Peripheral blood mononuclear cells (PBMCs) were isolated from a WOREE patient and from his healthy parents and were reprogrammed into iPSCs, and subsequently were differentiated into COs. Representative traces of spontaneous spikes recorded from neurons of WSM P (blue), WSM S (red) WSM S W-AAV (purple) week 7 COs. Each recording is 12 seconds long and the zoom-in is of 0.5 seconds (red box on the right). 