Before revision:  Despite that, well-known problems such as low sensitivity, dominance of false positives, the accurate reconstruction of long-range connections could not be avoided or minimized. Current methods include several parameters, typically tuned in a heuristic way, with settings to increase the sensitivity, without attenuating the overall problem.
After revision:  Despite that, well-known problems such as low sensitivity, dominance of false positives, the accurate reconstruction of long-range connections . Furthermore, parameters of tracking algorithms are typically tuned in a heuristic way, with settings to increase the sensitivity, without attenuating the overall problem.