Before revision: Two-dimensional partial covariance mass spectrometry ( 2D-pC-MS ) exploits the inherent fluctuations of fragment ion abundances across a series of tandem mass spectra, to identify correlated pairs of fragment ions produced along the same fragmentation pathway of the parent ion.The technique has been applied so far to peptides and oligonucleotides.
After revision: Two-dimensional partial covariance mass spectrometry ( 2D-pC-MS ) exploits the inherent fluctuations of fragment ion abundances across a series of tandem mass spectra, to identify correlated pairs of fragment ions produced along the same fragmentation pathway of the same parent (e.g. peptide) ion.