Before revision:  Overall, this study demonstrates that tauRAMD combines both computational efficiency and the ability to capture the main features determining the relative dissociation rates, thus providing insights that could be exploited in drug design .
After revision:  Overall, this study demonstrates that tauRAMD combines both computational efficiency and the ability to capture the main features determining the relative dissociation rates, thus providing insights that could be exploited in the rational optimization of the kinetic properties of drug candidates .