F, Summary figure integrating transcriptomics (normal, n=8 mice; tumor and residual, n=4 mice each), intracellular (Int.) metabolomics (normal, tumor, and residual, n=8 mice each; WT, n=2 mice), extracellular (Ext.) metabolomics of spent growth medium (normal, n=4 mice; WT, n=2 mice; tumor and residual, n=3 mice each) and DNA methylomics (normal, n=2 mice; tumor and residual, n=3 mice each) from the three populations. Color depth represents the normalized Euclidean distance of the respective omics layer in reference to normal. Distances between the centers of the three populations correspond to the normalized mean Euclidean distances across all represented omics layers. 