Before revision:  We further demonstrate the ability of these various methods to correctly predict pairings among actual paralogous proteins with genome proximity but no known direct physical interaction, which illustrates the importance of phylogenetic correlations in real data.
After revision:  Employing DCA or phylogenetic methods within an Iterative Pairing Algorithm (IPA) allows to predict pairs of evolutionary partners without a training set. We demonstrate the ability of these various methods to correctly predict pairings among actual paralogous proteins with genome proximity but no known direct physical interaction, which illustrates the importance of phylogenetic correlations in real data.