Model of the regulation of ferritin fate by NCOA4 in cellular iron homeostasis. Under iron depletion, ferritin is degraded by the NCOA4 dependent macroautophagy pathway. In the early phase of iron treatment, NCOA4 forms condensates that sequester ferritin for ferritin accumulation. During prolonged iron treatment, NCOA4 condensates bind ferritin, forming a complex that is trafficked to the lysosome in a TAX1BP1-dependent manner to avoid iron deficiency. 