Before revision:  However, a detailed understanding of such response is still lacking, as it involves processes occurring over a wide range of length- and time-scales. Experimentally, one of the preferred methods to investigate how crawling cells react to such stimulation is to apply cyclic stretching to the substrate to which they are attached. Studying the shape deformations and changes in motility, as well as the localization of characteristic proteins (e.g., actin or myosin) or the orientation of the actin filament network inside of the cell under stretching, has provided crucial information on their mechano-sensing abilities. In particular, cells have been shown to reorient under such perturbations, aligning at specific angles with respect to the stretching direction that depends strongly on the type of cell .
After revision:  In experiments, cells placed on cyclically stretched substrates have been shown to reorient under such perturbations, aligning at specific angles with respect to the stretching direction that depends strongly on the type of cell .