Before revision:  The proposed approach is  applied to three different case studies: Two prevalent diseases , Lung Cancerand Dementia, for which a lot of knowledge is available, and one rare disease, Duchenne Muscular Dystrophy , for which knowledge is less abundant and difficult to locate.
After revision:  The proposed approach is implemented as an open-source framework and applied to three different case studies: Two prevalent diseases , Lung Cancerand Dementia, for which a lot of knowledge is available, and one rare disease, Duchenne Muscular Dystrophy , for which knowledge is less abundant and difficult to locate.