Claim: The zinc fingers of KLF6 protein are responsible for the specific DNA binding and this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes.
Evidence: Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.