Before revision:  Results of the minimalistic in silico modeling indicate that the resistant cells could bias the evolution of the therapies towards more toxic ones by inhibiting non-efficient therapies. In this way , not only  therapies govern the evolution of different  phenotypes, but variable resistances of cells govern the evolution of  therapies as well  .
After revision:  As a result , not only therapies govern the evolution of different phenotypes, but variable resistances of cells govern the evolution of therapies as well .