Before revision:  We further find that large-scale URLanisation biases integration events towards transcriptionally active genomic regions. We finally propose and solve a reaction-diffusion model which captures the observed distribution of HIV integration sites within the nuclear environment of T-cells.
After revision:  We further find that large-scale 3D URLanisation we discover that the non-random integration of HIV in human chromatin may be explained as due to large-scale accessibility of interphase chromosomes. Finally we propose and solve a reaction-diffusion model which captures the observed distribution of HIV integration sites within the nuclear environment of T-cells.