EMBO/SourceData huggingface dataset:
Figure legend: "GFP-Parkin stably expressing HeLa cells were treated and then subjected to PLA using antibodies against FLAG and PGAM5. During Stx17 knockdown, cells were transfected with a plasmid encoding FLAG-FUNDC1. Scale bar, 5 μm. Values are means ± SEM (n = 3). *P&lt;0.05 and **P&lt;0.01 as compared with Mock (+CCCP) by paired Student's t-test."
NCBI gene IDs:
"FLAG: 
GFP: 
FUNDC1: 139341
Parkin: 5071
Stx17: 55014"
Figure legend: "A PGAM5 overexpression partially rescues the mitochondrial defects by Stx17 loss. Transmission electron microscope images of the indirect flight muscle in the indicated genotypes (a, Control; b, Stx17-/-; c, Stx17-/- and Stx17 overexpression; d, Stx17-/- and PGAM5 overexpression) of 7-day-old adult flies are shown. The bar graph on the right shows frequency of healthy and abnormal mitochondria presented as percentages (mean ± SEM) using the scoring system : Class 0, normal; Class 1, fuzzy or dilated cristae; Class 2, fragmented cristae and loss of electron density. *p &lt; 0.05, #p &lt; 0.001 vs. the same class of control (Dunnett's test). n = 50-119 mitochondria from three or four independent samples. Genotypes used were: +/y; Act5c-GAL4/+ (a), +/y; Act5c-GAL4/+; Stx17LL06330/Stx17LL06330 (b), +/y; Act5c-GAL4/UAS-FLAG-Stx17; Stx17LL06330/Stx17LL06330 (c), +/y; Act5c-GAL4/UAS-PGAM5; Stx17LL06330/Stx17LL06330 (d). Scale bars, 200 nm."
NCBI gene IDs:
"FLAG: 
Act5c: 31521
GAL4: 855828
PGAM5: 31143
Stx17: 38541"
Figure legend: "B Simultaneous reduction of Stx17 and PGAM5 results in mitochondrial degeneration. a, Stx17+/-; b, PGAM5-/-; c, Stx17+/-, PGAM5-/-. The bar graph on the right represents the mitochondrial phenotypes classified p &lt; 0.05, **p &lt; 0.01 vs. the same class of Stx17+/- (Dunnett's test). n = 62-195 mitochondria from three independent samples. Scale bars = 1 µm. Genotypes used were: +/y; Act5c-GAL4/+; Stx17LL06330/+ (a), PGAM51/y; Act5c-GAL4/+ (b), PGAM51/y; Act5c-GAL4/UAS-Stx17-FLAG; Stx17LL06330/+ (c)."
NCBI gene IDs:
"FLAG: 
Act5c: 31521
GAL4: 855828
PGAM5: 31143
Stx17: 38541"
Figure legend: "B. Left, representative images of Western blot for ARID1A expression in lysates extracted from the cortex of Arid1afl/+(WT), cHet, and cKO mice using the indicated antibodies. Right, quantification of protein levels normalized to β-actin (n = 3 mice per group)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "C. Left, representative images of Western blot for ARID1A expression in lysates extracted from the hippocampi of Arid1afl/+, cHet, and cKO mice. Right, quantification of protein levels which were normalized to β-actin (n = 4 mice per group)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "D. Immunostaining against ARID1A (red) in the dentate gyrus (DG), cortex, CA1, and CA3 regions of Arid1afl/+and cHet mice."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "E. cHet mice spent more time reaching the platform during 5-day training in Morris water maze assay compared to the control group mice. Arid1afl/+ (n = 15 mice), cHet (n = 13 mice)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "F. In the probe trial, cHet mice displayed spatial learning disabilities compared with Arid1afl/+ mice. Arid1afl/+ (n = 15 mice), cHet (n = 13 mice)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "G. cHet mice undertook fewer platform crossings than Arid1afl/+ mice in the Morris water maze assay. Arid1afl/+ (n = 15 mice), cHet (n = 13 mice)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "H-J. cHet mice were evaluated using the Barnes maze test. During the training phase, the cHet mice (n = 12 mice) failed to diminish the latency of the first entrance to the hiding box (H), indicating that Arid1a haploinsufficiency results in impaired spatial memory. Probe trials demonstrated that cHet mice also had spatial memory deficits (I), as they visited the target hole less often than the Arid1afl/+ mice (n = 12 mice) (J)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "A. Representative traces of spontaneous miniature excitatory postsynaptic currents (mEPSCs) in CA1 hippocampal acute slices from Arid1afl/+ and cHet mice. B. Quantification of amplitude (B, left) and frequency (B, right) spontaneous miniature excitatory postsynaptic currents (mEPSCs) in Arid1afl/+ and cHet hippocampal CA1 neurons. Arid1afl/+ (17 neurons from n =3 mice) and cHet (15 neurons from n = 4 mice)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "C. Representative recording of the paired-pulse ratio at the 50-ms interpulse interval ms from slices prepared from Arid1afl/+ (n = 4) and cHet (n = 4) mice. D. Paired-pulse facilitation (PPF) studies across different interpulse intervals (20 ms, 40 ms, 50 ms, 100 ms, 200 ms, 300ms, and 500 ms) revealed a significant difference in paired-pulse ratios at 50-ms intervals."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "E. Summary plots showing the time course of long-term potentiation (LTP) induced by frequency stimulation in the CA1 region from Arid1afl/+or cHet mice. Field excitatory postsynaptic potential (fEPSP) traces before (black) and after (black or red) are shown in the inset above. F. Average amplitude of LTP measured at 55-60 min postinduction (n = 8 slices from 4 mice per group; 10 fEPSP slope (%) values were collected from 1 slice)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "G. Representative Western blot images for the expression of several LTP-related proteins in the Arid1afl/+ and cHet hippocampi. H. Quantification of the expression of each protein normalized to the β-actin level."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "A. Golgi-stained coronal section in the hippocampal CA1 region of 2-month-old Arid1afl/+ and cHet mice. Scale bar, 100µm. B-D. Partial loss of Arid1a significantly decreased dendritic length (B), dendritic nodes (C), and dendritic ends (D) in cHet neurons. E"
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "A. Left, Western blot analysis of H3K27ac in forebrain tissues of Arid1afl/+and cHet mice. Right, relative quantitation of the intensity of H3K27ac normalized to the H3 level (n=3 mice per group)."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "D. Immunofluorescence (IF) staining of H3K27ac(green) and Vgult1(red) in forebrain tissues of Arid1afl/+ and cHet mice, respectively. IF staining was performed on 40-μm thick floating sections. Relative fluorescence intensities of H3K27ac decreased upon the haploinsufficiency of Arid1a in the cortex. Scale Bar, 20μm. Arid1afl/+ (n = 7) and cHet (n = 4) mice."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "F-H. Morris water maze test of Arid1afl/+ and cHet mice treated with vehicle or acetate. Acquisition task, the latency to find the platform was used to assess learning ability. Latency to the platform was measured during training trials (F). Latency to the platform was measured during probe test (G). (H) Retention task, the times in the target crossings were used to assess memory retention. The times in the target crossings were measured in probe tests, n = 10-15 mice per group."
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "I-K. Barnes maze test of Arid1afl/+ and cHet mice treated with vehicle or acetate. (I) During the training phase, the time to find the target in Arid1afl/+ and cHet mice that were treated with vehicle or acetate for 28 days. (J) In probe test trials, the time of latency to the platform to find the target in Arid1afl/+ and cHet mice treated with vehicle or acetate. (K) In probe trials, the numbers of target crossings of Arid1afl/+ and cHet mice treated with vehicle or acetate (n = 12 mice)"
NCBI gene IDs:
"Arid1a: 93760"
Figure legend: "A. Representative image of vehicle- and acetate-treated neurons derived from WT or ARID1A KO hESCs on day 40 of neural differentiation Scale Bar, 20μm B. Quantification of total neurite length of hESC-derived neurons after treatment with acetate or vehicle. n = at least 34 neurons for each group from 3 independent experiments. C"
NCBI gene IDs:
"ARID1A: 8289"
Figure legend: "D. Representative images of dendrites (MAP2, green) showing localization of foci of the pre- and postsynaptic protein complexes, synaptophysin (red), and PSD-95 (white) protein in control, acetate treatment of WT and ARID1A KO hESC-derived neurons on day 55 of neural differentiation. Scale Bar, 5μm."
NCBI gene IDs:
"ARID1A: 8289"
Figure legend: "(C) day 20±2 cerebral organoids derived from controls, patients and  EML1-heKOs stained  for the  neuronal marker  MAPT and the adherens junction marker  NCAD, counterstained  with  DAPI. Ectopic   neural rosettes and neuronal  heterotopia  are highlighted with dotted yellow lines. (D) Quantification of VZ areas with ectopic neural rosettes (3 batches, 3  organoids analyzed per batch, significance based on Kruskal-Wallis-test, P=0.0001, Dunn's post hoc test for multiple comparisons performed to define statistical differences between genotypes, single data points are presented colored by batch). (E) Quantification of heterotopic, disorganized  or organized cortical areas (3 batches, 3 organoids per batch, significance based on Kruskal-Wallis-test, P=0.0001 for \"organized\" and \"heterotopic\"; no significant difference for \"disorganized\", Dunn's post hoc test performed for multiple comparisons to define statistical differences between genotypes). Data information: * marks statistical significance in relation to Control 1, # in relation to Control 2. P-values: ***/###&lt;0.001. VZ:  ventricular zone; Data in graphs are represented as means ± SD. Scale bars: 50µm."
NCBI gene IDs:
"EML1: 2009"
Figure legend: "(A) Hybrid   organoids  generated from controls mixed with control-EGFP+ or EML1-heKO-EGFP+ cells (day 20±2). Yellow dotted lines indicate  VZ  areas. (B) Quantification of control-EGFP+ or  EML1-heKO-EGFP+ cells within or at the basal side of VZ  areas (3 batches, 3 organoids  each, significance based on Mann Whitney test, ***P= 0.0001 for \"EGFP+ cells at the  basal side of  VZ  areas\"). Data information: Data in graphs are represented as means ± SD. Scale bars: (A) 50µm"
NCBI gene IDs:
"EGFP: 
EML1: 2009"
Figure legend: "(C) Representative images and scheme of cleavage plan orientation. Upper panel: cells immunostained for pVim (red) and  TPX2 (green), counterstained with DAPI, white dotted line indicates cleavage plane orientation, yellow dotted line VZ-surface. (D) Quantification of horizontal, vertical and  oblique plane of cell divisions in control and  EML1-deficient   organoids   (day 20±2; 3 batches, 3 organoids each). Data information: Scale bars: 5µm"
NCBI gene IDs:
"EML1: 2009"
Figure legend: "(F)  Electron microscopy  of  primary cilia derived from control or EML1-deficient  cortical progenitors  in DMSO-control or following EpothiloneD (EpoD) exposure (blue arrow: basal body, yellow arrow: appendages, red arrow:  ciliary pockets). Data information: Scale bars: 0,5µm."
NCBI gene IDs:
"EML1: 2009"
Figure legend: "(E) Control and EML1-heKO-derived cerebral organoid stained  for COL1A2  and MEIS2. VZ  areas are encircled, squares indicate areas enlarged in F. (F) Control and EML1-heKO-derived cerebral organoid stained for COL1A2, MEIS2  and MAPT. (G) Representative images showing EGFP-control and EGFP-EML1-heKO hybrid cerebral organoid stained  for EGFP, FAM107A  and NCAD. Yellow dotted lines indicate  morphology of EGFP+ cells (4 independent batches each, 3 organoids  per batch, at least 30 ectopic  rosettes in total). Data information: Scale bars: (E) 50µm; (F) 10µm; (G) 50µm, enlarged 10µm."
NCBI gene IDs:
"EGFP: 
EML1: 2009"
Figure legend: "(D, E) Immunofluorescence staining for (D) p-VIM and  YAP1  or (E) Pax6 and  YAP1 in control and EML1-heKO-derived  organoids (day 20±2, squares indicate areas enlarged in adjacent part of the panel respectively). (F) Quantification of basally located pVim+ cells with  nuclear YAP1  signal per VZ  area in control and EML1-heKO-derived  organoids (3 batches, 3 organoids  analyzed per batch). (G) Quantification of PAX6+ cells with nuclear YAP1 signal per VZ  area in control and EML1-heKO-derived organoids (3 batches, 3 organoids analyzed per batch). Data information: Data in graphs are represented as means ± SD. Significance based on Kruskal-Wallis-test Dunn's post hoc test for multiple comparisons were performed to define statistical differences between genotypes. P-values: ***&lt;0.001, **&lt;0.01, *&lt;0.05. Scale bars: (D and E) 50µm, enlarged 10µm"
NCBI gene IDs:
"EML1: 2009"
Figure legend: "(H) Immunofluorescence staining for p-Vim  in EML1-heKO and control derived  organoids in DMSO,  Verteporfin  or Fluvastatin treated conditions, counterstained with DAPI. Dotted line indicates VZ  areas. (I) Quantification of p-VIM+ cells located at the basal side  of  VZ  areas in control or EML1-heKO-derived organoids under DMSO, Verteporfin or Fluvastatin treated condition (3 batches, 3 organoids  analyzed per batch). Data information: Data in graphs are represented as means ± SD. Significance based on two-way ANOVA (on log10 normalized data) Tukey post hoc test for multiple comparisons were performed to define statistical differences between genotypes. P-values: ***&lt;0.001, **&lt;0.01, *&lt;0.05. Scale bars: (H) 50µm"
NCBI gene IDs:
"EML1: 2009"
Figure legend: "A The expression  of LINC00839   in CRC  tissues and normal mucosa  tissues in the UALCAN database. B, C, D The expression  of LINC00839  in unpaired CRC  and normal samples in the LnCAR database (GSE37364, GSE71187, and GSE33113). Data information: In A, B, C, D middle lines represent the median, and the upper and lower lines represent the upper and lower quartiles. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "E, F The expression  levels of LINC00839  in tumour tissues and NATs from the CRC  cohort (n = 45). nmCRC denotes CRC patients without metastases, and mCRC denotes CRC patients  with metastases. Data information: In E, F, the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "G Representative ISH staining  of LINC00839  in paraffin-embedded samples of CRC  tumour tissues and NATs. (a) Expression  of LINC00839  in tumour tissues and NATs. Scale bars, 100 μm. (b) Magnification of normal mucosal  area and (c) magnification of the tumour area. Scale bars, 50 μm. (d) Weakly positive staining  of LINC00839  in normal mucosa. Scale bars, 50 μm. (e) Strong positive staining  of LINC00839  in tumours and (f) magnification of the local area. Scale bars, 100 μm."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "I Differential expression  of LINC00839  in nonmetastatic CRC patients  (nmCRC) and metastatic CRC patients  (mCRC). Data information: In I, the data are shown as the mean ± SD and were analysed by Student's t test. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "J Expression  of LINC00839  in CRC patients  with early-stage (stage I  and II) and advanced-stage (stage III  and IV) disease. Data information: In J, middle lines represent the median, and the upper and lower lines represent the upper and lower quartiles. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "C Colony formation assay was performed with LINC00839-overexpressing cells and vector control cells. , the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 biological replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.000"
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "D Wound-healing assay was performed with LINC00839-overexpressing cells and vector control cells. Scale bars, 100 μm. , the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 biological replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.000"
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "E Matrigel invasion assay was performed with LINC00839-overexpressing cells. Scale bars, 100 μm. , the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 biological replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.000"
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "F The CDX model showing the effect of LINC00839  on tumour growth. Representative image of tumours harvested from the mouse  model (upper panel), the quantitative analysis of  tumour weight and tumour volume (medium panel), and representative images and quantification of IHC staining  of Ki-67 in tumours (bottom panel) (n = 6 for each cohort, and the results are presented as the mean ± SD, Student's t test (medium left and low right panel) and ANOVA (medium right). Scale bars, 100 μm (n = 6 biological replicates . Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.000"
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: ". G The CRC  orthotopic mouse  model revealed the effect of LINC00839  on tumour development. Representative images of primary tumours (yellow arrowheads) and liver metastasis  (blue arrowheads) in the model (upper panel), analysis of tumour volume and the number of mice  with liver metastasis   (medium panel), and H&amp;E staining  of tumours and metastases  (n = 6 for each cohort). Scale bars, 100 μm (n = 6 biological replicates . Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.000"
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "A An  RNA pull-down assay was performed to identify proteins that bind  to LINC00839  in HCT116  cells."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "B RNA pull-down assay  and WB  showed that biotinylated LINC00839  can bind  to Ruvb1  in HCT116  cells. Dot blot  of RNA-protein interactions indicating equal amounts of RNA used in the assay."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "C RIP  experiments were performed to confirm the binding  of LINC00839  to Ruvb1. IgG was used as a negative control antibody. Primers specific for U6  and GAPDH  were used as negative control primers. Data information: In C, the data are presented as the mean ± SD and were analysed by unpaired t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"GAPDH: 2597
LINC00839: 84856
U6: 26827"
Figure legend: "D Different fragments of LINC00839  (solid line) and its antisense sequence (dotted line) were used for the RNA pull-down assay  and the subsequent WB."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "E Full length LINC00839, antisense sequence of LINC00839, and LINC00839  sequence lacking nucleotides 1033-1290 were used for the RNA pull-down assay  and the subsequent WB."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "G The effect of LINC00839  on the expression of Tip60  and Ruvb1  was determined by WB."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "I The interaction  between Ruvb1  and Tip60  in cells overexpressing wild-type LINC00839  and LINC-Δ5 was confirmed by Co-IP."
NCBI gene IDs:
"LINC: 84856
LINC00839: 84856"
Figure legend: "J The interaction  between Ruvb1 and Tip60  in LINC00839-KD cells and cells expressing LINC-Δ5 was confirmed by Co-IP."
NCBI gene IDs:
"LINC: 84856
LINC00839: 84856"
Figure legend: "K Acetylase activity assays were performed with LINC00839-overexpressing and LINC00839-knockdown cells. Data information: In the data are presented as the mean ± SD and were analysed by unpaired t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "D, E The ATP  levels and the NAD/NADH   ratio were measured in LINC00839-overexpressing and LINC00839-KD cells (mean ± SD, Student's t test, n = 3 biological replicates). Data information: Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "F Expression of MT-ND5, MT-CYB, MT-CO1, and TFAM  in LINC00839-overexpressing and LINC00839-KD cells as determined by WB."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "G Analysis of NRF1 expression  in CRC  tissues (T) and normal tissues (N) the GEPIA database. Data information: In G, the middle lines represent the median, and the upper and lower lines represent the upper and lower quartiles; the data were analysed by ANOVA. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05"
NCBI gene IDs:
"NRF1: 4899"
Figure legend: "H Correlation analysis of LINC00839  and NRF1  mRNA levels in the TCGA and GTEx databases (Pearson)."
NCBI gene IDs:
"LINC00839: 84856
NRF1: 4899"
Figure legend: "I, Expression of NRF1  in LINC00839-overexpressin and LINC00839-KD cells was measured by qPCR  Data information: In I, the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856
NRF1: 4899"
Figure legend: "J Expression of NRF1  in LINC00839-overexpressin and LINC00839-KD cells was measured by WB."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "K, L The enrichment of the NRF1  promoter (P1-P10) by H4K5ac and H4K8ac antibodies in LINC00839-overexpressing and control LoVo  cells as determined by CHIP  assay. Normal IgG was used as a negative control. Data information: In K, L, , the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856
NRF1: 4899"
Figure legend: "O The enrichment of NRF1  with a probe targeting LINC00839  relative to a NC probe in HCT116  cells, as determined by ChIRP assay. LacZ  served as a negative control (NC). Data information: In O, the data are presented as the mean ± SD and were analysed by Student's t test, n = 3 technical replicates. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LacZ: 945006
LINC00839: 84856
NRF1: 4899"
Figure legend: "F ISH staining  of LINC00839  and IHC staining  of NRF1, H4K5ac, and H4K8ac in paraffin-embedded samples of CRC  tumour tissues and NATs. Scale bars, 200 μm."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "G, H, Correlation analysis of the expression  of LINC00839     and NRF1  (G), H4K5ac (H) in CRC patients   (n = 120). Data information: In G, H show the Pearson correlation coefficient results. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"
Figure legend: "I Correlation analysis of the expression    of LINC00839   and H4K8ac (I) in CRC patients  (n = 120). Data information: In I show the Pearson correlation coefficient results. Across experiments, the P values are as follows: ns = not significant, *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, ****P &lt; 0.0001."
NCBI gene IDs:
"LINC00839: 84856"