Before revision: Markov state models (MSMs) are a powerful means of understanding the structure and function of biomolecules by describing their free energy landscapes as a set of local minima (a.k.a. states) and the probabilities of transitioning between them. Unfortunately, it can be difficult to gain an intuition for an MSM because they typically must have tens of thousands of sates to quantitatively describe the rugged landscapes of most biomolecules .
After revision: Markov state models (MSMs) are a powerful means of understanding the structure and function of proteins and other molecular systems. However, they are typically too complicated to understand .