(H) Model of the role of CENP-B in the maintenance of centromere identity. I-III: See text for details. In III: (top) representative image of a pseudo-dicentric chromosome in PD-NC4 cells with an active (red) and inactive (green) centromere bound by CENP-C and CENP-B, respectively; (bottom) example of a rare centromere re-activation in which the inactive (red) centromere gains CENP-C binding capacity. White dashed lines contour representative chromosomes. Schematic to the right illustrate the observed CENP-C and CENP-B localization patterns on a chromosome. 