(A) Principal components analysis of 16S rRNA gene-sequencing analysis of gut microbes obtained from Villin-Cre and COPS8-lox alleles expressing (COPS8fl/f ) and COPS8 knockout (KO) (COPS8ΔIEC) mice. PC1 and PC2 explain the 64.47% and 27.95% variation, respectively. Representative data from five biological replicates per genotype. 