Before revision:  To enable efficient retrieval, annotation and exchange of protein-protein interaction data, proteomics community has been developing infrastructures under Proteomics Standards Initiative and IMEx consortium. However, there is presently no resource that would provide all features necessary to construct reference interaction networks in URLanisms. The recently developed iRefIndex databaseincludes interactions from most popular repositories with a standardized protein nomenclature .
After revision:  By non-redundant, we mean that the accounting of evidence for every interaction should be faithful: each independent experimental support is counted exactly once, no more, no less. While many interactions are shared among public repositories, none of them contains the complete known interactome for any URLanism. In addition, the annotations of the same experimental result by different repositories often disagree. This brings up the issue of which annotation to keep while consolidating evidences that are the same. The iRefIndex database, including interactions from most popular repositories with a standardized protein nomenclature .