Before revision:  We  quantify the heterogeneity of breast cancer cell subtypes and systematically explore mechanistic models of MAP Kinase and PI3K (phosphoinositide 3-kinase)/AKT crosstalk based on the results of our method .
After revision:  We then perform a systematic, large-scale exploration of mechanistic models of MAPK-AKT crosstalk for each cluster. This analysis allows us to quantify the heterogeneity of breast cancer cell subtypes and systematically explore mechanistic models of MAP Kinase and PI3K (phosphoinositide 3-kinase)/AKT crosstalk based on the results of our method .