Before revision:  However, most existing similarity-based methods follow the transductive setting. These methods cannot directly generalize to unseen data because they should be re-built to predict the interactions for new arriving drugs , targets, or drug-target pairs.
After revision:  However, most existing similarity-based methods need to be re-trained to predict interactions for any new drugs or targets and cannot directly perform predictions for both new drugs, new targets, and new drug-target pairs.