Before revision:  We use k-nearest neighbors of cities to mimic regions and allow analysis of COVID-19 dissemination based on the comparison of a city under consideration and its neighborhood , moreover, such analysis is performed based on periods of time , which facilitates  assessment of isolation policies.
After revision:  We use k-nearest neighbors of cities to mimic regions and allow analysis of COVID-19 dissemination based on the comparison of a city under consideration and its neighborhood , moreover, such analysis is performed based on periods , which facilitates assessment of isolation policies.