  Figure 7. Schematic of the proposed mechanism for prominin2 induction mechanism by lipid peroxidation. The lipid peroxidation metabolite 4HNE activates p38/MAPK to phosphorylate and activate the stress-responsive transcription factor HSF1. The consequent increase in prominin2 expression promotes ferroptosis resistance and this mechanism can be targeted to enable resistant cells to succumb to ferroptosis. Figure partially created using BioRender.  