Before revision:  This is clearly a tremendous improvementfor the description of gene expression, but it is also a new challenge because a stochasticity dimension has now to be integrated to properly infer gene regulatory networks - mRNA synthesis is now acknowledged to occur in a highly bursty manner.
After revision:  Despite this considerable precision improvement, inferring regulatory networks remains challenging because stochasticity now proves to play a fundamental role in gene expression. In particular, mRNA synthesis is now acknowledged to occur in a highly bursty manner.