Before revision:  We present a general theory of allosteric transcriptional regulation that permits quantitative predictions for how physiological responses are tuned to environmental stimuli. To test the model 's predictive power, we apply it to the specific case of the ubiquitous simple repression motif in bacteria .
After revision:  We present a general theory of allosteric transcriptional regulation using the Monod-Wyman-Changeux model. We rigorously test this model using the ubiquitous simple repression motif in bacteria .