Before revision:  During pluripotency miRNAs primarily and mechanistically target and repress developmental processes, but surprisingly  miRNAs do not directly target the pluripotent core factors but only mediate extrinsic signal pathways associated with pluripotency.
After revision:  During pluripotency miRNAs primarily and mechanistically target and repress developmental processes, but surprisingly the top up-regulated miRNAs do not directly target the pluripotent core factors but only mediate extrinsic signal pathways associated with pluripotency.