Before revision:  Therefore, it has been suggested that larger intrinsic noise enables more robust information transmission against the extrinsic noise, which is called `` intrinsic noise-induced robustness (INIR) '' . However,  it is unclear whether INIR universally appears in various biochemical reactionsbecause previous studies focused on the specific biochemical reactions .
After revision:  Therefore, it has been suggested that larger intrinsic noise enables more robust information transmission against the extrinsic noise, which is called `` intrinsic noise-induced robustness (INIR) '' . However, it is unclear whether INIR appears universally in biochemical reactions .