Before revision:  When used as restraints in molecular dynamics simulations, the inferred contacts improve RNA 3D structure prediction to a coordinate error as low as 6 to 10 Angstrom rmsd with potential for use with other constraints. These contacts include functionally important interactions, such as those that distinguish the active and inactive conformations of four riboswitches. In blind prediction mode, we present evolutionary couplings for 180 RNAs of unknown structure (available at URL  We anticipate that this approach will shed light on the structure and function of as yet less known RNA genes.
After revision:  These contacts allow all-atom blinded structure prediction with an accuracy of 6-10 rmsd. We present evolutionary couplings for 180 RNAs of unknown structure (available at URL We anticipate that this approach will shed light on the structure and function of as yet less known RNA genes.