Before revision:  We compare the performance of this framework with different fixed values of process noise covariance in biomolecular system models, including an oscillator model, as well as in experimentally measured growth rate of E. coli, finding that it has a similar performance with the advantage that the noise covariance does not have to be guessed .
After revision:  We compare the performance of this framework with different fixed values of process noise covariance in biomolecular system models, including an oscillator model, as well as in experimentally measured data for a negative transcriptional feedback circuit .