Before revision:  Further, we refined the targets for SBC-specificity by filtering out the genes involved in primary bone cancer , any other type of cancer or any other known disease. Our composite rational strategy involving literature-mined experimental data, graph theoretical analysis and gene ontological studies predicts targets that are more specific and relevant for SBC .
After revision:  Further, we refined the targets for SBC-specificity by filtering out the genes involved in primary bone cancer , SBC genes and gene ontology enrichment method, to obtain a set of targets that are specific to bone metastasis. Through this study, we present an approach for probing one of the major complications in cancers, namely, metastasis. The results on genes that play generic roles in cancer phenotype, obtained by network analysis of 'Cancer Genes Network', have broader implications in understanding the role of molecular regulators in mechanisms of cancers. Specifically, our study provides a set of potential targets that are more specific and relevant for SBC .