Before revision:  We consider some network descriptors based on these Mittaf-Leffler matrix functions which account for the "circulability" and "transmissibility" of the perturbations across the residues of a protein. We then apply this model and descriptors to the analysis of the communication effects produced by inhibitors of the main protease of COVID-19 . We find that the perturbation produced by strong inhibitors of the protease are propagated up to 60 \AA away from the binding site, confirming the long-range nature of intra-protein communication  .
After revision:  We then apply this model and descriptors to the analysis of the communication effects produced by inhibitors of the main protease of COVID-19 . We find that the perturbation produced by strong inhibitors of the protease are propagated up to 60 \AA away from the binding site, confirming the long-range nature of intra-protein communication .