Before revision:  This quantity or the hydration thermodynamics of a small molecule analog of the side-chain or some combination of such estimates, have anchored the interpretation of many of the seminal experiments on protein stability and folding and in the genesis of the current views on dominant interactions stabilizing proteins .
After revision:  This quantity or the hydration thermodynamics of a small molecule analog of the side-chain or some combination of such estimates, have anchored the interpretation of many of the seminal experiments on protein stability and folding .