Before revision:  This is inspired by a similar scheme used for equilibrium simulations , and is based on the principle of maximum caliber that guarantees that as little subjective information as possible is added to a model, besides the available experimental data. We also show that the same algorithm, in the case of simplified models, can be used to speed up the computational time needed by a simulation by one to two orders of magnitude .
After revision:  This is inspired by a similar scheme used for equilibrium simulations , and is based on the principle of maximum caliber , the dynamic version of the principle of maximum entropy, and thus may allow to integrate time-resolved data in molecular dynamics simulations. We provide an analytical proof of the equivalence as well as a computational validation making use of simple models and synthetic data. Some limitations and possible solutions are also discussed .