Before revision: - a recipe that is consistent with recent experimental findings 1,2 . Moreover, we show that the specificity of memory should depend on URLanism's lifespan, and URLanisms with fewer pathogenic encounters throughout their lifetime should store more cross-reactive memory.
After revision: - a recipe that is consistent with recent experimental findings to balance between affinity and cross-reactivity of immune receptors for an effective protection against evolving pathogens . Moreover, we show that the specificity of memory should depend on URLanism's lifespan, and URLanisms with fewer pathogenic encounters throughout their lifetime should store more cross-reactive memory.