Before revision:  By integrating genetics, biophysics, deep learning, and algebraic topology, we deduce that some of the mutations such as M153I, S254F, and S255F may weaken the binding of S protein and antibodies , and potentially disrupt the efficacy and reliability of antibody therapies and vaccines in the development.
After revision:  By integrating genetics, biophysics, deep learning, and algebraic topology, we reveal that most of 462 mutations on the receptor-binding domain (RBD) will weaken the binding of S protein and antibodies , and potentially disrupt the efficacy and reliability of antibody therapies and vaccines in the development.