Before revision:  In this study, we characterize the calcium dynamics of cocultured monolayers of fibroblast cells and breast cancer cells in response to external ATP stimuli. We find that gap junctional communication is suppressed by the presence of cancer cells, similar in effect to reducing cell density. The ATP-induced calcium dynamics of nearest neighbor cells are correlated, and the cross-correlation functions depend on both ATP concentration and the architecture of the multicellular network.
After revision:  In this study, we characterize the calcium dynamics of cocultured monolayers of fibroblast cells that communicate via gap junctions.