Before revision:  In this work,  molecular dynamics simulations have been employed in order to study structure and dynamics of the activation loop of the Aurora-A kinase . The main conformational states were determined using a clustering analysis routine within the AMBER software and the predominant modes of motion of the activation were determined performing a principal component analysis that revealed different degree of flexibility within the  activation loop .
After revision:  In this work, molecular dynamics simulations have been employed in order to study structure and dynamics of the activation loop of the Aurora-A kinase and of the activation loop .