Before revision:  As a consequence of DNA damage, abnormal modifications of both P53 and  MDM2 were detected in Tau-KO cells suggesting an important role of Tau in the regulation of P53 modification, stability and activity .
After revision:  As a consequence of DNA damage, abnormal modifications of both P53 and its E3 ubiquitin ligase MDM2 were detected in Tau-KO cells suggesting an important role of Tau in the regulation of P53 modification, stability and activity .