Bottom: overview of the APC/C-Nek2A structure is shown coloured as in Fig 2. Top: close up of the Apc2 and Apc4 binding site for Nek2A in the APC/C-Nek2A structure (this study, left), APC/CUbcH10-Hsl1 structure [27] and APC/CMCC structure [14]. 