Before revision:  Moreover , our approach has the minimal elements necessary to reproduce mechanical crosstalk between both cell-cell and cell substrate adhesion systems. We found that an increase in cell motility increased junctional tension and monolayer stress on cells several cell diameters behind the island edge. Conversely, an increase in junctional contractility increased the length scale within the island where traction forces were generated. We conclude that the computational method presented here has the capacity to reproduce emergent properties ( distribution of cellular forces and mechanical crosstalk ) of epithelial cell aggregates and make predictions for experimental validation.
After revision:  Moreover , our approach has the minimal elements necessary to reproduce the distribution of cellular forces and mechanical crosstalk ) of epithelial cell aggregates and make predictions for experimental validation.