Before revision:  To alleviate this problem, we introduce here partial applications of rules as a basis for the efficient implementation of strategies that are not only well suited for exploration of chemistries defined by graph grammars, but that are also applicable in a generalgraph rewriting context as well. As showcases, we explore a complex chemistry based on the Diels-Alder reaction to explore specific subspaces of the molecular space. As a non-chemical application we use the framework of exploration strategies to model an abstract graph rewriting problem to construct high-level transformations that cannot be directly represented by the Double-Pushout formalism starting from simple DPO transformation rules .
After revision:  To alleviate this problem, we introduce here a generic framework for the specification of exploration strategies in graph-rewriting systems. Using key examples of complex chemical networks from sugar chemistry and the realm of metabolic networks we demonstrate the feasibility of a high-level transformations that cannot be directly represented by the Double-Pushout formalism starting from simple DPO transformation rules .