Before revision:  Prior research lacks the investigation of how machine learning can be applied to a big-data platform to ensure an informed  and judicious prescribing of opioids . In this study , we explore the Massachusetts All Payer Claim Data(MA APCD) , a de-identified healthcare claim dataset, and propose a novel framework to examine how na\"ive users develop opioid use disorder.
After revision:  Prior research lacks the investigation of how machine learning can be applied to a big-data platform to ensure an informed and judicious prescribing of opioids , in particular for commercially insured population. This study explores Massachusetts All Payer Claim Data(MA APCD) , a de-identified healthcare claim dataset, and propose a novel framework to examine how na\"ive users develop opioid use disorder.