Before revision:  This approach is applied to solve several drug design problems,  generation of compounds containing a given scaffold, generation of compounds with specific drug-likeness and synthetic accessibility requirements, as well as generating dual inhibitors against JNK3 and GSK3b . Results show high enrichment rates for outputs satisfying the given requirements.
After revision:  This approach is applied to solve several drug design problems, generation of compounds containing a given scaffold, generation of compounds with specific drug-likeness and synthetic accessibility requirements, as well as generating dual inhibitors against JNK3 and GSK3\beta . Results show high enrichment rates for outputs satisfying the given requirements.