Before revision:  We consider a canonical biochemical network that reads out the state of a receptor and show rigorously how it relates to a measurement protocol of the type studied in the computational literature. We find that regardless of the network parameters , the biochemical network can never reach the thermodynamic limit of efficiency, and faces a tradeoff between accuracy and dissipation that is more severe than and qualitatively distinct from the tradeoff required thermodynamically .
After revision:  We consider a canonical biochemical readout network generates correlations; extracting no work from these correlations sets a lower bound on dissipation. For general input , the biochemical network can never reach the thermodynamic limit of efficiency, and faces a tradeoff between accuracy and dissipation that is more severe than and qualitatively distinct from the tradeoff required thermodynamically .