(C‑D) Activation of NK cells in the draining lymph node requires collective DC activation. (C) Representative histograms showing granzyme B and CD69 expression by NK 1.1+ Ly6Clow cells in dLN of 90:10 (dark blue) and 5:95 (grey) WT:Irf3‑/‑Irf7‑/‑ chimeric mice injected with poly(I:C) or with PBS (black line). (D) Quantification of granzyme B intracellular content (left) and CD69 expression (right) in NK1.1+ Ly6Clow cells of chimeric mice injected with poly(I:C), expressed as a fold change in gMFI over PBS‑injected controls. Data are pooled from 2 independent experiments. 