E TNT formation was quantified between non-drug treated cells (yellow), chemo-drug treated cells (blue) or between non-drug treated and chemo-drug treated cells (red) following confocal microscopic imaging (non-drug treated cells: white circles, chemo-drug treated cells: black circles). In the co-culture assay, TNTs in shCtr, shM2#1 and shM2#2 groups (n=485, 618 and 581 respectively) were imaged. Three independent experiments were performed. Data information: data were analyzed using two-way ANOVA with Bonferroni post-test and shown as mean ± SEM; * P < 0.05, ** P < 0.01, *** P < 0.001, ns, not significant. 