Cartoon representation of the CCHFV vOTU crystal structure (PDB 3PHW) colored in a rainbow gradient from N- to C-terminus. The catalytic triad residues are marked on both the structure and the linear color gradient above, showing their positions with respect to each other and the overall OTU sequence. The closed black arrow marks a closed loop, while the open grey arrow marks the open N- and C-termini. A schematic for the permutated vOTUP variant is shown to illustrate how it relates to the native sequence topology. 