Before revision:  the signaling network that transmits the information from the receptors to the interior of the cell can never increase the precisionof sensing. We show that this limit arises from a fundamental trade-off between the removal of the extrinsic noise in the receptor state and the suppression of the intrinsic noise in the signaling network.
After revision:  the signaling network that transmits the information from the receptors to the interior of the cell can never increase precision. This limit arises from a fundamental trade-off between the removal of the extrinsic noise in the receptor state and the suppression of the intrinsic noise in the signaling network.