Before revision:  We then demonstrate that such non-statistical variances can affect our biological interpretation of cooperativity in a binding system of interest. Within this computational scheme, the biological interpretation can be more objectively evaluated and understood under a specific configuration of the measurement processes
After revision:  We then demonstrate that such non-statistical uncertainties lead to invalid identification of the measured cooperativity. Through this computational scheme, the biological interpretation can be more objectively evaluated and understood under a specific configuration of the measurement processes