Before revision:  The results show that when only the reaction kinetics is considered, just one of the pathways may be responsible for apoptosis induction. This pathway requires a high catalase concentration (in the order of mM) to be inhibited, which thus can be assumed to be the condition of cancer cells before CAPtreatment, and it can only be reactivated by inactivation of about 99\% of the catalase. This model is a first step into the efforts that should be taken to quantitatively understand the complex mechanisms of the role of CAP and catalase in the apoptosis-inducing signaling pathways, but will need to be further extended before it can capture the entire mechanism. Still, it gives some important insights regarding necessary conditions in order for the proposed mechanism to represent a feasible explanation of selective CAP treatment of cancer cells .
After revision:  The results show that a catalase-dependent reactivation of the two apoptotic pathways of interest is unlikely to contribute to the observed anti-cancer effect of CAP. Thus, we believe that other theories of the underlying cause should be considered and evaluated to gain knowledge about the principles of CAP-induced cancer cell death .