Before revision:  Our proposed method can be used as a diagnostic mechanism in contrast with or in lieu of immunohistochemical staining and may also reduce the occurrence of CUP cases .
After revision:  Our proposed method can be used as an assistive tool to assign differential diagnosis to complicated metastatic and CUP cases and could be used in conjunction with or in lieu of immunohistochemical staining and may also reduce the occurrence of CUP cases .