Before revision:  Further, our contact-assisted models also have much better quality (especially for membrane proteins ) than template-based models .
After revision:  Further, our contact-assisted models also have much better quality than template-based models. Using our predicted contacts as restraints, we can (ab initio) fold 208 of the 398 membrane proteins with TMscore>0.5. By contrast, when the training proteins of our method are used as templates, homology modeling can only do so for 10 of them. One interesting finding is that even if we do not train our prediction models with any membrane proteins, our method still works well on membrane protein prediction .