Before revision:  Generally, miRNAs primarily repress developmental processes, but surprisingly the top up-regulated miRNAs do not directly target the pluripotent core factors as thought ; they only target the signal pathways associated with pluripotency. This suggests that the most important miRNAs in stem cells may only indirectly regulate the pluripotency. Interestingly, miRNAs predominately target and repress DNA methyltransferases, the core enzymes for DNA methylation , and decreasing methylation in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors for pluripotency.
After revision:  Generally, miRNAs primarily repress developmental processes, but surprisingly the top up-regulated miRNAs do not directly target the pluripotent core factors as thought , but they only directly target the pluripotent signal pathways and directly repress developmental processes. Furthermore, at pluripotent state miRNAs predominately repress DNA methyltransferases, the core enzymes for DNA methylation , and decreasing methylation in turn activates the top miRNAs . This system-wide circuit between up-regulated miRNAs and the repressed DNA methylation system eventually activates the pluripotent core factors for pluripotency.