Before revision:  The idea is based on modeling the effects of the pH value on the main driving interactions using reference data from atomistic simulations and experimental databases and transferring its main physical features to the coarse-grained resolution according the principle of  consistency across the scales . After refining the coarse-grained model appropriately this was achieved by finding a unique set of parameters for the coarse-grained model that,
After revision:  The idea is based on modeling the effects of the pH value on the main driving interactions . We use reference data from atomistic simulations and experimental databases and transferring its main physical features to the coarse-grained resolution according the principle of consistency across the scales . After refining the coarse-grained model appropriately this was achieved by finding a unique set of parameters for the coarse-grained model that,