Before revision:  In E. coli, the analysis of how pathways are entangled through essential plasticity and redundancy supports the view that synthetic lethality affects preferentially a single function or pathway , although with a major exception which unveils Cell Envelope Biosysthesis as an essential backup to Membrane Lipid Metabolism.
After revision:  In E. coli, the analysis of how pathways are entangled through essential plasticity and redundancy supports the view that synthetic lethality affects preferentially a single function or pathway . In contrast, essential plasticity, the dominant class, tends to be inter-pathway but concentrated and unveils Cell Envelope Biosysthesis as an essential backup to Membrane Lipid Metabolism.