EMBO/SourceData huggingface dataset:
Figure legend: "A) In vitro phagocytosis of  FAM-Aβ1-42 by wild type or PD-1-/- microglia  for up to 6 h (mean +/-SEM of a technical quadruplicate, Student's t-test, ** p&lt;0.01, *** p&lt;0.001, representative result of an n=2 biological replicate). B) In vitro phagocytosis  of FAM-Aβ1-42 by wild type  microglia cultured in astrocyte-conditioned medium (ACM) from wild type or PD-L1-/- astroglial cultures (mean +/-SEM of a technical quadruplicate, Student's t-test, * p&lt;0.05, *** p&lt;0.001, representative result of an n=2 biological replicate) "
NCBI gene IDs:
"PD-L1: 60533
PD-1: 18566"
Figure legend: "D) Quantification of microglial in vivo phagocytosis  in female  APP/PS1  and APP/PS1 PD-1-/- mice at 8.5 month of age after intraperitoneal injection of methoxy-XO4 (biological replicates with n=5 for APP/PS1 and n=4 for APP/PS1 PD-1-/- mice, Student's t-test (t = 2.1808, df = 6.9829), * p&lt;0.05). Data information: central bands represent median, boxes show interquartile range (IQR) and whiskers define the +/-1.5xIQR."
NCBI gene IDs:
"APP: 11820
PD-1: 18566
PS1: 19164"
Figure legend: "E-G) Relative expression of the cell surface marker (E) CD36 (biological replicates with n=5 for APP/PS1 and n=4 for APP/PS1 PD-1-/- mice, ANOVA (DF=1, F= 0.002, p=0.94), Tukey's HSD, * p&lt;0.05, *** p&lt;0.001), (F) CD11b (biological replicates with n=5 for APP/PS1 and n=4 for APP/PS1 PD-1-/- mice) and (G) CD45 on methoxy-XO4+ versus methoxy-XO4- microglia in APP/PS1  and APP/PS1 PD-1-/- mice normalized to methoxy-X04-negative cells from  APP/PS1 mice (biological replicates with n=5 for  APP/PS1 and n=4 for APP/PS1 PD-1-/- mice) Data information: central bands represent median, boxes show interquartile range (IQR) and whiskers define the +/-1.5xIQR."
NCBI gene IDs:
"APP: 11820
PD-1: 18566
PS1: 19164"
Figure legend: "B) Different expression of inflammasome-related genes (abs(fold change) &gt; 1.5, p &lt; 0.05, Benjamini- Hochberg adjusted) in PD-1-/- vs. wild type microglia. C) Different expression of complement system-related genes (abs(fold change) &gt; 1.5, p &lt; 0.05, Benjamini-Hochberg adjusted) in PD-1-/- vs. wild type microglia. "
NCBI gene IDs:
"PD-1: 18566"
Figure legend: "(F) Volcano plot showing the expression levels of BRAFi-resistant genes (identified in 501Mel by CRISPR-SAM screen) in 12 human melanoma cell lines. The fold change corresponds to the ratio of expression levels found in resistant and sensitive cell lines. In red: selected genes. EGFR is considered as positive control and SMAD3, BIRC3 and SLC9A5; selected as favorite genes for the next steps. SMAD3, BIRC3, SLC9A5 and AFAP1 are BRAFi-resistance genes and potent tumor-promoting genes (BRAFi for PBV"
NCBI gene IDs:
"AFAP1: 60312
BIRC3: 330
EGFR: 1956
SLC9A5: 6553
SMAD3: 4088"
Figure legend: "(G) SMAD3 depletion (siRNA#1 &amp; #2) decreased cell density and increased BRAFi effect (vemurafenib) on BRAFi-resistant cells (SKMel28R). CTR for non-targeting siRNA. DMSO for dimethylsulfoxide (solvent of vemurafenib; BRAFi). n=3 biologically independent experiments. Each histogram represents the mean + s.d. (H) SMAD3 depletion (siRNA#1 &amp; #2) decreased cell density and increased BRAFi effect (vemurafenib, BRAFi) on BRAFi-resistant cells (Me1402). CTR for non-targeting siRNA. DMSO for dimethylsulfoxide (solvent of vemurafenib). n=3 biologically independent experiments. Each histogram represents the mean + s.d."
NCBI gene IDs:
"SMAD3: 4088"
Figure legend: "(B) AhR activation by exogenous and endogenous ligands promotes SMAD3 induction. 501Mel cells AhR wild-type or knock-out have been exposed to exogenous and endogenous AhR ligands; TCDD (5nM) or ITE (10µM) or the solvent (DMSO) during 10 days. n=5 biologically independent experiments for AhR WT cells and n=3 for AhR KO cells. Each histogram represents the mean + s.d. (C) AhR activation by exogenous and endogenous AhR ligands promotes TIPARP induction. 501Mel cells have been treated as described in B. n=5 biologically independent experiments for AhR WT cells and n=3 for AhR KO cells. Each histogram represents the mean + s.d.;"
NCBI gene IDs:
"AhR: 196
SMAD3: 4088
TIPARP: 25976"
Figure legend: "(E) Loss of AhR reduces SMAD3 expression levels. SMAD3 expression has been investigated in SKMel28 cells AhR wild-type (WT) or knock-out (KO). SKMel28R, have been obtained from SKMel28S by chronic exposure to non-lethal doses of BRAFi R for BRAFi-resistant SKMel28 cells and S for sensitive."
NCBI gene IDs:
"AhR: 196
SMAD3: 4088"
Figure legend: "(E) Heatmap depicting mRNA levels of SMAD3-signature in BRAF(V600E) non-treated melanoma patients (dataset from TCGA; SKCM, BRAF(V600E) mutated: n=118). Three pigmentation genes (MITF, MLANA and TYR) have been added to highlight the differentiation states of tumors. ~20% of tumors are considered as dedifferentiated tumors (red box) with a high SMAD3-signature."
NCBI gene IDs:
"BRAF: 673
MITF: 4286
MLANA: 2315
SMAD3: 4088
TYR: 7299"
Figure legend: "(H) SMAD3 depletion decreases expression of SMAD3-regulated genes. SMAD3 knock-down by siRNA decreased mRNA expression of BRAFi-resistance genes in SKMel28R and Me1402. NRP1 mRNA was not detected in our experimental conditions."
NCBI gene IDs:
"NRP1: 8829
SMAD3: 4088"
Figure legend: "(a) Relative quantification (RQ) of CG7630 transcript after RNAi with a 120-bp inverted-repeat sequence (act5c-gal4&gt;UAS-CG7630RNAi) compared to control (act5c-gal4&gt;+)."
NCBI gene IDs:
"act5c: 31521
CG7630: 50266
gal4: 855828"
Figure legend: "(b) Relative percentage of egg to adult viability of CG7630 RNAi cross (act5c-gal4/CyO.GFP x UAS-CG7630RNAi) and control cross (act5c-gal4/CyO.GFP x w1118), calculated at three developmental stages (eggs, pupae and adults), (n &gt; 250, Chi-square test 9.920 df(2), **p = 0.007)."
NCBI gene IDs:
"GFP: 
act5c: 31521
CG7630: 50266
gal4: 855828
CyO: 34350"
Figure legend: "(d) Kinetic enzyme activity of individual MRC complexes in CG7630 RNAi and control individuals normalized by citrate synthase (CS) activity."
NCBI gene IDs:
"CG7630: 50266"
Figure legend: "(e) In gel-activity assays for MRC complexes II and IV in DDM-solubilized mitochondria from RNAi (act5c-gal4&gt;UAS-CG7630RNAi) and control larvae (act5c-gal4&gt;+)."
NCBI gene IDs:
"act5c: 31521
CG7630: 50266
gal4: 855828"
Figure legend: "(f) BN-PAGE, Western blot immunodetection of MRC complexes from CG7630 RNAi (act5c-gal4&gt;UAS-CG7630RNAi) and control (act5c-gal4&gt;+) larvae using antibodies against specific subunits: anti-UQCRC2 (complex III), anti-NDUFS3 (complex I), anti-COX4 (complex IV) and anti-SDHA (complex II)."
NCBI gene IDs:
"act5c: 31521
CG7630: 50266
gal4: 855828"
Figure legend: "(g) Western blot analysis of steady state levels (SDS-PAGE) of MRC subunits COX4 (complex IV), SDHA (complex II) and UQCR-C2 (complex III) in whole lysates from CG7630 RNAi (act5c-gal4&gt;UAS-CG7630RNAi) and control (act5c-gal4&gt;+) larvae."
NCBI gene IDs:
"act5c: 31521
CG7630: 50266
gal4: 855828"
Figure legend: "(h) Western blot analysis of anti-HA affinity purified samples from S2R+ D. melanogaster cells. EV = samples from cells carrying the empty expression vector. CG7630-HA = samples from cells expressing HA-tagged CG7630. Tot = total mitochondrial-enriched fractions; unb = unbound material; IP:HA = immunoprecipitated material. Samples were probed with antibodies against MRC subunits of complexes I (NDUFS3), II (SDHA), III (UQCR-C2), IV (COX4) and V (ATP5A)."
NCBI gene IDs:
"HA: 
CG7630: 50266"
Figure legend: "(a) Relative quantification (RQ) of CG7630 transcript in wild-type D. melanogaster S2R+ cells treated with a dsRNA targeting CG7630 (CG7630 KD) and a mock control dsRNA (mock)."
NCBI gene IDs:
"CG7630: 50266"
Figure legend: "(b) Relative quantification (RQ) of CG7630 and COX7B transcripts in stable S2R+ cell lines carrying the empty expression vector (EV:GFP;neo), and expression vectors carrying HA-tagged forms of human COX7B (hCOX7B-HA;neo) and CG7630 (CG7630-HA;neo). Cells were treated with a dsRNA targeting CG7630 (striped bars, CG7630 KD) and a mock control dsRNA (solid bars, mock). N/D = not detected."
NCBI gene IDs:
"GFP: 
HA: 
CG7630: 50266
COX7B: 1349"
Figure legend: "(c) Immunoblot analysis of stable S2R+ cell lines carrying the empty expression vector (EV:GFP;neo), and expression vectors carrying HA-tagged forms of human COX7B (hCOX7B-HA;neo) and CG7630 (CG7630-HA;neo). The CG7630 transcript was knocked-down (KD) in cells by a dsRNA targeting CG7630 and compared with cells treated with a mock control dsRNA (mock). Samples were probed with an antibody anti HA tag and with an antibody against Hsp70 as an endogenous control."
NCBI gene IDs:
"GFP: 
HA: 
CG7630: 50266
COX7B: 1349"
Figure legend: "(d) Kinetic enzyme activity of COX normalized by citrate synthase activity (CS) in stable S2R+ cell lines carrying the empty expression vector (EV:GFP;neo), and expression vectors carrying HA-tagged forms of human COX7B (hCOX7B-HA;neo) and CG7630 (CG7630-HA;neo). Cells were treated with a dsRNA targeting CG7630 (striped bars, CG7630 KD) and a mock control dsRNA (solid bars, mock)."
NCBI gene IDs:
"GFP: 
HA: 
CG7630: 50266
COX7B: 1349"
Figure legend: "A Ccno mRNA is expressed in the embryonic node at E8 as shown by in situ hybridization. Occasionally, additional expression is observed at the posterior tip of the embryo (asterisk). Double labelling by staining for LacZ expression from the CcnoTA allele (shown in B) and in situ hybridization for Dand5, marking crown cells at the circumference of the node. Ccno expression is restricted to ciliated, ventral pit cells of the node as detailed in the transverse section at the indicated plane."
NCBI gene IDs:
"LacZ: 
Ccno: 218630
Dand5: 23863"
Figure legend: "C Whole embryo X‐Gal staining of E16 CcnoTA/+ and wild‐type control embryos and indicated section planes of (D-F')."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "D-F' Histological sections of LacZ‐stained CcnoTA/+ embryo at E16 reveal Ccno expression in the epithelium of (D) plexus choroideus and ependyme, (E) snout epithelium, and (F, F') trachea and bronchi. pc, plexus choroideus; se, snout epithelium; tr, trachea; and br, bronchus."
NCBI gene IDs:
"LacZ: 
Ccno: 218630"
Figure legend: "A Ccno‐deficient mice develop severe hydrocephalus resulting in characteristic head deformation at P21 (arrow)."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "F, F' Scanning electron microscopy (SEM) of P21 adult trachea shows reduced numbers of cilia of Ccno‐deficient MCCs. Remaining cilia are found in the central regions of the cell surface, and cell margins frequently lack the ciliary decoration (arrows)."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "G Transmission electron microscopy (TEM) of wild‐type and CcnoRA/RA MCCs from adult trachea. Ccno‐deficient MCCs show reduced numbers of basal bodies and cilia that correctly docked to the apical cell surface (arrows). Ectopic electron‐dense material is found within the cytoplasm of Ccno‐deficient MCCs (arrowheads)."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "A-H X‐Gal‐staining of (A-C) control and (D-H) CcnoTA/+ embryonic lungs at indicated stages showing onset of Ccno expression from E13 in the proximal trachea and in the main bronchi. Expression is extending to more distal regions, and from E16 staining is also found in bronchioli.I X‐Gal‐staining indicating LacZ expression from the CcnoTA/+ allele in mTEC cultures after 5 days of differentiation‐onset by switching to air-liquid interface (ALI) conditions (ALI d5)."
NCBI gene IDs:
"LacZ: 
Ccno: 218630"
Figure legend: "J Transcript levels of Ccno and indicated genes with known functions for the generation of multiple cilia during mTEC differentiation. mRNA levels from three independent experiments were measured by qRT-PCR and levels of expression set as 1 on day 0 of ALI cultures. Scales for Ccno and Deup1 are indicated on the left, and for Cep152, Cep63 and Ift57 on the right side."
NCBI gene IDs:
"Deup1: 234964
Ccno: 218630
Cep152: 99100
Cep63: 28135
Ift57: 73916"
Figure legend: "K Relative mRNA expression levels for indicated genes were measured by qRT-PCR in wild‐type and Ccno‐deficient mTEC cultures at indicated days after differentiation‐onset. Relative values were calculated as in (J) relative to day 0 of ALI cultures."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "A-B' SEM of tracheae from (A, A') wild‐type and (B, B') CcnoRA/RA embryos at E17. In comparison to wild‐type MCCs, Ccno‐deficient MCCs almost completely lack formation of multiple cilia and only single, or doublet (arrow) cilia are observed at E17."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "C-E The lack of multiple cilia at E17 stages is reflected by the almost complete absence of acetylated α‐tubulin staining as marker for axonemes in (D) Ccno‐deficient MCCs of E17 embryonic trachea as quantified in (E). FOV, field of view."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "F-I TEM of MCCs from E17 embryonic tracheae shows deuterosomes with forming procentrioles in (F, F', H) Ccno‐proficient and (G, G', I) Ccno‐deficient MCCs. Asterisks in (F, G) indicate microvilli that extend from the apical cell surface. (F', G') Deuterosomes in Ccno‐deficient MCCs are significantly enlarged (identical size bars in F' and G') and show irregular morphology, which is different to the annular shape of wild‐type deuterosomes as seen in (F', H). Procentrioles (arrowheads in F' and I) that are found at deuterosomes of (I) Ccno‐deficient MCCs were recurrently found being shorter and appeared less structured in comparison to (F', H) wild‐type cells."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "J The average length of procentrioles was quantified for wild‐type and Ccno‐deficient MCCs of E17 tracheae (49 procentrioles in n = 3 independent samples for wild‐types and 47 procentrioles in n = 3 independent samples for Ccno‐deficient MCCs).K The diameter of deuterosomes (41 deuterosomes in n = 3 independent samples for wild‐types; 38 deuterosomes in n = 5 independent samples for Ccno‐deficient MCCs) was measured in wild‐type and Ccno‐deficient MCCs of E17 tracheae."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "Double IF analysis of mTEC cultures at early stage of MCC differentiation and centriole amplification (ALI day 3) using antibodies for the deuterosome protein DEUP1 and the early centriole marker SAS‐6. Deuterosome numbers are decreased and deuterosome size enlarged in Ccno‐deficient MCCs as quantified in (C). Deuterosome‐dependent centriole biogenesis is severely reduced in Ccno‐deficient MCCs as shown by reduced staining for the early centriole marker SAS‐6."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "IFstaining for DEUP1 reveals a further size increase of deuterosomes of Ccno‐deficient MCCs at later stages of centriole biogenesis (ALI day 7). Deuterosome number and size were quantified in (C). IF using a Centrin antibody shows globally reduced presence of centrioles at ALI day 7, which stay localized below the level of deuterosomes and fail to dock to the apical cellmembrane in Ccno‐deficient MCCs as seen in z‐projection."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "IFstaining for DEUP1 in (A, B) was analysed by Imaris 7.7.2 software to calculate average deuterosome number of wild‐type (n = 17) and Ccno‐deficient (n = 19) MCCs at ALI day 3, and wild‐type (n = 12) and Ccno‐deficient (n = 14) MCCs at ALI day 7. Deuterosome size was measured using the spot measurement tool in n = 10 MCCs for both genotypes at ALI day 3, and in wild‐type (n = 12) and Ccno‐deficient (n = 14) MCCs at ALI day 7."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "A, B IF analysis of mTEC cultures at ALI day 7 using antibodies against the centriole marker Centrin and CEP164, which marks maturing centrioles. At ALI day 7, centrioles of wild‐type MCCs are decorated with CEP164 and are mostly localized to the apical cellmembrane. The fewer centrioles of Ccno‐deficient MCCs do not colocalize with CEP164 and fail to reach the apical cell surface as seen in z‐projection. Lack of CEP164 indicates immature centrioles in Ccno‐deficient MCCs. (B) Total centriole numbers per MCC were counted in n = 11 MCCs for both genotypes using Imaris 7.7.2 software."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "C, D Double IFstaining using Centrin‐ and CP110‐specific antibodies shows an almost complete absence of CP110 from Centrin‐positive centrioles in the majority of wild‐type MCCs at day 7 of ALI cultures. Most Ccno‐deficient MCCs exhibit pronounced CP110 staining that colocalizes with Centrin as seen in z‐projection. (D) CP110‐positive MCCs were counted in wild‐type and Ccno‐deficient MTEC cultures and the percentages of CP110‐positive MCCs from total MCCs calculated."
NCBI gene IDs:
"Ccno: 218630"
Figure legend: "(A) BMDMs were infected with L. pneumophila JR32 or the legA9 mutant with MOI of 0.5. CFUs were scored at 1, 24, 48, and 72 h. (B) BMDMs were infected with JR32 or the legA9 mutant harboring empty PL, or legA9+ legA9 pBC‐KS+ PL. (A, B) Data are presented as means ± SD of at least three independent experiments. Asterisks indicate significant differences, (*p &lt; 0.05, **p &lt; 0.01, ***p &lt; 0.001; two‐tailed t‐test)."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "Four female C57BL/6 mice/group received 1 × 106 of JR32 or legA9 mutant bacteria intratracheally. Lungs were homogenized and plated for CFUs counting at (C) 4 or (D) 48 h postinfection. (C, D) Data are shown as mean + SD of n = 4 and are representative as one of two independent experiments. Asterisks indicate significant differences (**p &lt; 0.01 two‐tailed t‐test)"
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "(A) Representative images from 6 h infected WT BMDMs with JR32 or legA9 mutant bacteria. Nuclei were stained blue with DAPI and L. pneumophila stained green with L. pneumophila antibody. Lyso−tracker red was used to stain acidified lysosomes. White arrows show L. pneumophila colocalization with lysotracker."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "(C) Representative images from 6 h infected WT BMDMs with JR32 or legA9 mutant bacteria. LC3 is stained red with LC3 antibody. White arrows show L. pneumophila colocalization with LC3."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "Induction of autophagy in macrophages restricts legA9 mutant replication, and rescues colocalization with LC3 and fusion with lysosomes. BMDMs were untreated or pretreated with rapamycin (Rap) for 1 h and kept throughout the infection. BMDMs were infected with L. pneumophila JR32 or the leg A9 mutant for (A) 1 or (B) 24 h with an MOI of 0.5. CFUs were scored at these time points."
NCBI gene IDs:
"JR32: 
leg A9: 19831968
legA9: 19831968"
Figure legend: "(A) BMDMs derived from WT and Atg5−/− mice were infected with L. pneumophila JR32 or legA9 mutant at an MOI of 0.5. Data are shown as mean ± SD of n = 3 and are representative of two independent experiments. Asterisks indicate significant differences (*p &lt; 0.05; two−tailed t−test."
NCBI gene IDs:
"JR32: 
Atg5: 11793
legA9: 19831968"
Figure legend: "(B) Western blot showing the absence of Atg 5 in the knockout. Data are representative of three independent experiments."
NCBI gene IDs:
"Atg 5: 11793"
Figure legend: "(A) Representative images from 6 h infected BMDMs with JR32 or legA9 mutant bacteria. Polyubiquitin is stained red. White arrows show L. pneumophila colocalization with polyubiquitin."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "(A) Representative images from 6 h infected BMDMs with JR32 or legA9 mutant bacteria. P62 is stained red with p62 antibody. White arrows show L. pneumophila colocalization with p62."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "(C)BMDMs were infected with JR32 or the legA9 mutant for 6 h and the level of p62 protein was quantified in cell lysates by ELISA (performed in triplicate and the SD are too small to detect)."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "BMDMs were nucleofected with scrambled control (sictrl) or siRNA against p62 (sip 62). Twenty‐four hours after nucleofection, murine macrophages were infected with JR32 or legA9 mutant with an MOI of 0.5 for 1 h (D and F) or 24 h (E and G)."
NCBI gene IDs:
"JR32: 
legA9: 19831968
p62: 18412"
Figure legend: "(H) Western blot analysis showing the downregulation of p62 at 24 and 48 h postnucleofection. (A-B and D-H) Data are shown as mean + SD of n = 3 and are representative of three independent experiments. (C) Data are representative of one experiment n = 3. Asterisks indicate significant differences (*p &lt; 0.05, **p &lt; 0.01; two−tailed t−test)."
NCBI gene IDs:
"p62: 18412"
Figure legend: "(A) Caspase−1 KO (casp−1−/−) macrophages were infected with L. pneumophila JR32 or legA9 with an MOI of 0.5 for 1, 24, 48, and 72 h."
NCBI gene IDs:
"JR32: 
Caspase−1: 12362
legA9: 19831968"
Figure legend: "(B) CFUs were measured at the indicated time points. Levels of IL‐1β were detected in supernatants of WT or casp‐1−/− BMDMs infected with JR32 or the legA9 mutant after 24 h. WT BMDMs were either not treated (NT) or infected with L. pneumophila JR32 or legA9 mutant bacteria for 2 h."
NCBI gene IDs:
"JR32: 
casp‐1: 12362
legA9: 19831968"
Figure legend: "(A) BMDMs were not infected (NT) or infected with L. pneumophila JR32 or the legA9 mutant at an MOI of 0.5, 1 or 5 for 24 h. Apoptosis was quantified by Photometric enzyme immunoassay analysis of cytoplasmic (apoptosis) histone−associated−DNA fragments (ELISA)."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "(B) BMDMs were either not treated (NT) or treated with L. pneumophila JR32 or the legA9 mutant at an MOI of 0.5 or 5 for 24 h. The fold change in LDH release was measured from the overall population of macrophages. (A-B) Data are shown as mean ± SD of n = 3 and are representative of three independent experiments."
NCBI gene IDs:
"JR32: 
legA9: 19831968"
Figure legend: "J Comparison of Overall survival (OS) rates for the high-correlation and low-correlation groups, stratified using the EP0_MUC5B (left panel) and EP2_POSTN (right panel) signatures in TCGA. P values are calculated using the log-rank test (N=255)."
NCBI gene IDs:
"MUC5B: 727897
POSTN: 10631"
Figure legend: "G Comparison of Overall survival (OS) rates for the high-correlation and low-correlation groups, stratified using the Macro_C1QC (upper panel), and Mast_CPA3 (lower panel) signatures in TCGA (N=255). P values are calculated using the log-rank test."
NCBI gene IDs:
"C1QC: 714
CPA3: 1359"
Figure legend: "Sections of K14CreER:H2B-mCherry mice at P4. Scale bar: 100 μm. (Bottom) Quantification of mCherry-positive cells (n=3).. The data from individual mice are connected by lines. Student's t-test. NS, no significance. Whole-mount imaging of K14CreER:R26R-confetti samples at P4. Scale bar: 200 μm. Sections of Lrig1CreER:H2B-mCherry mouse skin at P4. Scale bar: 100 μm. (Bottom) Quantification of mCherry-positive cells (n=3). The data from individual mice are connected by lines. *0.01 test. Whole-mount imaging of Lrig1CreER:R26R-confetti mouse samples at P4. Scale bar: 200 μm. "
NCBI gene IDs:
"mCherry: 
Cre: 2777477
ER: 13982
H2B: 319177
K14: 16664
Lrig1: 16206"
Figure legend: "H&amp;E (P2, left), ITGA6 (P2, middle) and LOR staining (P4, right) of Col17a1-/- mice (top) and littermate controls (bottom) . The regenerated epidermis is indicated by arrowheads. Scale bar: 200 μm."
NCBI gene IDs:
"Col17a1: 12821"
Figure legend: "BrdU labeling of Col17a1-/- skin at P2. Scale bar: 100 μm. (Bottom) Quantification of BrdU-positive cells in the epidermis surrounding blisters (n= 3 (control) and 4 (Col17a1-/-) biological replicates). The data are shown as the mean ± SE. Student's t-test. NS, no significance."
NCBI gene IDs:
"Col17a1: 12821"
Figure legend: "Lineage tracing of K14CreER:R26R-mCherry:Col17a1-/- at P4. Scale bar: 100 μm."
NCBI gene IDs:
"mCherry: 
Col17a1: 12821
Cre: 2777477
ER: 13982
K14: 16664"