Processing areas of Alu RNAs on the secondary Alu RNA structure. Secondary structure of Alu RNA adapted from Hadjiargyrou and colleagues (Hadjiargyrou & Delihas, 2013). As in our previous studies (Cheng et al., 2020; Zovoilis et al., 2016), we depict the SINE RNA processing areas (highlighted in pink) based on short RNA-seq data and mapping of the 5'ends of Alu RNA fragments. X mark the cleavage sites of Alu RNA that correspond to enriched processing areas (the high densities of 5'end fragments distribution) at the heatmap of Figure 1B. The rectangle depicts the critical region that binds and suppresses RNA Pol II based on (Mariner et al., 2008) that may be affected due to processing points. 