Before revision:  We predict the assembly crucial interactions by measuring the entropy change of the capsid assembly system before and after the removal of each interaction. The entropy-change is measured by analysis of the viral capsid configuration space on two levels. On the interface level the entropy of the small interface assembly system is approximated by the sampling of the configurational space using the recently reported geometric method called  EASAL (efficient atlasing and sampling of assembly landscapes) .
After revision:  We predict the assembly crucial interactions by measuring the entropy change of the capsid assembly landscape when an interaction is removed. At the interface-scale, the partition function computation uses EASAL (efficient atlasing and sampling of assembly landscapes) .