Before revision:  We also demonstrate the use of "model reduction" in conjunction with leaping to circumvent this problem and expose a current need in this area: a model-reduction hierarchy analogous to that on which the leaping methods are based D. T. Gillespie, J. Chem. Phys. 113, 297 (2000); 115, 1716 (2001) . In situations where leaping is seen to perform well, we emphasize the significant advantages to using these methods over more traditional simulation approaches.
After revision:  We also demonstrate the use of "model reduction" in conjunction with leaping to circumvent this problem and expose a current need in this area: a model-reduction hierarchy analogous to that on which the leaping methods are based  . In situations where leaping is seen to perform well, we emphasize the significant advantages to using these methods over more traditional simulation approaches.