EMBO/SourceData huggingface dataset:
Figure legend: "Quantification of lymphatic vessel density (B) in Peyer's Patches in Casp8WT and Casp8ECko mice  at an early disease stage (n = 9 WT, 7-10 ECko  Peyer's Patches  are pooled from 4-6 mice  per genotype; one-way ANOVA with tukey's multiple comparison). Data information: Data shown as mean ± SEM. * P &lt;0.05, ** P &lt;0.01, *** P &lt;0.001, **** P &lt;0.0001, ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "representative pictures of CD31  (pan EC) and  Lyve1 (lymphatic) staining (C) in Peyer's Patches  in Casp8WT and Casp8ECko mice  at an early disease stage (n = 9 WT, 7-10  ECko Peyer's Patches are pooled from 4-6 mice  per genotype Scale bars: 200µm."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "D-F. Representative images (D) and quantifications (E, F) of stainings   for CD31, Lyve1  and DAPI (nuclei) in  small intestinal wholemounts at an early disease stage (blue arrowheads point to defective lacteals, white arrowheads indicate edema) in Casp8ECko mice  (E; n= 7 WT, 6 ECko. F; n= 7 WT, 10 ECko; two tailed unpaired Student's t-test). Scale bars: 100µm. Data information: Data shown as mean ± SEM. * P &lt;0.05, ** P &lt;0.01, *** P &lt;0.001, **** P &lt;0.0001, ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "G. Representative images of small intestine  sections of mice  injected with a 70kDa fluorescently labeled dextran  and stained  for CD31  at an early disease stage. White arrowheads point to extravasated dextran  in Casp8ECko mice  (n= 5 WT, 5 ECko). Scale bars: 50µm. H. Quantification of extravasated dextran  in small intestine  and brain  lysates in Casp8WT and  Casp8ECko mice  at an early disease stage (n= 4 WT, 4-5 ECko; two-way ANOVA with tukey's multiple comparison). RFU: relative fluorescent units. Data information: Data shown as mean ± SEM. * P &lt;0.05, ** P &lt;0.01, *** P &lt;0.001, **** P &lt;0.0001, ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "I. Representative images of CD31  and VE-Cadherin staining  in intestinal  wholemounts at an early disease stage (n= 5 WT, 5 ECko) in  Casp8WT and  Casp8ECko mice  (red arrowheads point to  VE-Cadherin  'empty' vessel patches). Scale bars: 25µm."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "A-B. Representative images (A) and quantification (B) of CD31, TUNEL and DAPI staining in small intestine sections of Casp8WT and Casp8ECko mice  at an early disease stage (red dotted lines: epithelium; white dotted lines: endothelium) in (n= 5 WT, 5  ECko, multiple t-tests with Holm-Sidak method). Scale bars: 100µm. Data information: All data is shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "D-E. Graphs showing survival  and relative weight  of Casp8WT/MLKLko and  Casp8ECko/MLKLko mice  upon tamoxifen  treatment. (D; n= 5-8 WT/ MLKLko, 5-8 ECko/MLKLko; Log-Rank test, E; n= 7 WT, 8  ECko; two tailed unpaired Student's t-test)."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "F. Representative pictures of intestines  of Casp8WT/MLKLko and Casp8ECko/MLKLko mice  at 30 days after tamoxifen  treatment (n= 8 WT, 8 ECko)."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "G. Representative images of stainings  for CD31, Lyve1  and DAPI  in  small intestinal wholemounts from Casp8WT/MLKLko and Casp8ECko/MLKLko mice  at 30 days after tamoxifen  treatment. Scale bars: 100µm."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "H-K. Quantification of vessel area (H, I) and lacteal  length (J, K) at two different timepoints  after tamoxifen  treatment in Casp8WT/MLKLko and Casp8ECko/MLKLko mice  (n= 4-6 WT/MLKLko, 5  ECko/MLKLko; two tailed unpaired Student's t-test). Data information: All data is shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "L. Graph showing quantification of extravasated  70kDa Dextran  from small intestine  tissue of Casp8WT/MLKLko and Casp8ECko/MLKLko mice  at 30 days after tamoxifen  treatment (n= 7 WT/MLKLko, 6 ECko/MLKLko; two tailed unpaired Student's t-test). Data information: All data is shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "M-N. Representative pictures (M) and quantification (N) of lymphatic vessel density in  Peyer's Patches of  Casp8WT/MLKLko and Casp8ECko/MLKLko mice  at 140 days after tamoxifen  treatment (n = 8 WT, 7 ECko Peyer's Patches are pooled from 4 mice  per genotype; two-tailed unpaired students t-test). Scale bars: 200µm. Data information: All data is shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "O. Representative pictures of H&amp;E stainings  of  small intestine  tissue of Casp8WT/MLKLko and Casp8ECko/MLKLko mice  (n= 4-6 WT, 4-5  ECko). Scale bars: 100µm. P-Q. Quantification of intestinal pathology  in Casp8WT/MLKLko and Casp8ECko/MLKLko mice  at two different timepoints  after tamoxifen  treatment (enteropathy score; n=4-6 WT/MLKLko, 5 ECko/MLKLko; two tailed unpaired Student's t-test). Data information: All data is shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "A. Representative pictures of TUNEL staining together with CD31  and  Lyve-1  in  Peyer's Patches  of Casp8WT and Casp8ECko mice. TUNEL+ LECs, but not  BECs could already be seen in non-hemorrhagic Peyer's Patches  (a'), and further accumulated in hemorrhagic Peyer's Patches (a''). White dotted areas outline location of the lymphatic plexus. White arrowheads point to TUNEL+ LECs  (note that necroptotic LECs only weakly express Lyve-1). Scale bars: 50µm, insets: 10µm."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "C. Survival (n= 5 WT, 6 BECko; Log-Rank test) of Casp8WT and Casp8ECko mice  upon tamoxifen  treatment."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "D. Representative pictures of intestines  of Casp8WT and Casp8BECko mice."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "Representative pictures of H&amp;E staining of small intestine  of Casp8WT and Casp8BECko mice (E),  enteropathy score (F; n= 5 WT, 6 ECko, two tailed unpaired Student's t-test) Scale bars: 100µm, insets: 50µm. Data information: Data shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "Representative images of stainings  for CD31, Lyve1  and DAPI  in small intestinal  wholemounts (H) and quantification of vessel density (I) in  Casp8BECko compared to Casp8WT mice (I; n= 5 WT, 6 BECko; two tailed unpaired Student's t-test, Scale bars: 100µm. Data information: Data shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "quantification of lacteal  length (J) in  Casp8BECko compared to Casp8WT mice  ; n= 5 WT, 5 BECko; two tailed unpaired Student's t-test with Welch's correction). Data information: Data shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "K-L. Representative pictures (K) and quantification (L) of lymphatic vessel density  Peyer's Patches in  Casp8WT and Casp8BECko mice  (n = 10 WT, 11 BECko Peyer's Patches  from 5-6 mice per genotype; two tailed unpaired Student's t-test). Scale bars: 200µm. Data information: Data shown as mean ± SEM. ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "B. Survival  graph after intravenous TNF-α injection of Casp8WT vs. Casp8ECko mice  within the first 24h (n=11 WT, 11 ECko; Log-Rank test)."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "C. Representative images of the small intestines 24h after  TNF-α injection in Casp8WT and Casp8ECko mice  (blue arrowheads point to Peyer's Patches)."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "D-E. Representative pictures of Peyer's Patches (D) and quantification of lymphatic vessel density (E) in Casp8WT, Casp8ECko and Casp8ECko/MLKLko mice  injected with TNF-α (n=7 WT, 5 ECko, 15 ECko/MLKLko. Peyer's Patches  are pooled from 3-5 mice  per genotype). Scale bars: 200µm. Data information: All data is shown as mean ± SEM. * P&lt;0.05, *** P &lt;0.001, **** P &lt;0.0001; ns: not significant."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "F. Representative pictures of TUNEL staining  together with CD31  and Lyve-1 in  Peyer's Patches of Casp8WT, Casp8ECko and Casp8ECko/MLKLko mice injected with TNF-α. TUNEL+ LECs, but not BECs  could already be seen in Casp8ECko, but neither in Casp8WT nor in Casp8ECko/MLKLko mice. White dotted areas outline location of the lymphatic plexus. Yellow arrowheads point to TUNEL+ECs). Scale bars: 50µm."
NCBI gene IDs:
"Casp8: 12370
MLKL: 74568"
Figure legend: "H. Survival  graph of Casp8WT and Casp8ECko mice  after Enbrel® treatment (n=7 WT, 5  ECko +  IgG, 8 ECko + Enbrel; Log-Rank test)."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "Representative images of small intestines (I) of  Casp8ECko mice  after Enbrel® treatment Scale bars: 100µm."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "Representative images of H&amp;E staining  (J) with histopathological scoring (K) of Casp8WT and Casp8ECko mice   after Enbrel® treatment (n=6 WT, 4 ECko +  IgG; 8  ECko + Enbrel (from which 3 mice  were diseased, 5 mice  healthy); one-way ANOVA with tukey's multiple comparison). Scale bars: 100µm. Data information: All data is shown as mean ± SEM. * P&lt;0.05, *** P &lt;0.001, **** P &lt;0.0001; ns: not significant."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "analysis of the most prominent bacterial phyla (B; n= 4 Control, 6-8 Antibiotics; multiple t-tests with Holm-Sidak method) by qPCR analysis, In B, the cycle number of 16S rDNA expression  compared to the total number of cycles is shown. Data information: Data shown as mean ± SEM. ** P &lt;0.01, *** P &lt;0.001, **** P &lt;0.0001; ns: not significant. Scale bars: 100μm."
NCBI gene IDs:
"16S rDNA: "
Figure legend: "E. Representative images of the gut  of  Casp8WT and Casp8ECko mice  with antibiotic  treatment 30 days after tamoxifen."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "F-H. Representative images of H&amp;E staining  (F), quantification of intestinal pathology  (G) and mucosal hemorrhages  (H) in  Casp8WT and Casp8ECko mice treated with antibiotics  compared to untreated Casp8ECko mice (G; n= 6 WT, 4 ECko+ antibiotics, 5  ECko; one-way ANOVA with tukey's multiple comparison, H; n= 6 WT, 4 ECko+ antibiotics, 4 ECko; one-way ANOVA with tukey's multiple comparison). Data information: Data shown as mean ± SEM. ** P &lt;0.01, *** P &lt;0.001, **** P &lt;0.0001; ns: not significant. Scale bars: 100μm."
NCBI gene IDs:
"Casp8: 12370"
Figure legend: "A summary bar graph showing the quantitative real-time PCR data for TMEM16A, TMEM16B, and BEST1 with cDNA samples prepared from the mHb and hippocampus of adult mouse brains (N=3, n=3 each, unpaired Student t-test, data are presented as mean values ± s.e.m.)."
NCBI gene IDs:
"TMEM16A: 101772
TMEM16B: 243634
BEST1: 24115"
Figure legend: "RNAscope ISH showed an apparent expression of TMEM16A mRNA co-localized with ChAT and Tac1 signals in the mHb compared to the ones in lHb. Enlarged images showed that signals of TMEM16A and Tac1 in the dorsal mHb or ChAT in the ventral mHb reside together at the single cell level."
NCBI gene IDs:
"TMEM16A: 101772
ChAT: 12647
Tac1: 21333"
Figure legend: "Immunohistochemical staining of 40-µm coronal brain sections with an anti-TMEM16A antibody. The TMEM16A signals in the mHb of TMEM16A cKO mice were compared to the ones of littermate controls. TMEM16A colocalized with the cholinergic marker ChAT in the mHb. The specific deletion of TMEM16A in the mHb is evident."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Representative traces demonstrating the spontaneous activity of the mHb neurons in a cell-attached mode from TMEM16A cKO mice compared to the one from littermate controls. D. A summary bar graph showing the frequencies of spontaneous firing of the mHb neurons in TMEM16A cKO (4 mice) and littermate controls (The numbers inside each bar indicate the numbers of recorded cells from 4 mice each, paired Student t-test, data are presented as mean values ± s.e.m.)."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Representative averaged traces of sAPs of the mHb neurons with the pipette solution (40 mM Cl- and 0.5 mM EGTA) from TMEM16A cKO mice and littermate controls."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Summary bar graphs showing the frequency, half-width, and AHP slope of the sAPs of mHb neurons from TMEM16A cKO mice and littermate controls (The numbers inside each bar indicate the numbers of recorded cells, unpaired Student t-test, data are presented as mean values ± s.e.m.)."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Immunohistochemical images of the IPN region from control and TMEM16A cKO mice. The c-Fos signal was greatly reduced in TMEM16A cKO mice. Scale bar = 200 μm."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "A summary bar graph showing reduced c-Fos expression in the IPN in TMEM16A cKO mice. (NCTL=7 (n=42), NcKO=6 (n=36), unpaired Student t-test, data are presented as mean values ± s.e.m.)."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Representative traces of sEPSCs of neurons in the medial part of the IPN showing a reduced frequency in TMEM16A cKO mice compared to that of littermate controls."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Summary bar graphs of the frequency and amplitude of the sEPSCs of IPN neurons in TMEM16A cKO (cKO) mice and littermate controls (CTL). Data are presented as mean values ± s.e.m. (paired Student t-test). The numbers inside each bar indicate the numbers of recorded cells."
NCBI gene IDs:
"TMEM16A: 101772"
Figure legend: "Representative traces showing that the spontaneous firing of mHb neurons from ChAT(+)-cre::hM4D(Gi) mice were reduced when CNO (10 μM) was applied in the ACSF."
NCBI gene IDs:
"hM4: 1132
cre: 2777477"
Figure legend: "A summary bar graph showing the reduction of normalized frequencies of spontaneous firing of the mHb neurons transfected with AAV-hM4Di-mCherry before and during CNO treatment (The numbers inside each bar indicate the numbers of recorded cells)."
NCBI gene IDs:
"mCherry: 
hM4: 1132"
Figure legend: "In the EPM task, the time spent in the open arms of CNO-treated ChAT(+)-cre::hM4D(Gi) mice was significantly decreased compared to that of the PBS-treated controls (CTL). (nCTL=6, ncKO=9, unpaired Student t-test). E. In the LDB task, the time spent in the light zone by CNO-treated ChAT(+)-cre::hM4D(Gi) mice was significantly decreased compared to that spent by the PBS-treated control mice. (nCTL=6, ncKO=9, unpaired Student t-test). F. In the PA task, the entry latency of CNO-treated mice was significantly decreased compared to that of the CTL group. (nCTL=6, ncKO=9, unpaired Student t-test). G. Nestlet shredding behaviors of the CNO-treated ChAT(+)-cre::hM4D(Gi) mice were also decreased. (nCTL=6, ncKO=9, unpaired Student t-test;)."
NCBI gene IDs:
"ChAT: 12647
hM4: 1132
cre: 2777477"
Figure legend: "In the 3-chamber test, the subject mouse of the PBS-treated mice and the CNO-treated mice explored freely the three test chambers. The time spent in each chamber during two sessions was measured. The CNO-treated ChAT(+)-cre::hM4D(Gi) mice exhibited a decreased interest for a stranger mouse (S1) against objects (O) compared to the PBS-treated group (left two panels) (nCTL=6, ncKO=9, unpaired Student t-test). I. When CNO-treated ChAT(+)-cre::hM4D(Gi) mice were exposed to a new stranger mouse (S2) against the familiar S1 mouse, they also showed a decreased interest for the S2 mouse compared to the PBS-treated control group (right two panels). The preference index showed decreased sociability of the CNO-treated group in both sessions (nCTL=6, ncKO=9, unpaired Student t-test;)."
NCBI gene IDs:
"ChAT: 12647
hM4: 1132
cre: 2777477"
Figure legend: "MCF7, MCF7/ADR and MCF7/IR, MDA-MB-231 and MDA-MB-231/ADR cells were harvested and mRNA levels of BRD7 were determined by real-time PCR (n=3). Values are mean ± SEM and Error bars indicate SEM."
NCBI gene IDs:
"BRD7: 29117"
Figure legend: "Silver staining of the BRD7 complex separated by SDS-PAGE. HEK293T cells stably expressing SFB-tagged BRD7 were used for tandem affinity purification (TAP) of protein complexes. BRD7-interacting proteins, including PARP1 and PIK3R2, are indicated."
NCBI gene IDs:
"BRD7: 29117"
Figure legend: "HEK293T cells transiently transfected with Flag-PARP1 and Myc-BRD7 for 24 h were lysed with RIPA buffer. Followed by immunoprecipitation (IP) using antibodies to Myc (C) conjugated to agarose followed by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"Flag: 
Myc: 
BRD7: 29117
PARP1: 142"
Figure legend: "HEK293T cells transiently transfected with Flag-PARP1 and Myc-BRD7 for 24 h were lysed with RIPA buffer. Followed by immunoprecipitation (IP) using antibodies to Flag (D) conjugated to agarose followed by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"Flag: 
Myc: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa and 293T cells transfected with Myc-BRD7 plasmid for 24 h were lysed with RIPA buffer. Lysates were then immunoprecipitated using anti-Myc agarose and immunoblotted using the indicated antibodies. Ribosylation levels of exogenous BRD7 were detected using anti-PAR antibody (n=3)."
NCBI gene IDs:
"Myc: 
BRD7: 29117"
Figure legend: "HeLa cells transfected with Myc-BRD7 plasmid. After 24 hours, cells were treated with either CPT (1 μM) or ADR (5 μM) combined with MG132 (10 μM) for indicated times. Cellular lysates were immunoprecipitated using anti-Myc agarose and immunoblotted using the indicated antibodies (n=3)."
NCBI gene IDs:
"Myc: 
BRD7: 29117"
Figure legend: "HeLa PARP1 wild-type and PARP1 knockout cells were transfected with Myc-BRD7 for 24 h, lysates were subjected to immunoprecipitation using anti-Myc agarose and analysed by Western blot (n=3)."
NCBI gene IDs:
"Myc: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa were transfected with BRD7 wild-type and various BRD7 mutant plasmids for 24 h, lysed with RIPA, followed by anti-Myc IP and Western blot with indicated antibody (n=3)."
NCBI gene IDs:
"BRD7: 29117"
Figure legend: "HeLa cells were transfected with Flag-PARP1 and Myc-BRD7 for 24 h, then treated with MG132 (10 μM) for additional 4 h, and proteins were detected by Western blot with indicated antibodies (n=3)."
NCBI gene IDs:
"Flag: 
Myc: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa cells were transfected with either scrambled or PARP1 siRNAs for 48 h, protein levels were detected by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"PARP1: 142"
Figure legend: "Expression of BRD7, p21 and PARP1 measured in PARP1 wild-type and knockout HeLa cells using PARP1 sgRNA by Western blot (n=3)."
NCBI gene IDs:
"PARP1: 142"
Figure legend: "Wild-type and PARP1 knockout HeLa cells were incubated with 10 μg/ml cycloheximide (CHX) for the indicated times. Lysates were harvested and analysed by Western blot. Quantification of BRD7 protein are shown in F (n=3) and results represent mean ± SEM. Error bars indicate SEM. Relative amounts normalized to the BRD7 protein level at 0 h of Control or sgPARP1 cells, respectively."
NCBI gene IDs:
"PARP1: 142"
Figure legend: "PARP1 wild-type and knockout HeLa cells were transfected with HA-ubiquitin for 24 h, and MG132 (10 μM) was added for an additional 4 h, cells were lysed with RIPA buffer; followed by anti-BRD7 IP and analysed by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"HA: 
PARP1: 142"
Figure legend: "SFB-BRD7 stably overexpressing HeLa cells transfected with scramble or PARP1 siRNA for 24 h were transfected with vector or HA-ubiquitin (Lys48 or Lys63 only) for 24 h, and MG132 (10 μM) was added for an additional 4 h, lysed with RIPA, subjected to IP using S tag beads followed by Western blot (n=3)."
NCBI gene IDs:
"HA: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa cells were co-transfected either wild-type or BRD7 mutant with Flag-PARP1 for 24 h and analysed by Western blot (n=3)."
NCBI gene IDs:
"Flag: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa cells were co-transfected with either wild-type or BRD7 mutant plus HA-ubiquitin for 24 h, and MG132 (10 μM) was added for an additional 4 h and lysed with RIPA buffer, followed by anti-Myc agarose IP and analysed by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"HA: 
BRD7: 29117"
Figure legend: "HeLa and MDA-MB-231 cells were transfected with either scrambled or RNF146 siRNAs (48 h). Protein levels were detected by Western blot. PTEN, which is a known RNF146-interacting protein, was included as a positive control (n=3)."
NCBI gene IDs:
"RNF146: 81847"
Figure legend: "HeLa cells were transfected with either scrambled or RNF146 siRNAs for 48 h, followed by incubation with 10 μg/ml cycloheximide (CHX) for the indicated periods of time. Lysates were harvested and analysed by Western blot (n=3). Quantification of BRD7 protein levels from B, n=3. Error bars indicate SEM. Relative amounts normalized to the BRD7 protein level at 0 h."
NCBI gene IDs:
"RNF146: 81847"
Figure legend: "Control and RNF146 stably overexpressing HeLa cells were transfected with Myc-BRD7-WT for 24 h, followed by incubation with 10 μg/ml cycloheximide (CHX) for indicated periods of time. Lysates were subjected to Western blot analysis (n=3). Quantification of BRD7 protein levels from D, n=3. Error bars indicate SEM. Relative amounts normalized to the BRD7 protein level at 0 h."
NCBI gene IDs:
"Myc: 
BRD7: 29117
RNF146: 81847"
Figure legend: "HeLa cells transfected with either RNF146 or control siRNA for 24 h followed by transfection of HA-ubiquitin for another 24 h; MG132 (10 μM) was added for 4 h and lysed with RIPA, followed by anti-BRD7 IP and analysed by Western blot with the indicated antibodies (n=3)."
NCBI gene IDs:
"HA: 
RNF146: 81847"
Figure legend: "HeLa cells stably expressing RNF146 were transfected with HA-ubiquitin for 24 h; MG132 (10 μM) was added for an additional 4 h, followed by anti-BRD7 IP and Western blot (n=3)."
NCBI gene IDs:
"HA: 
RNF146: 81847"
Figure legend: "HeLa cells with wild-type or PARP1 knockout were transfected with Myc-BRD7-WT for 24 h, their lysates were subjected to IP using anti-Myc agarose and analysed by Western blot with indicated antibodies (n=3)."
NCBI gene IDs:
"Myc: 
BRD7: 29117
PARP1: 142"
Figure legend: "HeLa cells stably expressing Flag-RNF146 were transfected with either Myc-BRD7-WT or Myc-BRD7-mutant for 24 h, lysates were subjected to IP using anti-Flag agarose and analysed by Western blot with indicated antibodies (n=3)."
NCBI gene IDs:
"Flag: 
Myc: 
BRD7: 29117
RNF146: 81847"
Figure legend: "MDA-MB-231 cells were transfected twice with BRD7 siRNAs, and these cells were subjected to CCK8 assay after treatment with Olaparib (10 μM) combined with either ADR (0.5 μM) or VP16 (10 μM) for 72 h (n=3). Results represent mean ± SEM of three experiments and Error bars indicate SEM. N.S., not significant; **P &lt; 0.01, Student's t test."
NCBI gene IDs:
"BRD7: 29117"
Figure legend: "Resistance of BRD7-depleted cells to Olaparib was reversed by the expression of wild-type BRD7 but not mutant BRD7. shRNA-resistant BRD7 wild-type and BRD7 mutant plasmids were transduced into BRD7-depleted MDA-MB-231 cells, and cell viability was determined as indicated above (n=3). Results represent mean ± SEM of three experiments and Error bars indicate SEM. N.S., not significant; **P &lt; 0.01, Student's t test."
NCBI gene IDs:
"BRD7: 29117"
Figure legend: "A -C. Drug-resistant ABL1-T315I rescues dasatinib- and imatinib-induced cytotoxicity. Western blot analysis of (A) transient and (B) tetracycline-inducible overexpression of ABL1-T315I in H1915 cells treated with dasatinib or imatinib."
NCBI gene IDs:
"ABL1: 25"
Figure legend: "C. CFA with dasatinib or imatinib for H1915 cells with or without tetracycline-inducible expression of ABL1-T315I. Error bars represent mean ±S.E.M., n=9, *P&lt;0.001 by two-tailed unpaired Student's t-test (control, DMSO vs dasatinib P=4.3×10-12 vs imatinib P=6×10-6; dasatinib, control vs tetracycline, P=9×10-7; imatinib, control vs tetracycline P=9.7×10-5)."
NCBI gene IDs:
"ABL1: 25"