Before revision:  Together, under mediation by DNA methylation, miRNAs directly repress development but only modulate the pluripotent signal pathways in the pluripotent state; while in the developmental state miRNAs directly suppress both metabolism and pluripotency .
After revision:  Together, under mediation by DNA methylation, miRNAs directly repress development but only modulate the pluripotent signal pathways to help stem cells maintain pluripotency; yet miRNAs directly repress both pluripotency and metabolism to facilitate cell differentiation .