Annotated MaMTH-HTS interactome for wt- and F508del-CFTR (green, red and blue edges) expanded with known experimental and predicted interactions from IID v 2021-05 (black/gray edges). Interactions observed in MaMTH-HTS to be shared by both wt and F508del CFTR are indicated by blue edges, while those observed with only wt or F508del are indicated by green and red edges, respectively. Node color represents Gene Ontology Biological process. Black square outline and larger node label indicate CFTR interactions overlapping with IID. Node label colouring highlights interactors functionally validated in this work. 