Before revision:  The results generated by XOmiVAE were validated by both the biomedical knowledge and the performance of downstream tasks . XOmiVAE explanations of deep learning based cancer classification and clustering aligned with current domain knowledge including biological annotation and  literature, which shows great potential for novel biomedical knowledge discovery from deep learning models .
After revision:  The results generated by XOmiVAE were validated by both the biomedical knowledge and the performance of downstream tasks and the biomedical knowledge. In our experiments, XOmiVAE explanations of deep learning based cancer classification and clustering aligned with current domain knowledge including biological annotation and literature, which shows great potential for novel biomedical knowledge discovery from deep learning models .