Before revision:  This work, together with the recent study by Hannanta-anan and Chow, suggests a ]  plausible mechanism for IP3-dependent hypertrophic signalling in cardiomyocytes.
After revision:  This work, together with the recent study by Hannanta-anan and Chow, suggests a ] plausible mechanism for IP3-dependent hypertrophic signalling via Ca2+-sensitive transcription factors such as NFAT in ventricular cardiomyocytes.