Before revision: This is mediated via activation of the protein receptor PGC-1α, which alters the isoenzyme composition of the LDH complex and decreases the activity of the lactate generating enzyme LDHA , while increasing the activity of the lactate metabolizing enzyme LDHB .
After revision: This is mediated via activation of the protein receptor PGC-1α, which alters the isoenzyme composition of the lactate dehydrogenase (LDH) complex and decreases the activity of lactate dehydrogenase A (LDHA) , while increasing the activity of lactate dehydrogenase B (LDHB) .