Before revision:  Here, we address this issue for biomolecular systems using a combination of Monte Carlo simulations and experimental data, exploiting the dependence of the process noise , in the Langevin framework, on the states and parameters  .
After revision:  Here, we address this issue for biomolecular systems using a combination of Monte Carlo simulations and experimental data, exploiting the dependence of the process noise , in the Langevin framework, on the states and parameters , as given in the Langevin framework .