(A) Super-pedigree mapping of two mutations in Wdr37 that are linked to peripheral B cell deficiency. Insert shows peripheral B cell deficiency in radical (N=12 REF, 18 HET, 4 VAR) and profound (N=14 REF, 15 HET, 6 VAR) pedigrees. Horizontal bars indicate mean values. Ordinary one-way ANOVA with Tukey's multiple comparisons test, ns = not significant, ***P < 0.001. 