Before revision:  The data consist of time-course measurements of the immediate-early signaling of mitogen activated protein kinase (MAPK ), and phosphoinositide 3-kinase (PI3K)/Protein kinase B (AKT ). By respecting the multi-indexed structure of the experimental data, the analysis can be optimized for biological interpretation and therapeutic understanding.
After revision:  The data consist of time-course measurements of the early-signalling kinases MAPK and AKT at two different ligand dose levels. By imposing appropriate structural constraints and respecting the multi-indexed structure of the experimental data, the analysis can be optimized for biological interpretation and therapeutic understanding.