Before revision:  By reliably and rapidly narrowing down target interactions,  our predictions can inform and reduce the time spent on more computationally intensive in-silico analyses, and time-consuming in-vitro and in-vivo experiments  .
After revision:  By reliably and rapidly narrowing down target interactions, (no more than 1.5 hours per interface on a laptop with Intel Core i5-2500K 3.2Ghz CPU and 8GB of RAM) our predictions can inform and reduce the time spent on more computationally intensive in-silico analyses, and time-consuming in-vitro and in-vivo experiments .