Before revision:  If the enzyme suddenly returns to its initial state after the binding stage, the substrate ends in a quantum superposition state. Environmental effects can then naturally drive the reaction in the forward direction from the substrate to the product without needing the additional catalytic stage that is usually assumed to follow the binding stage .
After revision:  If the enzyme suddenly returns to its initial state after the binding stage, the substrate ends in a new transition state corresponding to a quantum superposition. Open quantum system dynamics can then naturally drive the reaction in the forward direction from the substrate to the product without needing the additional catalytic stage that is usually assumed to follow the binding stage .