Before revision: Several studies pointed out the relevance of extrinsic noise in molecular networks in shaping cell decision making and differentiation . Interestingly, bimodal distributions of gene expression levels, that may be a feature of phenotypic differentiation, are a common phenomenon in gene expression data.
After revision: Several studies pointed out the relevance of extrinsic noise in molecular networks in shaping cell decision making and differentiation in molecular networks. Experimental evidences of phenotypic differentiation are given by the presence of bimodal distributions of gene expression levels, that may be a feature of phenotypic differentiation, are a common phenomenon in gene expression data.