(E) Finally, CLIP produces a profile of all the genes that are identified as CCS. In total, 13 different modality features were assessed by the CLIP framework, provided there are data available for a cell line for all the molecular datatypes. All genes identified as a CCS gene in any modality are highlighted, light orange for up-regulation and light blue for down-regulation. Genes that have CCS evidence across two or more modality types are considered in our analyses as robust Cancer Context Specific (rCCS) genes, highlighted as light green. 