Before revision:  In contrast to the general belief that the change in the amount of transcription factor (TF ) precedes the histone state change, the flux drives histones to be modified prior to the change in the amount of TF in the self-regulating circuits.
After revision:  In contrast to the general belief that the change in the amount of TF precedes the histone state change, the flux drives histones to be modified prior to the change in the amount of TF in the self-regulating circuits.