Before revision: Epigenetic modifications of histones crucially affect the eukaryotic gene activity . We theoretically analyze the dynamical effects of histone modifications on gene switching by using the Doi-Peliti operator formalism of chemical reaction kinetics .
After revision: Epigenetic modifications of histones crucially affect the eukaryotic gene activity , while the epigenetic histone state is largely determined by the binding of specific factors such as the transcription factors (TFs) to DNA. Here, the way how the TFs and the histone state are dynamically correlated is not obvious when the TF synthesis is regulated by the histone state. This type of feedback regulatory relations are ubiquitous in gene networks to determine cell fate in differentiation and other cell transformations. To gain insights into such dynamical feedback regulations, we theoretically analyze a model of epigenetic gene switching by using the Doi-Peliti operator formalism of chemical reaction kinetics .