Before revision:  Focusing on the peculiar case of antibody-antigen interaction, we designed a novel computational strategy based on the in-silico mutagenesis of residues of the antibody binding site  , where a Monte Carlo procedure aims at increasing the shape complementarity between the antibody paratope and its cognate antigen epitope .
After revision:  Focusing on the peculiar case of antibody-antigen interaction, we designed a novel computational strategy based on the in-silico mutagenesis of residues of the antibody binding site , where a Monte Carlo procedure aims at increasing the shape complementarity between the antibody paratope and a given epitope on a target protein surface .