Before revision:  In the molecular optimization method , the best result of the optimization results of CHEMBL2325245 is MS = 1.052, PROB = 0.527, SA = 2.587, QED = 0.462. 40 molecules located in the applicability domain of RF-CDK were used for optimization, among which 34 molecules gave larger MS values .
After revision:  In the molecular optimization method , the best result of the optimization results of CHEMBL2325245 is MS = 1.052, PROB = 0.527, SA = 2.587, QED = 0.462. 40 molecules located in the applicability domain of RF-CDK model for screening drugs, we got effective compounds K1. We use the cell patch clamp method to verify K1. However, because the model evaluation method in this article is not comprehensive enough, there is still a lot of research work to be performed, such as comparison with other existing methods. The target protein has multiple active sites and requires our further research. We need more detailed models to consider this biological process and compare it with the current results, which is an error in this article. So we want to withdraw this article .