(A) Volcano plot of up - (log2-fold change for transcripts with counts per million, CPM >1; red dots) and downregulated (log2-fold change CPM <1; blue dots) transcripts in LV after Cand2 KO. Differential expression analysis performed with edgeR; Benjamini-Hochberg method for p-value calculation, cut off 0.05. Cand2 and Grk5 marked among depleted transcripts in Cand2 KO vs. WT mice. Enrichment of Kyoto Encyclopedia of Genes and Genomes (KEGG Pathways) terms for differentially expressed genes in LV of Cand2 KO vs. WT mice. 