Before revision:  Significant effort has been committed to harness gene expression data as real-valued matrices for multiple analyses while accounting for time-to-event modeling by including survival times . Traditional biological analysis has focused separately on non-negative matrix factorization (NMF) of the gene expression data matrix and survival regression with Cox proportional hazards model.
After revision:  Significant effort has been committed to harness gene expression data as real-valued matrices for multiple analyses while accounting for time-to-event modeling by including survival times , many traditional analyses have focused separately on non-negative matrix factorization (NMF) of the gene expression data matrix and survival regression with Cox proportional hazards model.