Before revision:  Our imaging evidence of structural alterations in IGEs may be applied as non-invasive diagnostic biomarker. We suggest that impaired connectivity from cortical regions to the thalamic reticular nucleus offers a therapeutic target for selectively modifying the brain circuit to reverse the mechanisms leading to epileptogenesis.
After revision:  Our imaging evidence of structural alterations suggest the loss of cortico-cortical and enhancement of cortico-thalamic fibre integrity in IGE. We further suggest that impaired connectivity from cortical regions to the thalamic reticular nucleus offers a therapeutic target for selectively modifying the brain circuit to reverse the mechanisms leading to epileptogenesis.