Before revision:  This study systematically reveals the global mechanism of miRNA functions in mouse stem cells by analyzing genome-wide physical interactions between miRNAs and their targets. Generally, miRNAs primarily repress developmental processes, but surprisingly the top up-regulated miRNAs do not directly target the pluripotent core factors as thought ;
After revision:  This study systematically reveals the global mechanism of miRNA functions in mouse pluripotent stem cells. Globally, miRNAs directly repress the pluripotent core factors during differentiation state. Surprisingly, during pluripotent state, the top important miRNAs do not directly target the pluripotent core factors as thought ;