Before revision:  Extending earlier work by addressing the initial nucleation of NBR1 clusters on individual peroxisomes, we find that larger peroxisomes nucleate NBR1 clusters first and lose them due to competitive coarseninglast, resulting in significant size-selectivity favouring large peroxisomes. This effect can explain the increased catalase signal that results from experimental siRNA inhibition of p62.
After revision:  Extending earlier work by addressing the initial nucleation of NBR1 clusters on individual peroxisomes, we find that larger peroxisomes nucleate NBR1 clusters first and lose them due to competitive coarseninglast, resulting in significant size-selectivity that favors large peroxisomes, and can explain the increased catalase signal that results from experimental siRNA inhibition of p62.