Before revision:  They exhibit a non-vanishing strain-twist coupling, which depends on the local geometry, i.e. on curvature and torsion, yet the paths of closed loops are restricted by White's theorem. We suggest that the reciprocation of these principles leads to a twist neutrality condition . I.e. to a zero sum rule for the incremental change in the rate of winding along the curve  .
After revision:  They exhibit a non-vanishing strain-twist coupling, which depends on the local geometry, i.e. on curvature and torsion, yet the paths of closed molecules are globally restricted by topology. Molecules that fulfill a twist neutrality condition . I.e. to a zero sum rule for the incremental change in the rate of winding along the curve .