Before revision:  The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes , however. Most recently , deep learning techniques have shown promise in allowing  residue-residue contacts to be predicted accurately even for shallow sequence alignments.
After revision:  The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes . Recently , deep learning techniques have shown promise in allowing residue-residue contacts to be predicted accurately even for shallow sequence alignments.