Before revision:  Users can control the composition and appearance of the subnetwork . Saving results as node and network attributes, CytoITMprobe allows Cytoscape users to manipulate and visualize context-specific information in a manner more flexible than its web predecessor .
After revision:  Users can control the composition and appearance of the subnetwork and interchange their ITM Probe results with other software tools through tab-delimited files. The main strength of CytoITMprobe is its flexibility. It allows the user to specify as input any Cytoscape network, rather than being restricted to the pre-compiled protein-protein interaction networks available through the ITM Probe web service. Users may supply their own edge weights and directionalities. Consequently, as opposed to ITM Probe web service, CytoITMprobe can be applied to many other domains of network-based research beyond protein-networks .