Before revision: Knowing the assembly-crucial interaction of virus capsid help us understand its assembly process. Validating assembly-crucial interaction via mutagenesis experiments in wet lab is usually very slow. We predict the assembly crucial interactions by measuring the entropy change of the capsid assembly system before and after the removal of each interaction.
After revision: We predict crucial inter-atomic interactions between monomers for the autonomous assembly of three icosahedral viral capsids, Adeno Associated Virus type 2 (AAV2), Murine Parvo Virus (MVM), and Bromo Mosaic Virus (BMV), by approximating changes in the partition function of the capsid assembly system before and after the removal of each interaction.