Before revision:  Furthermore, unfolding and refolding of the domain significantly slows the domain opening and closing rates of cCaM , a distinct scenario which can potentially influence the mechanism of calcium binding to each domain.
After revision:  Furthermore, unfolding and refolding during the conformational change. Transient unfolding significantly slows the domain opening and closing rates of cCaM , a distinct scenario which can potentially influence the mechanism of calcium binding to each domain.