Before revision: Evolutionary algorithms are parallel computing algorithms and simulated annealing algorithm is a sequential computing algorithm. This paper inserts simulated annealing into evolutionary computations and successful developed a hybrid Self-Adaptive Evolutionary Strategy \mu+\lambda method and a hybrid Self-Adaptive Classical Evolutionary Programming method. Numerical results on more than 40 benchmark test problems of global optimization show that the hybrid methods presented in this paper are very effective. Lennard-Jones potential energy minimization is another benchmark for testing new global optimization algorithms. It is studied through the amyloid fibril constructions by this paper. To date , there is little molecular structural data available  on the AGAAAAGA palindrome in the hydrophobic region ( 113-120 ) of prion proteins .
After revision: X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy are two powerful tools to determine the protein 3D structure. However, not all proteins can be successfully crystallized, particularly for membrane proteins. Although NMR spectroscopy is indeed very powerful in determining the 3D structures of membrane proteins, same as X-ray crystallography, it is still very time-consuming and expensive. Under many circumstances, due to the noncrystalline and insoluble nature of some proteins, X-ray and NMR cannot be used at all. Computational approaches, however, allow us to obtain a description of the protein 3D structure at a submicroscopic level. To the best of the author's knowledge , there is little molecular structural data available on the AGAAAAGA palindrome in the hydrophobic region ( 113-120 ) of prion proteins .