Before revision:  The MiStImm simulation software package and the simulation results are available at the address URL
After revision:  The simulations show that our self-centered model is realistic. Moreover, in case of a primary adaptive immune reaction, it can destroy infections more efficiently than a classical nonself-centered model. Predictions of our theoretical model were clinically supported by autoimmune-related adverse events in high-dose immune checkpoint inhibitor immunotherapy trials and also by safe and successful low-dose immune checkpoint inhibitor combination treatment of heavily pretreated stage IV cancer patients who had exhausted all conventional treatments. The MiStImm simulation tool and source codes are available at the address URL