Before revision: A sequence of pathological changes takes place in Alzheimer's disease , which can be assessed in vivo using various brain imaging methods . Currently, there is no appropriate statistical model available that can easily integrate multiple imaging modalities , being able to utilize the additional information provided from the combined data .
After revision:  Alzheimer's disease , which can be assessed in vivo using various brain imaging methods . Currently, there is no appropriate statistical model available that can easily integrate multiple imaging modalities , being able to utilize the additional information provided from the combined data .