Before revision:  In particular, cells have been shown to reorient under such perturbations, aligning at specific angles with respect to the stretching direction that depends strongly on the type of cell . We introduce a computation model for crawling cells on such periodically stretching substrates that is able to account for the complex shape deformations, the URLanization of the actin-network, and the coupling to the substrate .
After revision:  In particular, cells have been shown to reorient under such perturbations, aligning at specific angles with respect to the stretching direction that depends strongly on the type of cell , but also on the mechanical properties of the substrate, and the amplitude and rate of stretching. However, the underlying biochemical and mechanical mechanisms responsible for this realignment are still not completely understood. In this study, we introduce a computational model for fast crawling on cyclically stretched substrates that accounts for the sub-cellular processes responsible for the cell shape and motility, as well as the coupling to the substrate .