Before revision:  This choice, typically made by what is known as Direct Coupling Analysis, has been highly successful in using sequences for predicting residue contacts in the three-dimensional structure, mutational effects, and in generating new functional sequences.
After revision:  This choice, typical of what is known as Direct Coupling Analysis, has been highly successful in using sequences for predicting residue contacts in the three-dimensional structure, mutational effects, and in generating new functional sequences.