Before revision: Allosteric molecules serve as regulators of cellular activity across all domains of life . We present a general theory of allosteric transcriptional regulation that permits quantitative predictions for how physiological responses are tuned to environmental stimuli.
After revision: Allosteric molecules serve as regulators of cellular activity across all domains of life , yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response. To that end, we present a general theory of allosteric transcriptional regulation that permits quantitative predictions for how physiological responses are tuned to environmental stimuli.