Before revision:  We  quantify the heterogeneity of breast cancer cell subtypes and systematically explore mechanistic models of MAP Kinase and PI3K (phosphoinositide 3-kinase)/AKT crosstalk based on the results of our method .
After revision:  We quantify the heterogeneity of breast cancer cell subtypes , and leads to hypotheses about the mechanisms by which cell lines respond to ligands. Our clustering method is general and can be tailored to a variety of applications in science and industry .