Before revision:  An important question is how these proteins, with lifetimes measured in hours or days, can maintain memories for months or years. We present a computational model that shows how this problem can be solved by two interconnected feedback loops of molecular reactions, one involving the atypical protein kinase PKM{\zeta} and its messenger RNA, the other involving PKM{\zeta} and GluR2-containing AMPA receptors.
After revision:  An important question is how these proteins, with lifetimes measured in hours or days, can maintain memories for months or longer, in spite of the fact that many of the participating molecules have much shorter life spans. Here we present a computational model that shows how this problem can be solved by two interconnected feedback loops of molecular reactions, one involving the atypical protein kinase PKM{\zeta} and its messenger RNA, the other involving PKM{\zeta} and GluR2-containing AMPA receptors.