Before revision:  In the context of peroxisomes, we use computational models to explore the hypothesis that physical clustering of autophagy receptor proteins on the surface of URLanelle provides an appropriate all-or-none signal for degradation. The pexophagy receptor proteins NBR1 and p62 are well characterized, though only NBR1 is essential for pexophagy (Deosaran et al. , 2013).
After revision:  In the context of peroxisomes, we use computational models to explore the hypothesis that physical clustering of autophagy receptor proteins on the surface of URLanelle provides an appropriate all-or-none signal URLanelle degradation. We explore this proposal using a computational model restricted to peroxisomes and the relatively well characterized pexophagy receptor proteins NBR1 and p62 are well characterized, though only NBR1 is essential for pexophagy (Deosaran et al. , 2013).