Before revision:  An experiment that an unbiased estimator achieving the Fisher information and Cramer-Rao lower bound (CRLB) localizes emitters frame by frame independently is simulated and the result demonstrates the superior sensitivity of RMSMD over the other four metrics .
After revision:  The unbiased Gaussian estimator that achieves the Fisher information and Cramer-Rao lower bound (CRLB) localizes emitters frame by frame independently is simulated and the result demonstrates the superior sensitivity of RMSMD over the other four metrics .