A-B Interactors identified in MaMTH-HTS that, when knocked-down in CFBE cells, affect CFTR membrane trafficking. Interactors affecting A) F508del-CFTR and B) wt CFTR are indicated. Green bars (all with a Z-score greater than or equal to 1) indicate a significant enhancement of CFTR trafficking to the PM. Red bars (all with a Z-score of less than or equal to -1) indicate a significant reduction in CFTR PM trafficking. The 'rescued' trafficking effects of the corrector compounds lumacaftor (VX-809) and tezacaftor (VX-661) are shown, as dotted red lines, for comparison. All conditions were measured across n=4 biological replicates and the number of valid replicates is indicated between parenthesis for each condition. 