Before revision: We report the use of synthetic vesicles formed by amphiphilic block copolymers in water (known as polymersomes) for encapsulating proteins, varying the vesicle size, and protein concentration. We show that confinement within polymersomes core corresponds to a liquid-liquid phase transition with the protein/water within  lumen interacting very differently than in bulk.
After revision: We report that protein confinement within nanoscopic vesicular compartments corresponds to a liquid-liquid phase transition with the protein/water within lumen interacting very differently than in bulk.