(A) RNA-seq reads from brain of homozygous knock-in (FusΔNLS/ΔNLS, upper panel), homozygous knock-out (Fus-/-, middle panel) and control (Fus+/+, lower panel) mice showing the absence of exon 15 (red arrow) in Fus mRNA in FusΔNLS/ΔNLS mice while the entire Fus transcript is absent in Fus-/-mice (green arrows). 