EMBO/SourceData huggingface dataset:
Figure legend: "(A, B) WT BMDM were incubated for 1 h without (-) or with (+), the  IKKβ inhibitors BI605906 (5 μM), TPCA-1 (5 μM) or  PS1145  (10 μM), the TAK1 inhibitor NG25  (2 μM) or the  NLRP3  inhibitor  MCC950. The cells were then co-stimulated for 30 min without (-) or with (+) 100 ng/ml LPS and/or 4 mM ATP  (A) and/or 5 μM nigericin (B). The cell culture medium was removed and the cells lysed. Protein in the culture medium was  precipitated (see Methods), dissolved in  SDS. and subjected to SDS-PAGE, along with cell lysates. After transfer to PVDF membranes, immunoblotting was performed with antibodies recognizing both full length (FL) and cleaved (CL)  gasdermin D (GSDMD), the p20  and p10 fragments of caspase-1  and IL-18. Similar results were obtained in two independent experiments. (C) As in A, except that iBMDM from IKKβ-CXCR3-Cre (flox/flox) (IKKβ (fl/fl) and control WT cells were used. Similar results were obtained in three independent experiments. "
NCBI gene IDs:
"Cre: 2777477
CXCR3: 12766
IKKβ: 16150"
Figure legend: "(C, As in A, B except that iBMDM from  IKKβ-CXCR3-Cre (flox/flox) mice  (IKKβ (fl/fl)) were used. The U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) was used as a loading control. Similar results were obtained in two independent experiments."
NCBI gene IDs:
"Cre: 2777477
CXCR3: 12766
IKKβ: 16150"
Figure legend: "(E, F) As in A, B except that BMDM from caspase-1 KO mice were used. Similar results were obtained in two independent experiments."
NCBI gene IDs:
"caspase-1: 12362"
Figure legend: "(I-L) As in A-H, except that IKKβ  inhibitors were omitted and iBMDM from IKKβ-CXCR3-Cre (flox/flox) (IKKβ (fl/fl)) or WT mice  were co-stimulated for 1 h with 100 ng/ml LPS and 10 μM nigericin or left unstimulated (control). Scale bar = 50 μm."
NCBI gene IDs:
"Cre: 2777477
CXCR3: 12766
IKKβ: 16150"
Figure legend: "(I-L) As in A-H, except that iBMDM from IKKβ-CXCR3-Cre (flox/flox) (IKKβ  (fl/fl) or WT  mice  were co-stimulated for 1 h with 100 ng/ml LPS and 10 μM nigericin or left unstimulated. Similar results were obtained in two independent experiments. Data information: In all panels, scale bar = 50 μm. "
NCBI gene IDs:
"Cre: 2777477
CXCR3: 12766
IKKβ: 16150"
Figure legend: "(D) Absolute  cell numbers of the indicated cell types were determined by flow-cytometric analysis of the  bone marrow from 3-week-old Pax5+/+ and Pax5Jak2/+ mice. Average cell numbers are shown with SEM and were statistically analyzed by multiple t-tests (unpaired two-tailed with Holm-Šídák's correction); ns, not significant (P &gt; 0.05). One of 3 independent experiments is shown."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(F) Kaplan-Meier survival  analysis of  Pax5Jak2/+ (black) and control Pax5+/+ (grey) mice. n, number of mice analyzed. A P value of &lt; 0.0001 was determined for the   survival curves by statistical analysis with the log-rank (Mantel-Cox) test."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(H)  Eosin-hematoxylin-stained  sections of the lung and liver of a  Pax5Jak2/+ tumor mouse.  Infiltrating and blasting tumor cells  are indicated by an arrow."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(I)  Flow-cytometric  analysis of   lymph node cells from a control Pax5+/+ mouse and a 10-week-old Pax5Jak2/+ tumor mouse. (J) Flow-cytometric analysis of B220lowCD19+ B cells  from the bone marrow of a 4-week-old Pax5Jak2/+ mouse."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(D-G) GSEA analysis of 327 repressed (D) or 330 activated (F) Pax5  target genes identified in  pro-B cells as compared with the ranked log2-fold gene expression changes in  Pax5Jak2/+ (PJ)  B-ALLs versus control (Ctrl)  Pax5+/- Cdkn2ab+/- B-ALLs (left). NES, normalized enrichment score. The expression of five genes that are upregulated in  Pax5Jak2/+ B-ALL cells (upper row) and Pax5-/- (KO) pro-B cells (lower row) is shown in (E). Likewise, the  expression of five genes that are upregulated in control B-ALL cells (upper row) and Pax5+/+ (WT) pro-B cells  (lower row) is shown in (G). TPM, transcripts per million. Mean TPM values with SEM are shown for the following RNA-seq experiments: 3 (WT  pro-B), 2 (KO pro-B), 2 (Ctrl B-ALL), and 4 (PJ B-ALL)."
NCBI gene IDs:
"Cdkn2a: 12578
Jak2: 3717
Pax5: 18507"
Figure legend: "(H) Expression of the Ptprc  (CD45) gene from exon 3 to exon 8, as determined by  RNA-seq  of Pax5Jak2/+ and  Pax5+/- Cdkn2ab+/- B-ALL cells. The alternatively spliced exons 4 (A), 5 (B) and 6 (C) are indicated in orange in the respective exon-intron structure of the Ptprc  gene. Ptprc  transcripts of B220+ Pax5+/- Cdkn2ab+/- B-ALL cells contain all three exons, thus giving rise to expression of the CD45 isoform   RABC  (known as   B220). In contrast, reads at exon 4 are barely detectable and reads at exon 6 are strongly reduced in the mRNA of Pax5Jak2/+ B-ALL  cells, which likely gives rise to the  CD45 isoforms RBC and RB"
NCBI gene IDs:
"Cdkn2a: 12578
Jak2: 3717
Pax5: 18507
Ptprc: 19264
B220: 19264
CD45: 19265"
Figure legend: "(D) Flow-cytometric  analysis of bone marrow cells  from 4-week-old Pax5ihCd2/+ and  Pax5Jak2/ihCd2 mice. The  expression of  human (h) CD2  from the Pax5ihCd2 allele is shown for CD19+B220+ (grey) and  CD19+B220low (black) B cells."
NCBI gene IDs:
"Cd2: 914
Jak2: 3717
Pax5: 18507"
Figure legend: "(G) Kaplan-Meier survival  analysis of Cd79a-Cre Ikzf1neo/+ Pax5LSL-Jak2/+ (black) and Cd79a-Cre Pax5LSL-Jak2/+ (grey)  mice. Statistical analysis of the  survival  curves was performed with the log-rank (Mantel-Cox) test; ****P &lt; 0.0001. n, number of mice analyzed."
NCBI gene IDs:
"Cd79a: 12518
Cre: 2777477
Ikzf1: 22778
Jak2: 3717
Pax5: 18507"
Figure legend: "(H)  Flow-cytometric analysis of  B220 and CD19 expression  in  B-ALL  tumor cells from the  lymph node  of a Cd79a-Cre Ikzf1neo/+ Pax5LSL-Jak2/+ mouse (black; left). Pax5 expression  in these B-ALL  tumor cells (black line) and control  Pax5+/+ lymph node B cells (grey filled) was determined by intracellular  Pax5 staining (right)."
NCBI gene IDs:
"Cd79a: 12518
Cre: 2777477
Ikzf1: 22778
Jak2: 3717
Pax5: 18507"
Figure legend: "(B,  Flow-cytometric  analysis of bone marrow and spleen from  Pax5Jak2-KD/+ (black; n = 11) and control  Pax5+/+ (grey; n = 7)  mice  at the age of 6-8 weeks. The frequencies of the indicated B cell  types are shown for each organ (B). The data are presented as mean percentages with SEM and were statistically analyzed by multiple t-tests (unpaired and two-tailed with Holm-Šídák's correction); ns (P &gt; 0.5), *P &lt; 0.05, **P &lt; 0.01."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(B) Genome-wide  binding of Pax5-Jak2 in in vitro cultured pro-B cells from Pax5Jak2/+ Rosa26BirA/+ mice  at the age of 3 weeks (expressing  Pax5) and ex vivo Pax5Jak2/+ Rosa26BirA/+ B-ALL tumors (lacking Pax5), as determined by Bio-ChIP-seq analysis The DNA-binding  pattern of full-length  Pax5  was determined by  Bio-ChIP-seq  analysis of ex vivo sorted Pax5Bio/Bio pro-B cells, which carried a C‐terminal biotin acceptor sequence together with an  IRES‐BirA gene insertion in the 3' untranslated region of  Pax5  Two independent Bio-ChIP-seq experiments were performed for each cell type. Representative  binding patterns of Pax5 and Pax5-Jak2 in the three B cell  types are shown for a selected genomic region, with horizontal bars indicating Pax5  or Pax5-Jak2  peaks that were identified by MACS peak calling (left). The number of Pax5 (white) and  Pax5-Jak2  (grey or black) peaks, which were defined by stringent MACS peak calling with a P value of &lt; 10-10 in the three B cell types, are shown to the right."
NCBI gene IDs:
"BirA: 948469
Rosa26: 14910
Jak2: 3717
Pax5: 18507"
Figure legend: "(F, G) Flow-cytometric  analysis of the bone marrow and spleen  from  Pax5Prd*-Jak2 /+ (black; n = 6) and control Pax5+/+ (grey; n = 5)  mice at the age of 6-7 weeks. The frequency of the indicated B cell  types in each organ is indicated in (F), and the  flow-cytometric analysis of  CD19  and B220 expression on  bone marrow B cells  is shown in (G). Statistical data are shown as mean percentages with SEM and were analyzed by multiple t-tests (unpaired and two-tailed with Holm-Šídák's correction): ns &gt; 0.05; *P &lt; 0.05; **P &lt; 0.01. Each dot corresponds to one mouse."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(H) Kaplan-Meier survival  analysis of Pax5Prd*-Jak2 /+ (black) and  Pax5+/+ (grey) mice. A P value of &lt; 0.0001 was determined for the   survival  curves by statistical analysis with the log-rank (Mantel-Cox) test. n, number of  mice analyzed."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(D) Immunoblot analysis of whole-cell extracts prepared from Pax5Jak2/+ and control  Pax5Etv6/+ Cdkn2ab+/- B-ALL   cells as well as from the human HEL, TMD8 and  K1106 cell lines. Phosphorylated (p) STAT5 was detected with an anti-STAT5 (pY694) antibody and the pY41-peptide with the purified anti H3Y41ph antibody One to five pY41-peptides were coupled to  ubiquitin, which was added in the range of 50 ng per well. The Gapdh and histone H3 proteins were analyzed as loading control. An unspecific protein is denoted by an asterisk. One representative of 5 immunoblot experiments is shown."
NCBI gene IDs:
"Cdkn2a: 12578
Etv6: 14011
Jak2: 3717
Pax5: 18507"
Figure legend: "(A,  Tumor progression  in Il7+/+ (grey), Il7+/- (dashed) and  Il7-/- (black) mice transplanted with Pax5Jak2-Luc/+ tumor cells, as determined by bioluminescence  measurements at the indicated days after cell transfer. Images of three transplanted  mice for each Il7 genotype are shown at the indicated days after cell transfer"
NCBI gene IDs:
"Il7: 16196"
Figure legend: "(C)  Kaplan-Meier survival  analysis of Il7+/+,  Il7+/- and Il7-/- mice transplanted with Pax5Jak2-Luc/+ tumors cells. Statistical analysis of the  survival curves  was performed with the log-rank (Mantel-Cox) test; ns P &gt; 0.05, *P &lt; 0.05, **P &lt; 0.01."
NCBI gene IDs:
"Luc: 
Il7: 16196
Jak2: 3717
Pax5: 18507"
Figure legend: "(E) Quantification of the median fluorescence intensity (MFI) values of the p-STAT5 levels determined by intracellular staining  of splenic FO B cells from Pax5+/+ (grey), Pax5Jak2/+ (black) and  Pax5Jak2-KD/+ (white)  mice  at the age of 3-10 weeks Statistical data are presented as mean values with SEM and were analyzed by the two-tailed unpaired Student's t-test: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001. Each dot corresponds to one mouse."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(F) Flow cytometric analysis of p-STAT5  levels in pro-B cells (B220+CD19+Kit+IgM-) and leukemic B220low B cells  of Pax5Jak2/+ mice (black) as well as in control pro-B cells of Pax5+/+ (WT) mice (grey) at the age of 4-5 weeks. A representative  flow cytometric analysis of the bone marrow  of a Pax5Jak2/+ mouse (left) and representative intracellular p-STAT5 stainings  (middle) are shown. The p-STAT5 levels in  pro-B and  leukemic B220low B cells (right) are quantified as MFI values relative to that of  Pax5+/+ pro-B cells. Statistical data are presented as mean values with SEM and were analyzed by the two-tailed unpaired Student's t-test: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001. Each dot corresponds to one mouse."
NCBI gene IDs:
"Jak2: 3717
Pax5: 18507"
Figure legend: "(I) Upregulation of the genes Cxcr5, Syndig1l  and Sema4a in Pax5Jak2/+ (PJ) B-ALL cells. Mean TPM values with SEM are shown for the following RNA-seq  experiments: 2 (Ctrl B-ALL), 4 (PJ B-ALL)"
NCBI gene IDs:
"Cxcr5: 12145
Jak2: 3717
Pax5: 18507
Sema4a: 20351
Syndig1l: 627191"
Figure legend: "K) Identification of  Cxcr5, Syndig1l  and Sema4a as activated  STAT5 target genes. ChIP-seq  analysis identified STAT5-binding  regions at all three loci (K). Horizontal bars below the ChIP-seq track indicate STAT5-binding  regions identified by MACS peak calling. RPM, reads per million."
NCBI gene IDs:
"Cxcr5: 12145
Sema4a: 20351
Syndig1l: 627191"
Figure legend: "Western blots and quantification of RBM3 and GFP normalised to GAPDH in GFP-RBM3 i-neurons at 37°C or 32°C (72h)."
NCBI gene IDs:
"GFP: 
RBM3: 5935"
Figure legend: "(A-B) Median GFP intensity of BFP-positive GFP-RBM3 i-neurons measured by flow cytometry upon the sgRNA/Cas9-mediated KO of top 30 positive (A) or negative (B) regulator candidates. Statistical analysis is performed between the specific and non-targeting sgRNA groups for positive regulators (A) or between the specific sgRNA and reporter groups for negative regulators (B) within the 37°C or 32°C (72h) population."
NCBI gene IDs:
"Cas9: "
Figure legend: "(C) qRT-PCR of RBM3 mRNA level normalised to 18s rRNA in i-neurons at 37°C or 32°C (72h)."
NCBI gene IDs:
"18s rRNA: 
RBM3: 5935"
Figure legend: "RT-PCR of RBM3 mRNA (Exon 2-4) in i-neurons at 37°C or 32°C (72h) in the presence or absence of SMG1 inhibitor. PSI values of RBM3 PE are calculated based on the intensity of PE-included (red arrows) and PE-skipped (green arrow) isoforms."
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "qRT-PCR using a combination of primers targeting Exon 3a, Exon 3 or Exon 4-5 quantifies the PSI values of RBM3 PE (Exon 3a, including both 3a-L and 3a-S) relative to Exon 3 or Exon 4-5 at 37°C or 32°C (72h) in the presence or absence of SMG1 inhibitor."
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "RT-PCR of RBM3 mRNA (Exon 2-4) in HeLa cells at 37°C and 32°C (48h) in the presence or absence of SMG1 inhibitor. PSI values of RBM3 PE are depicted in the graph on the right."
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "Schematics and RT-PCR of RBM3 minigene (Exon 1-4), flanked by unique sequences (thick black bars) to distinguish it from endogenous transcripts during PCR amplification, expressed in HeLa cells at 37°C or 32°C (48h), in the presence or absence of SMG1 inhibitor. PSI values of RBM3 PE are depicted in the graph on the right."
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "(A-B) qRT-PCR quantifying the PSI values of RBM3 PE relative to RBM3 mRNA in WT i-neurons at 37°C (A) or 32°C (72h) (B), when NMD is blocked by SMG1 inhibitor. Statistical analysis is performed between the specific and non-targeting sgRNA groups. "
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "PSI values of RBM3 Exon 3a-L in control and HNRNPH1-knocked down K562 and HepG2 cells. RNA-Seq data from ENCODE Project, 2 isogenic replicates are included."
NCBI gene IDs:
"HNRNPH1: 3187
RBM3: 5935"
Figure legend: "(D-E) RT-PCR of endogenous RBM3 (D) and expressed RBM3 minigene (E) in control (scramble siRNA) or HNRNPH1-knocked down HeLa cells at 37°C or 32°C (48h), in the presence or absence of SMG1 inhibitor. The ratio of PSI values between HNRNPH1 KD and control is shown for only the SMG1 i-treated conditions."
NCBI gene IDs:
"HNRNPH1: 3187
RBM3: 5935"
Figure legend: "(F-G) RT-PCR of endogenous RBM3 (F) and expressed RBM3 minigene (G) in SMG1 inhibitor-treated control (untransfected) or FLAG-HNRNPH1-overexpressing (OX) HEK293T cells at 37°C. PSI values of RBM3 PE are shown in the graphs on the right respectively. "
NCBI gene IDs:
"FLAG: 
HNRNPH1: 3187
RBM3: 5935"
Figure legend: "WT i-neurons are transduced with lentiviral constructs expressing BFP (Control) or HNRNPH1-T2A-BFP (HNRNPH1 overexpression, OX) at 37°C and 32°C, followed by RT-PCR of endogenous RBM3 with 24h SMG1 inhibitor treatment. PSI values of RBM3 PE are shown in the graph on the right."
NCBI gene IDs:
"BFP: 
HNRNPH1: 3187
RBM3: 5935"
Figure legend: "RT-PCR of WT and delGGGG RBM3 minigenes in HeLa cells at 37°C or 32°C (48h) treated with SMG1 inhibitor. PSI values of RBM3 PE are shown in the graphs on the right."
NCBI gene IDs:
"RBM3: 5935"
Figure legend: "BrdU incorporation reflecting DNA synthesis and SA-b-gal activity as markers of CTX-induced senescence in Em-myc transgeniccontrol;Bcl2 versus Suv39h12;Bcl2lymphomas in vivo. Numbers represent mean percentages of positive cells6s.d. (n55 each)."
NCBI gene IDs:
"Bcl2: 12043
Suv39h1: 20937"
Figure legend: "b, Representative whole-body FLT- and FDG-PET scans of an individual control;Bcl2 lymphoma-bearing mouse at tumour manifestation (untreated) and at day 6 after a single dose of CTX. Red circles, areas of specific tracer retention; green circles, matching areas with lost retentions. Specific tracer uptake was assessed by calculation of tumour-to-background ratios. Data represent mean ratios ± s.d. (n = 5 mice for FLT-PET scans and n = 6 mice for FDG-PET scans). Insets show representative Ki67 staining and colour-calibrated (red, highest intensities; blue, lowest intensities) bioluminescence images of glucose levels in tissue sections of the respective groups."
NCBI gene IDs:
"Bcl2: 12043"
Figure legend: "c, Intracellular glucose concentrations in untreated and ADR-treated control;Bcl2 (that is, senescent) versus Suv39h1-;Bcl2 (that is, non-senescent) lymphomas in vitro (as in d-g). Results represent means ± s.d. (n = 5 each)."
NCBI gene IDs:
"Bcl2: 12043
Suv39h1: 20937"
Figure legend: "d, Extracellular levels of the specified metabolite-to-glucose ratios in the indicated lymphoma cells groups relative to untreated control;Bcl2 lymphoma cells after 18 h of cultivation. Data represent mean ratios ± s.d. (n = 4 each, measurements were carried out in duplicate). Note that glucose-6-phosphate is not detectable (n.d.) in the medium. Insets show (ADR-treated relative to untreated) intracellular levels of the respective metabolites after labelling with 13C6-glucose for one representative lymphoma from each group. Data represent mean ratios (see Supplementary Fig. 5 for an assessment of the heterogeneity of the TIS-associated hypermetabolism and a comparison of the metabolic parameters of individual lymphomas)."
NCBI gene IDs:
"Bcl2: 12043"
Figure legend: "e, Immunoblot analyses of phosphorylated AMP-activated protein kinase (pAMPK), total AMPK, pyruvate kinase isoforms M1 and M2 in ADR-senescent control;Bcl2 versus ADR-treated Suv39h1-;Bcl2 lymphoma cells in vitro (n = 3 each; α-tubulin as a loading control. Gels were cropped to ease presentation; full-length blots are provided in Supplementary Fig. 16)."
NCBI gene IDs:
"Bcl2: 12043
Suv39h1: 20937"
Figure legend: "f, Mean OCRs in ADR-senescent control;Bcl2 versus ADR-treated Suv39h1−;Bcl2 lymphoma cells in vitro. Results represent means ± s.d. (n = 5 each)."
NCBI gene IDs:
"Bcl2: 12043
Suv39h1: 20937"
Figure legend: "a-e, Cell viability by trypan blue dye exclusion in ADR-senescent control;Bcl2 versus ADR-treated Suv39h1-;Bcl2 lymphoma cells at day 5 compared to the untreated condition in various biochemical, pharmacological or genetic interventional settings in vitro. All results in this figure represent means ± s.d. (n = 5 each). a, Inhibition of glucose metabolism by phloretin, cytochalasin B, and sodium oxamate."
NCBI gene IDs:
"Bcl2: 12043
Suv39h1: 20937"
Figure legend: "c, Lentiviral knockdown of hexokinase 2 (Hk2) by short hairpin RNA (shHk2). d, Inhibition of AMPK by compound C. e, Block of fatty acid oxidation by the carnitine palmitoyltransferase I inhibitor etomoxir. f, Inhibition of the electron transport chain by antimycin A. *P  0.01, except b (n = 8 each) and e, in which *P  0.05."
NCBI gene IDs:
"hexokinase 2: 15277"
Figure legend: "Proteostasis analysis in TIS control versus senescence-incapable lymphoma cells in vitro, as in Fig. 2, or versus SASP-attenuated TISlymphoma cells. a, Global protein synthesis rate, measured by incorporation of green-fluorescent methionine. Mean fluorescent intensities reflect newly synthesized protein within 2 h (DAPI used as a counterstain). Data represent means ± s.d. (n = 5 each). b, Rate of global protein synthesis (measured as in a) in ADR-senescent relative to untreated (ut) control;Bcl2 lymphoma cells; either empty vector-infected cells or cells stably expressing the NF-kB super-repressor IkBaDN(SR, ref. 18). Results represent means ± s.d. (n = 5 each). c, Relative intracellular glucose concentrations in cells as in b."
NCBI gene IDs:
"Bcl2: 12043
IkBaDN: 18035"
Figure legend: "f, Expression of the transcription factors Xbp1 (by RT-PCR (PCR with reverse transcription; top); note that the lower band reflects the UPR-related splice form), ATF4, CHOP, phospho-Jun N-terminal kinase (JNK-P-Thr183/Thr185) and total JNK(by immunoblot analysis, with a-tubulin as a loading control; bottom) in lymphoma cells as indicated (n = 3 each, gels were cropped to ease presentation; full-length blots are provided in Supplementary Fig. 16)."
NCBI gene IDs:
"Xbp1: 22433"
Figure legend: "a, Cellular viability of super-repressor- or empty-vector-infected control;Bcl2 lymphomas treated with ADR or untreated for 5 days, then exposed for 2 days to the inhibitors 2DG or bafilomycin A1, compared to no inhibitor (ut) in vitro. Results represent means ± s.d. (n = 5 each)."
NCBI gene IDs:
"Bcl2: 12043"
Figure legend: "b, Immunoblot analyses of ATF4, global protein ubiquitination, p62/SQSTM1, and MAP1-LC3-I to MAP1-LC3-II conversion in control;Bcl2 lymphomas with no ADR treatment, in TIS cells, and in TIS cells after exposure to 2DG or bafilomycin A1in vitro; representative blot with α-tubulin as a loading control (gels were cropped to ease presentation; full-length blots are provided in Supplementary Fig. 16). c, Cleavage (activation) of caspase 12 and detection of cleaved caspase 3 by immunoblot analysis of control;Bcl2 lymphomas as in b; representative blot with α-tubulin as a loading control (gels were cropped to ease presentation; full-length blots are provided in Supplementary Fig. 16)."
NCBI gene IDs:
"Bcl2: 12043"
Figure legend: "d, Cellular viability of ADR-treated control;Bcl2 lymphoma cells infected with short-hairpin RNAs against either caspase 12 (shCasp12) or caspase 3 (shCasp3) compared to empty vector-infected lymphoma cells treated as in a. Results represent means ± s.d. (n = 4 each)."
NCBI gene IDs:
"Bcl2: 12043
caspase 12: 12364
caspase 3: 12367"
Figure legend: "h, Colour-coded whole-body fluorescence imaging to visualize green fluorescent protein (GFP)-tagged tumour burden in time-courses of three representative mice harbouring CTX-senescent control;Bcl2 lymphomas at day 5 (see Figure 1a), and two days later, after the administration of 2DG (n = 3 mice), bafilomycin A1 (n = 4 mice) or mock treatment (n = 4 mice) starting from day 5 post CTX (red, highest intensities; blue, lowest intensities). TdT-mediated dUTP nick end labelling (assay) (TUNEL) staining of lymph node sections in situ to visualize apoptosis at day 7. Numbers represent means ± s.d. (n = 3)."
NCBI gene IDs:
"Bcl2: 12043"
Figure legend: "i, Overall survival of 5 day-CTX-treated control;Bcl2 or Suv-39h1-;Bcl2 lymphoma-bearing mice randomly assigned to sequential exposure to bafilomycin A1 or mock as in h (control;Bcl2: n = 12 and Suv39h1-;Bcl2: n = 10), presented as matched pair analyses (P&lt;0.001 for the control; Bcl2 comparison; P = 0.221 for the Suv39h1-;Bcl2 comparison). *P&lt;0.05."
NCBI gene IDs:
"Bcl2: 12043
Suv-39h1: 20937
Suv39h1: 20937"
Figure legend: "g, Expression of CPAP-GFP or CPAP-CC5-GFP in Seckel NPCs slightly increases nestin-positive cells (i), decreases neuronal differentiation (for CC5 *p&lt;0.05) (ii), decreases ciliary length (for CPAP ***p&lt;0.001 and for CC5 **p&lt;0.01) (iii), elevates mitotic index (for CC5 *p&lt;0.05) (iv) and decreases the number of ciliated cells (for CPAP *p&lt;0.05 and for CC5 **p&lt;0.01) (v) compared to control (mock electroporation). Error bars show s. e. m. One-way ANOVA followed by Tukey's multiple comparisons test. n = 3 independent experiments with &gt;350 (nestinstaining, differentiation and mitotic index), and &gt;70 cells (cilium length) cells."
NCBI gene IDs:
"CPAP: 55835"