Before revision:  Within the model construct, the infectiousness of a viral carrier on a given day is identified with their symptom onset probability , which we characterise through extensive studies of the clinical literature. The well-known Lotka-Euler estimating equation can then be invoked to relate the daily growth rate \lambda of the epidemic with the basic reproduction number R_0 . We applied the disease spreading model to epidemic development in affected provinces across China following the Wuhan lockdown on January 23, 2020.
After revision:  Within the model construct, the infectiousness of a viral carrier on a given day is identified with their symptom onset probability , which we calibrated, into the percentage of the latent, pre-symptomatic and symptomatic groups through a novel mathematical procedure. We then estimate the reduction of the basic reproduction number R_0 . We applied the disease spreading model to epidemic development in affected provinces across China following the Wuhan lockdown on January 23, 2020.