Before revision:  To study those effects , we introduce a three-dimensional reaction-diffusion model of a cell. As some key molecules in cell polarization, such as the small GTPases, can exist both membrane bound and soluble in the cytosol, we first look at the role of cell geometry on the membrane binding/unbinding dynamics of such molecules.
After revision:  To study those effects , we introduce a three-dimensional reaction-diffusion model of interacting molecules in a single cell, and find that cell geometry has an important role affecting the capability of a cell polarization, such as the small GTPases, can exist both membrane bound and soluble in the cytosol, we first look at the role of cell geometry on the membrane binding/unbinding dynamics of such molecules.