Before revision:  We propose a novel framework to generate synthetic three-dimensional histological models based on a generator-discriminator pattern optimizing constrained features that construct a 3D model via a blender interface exploiting smooth shape continuity typical for biological specimens.
After revision:  We propose a novel framework to generate synthetic three-dimensional histological models based on a generator-discriminator pattern optimizing constrained features that construct a 3D model via a Blender interface exploiting smooth shape continuity typical for biological specimens.