Before revision:  This article presents a "stepwise ansatz" for recursively enumerating a physically realistic subspace of protein conformations, implemented as a stepwise assembly (SWA) protocol in the Rosetta framework. For 32 of 40 loops that challenged prior approaches, at least one of five lowest energy SWA models agrees with the crystallographic conformation with C \alpha RMSD accuracy better than 1.0 \AA . SWA successes include hairpin-like loops , cis-Pro touch turns, loops with lengths of up to 24 residues (well outside the range of previous methods), and five blind tests:
After revision:  This article presents a "stepwise ansatz" for recursively enumerating a physically realistic subspace of protein conformations, implemented as a stepwise assembly (SWA) protocol \alpha RMSD accuracy better than 1.0 \AA . SWA successes include hairpin-like loops , cis-Pro touch turns, loops with lengths of up to 24 residues (well outside the range of previous methods), and five blind tests: