(E-F) Effect of pairwise motif knockout (log2 scale) in core promoters CG7712 (E) and pain (F), respectively. The heatmaps display the mean expression fold changes compared to wild-type expressions for pairwise knockout of motifs compared to individual knockouts (diagonals). Additivity was calculated as the difference between the pairwise effect and the sum of two individual effects, Subadditive (in blue): > 0; superadditive (in yellow): < 0; Additivity values for effects > 3×SDnoise shown in the right lower corner of each pairwise effect.  