Before revision:  Then we used coupled single cell and population simulations to demonstrate that one can greatly reduce the time and the total amount of antibiotics needed to extinct a bacteria populationwith RA. We also suggested that RA can find application in other situations such as cancer radiotherapy .
After revision:  Then we used coupled single cell and population simulations to demonstrate that one can greatly reduce the time and the total amount of antibiotics needed to sterilize a bacterial population. We suggest that resonant activation is a general phenomenon in phenotypic transition, and can find other applications such as cancer radiotherapy .