(A) Targeting strategy for the conditional disruption of the Clppgene. Map of the genomic locus region of the wild type Clpp gene (wild type), the Targeting Vector, the Clpp locus after homologues recombination (Targeted Allele) and targeted allele after Flp-recombinase-mediated excision of the PuroR cassette (Conditional KO Allele- ClpploxP) and the knocked-out allele after Cre-recombinase-mediated excision of the exons 3-5 (Constitutive KO Allele - Clpp-). The position of primers used for genotyping is indicated by red arrows. 