Before revision:  Many drugs were identified with downstream inhibition of these signaling pathways and GOs, and many of which are currently undergoing clinical trial evaluation. The analysis results can be potentially helpful to facilitate the future clinical trial design.
After revision:  Many drugs were identified with downstream inhibition of these signaling pathways and GOs, a set of potentially effective drugs were repurposed by integrating the drug-target and reverse gene expression data resources. The dexamethasone was top-ranked in the prediction, which was the first reported drug to be able to significantly reduce the death rate of COVID-19 patients receiving respiratory support. The results can be potentially helpful to facilitate the future clinical trial design.