Before revision: Summary: Non-canonical nucleic and amino acid monomers are essential to enhance the information capacity, functional capabilities, and stability of DNA, RNA, and protein biopolymers. However, there are few tools for describing the primary structure of biopolymers that include non-canonical monomers.
After revision: Summary: Non-canonical nucleic and amino acid monomers are essential to enhance the information capacity, functional capabilities, and stability of DNA, RNA, proteins, and complexes, we do not fully understand how networks of non-canonical monomers.