Before revision:  We suggest that this mechanism potentially explains the motif of a coherent feed-forward loop terminating in overlapping binding sites commonly found in developmental networks , and discuss three specific examples. The systematic method proposed herein can be used to shed light on TF cross-regulation networks either from direct measurements of binding noise, or bioinformatic analysis of overlapping binding sites .
After revision:  We suggest that this mechanism potentially explains the motif of a coherent feed-forward loop terminating in overlapping binding sites commonly found in developmental networks , and discuss generalizations to other signaling pathways. Our results challenge the conventional approach of treating biological noise as uncorrelated fluctuations, and present a systematic method for understanding TF cross-regulation networks either from direct measurements of binding noise, or bioinformatic analysis of overlapping binding sites .