(H-I) Western blot showing expression of COPS8 in wildtype (Wild) and AhR-KO MC38 cells and expression of AhR in wild and COPS8-KO MC38 cells. MC38 cells were KO using CRISPR/ CAS9 KO plasmid transfection. Data represents mean ± SEM from three biological replicates, **P<0.01, NS- nonsignificant, using one-way ANOVA. 