Before revision:  We apply it to all Pfam domains without a known structure and provide high confidence models for 25\% of these so-called "dark " families , a calculation that took less than a week on a small cluster with 200 available cores . DMPfold provides models for 16\% of human proteome UniProt entries without structures, can generate accurate models with alignments of fewer than 100 sequences in some cases, and is freely available.
After revision:  We apply it to all Pfam domains without known structures, confident models for 25\% of these so-called "dark " families , a calculation that took less than a week on a small cluster with 200 available cores . DMPfold provides models for 16\% of human proteome UniProt entries without structures, can generate accurate models with alignments of fewer than 100 sequences in some cases, and is freely available.