Before revision: When exploring statistical properties of genetic sequences two main features stand out: the existence of non-random structures at various scales (e. g., long-range correlations ) and the presence of symmetries (e.g., Chargaff parity rules). In the last decades, numerous studies investigated the origin and significance of each of these features separately .
After revision: When exploring statistical properties of genetic sequences two main features stand out: the existence of non-random structures at different scales indicate a complex URLanisation. On the other hand, single-strand symmetry has been scrutinised using neutral models in which correlations are not considered or irrelevant, contrary to empirical evidence. Different studies investigated these two statistical features separately, reaching minimal consensus despite sustained efforts .