Before revision:  Through this approach, we observe SentRNA can learn and apply human-like design strategies to solve several complex targets previously unsolvable by any computational approach . We thus demonstrate that incorporating a prior of human design strategies into a computational agent can significantly boost its performance , and suggests a new paradigm for machine-based RNA design.
After revision:  Through this approach, we observe SentRNA can learn and apply human-like design strategies to solve several complex targets previously unsolvable by any machine-based approach and achieve state-of-the-art performance on two separate challenging test sets. Our results demonstrate that incorporating a prior of human design strategies into a computational agent can significantly boost its performance , and suggests a new paradigm for machine-based RNA design.