Calculated Kon, Kdis and KD values for Aβ42 oligomers or Aβ42 monomers, Aβ40 monomers, APOE3 or APOE4 association/dissociation with soluble TREM2-Fc and AD variants. Kinetic constants were calculated using five different concentrations of ligand and the entire experiment (including new ligand preparations and purifications of soluble TREM-Fc) was repeated twice (# p < 0.05, ANOVA, Tukey's Multiple Comparison Test, see Appendix table S1 for p value) 