Before revision:  Examination of the determinant of the local metric tensor of the diffeomorphic mapping between each subject's ex-vivo MRI and resultant Nissl reconstruction allows an unprecedented local quantification of geometrical distortions resulting from the histological processing, showing a slight shrinkage, a median linear\pm  scale change of ~-1\% in going from the ex-vivo MRI to the tape-transfer generated histological image data\pm  .
After revision:  Examination of the determinant of the local metric tensor of the diffeomorphic mapping between each subject's ex-vivo MRI and resultant Nissl reconstruction allows an unprecedented local quantification of geometrical distortions resulting from the histological processing, showing a slight shrinkage, a median linear\pm scale change of ~-1\% in going from the ex-vivo MRI to the tape-transfer generated histological image data\pm 2.1\% per axis dimension. This is the first systematic quantification of the local metric distortions associated with whole-brain histological processing, and we expect that the results will generalize to other species .