Before revision:  Here by solving the analytical steady-state protein distribution in a general  model of stochastic gene expression with nonlinear feedback regulation, we reveal a quantitative relation between stochastic fluctuations and feedback topology , perfecting the results in Phys.
After revision:  Here by solving the analytical steady-state distribution of the protein copy number in a general model of stochastic gene expression with nonlinear feedback regulation, we reveal a quantitative relation between stochastic fluctuations and feedback topology , perfecting the results in Phys.