Before revision:  Vessels sprouting was tracked for 3 weeks and with increasing time exhibited formation of multiple vessel sprouts that invaded into the ECM and surrounded clusters of MDA-IBC3 cells . Both IBC cell lines, SUM149 and MDA-IBC3, resulted in a collagen ECM with significantly greater porosity with 1.6 and 1.1 fold higher compared to control, p<0.01. The breast cancer in vitro vascularized platforms introduced in this paper are an adaptable, high throughout tool for unearthing tumor-stromal mechanisms and dynamics behind tumor progressionand may prove essential in developing effective targeted therapeutics .
After revision:  Vessels sprouting was tracked for 3 weeks and with increasing time exhibited formation of multiple vessel sprouts that invaded into the ECM and surrounded clusters of MDA-IBC3 cells replicating a feature of in vivo IBC. The IBC in vitro vascularized platforms introduced in this paper are an adaptable, high throughout tool for unearthing tumor-stromal mechanisms and dynamics behind tumor progressionand may prove essential in developing effective targeted therapeutics .