Before revision: Nematode species are well-known for their invariant cell lineage pattern , including reproducible division timing, volume segregation, fate specification and migration trajectory for each and every cell during embryonic development. Here, we study the fundamental principle optimizing cell lineage pattern with Caenorhabditis elegans. Combining previous knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume  , we propose a model to simulate lineage  by altering cell volume segregation ratio in each division, and quantify the derived lineage 's performance in proliferation rapidity , fate diversity and space robustness (PFS Model) .
After revision: Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume , we propose a model to simulate lineage by altering cell volume segregation ratio in each division, and quantify the derived lineage 's performance in proliferation rapidity , fate diversity and space robustness (PFS Model) .