Before revision:  Although significant progress has been made in developing computational algorithmsfor this purpose , current approaches are ineffective at designing sequences for complex targets, limiting their utility in real-world applications. However, an alternative that has shown significantly higher performance are human players of the online RNA design game EteRNA . Through many rounds of gameplay, these players have developed a collective library of "human" rules and strategies for RNA design that have proven to be more effective than current computational approaches, especially for complex targets .
After revision:  Although significant progress has been made in developing computational algorithmsfor this purpose , current approaches are ineffective at designing sequences for large or complex targets. On the other hand, human players of the online RNA design game EteRNA . Through many rounds of gameplay, these players have developed a collective library of "human" rules and strategies for RNA design that have proven to be more effective than current computational approaches, especially for complex targets .