Before revision:  Based on the patch-clamp experimental data obtained from the outer membranes of isolated nuclei of theXenopus oocyte, we construct an allosteric competition model of single IPR channels on their native ER membrane environment. In our model, each IPR channel consists of four subunits, each of which can exist in two configurations. Each subunit in both configurations has one IP_3 binding site, together with one activating and one inhibitory Ca^{2+ the well-known Monod-Wyman-Changeux allosteric model, we construct our model from the subunit level to the channel level  .
After revision:  Based on the patch-clamp experimental data obtained from the outer membranes of isolated nuclei of theXenopus oocyte, we construct an allosteric competition model of single IPR channels based on the well-known Monod-Wyman-Changeux allosteric model, we construct our model from the subunit level to the channel level .