Before revision:   We illustrate the method for two compounds of increasing size and complexity : ethanol and 1-naphtol .
After revision:  A novel soft-core function applied to the overall solute-solvent interaction energy rather than individual interatomic pair potentials critical for this result is also presented. Because it does not require modifications of core force and energy routines, the soft-core formulation can be easily deployed in molecular dynamics simulation codes. We illustrate the method for two compounds of increasing size and complexity : ethanol and 1-naphtol .