Before revision:  We propose that a general mechanism for adaptive dynamic range enlargement comes about from the activity-dependent modulation of protein responsiveness by multiple biochemical modification  .
After revision:  In particular a precise adaptive response, where system activity is maintained at a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in system output. A general mechanism for adaptive dynamic range enlargement comes about from the activity-dependent modulation of protein responsiveness by multiple biochemical modification .