Before revision:  The model demonstrates that tranilast delays the formation of the NLRP3 inflammasome, and thus may alter the mode of cell death from inflammatory (pyroptosis) to non-inflammatory ( e.g., apoptosis)  .
After revision:  The model demonstrates that tranilast delays the formation of the NLRP3 inflammasome, and thus may alter the mode of cell death from inflammatory (pyroptosis) to non-inflammatory ( e.g., apoptosis) . The single-cell model is being implemented in a SARS-CoV-2 Tissue Simulator, in collaboration with a multidisciplinary coalition investigating within host-dynamics of COVID-19. In this paper, we provide an overview of the SARS-CoV-2 Tissue Simulator and highlight the effects of pyroptosis on a cellular level .