Before revision:  Although the enzymes involved in multiple glycan substrates indicate cross-talk between modules, the impact of the cross-talk on the module-specific enhancement of glycan synthesis could be confined within a moderate range by transcriptional-level control. Our findings give the experimentally-testable predictions for glycosylation processes, and can be potentially applied to the engineering of therapeutic glycoproteins .
After revision:  Although the enzymes involved in multiple glycan substrates indicate cross-talk between modules, the impact of the cross-talk on the module-specific enhancement of glycan synthesis could be confined within a moderate range by transcription-level control. The findings of the present study provide experimentally-testable predictions for glycosylation processes, and can be potentially applied to the engineering of therapeutic glycoproteins .