Before revision:  We further demonstrated that molecular crowding influences the hierarchical molecular distributions throughout the reaction process. The signaling proteins tend to surround the receptors, and the target proteins tend to become distributed around the signaling protein-receptor clusters.
After revision:  We further demonstrated that molecular crowding influences the hierarchical molecular distributions throughout the reaction processes. In particular, when the system exhibits large signal flow, the signaling proteins tend to surround the receptors, and the target proteins tend to become distributed around the signaling protein-receptor clusters.