D Top five GO terms (cellular component) associated with genes upregulated in HEK293 mutant MRPS5 V336Y compared to HEK293 wild-type MRPS5. Corresponding GO terms associated with genes upregulated in mutant MT-RNR1 A1555G lymphocytes (Hollis et al, 2015) were plotted. The bars represent the percentage of genes that map to a GO term and which are upregulated. Fisher exact t-test, +p<10-6, ++p<10-7, +++p<10-8 (MRPS5 V336Y n=4, MRPS5 wild-type n=6); *p<10-30, **p<10-40, ***p<10-50 (A1555G n=28, wild-type n=15). 