Before revision:  The model has multiple predictions validated by existing experimental results , and particularly underscores cooperativity and synergy as a general design principle for multi-objective optimization in biology 
After revision:  The model has multiple predictions validated by existing experimental results . Through making analogy to a physical system with thermally activated barrier crossing and comparative reverse engineering analyses, the study reveals that the olfactory receptor selection system is optimally designed, and particularly underscores cooperativity and synergy as a general design principle for multi-objective optimization in biology