Before revision:  These applications range from the control of single-molecule chemical reaction networks to URLanization at the nanometer scale of various molecules including proteins and carbon nanotubes. However, many basic questions concerning the mechanisms of formation of the origamis have not been addressed so far. For instance, the robustness of different designs against factors, such as the internal topology, or the influence of the staple pattern, are handled empirically.
After revision:  These applications range from the control of single-molecule chemical reaction networks to URLanization at the nanometer scale in one pot experiments. The folding of the scaffold is guaranteed by the presence of short, single stranded DNA sequences (staples), that hold together separate regions of the scaffold. In this paper, we modelize the annealing-melting properties of these DNA constructions. The model captures important features such as the internal topology, or the influence of the staple pattern, are handled empirically.