(E) Architecture of the SMC complexes of S. cerevisiae. The Smc heterodimers (Smc1-Smc3, Smc2-Smc4, Smc5-Smc6) and kleisin (Scc1, Brn1, Nse4) subunits of cohesin, condensin and the Smc5/6 complex are indicated. 