Before revision:  We show that gene expression differences between normal and cancer tissue are anticorrelated with local flux entropy changes, thus providing a systemic link between gene expression changes  and their local information flux dynamics. We also show that genes located in the intracellular domain demonstrate preferential increases in flux entropy, while the entropy of genes encoding membrane receptors and secreted factors is preferentially reduced. Thus, these results elucidate intrinsic network properties of cancer and support the view that the observed increased robustness of cancer cells to perturbation and therapy may be due to an increase in the dynamical network entropy allowing cells to adapt to extracellular stresses .
After revision:  We show that gene expression differences between normal and cancer tissue are anticorrelated with local flux entropy changes, thus providing a systemic link between gene expression changes and their local network dynamics. In particular, we also find that genes which drive cell-proliferation in cancer cells and which often encode oncogenes are associated with reductions in the dynamic network entropy. In summary, our results support the view that the observed increased robustness of cancer cells to perturbation and therapy may be due to an increase in the dynamical network entropy allowing cells to adapt to extracellular stresses .