Before revision: Mathematical models are increasingly being used to understand complex biochemical systems, but we rarely know the consequences of choosing one modelto another . Using algebraic techniques we study systematically the effects of intermediate (transient) complexes and provide a simple, yet rigorous mathematical classification of all models obtained from a core model by including intermediates.
After revision: Mathematical models are increasingly being used to understand complex biochemical systems, but we rarely know how robust our conclusions are with respect to the choice and uncertainties of the model . Using algebraic techniques we study systematically the effects of intermediate (transient) complexes and provide a simple, yet rigorous mathematical classification of all models obtained from a core model by including intermediates.