Before revision:  Real-time ocular responses in everyone are tightly associated with emotional state and cognitive processing in the brain. At the eyeball areas, at least changes involved saccades, pupil response, blinking, microvascular network morphology and thickness of retinal nerve fiber layer (RNFL) are potentially to be candidates of biomarker to screen and evaluate brain disorders. These days medical big data will be more accessible especially with the help of advanced artificial intelligence (AI) to analyze precisely.
After revision:  Real-time ocular responses in everyone are tightly associated with emotional state and cognitive processing within the central nervous system. Patterns seen in saccades, pupillary responses, and blinking, as well as retinal microvasculature and morphology visualized via office-based ophthalmic imaging, are potential biomarkers for the screening and evaluation of cognitive and psychiatric disorders. Additionally, rapid advances in artificial intelligence (AI) to analyze precisely.