Before revision:  Incorporating this catchbonding behavior of dynein in a theoretical model and using experimentally relevant measures characterizing cargo transport , we show that the functional divergence of the two motors species manifests itself as an internal regulatory mechanism for bidirectional transport and resolves the paradox of codependence. Our model reproduces the key experimental features in appropriate parameter regimes and provides an unifying framework for bidirectional cargo transport .
After revision:  Incorporating this catchbonding behavior of dynein in a theoretical model and using experimentally relevant measures characterizing cargo transport , we show that the functional divergence of the two motors species manifests itself as an internal regulatory mechanism , and leads to codependent transport behaviour in biologically relevant regimes. Using analytical methods and stochastic simulations, we analyse the processivity characteristics and probability distribution of run times and pause times of transported cellular cargoes. We show that catchbonding can drastically alter the transport characteristics and also provide a plausible resolution of the paradox of codependence .