Before revision:  Here we have developed a methodology that allowed us to quantify the effective contribution of each module to the overall cascade's ultrasensitivity and to determine the impact of sequestration effects in the overall system's ultrasensitivity .
After revision:  Here we introduced a methodology that allowed us to quantify the effective contribution of each module to the overall cascade's ultrasensitivity and to determine the impact of sequestration effects in the overall system's ultrasensitivity .