Before revision:  To analyse the effects of spatial heterogeneity of the signalling processes, along with  ODE models we derive  PDE-ODE systems modelling the temporal and spatial dynamics of molecules involved in the signalling pathways.
After revision:  To analyse the effects of spatial heterogeneity of the signalling processes, along with spatially-homogeneous ODE models we derive PDE-ODE systems modelling the temporal and spatial dynamics of molecules involved in the signalling pathways.