Before revision:  On the capsid level the method statistically learns how to combine the crucialness of interactions for assembly of each interface (obtained using EASAL) with crucialness of each interface for assembly of capsid (obtained from capsid structure and symmetry) to predict crucialness of interactions for capsid assembly .
After revision:  On the capsid level the method statistically learns how to combine the crucialness of interactions for assembly of each interface (obtained using EASAL) with crucialness of each interface for assembly of capsid (obtained from capsid structure and symmetry) to predict crucialness of interactions for capsid assembly is obtained as follows. Combinatorial entropy is used to define the cruciality of an interface for successful assembly of the capsid. This is combined with the interface-scale prediction using statistical learning.