Before revision:  Label all atoms of hydrophobicity degree i by H_i and let M_\bX be the molecular surface for the conformation , defining M_{\bX_i as the set of points in M_\bX that are closer to atoms in H_i than any atoms in H_j, j } i. Then the geometric version of G( ) resembles to well-known surface area models , plus a volume term:
After revision:  Label all atoms of hydrophobicity degree i by H_i and let M_\bX be the molecular surface for the conformation , defining M_{\bX_i as the set of points in M_\bX that are closer to atoms in H_i than any atoms in H_j, j } i. Then the geometric version of G( For simplicity, only monomeric self folding globular proteins are covered. We point out some immediate applications of the formula. We show that the formula explains the observed phenomena very well. It gives a unified explanation to both folding and denaturation; it explains why hydrophobic effect is the driving force of protein folding and clarifies the role played by hydrogen bonding; it explains the successes and deficients of various surface area models , plus a volume term: