Before revision:  The response to DNA damage is controlled by the tumor suppressor P53 that coordinates a complex network of cellular pathways. We investigated whether the protein Tau changes the response of cells exposed to acute DNA damage .
After revision:  The response to DNA damage is controlled by the tumor suppressor P53 , the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and neurodegeneration. Here, we examined this hypothesis in the context of tauopathies, a neurodegenerative disorder group characterized by Tau protein deposition. For this, the response to an acute DNA damage .