Before revision:  We conclude by demonstrating how biomolecules can be used to achieve optimal protocols -- not under the control of a steady-state biochemical network, but rather under the control of exogenously manipulated baths of ATP and ADP. This leads to an experimental system that might be used to test theories on the thermodynamicsof computation .
After revision:  We conclude by demonstrating how biomolecules can be used to achieve optimal protocols -- not under the control of a steady-state copy processes cannot perform better. Nonetheless, the cost remains close to the thermodynamic bound unless accuracy is extremely high. Additionally, we show that biomolecular reactions could be used in thermodynamically optimal devices under exogenous manipulation of chemical fuels, suggesting an experimental system that might be used to test theories on the thermodynamicsof computation .