Before revision:  In particular, when the system exhibits  large signal flow, the signaling proteins tend to surround the receptors  , and the target proteins tend to become distributed around the receptor--signaling protein clusters.
After revision:  In particular, when the system exhibits large signal flow, the signaling proteins tend to surround the receptors to form receptor-signaling protein clusters , and the target proteins tend to become distributed around the receptor--signaling protein clusters.