Claim: PMS2,  a gene that encodes for DNA repair proteins involved in mismatch repair, has been shown to interact with MLH1,  a gene commonly associated with hereditary nonpolyposis colorectal cancer.
Evidence: Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene. Exons 1 through 5 of these homologues share high degree of identity to human PMS2 The product of this gene is involved in DNA mismatch repair. PMS2 has been shown to interact with MLH1 by forming the heterodimer MutLα. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer.