Before revision:  We thus point to the need for more data for the cases in which several sectors are predicted by SCA .
After revision:  We thus point to the dominating factor in SCA, and can alone be used to make statistically equivalent functional predictions. Therefore, we suggest shifting the experimental focus to proteins for which SCA identifies several sectors. Correlations in protein alignments, which have been shown to be informative in a number of independent studies, would then be less dominated by sequence conservation .