Before revision:  The insufficient levelof ACE2 exacerbates the inflammatory response eventually leading to death, but if the initial levels of ACE2 are high the immune system has enough time to resolve the infection before it gets to extreme consequences. These results are consistent with previous hypothesis on the protective role of ACE2, and suggest that , counterintuitively, drugs that act synergistically with ACE2 and enhance its expression, such as ACE inhibitors and angiotensin receptor blockers used to treat high blood pressure, may offer a promising therapy against the most adverse effects of the Covid-19 disease.
After revision:  The insufficient levelof ACE2 exacerbates the inflammatory response eventually leading to death, but if the initial levels of ACE2 are high the cross-talk between ACE2, and suggest that , counterintuitively, drugs that act synergistically with ACE2 and enhance its expression, such as ACE inhibitors and angiotensin receptor blockers used to treat high blood pressure, may offer a promising therapy against the most adverse effects of the Covid-19 disease.