Before revision: Topological constraints can affect both equilibrium and dynamics of polymer systems, and can play a role in URLanization in the cell. Despite of many theoretical conjectures, effects of topological constraints on  a single compact polymer have not been systematically studied.
After revision: Topological constraints can affect both equilibrium and dynamics of polymer systems, and can play a role in URLanization of chromosomes. Despite many theoretical studies, the effects of topological constraints on a single compact polymer have not been systematically studied.