Before revision: The Haybittle–Peto boundary is one such stopping rule, and it states that if an interim analysis shows a probability of less than 0.001 that a difference as extreme or more between the treatments is found, given that the Null-hypothesis is true, then the trial should be stopped early.
After revision: The Haybittle–Peto boundary is one such stopping rule, and it states that if an interim analysis shows a probability of less than 0.001 that a difference as extreme or more between the treatments is found, given that the null hypothesisequal to, or is true, then the trial should be stopped early.