Before revision:  In this study, the number of cross-links and their discriminative power was systematically analyzed in silico on a set of 2,055 non-redundant protein folds considering Lys-Lys, Lys-Asp, Lys-Glu, Cys-Cys, and Arg-Arg reactive cross-linkers between 1 \r{A and 60 \r{A . Depending on the protein size a heuristic was developed that determines the optimal cross-linker length.
After revision:  In this study, the number of cross-links and their discriminative power was systematically analyzed in silico on a set of 2,055 non-redundant protein folds considering Lys-Lys, Lys-Asp, Lys-Glu, Cys-Cys, and Arg-Arg reactive cross-linkers between 1 \r{A and 60 \AA . Depending on the protein size a heuristic was developed that determines the optimal cross-linker length.