B Experimental design for treatment in metastatic settings: 5 months after injection, mice were randomized to vehicle (n=4) or BAPN (n=4) treatment (top). Radiance-based tumor growth curves (mean ± SE) for MM134 (left) and SUM44 (right) xenografts treated in the metastatic setting (bottom). For statistical analysis, mixed-effects linear models with spline regression (when applicable) were used on log10(radiance) curves Likelihood-ratio tests from the ANOVA function in R were used for model comparison, i.e. to check whether the treatment/group covariate is significant. *** p < 0.001 (likelihood ratio statistic associated p-value). 