Before revision:  The hardness of the problem comes from the superposition between the driving forces of intra- and inter-molecule interactions and it is mirrored by the evidences of shift from folding to aggregation phenotypes by single-point mutations \mbox{%DIFAUXCMD doi:10.1021/ja1116233  state-of-the-art classification methods coming from the field of structural pattern recognition, with the aim to compare different representations of the same proteins of the Niwa et al. data base , going from pure sequence to chemico-physical labeled (contact) graphs  .
After revision:  The hardness of the problem comes from the superposition between the driving forces of intra- and inter-molecule interactions and it is mirrored by the evidences of shift from folding to aggregation phenotypes by single-point mutations 10 state-of-the-art classification methods coming from the field of structural pattern recognition, with the aim to compare different representations of the same proteins of the Niwa et al. data base , going from pure sequence to chemico-physical labeled (contact) graphs .