Before revision:  We investigated whether the protein Tau changes the response of cells exposed to acute DNA damage . We report that Tau depletion in neuroblastoma cells severely dysregulate P53 activity and leads to reduced cell death counterbalanced by increased cell senescence.
After revision:  We investigated whether the protein Tau changes the response of cells exposed to acute DNA damage was studied in neuroblastoma cells severely dysregulate P53 activity and leads to reduced cell death counterbalanced by increased cell senescence.