Before revision:  To better understand the relationship between the virus and its human host, we used a structure-based computational model to interrogate the effects of mutations in the interfacebetween the MACV spike glycoprotein ( MACVGP) and the Human transferrin receptor (hTfR1) . Existing computational methods to probe protein-protein interactions perform poorly with non-alanine mutations and on the flexible loops encountered in many host-virus interactions.
After revision:  To better understand the relationship between the virus and its human host, we used a structure-based computational model to interrogate the effects of mutations in the interfacebetween the MACV spike glycoprotein ( GP1) away from the human transferrin receptor (hTfR1) . Existing computational methods to probe protein-protein interactions perform poorly with non-alanine mutations and on the flexible loops encountered in many host-virus interactions.