MYC down-regulates the m6A modification preferentially in certain MRGs, by up-regulating the demethylase ALKBH5. The m6A reader YTHDF3-mediated translation of MRGs SPI1 and PHF12 is attenuated as decreased m6A modification, and thus releases the inhibitory effect of MRGs on cell proliferation, thereby promoting cancer progression. The up-direction red arrows indicate high and down-direction red arrows indicate low. 