EMBO/SourceData huggingface dataset:
Figure legend: "A. Immunohistochemical (IHC) staining of viral spike proteins in lung sections from K18-hACE2 mice (Winkler et al., 2020) at day 5 post-infection. Spike proteins were detected with anti-spike antibody and stained brown. Images of bronchial epithelium of vehicle control treated (i and ii) and C6G25S treated (iii and iv), alveoli of vehicle control treated (v and vi) and C6G25S treated (vii and viii), bronchiole and blood vessel of vehicle control treated (ix and x) and C6G25S treated (xi and xii) group were shown. Syncytial cell was indicated by green arrow in (xi) and thrombosis in (x)."
NCBI gene IDs:
"C6G25S: 43740578"
Figure legend: "B. ISH staining of viral RNA in lungs of vehicle control group (left) and C6G25S treated group (right) at day 2 post-infection. Viral RNA was stained brown as green arrows indicated. Images are representative of 5 animals for each group."
NCBI gene IDs:
"C6G25S: 43740578"
Figure legend: "C. Images of IHC staining of Ly6G+ Cells (Brown color, arrows indicated) in lungs of vehicle control (left) and C6G25S treated group (right) at day 2 post-infection."
NCBI gene IDs:
"C6G25S: 43740578"
Figure legend: "D. Images of IHC staining of F4/80+ Cells (Brown color) in lungs of vehicle control (left) and C6G25S treated group (right) at day 2 post-infection. E. Images of IHC staining of CD3 + T Cells (Brown color, arrows indicated) in lungs of vehicle control (left) and C6G25S treated group (right) at day 2 post-infection. F"
NCBI gene IDs:
"C6G25S: 43740578"
Figure legend: " (B) Box plots show the MIG-6 (ERRFI1) gene expression in different breast tumor subtypes in the Servant dataset of 343 primary breast cancer carcinomas, analyzed using Illumina HumanWG-6_v3 Arrays. The gene expression levels are determined using the R2 Genomics Analysis and Visualization Platform (http://r2.amc.nl). In the box plot, error bars are the 95% confidence interval, the bottom and top of the box are the 25th and 75th percentiles, the line inside the box is the 50th percentile (median), and any outliers are shown as open circles. **p &lt; 0.01, by Student's t-test. "
NCBI gene IDs:
"ERRFI1: 54206
MIG-6: 54206"
Figure legend: " (A) Cell proliferation and immunoblotting assays in BT549 cells with Luciferase or MIG-6 knockdown. "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (B) Cell proliferation and immunoblotting assays in MDA-MB-231 cells with Luciferase or MIG-6 knockdown. "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (C) Representative images and quantification results for a colony formation assay in BT549 cells with GFP or MIG-6 knockdown. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (D Immunoblotting analysis for EGFR signaling in BT549 cells with GFP or MIG-6 knockdown. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " E) Immunoblotting analysis for EGFR signaling in MDA-MB-231 cells with GFP or MIG-6 knockdown. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (F) Cell growth assay in BT549 cells with GFP or MIG-6 knockdown in the absence and presence of gefitinib for 72 hours. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (B) Extracellular acidification rate (ECAR) in BT549 cells with GFP or MIG-6 knockdown. The ECAR flux profile of GFP and MIG-6 knockdown BT549 cells upon stimulation of glucose, oligomycin, and 2-DG is shown on the left. Quantitative results for the basal glycolysis and maximal glycolysis capacities in GFP and MIG-6 knockdown BT549 cells are indicated by orange and green boxes, graphed on the right. Results are presented as mean ± SEM (n=15; biological replicates). "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (C) A heatmap diagram shows the expression profile of genes involved in glycolysis, the TCA cycle, the pentose phosphate pathway, pyruvate oxidation, gluconeogenesis, and glycogen metabolism obtained from two sets of GFP and MIG-6 knockdown BT549 cells. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " Histograms show the percentage of gene dysregulation in glycolysis, TCA cycle, upon MIG-6 knockdown in BT549 cells. For each gene, the change was calculated based on the equation: (shGFP-shMIG6)/shMIG-6. Results are presented as mean ± SEM (n=3; biological replicates). "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
MIG6: 54206"
Figure legend: " F) Histograms show the percentage of pyruvate oxidation pathways upon MIG-6 knockdown in BT549 cells. For each gene, the change was calculated based on the equation: (shGFP-shMIG6)/shMIG-6. Results are presented as mean ± SEM (n=3; biological replicates). "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
MIG6: 54206"
Figure legend: " (H) Lactate production assay in BT549 cells with GFP or MIG-6 knockdown (n=3). The medium was collected to measure lactate concentration using lactate test strips and an Accutrend Lactate analyzer. The rate of lactate production was determined (lactate production rate = lactate concentration/cells/time) and normalized to the rate detected in the control group. The quantified results are presented as mean ± SEM (n=3; biological replicates). "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (A) Box plots show the GLUT1 (SLC2A1) gene expression in different breast tumor subtypes in the Servant dataset of 343 primary breast cancer carcinomas, analyzed using Illumina HumanWG-6_v3 Arrays. The gene expression levels are determined using the R2 platform. In the box plot, error bars are the 95% confidence interval, the bottom and top of the box are the 25th and 75th percentiles, the line inside the box is the 50th percentile (median), and any outliers are shown as open circles. **p &lt; 0.01, by Student's t-test.. "
NCBI gene IDs:
"GLUT1: 6513
SLC2A1: 6513"
Figure legend: "(B) Real-Time PCR analysis for GLUT1 and MIG-6 mRNA expression in GFP and MIG-6 knockdown BT549 cells (n=3)."
NCBI gene IDs:
"GFP: 
MIG-6: 54206
GLUT1: 6513"
Figure legend: " (C) Immunoblotting analysis for GLUT1 protein expression in BT549 cells with GFP or MIG-6 knockdown. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (D) Confocal image analysis results for membrane-bound GLUT1 in GFP and MIG-6 knockdown BT549 cells are shown in the top panel. The arrow indicates membrane-localized GLUT1. Scale bar, 25 μm. Quantitative analysis results of the percentage of GFP and MIG-6 knockdown BT549 cells expressing membrane-localized GLUT1 are shown in the bottom panel (n=3). "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (E) Representative flow cytometry images (upper) and quantitative results (lower) of measuring glucose uptake in GFP and MIG-6 knockdown BT549 cells (n=3). Cells were grown in the presence of the fluorescent analog 2-NBDG for various time periods, and glucose uptake was quantified using flow cytometric analysis. The red box indicates the gating for 2-NBDG+ cells and the number indicates the percentage of 2-NBDG+ cells. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (F) Immunoblotting analysis for GLUT1 protein expression in GFP and MIG-6 knockdown BT549 cells with or without MG132 treatment. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (B) Immunoblotting analysis for HIF1α protein expression in BT549 cells with GFP or MIG-6 knockdown. (C) Immunoblotting analysis for HIF1α protein expression in MDA-MB-231 cells with GFP or MIG-6 knockdown. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (D) Real-Time PCR analysis for HIF1α mRNA expression in BT549 cells with GFP or MIG-6 knockdown. The quantified results are presented as mean ± SD (n=4). ***p &lt; 0.001, by Student's t-test. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
HIF1α: 3091"
Figure legend: " (E) Immunoblotting analysis for HIF1α protein expression in GFP and MIG-6 knockdown BT549 cells in the absence or presence of the proteasome inhibitor MG132. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (F) GFP and MIG-6 knockdown BT549 cells transfected with the indicated plasmids were treated with MG132, subjected to immunoprecipitation (IP) with Flag-tag or HIF1α antibody, followed by immunoblotting analysis. MG132 was used to rescue HIF1α protein degradation mediated by MIG-6 knockdown, leading to similar HIF1α protein levels in control and MIG-6 knockdown BT549 cells, which were used as the input to examine the role of MIG-6 in the interaction between HIF1α and HAUSP. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206"
Figure legend: " (G) Luciferase and MIG-6 knockdown 293 cells were transfected with the indicated plasmids and subjected to MG132 treatment. Afterward, cells were harvested for IP with HA antibody, followed by immunoblotting analysis to determine the level of K48-linked ubiquitination of HIF1α. MG132 was used to preserve the degradative K48-linked ubiquitination signals. "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (H) Immunoblotting analysis for MIG-6 and HIF1α expression in Luciferase and MIG-6 knockdown 293 without MG132 treatment. "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (I) Immunoblotting analysis for GLUT1 protein expression upon MIG-6 overexpression in GFP and HIF1α knockdown BT549 cells. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
HIF1α: 3091"
Figure legend: " (J) Immunoblotting analysis for GLUT1 protein expression upon MIG-6 overexpression in GFP and HAUSP knockdown BT549 cells. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
HAUSP: 7874"
Figure legend: " (K) Immunoblotting analysis for HIF1α protein expression upon HAUSP overexpression in GFP and MIG-6 knockdown BT549 cells. "
NCBI gene IDs:
"GFP: 
MIG-6: 54206
HAUSP: 7874"
Figure legend: " (A and B) Lactate production assay in BT549 (A) and MDA-MB-231 (B) cells with Luciferase or GLUT1 knockdown. "
NCBI gene IDs:
"Luciferase: 
GLUT1: 6513"
Figure legend: " (C) Cell proliferation assay in BT549 cells with Luciferase or GLUT1 knockdown. "
NCBI gene IDs:
"Luciferase: 
GLUT1: 6513"
Figure legend: " (D) Cell proliferation assay in MDA-MB-231 cells with GFP or GLUT1 knockdown. "
NCBI gene IDs:
"GFP: 
GLUT1: 6513"
Figure legend: " (E and F) Immunoblotting analysis for GLUT1 protein expression in control and MIG-6 knockdown BT549 (E) and MDA-MB-231 (F) cells with or without GLUT1 overexpression. "
NCBI gene IDs:
"MIG-6: 54206
GLUT1: 6513"
Figure legend: " (G Lactate production assay in control and MIG-6 knockdown BT549 cells with or without GLUT1 overexpression. "
NCBI gene IDs:
"MIG-6: 54206
GLUT1: 6513"
Figure legend: " H) Lactate production assay in control and MIG-6 knockdown MDA-MB-231 cells with or without GLUT1 overexpression. "
NCBI gene IDs:
"MIG-6: 54206
GLUT1: 6513"
Figure legend: " (I and J) Cell proliferation assay in BT549 (I) and MDA-MB-231 (J) cells with control knockdown, MIG-6 knockdown, or MIG-6 knockdown plus GLUT1 overexpression. "
NCBI gene IDs:
"MIG-6: 54206
GLUT1: 6513"
Figure legend: " (A and B) In vivo primary tumor growth derived from BT549 cells with Luciferase or MIG-6 knockdown (six mice per group). Cells were injected into the mammary fat pads of nude mice, and tumor sizes were measured weekly by caliper. Kaplan-Meier plot analysis is used to determine the incidence of Luciferase or MIG-6 knockdown BT549-xenograft tumors (A). Volumes of Luciferase or MIG-6 knockdown BT549 tumors at week 10 are presented as mean ± SEM (B). "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (C In vivo primary tumor growth derived from MDA-MB-231 cells with Luciferase or MIG-6 knockdown (nine mice per group). Volumes of Luciferase or MIG-6 knockdown MDA-MB-231 tumors were measured weekly by caliper are presented as mean ± SEM "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " D) In vivo primary tumor derived from MDA-MB-231 cells with Luciferase or MIG-6 knockdown (nine mice per group). Tumor weights of MDA-MB-231-derived xenografts were measured at the endpoint (day 33) and are presented as mean ± SEM (D). "
NCBI gene IDs:
"Luciferase: 
MIG-6: 54206"
Figure legend: " (E) Immunoblotting analysis for MIG-6 expression in BT549 cells with MIG-6 inducible knockdown (iMIG-6-shRNA) and the non-targeting shRNA control (iNT-shRNA) upon doxycycline treatment. "
NCBI gene IDs:
"MIG-6: 54206"
Figure legend: " (F) In vivo primary tumor growth derived from BT549 cells containing iNT-shRNA and iMIG-6-shRNA (n=7 per group). The arrow indicates the time point when the diet was given to induce MIG-6 knockdown in vivo. Volumes of iNT-shRNA and iMIG-6-shRNA BT549 tumors are presented as mean ± SEM. "
NCBI gene IDs:
"MIG-6: 54206"
Figure legend: "(A) Representative images of histological analysis for GLUT1 protein expression in BT549-derived xenograft tumors. Scale bar, 100 μm. (B) Representative images of histological analysis for GLUT1 protein expression in xenograft tumors derived from BT549 cells containing iNT-shRNA and iMIG-6-shRNA. Scale bar, 100 μm."
NCBI gene IDs:
"MIG-6: 54206"
Figure legend: "(a) Expression of H2B-mCherry under control of the CLV3 promoter in 14-d-old seedlings. Whole-mount immunostaining using α-mCherry antibodies and laser scanning microscopy (scale bar 10 μm)."
NCBI gene IDs:
"CLV3: 817267"
Figure legend: "(c) A representative example for enrichment of CLV3 transcript in mCherry-positive nuclei determined by qRT-PCR and normalized to wt (N = 1)."
NCBI gene IDs:
"mCherry: 
CLV3: 817267"
Figure legend: "(a) Expression of CLV3, mCherry, TEL2, PAN, and the meristem marker genes STM and KNAT1. Asterisks indicate timepoints of significantly different expression (Wald test, Benjamini &amp; Hochberg corrected, q&lt;0.05) between stem and non-stem cells for each time point (N = 2). + = stem cell nuclei; - = non-stem cell nuclei, E = nuclei from embryos, D7/14/35 = nuclei from 7/14/35 day-old plants, S14 = nuclei from 14 d-old above-ground seedlings."
NCBI gene IDs:
"mCherry: 
CLV3: 817267
KNAT1: 826364
PAN: 843194
STM: 842534
TEL2: 843102"
Figure legend: "(a) Increased expression of TEs in stem cells of D7 seedlings according to qRT-PCR. Box plots outline the interquartile range (IQR) with the median and whiskers +/- 1.5 IQR. N = 2 (ATLANTYS3, ATCOPIA39, ATCOPIA49, ATCOPIA29, ATGP1-1), N = 3 (VANDAL6, ATGP2, ATGP1-2, ATLINE1, ATGP1-3), N = 4 (ATHILA6A, ATCOPIA83), N = 5 (VANDAL12, ATHILA3, ATCOPIA22), and N = 6 for CLAVATA. *p&lt;0.01, **p&lt;0.001 (t-test)."
NCBI gene IDs:
"ATCOPIA83: 
ATGP1-1: 
ATHILA3: 
ATHILA6A: 
VANDAL12: 
ATCOPIA22: 
ATCOPIA29: 
ATCOPIA39: 
ATCOPIA49: 
ATGP1-2: 
ATGP1-3: 
ATGP2: 
ATLANTYS3: 
ATLINE1: 
CLAVATA: 
VANDAL6: "
Figure legend: "(b) Heatmap of TE expression in several silencing mutants determined by qRT-PCR relative to a housekeeping gene. To be able to display data in log-scale also for samples with zero expression, a value of 1.0e-6 (factor 10 smaller than the smallest value) was added to all values. Data for nuclei and CLV3::H2BmCherry are the same as in (a). For seedling samples, N = 2 (ATCOPIA49, ATHILA3), N = 3 (ATCOPIA39, VANDAL6, ATGP2, ATLINE1, ATCOPIA29, ATGP1-1), and N = 4 (ATLANTYS3, VANDAL12, ATGP1-2, ATHILA6A)."
NCBI gene IDs:
"ATCOPIA29: 
ATCOPIA39: 
ATCOPIA49: 
ATGP1-1: 
ATGP1-2: 
ATGP2: 
ATHILA3: 
ATHILA6A: 
ATLANTYS3: 
ATLINE1: 
VANDAL12: 
VANDAL6: 
mCherry: 
CLV3: 817267
H2B: 832352"
Figure legend: "TCF-reporter TOP-flash assay performed on the indicated cell lines treated with 10 μM CHIR, for 24 hrs. The control FOP-flash reporter is not activated upon CHIR administration. The data represent the mean ± s.e.m. of averages of nine independent experiments (N = 9). dBcat, β-catenin knockout cells; d4TCF, TCF/LEF quadruple knockout cells Transfection of individual TCF-expressing plasmids could restore the ability of d4TCF cells to respond to Wnt3 as measured in a TOP-flash assa"
NCBI gene IDs:
"β-catenin: 1499
LEF: 51176
TCF: 6932
TCF: 83439"
Figure legend: "Quantitative RT-PCR analyses of Axin2 transcripts, performed on the different cell lines treated with 10 μM CHIR or DMSO (control) for 24 hrs. Error bars show that standard deviation obtained from 3 independent experiments Transfection of individual TCF-expressing plasmids could restore the ability of d4TCF cells to respond t CHI as measured by Axin2 mRNA abundance"
NCBI gene IDs:
"Axin2: 8313
TCF: 6932"
Figure legend: "(A, B) β-catenin occupancy on regulatory regions of the prototypical Wnt target genes, AXIN2 and LEF1 (A), and at the promoter regions of HOXC4 and ZNF503 (B)"
NCBI gene IDs:
"AXIN2: 8313
HOXC4: 3221
LEF1: 51176
ZNF503: 84858"
Figure legend: "(C) β-catenin ChIP-seq enrichment over ENCODE TCF7L2 (also known as TCF4) ChIP peaks in HEK293T cells. The data represent the mean ± 95% C.I. obtained from three independent experiments (N = 3)"
NCBI gene IDs:
"TCF4: 6934
TCF7L2: 6934"
Figure legend: "b RT-qPCR validation of the β-catenin-GHOST response. A selection of 7 genes (colour coded) that are activated upon CHIR treatment in d4TCF, or in wild-type (WT) in combination with ICAT overexpression, but not in pentaKO cells - indicating that their regulation is dependent on β-catenin but can only occur in the absence of TCF/LEF-β-catenin interaction. The genotype and the treatment for each condition is indicated in the x-axis. Error bars show that standard deviation obtained from 3 independent experiments"
NCBI gene IDs:
"β-catenin: 1499
ICAT: 56998"
Figure legend: "c FOXO4 but not FOXO3 overexpression upregulates the β-catenin-GHOST target GADD45 both in CHIR-treated WT (black bars) or d4TCF (grey bars) cells. Samples were compared using Student\"s t-test. Asterisks (*) indicate a p-value&lt;"
NCBI gene IDs:
"FOXO3: 2309
FOXO4: 4303
GADD45: 10912///1647///4616"
Figure legend: "d FOXO4 overexpression induced GADD45 transcription in WT (black bars) but not in dBcat (grey bars) cells. Samples were compared using Student\"s t-test. Asterisks (*) indicate a p-value&lt;"
NCBI gene IDs:
"FOXO4: 4303
GADD45: 4616///1647///10912"
Figure legend: "e Endogenous FOXO4, when immunoprecipitated (IP) pulls down β-catenin. Overexpressed FOXO4 increases the amount of β-catenin detected in the immunoprecipitated, indicating physical association"
NCBI gene IDs:
"FOXO4: 4303"
Figure legend: "f GADD45 is upregulated by CHIR in d4TCF cell; this positive transcriptional regulation is blocked by FOXO4-specific siRNA but not control scrambled siRNA. All experiments were done at least three times (N=3). Samples were compared using Student\"s t-test. Asterisks (**) indicate a p-value&lt;0.02; ns, non-statistically significant change was obs"
NCBI gene IDs:
"FOXO4: 4303
GADD45: 4616///1647///10912"
Figure legend: "(C) Time-lapse microscopy of cells containing a PsigV-YFP promoter reporter reveals heterogeneous activation of σV in response to lysozyme stress. The stress (red line) was added between the 200 mins and 300 min time points (at 240 min). The red arrow highlights a cell with a delayed activation of σV. Scale bar: 5 μm."
NCBI gene IDs:
"YFP: 
sigV: 937591"
Figure legend: "(B, C) RNA-seq experiment on WT (JLB130) and ΔsigV (JLB154) strains, showing quantification of the absolute expression of individual genes in the presence and absence of lysozyme stress. The shaded grey box represents a ± 5 fold change. DEseq was used to identify genes which were differentially expressed with a 5% p-value cutoff between the WT and ΔsigV mutant in response to lysozyme treatment (default DEseq test was used). (B) Only the sigV operon is strongly activated (&gt;5 fold change) in response to lysozyme stress in WT (JLB130), as previously reported (Guariglia-Oropeza and Helmann 2011). (C) No genes were strongly upregulated in ΔsigV (JLB154) by lysozyme stress."
NCBI gene IDs:
"sigV: 937591"
Figure legend: "(D) Effect of the overexpression of individual components of the σV pathway (Biological repeats: WT: n=8, sigV+: n=4, rsiV+: n=3 oatA+: n=4, yrhK+: n=3, sipS+: n=3 and rasP+: n=3, pbpX+: n=6) on the fraction of activated cells. Only overexpression of sigV, rsiV or oatA changed the observed dynamics compared to WT. The histograms of the shown data are shown in Appendix Figure S16. (E) Deleting oatA did not alter the σV activation dynamics. However, deleting sigV or rsiV resulted in no further activation of σV in response to 1 ug/ml lysozyme. n&gt;=3 biological repeats for all data shown. The histograms of the shown data are shown in Appendix Figure S17. ( "
NCBI gene IDs:
"oatA: 936583
pbpX: 939677
rasP: 939612
rsiV: 937593
sigV: 937591
sipS: 938944
yrhK: 937587"
Figure legend: "(C) As predicted, the 2xsigV or 2xsigV-rsiV stains have a homogenous σV response to 1 µg/ml lysozyme, while the 2xrsiV strain has increased heterogeneity. Each bar plot is the average of three biological repeats. The bars correspond to the mean ± s.d.."
NCBI gene IDs:
"rsiV: 937593
sigV: 937591"
Figure legend: "(C) Expression of miRNAs miR-146a and miR-505 correlated with overall survival in ovarian cancer patients. The validation cohort (n=150 samples) is shown. See Figure EV1 for the training cohort."
NCBI gene IDs:
"miR-146a: RF00691
miR-505: RF00781"
Figure legend: "(A) The consequence of miR-155 and miR-181b mimics on cell viability, 5 days post transfection, relative to a negative control miRNA mimic is shown across a panel of normal and ovarian cancer cell lines as indicated. Each data point is the mean of n=3/cell line. In the screen, miR-155 was found to reduce cell viability (Z-score &lt; -2) in one cell line, and TCGA expression data revealed no significant change in expression of this miRNA in ovarian tumors. miR-181 was found to reduce viability (Z-score &lt; -2) in 2 cell lines, and TCGA expression data revealed no significant change in expression of this miRNA in ovarian tumors. N, normal cell lines (IHH, HOSE, HBEC3, HBEC13, HBEC30, and HBEC34), EOC, epithelial ovarian cancer cell lines. miR-155 data points for each cell line are shown in black while miR-181b data points are displayed in red."
NCBI gene IDs:
"miR-155: RF00731
miR-181: RF00076
miR-181b: RF00076"
Figure legend: "(B) Immunoblots indicate suppression of serum-induced AKT phosphorylation at S473 and T308 in response to miR-155 and suppression of T308 phosphorylation in response to miR-181b."
NCBI gene IDs:
"miR-155: RF00731
miR-181b: RF00076"
Figure legend: "(C) miR-155 and miR-181b reduced cell viability in GDC0941-sensitive breast cancer cell lines. Error bars indicate mean ± SD (n=3)."
NCBI gene IDs:
"miR-155: RF00731
miR-181b: RF00076"
Figure legend: "(F) Cell viability upon expression of miR-155 or miR-181a mimics in 41 NSCLC cell lines and 5 human bronchial epithelial cell lines. Each data point is the mean of n=3/cell line. R2 from Pearson correlation."
NCBI gene IDs:
"miR-155: RF00731
miR-181a: RF00076"
Figure legend: "(A) Consequence of miR-517a on EOC cell viability and 41 NSCLC cell lines (as in 2A). N, normal cell lines (IHH, HOSE, HBEC3, HBEC13, HBEC30, and HBEC34). miR-517a was found to significantly reduce cell viability (Z-score &lt; -2) in 5 cell lines in the screen, and TCGA expression data revealed no significant change in expression of this miRNA in ovarian tumors."
NCBI gene IDs:
"miR-517a: 574479"
Figure legend: "(B, C) In vivo delivery of neutral liposome incorporated miR-517a mimic reduced tumor burden by weight (B) and nodule number (C) in an orthotopic xenograft model using SKOV3 cells. Box-and-whisker plot from n=8. p-value from Student's T-Test. LD, low-dose (200 μg/kg); HD, high-dose (400 μg/kg)."
NCBI gene IDs:
"miR-517a: 574479"
Figure legend: "(D) Correlation of the consequence of ARCN1 depletion and miR-517a sensitivity in 12 NSCLC cell lines (plot as in 2D)."
NCBI gene IDs:
"ARCN1: 372
miR-517a: 574479"
Figure legend: "(E) Immunoblots indicate miR-517a-induced depletion of ARCN1 and USP1 in the indicated cell lines."
NCBI gene IDs:
"miR-517a: 574479"
Figure legend: "(F) Consequence of the indicated siRNAs and miR-517a on the viability of the indicated cell lines."
NCBI gene IDs:
"miR-517a: 574479"
Figure legend: "(G) Immunoblots indicate that miR-517a suppresses expression of ARCN1 in multiple miR-517a sensitive cell lines."
NCBI gene IDs:
"miR-517a: 574479"
Figure legend: "(A) Consequence of miR-124 on EOC cell viability (as in 2A). N, normal cell lines (IHH and HOSE). In the screen, miR-124 was found to significantly reduce cell viability (Z-score &lt; -2) in 6 cell lines, and TCGA expression data revealed no significant change in expression of this miRNA in ovarian tumors."
NCBI gene IDs:
"miR-124: RF00239"