Before revision:  A perspective based on side-chain networks can provide valuable insights into the differences in global connectivity features between various dynamical states of a protein. This is especially important to capture subtle conformational changes.
After revision:  A perspective based on side-chain networks can provide valuable insights into the differences in global connectivity features between various dynamical states of proteins. Our objective is to review network-based analyses to elucidate such variations, especially in the context of subtle conformational changes.