Before revision:   When tested on a set of protein families from PFAM , we found the RLS algorithm to have superior performance compared to PSICOV, a state-of-the-art method for contact prediction  .
After revision:  The method also accounts for low number of observations by means of a regularization parameter that depends on the effective number of sequences in the alignment. When tested on a set of protein families from PFAM , we found the RLS algorithm to have superior performance compared to PSICOV, a state-of-the-art method for contact prediction .