Before revision:  On the interface level the entropy of the small interface assembly system is approximated by the sampling of the configurational space using the recently reported geometric method called  EASAL (efficient atlasing and sampling of assembly landscapes) . On the capsid level the method statistically learns how to combine the crucialness of interactions for assembly of each interface (obtained using EASAL) with crucialness of each interface for assembly of capsid (obtained from capsid structure and symmetry) to predict crucialness of interactions for capsid assembly .
After revision:  On the interface level the entropy of the small interface assembly system is approximated by the sampling of the configurational space using the recently reported geometric method called EASAL (efficient atlasing and sampling of assembly landscapes) , whose input consists of (a) the monomer geometry - atom coordinates; and for each interface type, (b) pair potentials for a candidate set of interactions along with Van der Waals sterics, and (c) structure of selected, small subassemblies. The method comes with rigorous accuracy-efficiency trade-off estimates. A second two-scale measure of cruciality of interactions and residues for capsid assembly .