(E) Non-denaturing PAGE characterisation of the conformational state of M and Z α1-antitrypsin, after rapidly refolding by snap dilution from 6M urea in the presence or absence of GSK716 at the molar ratios indicated. The migration of polymers (pol) and monomers (mon) are shown. Arrows indicate the misfolded by-product M* arising at sub-stoichiometric concentrations of compound. 