Before revision:  By coupling our model to a well-established framework for large-scale 3D URLanisation we discover that the non-random integration of HIV in human chromatin may be explained as due to large-scale accessibilityof interphase chromosomes. Finally we propose and solve a reaction-diffusion model that recapitulates the distribution of HIV hot-spots within the nucleus of human T-cells.
After revision:  By coupling our model to a well-established framework for large-scale 3D URLanisation we discover that at these larger scales integration sites are predominantly determined by chromatin accessibility. Finally, we propose and solve a reaction-diffusion model that recapitulates the distribution of HIV hot-spots within the nucleus of human T-cells.