(C, D) Quantification of the discrimination error rate in the first 100 visits during the drinking phase of the six reversal sessions of adult wildtype (WT) and 11B mice (male, C; female, D) in the IntelliCage. Overall reversal place learning performance and memory flexibility of WT and 11B mice were analysed using two-way ANOVA. For males (C), WT vs. 11B, ** P = 0.004358; data over time, **** P < 0.0001; interaction, P > 0.05. For females (D), WT vs. 11B, ** P = 0.000578; data over time, **** P < 0.0001; interaction, P > 0.05. Differences between WT and 11B mice at each individual training day were compared by Fisher's LSD tests following two-way ANOVA, * P < 0.05. P = 0.0037718 (C, day 10), P = 0.043855 (C, day 24); P = 0.018903 (D, day 12), P = 0.045954 (D, day 29); P = 0.041434 (D, day 330). Note that (i) the two male sessions and the two female sessions yielded essentially the same results, and (ii) not shown in panels the two separate male sessions yielded essentially the same results, and the two separate female sessions yielded essentially the same results. 