Original: Set in Pasadena, California, the show concerns two male Caltech prodigies in their twenties, one an experimental physicist (Leonard) and the other a theoretical physicist (Sheldon), who live across the hall from an attractive blonde waitress with show-biz aspirations (Penny).
Simplified: It concerns two male Caltech prodigies in their twenties, one an experimental physicist (Leonard) and the other a theoretical physicist (Sheldon), who live across the hall from an attractive blonde waitress with show-biz aspirations (Penny).