Before revision: Definitions r = recombination frequency d = mean number of crossovers on a chromosomal interval 2d = mean number of crossovers for a tetrad e-2d = probability of no genetic exchange in a chromosomal interval Formula Based on the definitions, Mather's formula can be used to derive the Haldane mapping function as: Inverse Kosambi mapping function Overview The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency.
After revision: Definitions r = recombination frequency d = mean number of crossovers on a chromosomal interval 2d = mean number of crossovers for a tetrad e-2d = probability of no genetic exchange in a chromosomal interval Formula Based on the definitions, Mather's formula can be used to derive the Haldane Mapping Function as: Inverse Kosambi mapping function Overview The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency.