Before revision:  A systematic evaluation using simulated data from the DREAM5 Systems Genetics challenge demonstrated that the novel tests outperformed existing causal inference methods as well as all challenge submissions. We confirmed these results using siRNA silencing, ChIP-sequencing and microRNA target data to validate causal gene-gene and microRNA-gene interactions inferred from genotype, microRNA and mRNA sequencing data of nearly 400 human individuals from the Geuvadis study.
After revision:  A systematic evaluation using simulated data from the DREAM5 Systems Genetics challenge and microRNA-gene interactions inferred from genotype, microRNA and mRNA sequencing data of nearly 400 human individuals from the Geuvadis study.