Before revision:  Algorithms have already been described that can correct movement of entire frames or large regions of frames at exposures of 2-3 e^{- rolling averages to be calculated from frames and fit linear trajectories for particles.
After revision:  Algorithms have already been described that can correct movement of entire frames or large regions of frames and for > 1 MDa protein particles. Another algorithm allows individual < 1 MDa protein particle trajectories to be estimated, but requires rolling averages to be calculated from frames and fit linear trajectories for particles.