Before revision:  While increasing the applied tip force from 6 to 12 nN did not significantly change the temperature dependence of ETp via apo-Az, ETp via holo-Az changed qualitatively, namely from temperature-independent at 6 nN to thermally activated at forces \geq 9 nN, suggesting changes in the protein structure upon increasing the applied force.
After revision:  While increasing the applied tip force from 6 to 12 nN did not significantly change the temperature dependence of ETp via apo-Az, ETp via holo-Az is temperature-independent at 6 nN to thermally activated at forces \geq 9 nN, suggesting changes in the protein structure upon increasing the applied force.