A: Rat primary cortical neurons were transduced with GFP-TDP-25 wild-type, GFP-TDP-43 or GFP at DIV5. Due to high toxicity, GFP-TDP-43 (n=6) and GFP control samples (n=6) were harvested at DIV5+4, while GFP-TDP-25 (n=5) and additional GFP control samples (n=6) were harvested at DIV5+8. Immunoprecipitates were analyzed by LC-MS/MS. Volcano plots indicate enrichment and statistical significance (grey dots: FDR-corrected p<0.05). Proteins associated with GO term "proteasome complex" (GO:0000502) are labeled in orange and proteins associated with GO term "RNA splicing" (GO:0008380) in purple. Full data is listed in Table S1. A comparison with previous proteomic studies is shown in Fig. EV3A. 