Before revision: With the enhancement of algorithms, cryo-EM  has become the most efficient technique to solve structures of molecules . Take a recent event for example, after the outbreak of COVID-19 in January, the first structure of 2019-nCoV Spike trimer was published in Marchusing cryo-EM, which has provided crucial medical insight for developing vaccines.
After revision: With the enhancement of algorithms, cryo-EM has become the most efficient technique to solve structures of molecules in solution, which has been recently demonstrated by the determination of COVID-19 in January, the first structure of 2019-nCoV Spike trimer was published in Marchusing cryo-EM, which has provided crucial medical insight for developing vaccines.