Before revision:  Here we report computational evidence that Structural Maintenance of Chromosomes (SMC) proteins -- such as cohesins and condensins -- can cooperate with TopoII to establish a synergistic mechanism to resolve topological entanglements : SMC-driven loop extrusion (or diffusion) induces the spatial localisation of entanglements in turn increasing the topological pressure within knotted or linked regions. As a consequence, knots , links and ensuing entanglements may be readily simplified by Topoisomerase enzymes even in crowded and confined conditions.
After revision:  Here we report computational evidence that Structural Maintenance of Chromosomes (SMC) proteins -- such as cohesins and condensins -- can cooperate with TopoII to establish a synergistic mechanism to resolve topological entanglements : SMC-driven loop extrusion (or diffusion) induces the spatial localisation of essential crossings in turn catalysing the simplification of knots and links by TopoII enzymes even in crowded and confined conditions.