Claim: GABRG2's GABA (Gamma-aminobutyric acid) receptors are pentameric chloride channels in which its mutations have been linked to epilepsy.
Evidence: Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. Mutations in this gene have been associated with epilepsy and febrile seizures.