Before revision:  GeneSurrounder integrates transcriptomic data and pathway network information in a novel two--step procedure to detect genes that (i) appear to influence the expression of other genes local to it in the network and (ii) are part of a subnetwork of differentially expressed genes.
After revision:  GeneSurrounder integrates transcriptomic data and pathway network information in a novel two-step procedure to detect genes that (i) appear to influence the expression of other genes local to it in the network and (ii) are part of a subnetwork of differentially expressed genes.