Before revision: Other factors Exercise fatigue has also been suggested to be affected by: brain hyperthermia glycogen depletion in brain cells reactive oxygen species impairing skeletal muscle function reduced level of glutamate secondary to uptake of ammonia in the brain Fatigue in diaphragm and abdominal respiratory muscles limiting breathing Impaired oxygen supply to muscles Ammonia effects upon the brain Serotonin pathways in the brain Cardiac biomarkers Prolonged exercise such as marathons can increase cardiac biomarkers such as troponin, B-type natriuretic peptide (BNP), and ischemia-modified (aka MI) albumin.
After revision: depletion of muscle and liver glycogen (see "hitting the wall")Other factors Exercise fatigue has also been suggested to be affected by: brain hyperthermia glycogen depletion in brain cells reactive oxygen species impairing skeletal muscle function reduced level of glutamate secondary to uptake of ammonia in the brain Fatigue in diaphragm and abdominal respiratory muscles limiting breathing Impaired oxygen supply to muscles Ammonia effects upon the brain Serotonin pathways in the brain Cardiac biomarkers Prolonged exercise such as marathons can increase cardiac biomarkers such as troponin, B-type natriuretic peptide (BNP), and ischemia-modified (aka MI) albumin.