Before revision: The effect of this hyperexcitability is thought to be an increase in the amount of GABA release from the NAc on the ventral tegmental area (VTA), making the dopaminergic neurons in the VTA less likely to fire, and thus resulting in the symptoms of withdrawal.
After revision: The effect of this hyperexcitability is thought to be a decrease in the amount of GABA release from the NAc on the ventral tegmental area (VTA), making the dopaminergic neurons in the VTA less likely to fire, and thus resulting in the symptoms of withdrawal.