Before revision:  In fact, dissipation can be reduced by the effect of noise, as occurs in a simplified core model of metabolism that we employ to illustrate our findings  .
After revision:  In fact, dissipation can be reduced by the effect of noise, as occurs in a simplified core model of metabolism that we employ to illustrate our findings . This phenomenon highlights that there is a close interplay between deficiency and the activation of new dissipative pathways at low molecule numbers .