Before revision:   We investigate the mechanism of peeling of the histone spool, and its complete detachment, from the dsDNA by a CRE  . Our two-state model of a CRE captures effectively two distinct chemical (or conformational) states in the mechano-chemical cycle of each ATP-dependent CRE.
After revision:  We investigate the mechanism of peeling of the histone spool, and its complete detachment, from the dsDNA by a CRE that translocates along the dsDNA . Our two-state model of a CRE captures effectively two distinct chemical (or conformational) states in the mechano-chemical cycle of each ATP-dependent CRE.