Before revision:  We introduce the notion of "Catalytic force" Cf , as a back-action effect of the molecular target of catalysis on the catalytic microenvironment , adjusting the microenvironment towards a state that facilitates the catalytic act.
After revision:  We introduce the notion of "Catalytic force" Cf , as a back-action effect of the molecular target of catalysis on the catalytic microenvironment that adjusts the microenvironment towards a state that facilitates the catalytic act.