Before revision:  Here, a novel approach, termed the Chronological Hurst Exponent (CHE), is proposed, which hypothesizes that changes in intrinsic long-range memory latent within the dynamics of time series data may be temporally associated with extrinsic variables . Using the monthly number  FDA Center for Drug Evaluation and Research (CDER)
After revision:  Here, a novel approach, termed the Chronological Hurst Exponent (CHE), is proposed, which hypothesizes that changes in intrinsic long-range memory latent within the dynamics of time series data may be temporally associated with changes in such influences . Using the monthly number FDA Center for Drug Evaluation and Research (CDER)