Before revision:  Recently, a powerful generalization of MSMs has been introduced, the variational approach of conformation dynamics (VAC) and its special case the time-lagged independent component analysis (TICA), which allow us to approximate molecular kinetics and reaction coordinates by linear combinations of smooth basis functions or order parameters.
After revision:  Recently, a powerful generalization of MSMs has been introduced, the variational approach of conformation dynamics (VAC) and its special case the time-lagged independent component analysis (TICA), which allow us to approximate slow collective variables and molecular kinetics by linear combinations of smooth basis functions or order parameters.