Before revision:  symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii)  response to mechanical stress externally applied to the substrate (tensotaxis), ( iii ) changing direction of motion towards an interface with a rigid substrate (durotaxis) and ( iv ) the configuration of substrate wrinkles induced by contractile forces applied by the keratocyte.
After revision:  symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii) asymmetric bipedal oscillations and traveling waves in the lamellipodium leading edge (iii) response to mechanical stress externally applied to the substrate (tensotaxis), ( iii ) changing direction of motion towards an interface with a rigid substrate (durotaxis) and ( iv ) the configuration of substrate wrinkles induced by contractile forces applied by the keratocyte.