Before revision: Computerized models of the cerebral vasculature are becoming increasingly used for analysis of medical images, patient treatment planning and cerebral haemodynamics simulations. Previously, we presented a method based on universal physical and physiological principles for the growth of realistic arterial trees in-silico using simulated annealing (SA). SA was found to be capable of reliably identifying the optimal arrangement of arteries to supply the heart.
After revision: The cerebral arteries are difficult to reproduce from first principles, featuring interwoven territories, and intricate layers of grey and white matter with differing metabolic demand. The aim of this study was to supply the heart.