Before revision: The major objective of this paper is to introduce a novel method for the functional annotation of genes. Our method is based on a graph theoretical measure we call joint betweenness, which is an extension of the well known betweenness centrality measure, involving pairs of genes. We apply our method to the transcriptional regulatory network of yeast to, first, provide a large scale proof of concept of our method and, second, make predictions about the biological function of previously unknown genes .
After revision: This paper has been withdrawn .