Druvith/medqa1 huggingface dataset:
Question:  What are the stages of Childhood Central Nervous System Germ Cell Tumors ?
Answer: Key Points
								                    - Childhood central nervous system (CNS) germ cell tumors rarely spread outside of the brain and spinal cord.
								                
								                
								                    Childhood central nervous system (CNS) germ cell tumors rarely spread outside of the brain and spinal cord.
								                    Staging is the process used to find out how much cancer there is and if cancer has spread. There is no standard staging system for childhood central nervous system (CNS) germ cell tumors. The treatment plan depends on the following:         - The type of germ cell tumor.    - Whether the tumor has spread within the CNS or to other parts of the body.    - The results of tests and procedures done to diagnose childhood CNS germ cell tumors.     - Whether the tumor is newly diagnosed or has recurred (come back) after treatment.
Question:  What causes Childhood Central Nervous System Germ Cell Tumors ?
Answer: The cause of most childhood CNS germ cell tumors is not known.
Question:  What are the symptoms of Childhood Central Nervous System Germ Cell Tumors ?
Answer: Signs and symptoms of childhood CNS germ cell tumors include unusual thirst, frequent urination, early puberty, or vision changes. Signs and symptoms depend on the following:         - Where the tumor has formed.    - The size of the tumor.    - Whether the tumor makes hormones.        Signs and symptoms may be caused by childhood CNS germ cell tumors or by other conditions. Check with your childs doctor if your child has any of the following:         - Being very thirsty.    - Making large amounts of urine that is clear or almost clear.    - Frequent urination.    - Bed wetting or getting up at night to urinate.    - Trouble moving the eyes or trouble seeing clearly.    - Loss of appetite.    - Weight loss for no known reason.    - Early or late puberty.    - Short stature (being shorter than normal).    - Headaches.    -  Nausea and vomiting.    - Feeling very tired.    - Having problems with school work.
Question:  What is the outlook for Childhood Central Nervous System Germ Cell Tumors ?
Answer: Certain factors affect prognosis (chance of recovery). The prognosis (chance of recovery) depends on the following:          - The type of germ cell tumor.    - The type and level of any tumor markers.    - Where the tumor is in the brain or in the spinal cord.    -  Whether the cancer has spread within the brain and spinal cord or to other parts of the body.     - Whether the tumor is newly diagnosed or has recurred (come back) after treatment.
Question:  what research (or clinical trials) is being done for Childhood Central Nervous System Germ Cell Tumors ?
Answer: Check the list of NCI-supported cancer clinical trials that are now accepting patients with childhood central nervous system germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI website.
            					
                    New types of treatment are being tested in clinical trials.
                    Information about clinical trials is available from the NCI website.
                
                
                    Patients may want to think about taking part in a clinical trial.
                    For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.   Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.   Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
                
                
                    Patients can enter clinical trials before, during, or after starting their cancer treatment.
                    Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.    Clinical trials are taking place in many parts of the country. See the Current Clinical Trials section that follows for links to current treatment clinical trials. These have been retrieved from the NCI's listing of clinical trials.
Question:  What is (are) Childhood Acute Lymphoblastic Leukemia ?
Answer: Key Points
                    - Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many immature lymphocytes (a type of white blood cell).    - Leukemia may affect red blood cells, white blood cells, and platelets.    - Past treatment for cancer and certain genetic conditions affect the risk of having childhood ALL.    - Signs of childhood ALL include fever and bruising.    - Tests that examine the blood and bone marrow are used to detect (find) and diagnose childhood ALL.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                 
                
                    Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many immature lymphocytes (a type of white blood cell).
                    Childhood acute lymphoblastic leukemia (also called ALL or acute lymphocytic leukemia) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated.     ALL is the most common type of cancer in children.
                
                
                    Leukemia may affect red blood cells, white blood cells, and platelets.
                    In a healthy child, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.   A myeloid stem cell becomes one of three types of mature blood cells:         -  Red blood cells that carry oxygen and other substances to all tissues of the body.    -  Platelets that form blood clots to stop bleeding.    -  White blood cells that fight infection and disease.         A lymphoid stem cell becomes a lymphoblast cell and then one of three types of lymphocytes (white blood cells):         -  B lymphocytes that make antibodies to help fight infection.    -  T lymphocytes that help B lymphocytes make the antibodies that help fight infection.    -  Natural killer cells that attack cancer cells and viruses.         In a child with ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. The cells do not work like normal lymphocytes and are not able to fight infection very well. These cells are cancer (leukemia) cells. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may lead to infection, anemia, and easy bleeding.   This summary is about acute lymphoblastic leukemia in children, adolescents, and young adults. See the following PDQ summaries for information about other types of leukemia:         -  Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment     -  Adult Acute Lymphoblastic Leukemia Treatment     -  Chronic Lymphocytic Leukemia Treatment     -  Adult Acute Myeloid Leukemia Treatment     -  Chronic Myelogenous Leukemia Treatment     -  Hairy Cell Leukemia Treatment
Question:  What are the symptoms of Childhood Acute Lymphoblastic Leukemia ?
Answer: Signs of childhood ALL include fever and bruising. These and other signs and symptoms may be caused by childhood ALL or by other conditions. Check with your child's doctor if your child has any of the following:         -  Fever.    - Easy bruising or bleeding.    -  Petechiae (flat, pinpoint, dark-red spots under the skin caused by bleeding).    - Bone or joint pain.    - Painless lumps in the neck, underarm, stomach, or groin.    - Pain or feeling of fullness below the ribs.    - Weakness, feeling tired, or looking pale.    - Loss of appetite.
Question:  What is the outlook for Childhood Acute Lymphoblastic Leukemia ?
Answer: Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on:         - How quickly and how low the leukemia cell count drops after the first month of treatment.    - Age at the time of diagnosis, gender, race, and ethnic background.    - The number of white blood cells in the blood at the time of diagnosis.    - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether there are certain changes in the chromosomes or genes of the lymphocytes with cancer.    - Whether the child has Down syndrome.    - Whether leukemia cells are found in the cerebrospinal fluid.    - The child's weight at the time of diagnosis and during treatment.        Treatment options depend on:         - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether the child has standard-risk, high-risk, or very highrisk ALL.    - The age of the child at the time of diagnosis.    - Whether there are certain changes in the chromosomes of lymphocytes, such as the Philadelphia chromosome.    - Whether the child was treated with steroids before the start of induction therapy.    - How quickly and how low the leukemia cell count drops during treatment.        For leukemia that relapses (comes back) after treatment, the prognosis and treatment options depend partly on the following:         - How long it is between the time of diagnosis and when the leukemia comes back.    - Whether the leukemia comes back in the bone marrow or in other parts of the body.
Question:  what research (or clinical trials) is being done for Childhood Acute Lymphoblastic Leukemia ?
Answer: New types of treatment are being tested in clinical trials.
                    This summary section describes treatments that are being studied in clinical trials. It may not mention every new treatment being studied. Information about clinical trials is available from the NCI website.     Chimeric antigen receptor (CAR) T-cell therapy     CAR T-cell therapy is a type of immunotherapy that changes the patient's T cells (a type of immune system cell) so they will attack certain proteins on the surface of cancer cells. T cells are taken from the patient and special receptors are added to their surface in the laboratory. The changed cells are called chimeric antigen receptor (CAR) T cells. The CAR T cells are grown in the laboratory and given to the patient by infusion. The CAR T cells multiply in the patient's blood and attack cancer cells. CAR T-cell therapy is being studied in the treatment of childhood ALL that has relapsed (come back) a second time.
                
                
                    Patients may want to think about taking part in a clinical trial.
                    For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.   Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.   Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
                
                
                    Patients can enter clinical trials before, during, or after starting their cancer treatment.
                    Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.   Clinical trials are taking place in many parts of the country. See the Treatment Options section that follows for links to current treatment clinical trials. These have been retrieved from NCI's listing of clinical trials.
Question:  Who is at risk for Childhood Acute Lymphoblastic Leukemia? ?
Answer: Key Points
                    Past treatment for cancer and certain genetic conditions affect the risk of having childhood ALL. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk with your child's doctor if you think your child may be at risk.    Possible risk factors for ALL include the following:         - Being exposed to x-rays before birth.    - Being exposed to radiation.    - Past treatment with chemotherapy.    - Having certain genetic conditions, such as:               -  Down syndrome.      -  Neurofibromatosis type 1.      -  Bloom syndrome.      -  Fanconi anemia.      -  Ataxia-telangiectasia.      -  Li-Fraumeni syndrome.      - Constitutional mismatch repair deficiency (mutations in certain genes that stop DNA from repairing itself, which leads to the growth of cancers at an early age).             - Having certain changes in the chromosomes or genes.
                       
                
                    Risk Groups
                    - In childhood ALL, risk groups are used to plan treatment.    - Relapsed childhood ALL is cancer that has come back after it has been treated.
                
                
                
                    In childhood ALL, risk groups are used to plan treatment.
                    There are three risk groups in childhood ALL. They are described as:         - Standard (low) risk: Includes children aged 1 to younger than 10 years who have a white blood cell count of less than 50,000/L at the time of diagnosis.    - High risk: Includes children 10 years and older and/or children who have a white blood cell count of 50,000/L or more at the time of diagnosis.    - Very high risk: Includes children younger than age 1, children with certain changes in the genes, children who have a slow response to initial treatment, and children who have signs of leukemia after the first 4 weeks of treatment.        Other factors that affect the risk group include the following:         - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether there are certain changes in the chromosomes or genes of the lymphocytes.    - How quickly and how low the leukemia cell count drops after initial treatment.    - Whether leukemia cells are found in the cerebrospinal fluid at the time of diagnosis.        It is important to know the risk group in order to plan treatment. Children with high-risk or very highrisk ALL usually receive more anticancer drugs and/or higher doses of anticancer drugs than children with standard-risk ALL.
                
                
                
                    Relapsed childhood ALL is cancer that has come back after it has been treated.
                    The leukemia may come back in the blood and bone marrow, brain, spinal cord, testicles, or other parts of the body.    Refractory childhood ALL is cancer that does not respond to treatment.
Question:  What is (are) Colon Cancer ?
Answer: Key Points
                    - Colon cancer is a disease in which malignant (cancer) cells form in the tissues of the colon.    - Health history affects the risk of developing colon cancer.    - Signs of colon cancer include blood in the stool or a change in bowel habits.    - Tests that examine the colon and rectum are used to detect (find) and diagnose colon cancer.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Colon cancer is a disease in which malignant (cancer) cells form in the tissues of the colon.
                    The colon is part of the bodys digestive system. The digestive system removes and processes nutrients (vitamins, minerals, carbohydrates, fats, proteins, and water) from foods and helps pass waste material out of the body. The digestive system is made up of the esophagus, stomach, and the small and large intestines. The colon (large bowel) is the first part of the large intestine and is about 5 feet long. Together, the rectum and anal canal make up the last part of the large intestine and are about 6-8 inches long. The anal canal ends at the anus (the opening of the large intestine to the outside of the body).      Gastrointestinal stromal tumors can occur in the colon. See the PDQ summary on Gastrointestinal Stromal Tumors Treatment for more information.    See the PDQ summary about Unusual Cancers of Childhood Treatment for information about colorectal cancer in children.
Question:  Who is at risk for Colon Cancer? ?
Answer: Health history affects the risk of developing colon cancer. Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk to your doctor if you think you may be at risk for colorectal cancer.    Risk factors for colorectal cancer include the following:            - Having a family history of colon or rectal cancer in a first-degree relative (parent, sibling, or child).     - Having a personal history of cancer of the colon, rectum, or ovary.     - Having a personal history of high-risk adenomas (colorectal polyps that are 1 centimeter or larger in size or that have cells that look abnormal under a microscope).     - Having inherited changes in certain genes that increase the risk of familial adenomatous polyposis (FAP) or Lynch syndrome (hereditary nonpolyposis colorectal cancer).     - Having a personal history of chronic ulcerative colitis or Crohn disease for 8 years or more.     - Having three or more alcoholic drinks per day.     - Smoking cigarettes.     - Being black.     - Being obese.           Older age is a main risk factor for most cancers. The chance of getting cancer increases as you get older.
Question:  What are the symptoms of Colon Cancer ?
Answer: Signs of colon cancer include blood in the stool or a change in bowel habits. These and other signs and symptoms may be caused by colon cancer or by other conditions. Check with your doctor if you have any of the following:         - A change in bowel habits.    -  Blood (either bright red or very dark) in the stool.    -  Diarrhea, constipation, or feeling that the bowel does not empty all the way.    - Stools that are narrower than usual.    - Frequent gas pains, bloating, fullness, or cramps.    - Weight loss for no known reason.    - Feeling very tired.    -  Vomiting.
Question:  How to diagnose Colon Cancer ?
Answer: Tests that examine the colon and rectum are used to detect (find) and diagnose colon cancer. The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patients health habits and past illnesses and treatments will also be taken.    -   Digital rectal exam : An exam of the rectum. The doctor or nurse inserts a lubricated, gloved finger into the rectum to feel for lumps or anything else that seems unusual.    -   Fecal occult blood test (FOBT): A test to check stool (solid waste) for blood that can only be seen with a microscope. A small sample of stool is placed on a special card or in a special container and returned to the doctor or laboratory for testing. Blood in the stool may be a sign of polyps, cancer, or other conditions. There are two types of FOBTs:               -  Guaiac FOBT : The sample of stool on the special card is tested with a chemical. If there is blood in the stool, the special card changes color.      -  Immunochemical FOBT : A liquid is added to the stool sample. This mixture is injected into a machine that contains antibodies that can detect blood in the stool. If there is blood in the stool, a line appears in a window in the machine. This test is also called fecal immunochemical test or FIT.             -   Barium enema : A series of x-rays of the lower gastrointestinal tract. A liquid that contains barium (a silver-white metallic compound) is put into the rectum. The barium coats the lower gastrointestinal tract and x-rays are taken. This procedure is also called a lower GI series.    -   Sigmoidoscopy : A procedure to look inside the rectum and sigmoid (lower) colon for polyps (small areas of bulging tissue), other abnormal areas, or cancer. A sigmoidoscope is inserted through the rectum into the sigmoid colon. A sigmoidoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove polyps or tissue samples, which are checked under a microscope for signs of cancer.    -   Colonoscopy : A procedure to look inside the rectum and colon for polyps, abnormal areas, or cancer. A colonoscope is inserted through the rectum into the colon. A colonoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove polyps or tissue samples, which are checked under a microscope for signs of cancer.    -   Virtual colonoscopy : A procedure that uses a series of x-rays called computed tomography to make a series of pictures of the colon. A computer puts the pictures together to create detailed images that may show polyps and anything else that seems unusual on the inside surface of the colon. This test is also called colonography or CT colonography.     -   Biopsy : The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer.
Question:  What is the outlook for Colon Cancer ?
Answer: Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) and treatment options depend on the following:         - The stage of the cancer (whether the cancer is in the inner lining of the colon only or has spread through the colon wall, or has spread to lymph nodes or other places in the body).    - Whether the cancer has blocked or made a hole in the colon.    - Whether there are any cancer cells left after surgery.    - Whether the cancer has recurred.     - The patients general health.        The prognosis also depends on the blood levels of carcinoembryonic antigen (CEA) before treatment begins. CEA is a substance in the blood that may be increased when cancer is present.