Before revision:  We show that both eukaryotic clpB amyloid disaggregases , HSP104 and its nuclear-encoded mitochondrial endo-ortholog HSP78, were lost in the stem-metazoan lineage along with only a small number of other relevant genes.
After revision:  We show that both eukaryotic clpB orthologs , HSP104 and its nuclear-encoded mitochondrial endo-ortholog HSP78, were lost in the stem-metazoan lineage along with only a small number of other relevant genes.