Before revision:  In blind prediction mode, we present evolutionary couplings for 180 RNAs of unknown structure (available at URL  We anticipate that this approach will shed light on the structure and function of as yet less known RNA genes.
After revision:  In blind prediction mode, we present evolutionary couplings for 180 RNAs of unknown structure (available at URL and use these predictions to shed light on the mechanism of tRNA sensing by the T-box riboswitch, as well as the evolutionary history of the ribozyme RNase P. We anticipate that this approach will shed light on the structure and function of as yet less known RNA genes.