Before revision:  Together, under mediation by DNA methylation, miRNAs directly repress development and mechanistically modulate the pluripotent signal pathways to help stem cells maintain pluripotency; yet miRNAs directly repress both pluripotency and metabolism to facilitate cell differentiation .
After revision:  Together, under mediation by DNA methylation, and decreasing methylation in turn activates the top miRNAs. This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system would eventually activate pluripotent core factors for pluripotency. Therefore, miRNAs systematically repress development and inhibit the epigenetic system to modulate stem cell pluripotency .