Before revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferase, core enzymes for DNA methylation, and decreasing methylation in turn activates the top miRNAs.
After revision:  Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation, and decreasing methylation in turn activates the top miRNAs.