Before revision: Calcium  plays a central role in mediating both contractile function and hypertrophicsignalling in cardiomyocytes. While L-type Ca2+ channels (LCCs) trigger beat-to-beat re-lease of calcium through ryanodine receptors (RyRs) for cellular contraction,  inositol 1,4, 5-triphosphate receptors (IP3Rs) have been implicated in releasing Ca2+ to modify beat-to-beat calcium to concurrently signal translocation of transcription factor NFAT into the nucleus to initiate hypertrophy.
After revision: Calcium plays a central role in mediating both contractile function and hypertrophic signalling in ventricular cardiomyocytes. L-type Ca2+ channels (LCCs) trigger beat-to-beat re-lease of calcium through ryanodine receptors (RyRs) for cellular contraction, inositol 1,4, 5-triphosphate receptors (IP3Rs) have been implicated in releasing Ca2+ to modify beat-to-beat calcium to concurrently signal translocation of transcription factor NFAT into the nucleus to initiate hypertrophy.