G, Metabolic reactions of glycolysis and the urea cycle; differentially expressed (treated patients vs. healthy tissue; Benjamini-Hochberg-adjusted p < 0.1) enzymes are highlighted in red. An empirical Bayes moderated t-statistic was computed from a gene-wise linear model fit with generalized least squares , comparing treated patients (n=4 samples), which cluster closely with the mouse samples (encircled in f), with healthy breast tissue (n=10 samples). Differential expression data from mouse in vitro transcriptome data of residual versus normal samples (RNA-seq; normal, n=8; residual, n=4) are shown (two-sided Wald test (Love et al., 2014), Bonferroni-adjusted p < 0.1). 