Before revision:  Here, we investigate the dynamics of switching between metastable states of a feedback based on/off switch , by employing the WKB theory to treat the underlying master equations.
After revision:  Here, we investigate the dynamics of switching between metastable states of a feedback based on/off switch . Unlike protein-only models, we explicitly account for stochastic fluctuations of mRNA, which have a dramatic impact on switch dynamics. Employing the WKB theory to treat the underlying master equations.