Before revision: TMB has been validated as a predictive biomarker with several applications, including associations reported between different TMB levels and patient response to immune checkpoint inhibitor (ICI) therapy in a variety of cancers.<ref name="ref2"> While both TMB and mutational signatures give us critical information about cancer behaviour, they have different definitions.
After revision: <ref name="TMB Science">TMB has been validated as a predictive biomarker with several applications, including associations reported between different TMB levels and patient response to immune checkpoint inhibitor (ICI) therapy in a variety of cancers.<ref name="ref2"> While both TMB and mutational signatures give us critical information about cancer behaviour, they have different definitions.