Before revision: Many studies have shown that the icosahedral symmetry adopted by most spherical viruses is the result of free energy minimization of a generic interaction between virus proteins.
After revision: Highly symmetric nano-shells are found in many biological systems, such as clathrin cages and viral shells. Several studies have shown that the icosahedral symmetry adopted by most spherical viruses is the result of free energy minimization of a generic interaction between virus proteins.