Before revision:  We next prove that only non-equilibrium systems can lift this trade-off : They can integrate the receptor state over time while suppressing the intrinsic noise by using energy to store the receptor state into stable modification states of the readout molecules.
After revision:  We next prove that only non-equilibrium systems can lift this trade-off by storing the receptor state over time while suppressing the intrinsic noise by using energy to store the receptor state into stable modification states of the readout molecules.