Before revision:  The RDME has been shown to have the drawback of losing bimolecular reactions in the limit that the lattice spacing approaches zero ( in two or more dimensions ).
After revision:  The RDME has been shown to have the drawback of losing bimolecular reactions in the limit that the lattice spacing approaches zero ( in two or more dimensions , the RDME has been shown to lose bimolecular reactions. The RDME is therefore not a convergent approximation to any spatially-continuous model that incorporates bimolecular reactions.