Before revision:  A Boltzmann machine for the accurate estimation of the field and coupling interactions, which is required for other studies in protein evolution and folding, is studied about learning methods , regularization models and a tuning method of regularization parameters in order to infer the interactions with reasonable characteristics . Using L_2 regularization for fields, group L_1 for couplings is shown to be very effective for parse couplings in comparison with L_2 and with L_1.
After revision:  A Boltzmann machine for the accurate estimation of the field and coupling interactions, which is required for other studies in protein evolution and how to tune regularization parameters to correctly infer interactions in Boltzmann machine learning . Using L_2 regularization for fields, group L_1 for couplings is shown to be very effective for parse couplings in comparison with L_2 and with L_1.