Before revision:  An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its walls and is used to test whether such features might contribute to the proposed role of the microtubule as a mediator in intracellular signaling . Based on the results of Brownian dynamics simulations, the nanopores were found to have asymmetric inner and outer conductances, manifested as nonlinear IV curves.
After revision:  An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its walls and is used to study how ionic conductance along the lumen is affected by flux through the nanopores when an external potential is applied across its two ends . Based on the results of Brownian dynamics simulations, the nanopores were found to have asymmetric inner and outer conductances, manifested as nonlinear IV curves.