In this model, curcumin inhibits adipogenesis by reducing the expression of ALKHB5, an m6A demethylase, which leads to higher m6A-modified TRAF4 mRNA. TRAF4 mRNA with higher m6A level is recognized and bound by YTHDF1, leading to enhanced translation of TRAF4. TRAF4, acting as an E3 Ring ubiquitin ligase, promotes degradation of adipocyte differentiation regulator PPARγ by a ubiquitin proteasome pathway thereby inhibiting adipogenesis. 