Before revision:  Our model rationalises a number of long-standing unexplained observations: we show that HIV integration is favoured in nucleosomal rather than naked DNA, and in flexible over rigid DNA. We find that these biases arise due to the difference in the bending energy barrier associated with DNA insertions.
After revision:  Our model rationalises a number of long-standing unexplained observations: we show that HIV integration is favoured within nucleosomal and flexible DNA, in line with experiments, and that these biases arise due to the difference in the bending energy barrier associated with DNA insertions.