Before revision:  Finally, based on observing our MD trajectories of the PFA1 antibody bound to ABeta_2-7 and pE3ABeta_3-8 ,  we introduced rational mutations into PFA1 in an effort to improve the calculated binding affinity of PFA1 towards the pE3-ABeta_3-8 form of ABeta.
After revision:  Finally, based on observing our MD trajectories of the PFA1 antibody bound to ABeta_2-7 and pE3ABeta_3-8 , we introduced rational mutations into PFA1 to improve its calculated binding affinity of PFA1 towards the pE3-ABeta_3-8 form of ABeta.