Before revision: A dynamic network-centric approach to study two-state folding from native structure called network dynamics (ND) is introduced. ND applies two fundamental principles of protein folding : hydrophobicity and loop-entropy, on a protein's native residue network (PRN0) to generate its native shortcut network (SCN0).
After revision: A dynamic network-centric approach to study two-state folding from native structure called network dynamics (ND) model is proposed. ND views protein folding as a partial ordering of contacts in a native-state Protein Residue Network (PRN0) to generate its native shortcut network (SCN0).