Before revision: The inositol trisphosphate receptor (IPR) is a crucial Ca^{2+ channel that regulates the Ca^{2+} influx from the endoplasmic reticulum (ER) to the cytoplasm.
After revision: The inositol trisphosphate receptor (IPR) is a crucial ion channel that regulates the Ca^{2+} influx from the endoplasmic reticulum (ER) to the cytoplasm.