Before revision: Cholesterol and ergosterol are two dominant sterols in the membranes of eukaryotic and yeast cells, respectively. Although their chemical structure is very similar, their impact on the structure and dynamics of membranes differs. In this work, we have explored the effect of these two sterols on binary mixtures with  1, 2-dipalnitoyl-sn-glycerol-3-phosphocholine (DPPC) lipid bilayer at various sterol concentration and temperatures , employing molecular dynamics simulations.
After revision: Sterols have been ascribed a major role in URLanization of biological membranes, in particular for the formation of liquid ordered domains in complex lipid mixtures. Interestingly, evolution has resulted in a preference for chemically similar but distinct sterol types - with cholesterol the major sterol of mammalian cells and ergosterol dominating in membranes of fungal cells. However, the molecular basis and functional consequences of the choice in sterols are not well understood. Here, we employed molecular dynamics simulations to compare the effects of cholesterol and ergosterol on binary mixtures with 1, 2-dipalnitoyl-sn-glycerol-3-phosphocholine (DPPC) lipid bilayer at various sterol concentration and temperatures , employing molecular dynamics simulations.