Before revision:  Our alignments are large, dense, and contiguous, suggesting functional predictions of hundreds of currently unannotated proteins. Finally, our alignment of the protein-protein interaction network of two very different species--yeast and human--indicate that even distant species share a surprising amount of network topology with each other, suggesting that there may be broad similarities in internal cellular wiring across all life on Earth.
After revision:  Our alignment of the protein-protein interaction network of two very different species--yeast and human--indicate that even distant species share a surprising amount of network topology with each other, suggesting that there may be broad similarities in internal cellular wiring across all life on Earth.