Before revision:  As experiments are becoming increasingly precise and the deviations from the two-state model start to be observable, we ask about the experimental signatures of complex multi-state promoters, as well as their functional consequences .
After revision:  As experiments are becoming increasingly precise and the deviations from the two-state model start to be observable, we ask about the experimental signatures of complex multi-state promoters, as well as the functional consequences of this additional complexity .