Before revision: We combine stochastic thermodynamics, large deviation theory, and information theory to derive fundamental limits on the accuracy with which single cells can detect external chemical concentrationsthrough arbitrarily complex, energy consuming nonequilibrium cell-surface receptors .
After revision: We combine stochastic thermodynamics, large deviation theory, and information theory to derive fundamental limits on the accuracy with which single cell receptors can detect external chemical concentrationsthrough arbitrarily complex, energy consuming nonequilibrium cell-surface receptors .