Before revision:  The model explains how the histone-mediated signalling may rely upon weak individual histone-effector affinities while maintaining high probabilities for simultaneous binding of multiple partners and introduces an entropic "lock-and-key" as a critical component of the histone code .
After revision:  An all-atom molecular dynamics study of a relevant biological system involving the multivalent chromatin effector UHRF1 and its target histone H3 demonstrate that this interaction conforms to the conditions for an optimal free-energy payout, as predicted by the model .