Before revision:  Here, we develop a new algorithm that extends existing approaches for de novo objective generation and solve it using the alternating direction method of multipliers (ADMM) . We demonstrate our approach on a genome-scale model and show that it identifies de novo objectives from measured fluxes with tunable sparsity .
After revision:  Here, we develop a new algorithm that extends existing approaches for de novo objective generation and solve it using the alternating direction method of multipliers (ADMM) . We demonstrate our approach on a genome-scale model and show that our algorithm can recover cellular constraint reactions .