Before revision:  cadherins and nectins in adherens junctions , to comprehend the current state of the art, to highlight differences and similarities among the trafficking pathways, and to identify topics that are not fully understood . Clathrin-mediated endocytosis appears to be the main, but not exclusive, mode of internalization.
After revision:  cadherins and nectins in adherens junctions ; to identify underlying common mechanisms; to highlight their functional consequences on barrier function; and to identify knowledge gaps . Clathrin-mediated endocytosis appears to be the main, but not exclusive, mode of internalization.