Before revision:  PIMKL exploits prior knowledge in the form of molecular interaction networks and annotated gene sets, by optimizing a mixture of pathway-induced kernels using a Multiple Kernel Learning algorithm (MKL)  , an approach that has demonstrated excellent performance in different machine learning applications.
After revision:  PIMKL exploits prior knowledge in the form of molecular interaction networks and annotated gene sets, by optimizing a mixture of pathway-induced kernels using a Multiple Kernel Learning algorithm (MKL) algorithm , an approach that has demonstrated excellent performance in different machine learning applications.