Before revision:  We found that while ACE-I, DRI, rhACE2 and Ang1-7 tend to improve the clinical outcomes in a tension-dependent manner, the use of ARB appears to worsen it. The mathematical model that we developed offers the interesting possibility of testing in silico the RAS dysregulation upon SARS-CoV-2 infection and of predicting how risk factors as well as different drugs , alone or in combination, impact on RAS and disease severity .
After revision:  We found that while ACE-I, DRI, rhACE2 and a worsening for others .