Before revision:  Each controller acts on many targets, and target nodes are controlled by many controllers in a strongly overlapping many-to-many network structure. We present a quantitative analysis of the network properties of three key biological systems for which sufficiently comprehensive datasets are now available: transcription factors, microRNAs  and protein kinases .
After revision:  Each controller acts on many targets, and target nodes are controlled by many controllers in a strongly overlapping many-to-many " combinatorial control systems are poorly understood. Here we analyze distinct cellular networks ( transcription factors, microRNAs and protein kinases .