Before revision: Since the estimate provides little support for its causal role mutation accumulation in human aging, damaging mutations, germline and somatic, can only contribute to aging as a result of higher-order effects including interactions of multiple forms of damage.
After revision: Since the estimate provides little support for causal role mutation accumulation in human aging, damaging mutations, germline and somatic, can only contribute to aging as a result of higher-order effects including interactions of multiple forms of damage.