GUARDIN acts as an RNA scaffold to facilitate interaction between LRP130/PGC1α that acts to transcriptionally repress FOXO4 expression. This repression prevents FOXO4-mediated upregulation of p21 and cell entry into senescence. GUARDIN participates in rapamycin-induced cellular senescence, likely through downregulation by FOLS2, which is also downregulated by rapamycin. 