Before revision:  SA was found to be capable of reliably identifying the optimal arrangement of arteries to supply the heart. In this paper, we extract volumes representing the gray and white matter of the brain from Magnetic Resonance Imaging (MRI) data and automatically generate the optimal arterial tree using simulated annealing .
After revision:  SA was found to be capable of reliably identifying the optimal arrangement of arteries to identify the ideal configuration of arteries required to sustain an entire brain hemisphere based on minimisation of the energy required to supply the tissue. The 3D distribution of grey and white matter of the brain from Magnetic Resonance Imaging (MRI) data and automatically generate the optimal arterial tree using simulated annealing .