Before revision: Solvation shell dynamics is a critical determinant of protein and enzyme functions. Here we investigate how the dynamics of the solvation shell changes for molecules embedded in lipid membranes during an acoustic impulse . Solvation sensitive fluorescence probes, Laurdan, embedded in multi-lamellar lipid vesicles in water,  were exposed to broadband pressure impulses of the order of 1MPa peak amplitude and 10{\mu}s pulse duration.
After revision: Ultrasound is increasingly being used to modulate the properties of biological membranes for applications in drug delivery and neuromodulation. While various studies have investigated the mechanical aspect of the interaction such as acoustic absorption and membrane deformation, it is not clear how these effects transduce into biological functions, for example, changes in the permeability or the enzymatic activity of the membrane. A critical aspect of the activity of an enzyme is the thermal fluctuations of its solvation or hydration shell. Thermal fluctuations are also known to be directly related to membrane permeability. Here solvation shell changes of lipid membranes subject to an acoustic impulse . Solvation sensitive fluorescence probes, Laurdan, embedded in multi-lamellar lipid vesicles in water, were exposed to broadband pressure impulses of the order of 1MPa peak amplitude and 10{\mu}s pulse duration.