Before revision:  In this study, we adopt a different approach whereby macroscopic flows are redirected throughout the bioreactor along patterned channels in the scaffold that result in optimized shear stress distributions  .
After revision:  In this study, we adopt a different approach whereby macroscopic flows are redirected throughout the bioreactor along patterned channels in the scaffold that result in optimized shear stress distributions that are optimized for uniformity centered on a target value .