Before revision:  Interestingly, in the pluripotent state, miRNAs do not directly regulate the pluripotent core activities but mediate extrinsic signal pathways associated with the pluripotency; however in the differential state, miRNAs directly repress the pluripotency.
After revision:  Interestingly, in the pluripotent state, miRNAs do not directly regulate the pluripotent core activities but mediate extrinsic signal pathways associated with pluripotency. During differentiation miRNAs mechanistically inhibit metabolism and directly repress the pluripotency.