Before revision:  Autophagy selectivity must not only select the correct type URLanelle, but  must discriminate between URLanelles of the same kind . In the context of peroxisomes, we use computational models to explore the hypothesis that physical clustering of autophagy receptor proteins on the surface of URLanelle provides an appropriate all-or-none signal for degradation.
After revision:  Autophagy selectivity must not only select the correct type URLanelle, but must discriminate between URLanelles of the same kind so that some but not all of URLanelles are removed. We propose that physical clustering of autophagy receptor proteins on the surface of URLanelle provides an appropriate all-or-none signal for degradation.