(A) Graph showing loss of weight following oral dextran sodium sulfate (DSS) (2%) treatment with and without mulberry bark derived exosome-like nanoparticles (MBELNs) for 7 days (10 x 109 particles/dose/day/mouse) once daily for 7 days in Villin-Cre and COP9/COP9 constitutive photomorphogenic homolog subunit 8 (COPS8)-lox alleles expressing (COPS8fl/fl) and COPS8 knockout (KO) (COPS8ΔIEC) mice. Changes in body weight are presented as percent of initial weight determined using Mann-Whitney test, *P<0.05, **P<0.01, NS- non-significant. Representative data from seven biological replicates per genotype. 