Before revision:  The very essential of the thermodynamic principle, a Gibbs free energy formula G(   ) for every possible conformation   of the protein , has never been theoretically formulated from the fundamental physical laws. We will apply quantum statistics to derive such a formula.
After revision:  The very essential of the thermodynamic principle, a Gibbs free energy formula G(  ) for every possible conformation  of the protein . We apply quantum statistics to derive such a formula.