Before revision:  For the canonical inhibitory serpin alpha1-antitrypsin  (A1AT), mutations can result in protein deficiencies leading to lung disease and polymerization prone mutants can accumulate in hepatocytes leading to liver disease.
After revision:  For the canonical inhibitory serpin alpha1-antitrypsin (A1AT), mutations can result in protein deficiencies leading to lung disease , and misfolded mutants can accumulate in hepatocytes leading to liver disease.