Before revision:  We provide an atomistic, dynamic picture of the unbinding process, suggesting that the lock-and-key mechanism may need revision in terms of many routes to the lock that might be relevant for other receptor-ligand bonds.
After revision:  We provide an atomistic, dynamic picture of the unbinding process, suggesting that the lock-and-key mechanism may need revision in terms of many routes to the lock and rate-dependent induced-fit motions for intermediates, which might be relevant for other receptor-ligand bonds.