Before revision:  Regarding the genome as a string of 1s and 0s based on a systematically optimized set of peaks and calculating the Hamming distance enables us to quantitatively evaluate differences between samples of hematopoietic cells , classify cell types , and infer the origin of leukemic cells , potentially leading to a better understanding of leukemia pathogenesis.
After revision:  Regarding the genome as a string of 1s and 0s based on a systematically optimized set of peaks and calculates the Hamming distances between the strings. This algorithm with the systematically optimized set of peaks enables us to quantitatively evaluate differences between samples of hematopoietic cells , classify cell types , and infer the origin of leukemic cells , potentially leading to a better understanding of leukemia pathogenesis.