EMBO/SourceData huggingface dataset:
Figure legend: "D Steady state levels of mitophagy related proteins VDAC1, p62 and LC3-II in control and TIMM50 mutant fibroblasts growing in either glucose or galactose were assessed by Western blot using GAPDH as internal control. E Quantification of the steady state levels of VDAC1, p62 and LC3-II in control and TIMM50 mutant fibroblasts growing in either glucose or galactose. Data are shown as mean ± SD, n = 4 biological replicates; ∗∗p &lt; 0.01, ∗*∗p &lt; 0.001 grouping both controls together."
NCBI gene IDs:
"TIMM50: 92609"
Figure legend: "A Cell size in control and TIMM50 mutant fibroblasts, transduced with the empty vector (EV) or with wild-type TIMM50 grown in glucose or galactose. Data are shown as mean ± SD, n = 5 biological replicates; ∗p &lt; 0.05, ∗∗p &lt; 0.01, ∗*∗p &lt; 0.001."
NCBI gene IDs:
"TIMM50: 92609"
Figure legend: "B Growth curves of control and TIMM50 mutant fibroblasts, transduced with the empty vector (EV) or with wild-type TIMM50 grown in glucose or galactose. Cell growth was monitored continuously by the Incucyte live cell imager (Essen Bioscience). One of the three independent experiments carried out is presented. Data are shown as mean of three technical replicates ± SD."
NCBI gene IDs:
"TIMM50: 92609"
Figure legend: "C Plot of Annexin V intensity against propidium iodine signal in control and TIMM50 mutant fibroblasts, transduced with the empty vector (EV) or with wild-type TIMM50 grown in glucose or galactose. Cells in the late stage of apoptosis are boxed in the top right corner."
NCBI gene IDs:
"TIMM50: 92609"
Figure legend: "D Quantification of the number of late apoptotic cells in control and TIMM50 mutant fibroblasts, transduced with the empty vector (EV) or with wild-type TIMM50 grown in glucose or galactose. Data are shown as mean ± SD, n = 5 or 4 biological replicates in the case of transduced cells; ∗*∗p &lt; 0.001."
NCBI gene IDs:
"TIMM50: 92609"
Figure legend: "A Western-blot of whole cell extracts for TIMM50 and GAPDH in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts grown in either glucose or galactose containing medium."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "B Mitochondrial membrane potential in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts grown in glucose or galactose using JC-1 staining in untreated or FCCP treated conditions. Data are shown as mean ± SD, n = 4 biological replicates; ∗p &lt; 0.05, ∗∗p &lt; 0.01, ∗*∗p &lt; 0.001."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "C Western blot for representatives of all five respiratory complexes in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts grown in glucose or galactose. GAPDH is from the same blot as panel A. Quantification based on two biological replicates for RNASEH1 and ISCU mutant fibroblasts Significant changes in protein levels in RNASEH1 and ISCU mutant fibroblasts compared to controls have been boxed in red."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "D Oxygen consumption measurements in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts grown in glucose or galactose. Values of basal and maximal respiration along with ATP-production dependent, proton leak respiration and spare capacity are shown. Data are shown as mean ± SD, n = 4 biological replicates; ∗p &lt; 0.05, ∗∗p &lt; 0.01, ∗*∗p &lt; 0.001."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "E Steady state levels of ROS related proteins SOD2 and ACO2 and mitophagy related proteins VDAC1, p62 and LC3 in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts growing in either glucose or galactose were assessed by Western blot using GAPDH as internal control. GAPDH is from the same blot as panel A."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "F Quantification of the number of late apoptotic cells in control and TIMM50, RNASEH1 and ISCU mutant fibroblasts grown in glucose or galactose. Data are shown as mean ± SD, n = 4 or more biological replicates; ∗*∗p &lt; 0.001."
NCBI gene IDs:
"ISCU: 23479
RNASEH1: 246243
TIMM50: 92609"
Figure legend: "A The mRNA value of AKT2 was analyzed in the GEO Profiles from the  liver explant of  Hepatitis B virus (HBV)-associated acute liver failure (ALF) patients (GDS4387/225471_s_at), and from bronchial epithelial cells  with pandemic and seasonal H1N1 influenza virus infections in vitro (GDS4855/203808_at). normal, n=10; HBV, n=17; control, n=3; influenza A, n=9. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using unpaired t-test Error bars mean ± SD"
NCBI gene IDs:
"AKT2: 208"
Figure legend: "C The  qRT-PCR  analysis of Akt2  mRNA in PEMs  stimulated with  lipo-poly(I:C) (1 μg/mL), lipo-poly(A:T) (1 μg/mL),  lipo-ISD  (3 μg/mL) or HSV-1 (MOI, 1) for 6 hours. n=3, respectively. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using one-way ANOVA test Data are from three independent biological replicates Error bars mean ± SEM)."
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "D The mRNA of Akt2  (red line) and Ifnb1 (black line) were analyzed by qRT-PC  in the mock and VSV  (MOI, 1) or LM (MOI, 1)-stimulated PEMs  or BMDMs at the indicated  time. Mock and VSV, n=4; mock and  LM, n≥3."
NCBI gene IDs:
"Akt2: 11652
Ifnb1: 15977"
Figure legend: "G-H PEMs  were pretreated with DMSO or AKT2  inhibitor CCT128930  (10 μM) (G) for 2 hours, or knocked down of  Akt2 with siAkt2-1 (20 nM) for 48 hours (H), then the mRNA level of Ifnb1  was measured by  qRT-PCR after lipo-poly(I:C),  lipo-poly(A:T), lipo-ISD, VSV, or HSV-1  stimulation for another 6 hours. n=3, respectively. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using two-way ANOVA test Data are from three independent biological replicates Error bars mean ± SEM)."
NCBI gene IDs:
"Akt2: 11652
Ifnb1: 15977"
Figure legend: "A-B qRT-PCR detection for the mRNA  expression  of Ifnb1 (A), Ifna4, Cxcl10  and Ccl5 (B) in WT (n=3) and Akt2  KO (n=3)  PEMs stimulated with lipo-poly(I:C), VSV,  lipo-poly(A:T), lipo-ISD or HSV-1 for 6 hours. C The  expression  of Ifnb1 mRNA level by  qRT-PCR  in WT (n=3) and Akt2 KO (n=3)  PEMs treated with poly(I:C) (10 μg/mL) for 6 hours (left panel) or LPS  (1 μg/mL) for 2 hours (right panel). Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using two-way ANOVA test Data are from three independent experiments Error bars mean ± SEM"
NCBI gene IDs:
"Akt2: 11652
Ccl5: 20304
Cxcl10: 15945
Ifna4: 15967
Ifnb1: 15977"
Figure legend: "H  Zebrafish larvae were overexpressed the indicated protein for 48 hours and challenged with VSV for another 6 hours, then the mRNA levels of  ifn1 in zebrafish larvae were measured by qRT-PCR (left panel). Every dot represents three  zebrafish embryos. Horizontal square bracket shows the statistical analysis of the comparison with 'PBS mock', the rest shows the comparison with 'PBS VSV'. PBS mock, n=5;  PBS VSV, n=13; AKT2 VSV, n=7; AKT2-T309A/S474A  VSV, n=9. H&amp;E staining (middle panel) and survival rates (Kaplan-Meier curve) (right panel) were collected from  zebrafish larvae after  VSV micro-injection for 18 hours or longer. The arrows indicated the  VSV-infected eye  and  skeletal muscle in  zebrafish larvae. Bars, 100 μm. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using a one-way ANOVA test or log-rank (Mantel-Cox) test Data are from three independent biological replicates Error bars mean ± SD)."
NCBI gene IDs:
"AKT2: 378972
ifn1: 360134"
Figure legend: "D WT and  Akt2  KO  PEMs were infected with or without VSV for 6 hours. Then, cell lysates of WT or  Akt2 KO  PEMs were prepared for immunoprecipitation  using anti-AKT2  antibody, followed by  immunoblotting  using anti-IRF3 antibody (left panel). Alternatively, cell lysates were prepared for immunoprecipitation  using anti-IRF3 antibody, followed by immunoblotting using anti-AKT2  antibody (right panel) to detect the endogenous interaction between AKT2 and IRF3. Data information: * Data are representative of two or three independent biological replicates"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "G Immunofluorescent  microscopic imaging for (left panel) and statistics analysis (right panel) for IRF3 nuclear translocation in WT and Akt2 KO PEMs at 6 hour post-VSV  infection. IRF3 (red), Nuclei  (Hoechst, green). The white arrows indicate the nuclei  with IRF3 translocation. Mock, n=2; VSV, n=3. Bar, 20 μm. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using two-way ANOVA test Data are representative of two or three independent biological replicates Error bars mean ± SEM)."
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "H Immunoassay of  IRF3, AKT2, LaminB1  and GAPDH  in the  nuclear and cytoplasmic fractions from the WT and Akt2  KO PEMs after VSV treatment for 6 hours.  Tubulin  and  LaminB1 were used as cytoplasmic  and nucleic protein loading control respectively. Data information: * Data are representative of two or three independent biological replicates"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "D  Immunofluorescence microscopy (top panel) of  AKT2-,  Flag-IRF3- or  Flag-IRF3-T207A-overexpressed  MEF cells after  poly(A:T) stimulation for 6 hours. Flag (IRF3, red) and Hoechst (nuclei, blue). Immunoassay  of nuclear-cytoplasm extractions (bottom panel) from  HEK293T-IRF3 KO cells with overexpression of the indicated plasmids for 24 hours followed by  VSV  infection for 6 hours.  GAPDH  and  SP1  were used as cytoplasmic  and nucleic protein loading control respectively. Bar, 20 μm. Data information: * Data are representative of three independent experiments"
NCBI gene IDs:
"Flag: 
AKT2: 208
IRF3: 3661"
Figure legend: "G qRT-PCR analysis of the  VSV  copies in overexpressed zebrafish embryos with the VSV  challenge at 18 hours later. Every dot represents three zebrafish embryos. Horizontal vertical square bracket shows the statistical analysis of comparison with 'PBS  mock', the rest shows the comparison with 'PBS VSV'. PBS mock, n=15; PBS VSV, n=9; IRF3 VSV, n=16; IRF3-T207A VSV, n=11; AKT2 VSV, n=14; AKT2-T309A/S474A VSV, n=9; IRF3 + AKT2 VSV, n=9; IRF3 + AKT2-T309A/S474A VSV, n=13; IRF3-T207A + AKT2 VSV, n=10. Data information: *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001 and ns, not significant (P &gt; 0.05); using a one-way ANOVA test Data are representative of three independent experiments Error bars mean ± SD)."
NCBI gene IDs:
"AKT2: 378972
IRF3: 564854"
Figure legend: "B  Survival  rates of WT and Akt2 KO  mice after lethal dose injection of VSV  during 120 hours (1 × 107 PFU/g, i.v.). Data information: *P &lt; 0.05, **P &lt; 0.01; using a log-rank (Mantel-Cox) test Data are representative of three independent experiments respectively"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "E WT and  Akt2  KO mice were injected with VSV  for 24 hours (1 × 106 PFU/g, i.v.). Representative images of the  VSV infected cells (GFP) were collected by fluorescence microscope (left panel) and the VSV  copies (WT, n=6; Akt2 KO n=7) were measured by qRT-PCR (right panel) in the liver of mice. Bar, 100 μm. Data information: *P &lt; 0.05, **P &lt; 0.01; using a unpaired t-test Data are representative of three independent experiments respectively in which the different groups of mice were sacrificed and quantified for indicated experimental purposes Error bars mean ± SD)."
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "Bone marrow cells  from WT and Akt2 KO mice  (CD45.2) were adoptively transferred to lethally irradiated CD45.1 mice  and infected with VSV. representative images were analyzed Data information: * Data are representative of three independent experiments respectively"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "immunoblot  analysis of  IRF3,  LaminB1 and GAPDH in the PIC  nuclear  and cytoplasmic fractions (C) from WT and Akt2 KO mice  treated with TMPD  for 2 weeks. GAPDH and LaminB1 were used as cytoplasmic and  nucleic protein loading control respectively. Data information: * Data are representative of three independent experiments"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "H&amp;E-staining  (E left panel) and immunofluorescence of IgG  deposits (E right panel) in the kidney  sections were collected from WT and Akt2  KO bone marrow-reconstituted  CD45.1 mice Bar, 50 μm. Data information: * Data are representative of three independent experiments"
NCBI gene IDs:
"Akt2: 11652"
Figure legend: "J. qRT-PCR analysis of the relative mRNA  expression levels of AKT2 (left panel) and IFNA  (middle panel) or  IFNβ1 (right panel) in CD14  positive monocytes isolated from SLE patients  (n=9) or healthy donors (n=9). Data information: *P &lt; 0.05, **P &lt; 0.01 and ****P &lt; 0.0001; using unpaired t-test or correlation analyses Data are pooled from different individuals Error bars mean ± SD)."
NCBI gene IDs:
"AKT2: 208
IFNA: 3439///3443///3451///3452///3447///3446///3441///3448///3444///3445
IFNβ1: 3456"
Figure legend: "The protein levels of CD14  and CD301  in CD301- macrophages  and CD301+ macrophages  examined by western blot (n=3 technical replicates for each group). Data are presented as mean ± SEM. Two-tailed Student's t-test. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001. NS, not significant."
NCBI gene IDs:
"CD301: 10462"
Figure legend: "The protein levels of Fibronectin, Collagen 1, α-SMA  and CTGF  expression in primary human endometrial stromal cells (hESCs) treated by the supernatants of CD301- and CD301+ macrophages  for 48h, respectively examined by  western blot (n=3 technical replicates for each group). Data are presented as mean ± SEM. Two-tailed Student's t-test. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001. NS, not significant."
NCBI gene IDs:
"CD301: 10462"
Figure legend: "The protein levels of GAS6  and CCL8 expression  in sorted human endometrial CD301- and CD301+ macrophages  (n=3 technical replicates for each group). Data are presented as mean ± SEM. Two-tailed Student's t-test. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001. NS, not significant."
NCBI gene IDs:
"CD301: 10462"
Figure legend: "Western blot  analysis of α-SMA  and Collagen 1  in hESCs  treated with Bemcentinib  (1μM) for 1 hour, followed by GAS6  (50ng/mL) for 72h (n=3 technical replicates for each group). Western blot  analysis of α-SMA and Collagen 1 in hESCs  treated with the supernatants of CD301- and CD301+ macrophages  and GAS6  neutralizing antibody (2.5μg/mL) for 72h (n=3 technical replicates for each group). Data are presented as mean ± SEM. One-way ANOVA with Tukey's post hoc analysis. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001. NS, not significant."
NCBI gene IDs:
"CD301: 10462"
Figure legend: "qRT-PCR analysis of ACTA2  and COL1A1  expression in hESCs  treated with GAS6  (50ng/mL) or JSH23  (10μM) for 72h (n=3 biological replicates for each group). Data are presented as mean ± SEM. One-way ANOVA with Tukey's post hoc analysis. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001."
NCBI gene IDs:
"ACTA2: 59
COL1A1: 1277"
Figure legend: "qRT-PCR analysis of Acta2  and Col1a1  expression in the uterus  of Sham, IUA  and IUA+DT mice  (n=5 mice  for each group). Data are presented as mean ± SEM. One-way ANOVA with Tukey's post hoc analysis. *, P&lt;0.05; **, P&lt;0.01; ***, P&lt;0.001."
NCBI gene IDs:
"Acta2: 11475
Col1a1: 12842"
Figure legend: "qRT-PCR analysis of Acta2  and Col1a1  expression in the uterus  of IUA+PBS  and IUA+BEM mice  (n=5 mice  for each group). Data are presented as mean ± SEM. (B, Two-tailed Student's t-test."
NCBI gene IDs:
"Acta2: 11475
Col1a1: 12842"
Figure legend: "SARS-CoV-2.For weigh loss record, hACE2 mice (n=7) and WT mice (n=3) were experimentally challenged intranasally with SARS-CoV-2, and the ACE2-Mock mice (n=3) were used as control. And then the weight loss was recorded over 14 days (a, ANOVA, ***p&lt;0.001)."
NCBI gene IDs:
"ACE2: 59272
hACE2: 59272"
Figure legend: "To screen virus replication, 12 mice were infected in each group, and 3 mice per group were sacrificed and their major organs harvested for viral load and virus titer at 1 dpi, 3 dpi, 5 dpi and 7 dpi respectively. The distribution of SARS-CoV-2 in the primary organs of ACE2-HB-01 mice was detected by qRT-PCR (b)."
NCBI gene IDs:
"ACE2: 59272"
Figure legend: "the virus isolated from lungs of ACE2-HB-01 mice at 3 dpi was observed by electron microscope (d)."
NCBI gene IDs:
"ACE2: 59272"
Figure legend: "mice.a. Gross pathology and histopathology of lungs from WT-HB-01 mice (3 dpi), ACE2-Mock mice (3 dpi) and ACE2-HB-01 mice (3 dpi and 5 dpi). Postmortem examinations showed focal dark red lesions (red arrow) throughout the dorsal of the right middle lobe of the lung at 3dpi. The lesions progressed into multifocally scattered-dark reddish purple areas and palpable nodules (red arrow) throughout the right lobe of the lung at 5 dpi. Histopathological observation indicated that moderate interstitial pneumonia with thickened alveolar septa (black arrows) and infiltration of lymphocytes (red arrows). The swollen and degenerative alveolar macrophages (green arrows) are scattered within the alveolar cavities at 3dpi and 5 dpi."
NCBI gene IDs:
"ACE2: 59272"
Figure legend: " Immunofluorescence analysis of viral antigens in lungs of SARS-CoV-2-infected hACE2 mice.Co-localization of SARS-CoV-2 S protein and hACE2 receptor in hACE2 mouse lungs, the sections were incubated with anti-SARS-CoV-2 S protein antibody, anti-human ACE2 antibody, and DAPI. The lung sections of ACE2-Mock mice (a-d). The lung sections of ACE2-HB-01 mice (e-h). The white arrows showed the viral S protein (f) and hACE2 (g), respectively, the yellow arrow showed the merge of viral S protein and hACE2 (h). White bar=25 µm. "
NCBI gene IDs:
"ACE2: 59272
hACE2: 59272"
Figure legend: "(A) Relative values (RV) of p62 mRNA level in frontal lobe of SIVE versus SIV and uninfected (UN) monkeys, n = 7 for SIVE, n = 12 for SIV and n = 9 for UN, P&lt;0.05."
NCBI gene IDs:
"p62: 712783"
Figure legend: "B) RV of p62 mRNA level in frontal cortex of HAD versus non neurological diseased subjects (NNDS), n = 8 for HAD and n = 10 for NNDS, P&lt;0.0001."
NCBI gene IDs:
"p62: 51164"
Figure legend: "A Representative pictures of embryos at 18.5 days postcoitum (E18.5) and hematoxylin and eosin staining of whole-mount embryo sections from PR-SET7loxp/Alfp-Cre (PR-SET7ΔHepE) mice and control littermates (WT)."
NCBI gene IDs:
"Alfp: 
Cre: 
PR-SET7: 67956"
Figure legend: "D qPCR analysis of Albumin,Afp and HNF4 mRNA levels. Bars represent mean values of mRNA levels normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA and SEM from samples of four individual mice. *P-value &lt; 0.01."
NCBI gene IDs:
"GAPDH: 
Afp: 11576
Albumin: 11657
HNF4: 15378"
Figure legend: "A Macroscopic appearance of livers in 120-day-old (P120) wild-type (WT) and PR-SET7loxp/Alb-Cre (KO) mice. Note, small adenomatous foci in KO livers."
NCBI gene IDs:
"Alb: 
Cre: 
PR-SET7: 67956"
Figure legend: "B Representative hematoxylin and eosin staining of liver sections from P120 wild-type (WT) and PR-SET7loxp/Alb-Cre (PR-SET7ΔHepA) mice. Arrows show three areas containing morphologically different hepatocytes. Right panels: zoom-in to Area-A-'normal zone', to Area-B-'necrotic zone' and to Area-C-'regenerative zone'."
NCBI gene IDs:
"Alb: 
Cre: 
PR-SET7: 67956"
Figure legend: "C Immunohistological staining of liver sections from P120 PR-SET7ΔHepA mice and control littermates (WT) with HNF4 antibody."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "D TUNEL staining of liver sections from P120 PR-SET7ΔHepA mice and control littermates (WT). Note that cells containing enlarged nuclei (white arrows) are TUNEL negative."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "A Electronmicroscopic images of cells containing enlarged nuclei in P120 PR-SET7ΔHepA livers and normal hepatocytes in control littermates (WT). White arrows indicate: (Nuc) nuclei; (ER) endoplasmic reticulum; (Mit) mitochondrium; (PM) plasma membrane; (a) swollen mitochondria; (b) swollen endoplasmic reticulum; (c) disorganized endoplasmic reticulum; (d) disrupted plasma membrane; and (e) disorganized pieces of endoplasmic reticulum encircling mitochondria to form autophagosomes."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "B Immunohistological staining of liver sections from P120 PR-SET7ΔHepA mice and control littermates (WT) with H4K20Me1 and H4K20Me3 antibodies. Normal (Area-A), Necrotic (Area-B) and Regenerative (Area-C) hepatocyte-containing areas are indicated. Arrows show the loss of H4K20Me1 signal from the large necrotic nuclei."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "C-F Partial (2/3rd) hepatectomy was performed in 45-day-old PR-SET7ΔHepA mice and control littermates (WT). Two weeks later, at postnatal day 60 (P60) liver sections were stained with hematoxylin and eosin (C) or γH2AX (D) or H4K20Me1 (E) or HNF4 and F4/80 (F) antibodies."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "A, B Immunohistological staining of liver sections from P120 PR-SET7ΔHepA mice and control littermates (WT) with Ki67, albumin (Alb) and A6 or HNF4 antibodies as indicated. Arrows depict the different areas in the sections as indicated above (Fig.1B). Asterisks (*) indicate Ki67+ hepatocytes. Small arrows (&gt;) indicate Ki67+ non-hepatic cells. Note the lack of co-staining of cells with HNF4 and A6 antibodies."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "C Immunohistological staining of liver sections from P120 PR-SET7ΔHepA mice and control littermates (WT) with FGF7 and A6 antibodies."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "D Relative mRNA levels of FGF7. Bars represent mean FGF7 mRNA levels normalized to GAPDH mRNA and SEM from samples of 5 individual 45 days or 120-day-old mice. The data are presented as fold over values obtained with wild-type P45 samples. *P-value &lt; 0.01."
NCBI gene IDs:
"GAPDH: 
FGF7: 14178"
Figure legend: "A Analysis of reactive oxygen species (ROS) accumulation in frozen liver sections from 120-day-old (P120) and 240-day-old (P240) PR-SET7ΔHepA mice and control littermates (WT)."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "D Macroscopic appearance of livers in P240 PR-SET7ΔHepA mice and control littermates (WT)."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "F Representative hematoxylin and eosin staining of liver sections from P240 PR-SET7ΔHepA mice and control littermates (WT). Two different magnifications are shown."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "G Relative mRNA levels of selected oncofetal genes. Bars represent mean Afp, H19, GPC-3 and CTGF mRNA levels normalized to GAPDH mRNA and SEM from samples of 5 individual 240-day-old mice. The data are presented as fold over values obtained with wild-type samples. *P-value &lt; 0.01."
NCBI gene IDs:
"GAPDH: 
Afp: 11576
CTGF: 14219
GPC-3: 14734
H19: 14955"
Figure legend: "A, B Immunohistological staining of liver sections from P240 PR-SET7ΔHepA mice and control littermates (WT) with Afp and HNF4 (A) or Ki-67 and albumin (Alb) (B) antibodies."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "C-E Double staining of liver sections with A6 and HNF4 (C) or Sox9 and Alb (D) or CD133 and HNF4 (E) antibodies. Right panels show larger magnifications of stainings performed in PR-SET7ΔHepA liver sections."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "A P240 PR-SET7ΔHepA liver sections were double-stained with A6 and Sox9 (upper panel) or CD133 and Sox9 (lower panel). Pie charts at the right represent average percentages of cells stained positively with the indicated markers after counting DAPI-stained cells in 5 high-power fields (HPF) in liver sections of 3 different mice."
NCBI gene IDs:
"PR-SET7: 67956"
Figure legend: "B Cell duplication rate of primary hepatocytes from P240 PR-SET7ΔHepA livers in culture."
NCBI gene IDs:
"PR-SET7: 67956"