Before revision:  Here we have developed a methodology that allowed us to quantify the effective contribution of each module to the overall cascade's ultrasensitivity and to determine the impact of sequestration effects in the overall system's ultrasensitivity .
After revision:  Here we have developed a methodology that allowed us to determine the presence of sequestration effects and to quantify the relative contribution of each module to the overall cascade's ultrasensitivity and to determine the impact of sequestration effects in the overall system's ultrasensitivity .