Before revision:  However, the physical model explaining the critical role of multivalency for the histone code is still lacking. Here, we propose a theory that explains the energetic " payout " of multivalency in the formalism of statistical mechanics.
After revision:  However, as examples of multivalent histone engagement accumulate, an apparent contradiction is emerging. The isolated effector domains are notably weak binders, thus it is often asserted that the entropic cost of orienting multiple domains can be " payout " of multivalency in the formalism of statistical mechanics.