Before revision: One difference between hyperendemic and holoendemic diseases is that hyperendemic diseases show a seasonally intense transmission in all age groups with a period of low or no transmission, whereas in holoendemic diseases, there is perennial (year-round) intense transmission especially among children with higher immunity among adults.
After revision: One of the differences between hyperendemic and holoendemic diseases is that hyperendemic diseases show a seasonally intense transmission in all age groups with a period of low or no transmission, whereas in holoendemic diseases, there is perennial (year-round) high level of transmission predominantly among young population with higher immunity among adults.