Before revision:  In this work we predict how model quality degrades as a function of the number of sequences N, sequence length L, amino-acid alphabet size q, and the degree of conservation of the MSA  in different applications of the Potts models: In "fitness" predictions of individual protein sequences,  predictions of the effects of single-point and multiple mutations, and 3-d contact prediction in protein structure.
After revision:  In this work we predict how model quality degrades as a function of the number of sequences N, sequence length L, amino-acid alphabet size q, and the degree of conservation of the MSA in different applications of the Potts models: In "fitness" predictions of individual protein sequences, predictions of the effects of single-point mutations, in "double mutant cycle" predictions of epistasis, and in 3-d contact prediction in protein structure.