Before revision:  Application of this methodology to mechanosensitive channels shows that , in addition to protein separation and bilayer material properties, the sign and strength of elastic interactions , and associated cooperative gating characteristics, can depend on the protein shape and orientation .
After revision:  Application of this methodology to mechanosensitive channels shows that , in addition to protein separation and bilayer material properties, the sign and strength of elastic interactions , and associated cooperative gating characteristics, can depend on the protein shape , yielding distinct cooperative gating curves for distinct protein orientations .