Before revision:  We find that these biases arise due to the difference in the bending energy barrier associated with DNA insertions. By coupling our model to a well-established framework for large-scale 3D URLanisation we discover that the non-random integration of HIV in human chromatin may be explained as due to large-scale accessibilityof interphase chromosomes.
After revision:  We find that these biases arise due to the difference in the bending energy barrier associated with DNA deformations. By considering a long chromosomal region in human T-cells during interphase, we discover that the non-random integration of HIV in human chromatin may be explained as due to large-scale accessibilityof interphase chromosomes.