Original: In all, there are over 1,000 rooms with the most famous including Raphael's Rooms and the Sistine Chapel with its renowned ceiling frescoes painted by Michelangelo (restored between 1980 and 1990).
Simplified: In all there are over 1,000 rooms with the most famous including the Sistine Chapel and its renowned ceiling frescoes painted by Michelangelo (restored between 1980-1990) and Raphael's Rooms.