Before revision: In  Coronavirus disease 2019 (COVID-19), the initial viral replication phase is often followed by a hyperinflammatory reaction in the lungs and URLan systems ('cytokine storm syndrome') that leads to acute respiratory distress syndrome (ARDS), URLan failure, and death- despite maximal supportive care.
After revision: In severe pneumonias, including Coronavirus disease 2019 (COVID-19), the initial viral replication phase is often followed by a hyperinflammatory reaction in the lungs and URLan systems ('cytokine storm syndrome') that leads to acute respiratory distress syndrome (ARDS), URLan failure, and death- despite maximal supportive care.