Before revision: +Dissimilarity D between amino acidsLeuIleValGlyAlaProGlnAsnMetThrSerCysGluAspLysArgTyrPheTrpIsoleucine5Valine97Glycine242519Alanine1517129Proline2324201716Glutamine222425322633Asparagine20232326253110Methionine2022233425311321Threonine232117202025241925Serine23252019162421152212Cysteine2426212113252219171913Glutamic acid303131373443141926342933Aspartic acid2528283330402214312925287Lysine2324263126312127243431322634Arginine333436433743233128383736313914Tyrosine30343636343729283232293434343436Phenylalanine1922262926272424242825293535283413Tryptophan303437393637313231383537434534362113Histidine25283134293627243034283127352731231825 Epstein's coefficient of difference Epstein's coefficient of difference is based on the differences in polarity and size between replaced pairs of amino acids.
After revision: +Dissimilarity D between amino acidsLeuIleValGlyAlaProGlnAsnMetThrSerCysGluAspLysArgTyrPheTrpIle5Val97Gly242519Ala1517129Pro2324201716Gln222425322633Asn20232326253110Met2022233425311321Thr232117202025241925Ser23252019162421152212Cys2426212113252219171913Glu303131373443141926342933Asp2528283330402214312925287Lys2324263126312127243431322634Arg333436433743233128383736313914Tyr30343636343729283232293434343436Phe1922262926272424242825293535283413Trp303437393637313231383537434534362113His25283134293627243034283127352731231825 Epstein's coefficient of difference Epstein's coefficient of difference is based on the differences in polarity and size between replaced pairs of amino acids.