Before revision:  We find that synthetic lethal interactions and their classification in plasticity and redundancy are basically insensitive to minimal medium composition, and are highly conserved even when the environment is enriched with nonessential compounds  .
After revision:  We find that synthetic lethal interactions and their classification in plasticity and redundancy are basically insensitive to minimal medium composition, and are highly conserved even when the environment is enriched with nonessential compounds or overconstrained to decrease maximum biomass formation .