Before revision: However, one sulfonamide ester of estradiol related to EC508 known as EC518 showed similar properties with very low or absent binding to CAII and hence probably lacking erythrocyte binding, which raises questions as to whether or how this is possible as well as about the necessity of CAII binding for such properties.
After revision: However, one sulfonamide ester of estradiol related to EC508 known as EC518 showed similar properties with very low or absent binding to CAII and hence probably lacking erythrocyte binding, which raises questions about the necessity of CAII binding for such properties.