Before revision:  Random Acceleration MD (RAMD) is a simple method to enhance ligand egress from a macromolecular binding site that does not require the user to choose a ligand egress reaction coordinate. It thus enables the unbiased exploration of ligand egress routes  .
After revision:  Random Acceleration MD (RAMD) is a simple method to enhance ligand egress from a macromolecular binding site , which enables the exploration of ligand egress routes .