Before revision:  Flimma URL addresses this issue by implementing the state-of-the-art gene expression workflow limma voom in a federated, privacy-preserving manner  . Flimma results are identical to those generated by limma voom on combined datasets even in imbalanced scenarios where meta-analysis approaches fail.
After revision:  Flimma URL addresses this issue by implementing the state-of-the-art gene expression workflow limma voom in a federated, privacy-preserving manner , i.e. patient data never leaves its source site . Flimma results are identical to those generated by limma voom on combined datasets even in imbalanced scenarios where meta-analysis approaches fail.