Before revision:  Most registration algorithms are designed for high-resolution research-quality scans and under-perform when applied to clinical data. Clinical scans present unique challenges because, in contrast to research-quality scans, clinical scans are often sparse, missing up to 85 \% of the slices available in research scans.
After revision:  Most registration algorithms are designed for high-resolution research-quality scans . In contrast to research-quality scans, clinical scans are often sparse, missing up to 85 \% of the slices available in research scans.