Before revision:  In all four systems, the REAP algorithm outperforms the conventional single long trajectory simulation approach as it is able to consistently discover more states as a function of simulation time .
After revision:  In all four systems, the REAP algorithm consistently demonstrates its ability to explore conformational space faster than the other two methods when comparing the expected values of the landscape discovered for a given amount of time. The key advantage of REAP is on-the-fly estimation of the importance of collective variables, which makes it particularly useful for systems with limited structural information .