Before revision: Experimental evidence indicates that proteins are marginally stable. Unlike all previous proposals here we suggest, on a statistical thermodynamics basis, that the upper bound of the marginal stability of proteins also belongs to biomacromolecular complexes and its origin should be sought on fluctuations of the pairwise and many-body interactions on both the macro-molecules and the solvent.
After revision: Here we propose that the upper bound of the marginal stability of proteins also belongs to biomacromolecular complexes and its origin should be sought on fluctuations of the pairwise and many-body interactions on both the macro-molecules and the solvent.