E, Principal component analysis of normal and WT (blue), tumor (orange), and residual (green) populations based on intracellular metabolomics targeted at central carbon metabolism (n=8 each; WT n=2). Data information Number of replicates corresponds to individual mice used to derive organoids. Centroids represent the mean and concentration ellipses represent one standard deviation (level=0.68) of an estimated t-distribution based on the first two principal components. 