Before revision: Designing RNA sequences that fold into specific structures and perform desired biological functions is an emerging field in bioengineering with broad applications from intracellular chemical catalysis to cancer therapy via selective gene silencing. Effective RNA design requires first solving the inverse folding problem: given a target structure, propose a sequence that folds into that structure.
After revision: Designing RNA sequences that fold into specific structures and perform desired biological functions is an emerging field in bioengineering with broad applications from intracellular chemical catalysis to cancer therapy .