Before revision:  When trying to drive a system towards a target state, sometimes the most efficient control protocol is circuitous and will take the system through intermediate states . Clinically, the efficient control of the microbiome has pertinent applications for bacteriotherapies, which seek to remedy microbiome-affiliated diseases by directly altering the composition of the gut microbiome.
After revision:  When trying to drive a system towards a target state, sometimes the most efficient control protocol is circuitous and will take the system through intermediate steady states with sequential interventions . Clinically, the efficient control of the microbiome has pertinent applications for bacteriotherapies, which seek to remedy microbiome-affiliated diseases by directly altering the composition of the gut microbiome.