Before revision:  We compare the proposed method to an EnKF-based parameter drift algorithm, where periodicity is not guaranteed , using synthetic data generated from the  FitzHugh-Nagumo system which models the spiking dynamics of a neuron.
After revision:  We compare the proposed method to an EnKF-based parameter drift algorithm, where periodicity is not guaranteed . We demonstrate the effectiveness of the proposed approach on two biological examples: a synthetic example with data generated from the FitzHugh-Nagumo system which models the spiking dynamics of a neuron.