Before revision:  This is inspired by a similar scheme used for equilibrium simulations , and is based on the principle of maximum caliber that guarantees that as little subjective information as possible is added to a model, besides the available experimental data.
After revision:  This is inspired by a similar scheme used for equilibrium simulations . The maximum entropy principle provides a framework for using equilibrium experimental data and it has been shown that replica-averaged simulations, restrained using a static potential, are a practical and powerful implementation of such principle. Here we show that replica-averaged simulations restrained using a time-dependent potential are equivalent to the principle of maximum caliber that guarantees that as little subjective information as possible is added to a model, besides the available experimental data.