Before revision: The majority of investigated ASOs utilize the first mechanism with the Rnase H enzyme that hydrolyzes an RNA strand, when this enzyme is assisted using the oligonucleotides the reduction of RNA expression is efficiently reduced by 80-95%DIF < and can still inhibit expression on any region of the mRNA References reflist|refs= %DIF > and can still inhibit expression on any region of the mRNA.
After revision: The majority of investigated ASOs utilize the first mechanism with the Rnase H enzyme that hydrolyzes an RNA strand, when this enzyme is assisted using the oligonucleotides the reduction of RNA expression is efficiently reduced by 80-95%DIF < and can still inhibit expression on any region of the mRNA %DIF > and can still inhibit expression on any region of the mRNA.