Before revision: Clinical significance Addiction Due to the effect of reward cues and Pavlovian-instrumental transfer on amplifying incentive salience for rewarding stimuli, PIT is believed to be one of the mechanisms responsible for producing "cue-triggered wanting", or craving, for a drug that occurs when an individual with a drug addiction is exposed to drug cues even after long periods of abstinence.
After revision: Clinical significance Addiction Due to the effect of reward cues and Pavlovian-instrumental transfer on the amplification of incentive salience for rewarding stimuli, PIT is believed to be one of the mechanisms responsible for producing "cue-triggered wanting", or craving, for a drug that occurs when an individual with a drug addiction is exposed to drug cues even after long periods of abstinence.