Before revision:  Different from these single-family EC methods  , this paper presents a joint multi-family EC analysis method that predicts contacts of one target family by jointly modeling residue co-evolution in itself and also (distantly) related families with divergent sequences but similar folds, and enforcing their co-evolution pattern consistency based upon their evolutionary distance.
After revision:  Different from these single-family EC methods that focus on only a single protein family , this paper presents a joint multi-family EC analysis method that predicts contacts of one target family by jointly modeling residue co-evolution in itself and also (distantly) related families with divergent sequences but similar folds, and enforcing their co-evolution pattern consistency based upon their evolutionary distance.