Before revision:  Interestingly, in the pluripotent state, miRNAs do not directly regulate the pluripotent core activities but mediate extrinsic signal pathways associated with the pluripotency;
After revision:  Interestingly, in the pluripotent state, miRNAs do not directly regulate the pluripotent core factors but only mediate extrinsic signal pathways associated with the pluripotency;