Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity A.Figure 5Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticityA. Volcano plot showing genes differentially expressed in the dentate gyrus of either 3- (red) or 8-month (black) old Fmn2 -/- mice compared to corresponding wild type control group (FDR < 0,05, log2 fold change < +/- 0,25). The upper panel depicts the number of altered genes. Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity B. Top GO domains and pathways affected in 3-month old Fmn2 -/- mice when compared to wild type control animals. D. Top GO domains and pathways deregulated in 8-month old Fmn2 -/- mice when compared to an age-matched control animals. GO:CC; gene-ontology domain "cellular compartment", GO:MF; gene-ontology domain "molecular function", GO:BP; gene-ontology domain "biological process", pathway "KEGG pathways". Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity C. Expression of selected genes affecting the oxidative phosphorylation pathway that are increased in 3-month old Fmn2-/- mice (*P < 0,05; n=5/group). Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity E. Expression of selected genes of the oxidative phosphorylation pathway that were decreased in 8-month old Fmn2-/- mice (*P < 0,05; n=3-5/group). Error bars indicate SEM. Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity F. Cytoscape-generated network of genes deregulated in 8-month old Fmn2-/- mice. Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity G. Volcano plot showing differential exon usage in the dentate gyrus of either 3- (red) or 8-month (black) old Fmn2 -/- mice when compared to the corresponding wild type control group (FDR < 0,05, log2 fold change < +/- 0,2). The upper panel depicts the number of altered genes Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity H. Selected GO domains and pathways affected by differential exons usage in 8-month old Fmn2 -/- mice when compared to a wild type control group. GO:CC; gene-ontology domain "cellular compartment", GO:MF; gene-ontology domain "molecular function", GO:BP; gene-ontology domain "biological process", pathway "KEGG pathways". Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity I. Volcano plot showing genes differentially expressed in 3-month old APPPS1-21 mice compared to a wild type control group (green) and APPPS1-21_Fmn2 -/- mice compared to wild type control mice (purple). (FDR < 0,05, log2 fold change < +/- 0,5). The upper panel depicts the number of altered genes. Figure 5: Memory decline in 8-month old Fmn2 -/- mice correlates with deregulated transcriptome plasticity J. Functional pathways affected when comparing APPPS1-21 (green bars) or APPPS1-21_Fmn2 -/- mice (purple bars) to wild type mice. GO:CC; gene-ontology domain "cellular compartment", GO:MF; gene-ontology domain "molecular function", GO:BP; gene-ontology domain "biological process", pathway "KEGG pathways".