Before revision: The best known cases of vaccine resistance are for the following diseases animal diseases Marek's disease where actually more virulent strains emerged after vaccination because the vaccine did not protect against infection and transmission, only against serious forms of the disease Yersinia ruckeri because a single mutation was sufficient to generate vaccine resistance avian meatpneumovirus human diseases Streptococcus pneumoniae because recombination with another serotype not targeted by the vaccine hepatitis B virus because the vaccine targeted a single site formed by 9 amino acids Bordetella pertussis because not all serotypes were targeted and later because acellular vaccines targetd only a few antigens Other less documented cases are for avian influenza, avian reovirus, Corynebacterium diphtheriae, feline calicivirus, H. influenzae, infectious bursal disease virus, Neisseria meningitidis, Newcastle disease virus, and porcine circovirus type 2.
After revision: The best known cases of vaccine resistance are for the following diseases animal diseases Marek's disease where actually more virulent strains emerged after vaccination because the vaccine did not protect against infection and transmission, only against serious forms of the disease Yersinia ruckeri because a single mutation was sufficient to generate vaccine resistance avian meatpneumovirus human diseases Streptococcus pneumoniae because recombination with another serotype not targeted by the vaccine hepatitis B virus because the vaccine targeted a single site formed by 9 amino acids Bordetella pertussis because not all serotypes were targeted and later because acellular vaccines targeted only a few antigens Other less documented cases are for avian influenza, avian reovirus, Corynebacterium diphtheriae, feline calicivirus, H. influenzae, infectious bursal disease virus, Neisseria meningitidis, Newcastle disease virus, and porcine circovirus type 2.