Before revision:  We illustrate our approach on the central carbon metabolism of Escherichia coli , and on a larger metabolic model of human hepatocytes , and study the proposed graphs under various environmental conditions and genetic perturbations . The results reveal drastic changes in the topological and community structure of the metabolic graphs , which capture the re-routing of metabolic fluxes under each growth and genetic condition .
After revision:  We illustrate our approach on the central carbon metabolism of Escherichia coli , and on a larger metabolic model of human hepatocytes , and study the proposed graphs under various environmental conditions and genetic perturbations exhibit systemic changes in their topological and community structure of the metabolic graphs , which capture the re-routing of metabolic fluxes under each growth and genetic condition .