Before revision: In this article , we present a polymer model of the chromosome that can be parameterized to quantitatively reproduce contact probabilities measured in high-throughput chromosome conformation capture  (Hi-C) or genome architecture mapping  (GAM) experiments. Specifically, our Gaussian effective model (GEM) introduces harmonic potentials to represent interactions detected during such experiments. As a central property, we derive an exact relation between the couplings of these potentials and the resulting contact probabilities .
After revision: In this article , we present a polymer model of the chromosome that can be parameterized to quantitatively reproduce contact probabilities measured in high-throughput chromosome conformation capture (Hi-C) or genome architecture mapping (GAM) .