B. The AUC of the ROC curves in A are shown as large dots, compared to random permutations (which preserve the counts of each cause and effect but randomize their pairings) of the edge list which are shown as small dots and a boxplot of these null AUCs. Permutations with values systematically in excess of a value of 0.5, as seen when predicting genetic interactions with rise time, are likely due to hub effects where genes that tend to be predicted regulators of many targets also tend to have interactions. 