Before revision: Nature uses combinatorial control strategies that are different from those used by present pharmacological approaches for controlling disease. Function and differentiation of cells URLanisms are naturally regulated by control networks that are bipartite, i.e. contain two different types of nodes: controllers and targets. Each controller acts on many targets, and target nodes are controlled by many controllers in a strongly overlapping many-to-many network structure.
After revision: Cells are regulated by networks of controllers having many targets, and target nodes are controlled by many controllers in a strongly overlapping many-to-many network structure.