Before revision:  We then develop biophysical models of paired spike trains to reproduce the phenomenology of monosynaptic interactions observed in those data , including both fine-timescale spike-spike correlations and the irregular firing found in vivo . We use simulated data generated from these biophysical models to study the inference of small synaptic changes from spike data, despite the presence of rapidly-varying background network fluctuations.
After revision:  We then develop biophysical models of paired spike trains to reproduce the phenomenology of monosynaptic interactions observed in those data , including both fine-timescale spike-spike correlations and the irregular firing found in vivo  We use simulated data generated from these biophysical models to study the inference of small synaptic changes from spike data, despite the presence of rapidly-varying background network fluctuations.