Before revision:  We hypothesize that these protein interaction networks embody mechanisms and processes that are relevant in generic cancers and those specific to SBC, respectively. We , then, identified targets specific to SBC by combining key cancer-related genes , SBCGs and ontologically significant genes. These targets, apart from being ontologically relevant to SBC , are critical in the topology and dynamics of generic cancer mechanisms. Further, we refined the targets for SBC-specificity by filtering out the genes involved in primary bone cancer , any other type of cancer or any other known disease.
After revision:  We hypothesize that these protein interaction networks embody mechanisms and processes that are relevant in generic cancers and prostate cancers, is a challenge. Towards achieving our aim of identification of targets specific to SBC, we constructed a 'Cancer Genes Network', a representative protein interactome of cancer genes. Using graph theoretical methods, we obtained a set of key genes that are relevant for generic mechanisms of cancers and have a role in biological essentiality. We also compiled a curated dataset of 391 SBC genes involved in primary bone cancer , any other type of cancer or any other known disease.