Before revision:  The combination of these spatio-temporal aspects can be modulated to provide a switch-like response behavior without invoking sophisticated modeling of the signaling process as a sequence of cascade reactions and fine-tuned parameters.
After revision:  The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behavior without invoking sophisticated modeling of the signaling process as a sequence of cascade reactions and fine-tuned parameters.