Claim: The NFKB complex is assisted by I-kappa-B proteins, phosphorylation (biochemical process that involves the addition of phosphate to an organic compound) of the serine residues of which by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex.
Evidence: NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. When phosphorylated on these serines (e.g., serines 32 and 36 in human IκBα), the IκB proteins are modified by a process called ubiquitination, which then leads them to be degraded by a cell structure called the proteasome.