Before revision:  Our result is completely independent of the receptor architecture and dependent on signal properties alone, and therefore holds as a general principle for molecular information processing . A Maxwell's Demon performing non-perturbing measurements must produce entropy at a rate greater than or equal to our bound, irrespective of how it is designed .
After revision:  Our result is completely independent of the receptor architecture and dependent on signal properties alone, and therefore holds as a general principle for molecular information processing .