Before revision:  Self-regulating systems may be predictive of unwanted drug interference effects, since they aim to mimic complex cellular adaptation in a unified way.
After revision:  We also discuss the relationship between signaling with and without transients. Signaling by transients may involve maximization of signal transmission efficiency for the peak response, but a minimization in steady-state responses. With an appropriate objective function, this can also be achieved by concentration adjustment. URLanizing systems may be predictive of unwanted drug interference effects, since they aim to mimic complex cellular adaptation in a unified way.