Mode of regulation of transcription by Alu RNAs through suppression of RNA Polymerase II (left panel) and protein-accelerated self-cleaving processing properties of Alu RNAs (right panel) as described in previous studies (Hernandez et al., 2020; Mariner et al., 2008; Ponicsan et al., 2010; Yakovchuk et al., 2009). 