Before revision:   Second, although the static co-crystal structure shows two large hydrogen-bonding networks in the GP1/hTfR1 interface, our simulations indicate that only one of them is critical for the bindinginteraction .
After revision:  Second, although the static co-crystal structure shows two large hydrogen-bonding networks in the GP1/hTfR1 interface, our simulations indicate that only one of them may not be important for tight binding .