EMBO/SourceData huggingface dataset:
Figure legend: "B ChIP assays to detect ub-H2B binding at E-box, TSS and gene body of tim, Pdp1ε, per and clk in Nipped-A RNAi (timG4/+;Udcr2/UNipped-ARNAi-1) and control (timG4/+;Udcr2/+) (n≥3). Data information: Student's t-test, *P &lt; 0.05. Two-way ANOVA, significant effect between ub-H2B and IgG were found for all genomic regions tested (P&lt;0.001). Significant effect of genotypes were found for tim E-box (P&lt;0.05), Pdp1ε E-box (P&lt;0.01), tim TSS (P&lt;0.01) and Pdp1ε TSS (P&lt;0.001)."
NCBI gene IDs:
"clk: 38872
dcr2: 36993
G4: 855828
Nipped-A: 35483
Pdp1ε: 45588
per: 31251
tim: 33571"
Figure legend: "A, B The period (A) and power (B) of DD locomotor rhythms of flies with not knocked down and controls. Digits on the bar are the number of flies tested. Percentage of rhythmicity is indicated above the bars. Statistical difference is measured using one-way ANOVA, P&lt;0.001, Tukey's multiple comparison test, **P&lt;0.01, ***/###/+++/$$$P&lt;0.001, * compared with the G4 control, # compared with the UAS control, + compared with the Nipped-A RNAi flies, $ compared with the not overexpression flies. White bar indicates UAS or GAL4 controls. Dashed bar indicates flies with genetically manipulated not. Gray bar indicates flies with Nipped-A knocked down. Checked bar indicates flies with both genetically manipulated not and Nipped-A knocked down."
NCBI gene IDs:
"G4: 855828
GAL4: 855828
Nipped-A: 35483
not: 40030"
Figure legend: "C Plots of relative mRNA abundance vs CT for clock genes determined by qRT-PCR in whole head extracts of not RNAi (timG4/+;Udcr2/UnotRNAi) and control (timG4/+;Udcr2/+) collected on DD1 (n=5)."
NCBI gene IDs:
"dcr2: 36993
G4: 855828
not: 40030
tim: 33571"
Figure legend: "D ChIP assays to detect ub-H2B binding at E-box, TSS and gene body of tim and Pdp1ε in not RNAi (timG4/+;Udcr2/UnotRNAi) and control (timG4/+;Udcr2/+) (n=3). Student's t-test, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001. Statistical difference is measured using two-way ANOVA, P&lt;0.001, significant effect of genotypes were found for tim E-box (P&lt;0.01), Pdp1ε E-box (P&lt;0.05), tim TSS (P&lt;0.05) and Pdp1ε TSS (P&lt;0.001) and tim gene body (P&lt;0.01). G4, GAL4; U, UAS."
NCBI gene IDs:
"dcr2: 36993
G4: 855828
GAL4: 855828
not: 40030
Pdp1ε: 45588
tim: 33571"
Figure legend: "E, F The period of DD locomotor rhythm of flies when knocking down Nipped-A and over-expressing not. Digits on the bar are the number of flies tested. Percentage of rhythmicity is indicated above the bars. Statistical difference is measured using one-way ANOVA, P&lt;0.001, Tukey's multiple comparison test, **P&lt;0.01, ***/###/+++/$$$P&lt;0.001, * compared with the G4 control, # compared with the UAS control, + compared with the Nipped-A RNAi flies, $ compared with the not overexpression flies. White bar indicates UAS or GAL4 controls. Dashed bar indicates flies with genetically manipulated not. Gray bar indicates flies with Nipped-A knocked down. Checked bar indicates flies with both genetically manipulated not and Nipped-A knocked down."
NCBI gene IDs:
"G4: 855828
GAL4: 855828
Nipped-A: 35483
not: 40030"
Figure legend: "G The period of DD locomotor rhythm of flies co-expressing Nipped-A RNAi and not RNAi. Digits on the bar are the number of flies tested. Percentage of rhythmicity is indicated above the bars. Statistical difference is measured using one-way ANOVA, P&lt;0.001, Tukey's multiple comparison test, **P&lt;0.01, ***/###/+++/$$$P&lt;0.001, * compared with the G4 control, # compared with the UAS control, + compared with the Nipped-A RNAi flies, $ compared with the not overexpression flies. White bar indicates UAS or GAL4 controls. Dashed bar indicates flies with genetically manipulated not. Gray bar indicates flies with Nipped-A knocked down. Checked bar indicates flies with both genetically manipulated not and Nipped-A knocked down."
NCBI gene IDs:
"G4: 855828
GAL4: 855828
Nipped-A: 35483
not: 40030"
Figure legend: "A Number of differentially up- and down-regulated genes (DEG) in RNAi-ASCO1 seedlings as compared to wild type (WT) according to the RNA-seq data (FDR &lt; 0.01, |log2FC| &gt;= 0.75). B Fraction of DEG found in each transcript class as defined in the Araport11 gene annotation. AS stands for antisense."
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: " D Representative picture of 14-day-old plants grown 9 days in liquid 1/2MS supplemented with 1 µM flg22. The scale bar representing 0.6cm is included in the picture. E Lateral root density of WT and two independent RNAi-ASCO lines 9 days after transfer in 1/2MS supplemented with 0.1 µM or 1 µM flg22. "
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: " F Representative picture of root apical meristems after cell wall staining, in response to flg22. TZ: Transition Zone; QC: Quiescent Center. G Root apical meristem size of WT and RNAi-ASCO1 (eg distance from QC to TZ in µm). "
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: "B Number of genes containing at least one differential RNA processing event (as defined by RNAprof p.adj &lt; 0.001) in CDS, introns, 5'UTR and 3'UTR between RNAi-ASCO1 and WT. Up and Down fractions correspond to increase or decrease, respectively, of RNA-seq coverage in RNAi-ASCO1 for each specified gene feature."
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: " B Scatter plot showing the respective gene expression fold change in RNAi-ASCO and 35S:ASCO lines as compared to WT. Genes showing significant changes in RNAi-ASCO and 35S:ASCO are highlighted as yellow and blue dots, respectively. "
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: " C Scatter plots showing the respective Percent Spliced In difference (dPSI) in RNAi-ASCO and 35S:ASCO lines as compared to WT. Genes showing significant changes in RNAi-ASCO, 35S:ASCO or in both lines are highlighted as red, green or blue dot, respectively. Gray dots represent all AS events. "
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: " Analyses of RT-PCR products of SR34 transcripts on 8% acrylamide gel. Quantification of the ratio of SR34 isoforms detected in the gel in (B) RNAs were extracted from WT and RNAi-ASCO1 14-day-old plants. The asterisk (*) indicates a significant difference as determined by Student's T test (p &lt; 0.05, n = 3 biological replicates). Error bars show mean +/- standard deviation. "
NCBI gene IDs:
"ASCO: 6240510
SR34: 839262"
Figure legend: " Analyses of RT-PCR products of NUDT7 transcripts on 8% acrylamide gel. Quantification of the ratio of NUDT7 isoforms detected in the gel in (E) respectively. RNAs were extracted from WT and RNAi-ASCO1 14-day-old plants. The asterisk (*) indicates a significant difference as determined by Student's T test (p &lt; 0.05, n = 3 biological replicates). Error bars show mean +/- standard deviation. "
NCBI gene IDs:
"ASCO: 6240510
NUDT7: 826884"
Figure legend: " A Analysis of ASCO enrichment by ChIRP using two sets of independent biotinylated probes ODD and EVEN compared to negative control with probes designed against the LacZ RNA. The fold enrichment was calculated between ODD or EVEN samples against LacZ. These samples were used for protein precipitation and Mass Spectrometry analyses (ChIRP-MS), from which PRP8a was identified as a potential ASCO partner. "
NCBI gene IDs:
"LacZ: 
ASCO: 6240510"
Figure legend: " B Validation of PRP8a-ASCO interaction by PRP8a-RIP. U5 RNA was used as a positive control. Data information: In , the results are expressed as a percentage of the Input for PRP8a RIP followed by RT-qPCR "
NCBI gene IDs:
"ASCO: 6240510
U5: 836235"
Figure legend: " A ASCO transcript levels in WT and prp8-7 mutants. "
NCBI gene IDs:
"ASCO: 6240510
prp8: 844347"
Figure legend: "prp8-7 leaky mutant displays similar AS events as observed in RNAi-ASCO. Quantification of SR34 isoforms splicing index by RT-qPCR."
NCBI gene IDs:
"ASCO: 6240510
SR34: 839262
prp8: 844347"
Figure legend: " C prp8-7 leaky mutant displays similar AS events as observed in RNAi-ASCO. Quantification of ESP isoforms splicing index by RT-qPCR. "
NCBI gene IDs:
"ASCO: 6240510
ESP: 841842
prp8: 844347"
Figure legend: " D ASCO transcript levels in smd1b mutant. In A and D RNAs were extracted from WT, prp8-7 and smd1b 14-day-old plants. "
NCBI gene IDs:
"ASCO: 6240510
smd1b: 828163
prp8: 844347"
Figure legend: " E SmD1b can bind ASCO in vivo. U6 RNA was used as a positive control and a housekeeping gene (HKG2, AT4G26410) RNA as a negative control. "
NCBI gene IDs:
"ASCO: 6240510
AT4G26410: 828747
U6: 835191
HKG2: 833552"
Figure legend: " F SmD1b recognizes in vivo the RNAs of 4 genes regulated by ASCO. In E and F the results were expressed as % INPUT in SmD1b-GFP RIP and IgG RIP used as a negative control. "
NCBI gene IDs:
"ASCO: 6240510"
Figure legend: "smd1b mutant displays similar AS events as observed in RNAi-ASCO. Quantification of SR34 isoforms splicing index by RT-qPCR."
NCBI gene IDs:
"ASCO: 6240510
smd1b: 828163
SR34: 839262"
Figure legend: " H smd1b mutant displays similar AS events as observed in RNAi-ASCO. Quantification of ESP isoforms splicing index by RT-qPCR. "
NCBI gene IDs:
"ASCO: 6240510
smd1b: 828163
ESP: 841842"
Figure legend: "E. The endouc and ela3l (negative control) mRNAs were separately microinjected into zebrafish embryos from huORFZ at a one-cell stage. Upper panels: observation of GFP signal expressed in huORFZ embryos at 72 hpf. Lower panels: magnification of pictures corresponding to the upper panels."
NCBI gene IDs:
"ela3l: 554107
endouc: 562040"
Figure legend: "D, E. The cleavage activity of Endouc was studied using materials presented at each lane. EndoucK242A: Endouc mutant; Extract: incubated in cell extracts; and Buf: reaction buffer. RNA probe without adding reaction buffer served as a negative control. The predicted cleavage sites (U) were mutated to generate mutant huORFchop transcript (unlabelled huORF-mt) and labelled by biotin (biotin-huORF-mt). Unlabelled competitor RNA was added in reactions at five times higher than that of the biotinylated probe."
NCBI gene IDs:
"Endouc: 562040"
Figure legend: "A. HEK 293T cells were transfected with pCS2 vector (black), pCS2-Endouc (red), and pCS2-EndoucK242A (green) for 24 hr and subjected to either DMSO (control) or thapsigargin (TH; stress) treatment for 1 hr. The lysates of transfected cells were applied to polysome profile analysis (PPA). The sucrose gradient from top to bottom was shown from left to right, respectively. The sedimentation of 40S, 60S, 80S, and polysomes was indicated. Lysate from control, Endouc-expressing, and EndoucK242A-expressing cells were applied to PPA. The resulting fractions were TCA-precipitated, analysed by SDS-PAGE, and subjected to Western blot using antibodies against Flag and S6."
NCBI gene IDs:
"Endouc: 562040"
Figure legend: "B. The luc activity of Fluc (solid column) versus Rluc (blank column) in HEK 293T cells transfected with bicistronic mRNAs shown in Figures A was presented as an increase in fold over that obtained from control group of RF which was normalized as 1. These data suggested that the change of Fluc/Rluc ratio shown in Figures A was entirely dependent on the change of Fluc activity. The data were averaged from three independent experiments and presented as mean ± S.D. (n = 3). Student's t test was used to determine significant differences between each group (**: P&lt;0.005)."
NCBI gene IDs:
"Fluc: 
luc: "
Figure legend: "D. The luc activity of Fluc (solid column) versus Rluc (blank column) in HEK 293T cells transfected with bicistronic mRNAs shown in Figures C was presented as an increase in fold over that obtained from control group of hpRF which was normalized as 1. These data suggested that the change of Fluc/Rluc ratio shown in Figures C was entirely dependent on the change of Fluc activity. The data were averaged from three independent experiments and presented as mean ± S.D. (n = 3). Student's t test was used to determine significant differences between each group (***: P &lt;0.001)."
NCBI gene IDs:
"Fluc: 
luc: "
Figure legend: "A-F. Schematic representation of capped (m7G-capped) and A-capped (non-functional capped) monocistronic mRNAs with poly(A)-tail-encoded firefly luciferase (Fluc) and fused upstream with (A) c-myc IRES, (B) no insertion, (C) non-specific 105-nt luc RNA (Non105), (D) huORFchop-1-105-nt, (E) huORFchop-69-105-nt, and (F) huORFchop-81-105-nt as shown above each bar graph. The RNA transfection assay of each transcript equipped with m7G-capped or A-capped monocistronic mRNA in HEK 293T cells was compared. To normalize the luc activities of capped and A-capped Fluc transcripts, the m7G-capped Renilla luc (Rluc) mRNA was used as an internal control. The luc activity of cells transfected with Cap-monocistronic mRNA in each graph was set as 100%."
NCBI gene IDs:
"Fluc: 
luc: 
luciferase: 
chop: 561924
c-myc: 4609"
Figure legend: "GFP expression under Pdgfrb-promoter in mice is present in mesangial cells of glomeruli and interstitial cells of cortex and medulla, but not in tubular cells. Nuclei are stained with DAPI (blue). Scale bar = 50 µm"
NCBI gene IDs:
"Pdgfrb: 18596"
Figure legend: "Tissue clearing with Scale and 3D reconstruction of Pdgfrb-GFP reporter mice in a healthy and fibrotic kidney (UUO day 5) shows the expansion of Pdgfrb expressing cells in fibrosis."
NCBI gene IDs:
"GFP: 
Pdgfrb: "
Figure legend: "Representative Ki67 immunofluorescence staining (green) in wt and Foxd1Cre::Pdgfrb+/J mice, showing increased proliferation in the transgenic mice. Glomeruli are outlined with circles, arrowheads point to Ki67 positive interstitial cells. Nuclei are stained with DAPI (blue). Scale bar = 50 µm."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Quantification of proliferating Ki67-positive cells specifically in glomeruli (C), interstitium (D) and tubules (E) in Foxd1Cre::Pdgfrb+/J mice (black bars) and wt mice (white bars) of 6, 14, 25 and 35 weeks of age. Foxd1Cre::Pdgfrb+/J mice exhibited increased proliferation of glomerular and interstitial cells, whereas tubular epithelial cell proliferation was not altered. Data in C, D and E are shown as means ± SD of n = 3 animals per group."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "FoxD1-reporter mice (Foxd1::tdTomato) confirmed the expansion of mesenchymal cells in 14 weeks old Foxd1Cre::Pdgfrb+/J mice both in glomeruli and interstitium. Circles outline glomeruli. Scale bar = 50 µm. Quantification of FoxD1-Tomato positive cells in the cortical interstitium in 14 weeks old Foxd1Cre::Pdgfrb+/J and wt mice confirmed the significantly increased expansion of mesenchymal cells by 42% in Foxd1Cre::Pdgfrb+/J mice. Cells were counted in six viewfields at 40x magnification. Bar graphs show means ± SD of n = 3 mice per group."
NCBI gene IDs:
"tdTomato: 
Cre: 2777477
FoxD1: 15229
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Isolated primary fibroblasts and mesangial cells from Foxd1Cre::Pdgfrb+/J mice have higher proliferation rates assessed by bromodeoxyuridine (BrdU) incorporation assay compared to cells from wt mice. Bar graphs show means ± SD, n = 4 per group, *: p≤0.05 compared to wt of same time point."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "PAS staining of glomeruli of 25 weeks old wt and of 6 and 35 weeks old Foxd1Cre::Pdgfrb+/J mice shows pathological changes of the glomeruli in Foxd1Cre::Pdgfrb+/J mice. Glomerular tuft size of Foxd1Cre::Pdgfrb+/J mice was significantly increased compared to wt mice during the time course."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Immunhistological staining of collagen I and its histomorphometric quantification (F) shows that collagen I deposits in an increasing manner in Foxd1Cre::Pdgfrb+/J mice during the time course."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Histological stainings and its histomorphometric quantification (B) of kidney cortex for α-SMA of wt (25 weeks) and Foxd1Cre::Pdgfrb+/J mice of an age of 6 and 35 weeks show expansion of myofibroblasts in the interstitium of the transgenic mice."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "The tubular stress marker Lipocalin-2 (LCN2) is not expressed in early time points but increases in time course in late stages when fibrosis is more prominent and mRNA level"
NCBI gene IDs:
"LCN2: 16819
Lipocalin-2: 16819"
Figure legend: "Creatinine clearance was measured in mice of an age of 10, 14, 25 and 35 weeks and decreased continuously in Foxd1Cre::Pdgfrb+/J mice, with a predicted complete loss of renal function 62 weeks in transgenic mice using linear regression analyses as described previously (Steiger et al, 2018). 10 weeks n = 5 wt and n = 4 Foxd1Cre::Pdgfrb+/J, 14 weeks n = 2 per group, 25 weeks n = 8 wt and n = 8 Foxd1Cre::Pdgfrb+/J, 35 weeks n = 3 per group "
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "The blood urea nitrogen (BUN) concentrations were higher in Foxd1Cre::Pdgfrb+/J mice compared to wt mice, apart from 25 weeks old group. Bar graphs show means ± SD, 10 weeks n = 7 wt and n = 5 Foxd1Cre::Pdgfrb+/J, 14 weeks n = 3 per group, 25 weeks n = 11 wt and n = 12 Foxd1Cre::Pdgfrb+/J, 35 weeks n = 3 per group"
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Erythrocyte numbers in Foxd1Cre::Pdgfrb+/J mice continuously. Horizontal lines are means ± SD of n = 3 per group. *: p≤0.05 compared to same wt of same time point."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "hematocrit in Foxd1Cre::Pdgfrb+/J mice continuously. Horizontal lines are means ± SD of n = 3 per group. *: p≤0.05 compared to same wt of same time point."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "hemoglobin content (C) decrease in Foxd1Cre::Pdgfrb+/J mice continuously. Horizontal lines are means ± SD of n = 3 per group. *: p≤0.05 compared to same wt of same time point."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "RNA in-situ hybridization (RNAScope) of Epo (green) and Pdgfrb (purple) in renal kidney cortex of 35 week old mice shows that EPO-producing cells co-express Pdgfrb. Foxd1Cre::Pdgfrb+/J mice have less EPO-producing cells (arrows) than wt mice."
NCBI gene IDs:
"Cre: 2777477
Epo: 13856
EPO: 13856
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "After induction of anemia by blood taking, the erythrocyte numbers recovered after one week in wt mice, whereas Foxd1Cre::Pdgfrb+/J mice were not able to recover their erythrocytes numbers at all. Data are means ± SD of n = 5 per group."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Five days after the induction of unilateral ureteral obstruction (UUO), a model of obstructive nephropathy and interstitial fibrosis, we assessed fibrosis (collagen I, α-SMA) and inflammation (F4/80), the classical read-out parameters in this model. Compared to wt mice with UUO, Foxd1Cre::Pdgfrb+/J mice developed significantly stronger fibrosis and inflammation (A). Representative pictures of the histological stainings are shown in (B). Scale bar = 50 µm All data in A and B show means ±SD, wt n = 4, Foxd1Cre::Pdgfrb+/J n = 3. *: p≤0.05 compared to wt"
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Angiotensin II infusion via an osmotic pump induced hypertension similarly in wt and Foxd1Cre::Pdgfrb+/J mice (C)."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "In this model of hypertensive injury, the kidney function and even the histopathology was largely unaffected in wt mice, whereas the Foxd1Cre::Pdgfrb+/J mice showed a significantly increased BUN values and prominent glomerulopathy after 28 days compared to the starting values (day 0), to wt animals after 28 days and to age-matched Foxd1Cre::Pdgfrb+/J mice without Angiotensin II infusion (D)."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Consistently the creatinine clearance per g bodyweight decreased in the hypertensive Foxd1Cre::Pdgfrb+/J mice (E)."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "PAS staining showed more prominent mesangial expansion and intratubular protein casts indicative of proteinuria only in hypertensive Foxd1Cre::Pdgfrb+/J mice."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "Hypertension did not induce mesangial expansion and activation in wt mice, but led to a significant increase in hypertensive Foxd1Cre::Pdgfrb+/J mice as visualized by α-SMA staining. (H) Histomorphometric analysis of α-SMA positive percentage of the glomerular tuft area."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Histomorphometric quantifications showed a significant reduction of α-SMA abundance in the glomerular tufts of imatinib treated Foxd1Cre::Pdgfrb+/J mice."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Glomerular cellularity evaluated by counting the total number of cells per glomerular tuft, normalized to the area, were significantly reduced in imatinib treated Foxd1Cre::Pdgfrb+/J mice compared to control mice."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Histomorphometric quantifications of collagen I showed no effect of imatinib treatment on mesangial sclerosis in the glomeruli (K), whereas reduced interstitial fibrosis in imatinib treated Foxd1Cre::Pdgfrb+/J mice compared to controls was found (L)."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Hemoglobin serum levels were significantly improved in imatinib treated mice."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Representative pictures of the histological stainings of α-SMA (left) and collagen I (middle: glomeruli, right: cortical interstitium). Scale bar = 50 µm"
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"
Figure legend: "22 weeks old Foxd1Cre::Pdgfrb+/J mice were treated with imatinib (daily gavage, 50mg/kg bodyweight for 21 days; Foxd1Cre::Pdgfrb+/J + imatinib) and were compared to control Foxd1Cre::Pdgfrb+/J mice receiving vehicle (water; Foxd1Cre::Pdgfrb+/J + water). Aged-matched wt mice are indicated as dashed lines. Total PDGFR-β protein levels were decreased in Foxd1Cre::Pdgfrb+/J mice after imatinib treatment, as shown using western blot (O) and its densitometric evaluation (P)."
NCBI gene IDs:
"Cre: 2777477
Foxd1: 15229
Pdgfrb: 18596"