Before revision:  We find that regardless of the network parameters , the biochemical network can never reach the thermodynamic limit of efficiency, and faces a tradeoff between accuracy and dissipation that is more severe than and qualitatively distinct from the tradeoff required thermodynamically . We conclude by demonstrating how biomolecules can be used to achieve optimal protocols -- not under the control of a steady-state biochemical network, but rather under the control of exogenously manipulated baths of ATP and ADP.
After revision:  We find that regardless of the network parameters , the biochemical network can never reach the thermodynamic limit of efficiency, and faces a tradeoff between accuracy and dissipation that is more severe than and qualitatively distinct from the tradeoff required thermodynamically and worse than implied by the bound, and more complex steady-state biochemical network, but rather under the control of exogenously manipulated baths of ATP and ADP.