Claim: The zinc fingers of KLF6 protein are responsible for the specific DNA binding and this specific protein, which differ from one another primarily in their sequence of amino acids,  may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes.
Evidence: The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.