Before revision: Many pairwise additive force fields parameterized to reproduce folded protein structures are in active use for intrinsically disordered proteins (IDPs) and regions (IDRs), most of which are found to disagree with solution experiments for the disordered states.
After revision: Many pairwise additive force fields are in active use for intrinsically disordered proteins (IDPs) and regions (IDRs), most of which are found to disagree with solution experiments for the disordered states.