E, F Quantification of the time spent (E) and the time active (F) in the light side of the light dark box. Data are the mean of 12 male (WT), 1 male (11B), 9 female (WT) and 12 female (11B) adult littermate mice. Error bars indicate SD, two-tailed unpaired Student's t-test, * P < 0.05. P = 0. 0417 (E, male); P = 0. 0401 (F, male). Data information: The lack of statistical significance for female WT vs. 11B mice in the light dark box test presumably reflects the greater variability among females as compared to males due to non-synchronized estrus cycles.  