A Fold-change of each annotated mRNA (log2FC, relative to the EV control), plotted against its q-value (-log10). mRNAs showing significant up- and down-regulation (qval<0.05) are marked in red and blue, respectively. The values reported in the graphs indicate the total numbers of up- and down-regulated genes (qval<0.05) and of the subset regulated above a defined threshold of |log2FC|>0.5. 