Druvith/medqa huggingface dataset:
What is (are) Adult Acute Lymphoblastic Leukemia ? 

Key Points
                    - Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).    - Leukemia may affect red blood cells, white blood cells, and platelets.    - Previous chemotherapy and exposure to radiation may increase the risk of developing ALL.    - Signs and symptoms of adult ALL include fever, feeling tired, and easy bruising or bleeding.     - Tests that examine the blood and bone marrow are used to detect (find) and diagnose adult ALL.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
                    Adult acute lymphoblastic leukemia (ALL; also called acute lymphocytic leukemia) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated.
                
                
                    Leukemia may affect red blood cells, white blood cells, and platelets.
                    Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.   A myeloid stem cell becomes one of three types of mature blood cells:          -  Red blood cells that carry oxygen and other substances to all tissues of the body.    -  Platelets that form blood clots to stop bleeding.    -  Granulocytes (white blood cells) that fight infection and disease.         A lymphoid stem cell becomes a lymphoblast cell and then one of three types of lymphocytes (white blood cells):         -  B lymphocytes that make antibodies to help fight infection.    -  T lymphocytes that help B lymphocytes make the antibodies that help fight infection.    -  Natural killer cells that attack cancer cells and viruses.         In ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. These cells are also called leukemia cells. These leukemia cells are not able to fight infection very well. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may cause infection, anemia, and easy bleeding. The cancer can also spread to the central nervous system (brain and spinal cord).     This summary is about adult acute lymphoblastic leukemia. See the following PDQ summaries for information about other types of leukemia:          -  Childhood Acute Lymphoblastic Leukemia Treatment.    -  Adult Acute Myeloid Leukemia Treatment.    -  Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment.    -  Chronic Lymphocytic Leukemia Treatment.    -  Chronic Myelogenous Leukemia Treatment.    -  Hairy Cell Leukemia Treatment.
What are the symptoms of Adult Acute Lymphoblastic Leukemia ? 

Signs and symptoms of adult ALL include fever, feeling tired, and easy bruising or bleeding. The early signs and symptoms of ALL may be like the flu or other common diseases. Check with your doctor if you have any of the following:         - Weakness or feeling tired.    -  Fever or night sweats.    - Easy bruising or bleeding.    -  Petechiae (flat, pinpoint spots under the skin, caused by bleeding).    - Shortness of breath.    - Weight loss or loss of appetite.    - Pain in the bones or stomach.    - Pain or feeling of fullness below the ribs.    - Painless lumps in the neck, underarm, stomach, or groin.    - Having many infections.        These and other signs and symptoms may be caused by adult acute lymphoblastic leukemia or by other conditions.
How to diagnose Adult Acute Lymphoblastic Leukemia ? 

Tests that examine the blood and bone marrow are used to detect (find) and diagnose adult ALL. The following tests and procedures may be used:          -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as infection or anything else that seems unusual. A history of the patient's health habits and past illnesses and treatments will also be taken.    -   Complete blood count (CBC) with differential : A procedure in which a sample of blood is drawn and checked for the following:                -  The number of red blood cells and platelets.      - The number and type of white blood cells.      - The amount of hemoglobin (the protein that carries oxygen) in the red blood cells.      - The portion of the blood sample made up of red blood cells.              -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.    -   Peripheral blood smear : A procedure in which a sample of blood is checked for blast cells, the number and kinds of white blood cells, the number of platelets, and changes in the shape of blood cells.    -   Bone marrow aspiration and biopsy : The removal of bone marrow, blood, and a small piece of bone by inserting a hollow needle into the hipbone or breastbone. A pathologist views the bone marrow, blood, and bone under a microscope to look for abnormal cells. The following tests may be done on the samples of blood or bone marrow tissue that are removed:               -  Cytogenetic analysis:  A laboratory test in which the cells in a sample of blood or bone marrow are looked at under a microscope to find out if there are certain changes in the chromosomes of lymphocytes. For example, in Philadelphia chromosome positive ALL, part of one chromosome switches places with part of another chromosome. This is called the Philadelphia chromosome.       -  Immunophenotyping : A process used to identify cells, based on the types of antigens or markers on the surface of the cell. This process is used to diagnose the subtype of ALL by comparing the cancer cells to normal cells of the immune system. For example, a cytochemistry study may test the cells in a sample of tissue using chemicals (dyes) to look for certain changes in the sample. A chemical may cause a color change in one type of leukemia cell but not in another type of leukemia cell.
What is the outlook for Adult Acute Lymphoblastic Leukemia ? 

Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) and treatment options depend on the following:         - The age of the patient.    - Whether the cancer has spread to the brain or spinal cord.    - Whether there are certain changes in the genes, including the Philadelphia chromosome.    - Whether the cancer has been treated before or has recurred (come back).
Who is at risk for Adult Acute Lymphoblastic Leukemia? ? 

Previous chemotherapy and exposure to radiation may increase the risk of developing ALL. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Possible risk factors for ALL include the following:         - Being male.    - Being white.    - Being older than 70.    - Past treatment with chemotherapy or radiation therapy.    - Being exposed to high levels of radiation in the environment (such as nuclear radiation).    - Having certain genetic disorders, such as Down syndrome.
What are the stages of Adult Acute Lymphoblastic Leukemia ? 

Key Points
                    - Once adult ALL has been diagnosed, tests are done to find out if the cancer has spread to the central nervous system (brain and spinal cord) or to other parts of the body.    - There is no standard staging system for adult ALL.
                
                
                    Once adult ALL has been diagnosed, tests are done to find out if the cancer has spread to the central nervous system (brain and spinal cord) or to other parts of the body.
                    The extent or spread of cancer is usually described as stages. It is important to know whether the leukemia has spread outside the blood and bone marrow in order to plan treatment. The following tests and procedures may be used to determine if the leukemia has spread:          -   Chest x-ray : An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.    -   Lumbar puncture : A procedure used to collect a sample of cerebrospinal fluid (CSF) from the spinal column. This is done by placing a needle between two bones in the spine and into the CSF around the spinal cord and removing a sample of the fluid. The sample of CSF is checked under a microscope for signs that leukemia cells have spread to the brain and spinal cord. This procedure is also called an LP or spinal tap.    -   CT scan (CAT scan): A procedure that makes a series of detailed pictures of the abdomen, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.    -   MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
                
                
                    There is no standard staging system for adult ALL.
                    The disease is described as untreated, in remission, or recurrent.    Untreated adult ALL    The ALL is newly diagnosed and has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain.          - The complete blood count is abnormal.    - More than 5% of the cells in the bone marrow are blasts (leukemia cells).    - There are signs and symptoms of leukemia.         Adult ALL in remission    The ALL has been treated.         - The complete blood count is normal.    - 5% or fewer of the cells in the bone marrow are blasts (leukemia cells).    - There are no signs or symptoms of leukemia other than in the bone marrow.
What is (are) Oral Cavity and Oropharyngeal Cancer ? 

Key Points
                    - Oral cavity and oropharyngeal cancer are diseases in which malignant (cancer) cells form in the mouth and throat.    - The number of new cases of oral cavity and oropharyngeal cancer and the number of deaths from oral cavity and oropharyngeal cancer varies by race and gender.    - Different factors increase or decrease the risk of oral cavity and oropharyngeal cancer.
                
                
                    Oral cavity and oropharyngeal cancer are diseases in which malignant (cancer) cells form in the mouth and throat.
                    Oral cavity cancer forms in any of these tissues of the oral cavity:         - The front two thirds of the tongue.    - The gingiva (gums).    - The buccal mucosa (the lining of the inside of the cheeks).    - The floor (bottom) of the mouth under the tongue.    - The hard palate (the front of the roof of the mouth).    - The retromolar trigone (the small area behind the wisdom teeth).          Oropharyngeal cancer forms in any of these tissues of the oropharynx:         - The middle part of the pharynx (throat) behind the mouth.    - The back one third of the tongue.    - The soft palate (the back of the roof of the mouth).    - The side and back walls of the throat.    - The tonsils.          Most oral cavity and oropharyngeal cancers start in squamous cells, the thin, flat cells that line the lips, oral cavity, and oropharynx. Cancer that forms in squamous cells is called squamous cell carcinoma.   See the following PDQ summaries for more information about the screening, diagnosis, and treatment of oral cavity and oropharyngeal cancer:         -  Oral Cavity and Oropharyngeal Cancer Prevention     -  Lip and Oral Cavity Cancer Treatment     -  Oropharyngeal Cancer Treatment
                
                
                    The number of new cases of oral cavity and oropharyngeal cancer and the number of deaths from oral cavity and oropharyngeal cancer varies by race and gender.
                    Over the past ten years, the number of new cases and deaths from oral cavity and oropharyngeal cancer slightly increased in white men and women. The number slightly decreased among black men and women.   Oral cavity and oropharyngeal cancer is more common in men than in women. Although oral cavity and oropharyngeal cancer may occur in adults of any age, it occurs most often in those aged 55 to 64 years.   France, Brazil, and parts of Asia have much higher rates of oral cavity and oropharyngeal cancer than most other countries.    The number of new cases of oropharyngeal cancer caused by certain types of human papillomavirus (HPV) infection has increased. One kind of HPV, called HPV 16, is often passed from one person to another during sexual activity.
Who is at risk for Oral Cavity and Oropharyngeal Cancer? ? 

The number of new cases of oral cavity and oropharyngeal cancer and the number of deaths from oral cavity and oropharyngeal cancer varies by race and gender. Over the past ten years, the number of new cases and deaths from oral cavity and oropharyngeal cancer slightly increased in white men and women. The number slightly decreased among black men and women.   Oral cavity and oropharyngeal cancer is more common in men than in women. Although oral cavity and oropharyngeal cancer may occur in adults of any age, it occurs most often in those aged 55 to 64 years.   France, Brazil, and parts of Asia have much higher rates of oral cavity and oropharyngeal cancer than most other countries.    The number of new cases of oropharyngeal cancer caused by certain types of human papillomavirus (HPV) infection has increased. One kind of HPV, called HPV 16, is often passed from one person to another during sexual activity.
Who is at risk for Oral Cavity and Oropharyngeal Cancer? ? 

Different factors increase or decrease the risk of oral cavity and oropharyngeal cancer. Anything that increases your chance of getting a disease is called a risk factor. Anything that decreases your chance of getting a disease is called a protective factor.    For information about risk factors and protective factors for oral cavity and oropharyngeal cancer, see the PDQ summary on Oral Cavity and Oropharyngeal Cancer Prevention.
What is (are) Chronic Myelogenous Leukemia ? 

Key Points
                    - Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells.    - Leukemia may affect red blood cells, white blood cells, and platelets.    - Signs and symptoms of chronic myelogenous leukemia include fever, night sweats, and tiredness.     - Most people with CML have a gene mutation (change) called the Philadelphia chromosome.    - Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myelogenous leukemia.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells.
                    Chronic myelogenous leukemia (also called CML or chronic granulocytic leukemia) is a slowly progressing blood and bone marrow disease that usually occurs during or after middle age, and rarely occurs in children.
                
                
                    Leukemia may affect red blood cells, white blood cells, and platelets.
                    Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell.    A myeloid stem cell becomes one of three types of mature blood cells:         -  Red blood cells that carry oxygen and other substances to all tissues of the body.    -  Platelets that form blood clots to stop bleeding.    -  Granulocytes (white blood cells) that fight infection and disease.         In CML, too many blood stem cells become a type of white blood cell called granulocytes. These granulocytes are abnormal and do not become healthy white blood cells. They are also called leukemia cells. The leukemia cells can build up in the blood and bone marrow so there is less room for healthy white blood cells, red blood cells, and platelets. When this happens, infection, anemia, or easy bleeding may occur.   This summary is about chronic myelogenous leukemia. See the following PDQ summaries for more information about leukemia:          -  Adult Acute Lymphoblastic Leukemia Treatment     -  Childhood Acute Lymphoblastic Leukemia Treatment     -  Adult Acute Myeloid Leukemia Treatment     -  Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment     -  Chronic Lymphocytic Leukemia Treatment     -  Hairy Cell Leukemia Treatment
What are the symptoms of Chronic Myelogenous Leukemia ? 

Signs and symptoms of chronic myelogenous leukemia include fever, night sweats, and tiredness. These and other signs and symptoms may be caused by CML or by other conditions. Check with your doctor if you have any of the following:         - Feeling very tired.    - Weight loss for no known reason.    - Night sweats.    -  Fever.    - Pain or a feeling of fullness below the ribs on the left side.        Sometimes CML does not cause any symptoms at all.
What are the genetic changes related to Chronic Myelogenous Leukemia ? 

Most people with CML have a gene mutation (change) called the Philadelphia chromosome. Every cell in the body contains DNA (genetic material) that determines how the cell looks and acts. DNA is contained inside chromosomes. In CML, part of the DNA from one chromosome moves to another chromosome. This change is called the  Philadelphia chromosome. It results in the bone marrow making an enzyme, called tyrosine kinase, that causes too many stem cells to become white blood cells (granulocytes or blasts).   The Philadelphia chromosome is not passed from parent to child.
How to diagnose Chronic Myelogenous Leukemia ? 

Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myelogenous leukemia.. The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease such as an enlarged spleen. A history of the patients health habits and past illnesses and treatments will also be taken.    -   Complete blood count (CBC) with differential : A procedure in which a sample of blood is drawn and checked for the following:                -  The number of red blood cells and platelets.      - The number and type of white blood cells.      - The amount of hemoglobin (the protein that carries oxygen) in the red blood cells.      - The portion of the blood sample made up of red blood cells.              -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.     -   Bone marrow aspiration and biopsy : The removal of bone marrow, blood, and a small piece of bone by inserting a needle into the hipbone or breastbone. A pathologist views the bone marrow, blood, and bone under a microscope to look for abnormal cells. One of the following tests may be done on the samples of blood or bone marrow tissue that are removed:                -  Cytogenetic analysis: A test in which cells in a sample of blood or bone marrow are viewed under a microscope to look for certain changes in the chromosomes, such as the Philadelphia chromosome.      -  FISH (fluorescence in situ hybridization): A laboratory technique used to look at genes or chromosomes in cells and tissues. Pieces of DNA that contain a fluorescent dye are made in the laboratory and added to cells or tissues on a glass slide. When these pieces of DNA bind to specific genes or areas of chromosomes on the slide, they light up when viewed under a microscope with a special light.       -  Reverse transcriptionpolymerase chain reaction (RTPCR): A laboratory test in which cells in a sample of tissue are studied using chemicals to look for certain changes in the structure or function of genes.
What is the outlook for Chronic Myelogenous Leukemia ? 

Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) and treatment options depend on the following:         - The patients age.    - The phase of CML.    - The amount of blasts in the blood or bone marrow.    - The size of the spleen at diagnosis.    - The patients general health.
What are the stages of Chronic Myelogenous Leukemia ? 

Key Points
                    - After chronic myelogenous leukemia has been diagnosed, tests are done to find out if the cancer has spread.    - Chronic myelogenous leukemia has 3 phases.         - Chronic phase     - Accelerated phase     - Blastic phase
                
                
                    After chronic myelogenous leukemia has been diagnosed, tests are done to find out if the cancer has spread.
                    Staging is the process used to find out how far the cancer has spread. There is no standard staging system for chronic myelogenous leukemia (CML). Instead, the disease is classified by phase: chronic phase, accelerated phase, or blastic phase. It is important to know the phase in order to plan treatment. The information from tests and procedures done to detect (find) and diagnose chronic myelogenous leukemia is also used to plan treatment.
                
                
                    Chronic myelogenous leukemia has 3 phases.
                    As the amount of blast cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may result in infections, anemia, and easy bleeding, as well as bone pain and pain or a feeling of fullness below the ribs on the left side. The number of blast cells in the blood and bone marrow and the severity of signs or symptoms determine the phase of the disease.     Chronic phase    In chronic phase CML, fewer than 10% of the cells in the blood and bone marrow are blast cells.       Accelerated phase    In accelerated phase CML, 10% to 19% of the cells in the blood and bone marrow are blast cells.       Blastic phase    In blastic phase CML, 20% or more of the cells in the blood or bone marrow are blast cells. When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis.