Before revision:  In particular, we show how the affinity of ligand-receptor binding can be largely varied by various oligomer formations in the low concentration range of G-protein stimulus . More broadly, our work provides concrete modeling principles to explore general relations between receptor aggregation and various signaling properties .
After revision:  In particular, we show how the affinity of ligand-receptor binding can be largely varied by various oligomer formations in the low concentration range of G-protein stimulus .