 α-Syn is released from neurons, taken up into neighboring neurons and accumulated with endogenously expressed α-syn. In donor cells, c-src impairs autophagy, thus facilitating α-syn release. In recipient cells, c-src enhances the uptake of α-syn by regulating endocytosis. Accordingly, c-src plays a dual role in cell-to-cell transmission of α-syn. It regulates the uptake of α-syn via endocytosis. It also regulates the release and intracellular accumulation of α-syn via autophagy. 