Before revision:  Here we report computational evidence that Structural Maintenance of Chromosomes (SMC) proteins -- such as cohesins and condensins -- can cooperate with TopoII to establish a synergistic mechanism to resolve topological entanglements : SMC-driven loop extrusion (or diffusion) induces the spatial localisation of entanglements in turn increasing the topological pressure within knotted or linked regions.
After revision:  Here we report computational evidence that Structural Maintenance of Chromosomes (SMC) proteins -- such as cohesins and condensins -- can cooperate with TopoII to establish a synergistic mechanism to resolve topological entanglements . SMC-driven loop extrusion (or diffusion) induces the spatial localisation of entanglements in turn increasing the topological pressure within knotted or linked regions.