Before revision: sgRNAs are recovered, analysed, and associated genes identified.|alt=| 692x692px History Early studies in Caenorhabditis elegans and Drosophila melanogaster saw large-scale, systematic loss of function (LOF) screens performed through saturation mutagenesis, demonstrating the potential of this approach to characterise genetic pathways and identify genes with unique and essential functions.
After revision: sgRNAs are recovered, analysed, and associated genes identified.|alt=| 300x300px History Early studies in Caenorhabditis elegans and Drosophila melanogaster saw large-scale, systematic loss of function (LOF) screens performed through saturation mutagenesis, demonstrating the potential of this approach to characterise genetic pathways and identify genes with unique and essential functions.