Before revision:  In models characterized by a single copying step, we demonstrate thatthese modes are alternative, i.e. they cannot be mixed to further reduce the minimum error . However, the two modes can be combined in multi-step reactions, such as in models implementing error correction through a proofreading pathway.
After revision:  In models characterized by a single copying step, we demonstrate thatthese modes are alternative, i.e. they cannot be mixed to further reduce the error fraction. Close to the lowest error limit, kinetic discrimination results in a diverging copying velocity and dissipation per copied bit. On the opposite, energetic discrimination reaches its lowest error limit in an adiabatic regime where dissipation and velocity vanish.