Before revision:  Our results indicate that ectoine and hydroxyectoine are able to bind more water molecules than urea on short scales. Furthermore we investigated the number and appearance of hydrogen bonds between the molecules and the solvent. The simulations show that some specific groups in the compatible solutes are able to form a pronounced ordering of the local water structure.
After revision:  Our results indicate that ectoine and hydroxyectoine are able to bind more water molecules than urea by a pronounced ordering of the local water structure.