Before revision:  We validate the biological significance of the pol-II promoter activity clusters by investigating cluster-specific transcription factor binding patterns and determining canonical pathway enrichment  .
After revision:  We validate the biological significance of the pol-II promoter activity clusters by investigating cluster-specific transcription factor binding patterns and determining canonical pathway enrichment . We find that rapidly induced genes are enriched for both estrogen receptor alpha (ER\alpha) and FOXA1 binding in their proximal promoter regions .