infinity, which costs 1.6 hours ).
After revision:  This algorithm, LinearDesign, can compute the approximate minimum free energy mRNA sequence for this spike protein in just 16 minutes using beam size b = 1, 000, with only 0.6\% loss in free energy change compared to exact search (i.e., b = + infinity, which costs 1.6 hours ).