C Schematic for the structure of stress-activated MAPK pathway (adapted from (Hotamisligil & Davis, 2016) and (Davis, 2000)) with the two branches of MAP-kinases (p38 and JNK) and their upstream kinases (MKK3, MKK4, MKK6 and MKK7). Arrows show the target MAPK branch for each MAPKK. The role of MAP2K4 in p38 phosphorylation is unclear (Hotamisligil & Davis, 2016) and is presented with dashed line. Changes in thermal stability after heat shock are marked with ovals. 