Before revision:  To address this issue, we built a mathematical model of RAS based on data about protein and peptide concentrations in normotensive and hypertensive individuals. We first tested our model on clinical data on the action of antihypertensive RAS-blocking drugs in control individuals.
After revision:  To address this issue, we built a mathematical model of RAS based on data about protein and peptide concentrations ; the model was tested on clinical data on the action of antihypertensive RAS-blocking drugs in control individuals.