Before revision:  We introduce a computation model for crawling cells on such periodically stretching substrates that is able to account for the complex shape deformations, the URLanization of the actin-network, and the coupling to the substrate . As in experiments, we are able to observe preferential alignment along perpendicular, parallel, or oblique angles to the stretching, depending on the frequency of stretching, as well as on the type of response exhibited by our model cells .
After revision:  We introduce a computation model for crawling cells on such periodically stretching substrates that is able to account for the complex shape deformations, the URLanization of the actin-network, and the coupling to the substrate through the focal adhesion sites. In particular, we focus on the role of the focal adhesion dynamics, and show that the reorientation under cyclic stretching is strongly dependent on the frequency of stretching, as well as on the type of response exhibited by our model cells .