Before revision:  Recently, algorithms based on Direct Coupling Analysis (DCA) pairwise maximum-entropy models have allowed to identify interaction partners among the paralogs of ubiquitous prokaryotic proteins families, starting from sequence data alone. Since DCA allows to infer the three-dimensional structure of protein complexes, its success in predicting protein-protein interactions could be mainly based on contacting residues coevolving to remain physicochemically complementary.
After revision:  Recently, algorithms based on Direct Coupling Analysis (DCA) pairwise maximum-entropy models have allowed to identify interaction partners among the paralogs of ubiquitous prokaryotic proteins families, starting from sequence data . This success of DCA at predicting protein-protein interactions could be mainly based on contacting residues coevolving to remain physicochemically complementary.