Before revision:  We report that Tau depletion in neuroblastoma cells severely dysregulate P53 activity and leads to reduced cell death counterbalanced by increased cell senescence.
After revision:  We report that Tau depletion in neuroblastoma cells with depleted Tau, as a model of loss-of-function. Under these conditions, altered P53 activity and leads to reduced cell death counterbalanced by increased cell senescence.