Before revision: A total of 15,792 middle-aged (45–64 years) men and women were enrolled from four U.S. communities: Forsyth County, North Carolina Jackson, Mississippi Suburbs of Minneapolis, Minnesota Washington County, Maryland
After revision: Participating organizations include four field centers (Wake Forest Baptist Medical Center, University of Mississippi Medical Center, University of Minnesota, Johns Hopkins University), data coordinating center (University of North Carolina at Chapel Hill), and many collaborating centers and laboratories.A total of 15,792 middle-aged (45–64 years) men and women were enrolled from four U.S. communities: Forsyth County, North Carolina Jackson, Mississippi Suburbs of Minneapolis, Minnesota Washington County, Maryland