Before revision:  Our analyses indicate that the rhythm of SMC cluster could (1) correspond to significant enhancements of signal communications among remote cells, (2) respond to calcium sparks against transient stimulations for driving follow-up globally-oscillating modes, and (3) characterize the globally-oscillating modes via frog-leap (non-molecular-diffusion) calcium waves across inhomogeneous SMCs.
After revision:  Our analyses indicate that the rhythm of SMCs could (1) correspond to significant enhancements of signal communications among remote cells, (2) respond to calcium sparks against transient stimulations for driving follow-up globally-oscillating modes, and (3) characterize the globally-oscillating modes via frog-leap (non-molecular-diffusion) calcium waves across inhomogeneous SMCs.