Before revision:  While the recent past has seen rapid growth in scientific and technological knowledge, relatively little is known about the manner in which science and technology develop and coalesce knowledge into larger structures that enable or constrain future breakthroughs.
After revision:  While the recent past has seen rapid growth in scientific and technological knowledge, relatively little is known about the manner in which scientific and technological knowledge develop and coalesce knowledge into larger structures that enable or constrain future breakthroughs.