Figure 1: Impaired fear extinction precedes memory decline in Fmn2 mutant mice.A. Freezing behavior tested 24h after training was similar in 3-month old APPPS1-21, 5xFAD and Fmn2 -/- mice when compared to corresponding control groups (n = 10/group).E. Freezing behavior was tested 24h after training in 8-month old APPPS1-21, 5xFAD and Fmn2 -/- mice. A significant impairment in associative memory was observed when comparing APPPS1 mice (n=10) to a corresponding control group (n=8; P** < 0,01), when comparing 5xFAD mice (n=10) to a corresponding control group (n=8; P** = 0,01) and when comparing Fmn2 -/- mice (n=10) to corresponding Fmn2 +/+ wild type mice (n=10; P*** < 0,0001). 