Before revision:  In a minimal model of pleiotropic receptor cross-talk, we show that a single pleiotropic receptor is sufficient to simultaneously identify the ligand and accurately sense the concentration of a presented ligand, enabling specific and accurate signaling .
After revision:  In a minimal model of pleiotropic receptor cross-talk, we show that a single pleiotropic receptor is sufficient to simultaneously identify the ligand and accurately sense the concentrations of arbitrary unknown ligands present individually or in a mixture .