Before revision:  In this study, we show that the RNAP-II based reinitiation process in gene expression can increase or decrease the mean and Fano factor both at the mRNA levels and therefore, can have important contributions on cellular functions .
After revision:  In this study, we show that the RNAP-II based reinitiation process in gene expression can increase or decrease the mean and Fano factor both at the mRNA levels in the constitutive network whereas in other networks it can simultaneously increase or decrease both quantities or it can have mixed-effect at mRNA levels. We propose that a constitutive network with reinitiation behaves like a product independent negative feedback circuit whereas other networks behave as either product independent positive or negative or mixed feedback circuit .