A PLX4032 dose-response curves of parental and resistant cells after YAP/TAZ knockdown. Cells were transfected with either control (siCon) or YAP plus TAZ (siYT#1) siRNAs for 72 hr, and then treated with PLX4032 at the indicated concentrations for additional 72 hr. Relative cell viability, compared with DMSO control, was measured by CCK8 assay. Sigmoidal dose-response curves were fitted to data, and significance of the difference in IC50 values were determined by extra sum-of-squares F test. 