A. Experimental scheme for B-G. Whole-cell patch-clamp recordings were made from neurons in CA1 of organotypic hippocampal slices treated with inactive control, GSK3α or GSK3β inhibitor, or AR-18 (all at 10 µM). EPSCs were elicited with CA3 Schaffer collateral stimulation, and low-frequency stimulation (LFS) was used to induce LTD. For inactive control, GSK3α and GSK3β inhibitor compounds, the experiment was performed blind with respect to treatment group. 