Before revision:  Over the last years, it has been well established that coevolution is essential also in proteins for maintaining three-dimensional structure and function ; modeling approaches based on inverse statistical physics can catch the coevolution signal and are now widely used in predicting protein structure, protein-protein interactions, and mutational landscapes.
After revision:  Over the last years, it has been well established that coevolution is essential also in proteins for maintaining three-dimensional structure and function . Modeling approaches based on inverse statistical physics can catch the coevolution signal and are now widely used in predicting protein structure, protein-protein interactions, and mutational landscapes.