Before revision:  First, KiNetX  identifies and eliminates all kinetically irrelevant species and elementary reactions to guide and, thereby, accelerate the exploration of chemical reaction space.
After revision:  First, KiNetX evaluates the kinetic relevance of every species in a (yet incomplete) reaction network to confine the search for new elementary reaction steps only to those species that are considered possibly relevant. Second, KiNetX identifies and eliminates all kinetically irrelevant species and elementary reactions to guide and, thereby, accelerate the exploration of chemical reaction space.