Before revision:  We have recently shown that spark termination emerges as collective behavior (synchronized closings) of Ca release channels (RyRs) that is identical to synchronization of spin orientation in ferromagnets described by a phase transition in Ising model . Objective: We employed the Ising approach to investigate and classify mechanisms of spark termination failure and Ca leak.
After revision:  Here we employed both numerical and analytical modeling to get mechanistic insights into the emergent Ca leak phenomenon. Our numerical simulations using a detailed realistic model of Ca release channels (RyRs) that is identical to synchronization of spin orientation in ferromagnets described by a phase transition in Ising model . Objective: We employed the Ising approach to investigate and classify mechanisms of spark termination failure and Ca leak.