Before revision:  To address this issue, we formulate a generic physical model where we treat the viral incorporation into DNA and chromosomes as a stochastic quasi-equilibrium  process.
After revision:  To address this issue, we formulate a generic physical model where we treat the viral incorporation into DNA and chromosomes as a stochastic quasi-equilibrium topological reconnections between polymers. We discover that physical effects, such as DNA accessibility and elasticity, play important and universal roles in this process.