ILCs are characterized by tumor-cell intrinsic ECM modulating activities, including expression of different collagens, elastin and various secreted proteases like LOXL1 and ADAMTS family members. Cell invasion and metastases is facilitated by the biochemical changes in the ECM and LOXL1 inhibition leads to reduced ER signaling, resulting in decreased survival and diminished proliferation of ILC cells and inhibition of tumor progression. 