Before revision:  We then apply this model and descriptors to the analysis of the communication effects produced by inhibitors of the main protease of COVID-19 . We find that the perturbation produced by strong inhibitors of the protease are propagated up to 60 \AA away from the binding site, confirming the long-range nature of intra-protein communication  .
After revision:  We then apply this model and descriptors to the analysis of the communication effects produced by inhibitors of the main protease of COVID-19 . We find that the perturbation produced by strong inhibitors of the protease are propagated up to 60 \AA away from the binding site, confirming the long-range nature of intra-protein communication . On the contrary, the weakest inhibitors only transmit their perturbations across a close environment around the binding site .