EMBO/SourceData huggingface dataset:
Figure legend: "C shRNA targeting TRAF3IP3 (sh-TRAF3IP3) was transduced into Mavs-/- HEK293T cells. Twenty-four hours after transduction, cells were treated with puromycin (2 μg/mL) for forty-eight hours and then transfected with pcDNA3-FLAG-MAVS-(Region III only). Twenty-four hours after transfection, cells were infected with or without VSV for twelve hours. Cells were then collected and subjected to immunoprecipitation assay and immunoblotting."
NCBI gene IDs:
"FLAG: 
Mavs: 57506
MAVS: 57506
TRAF3IP3: 80342"
Figure legend: "D Wild type and Traf3ip3-/- HEK293T cells were transfected with pcDNA3-FLAG-MAVS-(Region III only). Twenty-four hours post-transfection, cells were infected with or without VSV. Twelve hours post-infection, cells were collected and subjected to immunoprecipitation assay and immunoblotting."
NCBI gene IDs:
"FLAG: 
MAVS: 57506
Traf3ip3: 80342"
Figure legend: "C-E Immunofluorescent microscopic imaging for TRAF3IP3. HeLa cells were transfected with pcDNA3-FLAG-TRAF3IP3. Twenty-four hours after transfection, cells were infected with or without SeV for twelve hours. Anti-FLAG M2 (FITC) was used for immunofluorescence staining of FLAG-TRAF3IP3. Nuclei were stained with DAPI. Mitochondria was stained with Mitotracker Red (C). Calnexin (an ER protein) was stained for ER (D). GM130 (a Golgi protein) was stained for Golgi (E). Scale bar represents 5 micrometers. F Quantitative analysis of yellow color as shown in Fig 5C, D and E, indicating TRAF3IP3 localization on various organelles with or without virus infection. The quantification was performed with ImageJ. All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. ***P&lt;0.001. NS indicates no statistically significant difference."
NCBI gene IDs:
"FLAG: 
TRAF3IP3: 80342"
Figure legend: "BMDMs from wild type, Traf3ip3-/- and Mavs-/- mice were treated with or without VSV, SeV, poly (I:C) or HSV-1 respectively as indicated for six hours. Ifnb (A), Ifna4 (B), Il6 induction was measured respectively by qPCR. All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05 and **P&lt;0.01. NS indicates no statistically significant difference."
NCBI gene IDs:
"Ifna4: 15967
Ifnb: 15977
Il6: 16193
Mavs: 228607
Traf3ip3: 215243"
Figure legend: "BMDMs from wild type, Traf3ip3-/- and Mavs-/- mice were treated with or without VSV, SeV, poly (I:C) or HSV-1 respectively as indicated for six hours. Il6 (C), Isg54 (D), and Cxcl10 (E) induction was measured respectively by qPCR. All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05 and **P&lt;0.01. NS indicates no statistically significant difference."
NCBI gene IDs:
"Cxcl10: 15945
Isg54: 15958
Il6: 16193
Mavs: 228607
Traf3ip3: 215243"
Figure legend: "F BMDMs from wild type, Traf3ip3-/- and Mavs-/- mice were infected with or without VSV for six hours. Cells were then collected and following subcellular fractionation, S5 fractions were subjected to native PAGE to examine IRF3 dimer, and P5 fractions contained mitochondria were subjected to SDD-AGE to examine MAVS aggregation."
NCBI gene IDs:
"Mavs: 228607
Traf3ip3: 215243"
Figure legend: "Wild type, Traf3ip3-/- and Mavs-/- mice (three littermates per group) were infected intravenously with VSV at a MOI of 2×108. The spleens were collected 4 hours or 8 hours after infection and Ifna4 (A), Ifnb (B), Isg54 (C) and Il6 (D) inductions were measured respectively by qPCR. All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05 and **P&lt;0.01. NS indicates no statistically significant difference."
NCBI gene IDs:
"Isg54: 15958
Ifna4: 15967
Ifnb: 15977
Il6: 16193
Mavs: 228607
Traf3ip3: 215243"
Figure legend: "Wild type, Traf3ip3-/- and Mavs-/- mice (three littermates per group) were infected intravenously with VSV at a MOI of 2×108. The spleens were collected 4 hours or 8 hours after infection and VSV RNA levels were measured by qPCR (E). All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05 and **P&lt;0.01. NS indicates no statistically significant difference."
NCBI gene IDs:
"Mavs: 228607
Traf3ip3: 215243"
Figure legend: "Wild type, Traf3ip3-/- and Mavs-/- mice (three littermates per group) were infected intravenously with VSV at a MOI of 2×108. The sera were collected from the treated mice and used for the measurement of IFNβ production by ELISA (F). All data are presented as the mean values based on three independent experiments, and error bars indicate s.d. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05 and **P&lt;0.01. NS indicates no statistically significant difference."
NCBI gene IDs:
"Mavs: 228607
Traf3ip3: 215243"
Figure legend: "G Wild type, Traf3ip3-/- and Mavs-/- mice (n=6 each) were injected with VSV via tail vein injection at 5×107 pfu per mouse, and the survival rates were monitored for 15 days. P values were determined by unpaired two-tailed Student's t-test. *P&lt;0.05"
NCBI gene IDs:
"Mavs: 228607
Traf3ip3: 215243"
Figure legend: "(C) qPCR  quantification of  ssc-miR-205 and bta-miR-10b miRNAs in murine  (M.m.), porcine (S.s.), and  bovine (B.t.) oocytes, respectively. Shown are a mean values from three independent experiments. Error bars = SD. Detailed information concerning miRNA quantification is provided in the Methods section."
NCBI gene IDs:
"miR-10b: 791051
miR-205: 100316607"
Figure legend: "(A) bta-miR-10b and  ssc-miR-205 miRNAs efficiently repress microinjected NanoLuc luciferase reporters carrying a perfectly complementary (1x perfect) miRNA binding site or four partially complementary (bulged) miRNA binding sites. Error bars = SD. Each data point represents a value obtained from five microinjected oocytes. Data were collected in two microinjection sessions, each microinjection session used a new batch of in vitro transcribed reporter mRNAs. Data information: asterisks indicate statistical significance (p-value) of one-tailed t-test, (*p &lt; 0.05, **p &lt; 0.01, ***p &lt; 0.001)."
NCBI gene IDs:
"Luc: 
miR-10b: 791051
miR-205: 100316607"
Figure legend: "(B) De-repression of predicted  ssc-miR-205 targets. In three independent microinjection experiments, ssc-miR-205  was inhibited by a microinjected antisense oligonucleotide inhibitor and target levels were assessed 24 hours after microinjection by  RT-qPCR. Error bars = SD. Data information: asterisks indicate statistical significance (p-value) of one-tailed t-test, (*p &lt; 0.05, **p &lt; 0.01, ***p &lt; 0.001)."
NCBI gene IDs:
"miR-205: 100316607"
Figure legend: "(C) Inhibition of  ssc-miR-205 by a microinjected antisense oligonucleotide inhibitor results in reduced development to the blastocyst stage. Shown is development of microinjected oocytes to the blastocyst  stage relative to water-injected oocytes. Five independent experiments (represented by individual data points) were performed, ~50 porcine oocytes were microinjected in each group in each experiment. Difference between let-7a and miR-205 inhibitors effects is statistically significant (two-tailed paired t-test p-value = 0.016). Error bars = SD. Data information: asterisks indicate statistical significance (p-value) of one-tailed t-test, (*p &lt; 0.05, **p &lt; 0.01, ***p &lt; 0.001)."
NCBI gene IDs:
"miR-205: 100316607
let-7a: 100498702"
Figure legend: "(A) ssc-miR-205  turnover. Fully-grown transcriptionally quiescent oocytes were cultured for indicated periods of time  and selected miRNAs were quantified by RT-qPCR in four (ssc-let-7a), five (ssc-miR-22) or six (ssc-mir10b and ssc-miR-205) independent experiments. Error bars = SD."
NCBI gene IDs:
"mir10b: 100498711
miR-205: 100316607
miR-22: 100498778
let-7a: 100498702"
Figure legend: "(B) Comparison of mean relative changes of miRNA level at 20 h of culture ssc-miR-205 in oocytes is less than ssc-miR-10b, ssc-miR-22, or ssc-let-7a. Error bars = SD. Asterisks indicate statistical significance (p-value) of one-tailed paired t-test, (*p &lt; 0.05, **p &lt; 0.01)."
NCBI gene IDs:
"miR-10b: 100498711
miR-205: 100316607
miR-22: 100498778
let-7a: 100498702"
Figure legend: "(C) Treatment by sodium periodate followed by qPCR does not support 2'-OH modification of either ssc-miR-205  or  bta-miR-10b miRNA. Shown are relative levels of the  sodium periodate-treated samples to non-treated samples, which were set to one. The experiment was performed three times. Error bars = SD. Efficiency of  periodate treatment was confirmed using non-methylated and methylated miR-221  RNA  oligonucleotides"
NCBI gene IDs:
"miR-221: 
miR-10b: 791051
miR-205: 100316607"
Figure legend: "G, HBMEC were transiently transfected with control siRNA or PI3K p110α siRNA. Cells expressing either control siRNA or PI3K p110α siRNA were challenged with T. gondii 48 h after transfection. Cell lysates were subject to immunoblotting as indicated. Densitometry data are shown as above and represent means ± SEM of 3 experiments. Results shown are representative of 3-4 independent experiments."
NCBI gene IDs:
"PI3K p110α: 5290"
Figure legend: "B, HBMEC were transfected with control siRNA or Akt siRNA. Cells were then challenged with T. gondii 48 h after transfection. Monolayers were examined microscopically 24 h post-challenge."
NCBI gene IDs:
"Akt: 207"
Figure legend: "G, H, mHEVc cells were transfected with Beclin 1 siRNA (G), Atg7 siRNA (H) or control siRNA. After 48 h, cells were treated with or without Akt inhibitor IV for 1 h prior to challenge with T. gondii. Monolayers were examined by light microscopy at 24 h."
NCBI gene IDs:
"Atg7: 74244
Beclin 1: 56208"
Figure legend: "B, HBMEC were transfected with MyD88 siRNA or control siRNA followed by challenge with T gondii after 48 h. Cell lysates were used to examine total Akt and phospho-serine 473 Akt by immunoblot. Results shown are representative of 3 independent experiments."
NCBI gene IDs:
"MyD88: 4615"
Figure legend: "A, mHEVc cells were transfected with control siRNA or EGFR siRNA. Expression of EGFR and actin were assessed by immunoblot 48 h post-transfection. mHEVc cells expressing either control siRNA or EGFR siRNA were challenged with T. gondii. Cell lysates were used to examine the expression total Akt or phospho-Ser473 Akt by immunoblot."
NCBI gene IDs:
"EGFR: 13649"
Figure legend: "B, Mouse microglia were treated with or without AG1478 (1 µM) 1 h prior to challenge with T. gondii. Cell lysates were used to examine the expression total Akt or phospho-Ser473 Akt by immunoblot. Densitometry data represent means ± SEM of 3 experiments. A vertical line was inserted between densitometry data from control siRNA and EGFR siRNA or control and AG1478-treated cells to indicate that band densities from infected control cells or infected cells subjected to EGFR blockade were compared to bands from their respective uninfected cells, which were given an arbitrary number of 1. Results shown are representative of 3 independent experiments."
NCBI gene IDs:
"EGFR: 13649"
Figure legend: "B, Human RPE cells transfected with either EGFR or control siRNA were challenged with T. gondii followed by examination of monolayers by light microscopy at 24 h."
NCBI gene IDs:
"EGFR: 1956"
Figure legend: "D, Parental CHO and CHO-EGFR cells were challenged with RH T. gondii. Monolayers were examined microscopically 2 h or 24 h post-challenge."
NCBI gene IDs:
"EGFR: 100774580"
Figure legend: "G, H, mHEVc cells transfected with Beclin1 siRNA (G) or Atg7 siRNA (H) were transfected with EGFR siRNA or treated with or without AG1478 followed by challenge with T. gondii. Monolayers were examined by light microscopy 24 h post-challenge. Results are shown as the mean ± SEM and are representative of 3 independent experiments."
NCBI gene IDs:
"Atg7: 74244
Beclin1: 56208
EGFR: 13649"
Figure legend: "A, B, C HBMEC were challenged with ΔHx (WT), MIC1 ko, MIC3 ko, MIC1-3 ko T. gondii at MOIs that yielded similar percentages of infected cells (A)."
NCBI gene IDs:
"MIC1: 7896467
MIC3: 7901253"
Figure legend: ". C, hmCD40 mHEVc-LC3-EGFP cells were treated with or without CD154 followed by challenged with WT, MIC1 ko, MIC1 ko+MIC1, MIC3 ko, MIC3 ko+MIC3, MIC1-3 ko, MIC1-3 ko+MIC1-3 tachyzoites. LC3 accumulation around the parasite was examined by fluorescence microscopy 5 h post-challenge. D, hmCD40 mHEVc-LC3-EGFP treated with or without CD154 were challenged with WT, MIC1 ko, MIC1 ko+MIC1, MIC3 ko, MIC3 ko+MIC3, MIC1-3 ko or MIC1-3 ko+MIC1-3 tachyzoites. Parasite load was examined 24 h post-challenge."
NCBI gene IDs:
"MIC1: 7896467
MIC3: 7901253"
Figure legend: "E, HBMEC cells were challenged with WT, MIC1 ko, MIC3 ko, MIC1-3 ko tachyzoites followed by treatment with vehicle or rapamycin. Parasite load was examined 24 h post-challenge. F, HBMEC treated with or without CD154 or IFN-γ/TNF-α were challenged with WT, MIC1 ko, MIC3 ko, MIC1-3 ko tachyzoites. Monolayers were examined microscopically at 24 h post-challenge."
NCBI gene IDs:
"MIC1: 7896467
MIC3: 7901253"
Figure legend: "G, hmCD40 mHEVc cells treated with or without CD154 were infected with either WT or MIC1-3 ko tachyzoites in the presence of complete medium (CM) alone or medium plus MIC3, MIC4, M2AP or MIC6 (all 10 nM). Parasite load was determined microscopically 24 h post challenge. Results shown are representative of 3-4 independent experiments."
NCBI gene IDs:
"MIC1: 7896467"
Figure legend: "Western blot analysis of the recombinant RPB1 expression (rWT, YFFF, and ∆5) assessed by (HA)-tag expression after 24 or 48 hours of α-amanitin treatment following 24h of induction. Untransfected Raji extracts are shown for comparison (WT). Total RPB1 levels are represented by the F12 western blot. Tubulin was used as a loading control."
NCBI gene IDs:
"RPB1: 5430"
Figure legend: "Example of ChrRNA read-through phenotype at the 5' (anti-sense) and 3' (sense) ends in CTD-∆5 at the GBE1 locus."
NCBI gene IDs:
"GBE1: 2632"
Figure legend: "(D) qPCR validation of TH levels in SN samples of PD and controls, normalized to beta-actin mRNA. T-test p*=0.025, Data presented as mean ± SD. n=18 for CT and 24 for PD."
NCBI gene IDs:
"beta-actin: 60
TH: 7054"
Figure legend: "(E) Adar1 expression levels in all tissues. The box is drawn from Q1 to Q3 with a horizontal line drawn in the middle to denote the median and x marks the average. Whiskers mark minimum or maximum values."
NCBI gene IDs:
"Adar1: 103"
Figure legend: "(H) Volcano plot of DE circRNAs in PD vs control tissues, red dots indicate statistically significant DE circRNAs according to FDR correction of Wald test (DEseq2 analysis). CircSLC8A1 is marked is red."
NCBI gene IDs:
"CircSLC8A1: "
Figure legend: "(B, C) CircSLC8A1 and linear SLC8A1 levels in the SN of control and PD brains, T-test p=0.025, p= 0.118 respectively."
NCBI gene IDs:
"CircSLC8A1: 
SLC8A1: 6546"
Figure legend: "(D) qPCR validations of circSLC8A1 and SLC8A1 mRNA changes in the SN, T-test p*=0.025. n=18 for CT and 24 for PD, x defines mean values."
NCBI gene IDs:
"circSLC8A1: 
SLC8A1: 6546"
Figure legend: "(E) no difference in circSLC8A1 levels in females and males, T-test p=0.583 for control and p=0.262 for PD. n=15 females and 16 males. . The box is drawn from Q1 to Q3 with a horizontal line drawn in the middle to denote the median and x marks the average."
NCBI gene IDs:
"circSLC8A1: "
Figure legend: "(F, G) CircSLC8A1 and linear SLC8A1 mRNA levels are correlated in control, R2=0.47 T-test p=0.0017 but not in PD samples, R2= 0.016, p&gt;0.05. n=18 for CT and 23 for PD."
NCBI gene IDs:
"CircSLC8A1: 
SLC8A1: 6546"
Figure legend: "(H) Increased CircSLC8A1 RNA levels in PQ-exposed SH-SY cells (normalized to Tubb3 and RPL19) while other circRNAs remain unchanged"
NCBI gene IDs:
"CircSLC8A1: 
RPL19: 6143
Tubb3: 10381"
Figure legend: "(A) qPCR measurements of circSLC8A1 and SLC8A1 mRNA after SH-SY treatment of statins or the PF LRRK2 inhibitor, T-test p**=0.007 and p**=0.01 for PF-06447475 and p*=0.047 and p=*0.0136 for Statins for cirSLC8A1 and SLC8A1 mRNA respectively"
NCBI gene IDs:
"circSLC8A1: 
cirSLC8A1: 
SLC8A1: 6546"
Figure legend: "(B) qPCR quantification from nuclear/cytoplasmic fractionations of SH-SY cells, T-test p=0.005 for circSLC8A1, p=0.009 for NEAT1 and p=0.009 for Rpl19. n=3 biological replicas for each condition."
NCBI gene IDs:
"circSLC8A1: 
NEAT1: 283131
Rpl19: 6143"
Figure legend: "(C) qPCR quantification of Ago2-bound RNA, immunoprecipitated (IP)/Input values normalized to negative control for a known Ago2 target, circCDR1as and circSLC8A1, T-test p=0.029 for circSLC8A1 and p=0.001 for circCDR1as, n=3 biological replicas for each condition."
NCBI gene IDs:
"circCDR1: 
circSLC8A1: "
Figure legend: "(G) relative expression of known miR-128 targets from SN RNA-seq, p**=0.0004 for BMI1, p*=0.011 for SIRT1 and p*=0.005 for AXIN1."
NCBI gene IDs:
"AXIN1: 8312
BMI1: 648
miR-128: 406916///406915
SIRT1: 23411"
Figure legend: "(H) relative expression of known miR-128 targets in SH-SY cells treated with Paraquat, T-test p*=0.03, p*=0.02 and p*=0.002 for AXIN1, BM1 and SIRT1 respectively, Data presented as mean ± SD with 4-6 biological replicas for each condition."
NCBI gene IDs:
"AXIN1: 8312
BM1: 648
miR-128: 406916///406915
SIRT1: 23411"
Figure legend: "Luciferase-based imaging of drug response in Vegfr3Luc;Tyr:CreERT2;BrafV600E; Ptenflox/flox mice. Panels labeled as \"basal\" and \"induced\" correspond to the bioluminescence of animals prior and 5 weeks after administration of 4OH-tamoxifen (5 mM, topical administration, 3 consecutive days) for the induction of melanomas. (Right panels) Treatment with anti-PD-L1 antibody (αPD-L1; clone 10F.9G2, 3 weeks) or the corresponding control IgG (200 ug/dose, twice per week, 3 weeks); vemurafenib (Vem, 50 mg/Kg, oral once per day, 3 weeks) or BO-110 (BO, 0.8 mg/kg, twice per week, 3 weeks). Scale: p/s/cm2/sr (x106)."
NCBI gene IDs:
"Luc: 
Braf: 109880
Cre: 2777477
Vegfr3: 14257
ERT2: 26417
Pten: 19211"
Figure legend: "Treatment with BO-110 of human patient-derived xenografts (PDX) implanted in Vegfr3Luc nu/nu. 42 days after implantation (when systemic luciferase was detected), animals were randomized for treatment with vehicle (V) or with 0.8 mg/kg BO-110 (BO, twice per week), and luciferase emission was acquired at the indicated  times. Scale, p/s/cm2/sr (x106)."
NCBI gene IDs:
"Luc: 
Vegfr3: 14257"
Figure legend: "qRT-PCR analysis of relative mRNA levels of MDA5 16 h after treatment of HLEC with 0.5 ug/ml  BO-110 (BO), 10 µM vemurafenib  (Vem), or vehicle control (V). Data correspond to the mean ± SD of 3 biological replicates. Statistical significance was determined by t-test.   qRT-PCR analysis of relative mRNA levels of VEGFR3 16 h after treatment of HLEC with 0.5 or 1 ug/ml BO-110 (VO), 10 µM vemurafenib (Vem), or the corresponding vehicle control (V). Data correspond to the mean ± SD of 3 biological replicates. Statistical significance was determined by ANOVA.   "
NCBI gene IDs:
"VEGFR3: 2324
MDA5: 64135"
Figure legend: "Luciferase signal driven by FLT4 (VEGFR3)-promoter transduced into HLEC treated with vehicle (v) or BO-110 (BO) at the indicated doses (ug/ml) as indicated in methods. Results were normalized to vehicle control. N=4 biological replicates. Error bars correspond to mean ± SD. Statistical significance was determined by ANOVA."
NCBI gene IDs:
"Luciferase: 
FLT4: 2324
VEGFR3: 2324"
Figure legend: "Relative mRNA levels of VEGFC  and VEGFD in the indicated melanoma cell lines 8 h after treatment with vehicle (V) or 0.5 µg/ml BO-110 (BO), as determined by qRT-PCR. Data correspond to the mean ± SD of 3 experiments. Statistical significance was determined by t-test."
NCBI gene IDs:
"VEGFC: 7424
VEGFD: 2277"
Figure legend: "Inhibitory effect of the indicated doses of BO-110 (in µg/ml) or vehicle (V) on MDK mRNA  expression  determined by qRT-PCR in SK-Mel-147 (16 h after treatment). Data correspond to average mRNA levels in three experiments with technical replicates normalized to vehicle control ± SD. Statistical significance was determined by ANOVA.   qRT-PCR  analysis of relative mRNA levels of MDA5 16 h after treatment of SK-Mel-147 with the indicated doses of BO-110 (in µg/ml) (BO). Data correspond to the mean ± SD of three experiments with three technical replicates. Statistical significance was determined by ANOVA.   "
NCBI gene IDs:
"MDA5: 64135
MDK: 4192"
Figure legend: "Type I IFN mRNA induction (IFNA2 and IFNB1) in SK-Mel-147 melanoma cells treated for 16 h with the indicated amounts of BO-110 (in mg/ml). Data correspond to the mean ± SD of three experiments with three technical replicates normalized to vehicle control. Statistical significance was determined by ANOVA."
NCBI gene IDs:
"IFNA2: 3440
IFNB1: 3456"
Figure legend: "Heatmap depicting expression changes in interferon-related genes (GO:0034340) in SK-Mel-147 melanoma cells (left panel) and HLEC (right panel) treated with vehicle or 0.5 g/ml of BO-110 for 10 hours.  CD274, LAG3 and PDCD1 genes were also included as a reference."
NCBI gene IDs:
"CD274: 29126
LAG3: 3902
PDCD1: 5133"
Figure legend: "IFNB1  mRNA induction analyzed by qPCR at the indicated times  after BO-110 treatment (0.5 µg/ml) of SK-Mel-147 melanoma cells or HLEC (left and right graphs, respectively). Data correspond to the mean ± SD of three experiments with three technical replicates normalized to vehicle control."
NCBI gene IDs:
"IFNB1: 3456"
Figure legend: "Quantification of the impact of  BO-110 as single agent or in the presence of the indicated blocking antibodies for type I interferon (IFNB1 or IFNAR1). Upper graphs show the effect of these agents on  MDK mRNA levels in SK-Mel-147 melanoma cells. Similar treatments were performed on HLEC for the analysis of VEGFR3  mRNA (middle graphs) and tube formation capacity (lower graphs). Data correspond to the mean ± SD of 3 biological replicates in triplicate."
NCBI gene IDs:
"VEGFR3: 2324
MDK: 4192"
Figure legend: "Growth  of B16 melanoma xenografts in siblings of  Ifnar1+/+, Ifnar1+/- or Ifnar1-/- mice. Treatment started 10 days after tumor cell implantation. BO-110 was administered at 0.8 mg/kg, every third day for 2 weeks. N= 6 mice per condition. Graphs show the mean tumor size ± SD at each time point. Statistical significance was determined by Two-Way ANOVA."
NCBI gene IDs:
"Ifnar1: 15975"
Figure legend: "(C) Western blot  and quantitative analysis for the expression  of TFAM  in HCC  cells with TFAM  stable knockdown and control cells (n = 3 independent experiments). shCtrl, control shRNA; shTFAM, shRNA against TFAM; EV, empty vector; TFAM, expression vector encoding TFAM. Data information: Graphs show mean ± s.e.m., two-tailed unpaired t-test. **P &lt; 0.01."
NCBI gene IDs:
"TFAM: 7019"
Figure legend: "(E) The level of malonylated mDia2. Equal amount of immunoprecipitated mDia2  either from TFAM knockdown or control cells was loaded in Western blot  assay."
NCBI gene IDs:
"TFAM: 7019"
Figure legend: "(B) mRNA level of TFAM  in 50 HCC patients' paired tissues from TCGA database. The relative expression  ratio of tumor to non-tumor was log2-transformed."
NCBI gene IDs:
"TFAM: 7019"
Figure legend: "(E) RNAi of representative Atg genes decreased the LTR fluorescence levels compared with control. (Atg1, P = 0.01; Atg5, P = 0.01; Atg7, P = 0.002; Atg8a, P = 0.008; Atg8b, P = 0.006; and Atg12, P = 0.02)."
NCBI gene IDs:
"Atg1: 39454
Atg12: 39383
Atg5: 31666
Atg7: 37141
Atg8a: 32001
Atg8b: 42132"