Before revision:  we are able to reproduce the rates from atomistic molecular dynamics simulation and experiments within a factor of 1.5-4 for unbinding times up to the range of milliseconds and of 1.2-10 in the range of seconds . Analysis of the friction profiles reveals that binding and unbinding dynamics are mediated by changes of the surrounding hydration shells in all investigated systems.
After revision:  we are able to reproduce the rates from atomistic molecular dynamics simulation and experiments within a factor of 2-20, and dissociation constants within a factor of 1-4 . Analysis of the friction profiles reveals that binding and unbinding dynamics are mediated by changes of the surrounding hydration shells in all investigated systems.