Before revision:  Despite their ancient origins in the eukaryotic and mitochondrial primogenitors, we find that both clpB loci of Saccharomyces share a promoter signature that is specific to 7 genes involved in prion homeostasis. We suggest that the loss of these amyloid disaggregases was a necessary step in the evolutionary origin of the asymmetric cell specifications of somatic development .
After revision:  Despite their ancient origins in the stem-metazoan lineage. We further propose that key components of metabolic pathways may have required chaperone-mediated folding, and that loss of these amyloid disaggregases was a necessary step in the evolutionary origin of the asymmetric cell specifications of somatic development .