Claim: CD163 shed for some reasons that are yet determined, and it was proven that there is no way that this protein has any connections with infectious diseases.
Evidence: sCD163 shedding occurs as a result of enzymatic cleavage by ADAM17. 
sCD163 shedding occurs in humans but not mice, due to the emergence of an Arg-Ser-Ser-Arg sequence in humans, essential for enzymatic cleavage by ADAM17.