(E) The marker for enteroendocrine cells (between two dashed line), chromogranin, was detected by immunofluorescence and counted in the ileum of COPS8fl/fl and COPS8ΔIEC mice (scale bar 100 μm). The column graph represents number of chromogranin A+ cells per crypt-villus presented as mean ± SEM from seven biological replicates. *P<0.05 using Student's t-test. 