Before revision:  The methodology can be applied in the absence of a specific biological context by modelling fluxes probabilistically, or can be tailored to different environmental conditions by incorporating flux distributions computed from constraint-based modelling such as Flux Balance Analysis.
After revision:  The methodology can be applied in the absence of a specific biological context by modelling fluxes probabilistically, or can be tailored to different environmental conditions by incorporating flux distributions computed from constraint-based approaches such as Flux Balance Analysis.