Before revision:  A computational investigation to evaluate the relative binding ability of a group of anti- Angiopoietin-2 aptamersis proposed and tested against data already available in the literature. Results: The procedure consists of three steps: a. the production of a large set of conformations for each candidate aptamer ;
After revision:  A novel strategy is proposed to validate the reliability of the 3D structures of aptamers, produced in silico by using free software. The procedure consists of three steps: a. the production of a large set of conformations for each candidate aptamer ;