Before revision:  By reliably and rapidly narrowing down target interactions, these in-silico predictions can inform and reduce the time spent on  time-consuming in-vitro and in-vivo experimentation .
After revision:  By reliably and rapidly narrowing down target interactions, these in-silico predictions can inform and reduce the time spent on more computationally intensive in-silico analyses, and time-consuming in-vitro and in-vivo experimentation .