Before revision:  However, we show that, without a detailed knowledge of the controlled systems, NECs cannot be prevented when IFCs are applied on bimolecular, and hence the vast majority of intracellular, networks .
After revision:  However, we show that, without a detailed knowledge of the controlled systems, NECs cannot be prevented when IFCs are applied on uncertain bimolecular (and hence most intracellular) networks, we show that preventing NECs generally becomes an intractable problem as the number of interacting molecular species increases .