Before revision:  Importantly, they can also locally open a region of the genome that is collapsed due to self-interactions and "dive" deep into its core, strikingly enhancing the efficiency of target search on such an inaccessible substrate.
After revision:  Importantly, they can also locally open a region of the genome which is collapsed due to self-interactions and "dive" deep into its core, strikingly enhancing the efficiency of target search on such an inaccessible substrate.