Before revision:  For these calculations{\bf   we use a model that captures both the mechano-chemistry of each individual ribosome as well as their steric interactions in ribosome traffic on the same mRNA track. By comparing our results for a specific gene of the Escherichia coli bacteria with those for the corresponding homogeneous mRNA template, we demonstrate the effects of the sequence inhomogeneities of real genes on the fluctuations and noise .
After revision:  For these calculations{\bf we use a model that captures both the mechano-chemistry of each individual ribosome as well as their steric interactions  Escherichia coli bacteria with those for the corresponding homogeneous mRNA template, we demonstrate the effects of the sequence inhomogeneities of real genes on the fluctuations and noise .