Before revision:  Experiments show that joint multi-family EC analysis can reveal many more native contacts than single-family analysis even for a target family with 4000 sequence homologs, which makes many more protein families amenable to co-evolution-based structure and function prediction . We also find out that contact prediction may be worsened by merging multiple related families into a single one followed by single-family EC analysis, or by consensus of single-family EC analysis results .
After revision:  Experiments show that joint multi-family EC analysis can reveal many more native contacts than single-family analysis even for a target family with 4000 sequence homologs, which makes many more protein families amenable to co-evolution-based structure and function prediction .