Before revision:  Some pathogens become so deadly that they put the whole technological advancement of humans under question-such as the case of SARS-CoV-2, however, this is not the only time.
After revision:  Some of these pathogens, such as SARS-CoV-2, become so deadly that they put the whole technological advancement of humans under question-such as the case of SARS-CoV-2, however, this is not the only time.