Before revision:  On the other hand, there is significant empirical evidence, e.g. in network science and bioinformatics, that substructures are often informative for downstream tasks, suggesting that it is desirable to design GNNs capable of leveraging this important source of information .
After revision:  On the other hand, there is significant empirical evidence, e.g. in network science and bioinformatics, that substructures are often intimately related to downstream tasks .