Before revision:  This theory includes (i) a cell-specific reference state that enables mechanosensing cells to gauge a mechanical stimulus and to respond to it; (ii) a rapid, but partial desensitisation of the mechanosensing cells to the mechanical stimulus;
After revision:  This theory assumes that osteocytes are formed adapted to their current local mechanical environment through modulation of morphological and genotypic osteocyte properties involved in mechanical sensitivity. We distinguish two main types of physiological responses by which osteocytes subsequently modify the reference mechanical state. One is the mechanosensing cells to the mechanical stimulus;