F, Joint clustering of sample-wise normalized pathway enrichment test statistics (unpaired one-side two-sample t-test) of mouse model (RNA-seq; normal, n=8; residual n=4) and patient (microarray; healthy, n=10, regressed n=20). Clustering is based on all genes of human KEGG pathways (or their mouse orthologs) that involve HER2 and are known to be deregulated in cancer Hierarchical clustering with the complete linkage method and the Euclidean distance as a distance metric was used for clustering. For the patient comparison, two independent datasets, one from healthy breast tissue (GSE65194) and one from patient tissues after neoadjuvant treatment (GSE32072) were merged. Data information: Numbers of replicates correspond to individual mice or humans. 