Before revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation , and decreasing methylation in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors for pluripotency.
After revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation . The decreasing methylation repressed by miRNAs in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors for pluripotency.