Before revision:  Furthermore, we simulate the response of the cell when the external signal is changing directions, and we find that more symmetric cells can change their polarized state more effectively towards the new stimulus than cells which are elongated along the direction of the original stimulus  .
After revision:  Furthermore, we simulate the response of the cell when the external signal is changing directions, and we find that more symmetric cells can change their polarized state more effectively towards the new stimulus than cells which are elongated along the direction of the original stimulus , and thus enable roundish cells to turn faster, as has been observed in experiments. On the other hand, elongated cells preferentially polarize along their main axis even when a gradient stimulus appears from another direction. Furthermore, our 3D model can accurately capture the effect of binding and unbinding of important regulators of cell polarization to and from the cell membrane. This spatial separation of membrane and cytosol, not possible to capture in 1D or 2D models, leads to marked differences of our model from comparable lower-dimensional models .