Before revision:   . Perturbations are trained on a suitable set of systems for which the native structure is known . A convolutional window is used to include neighboring reactivities in the SHAPE nodes of the network, and regularization terms limit overfitting improving transferability.
After revision:  . Perturbations are trained to increase the ensemble populations of a representative set of known native RNA structures. In the chemical probing nodes of the network, and regularization terms limit overfitting improving transferability.