Before revision:  For example, with an increase in the binding rate of target proteins to the membrane , the signal flow varies in the form i) monotonically increasing , ii) increasing then decreasing in a bell-shaped curve , or iii) increasing, decreasing then, increasing in an S-shaped curve.
After revision:  For example, with an increase in the binding rate of target proteins , the signal flow varies in the form i) monotonically increasing , ii) increasing then decreasing in a bell-shaped curve , or iii) increasing, decreasing then, increasing in an S-shaped curve.