Before revision:  Secondary bone cancer (SBC) is a complex disease  characterized by intricate molecular mechanisms. Metastasis of primary breast cancer and prostate cancer cells is the main cause of SBC. Towards our goal of identifying SBC-specific targets , we use a strategy based on protein interactome analysis and gene ontologies. First, we compiled a well-curated dataset of 83 SBC genes(SBCGs). Further, we constructed protein interactome comprising of proteins known to be involved in generic cancer mechanisms and also for those implicated in SBC mechanisms. We hypothesize that these protein interaction networks embody mechanisms and processes that are relevant in generic cancers and those specific to SBC, respectively.
After revision:  Secondary bone cancer (SBC) is a complex disease characterized by intricate interplay of molecular interactions. Identification of targets for multifactorial diseases such as SBC, the most frequent complication of breast and those specific to SBC, respectively.