Before revision:  We have implemented the algorithm in MATLAB, building upon COBRA toolbox v2.0 . Fast-SL also compares favourably with SL Finder, an algorithm for identifying synthetic lethal sets, by Suthers et al (2009), which involves the solution of  bi-level Mixed Integer Linear Programming problem  .
After revision:  Fast-SL offers a substantial speed-up through a massive reduction in the search space for synthetic lethals; in the case of E. coli, Fast-SL reduces the search space for synthetic lethal triplets by over 4000-fold . Fast-SL also compares favourably with SL Finder, an algorithm for identifying synthetic lethal sets, by Suthers et al (2009), which involves the solution of bi-level Mixed Integer Linear Programming problem .