Top: cylinder representation of the APC/C-Nek2A complex structure. The TPR lobe subunits are highlighted: Apc8 (cyan), Apc6 (pink), Apc3 (yellow) and Apc7 (green). The platform subunits and the small subunits from the TPR lobe are shown in transparency. Bottom: cryo-EM density of the Nek2AMR tail dipeptide and details of the Nek2AMR tail (orange) binding site on Apc8A.   Details of the IR tail of Cdc20MCC (orange) bound to Apc8A in APC/CMCC-closed. This is the same site as the Nek2AMR tail-binding site shown above. Shown is the cryo-EM density for the Cdc20MCC IR tail and contacting residues of Apc8A.   