Before revision: The method of moments has been proposed as a potential means to reduce the dimensionality of the chemical master equation (CME) appearing in stochastic chemical kinetics . However, attempts to apply the method of moments to the CME usually result in the so-called closure problem.
After revision: The method of moments has been proposed as a potential means to reduce the dimensionality of the chemical master equation (CME) appearing in stochastic chemical kinetics often leads to the so-called closure problem.