Before revision:  Interestingly,  DNA methylation in enhancer regions mediates these miRNA activations. Together, under mediation by DNA methylation, miRNAs directly repress development and mechanistically modulate the pluripotent signal pathways to help stem cells maintain pluripotency;
After revision:  Interestingly, DNA methylation, miRNAs directly repress development and mechanistically modulate the pluripotent signal pathways to help stem cells maintain pluripotency;