A Definition of aggregating proteins. Solubility is measured as the log2-transformed ratio of protein intensities in the soluble fraction between heat shocked and mock shocked samples. Proteins with significant reduction in solubility [Benjamini-Hochberg adjusted p-value < 0.05 and solubility < log2(2/3)] are then considered as aggregators. Dotted horizontal line shows the cut-off at solubility of log2(2/3). 