G, H Quantification of the percentage of the time spent in the center area of the open field arena (G), and quantification of the latency to enter the center area (H) of the open field arena. Data are the mean of 7 male (WT), 12 male (11B), 8 female (WT) and 9 female (11B) adult littermate mice. Error bars indicate SD, * P < 0.05. Two-tailed unpaired Student's t-test, P = 0. 0114 (G, male); Mann-Whitney test, P = 0. 0193 (H, male). Data information: The lack of statistical significance for female WT vs. 11B mice in the open field test presumably reflects the greater variability among females as compared to males due to non-synchronized estrus cycles.  