Before revision:  An initial investigation of the biological target system and the desired components as well as the definition of design objectivesincluding the functional mechanism are fundamental prerequisites. The subsequent computational design is needed to combine the selected components and to obtain novel functionality.
After revision:  An initial investigation of the biological target system and the desired components as well as the desired components in order to define design objectives. Subsequent computational design is needed to combine the selected components and to obtain novel functionality.