Before revision: The macromolecules that encode and translate information in living systems  exhibit distinctive structural asymmetries, including homochirality or mirror image asymmetry and 3'-5' directionality, that are invariant across all life forms.
After revision: The macromolecules that encode and translate information in living systems , DNA and RNA, exhibit distinctive structural asymmetries, including homochirality or mirror image asymmetry and 3'-5' directionality, that are invariant across all life forms.