Before revision: To induce Long-Term Potentiation (LTP), Ca2+ activates CAMKII and PKC, causing phosphorylation and insertion of AMPARs, while Long-Term Depression (LTD) occurs by Ca2+ activating protein phosphatases, which dephosphorylate and cause internalization of AMPARs.
After revision: To induce long-term potentiation (LTP), Ca2+ activates CAMKII and PKC, causing phosphorylation and insertion of AMPARs, while long-term depression (LTD) occurs by Ca2+ activating protein phosphatases, which dephosphorylate and cause internalization of AMPARs.