D, Heat map of untargeted metabolomics results showing the clustering of the normal - wild type (dark blue), normal - uninduced (light blue), tumor (yellow) and residual (green) populations and the most altered metabolic pathways (n=4). Hierarchical clustering was based on the complete linkage method using the Euclidean distance metric. Significance is defined as a false discovery rate < 0.05 versus the normal population, calculated using unpaired two-sided t-tests and adjusted for multiple hypothesis testing according to Storey's and Tibshirani's method PPP, pentose phosphate pathway; TCA, tricarboxylic acid cycle; OXPHOS, oxidative phosphorylation; AA, amino acids. Data information: Number of replicates corresponds to individual mice used to derive organoids. 