(B) Experimental set-up. Irf3‑/‑Irf7‑/‑ recipient mice were lethally irradiated and reconstituted with WT (GFP+) and Irf3‑/‑Irf7‑/‑ (GFP‑) bone marrow cells (BMCs) mixed at different ratios. Chimeras were injected in the footpad 4 weeks later with poly(I:C) and WT and Irf3‑/‑Irf7‑/‑ DCs from non‑draining and draining popliteal lymph nodes were analyzed 24h after poly(I:C) injection by flow cytometry. 