B Luciferase activity analyses in wild-type (WT), or WTAP-/- 293T cells, transfected with a luciferase reporter for IFN-β (IFN-β-luc) or ISRE (ISRE-luc) followed by treatments with intracellular poly(I:C), poly(dA:dT), or VSV-eGFP. The results are expressed relative to Renilla luciferase activity. 