Before revision:  By compiling a set of available thermodynamic data for processes ranging from protein folding to protein-protein interactions, we show that excluded cosolutes can act through different mechanisms that correlate to a large extent with their molecular properties.
After revision:  By compiling a set of available thermodynamic data for processes ranging from protein folding to protein-protein interactions, we show that excluded cosolutes can act through two distinct mechanisms that correlate to a large extent with their molecular properties.