Before revision:  dependence of the mean open duration at high [IP_3], a steady-state behavior which fails to be correctly described in previous IPR models , and the adaptation of the IPR channel, an important dynamic behavior which is seldom discussed in previous IPR models. In addition, we find that the gating of the IPR channel is most likely to be a biochemical process that consumes energy.
After revision:  dependence of the mean open duration at high [IP_3], a steady-state behavior which fails to be correctly described in previous IPR models . Finally, we used the patch-clamp experimental data to validate that the IPR channel indeed breaks detailed balance and thus is a nonequilibrium system which consumes energy.