Before revision:  The trial-shuffle method, for spike train data that is split into multiple trials, determines significant transfer entropy values independently for each individual pair of neurons , rather than globally comparing all neuron transfer entropy values .
After revision:  The trial-shuffle method, for spike train data that is split into multiple trials, determines significant transfer entropy values independently for each individual pair of neurons by comparing to a created baseline distribution using a rigorous statistical test. This is in contrast to either globally comparing all neuron transfer entropy values .