Before revision:  While L-type Ca2+ channels (LCCs) trigger beat-to-beat re-lease of calcium through ryanodine receptors (RyRs) for cellular contraction,  inositol 1,4, 5-triphosphate receptors (IP3Rs) have been implicated in releasing Ca2+ to modify beat-to-beat calcium to concurrently signal translocation of transcription factor NFAT into the nucleus to initiate hypertrophy.
After revision:  While L-type Ca2+ channels (LCCs) trigger beat-to-beat re-lease of calcium through ryanodine receptors (RyRs) for cellular contraction, inositol 1,4, 5-triphosphate receptors (IP3Rs) , engaging hypertrophic signalling pathways. Modulation of the amplitude, duration, and duty cycle of the cytosolic Ca2+ to modify beat-to-beat calcium to concurrently signal translocation of transcription factor NFAT into the nucleus to initiate hypertrophy.