Before revision: The move away from lock-and-key based modeling toward induced-fit based modeling has improved binding predictions but has also given rise to the challenge of modeling ligand flexibility, which requires building a database of conformational models and utilizes large amounts of data storage space.
After revision: The move away from lock-and-key based modeling toward induced-fit based modeling has improved binding predictions but has also given rise to the challenge of modeling ligand flexibility, which requires building a database of conformational models and uses large amounts of data storage space.