Before revision: The pathophysiology of this disease resolves around a disconnect between the insular cortex secondary to damage and the limbic system, specifically the cingulate gyrus who's prime response to the pain perceived by insular cortex is to tether it with an agonizing emotional response thus signalling the individual of its propensity to inflict harm actual harm.
After revision: The pathophysiology of this disease resolves around a disconnect between the insular cortex secondary to damage and the limbic system, specifically the cingulate gyrus whose prime response to the pain perceived by insular cortex is to tether it with an agonizing emotional response thus signalling the individual of its propensity to inflict as proposed by VS Ramachandran, actual harm.