(A) Schematic representation of proposed mechanism by which MPC inhibition engages the malate-aspartate shuttle (MASh). GOT1/2, glutamic-oxaloacetic transaminase; OGC1, oxoglutarate carrier 1; Aralar, mitochondrial aspartate-glutamate carrier; CPT, Carnitine Palmitoyltransferase. The coordinated work of OGC1 and Aralar provide a mechanism to allow fatty acid oxidation in the absence of pyruvate. Fatty acid oxidation generates acetyl-CoA which condenses with oxaloacetate to generate citrate. In the absence of pyruvate, oxaloacetate can be generated by glutamine metabolism. 