Before revision:  Furthermore, homology class number and size have a high degree of universality, depending on genome size only and not on genome-specific features. These "genomic laws" can be regarded as evolutionary constraints on the growth mechanism of genomes. We define a statistical model describing the joint growth of the network and the partitioning of nodes into homology classesunder the constraint of a stochastic class-expansion/innovation model based on the "Chinese restaurant process", and we study this model through a combined mean-field and simulation approach.
After revision:  Proteins added to the network correspond to genes added to the classes, so that the dynamics of the two objects are intrinsically linked. Here, we first introduce a statistical model describing the joint growth of the network and the partitioning of nodes into homology classesunder the constraint of a stochastic class-expansion/innovation model based on the "Chinese restaurant process", and we study this model through a combined mean-field and simulation approach.