(H) FOXD3 represses MERVL and MSR in mouse ES cells: FOXD3 (green) binds to MERVL and MSR and recruits SUV39H1 (yellow) to the repeats. SUV39H1 facilitates repression of the repeats by establishing H3K9me3 (orange hexagons). Foxd3 depletion disrupts the recruitment of SUV39H1 and leads to a reduction in H3K9me3 over MERVL and MSR. This in addition to an increase in H3K4me3 (green hexagons) on the region results in the activation of MSR and MERVL and a concomitant increase in 2CLC specific genes, shifting the balance between mESCs (Green and purple) and 2CLCs (Brown and blue). This is accompanied by a perturbation of the classical condensed heterochromatic foci in the nucleus. Foxd3 thus helps maintain ES cells in a pluripotent state by regulating MERVL and MSR. 